WO2021016211A1 - Matrice polymère poreuse autocicatrisante pour l'encapsulation de macromolécules actives et procédés - Google Patents

Matrice polymère poreuse autocicatrisante pour l'encapsulation de macromolécules actives et procédés Download PDF

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Publication number
WO2021016211A1
WO2021016211A1 PCT/US2020/042824 US2020042824W WO2021016211A1 WO 2021016211 A1 WO2021016211 A1 WO 2021016211A1 US 2020042824 W US2020042824 W US 2020042824W WO 2021016211 A1 WO2021016211 A1 WO 2021016211A1
Authority
WO
WIPO (PCT)
Prior art keywords
polymer matrix
macromolecule
porous self
healing polymer
healing
Prior art date
Application number
PCT/US2020/042824
Other languages
English (en)
Inventor
Steven P. Schwendeman
Jason Albert
Rae Sung CHANG
George A. GARCIA
Original Assignee
The Regents Of The University Of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of Michigan filed Critical The Regents Of The University Of Michigan
Priority to US17/627,878 priority Critical patent/US20220257769A1/en
Priority to EP20753844.8A priority patent/EP3999025A1/fr
Publication of WO2021016211A1 publication Critical patent/WO2021016211A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne une matrice polymère poreuse autocicatrisante pour l'encapsulation de macromolécules actives et un procédé de fabrication de ladite matrice polymère poreuse autocicatrisante pour un système d'administration de médicament pour une macromolécule.
PCT/US2020/042824 2019-07-19 2020-07-20 Matrice polymère poreuse autocicatrisante pour l'encapsulation de macromolécules actives et procédés WO2021016211A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US17/627,878 US20220257769A1 (en) 2019-07-19 2020-07-20 Porous Self-Healing Polymer Matrix For Encapsulation Of Active Macromolecules And Methods
EP20753844.8A EP3999025A1 (fr) 2019-07-19 2020-07-20 Matrice polymère poreuse autocicatrisante pour l'encapsulation de macromolécules actives et procédés

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962876373P 2019-07-19 2019-07-19
US62/876,373 2019-07-19

Publications (1)

Publication Number Publication Date
WO2021016211A1 true WO2021016211A1 (fr) 2021-01-28

Family

ID=71996067

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2020/042824 WO2021016211A1 (fr) 2019-07-19 2020-07-20 Matrice polymère poreuse autocicatrisante pour l'encapsulation de macromolécules actives et procédés

Country Status (3)

Country Link
US (1) US20220257769A1 (fr)
EP (1) EP3999025A1 (fr)
WO (1) WO2021016211A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999000670A1 (fr) * 1997-06-25 1999-01-07 Innogenetics N.V. Procedes pour l'immobilisation de biomolecules par covalence sur un vecteur a l'aide d'un marqueur d'histidine
US20080131478A1 (en) * 2004-05-14 2008-06-05 The Regents Of The University Of Michigan Methods for Encapsulation of Biomacromolecules in Polymers
WO2011088229A2 (fr) * 2010-01-13 2011-07-21 The Regents Of The University Of Michigan Système de biomatériau auto-réparateur actif
WO2015070172A1 (fr) * 2013-11-08 2015-05-14 The Regents Of The University Of Michigan Encapsulation aqueuse efficace et libération contrôlée d'agents bioactifs

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999000670A1 (fr) * 1997-06-25 1999-01-07 Innogenetics N.V. Procedes pour l'immobilisation de biomolecules par covalence sur un vecteur a l'aide d'un marqueur d'histidine
US20080131478A1 (en) * 2004-05-14 2008-06-05 The Regents Of The University Of Michigan Methods for Encapsulation of Biomacromolecules in Polymers
US8017155B2 (en) 2004-05-14 2011-09-13 The Regents Of The University Of Michigan Methods for encapsulation of biomacromolecules in polymers
WO2011088229A2 (fr) * 2010-01-13 2011-07-21 The Regents Of The University Of Michigan Système de biomatériau auto-réparateur actif
US20120288537A1 (en) 2010-01-13 2012-11-15 The Regents Of The University Of Michigan Active self-healing biomaterial system
WO2015070172A1 (fr) * 2013-11-08 2015-05-14 The Regents Of The University Of Michigan Encapsulation aqueuse efficace et libération contrôlée d'agents bioactifs
US20150164805A1 (en) 2013-11-08 2015-06-18 The Regents Of The University Of Michigan Efficient aqueous encapsulation and controlled release of bioactive agents

Also Published As

Publication number Publication date
EP3999025A1 (fr) 2022-05-25
US20220257769A1 (en) 2022-08-18

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