WO2021036738A1 - 离体器官灌注容器 - Google Patents
离体器官灌注容器 Download PDFInfo
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- WO2021036738A1 WO2021036738A1 PCT/CN2020/107631 CN2020107631W WO2021036738A1 WO 2021036738 A1 WO2021036738 A1 WO 2021036738A1 CN 2020107631 W CN2020107631 W CN 2020107631W WO 2021036738 A1 WO2021036738 A1 WO 2021036738A1
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- pipeline
- liquid
- isolated organ
- tank
- oxygenator
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
Definitions
- the present invention relates to the technical field of auxiliary medical devices, in particular to an isolated organ perfusion container.
- organ transplantation the preservation of the organ can directly determine the success or failure of the transplant operation.
- low-temperature static preservation is generally used to preserve the organs in vitro, that is, to extend the preservation time of the organs by reducing the energy consumption of the organs through low temperature.
- an isolated organ perfusion container By placing the isolated organ in the perfusion container and continuously infusing the isolated organ with the perfusion fluid, the isolated organ can be recovered in a normal temperature environment. Long-term storage can effectively avoid problems such as damage to tissue cells and organ ischemia caused by low-temperature environments, and improve the success rate of transplantation operations.
- the present invention provides an isolated organ perfusion container.
- the isolated organ perfusion container includes a cover, a tray, a supporting film, and a power pump head.
- the tray and the supporting film are arranged on the In the cover, the supporting film is fixedly arranged on the tray to support the organs in vitro, the bottom of the tray is provided with a liquid storage tank for containing the perfusion liquid, and the liquid storage tank is provided with a first liquid outlet,
- the supporting film is provided with a through hole for communicating with the liquid storage tank, the power pump head is used for connecting with the output end of the power pump, and the power pump head is provided with a port for connecting with the first liquid outlet.
- the first liquid inlet port connected with the pipeline and the first liquid outlet port used for communicating with the arterial pipeline of the isolated organ.
- the above-mentioned isolated organ perfusion container has at least the following beneficial effects: firstly, the isolated organ is placed on the supporting membrane, and the perfusion liquid is injected into the liquid storage tank, and then the first liquid inlet port of the power pump head Connect the first liquid outlet of the liquid storage tank through the pipeline, connect the first liquid outlet of the power pump head to the artery of the isolated organ through the pipeline, and then start the power pump, which drives the perfusion fluid in the pipeline After flowing out from the first outlet of the reservoir, the perfusate flows through the first inlet port, the first outlet port and the artery in sequence, and finally drains from the isolated organs and passes through the through holes of the supporting membrane Reflux into the liquid storage tank to realize the circulating flow of the perfusate, so as to continuously perfuse the isolated organs with the perfusate, so as to realize the long-term preservation of the isolated organs under the normal temperature environment, thereby effectively avoiding the low temperature environment.
- Tissue cells are damaged, organ ischemia and other problems; at the same time, the circulation of perfusion fluid is driven by a dynamic pump, which can effectively remove thrombus, inflammatory factors or other foreign harmful substances in the isolated organs, thereby maintaining the functional blood vessels of the isolated organs. , Which can improve pulmonary edema, improve the oxygenation capacity of the heart and lungs, etc., and can repair and treat isolated organs, reduce the risk of postoperative graft loss, and effectively increase the utilization rate of donor organs and the success rate of transplantation .
- it further includes an oxygenator connected between the first liquid outlet port and the artery through a pipeline, and the oxygenator is provided with a mixing device for communicating with the mixed gas source pipeline. Air interface.
- the oxygenator communicates with the heat exchange device through a pipeline to form a circulating heat exchange pipeline, and the perfusion liquid exchanges heat with the heat exchange liquid in the oxygenator.
- a leukocyte filter is further included, and the leukocyte filter is connected between the oxygenator and the artery through a pipeline.
- a micro-embolism filter is further included, and the micro-embolism filter is connected between the oxygenator and the artery or between the power pump head and the oxygenator through a pipeline.
- it further includes a waste liquid tank and a replenishing tank
- the liquid storage tank is also provided with a second liquid outlet
- the waste liquid tank is in communication with the second liquid outlet pipeline
- the waste The pipeline between the liquid tank and the second liquid outlet is provided with a second peristaltic pump for providing the perfusion liquid flowing from the second liquid outlet with power to flow into the waste liquid tank.
- the fluid replacement tank is in communication with the fluid storage tank pipeline, and the pipeline between the fluid replacement tank and the fluid storage tank is provided with a means for supplying the perfusion fluid flowing out of the fluid replacement tank into the fluid storage tank. Powered third peristaltic pump.
- it further includes a dialyzer, the dialyzer is connected between the second liquid outlet and the replenishing tank through a pipeline, and the second peristaltic pump is also used to transfer from the first The perfusate flowing out of the two liquid outlets provides power to flow through the dialyzer.
- the supporting film is recessed in a direction close to the liquid storage tank.
- the power pump head is detachably connected to the output end of the power pump.
- a pipe support is provided on the tray, and a plurality of bayonet holes for fixing the pipe are provided on the pipe support.
- Fig. 1 is a schematic structural diagram of an isolated organ perfusion container according to an embodiment of the present invention
- Fig. 2 is a schematic diagram of the internal structure of the isolated organ perfusion container shown in Fig. 1;
- FIG. 3 is a schematic diagram of the structure of the tray in the isolated organ perfusion container shown in FIG. 2;
- FIG. 4 is a schematic structural diagram of the power pump head in the isolated organ perfusion container shown in FIG. 1;
- Figure 5 is a partial cross-sectional view of the isolated organ perfusion container shown in Figure 1;
- Fig. 6 is a schematic structural diagram of the oxygenator in the isolated organ perfusion container shown in Fig. 2;
- FIG. 7 is a schematic diagram of the structure of the leukocyte filter in the isolated organ perfusion container shown in FIG. 2;
- FIG. 8 is a schematic diagram of the structure of the micro-plug filter in the isolated organ perfusion container shown in FIG. 2;
- Fig. 9 is a schematic diagram of the connection structure of the isolated organ perfusion container shown in Fig. 1.
- an isolated organ perfusion container is suitable for long-term preservation of isolated organs such as isolated lungs and isolated hearts in a normal temperature environment. It is also suitable for performing isolated organs For repair, the container includes a cover body 10, a tray 20, a supporting film 21, and a power pump head 30.
- the tray 20 and the supporting film 21 are arranged in the cover body 10, and the supporting film 21 is fixedly arranged on the tray 20 to support isolated organs,
- the bottom of the tray 20 is provided with a liquid storage tank 22 for accommodating the perfusion liquid
- the liquid storage tank 22 is provided with a first liquid outlet 221
- the support film 21 is provided with a through hole 211 for communicating with the liquid storage tank 22, and a power pump
- the head 30 is used to connect with the output end of the power pump (not marked in the drawings).
- the power pump head 30 is provided with a first liquid inlet port 31 for communicating with the first liquid outlet 221 pipeline and a The first liquid outlet port 32 communicated with the arterial pipeline of the organ.
- the circulation of the perfusion fluid driven by the power pump can effectively remove thrombus, inflammatory factors or other foreign harmful substances in the isolated organs, thereby maintaining the functional blood vessels of the isolated organs Unobstructed, which can improve pulmonary edema, improve heart and lung oxygenation capacity, etc., and can repair and treat isolated organs, reduce the risk of postoperative graft loss, and effectively improve the utilization of donor organs and the success of transplantation rate.
- FIG. 2 there are multiple through holes 211, and the multiple through holes 211 are evenly distributed on the supporting film 21.
- the perfusion solution is mixed with DMEM/F12 medium components, albumin and Ficoll in a 70 ratio.
- the above-mentioned isolated organ perfusion container further includes an oxygenator 40 connected between the first outlet port 32 and the artery through a pipeline, and the oxygenator 40 is provided with
- the mixed gas interface 43 is connected with the mixed gas source (not shown in the figure) pipeline.
- the power pump head 30, the oxygenator 40, the isolated organ and the liquid storage tank 22 are connected to form a circulating perfusion pipeline.
- the perfusion fluid is combined with the mixed gas in the oxygenator 40 to form an oxygenated perfusion fluid to ensure that the perfusion fluid flows into the artery.
- the oxygen content is sufficient.
- the oxygenator 40 communicates with a heat exchange device (not shown in the drawings) through a pipeline to form a circulating heat exchange pipeline, and the perfusion liquid exchanges heat with the heat exchange liquid in the oxygenator 40.
- the power pump head 30, the oxygenator 40, the isolated organs and the liquid storage tank 22 are connected to form a circulating perfusion pipeline.
- the perfusion fluid exchanges heat with the heat exchange fluid in the oxygenator 40 to maintain the temperature of the perfusion fluid and the isolated fluid.
- the organs are suitable.
- the oxygenator 40 is provided with a second liquid inlet port 41, a second liquid outlet port 42, a heat exchange inlet 44 and a heat exchange outlet 45, and the second liquid storage tank 22
- a liquid outlet 221 the first liquid inlet port 31 of the power pump head 30, the first liquid outlet port 32 of the power pump head 30, the second liquid inlet port 41, the second liquid outlet port 42 and the arteries of the isolated organs in sequence
- the pipeline is connected to form the above-mentioned circulating perfusion pipeline, and the heat exchange liquid outlet, the heat exchange inlet 44, the heat exchange outlet 45 and the heat exchange liquid inlet of the heat exchange device are connected in turn to form the aforementioned circulating heat exchange pipeline.
- the above-mentioned isolated organ perfusion container further includes a white blood cell filter 50, and the white blood cell filter 50 is connected between the oxygenator 40 and the artery through a pipeline.
- the perfusion fluid flows out from the oxygenator 40 and then enters the leukocyte filter 50 for leukocyte filtration, which effectively reduces the damage to the isolated organs due to the perfusion fluid perfusion. At the same time, it can effectively delay the occurrence of organ transplant rejection and further enhance the donor organs. The utilization rate and the success rate of transplant operations.
- the white blood cell filter 50 is provided with a third inlet port 51 and a third outlet port 52, the third inlet port 51 is in pipeline communication with the second outlet port 42, and the third The liquid outlet port 52 is in communication with the arterial pipeline of the isolated organ.
- the above-mentioned isolated organ perfusion container further includes a micro-embolic filter 60, which is connected between the oxygenator 40 and the artery through a pipeline or the power pump head 30 and the oxygenation ⁇ 40.
- the perfusate flows out from the oxygenator 40 and then enters the microembolism filter 60.
- the microembolism filter 60 is used to filter out various microembolisms in the perfusate, and prevent the ex vivo caused by various microembolisms such as thrombus or air embolism.
- the embolization of the capillaries of the organs effectively improves the blood perfusion of the capillaries of the human body, and further improves the utilization rate of the donor organs and the success rate of transplantation operations.
- the micro-plug filter 60 is provided with a fourth inlet 61 and a fourth outlet 62.
- the fourth inlet 61 is in pipeline communication with the second outlet 42.
- the four-outlet port 62 is in communication with the arterial pipeline of the isolated organ.
- FIG. 2 Please refer to FIG. 2 to combine the foregoing two embodiments to connect the white blood cell filter 50 and the micro-embolic filter 60 between the oxygenator 40 and the isolated organ at the same time.
- the white blood cell filter 50 and the micro-embolic filter The sequence of connection between the organs 60 is not limited, which further improves the utilization rate of the isolated organs and the success rate of the transplantation operation.
- the above-mentioned isolated organ perfusion container further includes a waste liquid tank 70 and a rehydration tank 80, and the liquid storage tank 22 is also provided with a second liquid outlet 222, and the waste liquid tank 70 and The second liquid outlet 222 is in communication with the pipeline, and the pipeline between the waste liquid tank 70 and the second liquid outlet 222 is provided with a device for providing the perfusion liquid flowing out of the second liquid outlet 222 to flow into the waste liquid tank 70
- the replenishment tank 80 is connected to the liquid storage tank 22 in pipeline, and the pipeline between the replenishment tank 80 and the liquid storage tank 22 is provided with a pipe for supplying the perfusion liquid flowing from the replenishment tank 80 into the liquid storage tank 22 Powered third peristaltic pump 81.
- the perfusion liquid after multiple cycles flows out from the second liquid outlet 222 of the liquid storage tank 22 and flows into the waste liquid tank 70 under the drive of the second peristaltic pump 71.
- the new perfusion liquid in the replenishment tank 80 is
- the third peristaltic pump 81 is driven to flow into the liquid storage tank 22 to realize supplemental replacement of the perfusion liquid, so as to ensure that the volume of the perfusion liquid in the liquid storage tank 22 is constant.
- the above-mentioned isolated organ perfusion container further includes a dialyzer 90, which is connected between the second liquid outlet 222 and the fluid replacement tank 80 through a pipeline, and the second peristaltic pump 71 also It is used to provide the perfusate flowing from the second liquid outlet 222 with power to flow through the dialyzer 90.
- the perfusion fluid flowing out from the second outlet 222 flows into the waste liquid tank 70, and the other part passes through the dialyzer 90 and merges with the new perfusion fluid flowing out of the refill tank 80. It flows into the liquid storage tank 22, which effectively reduces the loss of the perfusion liquid and saves the use cost.
- the supporting membrane 21 is recessed in the direction close to the reservoir 22, which provides more storage space for the isolated organs, and prevents the isolated organs from being compressed and damaged during the perfusion process.
- the supporting membrane 21 can Use a flexible soft membrane, such as a silicone mold, to further avoid damage to the isolated organs.
- the power pump head 30 is detachably connected to the output end of the power pump.
- the perfusion fluid flows inside the isolated organ perfusion container and does not come into contact with the power pump.
- the power pump head 30 can be detached from the power pump, and the isolated organ can be perfused into the container Disposal, when the next isolated organ perfusion operation is performed, replace the new isolated organ perfusion container and connect it with the power pump, so as to realize the one-time use of the isolated organ perfusion container and avoid every time the isolated organ perfusion is completed. The whole machine is replaced, effectively reducing the cost of use.
- a pipe support 23 is provided on the tray 20, and the pipe support 23 is provided with a plurality of bayonet holes for fixing the pipe.
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Abstract
Description
Claims (10)
- 一种离体器官灌注容器,其特征在于,所述的离体器官灌注容器包括:罩体、托盘、支撑膜和动力泵头,所述托盘和所述支撑膜设于所述罩体内,所述支撑膜固定设置在所述托盘上以支撑离体器官,所述托盘的底部设有用于容置灌注液的储液槽,所述储液槽设有第一出液口,所述支撑膜上开设用于与所述储液槽连通的通孔,所述动力泵头用于与动力泵的输出端连接,所述动力泵头设有用于与所述第一出液口管路连通的第一进液接口和用于与所述离体器官的动脉管路连通的第一出液接口。
- 根据权利要求1所述的离体器官灌注容器,其特征在于,还包括通过管路连接于所述第一出液接口和所述动脉之间的氧合器,所述氧合器上设有用于与混合气源管路连通的混合气接口。
- 根据权利要求2所述的离体器官灌注容器,其特征在于,所述氧合器通过管路与换热装置连通形成循环换热管路,所述灌注液在所述氧合器内与所述换热液进行热交换。
- 根据权利要求2所述的离体器官灌注容器,其特征在于,还包括白细胞过滤器,所述白细胞过滤器通过管路连接于所述氧合器与所述动脉之间。
- 根据权利要求2所述的离体器官灌注容器,其特征在于,还包括微栓过滤器,所述微栓过滤器通过管路连接于所述氧合器与所述动脉之间或所述动力泵头与所述氧合器之间。
- 根据权利要求1所述的离体器官灌注容器,其特征在于,还包括废液罐和补液罐,所述储液槽还设有第二出液口,所述废液罐与所述第二出液口管路连通,所述废液罐与所述第二出液口之间的管路上设有用于向从所述第二出液口流出的所述灌注液提供流入所述废液罐的动力的第二蠕动泵,所述补液罐与所述储液槽管路连通,所述补液罐与所述储液槽之间的管路上设有用于向从所 述补液罐流出的所述灌注液提供流入所述储液槽的动力的第三蠕动泵。
- 根据权利要求6所述的离体器官灌注容器,其特征在于,还包括透析器,所述透析器通过管路连通于所述第二出液口和所述补液罐之间,所述第二蠕动泵还用于向从所述第二出液口流出的所述灌注液提供流经所述透析器的动力。
- 根据权利要求1-7任一项所述的离体器官灌注容器,其特征在于,所述支撑膜向靠近所述储液槽方向凹陷。
- 根据权利要求1-7任一项所述的离体器官灌注容器,其特征在于,所述动力泵头与所述动力泵的输出端可拆卸地连接。
- 根据权利要求1-7任一项所述的离体器官灌注容器,其特征在于,所述托盘上设有管路支架,所述管路支架上设有多个用于固定管路的卡口。
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CN201910790498.9 | 2019-08-26 | ||
CN201921391975.6U CN210580687U (zh) | 2019-08-26 | 2019-08-26 | 离体器官灌注容器 |
CN201921391975.6 | 2019-08-26 | ||
CN201910790498.9A CN110506733A (zh) | 2019-08-26 | 2019-08-26 | 离体器官灌注容器 |
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