WO2021012127A1 - Medical ventilation method and device, ventilator, and computer readable storage medium - Google Patents
Medical ventilation method and device, ventilator, and computer readable storage medium Download PDFInfo
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- WO2021012127A1 WO2021012127A1 PCT/CN2019/096912 CN2019096912W WO2021012127A1 WO 2021012127 A1 WO2021012127 A1 WO 2021012127A1 CN 2019096912 W CN2019096912 W CN 2019096912W WO 2021012127 A1 WO2021012127 A1 WO 2021012127A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
Definitions
- the embodiments of the present invention relate to the technical field of medical devices, and in particular, to a medical ventilation method and device, a ventilator, and a computer-readable storage medium.
- High Frequency Ventilation is a ventilation mode that maintains a higher ventilation frequency, lower tidal volume, and lower airway pressure.
- HBV High Frequency Ventilation
- the embodiments of the present invention expect to provide a medical ventilation method and device, a ventilator, and a computer-readable storage medium, which can improve the accuracy of flow measurement.
- the embodiment of the present invention provides a medical ventilation device, the device includes:
- a first branch connected to the first gas input port
- a second branch connected to the second gas input port
- a mixing chamber connected to the first branch and the second branch;
- a high-frequency oscillation generating device connected to the mixing cavity
- a flow sensor for detecting the gas flow velocity in the first branch and the second branch respectively
- a pressure sensor that detects the gas pressure in the first branch and the second branch respectively, or detects the gas pressure in the mixing chamber
- the processor calculates the gas flow rate output by the high-frequency oscillation generating device based on the pressure detected by the pressure sensor and the gas flow rate detected by the flow sensor.
- the flow sensor includes: a first flow sensor and a second flow sensor; the first flow sensor measures the flow rate of the first gas in the first branch; the second flow rate The sensor measures the second gas flow rate in the second branch.
- the pressure sensor includes a first pressure sensor and a second pressure sensor
- the first pressure sensor detects the first pressure in the first branch
- the second pressure sensor detects the second pressure in the second branch
- the processor calculates the high frequency oscillation based on the first pressure detected by the first pressure sensor and the second pressure detected by the second pressure sensor in combination with the first gas flow rate and the second gas flow rate The gas flow rate output by the generator.
- the pressure sensor includes a third pressure sensor that detects the gas pressure in the mixing chamber
- the processor calculates the gas flow rate output by the high-frequency oscillation generating device based on the third pressure detected by the third pressure sensor in combination with the first gas flow rate and the second gas flow rate.
- the medical ventilation device further includes: a pressure generator connected to the high-frequency oscillation generating device.
- the medical ventilation device further includes a fourth pressure sensor
- the fourth pressure sensor is connected to the pressure generator, and measures the fourth pressure output by the pressure generator;
- the processor is based on the pressure of the gas in the first branch and the second branch or the pressure of the gas in the mixing chamber, the fourth pressure detected by the fourth pressure sensor, and the first branch Calculating the flow rate of the gas output by the high-frequency oscillation generator.
- the processor controls the first gas flow rate of the first branch and the second gas flow rate of the second branch based on the calculated gas flow rate output by the high-frequency oscillation generating device. Gas flow rate.
- the first branch is further provided with a first flow controller; the second branch is further provided with a second flow controller.
- the embodiment of the present invention provides a medical ventilation method, which is applied to the medical ventilation device provided in the embodiment of the present invention, and the method includes:
- the pressure sensor detects the gas pressure in the first branch and the second branch respectively, or detects the gas pressure in the mixing chamber, and outputs the pressure;
- a flow sensor detects the gas flow velocity in the first branch and the second branch respectively
- the processor calculates the gas flow rate output by the high-frequency oscillation generating device based on the pressure detected by the pressure sensor and the gas flow rate detected by the flow sensor.
- the flow sensor includes: a first flow sensor and a second flow sensor; the step of detecting the gas flow rate in the first branch and the second branch by the flow sensor respectively includes:
- the first flow sensor detects the flow rate of the first gas in the first branch, and outputs the flow rate of the first gas
- the second flow sensor detects the flow rate of the second gas in the second branch, and outputs the second gas flow rate.
- the pressure sensor includes a first pressure sensor and a second pressure sensor; the pressure sensor detects the gas pressure in the first branch and the second branch respectively, and the step of outputting the pressure includes:
- the first pressure sensor detects the gas pressure in the first branch, and outputs a first pressure
- the second pressure sensor detects the gas pressure in the second branch and outputs a second pressure.
- the step of the processor calculating the gas flow rate output by the high-frequency oscillation generating device based on the pressure detected by the pressure sensor and the gas flow rate detected by the flow sensor includes:
- the processor calculates the gas flow rate output by the high-frequency oscillation generator based on the first pressure, the second pressure, and the first gas flow rate and the second gas flow rate.
- the pressure sensor includes a third pressure sensor that detects the gas pressure in the mixing chamber; the processor calculates the high pressure based on the pressure detected by the pressure sensor and the gas flow rate detected by the flow sensor.
- the steps of frequency oscillation generating equipment output gas flow rate include:
- the processor calculates the gas flow rate output by the high-frequency oscillation generating device based on the third pressure detected by the third pressure sensor in combination with the first gas flow rate and the second gas flow rate.
- the medical ventilation device further includes: a pressure generator connected to the high-frequency oscillation generating device.
- the medical ventilation device further includes a fourth pressure sensor; the processor calculates the gas output by the high-frequency oscillation generator based on the pressure detected by the pressure sensor and the gas flow rate detected by the flow sensor
- the flow rate steps include:
- the fourth pressure sensor is connected to the pressure generator, and measures the fourth pressure output by the pressure generator;
- the processor is based on the pressure of the gas in the first branch and the second branch or the pressure of the gas in the mixing chamber, the fourth pressure detected by the fourth pressure sensor, and the first branch and The flow rate of the gas in the second branch is calculated from the flow rate of the gas output by the high-frequency oscillation generating device.
- the method further includes:
- the processor controls the first gas flow rate of the first branch and the second gas flow rate of the second branch based on the calculated gas flow rate output by the high-frequency oscillation generating device.
- the first branch is further provided with: a first flow controller; the second branch is further provided with: a second flow controller.
- the embodiment of the present invention provides a ventilator, including:
- a medical ventilation device provided by an embodiment of the present invention.
- the embodiment of the present invention provides a computer-readable storage medium that stores executable ventilation instructions, which is used to cause the processor of the medical ventilation device to execute, to implement the medical ventilation method provided by the embodiment of the present invention.
- the medical ventilation method adopts the above-mentioned medical ventilation device.
- the medical ventilation device fully takes into account the pressure fluctuations in the oxygen mixing chamber, so that the gas flow rate output by the high-frequency oscillation generator can be calculated more accurately.
- Fig. 1A is a first structural diagram of an exemplary medical ventilation device provided by an embodiment of the present invention
- Figure 1B is a second structural diagram of an exemplary medical ventilation device provided by an embodiment of the present invention.
- Figure 2 is a third structural diagram of an exemplary medical ventilation device provided by an embodiment of the present invention.
- FIG. 3 is a fourth structural diagram of an exemplary medical ventilation device provided by an embodiment of the present invention.
- FIG. 4 is a fifth structural diagram of an exemplary medical ventilation device provided by an embodiment of the present invention.
- 5A is a sixth structural diagram of an exemplary medical ventilation device provided by an embodiment of the present invention.
- 5B is a seventh structural diagram of an exemplary medical ventilation device provided by an embodiment of the present invention.
- FIG. 6 is a first flowchart of a medical ventilation method provided by an embodiment of the present invention.
- FIG. 7 is a second flowchart of a medical ventilation method provided by an embodiment of the present invention.
- Figure 8 is a third flowchart of a medical ventilation method provided by an embodiment of the present invention.
- Fig. 9 is a fourth flowchart of a medical ventilation method provided by an embodiment of the present invention.
- the embodiment of the present invention provides a medical ventilation method, which is applied to a medical ventilation device. It should be noted that, in the embodiment of the present invention, the ventilation control method may be executed by a medical ventilation device or a ventilation device.
- Fig. 1 is a schematic structural diagram of a medical ventilation device provided by an embodiment of the present invention.
- the medical ventilation device 1 includes: a first gas input port 10 for receiving a first gas;
- the first branch 12 connected to the first gas input port 10;
- the second branch 13 connected to the second gas input port 11;
- the mixing chamber 14 connected to the first branch 12 and the second branch 13;
- a high-frequency oscillation generating device 15 connected to the mixing cavity 14;
- a flow sensor 16 for detecting the gas flow velocity in the first branch 12 and the second branch 13 respectively;
- a pressure sensor 17 that detects the gas pressure in the first branch 12 and the second branch 13 respectively, or detects the gas pressure in the mixing chamber 14;
- the processor 18 calculates the gas flow rate output by the high-frequency oscillation generating device 15 based on the pressure detected by the pressure sensor 17 and the gas flow rate detected by the flow sensor 16.
- the pressure sensors 17 arranged in the first branch 12 and the second branch 13, or the pressure sensors 17 arranged near the mixing chamber 14 or elsewhere to detect the gas pressure in the mixing chamber 14, can measure
- the gas pressure of the first gas and the second gas before passing through the high-frequency oscillation generating device 15 is based on the pressure detected by the pressure sensor 17 and the gas flow rate detected by the flow sensor 16 provided in the first branch 12 and the second branch 13,
- this medical ventilation method takes into account the influence of the pressure fluctuation generated in the oxygen mixing chamber on the gas flow rate, so that the gas flow rate output by the high-frequency oscillation generating device 15 can pass more accurately. Calculated.
- the processor can be implemented by software, hardware, firmware, or a combination thereof, and can use circuits, single or multiple application specific integrated circuits (ASIC), single or multiple general integrated circuits, single or multiple micro-processing A device, a single or multiple programmable logic devices, or a combination of the foregoing circuits or devices, or other suitable circuits or devices, so that the processor can execute the corresponding steps of the medical ventilation method.
- the high-frequency oscillation generating device 15 may be: a high-frequency valve, a vibration unit, a diaphragm or an on-off valve and other devices for generating high-frequency oscillation, which is not limited in the embodiment of the present invention.
- the first gas and the second gas are air and oxygen respectively.
- the first gas input port 10 is the oxygen input port
- the second gas input port 11 is the air input port
- the first gas input port 10 is an air input port
- the second gas input port 11 is an oxygen input port.
- the first gas and the second gas when input to the medical ventilation device, they can be input according to a fixed ratio.
- the fixed ratio is determined by the requirements of the actual ventilation process and is not limited by the embodiment of the present invention.
- the first gas input port 10 is connected to the first branch 12, and the second gas input port 11 is connected to the first branch 12.
- the first branch 12 and the first branch 12 are ventilating branches
- the first branch 12 is a passage for transmitting the first gas
- the second branch 13 is a passage for transmitting the second gas.
- the first branch 12 and the second branch 13 are both provided with a flow sensor 16, wherein the flow sensor 16 provided on the first branch 12 may be the first flow sensor 160; The flow sensor 16 provided on the road 13 may be the second flow sensor 161.
- the first flow sensor 160 measures the first gas flow rate in the first branch 12; the second flow sensor 161 measures the second gas flow rate in the second branch 13.
- the first branch 12 and the second branch 13 are also provided with flow controllers, the first branch 12 is provided with a first flow controller 110, and the first branch 12 is provided with a first flow controller 110.
- a second flow controller 111 is provided on the second branch 13.
- the flow controller may include an air proportional valve and an oxygen proportional valve.
- the branch used for oxygen transmission uses an oxygen proportional valve, and the branch used for air transmission uses an air proportional valve.
- the processor 18 can control the input flow rate by controlling the opening and closing of the proportional valve.
- the flow controller can also be implemented with a high-frequency valve, a vibration unit, a diaphragm, or an on-off valve, which is not limited in the embodiment of the present invention.
- the processor 18 may control the first branch 12 through the first flow controller 110 and the second flow controller 111 based on the calculated gas flow rate output by the high-frequency oscillation generating device 15
- the first gas flow rate and the second gas flow rate output by the second branch 13 are used to control the output gas flow rate of the high-frequency oscillation generating device 15 to achieve the preset target.
- the processor 18 can control the first flow controller 110 and the second flow controller 111 based on the gas flow rate output by the high frequency oscillation generating device 15 after obtaining the gas flow rate output by the high frequency oscillation generating device 15, In order to realize the control of the first gas flow rate output by the first branch 11 and the second gas flow rate output by the second branch 13.
- the flow sensor 16 is connected to a flow controller, and the flow controller is arranged between the gas input port and the mixing chamber 14, and the flow sensor 16 can be arranged on the corresponding flow controller and gas input.
- the ports can also be arranged between the flow controller and the mixing chamber 14, which is not limited in the embodiment of the present invention.
- the first flow sensor 160 is connected to the oxygen proportional valve 110, and the second flow sensor 161 is connected to the air proportional valve 111.
- the processor 18 is connected to the pressure sensor 17 and the flow sensor 16, and the flow controller. In order to simplify the figure, the processor is no longer shown in the illustrations in the following embodiments.
- the pressure sensor 17 includes a first pressure sensor 170 and a second pressure sensor 171; the first pressure sensor 170 detects the first pressure in the first branch 12; The pressure sensor 171 detects the second pressure in the second branch 13.
- first pressure sensor 170 and the second pressure sensor 171 on the first branch 12 and the second branch 13 are not limited in the embodiment of the present invention, and only need to be provided at the gas input port and the mixing chamber 14.
- Figure 2 is only an exemplary setting.
- the processor 18 may combine the first gas flow rate and the second gas flow rate, and the preset pressure and the second pressure based on the first pressure detected by the first pressure sensor 170 and the second pressure detected by the second pressure sensor 171. The relationship between the gas flow rate and the gas flow rate output by the high-frequency oscillation generator 15 is calculated.
- the gas flow rate output by the high-frequency oscillation generator 15 can be calculated by the following formula (2), which is specifically:
- Q1 is the first gas flow rate
- Q2 is the second gas flow rate
- Q3 is the total gas flow rate output by the high-frequency oscillation generator 15
- PS1 is the first pressure
- PS2 is the second pressure
- P is the atmospheric pressure (1.013X10 ⁇ 5pa)
- a1 and a2 are correction coefficients.
- the correction coefficient is a coefficient for correcting the relationship between the preset pressure and the gas flow rate, which can be obtained through experiments or actual training.
- the method for obtaining the correction coefficient is not limited in the embodiment of the present invention.
- the gas flow rate and the gas flow rate are equivalent concepts.
- the medical ventilation device calculates the gas flow rate output by the high-frequency oscillation generating device 15, it can be calculated by the pressure of the first branch 12 and the second branch 13, or by the pressure in the mixing chamber 14. In the calculation, no matter which method is adopted, the gas pressure fluctuation before the high-frequency oscillation generating device 15 is considered.
- the pressure sensor 17 includes a third pressure sensor 172 that detects the gas pressure in the mixing chamber 14.
- the processor 18 calculates the gas flow rate output by the high-frequency oscillation generating device 15 based on the third pressure detected by the third pressure sensor 172 in combination with the first gas flow rate and the second gas flow rate.
- the third pressure sensor 172 may be arranged in the mixing chamber 14 or after the first flow controller 110 and the second flow controller 111 or before the high-frequency oscillation generating device 15.
- the processor 18 in the medical ventilation device 1 can obtain the high frequency based on the third pressure detected by the third pressure sensor 172, combining the first gas flow rate and the second gas flow rate, and the relationship between the preset pressure and the gas flow rate.
- Q1 is the first gas flow
- Q2 is the second gas flow
- Q3 is the total gas flow output by the high-frequency oscillation generator 15
- PSO is the third pressure
- P is the atmospheric pressure (1.013X10 ⁇ 5pa)
- a is the correction coefficient.
- the medical ventilation device 1 further includes: a pressure generator 19 connected to a high-frequency oscillation generating device 15.
- the first gas output by the first branch 12 and the second gas output by the second branch 13 are mixed in the mixing chamber 14, and finally pass through the high frequency.
- the frequency oscillation generating device 15 generates high frequency oscillation gas, which is output to the patient via the pressure generator 19.
- the first gas is high-pressure oxygen and the second gas is high-pressure air
- the first flow controller 110 uses an oxygen proportional valve
- the second flow controller 111 uses an air proportional valve
- the high-frequency oscillation generator 15 is a high-frequency
- the first flow sensor 160 is an oxygen flow sensor
- the second flow sensor 161 is a control gas flow sensor.
- the working process of the gas circuit can be: high-pressure oxygen passes through the oxygen flow sensor and the oxygen proportional valve, and enters the mixing chamber 14 through the control flow of the oxygen proportional valve, and the high-pressure air passes through the air flow sensor and the air proportional valve.
- the flow rate controlled by the air proportional valve enters the mixing chamber 14, high-pressure air and high-pressure oxygen are mixed in the mixing chamber 14, and then passed through the high-frequency proportional valve, transmitted to the pressure generator 19, and finally output to the patient end, the excess gas It is discharged from the atmospheric end of the pressure generator 19.
- one end of the pressure generator 19 is connected to the high-frequency oscillation generating device 15, one end is connected to the patient interface, and the other end is connected to the atmosphere.
- the medical ventilation device 1 further includes a fourth pressure sensor 173; the fourth pressure sensor 173 is connected to the pressure generator 19 to measure the fourth pressure output by the pressure generator 19.
- the processor 18 is based on the pressure of the gas in the first branch 12 and the second branch 13 or the pressure of the gas in the mixing chamber 14, the fourth pressure detected by the fourth pressure sensor 173, and the first branch.
- the flow rate of the gas in the circuit 12 and the second branch 13 is calculated from the gas flow rate output by the high-frequency oscillation generator 15.
- the fourth pressure sensor 173 may be arranged between the high-frequency oscillation generator 15 and the pressure generator 19, or may be arranged on the pressure generator 19 for real-time detection, which is not limited in the embodiment of the present invention.
- the detected pressure at the end of the pressure generator 19 can be used instead of the atmospheric pressure to calculate the gas flow rate output by the high-frequency oscillation generator 15 .
- the processor 18 in the medical ventilation device 1 may be based on the first pressure, the second pressure, and the fourth pressure, combining the first gas flow rate and the second gas flow rate, and the preset pressure and gas flow rate.
- the gas flow rate output by the high-frequency oscillation generator 15 is obtained.
- the gas flow rate of the high-frequency oscillation generating device 15 can be calculated by formula (4), as follows:
- PS3 is the fourth pressure.
- the medical ventilation device can measure the pressure of the first branch 12 and the second branch 13, and based on the above pressure, and the detected gas flow rate in the first branch 12 and the second branch 13, based on The relationship between the pressure change and the inverse ratio of the volume length can be used to calculate the gas flow rate output by the high-frequency oscillation generator 15, taking into account the pressure fluctuations that occur when the first branch 12 and the second branch 13 reach the mixing chamber.
- the gas flow rate output by the high-frequency oscillation generating device 15 can be accurately calculated, thereby improving the measurement accuracy of the gas flow rate.
- the processor 18 in the medical ventilation device 1 may combine the first gas flow rate and the second gas flow rate, and the relationship between the preset pressure and the gas flow rate based on the third pressure and the fourth pressure, Calculate the gas flow rate output by the high-frequency oscillation generator 15.
- the gas flow rate output by the high-frequency oscillation generating device 15 can be calculated by formula (5), as follows:
- the medical ventilation device can measure the third pressure of the mixing chamber 14 based on the third pressure, and the detected gas flow rate in the first branch 12 and the second branch 13, based on the pressure change and volume length.
- the gas flow rate output by the high-frequency oscillation generating device 15 can be calculated, and the pressure fluctuations generated by the oxygen mixing chamber are fully considered, so that the gas flow rate output by the high-frequency oscillation generating device 15 can be accurately calculated, thereby improving Measuring accuracy of gas flow rate.
- FIG. 6 is a schematic flowchart of a medical ventilation method applied to a medical ventilation device according to an embodiment of the present invention. As shown in Figure 6, the medical ventilation method mainly includes the following steps:
- the pressure sensor detects the gas pressure in the first branch and the second branch respectively, or detects the gas pressure in the mixing chamber, and outputs the pressure.
- the flow sensor detects the gas flow rate in the first branch and the second branch respectively.
- the processor calculates the gas flow rate output by the high-frequency oscillation generating device based on the pressure detected by the pressure sensor and the gas flow rate detected by the flow sensor.
- the medical ventilation method provided in the embodiment of the present invention is applied in the high-frequency ventilation mode, and can also be applied in the CPAP and BiLEVEL ventilation modes, which is not limited by the embodiment of the present invention.
- the following takes the high-frequency ventilation mode as an example.
- the medical ventilation device is provided with a second gas input port that receives the second gas; a first branch connected to the first gas input port; a second branch connected to the second gas input port;
- the mixing chamber connected to the first branch and the second branch; the high-frequency oscillation generator connected to the mixing chamber; the flow sensor that detects the gas flow velocity in the first branch and the second branch respectively; the first branch is detected separately And the gas pressure in the second branch, or a pressure sensor that detects the gas pressure in the mixing chamber; and, the processor.
- the first gas and the second gas are air and oxygen respectively.
- the first gas input port 10 is the oxygen input port
- the second gas input port is the air input port
- the first gas input port is an air input port
- the second gas input port is an oxygen input port.
- the first gas and the second gas when input to the medical ventilation device, they can be input according to a fixed ratio.
- the fixed ratio is determined by the requirements of the actual ventilation process and is not limited by the embodiment of the present invention.
- the first gas input port is connected to the first branch
- the second gas input port is connected to the first branch.
- the first branch and the first branch are ventilation branches
- the first branch is a passage for transmitting the first gas
- the second branch is a passage for transmitting the second gas.
- the high-frequency oscillation generating device may be: a high-frequency valve, a vibration unit, a diaphragm or an on-off valve and other devices used to generate high-frequency oscillation, which is not limited in the embodiment of the present invention.
- the pressure sensor detects the gas pressure in the first branch and the second branch respectively, or detects the gas pressure in the mixing chamber, and outputs the pressure;
- the flow sensor detects the gas pressure in the first branch and the second branch respectively Gas flow rate.
- the processor can calculate the gas flow rate output by the high-frequency oscillation generator based on the pressure detected by the pressure sensor and the gas flow rate detected by the flow sensor.
- the pressure sensors arranged in the first branch and the second branch can measure the pressure of the first gas and the second gas
- the gas flow rate output by the high-frequency oscillation generating device is calculated based on the pressure detected by the pressure sensor and the gas flow rate detected by the flow sensors arranged in the first branch and the second branch.
- the medical ventilation method takes into account the influence of pressure fluctuations generated in the oxygen mixing chamber on the gas flow rate, so that the gas flow rate output by the high-frequency oscillation generator can be more accurately calculated.
- the flow sensor includes: a first flow sensor and a second flow sensor; the pressure sensor includes a first pressure sensor and a second pressure sensor; thus, as shown in FIG. 7, the embodiment of the present invention also provides A method of medical ventilation including:
- the first pressure sensor detects the gas pressure in the first branch, and outputs the first pressure.
- the second pressure sensor detects the gas pressure in the second branch, and outputs the second pressure.
- the first flow sensor detects the flow rate of the first gas in the first branch, and outputs the first gas flow rate.
- the second flow sensor detects the flow rate of the second gas in the second branch, and outputs the second gas flow rate.
- the processor calculates the gas flow rate output by the high-frequency oscillation generator based on the first pressure, the second pressure, and the first gas flow rate and the second gas flow rate.
- the location of the first pressure sensor and the second pressure sensor on the first branch and the second branch is not limited in the embodiment of the present invention, and only needs to be between other gas input ports and the mixing chamber.
- flow sensors are provided on both the first branch and the second branch, wherein the flow sensor provided on the first branch may be the first flow sensor; the flow sensor provided on the second branch may be the first 2.
- Flow sensor The first flow sensor measures the first gas flow rate in the first branch; the second flow sensor measures the second gas flow rate in the second branch.
- the processor in the medical ventilation device can calculate the high-frequency oscillation generating equipment based on the first pressure and the second pressure, combining the first gas flow rate and the second gas flow rate, and the relationship between the preset pressure and the gas flow rate.
- the output gas flow rate can be calculated based on the first pressure and the second pressure, combining the first gas flow rate and the second gas flow rate, and the relationship between the preset pressure and the gas flow rate.
- p is the atmospheric pressure
- v is the gas volume
- n is the amount of substance
- R is the ideal gas constant
- T is the temperature.
- the gas flow rate output by the high-frequency oscillation generating device can be calculated by the following formula (2), specifically:
- Q1 is the first gas flow
- Q2 is the second gas flow
- Q3 is the total gas flow output by the high-frequency oscillation generator
- PS1 is the first pressure
- PS2 is the second pressure
- P is the atmospheric pressure (1.013X10 ⁇ 5pa )
- a1 and a2 are correction coefficients.
- the correction coefficient is a coefficient for correcting the relationship between the preset pressure and the gas flow rate. It can be obtained through experiments or actual training.
- the method for obtaining the correction coefficient is not limited in the embodiment of the present invention.
- the gas flow rate and the gas flow rate are equivalent concepts.
- this method fully takes into account the pressure fluctuations that occur when the first branch and the second branch reach the mixed oxygen chamber, so that the gas flow rate output by the high-frequency oscillation generator can be accurately calculated, thereby improving Measuring accuracy of gas flow rate.
- the flow sensor includes: a first flow sensor and a second flow sensor; the pressure sensor includes a third pressure sensor that detects the gas pressure in the mixing chamber; thus, as shown in FIG. 8, the embodiment of the present invention
- a medical ventilation method is also provided, including:
- the third pressure sensor detects the gas pressure in the mixing chamber and outputs a third pressure.
- the first flow sensor detects the flow rate of the first gas in the first branch, and outputs the first gas flow rate.
- the second flow sensor detects the flow rate of the second gas in the second branch, and outputs the second gas flow rate.
- S304 Based on the third pressure detected by the third pressure sensor, the processor calculates the gas flow rate output by the high-frequency oscillation generator in combination with the first gas flow rate and the second gas flow rate.
- the third pressure sensor can be arranged between the mixing cavity and the high-frequency oscillation generating device.
- the processor in the medical ventilation device can obtain a high-frequency oscillation generating device based on the third pressure detected by the third pressure sensor, combining the first gas flow rate and the second gas flow rate, and the relationship between the preset pressure and the gas flow rate.
- the output gas flow rate Specifically, the gas flow rate output by the high-frequency oscillation generator can be calculated by the following formula (3), as follows:
- Q1 is the first gas flow
- Q2 is the second gas flow
- Q3 is the total gas flow output by the high-frequency oscillation generator
- PS0 is the third pressure
- P is the atmospheric pressure (1.013X10 ⁇ 5pa)
- a is the correction coefficient .
- the medical ventilation device can measure the third pressure of the mixing chamber based on the third pressure, and the detected gas flow rate in the first branch and the second branch, based on the inverse relationship between the pressure change and the volume length ,
- the gas flow rate output by the high-frequency oscillation generator can be calculated, taking into account the pressure fluctuations in the mixed oxygen chamber, so that the gas flow rate output by the high-frequency oscillation generator can be accurately calculated, thereby improving the measurement of the measured gas flow rate Accuracy.
- the medical ventilation device further includes: a pressure generator connected to the high-frequency oscillation generating device.
- the medical ventilation device further includes a fourth pressure sensor; the fourth pressure sensor is connected to the pressure generator and measures the fourth pressure output by the pressure generator; as shown in FIG. 9, an embodiment of the present invention also provides a medical ventilation method, including :
- the first flow sensor detects the flow rate of the first gas in the first branch, and outputs the first gas flow rate.
- the second flow sensor detects the flow rate of the second gas in the second branch, and outputs the second gas flow rate.
- the fourth pressure sensor measures the pressure generator and outputs the fourth pressure.
- the first pressure sensor detects the gas pressure in the first branch, and outputs the first pressure.
- the second pressure sensor detects the gas pressure in the second branch and outputs the second pressure.
- the processor is based on the first pressure and the second pressure of the gas in the first branch and the second branch, the fourth pressure detected by the fourth pressure sensor, and the flow rate of the gas in the first branch and the second branch. , Calculate the gas flow rate output by the high-frequency oscillation generator.
- the third pressure sensor detects the gas pressure in the mixing chamber, and outputs the third pressure.
- the processor calculates the gas flow rate output by the high-frequency oscillation generating device based on the third pressure and the fourth pressure detected by the fourth pressure sensor, and the flow rate of the gas in the first branch and the second branch.
- the device in the high-frequency ventilation mode, during high-frequency air supply, the first gas output by the first branch and the second gas output by the second branch are mixed in the mixing chamber, and finally generated by high-frequency oscillation
- the device generates high-frequency oscillating gas, which is output to the patient via a pressure generator.
- the first gas is high-pressure oxygen
- the second gas is high-pressure air
- the first flow controller uses an oxygen proportional valve
- the second flow controller uses an air proportional valve
- the high-frequency oscillation generator is a high-frequency proportional valve.
- the first flow sensor is an oxygen flow sensor
- the second flow sensor is a control gas flow sensor.
- the working process of the gas circuit can be: high-pressure oxygen passes through the oxygen flow sensor and the oxygen proportional valve, and enters the mixing chamber through the control flow of the oxygen proportional valve, and high-pressure air passes through the air flow sensor and the air proportional valve.
- the control flow of the air proportional valve enters the mixing chamber, and the high-pressure air and high-pressure oxygen are mixed in the mixing chamber, and then passed through the high-frequency proportional valve, transmitted to the pressure generator, and finally output to the patient end.
- the excess gas is generated from the pressure
- the air side of the device is discharged.
- one end of the pressure generator is connected to the high-frequency oscillation generator, one end is connected to the patient interface, and the other end is connected to the atmosphere.
- the fourth pressure sensor may be disposed between the high-frequency oscillation generating device and the pressure generator, or may be disposed on the pressure generator for real-time detection, which is not limited in the embodiment of the present invention.
- the pressure detected at the end of the pressure generator can be used instead of the atmospheric pressure to calculate the gas flow output by the high-frequency oscillation generating device.
- the processor in the medical ventilation device can obtain high frequency based on the first pressure, second pressure, and fourth pressure, combining the first gas flow rate and the second gas flow rate, and the relationship between the preset pressure and the gas flow rate.
- the flow rate of gas output by the oscillating device can be calculated by formula (4), as follows:
- PS3 is the fourth pressure.
- the medical ventilation device can measure the pressure of the first branch and the second branch based on the above pressure, and the detected gas flow rate in the first branch and the second branch, based on the pressure change and volume
- the relationship between the length and the inverse ratio can calculate the gas flow rate output by the high-frequency oscillation generator, taking into account the pressure fluctuations generated from the first branch and the second branch to the mixed oxygen chamber, which makes the high-frequency oscillation generator output
- the gas flow rate can be accurately calculated, thereby improving the measurement accuracy of measuring the gas flow rate.
- the processor in the medical ventilation device can calculate the output of the high-frequency oscillation generator based on the third pressure and the fourth pressure, combining the first gas flow rate and the second gas flow rate, and the relationship between the preset pressure and the gas flow rate The gas flow rate.
- the gas flow rate output by the high-frequency oscillation generator can be calculated by formula (5), as follows:
- the medical ventilation device can measure the third pressure of the mixing chamber based on the third pressure, and the detected gas flow rate in the first branch and the second branch, based on the inverse relationship between the pressure change and the volume length ,
- the gas flow rate output by the high-frequency oscillation generator can be calculated, taking into account the pressure fluctuations in the mixed oxygen chamber, so that the gas flow rate output by the high-frequency oscillation generator can be accurately calculated, thereby improving the measurement of the measured gas flow rate Accuracy.
- S401-406 is a medical ventilation method that uses a fourth pressure sensor to measure the gas flow rate output by a high-frequency oscillation generating device
- S401-403 and S407-S408 are another method that uses a fourth pressure sensor to measure high frequency.
- a medical ventilation method that oscillates the gas flow rate output by the device. The specific method used to measure the gas flow rate output by the high-frequency oscillation generating device is determined by the setting mode of the actual pressure sensor, which is not limited in the embodiment of the present invention.
- the first branch is further provided with: a first flow controller; the second branch is further provided with: a second flow controller.
- the processor controls the first gas flow rate and the second gas flow rate of the first branch based on the calculated gas flow rate output by the high-frequency oscillation generating device. The second gas flow rate output by the branch.
- flow sensors are provided on both the first branch and the second branch, wherein the flow sensor provided on the first branch may be the first flow sensor; the flow sensor provided on the second branch may be the first 2.
- Flow sensor The first flow sensor measures the first gas flow rate in the first branch; the second flow sensor measures the second gas flow rate in the second branch.
- the first branch and the second branch are further provided with a flow controller, the first branch is provided with a first flow controller, and the second branch is provided with a second flow controller.
- the flow controller may include an air proportional valve and an oxygen proportional valve.
- the branch used for oxygen transmission uses an oxygen proportional valve, and the branch used for air transmission uses an air proportional valve.
- the processor can control the input flow rate by controlling the opening and closing of the proportional valve.
- the flow controller can also be implemented with a high-frequency valve, a vibration unit, a diaphragm, or an on-off valve, which is not limited in the embodiment of the present invention.
- the processor may control the first gas flow rate of the first branch and the second gas flow rate of the second branch based on the calculated gas flow rate output by the high-frequency oscillation generating device.
- the processor obtains the gas flow rate output by the high-frequency oscillation generating device, based on the gas flow rate output by the high-frequency oscillation generating device, it can control the first flow controller and the second flow controller in turn to achieve the first Control of the first gas flow rate output by the branch and the second gas flow rate output by the second branch.
- the flow sensor is connected to the flow controller, the flow controller is arranged between the gas input port and the mixing chamber, and the flow sensor can be arranged between the corresponding flow controller and the gas input port , It can also be set in the flow controller and the mixing chamber, which is not limited in the embodiment of the present invention.
- the first flow sensor is connected to the oxygen proportional valve
- the second flow sensor is connected to the air proportional valve
- the medical ventilation device can be based on other pressures in the first branch or the second branch to characterize the pressure fluctuations on the mixing chamber side of the high-frequency oscillation generating device before the oscillation, or directly through measurement
- the gas pressure of the mixing chamber is used to measure the flow rate of the high-frequency gas oscillated by the high-frequency oscillation generator, thereby improving the accuracy of the measurement.
- the first branch and the second branch can be controlled based on the measured flow rate of the high-frequency gas.
- the switch of the flow controller of the branch makes the ratio or flow of the first gas and the second gas change to meet the demand of high-frequency ventilation.
- the embodiment of the present invention provides a ventilator including: the medical ventilation device with the above structure.
- the embodiment of the present invention also provides a computer-readable storage medium that stores executable ventilation instructions for causing the processor of the medical ventilation device to execute the ventilation method provided in the embodiments of the present invention.
- each unit may exist alone physically, or two or more units may be integrated into one unit.
- the above-mentioned integrated unit can be realized in the form of hardware or software function module.
- the integrated unit is implemented in the form of a software function module and is not sold or used as an independent product, it can be stored in a computer readable storage medium.
- the technical solution of this embodiment is essentially or It is said that the part that contributes to the existing technology or all or part of the technical solution can be embodied in the form of a software product.
- the computer software product is stored in a storage medium and includes several instructions to enable a computer device (which can A personal computer, server, or network device, etc.) or a processor (processor) executes all or part of the steps of the method described in this embodiment.
- the aforementioned storage media include: magnetic random access memory (FRAM, ferromagnetic random access memory), read-only memory (ROM, Read Only Memory), programmable read-only memory (PROM, Programmable Read-Only Memory), erasable Programmable Read-Only Memory (EPROM, Erasable Programmable Read-Only Memory), Electrically Erasable Programmable Read-Only Memory (EEPROM, Electrically Erasable Programmable Read-Only Memory), Flash Memory, Magnetic Surface Memory, Optical Disk
- FRAM magnetic random access memory
- ROM read-only memory
- PROM programmable Read-Only Memory
- EPROM Erasable Programmable Read-Only Memory
- EEPROM Electrically Erasable Programmable Read-Only Memory
- Flash Memory Magnetic Surface Memory
- Optical Disk Various media that can store program codes, such as CD-ROM (Compact Disc Read-Only Memory), etc., are not limited in the embodiments of the present disclosure.
- the embodiments of the present invention provide a medical ventilation method and device, a ventilator, and a computer-readable storage medium.
- the medical ventilation device can be installed in the first branch and the second branch.
- the pressure sensor obtain the pressure of the first gas and the second gas, or obtain the pressure of the mixed gas of the first gas and the second gas in the mixing chamber in the pressure sensor set near the mixing chamber, and can also detect
- the gas flow rate in the first branch and the second branch is calculated based on the relationship between the pressure change and the inverse ratio of the volume length to the gas flow rate output by the high-frequency oscillation generator.
- This processing fully takes into account the pressure fluctuations in the oxygen mixing chamber , So that the gas flow rate output by the high-frequency oscillation generator can be calculated more accurately, and the measurement accuracy of measuring the gas flow rate is improved.
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Abstract
Description
Claims (19)
- 一种医用通气装置,所述装置包括:A medical ventilation device, the device comprising:接收第一气体的第一气体输入口;A first gas input port for receiving the first gas;接收第二气体的第二气体输入口;A second gas input port for receiving the second gas;与所述第一气体输入口连接的第一支路;A first branch connected to the first gas input port;与所述第二气体输入口连接的第二支路;A second branch connected to the second gas input port;与所述第一支路和所述第二支路连接的混合腔;A mixing chamber connected to the first branch and the second branch;与所述混合腔连接的高频震荡发生设备;A high-frequency oscillation generating device connected to the mixing cavity;分别检测所述第一支路和所述第二支路中气体流速的流量传感器;A flow sensor for detecting the gas flow velocity in the first branch and the second branch respectively;分别检测所述第一支路和所述第二支路中气体压力,或者检测所述混合腔中气体压力的压力传感器;以及,A pressure sensor that detects the gas pressure in the first branch and the second branch respectively, or detects the gas pressure in the mixing chamber; and,处理器,处理器基于所述压力传感器检测的压力和所述流量传感器检测的气体流速,计算所述高频震荡发生设备输出的气体流速。The processor calculates the gas flow rate output by the high-frequency oscillation generating device based on the pressure detected by the pressure sensor and the gas flow rate detected by the flow sensor.
- 根据权利要求1所述的装置,其中,The device of claim 1, wherein:流量传感器包括:第一流量传感器和第二流量传感器;所述第一流量传感器测量所述第一支路中的所述第一气体流速;所述第二流量传感器测量所述第二支路中的所述第二气体流速。The flow sensor includes: a first flow sensor and a second flow sensor; the first flow sensor measures the flow rate of the first gas in the first branch; the second flow sensor measures the flow in the second branch The second gas flow rate.
- 根据权利要求2所述的装置,其中,所述压力传感器包括第一压力传感器和第二压力传感器;The device according to claim 2, wherein the pressure sensor comprises a first pressure sensor and a second pressure sensor;所述第一压力传感器检测所述第一支路中的第一压力;The first pressure sensor detects the first pressure in the first branch;所述第二压力传感器检测所述第二支路中的第二压力;The second pressure sensor detects the second pressure in the second branch;所述处理器基于所述第一压力传感器检测的第一压力和所述第二压力传感器检测的第二压力,结合所述第一气体流速和所述第二气体流速,计算所述高频震荡发生设备输出的气体流速。The processor calculates the high frequency oscillation based on the first pressure detected by the first pressure sensor and the second pressure detected by the second pressure sensor in combination with the first gas flow rate and the second gas flow rate The gas flow rate output by the generator.
- 根据权利要求2所述的装置,其中,所述压力传感器包括检测所述 混合腔中气体压力的第三压力传感器;The device according to claim 2, wherein the pressure sensor comprises a third pressure sensor that detects the pressure of the gas in the mixing chamber;所述处理器基于所述第三压力传感器检测的第三压力,结合所述第一气体流速和所述第二气体流速,计算所述高频震荡发生设备输出的气体流速。The processor calculates the gas flow rate output by the high-frequency oscillation generating device based on the third pressure detected by the third pressure sensor in combination with the first gas flow rate and the second gas flow rate.
- 根据权利要求1所述的装置,其中,医用通气装置还包括:与所述高频震荡发生设备连接的压力发生器。The device according to claim 1, wherein the medical ventilation device further comprises: a pressure generator connected to the high-frequency oscillation generating device.
- 根据权利要求5所述的装置,其中,医用通气装置还包括第四压力传感器;The device according to claim 5, wherein the medical ventilation device further comprises a fourth pressure sensor;所述第四压力传感器与所述压力发生器连接,测量所述压力发生器输出的第四压力;The fourth pressure sensor is connected to the pressure generator, and measures the fourth pressure output by the pressure generator;所述处理器基于所述第一支路和第二支路中气体的压力或所述混合腔中气体的压力,所述第四压力传感器检测的所述第四压力,以及所述第一支路和第二支路中气体的流速,计算所述高频震荡发生设备输出的气体流速。The processor is based on the pressure of the gas in the first branch and the second branch or the pressure of the gas in the mixing chamber, the fourth pressure detected by the fourth pressure sensor, and the first branch Calculating the flow rate of the gas output by the high-frequency oscillation generator.
- 根据权利要求1至6任一项所述的装置,其中,The device according to any one of claims 1 to 6, wherein:所述处理器基于计算得到的所述高频震荡发生设备输出的气体流速,控制所述第一支路输出的第一气体流速和所述第二支路输出的第二气体流速。The processor controls the first gas flow rate output by the first branch and the second gas flow rate output by the second branch based on the calculated gas flow rate output by the high-frequency oscillation generating device.
- 根据权利要求1至7任一项所述的装置,其中,The device according to any one of claims 1 to 7, wherein:所述第一支路还设有:第一流量控制器;所述第二支路还设有:第二流量控制器。The first branch is further provided with: a first flow controller; the second branch is further provided with: a second flow controller.
- 一种医用通气方法,应用于如权利要求1至8任一项所述的医用通气装置中,所述方法包括:A medical ventilation method applied to the medical ventilation device according to any one of claims 1 to 8, the method comprising:压力传感器分别检测第一支路和第二支路中气体压力,或者检测混合腔中气体压力,输出压力;The pressure sensor detects the gas pressure in the first branch and the second branch respectively, or detects the gas pressure in the mixing chamber, and outputs the pressure;流量传感器分别检测所述第一支路和所述第二支路中气体流速;A flow sensor detects the gas flow velocity in the first branch and the second branch respectively;处理器基于所述压力传感器检测的压力和所述流量传感器检测的气体流速,计算所述高频震荡发生设备输出的气体流速。The processor calculates the gas flow rate output by the high-frequency oscillation generating device based on the pressure detected by the pressure sensor and the gas flow rate detected by the flow sensor.
- 根据权利要求9所述的方法,其中,所述流量传感器包括:第一流量传感器和第二流量传感器;所述流量传感器分别检测所述第一支路和所述第二支路中气体流速的步骤包括:The method according to claim 9, wherein the flow sensor comprises: a first flow sensor and a second flow sensor; the flow sensor detects the flow rate of the gas in the first branch and the second branch respectively The steps include:所述第一流量传感器检测第一支路的第一气体的流速,输出第一气体流速;The first flow sensor detects the flow rate of the first gas in the first branch, and outputs the flow rate of the first gas;所述第二流量传感器检测第二支路的第二气体的流速,输出第二气体流速。The second flow sensor detects the flow rate of the second gas in the second branch, and outputs the second gas flow rate.
- 根据权利要求10所述的方法,其中,所述压力传感器包括第一压力传感器和第二压力传感器;所述压力传感器分别检测第一支路和第二支路中气体压力,输出压力的步骤包括:The method according to claim 10, wherein the pressure sensor comprises a first pressure sensor and a second pressure sensor; the pressure sensor detects the gas pressure in the first branch and the second branch respectively, and the step of outputting the pressure comprises :所述第一压力传感器检测所述第一支路中的气体压力,输出第一压力;The first pressure sensor detects the gas pressure in the first branch, and outputs a first pressure;所述第二压力传感器检测所述第二支路中的气体压力,输出第二压力。The second pressure sensor detects the gas pressure in the second branch and outputs a second pressure.
- 根据权利要求11所述的方法,其中,所述处理器基于所述压力传感器检测的压力和所述流量传感器检测的气体流速,计算所述高频震荡发生设备输出的气体流速的步骤包括:The method according to claim 11, wherein the step of the processor calculating the gas flow rate output by the high frequency oscillation generating device based on the pressure detected by the pressure sensor and the gas flow rate detected by the flow sensor comprises:所述处理器基于所述第一压力,所述第二压力,结合所述第一气体流速和所述第二气体流速,计算所述高频震荡发生设备输出的气体流速。The processor calculates the gas flow rate output by the high-frequency oscillation generator based on the first pressure, the second pressure, and the first gas flow rate and the second gas flow rate.
- 根据权利要求10所述的方法,其中,所述压力传感器包括检测所述混合腔中气体压力的第三压力传感器;所述处理器基于所述压力传感器检测的压力和所述流量传感器检测的气体流速,计算所述高频震荡发生设备输出的气体流速的步骤包括:The method of claim 10, wherein the pressure sensor includes a third pressure sensor that detects the pressure of the gas in the mixing chamber; the processor is based on the pressure detected by the pressure sensor and the gas detected by the flow sensor. Flow rate, the step of calculating the gas flow rate output by the high-frequency oscillation generating device includes:所述处理器基于所述第三压力传感器检测的第三压力,结合所述第 一气体流速和所述第二气体流速,计算所述高频震荡发生设备输出的气体流速。The processor calculates the gas flow rate output by the high-frequency oscillation generating device based on the third pressure detected by the third pressure sensor in combination with the first gas flow rate and the second gas flow rate.
- 根据权利要求9所述的方法,其中,所述医用通气装置还包括:与所述高频震荡发生设备连接的压力发生器。The method according to claim 9, wherein the medical ventilation device further comprises: a pressure generator connected to the high-frequency oscillation generating device.
- 根据权利要求14所述的方法,其中,所述医用通气装置还包括第四压力传感器;所述处理器基于所述压力传感器检测的压力和所述流量传感器检测的气体流速,计算所述高频震荡发生设备输出的气体流速的步骤包括:The method according to claim 14, wherein the medical ventilation device further comprises a fourth pressure sensor; the processor calculates the high frequency based on the pressure detected by the pressure sensor and the gas flow rate detected by the flow sensor The steps to oscillate the gas flow rate output by the device include:所述第四压力传感器与所述压力发生器连接,测量所述压力发生器输出的第四压力;The fourth pressure sensor is connected to the pressure generator, and measures the fourth pressure output by the pressure generator;所述处理器基于所述第一支路和第二支路中气体的压力或所述混合腔中气体的压力,所述第四压力传感器检测的第四压力,以及所述第一支路和所述第二支路中的气体的流速,计算所述高频震荡发生设备输出的气体流速。The processor is based on the pressure of the gas in the first branch and the second branch or the pressure of the gas in the mixing chamber, the fourth pressure detected by the fourth pressure sensor, and the first branch and The flow rate of the gas in the second branch is calculated from the flow rate of the gas output by the high-frequency oscillation generating device.
- 根据权利要求10至15任一项所述的方法,其中,所述方法还包括:The method according to any one of claims 10 to 15, wherein the method further comprises:所述处理器基于计算得到的所述高频震荡发生设备输出的气体流速,控制所述第一支路的第一气体流速和所述第二支路输出的第二气体流速。The processor controls the first gas flow rate of the first branch and the second gas flow rate of the second branch based on the calculated gas flow rate output by the high-frequency oscillation generating device.
- 根据权利要求10至16任一项所述的方法,其中,The method according to any one of claims 10 to 16, wherein:所述第一支路还设有:第一流量控制器;所述第二支路还设有:第二流量控制器。The first branch is further provided with: a first flow controller; the second branch is further provided with: a second flow controller.
- 一种呼吸机,包括:A ventilator including:如权利要求1-8任一项所述的医用通气装置。The medical ventilation device according to any one of claims 1-8.
- 一种计算机可读存储介质,存储有可执行通气指令,用于引起医用通气装置的处理器执行时,实现权利要求9至17任一项所述的方法。A computer-readable storage medium storing executable ventilation instructions for causing the processor of a medical ventilation device to execute the method according to any one of claims 9 to 17.
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- 2019-07-19 WO PCT/CN2019/096912 patent/WO2021012127A1/en active Application Filing
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