WO2021002697A3 - 다제내성 병원성 세균을 효과적으로 사멸시키는 재조합 항균 단백질 Ablysin의 용도 - Google Patents

다제내성 병원성 세균을 효과적으로 사멸시키는 재조합 항균 단백질 Ablysin의 용도 Download PDF

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WO2021002697A3
WO2021002697A3 PCT/KR2020/008653 KR2020008653W WO2021002697A3 WO 2021002697 A3 WO2021002697 A3 WO 2021002697A3 KR 2020008653 W KR2020008653 W KR 2020008653W WO 2021002697 A3 WO2021002697 A3 WO 2021002697A3
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ablysin
present
bacteria
peptidoglycan
pathogenic bacteria
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WO2021002697A2 (ko
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김정민
진종숙
김석호
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경북대학교 산학협력단
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Priority to US17/281,952 priority Critical patent/US20210353720A1/en
Priority to EP20834993.6A priority patent/EP3845237A4/en
Publication of WO2021002697A2 publication Critical patent/WO2021002697A2/ko
Publication of WO2021002697A3 publication Critical patent/WO2021002697A3/ko

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Abstract

본 발명은 다제내성 병원성 세균을 효과적으로 사멸시키는 재조합 항균 단백질 Ablysin의 용도에 대한 것이다. 본 발명의 재조합 단백질 Ablysin는 항균제 내성 아시네토박터 바우마니, 클렙시엘라 뉴모니아, 대장균, 녹농균, 황색포도상구균, 그리고 장알균에 사멸능을 나타내어 이들 세균에 의해 유발되는 감염성 질환을 예방 또는 치료할 수 있으며, 항생제, 소독제, 식품 첨가제, 사료 첨가제 등에 광범위하게 활용될 수 있다. 특히, 상기 Ablysin은 세균의 세포벽 성분인 펩티도글리칸을 기질로 사용하여 펩티도글리칸 분해로 인한 세균 사멸능을 나타내고, 펩티도글리칸은 세균에만 존재하고 사람이나 동물에는 존재하지 않는 바, 본 발명의 Ablysin은 사람과 동물에 영향을 미치지 않아 안전하면서도 의약산업, 식품산업, 생명공학 등에 응용이 가능할 뿐 아니라, 다약제 항균제 내성에 대한 문제점 없이 세균을 목표장소 또는 목표물질에서 효과적으로 사멸시킬 수 있는 이점이 있다.
PCT/KR2020/008653 2019-07-03 2020-07-02 다제내성 병원성 세균을 효과적으로 사멸시키는 재조합 항균 단백질 Ablysin의 용도 WO2021002697A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US17/281,952 US20210353720A1 (en) 2019-07-03 2020-07-02 Use of recombinant antibacterial protein ablysin for effectively killing multidrug-resistant pathogenic bacteria
EP20834993.6A EP3845237A4 (en) 2019-07-03 2020-07-02 USE OF ANTIBACTERIAL RECOMBINATION PROTEIN ABLYSINE FOR EFFECTIVELY ELIMINATING PATHOGENIC BACTERIA MULTI-RESISTANT TO ANTIBIOTICS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020190080097A KR102225240B1 (ko) 2019-07-03 2019-07-03 다제내성 병원성 세균을 효과적으로 사멸시키는 재조합 항균 단백질 Ablysin의 용도
KR10-2019-0080097 2019-07-03

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WO2021002697A2 WO2021002697A2 (ko) 2021-01-07
WO2021002697A3 true WO2021002697A3 (ko) 2021-02-25

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US (1) US20210353720A1 (ko)
EP (1) EP3845237A4 (ko)
KR (1) KR102225240B1 (ko)
WO (1) WO2021002697A2 (ko)

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CN113249231B (zh) * 2021-05-21 2022-08-02 中国医学科学院医药生物技术研究所 来源于极地来源真菌的抗革兰阳性菌化合物及其制备方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160118994A (ko) * 2015-04-03 2016-10-12 건국대학교 글로컬산학협력단 Adk 단백질을 유효성분으로 포함하는 카바페넴 내성 그람음성균에 대한 항균용 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562958B1 (en) * 1998-06-09 2003-05-13 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Acinetobacter baumannii for diagnostics and therapeutics
AU2002306849A1 (en) * 2001-03-21 2002-10-08 Elitra Pharmaceuticals, Inc. Identification of essential genes in microorganisms
KR20110124028A (ko) 2010-05-10 2011-11-16 경북대학교 산학협력단 미생물 균막을 형성하는 신규 미생물 아시네토박터 바우마니
EP3152303B1 (en) * 2014-06-06 2021-11-24 The Hospital For Sick Children Soluble bacterial and fungal proteins and methods and uses thereof in inhibiting and dispersing biofilm
CN108348585B (zh) * 2015-09-02 2023-12-15 杜邦营养生物科学有限公司 糖苷水解酶及其在预防和/或治疗动物中的病原体感染中的用途
CN111971058A (zh) * 2017-12-12 2020-11-20 康特拉费克特公司 对铜绿假单胞菌具有细菌活性的溶素及其衍生物的鉴定

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160118994A (ko) * 2015-04-03 2016-10-12 건국대학교 글로컬산학협력단 Adk 단백질을 유효성분으로 포함하는 카바페넴 내성 그람음성균에 대한 항균용 조성물

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE Protein ANOYMOUS: "MULTISPECIES: glycoside hydrolase family 25 protein [Acinetobacter]", XP055781660, retrieved from NCBI Database accession no. WP_000163500 *
GARCIA-QUINTANILLA M., PULIDO M. R., MORENO-MARTINEZ P., MARTIN-PENA R., LOPEZ-ROJAS R., PACHON J., MCCONNELL M. J: "Activity of Host Antimicrobials against Multidrug-Resistant Acinetobacter baumannii Acquiring Colistin Resistance through Loss of Lipopolysaccharide", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 58, no. 5, 1 May 2014 (2014-05-01), pages 2972 - 2975, XP055781675, ISSN: 0066-4804, DOI: 10.1128/AAC.02642-13 *
GUANGTAO HUANG; XIAODONG SHEN; YALI GONG; ZHIWEI DONG; XIA ZHAO; WEI SHEN; JING WANG; FUQUAN HU; YIZHI PENG: "Antibacterial properties of Acinetobacter baumanniiphage Abp1 endolysin (PlyAB1)", vol. 14, no. 1, 681, 12 December 2014 (2014-12-12), pages 1 - 8, XP021207375, ISSN: 1471-2334, DOI: 10.1186/s12879-014-0681-2 *
MANDIN PIERRE; CHAREYRE SYLVIA; BARRAS FREDERIC: "A Regulatory Circuit Composed of a Transcription Factor, IscR, and a Regulatory RNA, RyhB, Controls Fe-S Cluster Delivery", MBIO, vol. 7, no. 5, pages 1 - 9, XP009523973, ISSN: 2150-7511, DOI: 10.1128/mBio.00966-16 *

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KR102225240B1 (ko) 2021-03-10
US20210353720A1 (en) 2021-11-18
EP3845237A2 (en) 2021-07-07
EP3845237A4 (en) 2022-07-20
WO2021002697A2 (ko) 2021-01-07
KR20210004153A (ko) 2021-01-13

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