WO2021045140A1 - Dispositif de traitement d'informations, système de mesure d'onde d'impulsion et programme de mesure d'onde d'impulsion - Google Patents

Dispositif de traitement d'informations, système de mesure d'onde d'impulsion et programme de mesure d'onde d'impulsion Download PDF

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Publication number
WO2021045140A1
WO2021045140A1 PCT/JP2020/033394 JP2020033394W WO2021045140A1 WO 2021045140 A1 WO2021045140 A1 WO 2021045140A1 JP 2020033394 W JP2020033394 W JP 2020033394W WO 2021045140 A1 WO2021045140 A1 WO 2021045140A1
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Prior art keywords
pulse wave
information processing
subject
unit
image
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PCT/JP2020/033394
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English (en)
Japanese (ja)
Inventor
基史 祖父江
昌弘 川村
忠志 西川
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株式会社ナノルクス
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Priority to JP2021544020A priority Critical patent/JPWO2021045140A1/ja
Priority to CN202080059292.XA priority patent/CN114270399A/zh
Publication of WO2021045140A1 publication Critical patent/WO2021045140A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis

Definitions

  • the present invention relates to an information processing device, a pulse wave measurement system, and a program that detect a pulse wave from an image or signal of a subject.
  • Patent Document 1 discloses a device that calculates a difference in luminance information from images taken at different parts of a subject's body taken at the same time and measures a change in blood pressure according to an increase or decrease in the difference. There is.
  • the RGB signal extracted from the acquired measurement target person image is converted into a YCbCr signal, and the face region and the target region ROI are detected from the luminance signal Y. Then, from the Cb + Cr signal acquired from the extracted target region ROI, a Cb + Cr trace signal in which the value at an arbitrary time is plotted is generated to detect the pulse wave.
  • Patent Document 4 discloses a method of detecting a pulse wave by using an information terminal such as a smartphone.
  • Patent Document 1 needs to obtain captured images of different parts of the subject's body at the same time, but depending on the posture, clothes, camera position, etc. of the subject, the subject's body at the same time. It can be difficult to obtain captured images of different parts of the body. Further, the techniques described in Patent Documents 2 and 3 are inferior in versatility because the apparatus configuration becomes large, and are not suitable for daily use.
  • Patent Document 4 is suitable for daily use because information is acquired by a smartphone, but the pulse wave is calculated from the image of the fingertip, so that the detection accuracy is improved. There are challenges.
  • an object of the present invention is to provide a highly accurate and general-purpose information processing device, a pulse wave measurement system, and a pulse wave measurement program.
  • the information processing apparatus includes an extraction unit that extracts data in a specific range from the brightness value distribution of the target person's skin region included in an image of the target person based on the peak value, and the extraction unit.
  • a normalization unit that normalizes the data so that the peak height becomes 1
  • a calculation unit that calculates the standard deviation with respect to the normalized data, and the standard deviation are arranged in chronological order. It has an output unit that outputs the pulse wave of the subject.
  • the information processing device of the present invention may further have a receiving unit for receiving the photographed image from the photographing device.
  • the output unit can also output the pulse wave of the subject to an external device.
  • the information processing apparatus of the present invention may have a removing portion for removing the luminance unevenness of the skin region of the subject included in the image, and in that case, the extracting portion may have the luminance unevenness due to the removing portion.
  • the data is extracted from the removed luminance value distribution.
  • the removal unit divides the skin region into a plurality of regions, calculates a luminance value distribution for each of the divided regions, aligns the peak position of each luminance value distribution with a reference position, and sums all the luminance value distributions. It is also possible to obtain the brightness value distribution from which the brightness unevenness is removed.
  • the image may be taken by using two or more near-infrared lights having different wavelengths, and in that case, the extraction unit may distribute the brightness value of the near-infrared light component. Extract data from.
  • the skin region of the subject included in the captured image is divided into a plurality of regions, the standard deviation of the brightness value is obtained for each of the divided plurality of regions, and the obtained standard deviation is constant. The presence or absence of the subject's pulse is determined based on the proportion of the region below the value.
  • the pulse wave measurement system includes a photographing device for photographing a skin area of a subject and an information processing device described above.
  • the photographing device may include a solid-state imaging device that detects at least two or more near-infrared lights having different wavelengths, and may transmit an image containing the near-infrared light component to the information processing device.
  • the pulse wave measurement program has an extraction function for extracting data in a specific range from the brightness value distribution of the skin region of the subject included in an image of the subject, and the above-mentioned.
  • a normalization function that normalizes the peak height to 1
  • a calculation function that calculates the standard deviation for the normalized data, and the standard deviations are arranged in chronological order.
  • the computer is made to execute the output function of outputting the pulse wave of the subject.
  • an information processing device a pulse wave measurement system, and a pulse wave measurement program that can detect pulse waves with high accuracy and have high versatility.
  • FIG. 1 A is a diagram showing a range of data extracted from the luminance value histogram in the extraction unit 302 shown in FIG. 3, and B is a diagram showing the extracted data.
  • a and B are diagrams showing the data normalization process in the normalization unit 303 shown in FIG. 3, where A shows the state before the normalization process and B shows the state after the normalization process.
  • FIG. 1 It is a figure which shows the output example from the output part 303. It is a block diagram which shows the structural example from the functional aspect of the information processing apparatus in the pulse wave measurement system of the 1st modification of 1st Embodiment of this invention. It is a flowchart which shows the processing process in the information processing apparatus 101 shown in FIG. It is a figure which shows the data before surface division in a luminance unevenness removal step (S12). It is a figure which shows the data after surface division in a luminance unevenness removal step (S12). It is a figure which shows the data before the peak position adjustment in a luminance unevenness removal step (S12). It is a figure which shows the data after the peak position adjustment in a luminance unevenness removal step (S12). It is a figure which shows the luminance value histogram after the luminance unevenness removal processing.
  • FIG. 1 is a block diagram showing a configuration example of the pulse wave measurement system of the present embodiment.
  • the pulse wave measurement system of the present embodiment includes a photographing device 110 and an information processing device 100, and the photographing device 110 and the information processing device 100 can communicate with each other via wired or wireless communication. It is connected.
  • the photographing device 110 photographs the skin region of the subject and generates a captured image including the skin region.
  • the photographing device 110 transmits the generated photographed image to the information processing device 100.
  • a dedicated camera may be used for the photographing device 110, but a camera built in the mobile information terminal or a camera installed in the vehicle or indoors for other purposes can also be used.
  • the information processing device 100 processes the captured image received from the photographing device 110 and outputs a pulse wave.
  • the pulse wave is detected from the fluctuation of the brightness average value of the skin region of the subject included in the captured image, but in the pulse wave measurement system of the present embodiment, the skin region of the subject is detected. Focusing on the histogram of the brightness value of, the pulse wave is detected from the shape change.
  • FIG. 2 is a block diagram showing an example of the hardware configuration of the information processing device 100.
  • the information processing device 100 can be configured to include, for example, a control unit 201, a storage unit 202, an input unit 203, a display unit 204, and a communication unit 205.
  • the control unit 201 controls the entire information processing device 100, and a CPU (Central Processing Unit) or the like can be used.
  • a CPU Central Processing Unit
  • the storage unit 202 stores a program for executing processing, data used when the control unit 201 executes processing based on the program, and the like, and is an HDD (Hard Disk Drive), ROM (Read Only Memory). , RAM (Random Access Memory) or the like is used. Then, the control unit 201 executes the process based on the program stored in the storage unit 202, thereby realizing the functions and processes of the information processing device 100 described later.
  • HDD Hard Disk Drive
  • ROM Read Only Memory
  • RAM Random Access Memory
  • the input unit 203 inputs the user's operation to the control unit 201, and is composed of buttons and the like.
  • the display unit 204 displays the processing result of the control unit 201 and the like, and a display device such as a display can be used.
  • the communication unit 205 connects the information processing device 100 to the network, and a NIC (Network Interface Card) or the like is used.
  • NIC Network Interface Card
  • FIG. 3 is a block diagram showing a configuration example from the functional aspect of the information processing apparatus 100.
  • the information processing apparatus 100 when it is viewed from the functional aspect, it can be configured to include a receiving unit 301, an extracting unit 302, a normalizing unit 303, a calculating unit 304, and an output unit 305.
  • the receiving unit 301 receives the captured image from the photographing device 110, and the extracting unit 302 uses the peak value as a reference from the luminance value histogram of the target person's skin area included in the captured image received by the receiving unit 301 to specify a range. Extract the data of.
  • the luminance value histogram is an example of the luminance value distribution.
  • the normalization unit 303 normalizes the data extracted by the extraction unit 302 so that the peak height becomes a predetermined value.
  • the calculation unit 304 calculates the standard deviation of the data normalized by the normalization unit 303.
  • the output unit 305 arranges the standard deviations calculated by the calculation unit 304 in chronological order and outputs and displays them as pulse waves of the target person, for example, on the display unit 204 or transmits them to an external device via the communication unit 205. To do.
  • the pulse wave measurement system of the present embodiment First, an image including the skin of the subject is photographed by the photographing device 110, and the photographed image is transmitted to the information processing device 100. Next, in the information processing apparatus 100, the pulse wave is measured by capturing the peak position of the luminance value histogram and capturing the shape change of the luminance value histogram. In order to capture the shape change of the histogram of the luminance value, the information processing apparatus 100 uses the standard deviation of the data related to the histogram of the luminance value as a feature amount, and detects the pulse wave by the fluctuation of the standard deviation.
  • FIG. 4 is a flowchart showing a processing process in the information processing apparatus 100. Specifically, as shown in FIG. 4, in the information processing apparatus 100, when the receiving unit 301 receives the captured image (step S1), the extraction unit 302 includes a luminance value histogram of the skin region of the target person included in the captured image. Then, data in a specific range is extracted with reference to the peak value (step S2).
  • FIG. 5A is a diagram showing a range of data extracted from the luminance value histogram by the extraction unit 302
  • FIG. 5B is a diagram showing the extracted data.
  • the peak value of the luminance value histogram is set to 100%, and data in the range up to n% (the range surrounded by the ellipse in FIG. 5A) is extracted.
  • the data shown in FIG. 5B is extracted.
  • the range of the data to be extracted (n% value shown in FIG. 5A) can be appropriately set according to the shape of the luminance value histogram and the like.
  • FIG. 6A and 6B are diagrams showing the data normalization process in the normalization unit 303, FIG. 6A shows the state before the normalization process, and FIG. 6B shows the state after the normalization process.
  • the normalization unit 303 performs normalization so that the peak amount H of the extracted data shown in FIG. 6A is 1, for example. As a result, the data shown in FIG. 6B can be obtained. By performing this normalization process, it is possible to capture only the change in shape by the standard deviation without depending on the number of extracted data.
  • the calculation unit 304 calculates the standard deviation of the normalized data (step S4).
  • the result (standard deviation) is arranged in chronological order to form a waveform, which is output from the output unit 305 as a pulse wave of the subject (step S5).
  • FIG. 7 is a diagram showing an example of output from the output unit 303.
  • the processing result of the information processing apparatus 100 is generated, for example, on the display unit 204 by arranging the captured image showing the skin region used for pulse wave detection and the standard deviation in chronological order as shown in FIG. It is also possible to display the pulse wave side by side.
  • Each of the above-mentioned steps can be carried out by creating a computer program for realizing the functions of each part of the information processing apparatus 100 and implementing it on one or more computers. That is, an extraction function that extracts data in a specific range based on the peak value from the brightness value distribution of the target person's skin area included in the image of the target person, and a predetermined peak height for the extracted data. A normalization function that normalizes to the value of, a standard deviation calculation function that calculates the standard deviation for the normalized data, and a pulse wave that outputs the pulse wave of the subject by arranging the standard deviation in chronological order.
  • a program that causes a computer to execute an output function can be executed by operating the computer or an image processing device.
  • the pulse wave detection system of the present embodiment simplifies the device because it is not necessary to capture a plurality of images and the pulse wave of the target person can be detected from the captured images at one place. It can be used and is highly versatile.
  • a method of determining a measurement target area and detecting a pulse by averaging the brightness in the area is adopted. This method utilizes the fact that the brightness level decreases when blood is flowing by taking the average value in time series because hemoglobin in the blood absorbs light, but the absorption of light is slight. Since the change in the average luminance value is a fluctuation at a level of 1/10 or less, it is vulnerable to the movement of an object and the fluctuation of ambient light.
  • the pulse wave detection system of the present embodiment extracts data in a specific range, normalizes it, and takes a standard deviation, so that it is not easily affected by the movement of an object or fluctuation of ambient light. , The pulse wave can be detected with high accuracy. Further, in general, processing such as standard deviation and dispersion is performed on a pixel-by-pixel basis, and there is a concern that the processing speed may decrease. However, since the pulse wave detection system of the present embodiment uses a luminance value histogram, the processing speed is high. Processing speed is possible.
  • the pulse wave measurement system of this embodiment can be mounted on a car, for example.
  • the skin region of the driver and / or the passenger is photographed by the photographing device 110, the photographed image is processed by the information processing device 100, and the pulse wave of the driver and / or the passenger is detected and output. This makes it possible to detect changes in the physical condition of the driver or the like.
  • the photographing device 110 and the information processing device 100 are separate bodies, but the present invention is not limited to this, and the photographing device 110 and the information processing device 100 are integrated. It may be configured.
  • the function of the information processing device 100 described above may be mounted on the photographing device 110, or both the function of the processing device 100 and the function of the photographing device 110 may be mounted on the information terminal information with a camera.
  • FIG. 7 shows an example in which a part of the captured image is used as the detection area
  • the present invention is not limited to this, and the entire field of view of the photographing device 110 may be set as the detection area.
  • the processing by the information processing apparatus 100 may take time. Therefore, even if the subject is irradiated with infrared light, the reflecting light of the infrared light is detected by the photographing device 110, and the detection region (for example, the skin region of the subject) is automatically followed based on the amount of the light. Good. As a result, the processing time in the information processing apparatus 100 can be shortened.
  • FIG. 8 is a block diagram showing a configuration example from the functional aspect of the information processing device in the pulse wave measurement system of this modified example
  • FIG. 9 is a flowchart showing a processing process in the information processing device 101 shown in FIG.
  • the same components as those of the information processing apparatus 100 shown in FIG. 3 are designated by the same reference numerals, and detailed description thereof will be omitted.
  • the information processing device 101 is provided with a removal unit 801 in addition to the reception unit 301, the extraction unit 302, the normalization unit 304, and the output unit 305. There is.
  • step S11 after the captured image is received by the receiving unit 301 of the information processing device 101 (step S11) and the brightness unevenness of the captured image is removed by the removing unit 801 (step S12).
  • the extraction unit 302 data in a specific range is extracted from the luminance value histogram from which the luminance unevenness has been removed, with reference to the peak value (step S13).
  • the normalization unit 303 performs the normalization process (step S14), and the calculation unit 304 calculates the standard deviation (step S15), and the obtained results are arranged in chronological order and output from the output unit 305 as a pulse wave. (Step S16).
  • the removing unit 801 removes the uneven brightness of the skin region of the subject included in the captured image.
  • 10 to 14 are diagrams for explaining the luminance unevenness removing process (luminance unevenness removing step S12) by the removing unit 801.
  • the removing unit 801 divides the skin area (detection area) of the captured image into N pieces.
  • N is a natural number of 2 or more
  • each divided detection region has a size that allows the peak of the luminance histogram to be known.
  • a luminance value histogram is calculated for each divided detection region.
  • the removal unit 801 determines for each divided detection region whether or not the region can be used for pulse wave measurement or the like based on the shape of the luminance value histogram.
  • the peak positions are adjusted to align the luminance peak positions for each luminance value histogram with the reference positions, the sum of all N histograms is calculated, and the sum of the sums shown in FIG. 14 is calculated.
  • Get the data That is, the removal unit 801 creates a luminance value histogram of the entire region by combining and adding the corrected luminance value histograms. As a result, a luminance value histogram in which the luminance unevenness is removed can be obtained.
  • data in a specific range is extracted by the extracting section 3023 with reference to the peak value.
  • the detection area is divided, the brightness value histogram is calculated for each divided area, the peak position is adjusted, and then all the data are summed and combined.
  • a luminance value histogram without is obtained.
  • the light source is arranged in a fixed place as in infrared photography, and the level of reflected light fluctuates depending on the angle of the surface exposed to the light, such as when the subject is irradiated with light in a spot. Is particularly effective when using.
  • the configurations and effects other than the above in the pulse wave measurement system of this modified example are the same as those in the first embodiment described above.
  • the control unit 201 calculates the standard deviation of the brightness value for each of the surface-divided small regions, and determines the presence or absence of a pulse in each frame. Since the magnitude of the standard deviation indicates the degree of light reflection unevenness, the region of the luminance standard deviation larger than a certain value is a portion where the pulse component cannot be extracted well. Therefore, the control unit 201 determines that there is a pulse in the corresponding hum when the ratio of the small region in which the pulse component is successfully extracted to the whole is larger than the predetermined value, and when it is less than the predetermined value, it corresponds. Judge that there is no pulse in the humming.
  • the control unit 201 divides the skin region of the subject included in the captured image into a plurality of regions, obtains the standard deviation of the brightness value for each of the divided plurality of regions, and the obtained standard deviation is a region of a certain value or less. Based on the ratio of, the presence or absence of the subject's pulse is determined and output.
  • the pulse wave measurement system of the present embodiment can determine the presence or absence of a pulse.
  • the configurations and effects of the pulse wave measurement system of the present embodiment other than the above are the same as those of the first embodiment described above.
  • the pulse wave measurement system of the present embodiment uses an image pickup device equipped with an image pickup element capable of detecting two or more near-infrared lights having a wavelength different from that of the visible light detection pixel, and has a wavelength in addition to the visible light image.
  • a near-infrared light image taken by two or more different near-infrared lights is taken.
  • the imaging elements used at that time include, for example, three types of visible light pixels having different detection wavelengths described in International Publication No. 2018/155486 and International Publication No. 2018/207817, and two or more types having different detection wavelengths.
  • Examples include those in which near-infrared light pixels are provided on the same substrate, but the present invention is not limited to these, and in addition to red light R, green light G, and blue light B, two or more types having different wavelengths are used. Anything that can detect near-infrared light (multi-spectrum of near-infrared light) is sufficient.
  • the visible light pixel detects red light R, green light G, and blue light B
  • the near-infrared light pixel detects near-infrared light that correlates with R, near-infrared light that correlates with G, and B.
  • the image was taken with normal illuminance not only in an environment where the amount of visible light is small, but also in an environment where there is no visible light such as darkness (0 lux). It is possible to take an image having the same information as the case.
  • the subject in the pulse wave measurement system of the present embodiment, can be photographed in a wide range of illuminance environments from normal illuminance to darkness (0 lux), and the pulse wave can be measured accurately regardless of the environment in which the subject is present. Is possible.
  • the information processing apparatus 100 receives, for example, a color image generated from visible light, near-infrared light, or both of them from the photographing apparatus 110, and each component included in the color image is included.
  • the pulse wave is detected from the brightness value histogram.
  • pulse waves may be detected from changes in the ratio, difference, and logarithm (Log) of two near-infrared light components having different wavelengths.
  • the detection signals of two types of near-infrared light having different wavelengths detected by the image sensor may be used as they are without generating a color image by the photographing apparatus.
  • the output unit outputs the pulse wave detected based on the multi-spectrum of the near infrared ray.
  • a pulse wave is generated by using two or more types of near-infrared light components having different wavelengths in addition to or in place of the visible light component. Since it is detected, the pulse wave can be detected more accurately.
  • the configurations and effects of the pulse wave measurement system of the present embodiment other than the above are the same as those of the first embodiment and its modifications described above.
  • the "part" may include, for example, a combination of hardware resources implemented by circuits in a broad sense and information processing of software that can be concretely realized by these hardware resources. .. Further, in this embodiment, various information is handled, and these information are represented by high and low signal values as a bit set of binary numbers composed of 0 or 1, and communication / calculation is executed on a circuit in a broad sense. Can be done.
  • a circuit in a broad sense is a circuit realized by at least appropriately combining a circuit (Circuit), circuits (Circuitry), a processor (Processor), a memory (Memory), and the like. That is, an integrated circuit for a specific application (Application Special Integrated Circuit: ASIC), a programmable logic device (for example, a simple programmable logic device (Simple Programmable Logical Device: SPLD), a composite programmable logic device (Complex Program)) It includes a programmable gate array (Field Programmable Gate Array: FPGA) and the like.

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Abstract

L'invention concerne un dispositif de traitement d'informations, un système de mesure d'onde d'impulsion et un programme de mesure d'onde d'impulsion qui sont extrêmement précis et largement applicables. La présente invention consiste à : transmettre, à un dispositif de traitement d'informations 100, une image (image capturée) d'un sujet capturé par un dispositif d'imagerie ; extraire, dans une unité d'extraction 302 du dispositif de traitement d'image 100, des données d'une plage spécifique de la distribution de valeurs de luminosité d'une zone de peau du sujet incluse dans l'image, la plage spécifique étant relative à une valeur de pic de la distribution de valeur de luminosité ; normaliser, dans une unité de normalisation 303, les données extraites de façon à avoir une hauteur de pic de un ; calculer, dans une unité de calcul 304, des écarts types par rapport aux données normalisées ; et ranger, dans une unité de sortie 305, les écarts types dans un ordre chronologique pour délivrer des ondes d'impulsion du sujet.
PCT/JP2020/033394 2019-09-03 2020-09-03 Dispositif de traitement d'informations, système de mesure d'onde d'impulsion et programme de mesure d'onde d'impulsion WO2021045140A1 (fr)

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JP2021544020A JPWO2021045140A1 (fr) 2019-09-03 2020-09-03
CN202080059292.XA CN114270399A (zh) 2019-09-03 2020-09-03 信息处理装置、脉搏波测量系统以及脉搏波测量程序

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014198202A (ja) * 2013-03-29 2014-10-23 富士通株式会社 脈波検出装置、脈波検出方法及び脈波検出プログラム
JP2014200390A (ja) * 2013-04-02 2014-10-27 富士通株式会社 脈波検出装置、脈波検出方法及び脈波検出プログラム
JP2016220915A (ja) * 2015-05-29 2016-12-28 株式会社リコー 脈波検出装置、脈波検出方法、脈波検出システム、及び、プログラム

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014198202A (ja) * 2013-03-29 2014-10-23 富士通株式会社 脈波検出装置、脈波検出方法及び脈波検出プログラム
JP2014200390A (ja) * 2013-04-02 2014-10-27 富士通株式会社 脈波検出装置、脈波検出方法及び脈波検出プログラム
JP2016220915A (ja) * 2015-05-29 2016-12-28 株式会社リコー 脈波検出装置、脈波検出方法、脈波検出システム、及び、プログラム

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