WO2021068362A1 - 生物体刺激装置及系统 - Google Patents

生物体刺激装置及系统 Download PDF

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Publication number
WO2021068362A1
WO2021068362A1 PCT/CN2019/119863 CN2019119863W WO2021068362A1 WO 2021068362 A1 WO2021068362 A1 WO 2021068362A1 CN 2019119863 W CN2019119863 W CN 2019119863W WO 2021068362 A1 WO2021068362 A1 WO 2021068362A1
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stimulation
biological
component
organism
light
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PCT/CN2019/119863
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English (en)
French (fr)
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贾香连
唐永强
王立平
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中国科学院深圳先进技术研究院
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Publication of WO2021068362A1 publication Critical patent/WO2021068362A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D1/00—Surgical instruments for veterinary use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00—Appliances for supporting or fettering animals for operative purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0044—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the sight sense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2250/00—Specially adapted for animals

Definitions

  • the embodiments of the present invention relate to the field of life science technology, for example, to a biological stimulation device and system.
  • Restraint stress stimulation is a typical physiological and physical stress stimulation method, which is often used as a model in the study of stress stress.
  • the device is first restrained for restraint stress stimulation, and then other devices (for example, light stimulation devices) are used for other stimulation (for example, light stimulation).
  • other devices for example, light stimulation devices
  • the embodiment of the present invention provides a biological stimulation device and system, so as to achieve the effect of providing other stimulations while performing restraint stress stimulation, and accurately acquiring biological characteristic parameters.
  • an embodiment of the present invention provides a biological stimulation device, including:
  • a stimulation component the first end of the stimulation component is implanted into the head of the organism, the second end of the stimulation component is exposed to the air, and the stimulation component is used to cause the organism to produce a first stress response;
  • a restraint member the restraint member includes a first hole, the stimulation member passes through the first hole, and the restraint member is used to restrain the movement of the organism so that the organism generates a second stress response.
  • it also includes:
  • a fixing component the fixing component includes a through hole, the through hole wraps the middle part of the stimulation component, and one end of the fixing component is attached to the surface of the head.
  • the restraint member further includes a second hole, and the second hole is used for exposing the biological body to the air.
  • the stimulation component includes at least one of an optical fiber and a microcatheter, the optical fiber is used to provide light stimulation to the organism, and the microcatheter is used to provide drug stimulation to the organism.
  • the binding member is made of soft material.
  • the binding member has a cylindrical shape.
  • an embodiment of the present invention provides a text information retrieval device, including:
  • a stimulation conduction device configured to conduct stimulation to the second end of the stimulation component
  • the stimulation generating device is configured to provide a source of stimulation and transmit it to the stimulation conducting device.
  • the stimulus transmission device is an optical fiber
  • the stimulus generation device is a light source
  • the light source is configured to provide light stimulation.
  • it also includes:
  • a waveform generator the input end of the waveform generator is connected to the light source, the output end of the waveform generator is connected to the optical fiber, and the waveform generator is configured to adjust the waveform of the light stimulation;
  • the light source transmits the light stimulation to the optical fiber through the waveform generator.
  • the light source is a light emitting diode LED or laser.
  • a stimulation component is used.
  • the first end of the stimulation component is implanted into the head of the organism, the second end of the stimulation component is exposed to the air, and the stimulation component is used to cause the organism to produce the first end.
  • a stress response ; a restraint component, the restraint component includes a first hole, the stimulation component passes through the first hole, the restraint component is used to restrain the movement of the organism, so that the organism produces a second
  • the stress response solves the problem of inaccurate acquisition of biological characteristic parameters due to the time difference between two different stimuli, and realizes that the restraint stress stimulation is provided while other stimuli are provided to accurately obtain biological characteristic parameters. .
  • FIG. 1 is a schematic structural diagram of a biological stimulation device provided by Embodiment 1 of the present invention.
  • FIG. 2 is a schematic structural diagram of a biological stimulation device provided by Embodiment 1 of the present invention.
  • FIG. 3 is a schematic structural diagram of a biological stimulation device provided by Embodiment 1 of the present invention.
  • FIG. 4 is a schematic structural diagram of a biological stimulation system provided by Embodiment 2 of the present invention.
  • Fig. 5 is a schematic structural diagram of a biological stimulation system provided in the second embodiment of the present invention.
  • first”, “second”, etc. may be used herein to describe various directions, actions, steps or elements, etc., but these directions, actions, steps or elements are not limited by these terms. These terms are only used to distinguish a first direction, action, step or element from another direction, action, step or element.
  • the first stress response may be referred to as the second stress response
  • the second stress response may be referred to as the first stress response. Both the first stress response and the second stress response are stress responses, but they are not the same stress response.
  • the terms “first”, “second”, etc. cannot be understood as indicating or implying relative importance or implicitly indicating the number of indicated technical features. Therefore, the features defined with “first” and “second” may explicitly or implicitly include one or more of these features.
  • "a plurality of” means at least two, such as two, three, etc., unless specifically defined otherwise.
  • FIG. 1 is a schematic structural diagram of a biological stimulation device provided in Embodiment 1 of the present invention.
  • an embodiment of the present invention provides a biological stimulation device 10, which includes a stimulation component 100 and a restraint component 200.
  • the biological stimulation device 10 of this embodiment is used to simultaneously perform multiple stimulations on the biological body. among them:
  • the first end 110 of the stimulation component 100 is implanted into the head of the organism, the second end 120 of the stimulation component 100 is exposed to the air, and the stimulation component 100 is used to cause the organism to generate a first stress reaction;
  • the restraint member 200 includes a first hole 210, the stimulation member 100 passes through the first hole 210, and the restraint member 200 is used to restrain the movement of the organism, so that the organism produces a second stress response .
  • the stimulation component 100 may include a light stimulation component, a drug stimulation component, and the like.
  • the light stimulation component is used to provide light stimulation
  • the drug stimulation component is used to provide drug stimulation.
  • the first stress response refers to the stress response generated by the stimulation by the stimulation component 100.
  • Organisms can include mice, monkeys, etc.
  • the organism is a mouse.
  • the restraint member 200 is used to restrain the action of the living body and cause the living body to produce a second stress response, and the second stress response can also be regarded as a restraint stress response.
  • Restraint stress stimulation is a typical physiological and physical stress stimulation method, which is often used as a model in the study of stress stress.
  • the stimulation component 100 includes a first end 110 and a second end 120.
  • the first end 110 of the stimulation part 100 is implanted in the head of the living body, and the second end 120 of the stimulation part 100 is exposed to the air.
  • the stimulus source (for example, light stimulation, drug stimulation) is input through the second end 120 of the stimulating component 100, and the conduction through the stimulating component 100 reaches the first end 110 of the stimulating component 100. Since the first end 110 of the stimulating component 100 is implanted in the biological The head of the human body, the source of stimulation can enter the biological body, such as the brain of a mouse, through the stimulation component 100, and then provide stimulation to the brain.
  • the stimulation component 100 when the stimulation component 100 is a light stimulation component, the stimulation component 100 is an optical fiber; when the stimulation component 100 is a drug stimulation component, the stimulation component 100 is a micro catheter.
  • the optical fiber is used to provide light stimulation to the organism, and the microcatheter is used to provide drug stimulation to the organism.
  • the stimulation component 100 may include only an optical stimulation component or a drug stimulation component, or may include both a drug stimulation component and an optical stimulation component. That is, the stimulation component 100 may include only an optical fiber or a micro-catheter, or may include both an optical fiber and a micro-catheter. catheter.
  • Optical fibers are used to transmit light signals, and microcatheters are used to transmit drugs.
  • the stimulation component 100 is an optical fiber for providing light stimulation. That is, in the study of the restraint stress stimulation mechanism of model animal mice, optogenetics is used to interfere with the neural circuits of mice at the same time.
  • the restraint component 200 includes a first hole 210 through which the stimulation component 100 passes, and the first end 110 of the stimulation component 100 is inside the restraint component 200 and is implanted on the head of the organism.
  • the restraint component 200 needs to be closed.
  • the diameter of the stimulating component 100 is exactly matched with the first hole 210, and the second end of the stimulating component 100 120 is exposed to the air, so that while the restraint stress stimulation is performed, other stimuli can be input through the second end 120 of the stimulation component 100, and does not affect the execution of restraint stress stimulation, realizing the simultaneous execution of restraint stress stimulation and other stimuli. stimulate.
  • the binding member 200 is in the shape of a triangular prism or a cylinder.
  • the restraint member 200 has a cylindrical shape, that is, a restraint cylinder.
  • the binding component 200 is made of soft material.
  • the soft material may include soft plastic or soft cloth.
  • the soft plastic or soft cloth is wound several times to support the binding member 200.
  • FIG. 2 is a schematic structural diagram of a biological stimulation device 10.
  • the restraint member 200 further includes a second hole 220 for exposing the biological body to the air.
  • a biological body part refers to a part of a biological body, through which biological characteristic parameters (for example, blood) can be collected.
  • the organism part is the tail of the organism, such as the tail of a mouse or the tail of a monkey.
  • the size of the second hole 220 is adapted to the size of the biological body.
  • the diameter of the second hole 220 is the same as the diameter of the second hole 220.
  • FIG. 3 is a schematic structural diagram of a biological stimulation device 10.
  • the biological stimulation device 10 further includes a fixing component 300. among them:
  • the fixing member 300 includes a through hole 310 that wraps the middle part of the stimulation member 100, and one end of the fixing member 300 is attached to the surface of the head.
  • one end of the fixing member 300 is a plane or a curved surface that fits the surface of the head of the organism.
  • One end of the fixing member 300 is attached to the surface of the head.
  • the fixing member 300 includes a through hole 310 penetrating through the fixing member 300, the stimulation member 100 passes through the through hole 310, and the first end 110 of the stimulation member 100 is implanted into the head of the organism, and the first end 110 of the stimulation member 100 is implanted into the head of the organism.
  • the two ends 120 are exposed to the air.
  • the through hole 310 wraps the middle part of the stimulation component 100, that is, includes the portion between the first end 110 of the stimulation component 100 and the second end 120 of the stimulation component 100.
  • the size of the through hole 310 is the same as the diameter of the stimulation component 100 or slightly larger than the diameter of the stimulation component 100.
  • the fixing member 300 includes a through hole 310, one end of the fixing member 300 is attached to the surface of the head, and the stimulation member 100 implants the first end 110 into the head of the living body through the through hole 310 Inside, since one end of the fixing member 300 is attached to the surface of the head, the through hole 310 wraps the stimulation member 100, which can prevent the stimulation member 100 from shaking and improve the convenience of operation.
  • the first end of the stimulation component is implanted into the head of the organism through the stimulation component, the second end of the stimulation component is exposed to the air, and the stimulation component is used to make the
  • the organism produces a first stress response;
  • the restraint member the restraint member includes a first hole, the stimulation member passes through the first hole, and the restraint member is used to restrain the movement of the organism so that the organism
  • the body produces a second stress response, which can provide other stimuli while performing restraint stress stimulation, so as to achieve accurate acquisition of biological characteristic parameters.
  • Fig. 4 is a schematic structural diagram of a biological stimulation system provided in the second embodiment of the present invention.
  • an embodiment of the present invention provides a biological stimulation system, which includes a biological stimulation device 10, a stimulation conduction device 20 and a stimulation generation device 30.
  • the biological stimulation system of this embodiment is used to simultaneously perform multiple stimulations on the biological body. among them:
  • the biological stimulation device 10 is used to stimulate the biological body
  • the stimulation conduction device 20 is used to conduct stimulation to the second end of the stimulation component
  • the stimulation generating device 30 is used to provide a source of stimulation and transmit it to the stimulation conducting device 20.
  • the stimulus generating device 30 may be an optical stimulus generating device 30 or a drug stimulating generating device 30.
  • the stimulus transmission device 20 is related to the stimulus generating device 30.
  • the stimulus transmission device 20 is an optical fiber, which is used to conduct the light stimulus from the light source to the second end of the stimulation component in the biological stimulation device 10 to transmit the light stimulus to the head of the biological body. unit.
  • the stimulation generating device 30 is a light stimulation generating device 30, that is, the stimulation generating device 30 is a light source, and the light source is used to provide light stimulation.
  • the stimulation generating device 30 provides a stimulation source and transmits the stimulation source to the stimulation conduction device 20, and the stimulation conduction device 20 conducts the stimulation source to the second end of the stimulation component in the biological stimulation device 10, thereby transferring the stimulation
  • the stimulating component is conducted to the head of the organism, thereby providing restraint stress stimulus while providing other stimuli.
  • the stimulation generating device 30 using a light source, and the stimulation component being an optical fiber as an example, the light source generates light stimulation, which is conducted to the stimulation component (optical fiber) of the biological stimulation device 10 through the stimulation transmission device 20 (optical fiber). The two ends are thus transmitted to the head of the organism.
  • the light source is light with a fixed wavelength.
  • the light source is a light emitting diode LED or laser.
  • the biological stimulation system further includes a waveform generator 40.
  • the input end of the waveform generator 40 is connected to the light source 31, and the output end of the waveform generator 40 is connected to the optical fiber 21 for adjusting the light stimulation waveform; the light source 31 passes through the waveform generator 40 transmits the light stimulus to the optical fiber 21.
  • the waveform generator 40 is used to adjust the waveform of the light stimulation, that is, to adjust the waveform of the light signal.
  • adjusting the waveform of the optical signal includes stabilizing the wavelength of the optical signal, forming a specific wavelength, and controlling the amplitude of the optical signal.
  • the purpose of forming a specific wavelength is to meet the needs of stimulation in different states.
  • the purpose of enhancing the amplitude of the optical signal is to increase the amplitude of the optical signal, so that the stimulation effect is more obvious.
  • a waveform generator 40 is added.
  • the light source 31 transmits the light stimulus to the optical fiber 21 through the waveform generator 40.
  • the wavelength and amplitude of the light stimulus processed by the waveform generator 40 are adjusted to a certain extent.
  • a stable and specific waveform is formed, and the waveform of the light stimulation output to the optical fiber 21 is stable, and then transmitted to the biological stimulation device 10, and the stable light stimulation is transmitted to the head of the biological body through the stimulation component, so that the stimulation The effect is better.
  • the first end of the stimulation component is implanted into the head of the organism through the stimulation component, the second end of the stimulation component is exposed to the air, and the stimulation component is used to make the
  • the organism produces a first stress response;
  • the restraint member the restraint member includes a first hole, the stimulation member passes through the first hole, and the restraint member is used to restrain the movement of the organism so that the organism
  • the body produces a second stress response, which can provide other stimuli while performing restraint stress stimulation, so as to achieve accurate acquisition of biological characteristic parameters.

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Abstract

一种生物体刺激装置（10）及系统，生物体刺激装置（10）包括：刺激部件（100），刺激部件（100）的第一端（110）植入生物体的头部，刺激部件（100）的第二端（120）暴露在空气中，刺激部件（100）用于使生物体产生第一应激反应；束缚部件（200），束缚部件（200）包括第一孔（210），刺激部件（100）穿过第一孔（210），束缚部件（200）用于束缚生物体的行动，以使生物体产生第二应激反应。

Description

生物体刺激装置及系统
本公开要求在2019年10月12日提交中国专利局、申请号为201910969426.0的中国专利申请的优先权，以上申请的全部内容通过引用结合在本公开中。
技术领域
本发明实施例涉及生命科学技术领域，例如涉及一种生物体刺激装置及系统。
背景技术
在动物受到应激刺激后，大脑启动一系列行为、生理和内分泌反应应对外界刺激。束缚应激刺激是一种典型的生理，物理应激刺激方式，在研究压力应激中经常被用来作为模型。目前，在相关技术的刺激生物体(例如，小鼠)的方案中，都是先束缚装置进行束缚应激刺激，再使用其他装置(例如，光刺激装置)进行其他刺激(例如，光刺激)，以获取生物体特征参数。
然而，相关技术的刺激方案中，由于两次不同的刺激存在时间差，会导致生物体特征参数的获取不够准确。
发明内容
本发明实施例提供一种生物体刺激装置及系统，以实现在进行束缚应激刺激的同时提供其他刺激，准确地获取生物体特征参数的效果。
第一方面，本发明实施例提供了一种生物体刺激装置，包括：
刺激部件，所述刺激部件的第一端植入生物体的头部，所述刺激部件的第二端暴露在空气中，所述刺激部件用于使所述生物体产生第一应激反应；
束缚部件，所述束缚部件包括第一孔，所述刺激部件穿过所述第一孔，所述束缚部件用于束缚生物体的行动，以使所述生物体产生第二应激反应。
可选的，还包括：
固定部件，所述固定部件包括一个通孔，所述通孔包裹所述刺激部件的中间部位，所述固定部件的一端与头部表面贴合。
可选的，所述束缚部件还包括第二孔，所述第二孔用于将所述生物体部分暴露在空气中。
可选的，所述刺激部件包括光纤和微导管中至少之一，所述光纤用于给所 述生物体提供光刺激，所述微导管用于给所述生物体提供药物刺激。
可选的，所述束缚部件为软性材质。
可选的，所述束缚部件为圆柱形状。
第二方面，本发明实施例提供了一种文本信息的检索装置，包括：
刺激传导装置，所述刺激传导装置被配置为将刺激传导至所述刺激部件的第二端；
刺激发生装置，所述刺激发生装置被配置为提供刺激来源并传输给所述刺激传导装置。
可选的，所述刺激传导装置为光纤，所述刺激发生装置为光源，所述光源被配置为提供光刺激。
可选的，还包括：
波形发生器，所述波形发生器的输入端与所述光源连接，所述波形发生器的输出端与所述光纤连接，所述波形发生器被配置为调节光刺激的波形；
所述光源通过所述波形发生器将光刺激传输给光纤。
可选的，所述光源为发光二极管LED或激光。
本发明实施例通过刺激部件，所述刺激部件的第一端植入生物体的头部，所述刺激部件的第二端暴露在空气中，所述刺激部件用于使所述生物体产生第一应激反应；束缚部件，所述束缚部件包括第一孔，所述刺激部件穿过所述第一孔，所述束缚部件用于束缚生物体的行动，以使所述生物体产生第二应激反应，解决了，由于两次不同的刺激存在时间差，会导致生物体特征参数的获取不够准确的问题，实现了在进行束缚应激刺激的同时提供其他刺激，准确地获取生物体特征参数。
附图说明
图1为本发明实施例一提供的一种生物体刺激装置的结构示意图；
图2为本发明实施例一提供的一种生物体刺激装置的结构示意图；
图3为本发明实施例一提供的一种生物体刺激装置的结构示意图；
图4为本发明实施例二提供的一种生物体刺激系统的结构示意图；
图5为本发明实施例二提供的一种生物体刺激系统的结构示意图。
具体实施方式
下面结合附图和实施例对本申请作进一步的详细说明。可以理解的是，此处所描述的具体实施例仅仅用于解释本申请，而非对本申请的限定。另外还需要说明的是，为了便于描述，附图中仅示出了与本申请相关的部分而非全部结构。
此外，术语“第一”、“第二”等可在本文中用于描述各种方向、动作、步骤或元件等，但这些方向、动作、步骤或元件不受这些术语限制。这些术语仅用于将第一个方向、动作、步骤或元件与另一个方向、动作、步骤或元件区分。举例来说，在不脱离本申请的范围的情况下，可以将第一应激反应为第二应激反应，且类似地，可将第二应激反应称为第一应激反应。第一应激反应和第二应激反应两者都是应激反应，但其不是同一应激反应。术语“第一”、“第二”等而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有“第一”、“第二”的特征可以明示或者隐含地包括一个或者更多个该特征。在本申请的描述中，“多个”的含义是至少两个，例如两个，三个等，除非另有明确具体的限定。
实施例一
图1为本发明实施例一提供的生物体刺激装置的结构示意图。如图1所示，本发明实施例提供了一种生物体刺激装置10，包括刺激部件100和束缚部件200。本实施例的生物体刺激装置10用于对生物体同时进行多种刺激。其中：
所述刺激部件100的第一端110植入生物体的头部，所述刺激部件100的第二端120暴露在空气中，所述刺激部件100用于使所述生物体产生第一应激反应；
所述束缚部件200包括第一孔210，所述刺激部件100穿过所述第一孔210，所述束缚部件200用于束缚生物体的行动，以使所述生物体产生第二应激反应。
在本实施例中，刺激部件100可以包括光刺激部件、药物刺激部件等。光刺激部件用于提供光刺激，药物刺激部件用于提供药物刺激。第一应激反应是指因刺激部件100进行刺激产生的应激反应。生物体可以包括小鼠，猴子等。可选的，生物体为小鼠。束缚部件200用于束缚生物体的行动，使生物体产生第二应激反应，则第二应激反应也可以看作是束缚应激反应。束缚应激刺激是一种典型的生理，物理应激刺激方式，在研究压力应激中经常被用来作为模型。
在一些实施例中，刺激部件100包括第一端110和第二端120。刺激部件 100的第一端110植入生物体的头部，刺激部件100的第二端120暴露在空气中。刺激来源(例如，光刺激、药物刺激)通过刺激部件100的第二端120输入，经过刺激部件100的传导到达刺激部件100的第一端110，由于刺激部件100的第一端110植入生物体的头部，则刺激来源可以通过刺激部件100进入生物体，例如小白鼠的大脑，进而给大脑提供刺激。
可选的，刺激部件100为光刺激部件时，则刺激部件100为光纤；刺激部件100为药物刺激部件时，刺激部件100为微导管。光纤用于给所述生物体提供光刺激，微导管用于给所述生物体提供药物刺激。在一些实施例中，刺激部件100可以只包括光刺激部件或药物刺激部件，也可以同时包括药物刺激部件和光刺激部件，即刺激部件100可以只包括光纤或微导管，也可以同时包括光纤和微导管。光纤用于传导光信号，微导管用于传导药物。可选的，在本实施例中，刺激部件100为光纤，用于提供光刺激。即在研究模式动物小鼠的束缚应激刺激机理中，同时利用光遗传学干预小鼠的神经环路。
在一些实施例中，束缚部件200包括第一孔210，刺激部件100穿过第一孔210，则刺激部件100的第一端110在束缚部件200的内部并植入到生物体的头部。在进行束缚应激刺激时，需要束缚部件200是封闭的，通过在束缚部件200上设置第一孔210，刺激部件100的直径大小与第一孔210刚好配合，且刺激部件100的第二端120暴露在空气中，使得在进行束缚应激刺激的同时，可以通过刺激部件100的第二端120输入其他刺激，并且不影响束缚应激刺激的执行，实现了同时执行束缚应激刺激和其他刺激。
可选的，束缚部件200为三棱柱或圆柱形状。在一些实施例中，束缚部件200为圆柱形状，即束缚筒。
可选的，束缚部件200为软性材质。软性材质可以包括软塑料或软布料。将软塑料或软布料进行缠绕几圈，以支撑束缚部件200。
参考图2，图2为一种生物体刺激装置10的结构示意图。在一可选的实施方式中，束缚部件200还包括第二孔220，第二孔220用于将所述生物体部分暴露在空气中。
其中，生物体部分是指生物体的一部分，通过该生物体部分可以采集生物体特征参数(例如，血液)。可选的，生物体部分为生物体的尾部，例如小鼠的尾部或猴子的尾部。可选的，第二孔220的大小与生物体部分的大小相适应。在一些实施例中，当生物体部分为尾部时，则第二孔220直径大小与第二孔220 的直径大小一致。通过在束缚部件200设置一个第二孔220，将生物体部分暴露在空气中，则可以在提供刺激时或刺激后，直接在暴露在空气中的生物体部分采集生物体特征参数，不需要把生物体取出来即可采集生物体特征参数，提高了采集参数的便利性。此外，还可以在进行刺激的同时采集生物体特征参数，判断生物体特征参数的变化，提高了采集生物体特征参数的准确性。
参考图3，图3为一种生物体刺激装置10的结构示意图。在另一可选的实施方式中，生物体刺激装置10还包括固定部件300。其中：
所述固定部件300包括一个通孔310，所述通孔310包裹所述刺激部件100的中间部位，所述固定部件300的一端与头部表面贴合。
其中，固定部件300的一端为适配生物体头部表面的平面或曲面。固定部件300的一端和头部表面贴合。并且，该固定部件300包括一个通孔310，贯穿固定部件300，刺激部件100通过该通孔310，将刺激部件100的第一端110植入到生物体的头部，而刺激部件100的第二端120暴露在空气中。通孔310包裹刺激部件100的中间部位，即包括刺激部件100的第一端110和刺激部件100的第二端120之间的部分。可选的，通孔310的大小与刺激部件100的直径大小一致或略大于刺激部件100的直径大小。通过设置一个固定部件300，该固定部件300包括一个通孔310，固定部件300的一端与头部表面贴合，刺激部件100通过该通孔310将第一端110植入到生物体的头部内，由于固定部件300的一端与头部表面贴合，通孔310包裹着该刺激部件100，可以防止刺激部件100晃动，提高了操作的便利性。
本发明实施例的技术方案，通过刺激部件，所述刺激部件的第一端植入生物体的头部，所述刺激部件的第二端暴露在空气中，所述刺激部件用于使所述生物体产生第一应激反应；束缚部件，所述束缚部件包括第一孔，所述刺激部件穿过所述第一孔，所述束缚部件用于束缚生物体的行动，以使所述生物体产生第二应激反应，可以在进行束缚应激刺激的同时提供其他刺激，实现了准确地获取生物体特征参数。
实施例二
图4为本发明实施例二提供的生物体刺激系统的结构示意图。如图4所示，本发明实施例提供了一种生物体刺激系统，包括生物体刺激装置10、刺激传导装置20和刺激发生装置30。本实施例的生物体刺激系统用于对生物体同时进行 多种刺激。其中：
生物体刺激装置10用于对生物体进行刺激；
所述刺激传导装置20用于将刺激传导至所述刺激部件的第二端；
所述刺激发生装置30用于提供刺激来源并传输给所述刺激传导装置20。
在本实施例中，刺激发生装置30可以是光刺激发生装置30，也可以是药物刺激发生装置30。刺激传导装置20与刺激发生装置30相关。例如，当刺激发生装置30为光源时，刺激传导装置20为光纤，用于将光刺激从光源传导至生物体刺激装置10中刺激部件的第二端，以将光刺激传导至生物体的头部。
可选的，刺激发生装置30是光刺激发生装置30，即刺激发生装置30为光源，光源用于提供光刺激。
在一些实施例中，刺激发生装置30提供刺激来源并将刺激来源传输给刺激传导装置20，刺激传导装置20再将刺激来源传导至生物体刺激装置10中刺激部件的第二端，从而将刺激通过刺激部件传导给生物体的头部，从而在提供束缚应激刺激的同时提供其他刺激。以刺激传导装置20是光纤、刺激发生装置30是光源和刺激部件是光纤为例，光源产生光刺激，通过刺激传导装置20(光纤)传导至生物体刺激装置10中刺激部件(光纤)的第二端，从而传导给生物体的头部。
可选的，光源为固定波长的光。在一些实施例中，光源为发光二极管LED或激光。
参考图5，在一可选的实施方式中，该生物体刺激系统还包括波形发生器40。
所述波形发生器40的输入端与所述光源31连接，所述波形发生器40的输出端与所述光纤21连接，用于调节光刺激的波形；所述光源31通过所述波形发生器40将光刺激传输给光纤21。
其中，波形发生器40用于调节光刺激的波形，即调节光信号的波形。在一些实施例中，调节光信号的波形包括稳定光信号的波长、形成特定的波长和控制光信号的幅度等。形成特定的波长的目的是满足不同状态下的刺激的需求。增强光信号的幅度的目的是增大光信号的幅度，使得刺激效果更明显。
在本实施方式中，增加了波形发生器40，光源31通过波形发生器40将光刺激传输给光纤21，经过波形发生器40处理的光刺激，光刺激的波长、幅度进行了一定的调整，形成了一个稳定、特定的波形，则输出至光纤21的光刺激的 波形是稳定的，再传输给生物体刺激装置10，通过刺激部件将稳定的光刺激传导到生物体的头部，使得刺激的效果更好。
本发明实施例的技术方案，通过刺激部件，所述刺激部件的第一端植入生物体的头部，所述刺激部件的第二端暴露在空气中，所述刺激部件用于使所述生物体产生第一应激反应；束缚部件，所述束缚部件包括第一孔，所述刺激部件穿过所述第一孔，所述束缚部件用于束缚生物体的行动，以使所述生物体产生第二应激反应，可以在进行束缚应激刺激的同时提供其他刺激，实现准确地获取生物体特征参数。

Claims (10)

  1. 一种生物体刺激装置，包括：
    刺激部件，所述刺激部件的第一端植入生物体的头部，所述刺激部件的第二端暴露在空气中，所述刺激部件用于使所述生物体产生第一应激反应；
    束缚部件，所述束缚部件包括第一孔，所述刺激部件穿过所述第一孔，所述束缚部件用于束缚生物体的行动，以使所述生物体产生第二应激反应。
  2. 如权利要求1所述的生物体刺激装置，所述生物体刺激装置还包括：
    固定部件，所述固定部件包括一个通孔，所述通孔包裹所述刺激部件的中间部位，所述固定部件的一端与头部表面贴合。
  3. 如权利要求1所述的生物体刺激装置，其中，所述束缚部件还包括第二孔，所述第二孔用于将所述生物体部分暴露在空气中。
  4. 如权利要求1所述的生物体刺激装置，其中，所述刺激部件包括光纤和微导管中至少之一，所述光纤用于给所述生物体提供光刺激，所述微导管用于给所述生物体提供药物刺激。
  5. 如权利要求1所述的生物体刺激装置，其中，所述束缚部件为软性材质。
  6. 如权利要求1所述的生物体刺激装置，其中，所述束缚部件为圆柱形状。
  7. 一种生物体刺激系统，包括如权利要求1-6任一项所述的生物体刺激装置，所述生物体刺激系统还包括：
    刺激传导装置，所述刺激传导装置被设置为将刺激传导至所述刺激部件的第二端；
    刺激发生装置，所述刺激发生装置被设置为提供刺激来源并传输给所述刺激传导装置。
  8. 如权利要求7所述的生物体刺激系统，其中，所述刺激传导装置为光纤，所述刺激发生装置为光源，所述光源被设置为提供光刺激。
  9. 如权利要求8所述的生物体刺激系统，所述生物体刺激系统还包括：
    波形发生器，所述波形发生器的输入端与所述光源连接，所述波形发生器的输出端与所述光纤连接，所述波形发生器被设置为调节光刺激的波形；
    所述光源通过所述波形发生器将光刺激传输给光纤。
  10. 如权利要求8所述的生物体刺激系统，其中，所述光源为发光二极管LED或激光。
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