WO2020259528A1 - 治疗特发性肺纤维化的方法 - Google Patents

治疗特发性肺纤维化的方法 Download PDF

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WO2020259528A1
WO2020259528A1 PCT/CN2020/097881 CN2020097881W WO2020259528A1 WO 2020259528 A1 WO2020259528 A1 WO 2020259528A1 CN 2020097881 W CN2020097881 W CN 2020097881W WO 2020259528 A1 WO2020259528 A1 WO 2020259528A1
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days
compound
group
formula
alkyl
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English (en)
French (fr)
Chinese (zh)
Inventor
赵焰平
王红军
姜媛媛
仲伟婷
赵静
李晶
刘伟娜
周丽莹
刘亚男
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Beijing Tide Pharmaceutical Co Ltd
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Beijing Tide Pharmaceutical Co Ltd
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Priority to CN202510159677.8A priority Critical patent/CN119868365A/zh
Priority to US17/621,719 priority patent/US12582653B2/en
Priority to CN202080045478.XA priority patent/CN114026072A/zh
Priority to JP2021576479A priority patent/JP7615061B2/ja
Priority to BR112021026214A priority patent/BR112021026214A2/pt
Priority to CA3144113A priority patent/CA3144113A1/en
Priority to EP20833444.1A priority patent/EP3992183A4/en
Priority to KR1020227002368A priority patent/KR20220029681A/ko
Priority to AU2020305979A priority patent/AU2020305979B2/en
Application filed by Beijing Tide Pharmaceutical Co Ltd filed Critical Beijing Tide Pharmaceutical Co Ltd
Publication of WO2020259528A1 publication Critical patent/WO2020259528A1/zh
Priority to IL289192A priority patent/IL289192A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Definitions

  • the present invention belongs to the field of biomedicine, and specifically relates to a method for preventing, alleviating and/or treating idiopathic pulmonary fibrosis, which includes administering an effective amount of the compound in the present application or a pharmaceutically acceptable compound thereof to an individual in need thereof Salts, esters, stereoisomers, polymorphs, solvates, N-oxides, isotopically labeled compounds, metabolites or prodrugs.
  • Idiopathic pulmonary fibrosis is a chronic and progressive lower respiratory tract fibrosis with unknown etiology, which has an increasing incidence. The disease is characterized by the gradual accumulation of extracellular matrix within the interstitium. Increased fibrosis leads to reduced lung function, and patients usually die of respiratory failure or other complications within 3 years of biopsy diagnosis.
  • corticosteroids such as prednisolone
  • immunosuppressive agents such as azathioprine
  • N-acetylcysteine has been proposed as a treatment option for IPF.
  • pirfenidone Another drug that has been approved for the treatment of IPF in Japan, Europe, India and Canada is pirfenidone, which has combined anti-inflammatory, anti-oxidant and anti-fibrotic effects in experimental models of IPF. It is the only drug that has been observed to increase progression-free survival. Currently, there is no evidence that current treatment strategies can reverse fibrosis in IPF; the goal of most therapies is to reduce the rate of disease development and/or prevent disease progression.
  • the present invention provides a method of preventing, alleviating and/or treating idiopathic pulmonary fibrosis, which comprises administering an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof to an individual in need thereof , Esters, stereoisomers, polymorphs, solvates, N-oxides, isotopically labeled compounds, metabolites or prodrugs:
  • Ring A is The above group is connected to the pyrimidine ring through one of the two positions marked with * or **, and the other position is connected to the carbonyl group;
  • R is selected from H and C 1-6 alkyl
  • R 2 is selected from H and C 1-6 alkyl
  • R 3 , R 4 , R 7 and R 8 are each independently selected from H, halogen, -NR 5 R 6 , -OH, C 1-6 alkyl and -OR 5 at each occurrence;
  • alkylene, alkyl, alkenyl, cycloalkyl, heterocyclyl, aryl, heteroaryl and aralkyl groups are each optionally selected by one or more independently selected from halogen, C 1 -6 alkyl and -OR 5 substituents;
  • R 5 and R 6 are independently selected from H, C 1-6 alkyl, C 3-10 cycloalkyl, 3-10 membered heterocyclic group, C 6-10 aryl, 5-14 membered Heteroaryl and C 6-12 aralkyl;
  • m is independently an integer of 0, 1, 2, or 3;
  • n is independently an integer of 0, 1, or 2.
  • the present invention provides the compound of the above formula (I) or a pharmaceutically acceptable salt, ester, stereoisomer, polymorph, solvate, N-oxide, isotope-labeled compound
  • a pharmaceutically acceptable salt, ester, stereoisomer, polymorph, solvate, N-oxide, isotope-labeled compound The use of metabolites or prodrugs in the preparation of drugs for preventing, relieving and/or treating idiopathic pulmonary fibrosis.
  • the present invention provides the compound of the above formula (I) or a pharmaceutically acceptable salt, ester, stereoisomer, polymorph, solvate, N-oxide, isotope-labeled compound , Metabolites or prodrugs, which are used to prevent, alleviate and/or treat idiopathic pulmonary fibrosis.
  • Figure 1A shows the changes in body weight of animals in each group during the test period of Example 2 (day 0 is the first day of bleomycin induction).
  • Figure 1B shows the change in body weight of each group of animals at the end of the test in Example 2.
  • Figure 2 shows the survival rate of each group of animals in the test of Example 2.
  • Figure 3 shows the white blood cell counts in the alveolar lavage fluid of each group of animals after the administration in Example 2.
  • Figure 4A shows the lung tissue fibrosis scores of the animals in each group after the administration of Example 2.
  • Figure 4B shows the representative Masson Trichome staining pathological photos of each group in Example 2.
  • Figure 5A shows the expression of TIMP-1 mRNA in the lung tissue of each group of animals after the end of the administration in Example 2.
  • Figure 5B shows the expression of COL1A1 mRNA in the lung tissue of each group of animals after the end of the administration in Example 2.
  • Figure 6 shows the white blood cell counts in the alveolar lavage fluid of each group of animals after the administration in Example 3.
  • Figure 7A shows the representative H&E staining pathological staining photos of each group in Example 3.
  • Figure 7B shows the lung injury scores of the animals in each group after the administration of Example 3.
  • Figure 8A shows a representative Masson Trichome stained pathological photograph of each group in Example 3.
  • Figure 8B shows the lung tissue fibrosis scores of the animals in each group after the administration of Example 3.
  • alkylene means a saturated divalent hydrocarbon group, preferably a saturated divalent hydrocarbon group having 1, 2, 3, 4, 5 or 6 carbon atoms, such as methylene, ethylene, Propylene or butylene.
  • alkyl is defined as a linear or branched saturated aliphatic hydrocarbon.
  • the alkyl group has 1 to 12, for example 1 to 6 carbon atoms.
  • C 1-6 alkyl refers to a linear or branched group of 1 to 6 carbon atoms (e.g., methyl, ethyl, n-propyl, isopropyl, n-butyl Group, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl or n-hexyl), which is optionally substituted by 1 or more (such as 1 to 3) suitable substituents
  • halogen substitution the group is called "haloalkyl” at this time) (for example, CH 2 F, CHF 2 , CF 3 , CCl 3 , C 2 F 5 , C 2 Cl 5
  • C 1-4 alkyl refers to a linear or branched aliphatic hydrocarbon chain of 1 to 4 carbon atoms (ie methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, Sec-butyl or tert-butyl).
  • alkenyl means a linear or branched monovalent hydrocarbon group that contains one double bond and has 2-6 carbon atoms (“C 2-6 alkenyl”).
  • the alkenyl group is, for example, vinyl, 1-propenyl, 2-propenyl, 2-butenyl, 3-butenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 2 -Hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 2-methyl-2-propenyl and 4-methyl-3-pentenyl.
  • the compound of the present invention contains an alkenylene group, the compound may exist in the form of pure E (ent ought), pure Z (zusammen) or any mixture thereof.
  • alkynyl means a monovalent hydrocarbon group containing one or more triple bonds, which preferably has 2, 3, 4, 5, or 6 carbon atoms, such as ethynyl or propynyl.
  • cycloalkyl refers to a saturated monocyclic or polycyclic (such as bicyclic) hydrocarbon ring (e.g., monocyclic, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl , Cyclooctyl, cyclononyl, or bicyclic, including spirocyclic, fused or bridged systems (such as bicyclo[1.1.1]pentyl, bicyclo[2.2.1]heptyl, bicyclo[3.2.1]octyl Or bicyclo[5.2.0]nonyl, decalinyl, etc.)), which is optionally substituted with 1 or more (such as 1 to 3) suitable substituents.
  • monocyclic such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl , Cyclooctyl, cyclon
  • the cycloalkyl group has 3 to 15 carbon atoms.
  • C 3-6 cycloalkyl refers to a saturated monocyclic or polycyclic (such as bicyclic) hydrocarbon ring (e.g., cyclopropyl, cyclobutyl, cyclopentyl or cyclic ring) of 3 to 6 ring carbon atoms Hexyl), which is optionally substituted with 1 or more (such as 1 to 3) suitable substituents, such as methyl substituted cyclopropyl.
  • cycloalkylene As used herein, the terms “cycloalkylene”, “cycloalkyl” and “hydrocarbon ring” refer to having, for example, 3-10 (suitably 3-8, more suitably 3-6) ring carbons Saturated (ie, “cycloalkylene” and “cycloalkyl”) or unsaturated (ie, having one or more double bonds and/or triple bonds in the ring) monocyclic or polycyclic hydrocarbon ring of atoms, which Including but not limited to (ylidene) cyclopropyl (ring), (ylidene) cyclobutyl (ring), (ylidene) cyclopentyl (ring), (ylidene) cyclohexyl (ring), (ylidene) cycloheptyl ( (Cyclo), (ylidene)cyclooctyl (ring), (ylidene)cyclononyl (ring), (ylidene)cyclohexenyl (ring
  • heterocyclyl refers to having, for example, 3-10 (suitably 3-8, more suitably 3-6) Ring atoms, at least one of which is a heteroatom selected from N, O, and S, and the remaining ring atoms are saturated (ie, heterocycloalkyl) or partially unsaturated (ie, have one or more in the ring Double bond and/or triple bond) cyclic group.
  • 3-10 membered (ylidene) heterocycle (yl) has 2-9 (such as 2, 3, 4, 5, 6, 7, 8 or 9) ring carbon atoms and is independently selected from N
  • One or more (for example, 1, 2, 3, or 4) heteroatoms of, O, and S are saturated or partially unsaturated (ylidene) heterocycles (groups).
  • heterocyclylene and heterocyclic examples include, but are not limited to: (ethylene) oxirane, (ethylene) aziridinyl, (azetidinyl), (ethylene) oxygen Oxetanyl (oxetanyl), (ylidene)tetrahydrofuranyl, (ylidene)dioxolinyl (dioxolinyl), (ylidene)pyrrolidinyl, (ylidene)pyrrolidonyl, (ylidene)imidazolidinyl, (ylidene) ) Pyrazolidinyl, (ylidene) pyrrolinyl, (ylidene) tetrahydropyranyl, (ylidene) piperidinyl, (ylidene) morpholinyl, (ylidene) dithialyl (dithianyl), (ylidene) Thiomorpholinyl, (ylidene)piperazinyl, or (tri
  • the group also encompasses bicyclic ring systems, including spirocyclic, fused or bridged systems (such as 8-azaspiro[4.5]decane, 3,9-diazaspiro[5.5]undecane, 2-nitrogen Heterobicyclo[2.2.2]octane etc.).
  • the heterocyclylene and heterocyclic (radical) groups may be optionally substituted with one or more (for example, 1, 2, 3, or 4) suitable substituents.
  • (arylene) and “aromatic ring” refer to an all-carbon monocyclic or fused-ring polycyclic aromatic group having a conjugated ⁇ -electron system.
  • C 6-10 (arylene)” and “C 6-10 aromatic ring” mean aromatic groups containing 6 to 10 carbon atoms, such as (phenylene) (Benzene ring) or ()naphthylene (naphthalene ring).
  • (Arylene) and aromatic ring are optionally substituted by 1 or more (such as 1 to 3) suitable substituents (e.g. halogen, -OH, -CN, -NO 2 , C 1-6 alkyl, etc.) .
  • (arylene) heteroaryl and “heteroaromatic ring” refer to monocyclic, bicyclic or tricyclic aromatic ring systems having 5, 6, 8, 9, 10, 11, 12, 13 or 14 ring atoms, especially 1 or 2 or 3 or 4 or 5 or 6 or 9 or 10 carbon atoms, and it contains at least one heteroatom which may be the same or different (the heteroatom is for example oxygen, nitrogen Or sulfur), and, in addition, may be benzo-fused in each case.
  • (ylidene)heteroaryl or “heteroaryl ring” is selected from (ylidene)thienyl, (ylidene)furanyl, (ylidene)pyrrolyl, (ylidene)oxazolyl, (ylidene)thiazolyl, (Sub)imidazolyl, (sub)pyrazolyl, (sub)isoxazolyl, (sub)isothiazolyl, (sub)oxadiazolyl, (sub)triazolyl, (sub)thiadiazolyl Etc., and their benzo derivatives; or (ylidene) pyridinyl, (ylidene) pyridazinyl, (ylidene) pyrimidinyl, (ylidene) pyrazinyl, (ylidene) triazinyl, etc., and their benzo derivative.
  • aralkyl preferably denotes an aryl or heteroaryl substituted alkyl group, wherein the aryl, heteroaryl and alkyl are as defined herein.
  • the aryl group may have 6-14 carbon atoms
  • the heteroaryl group may have 5-14 ring atoms
  • the alkyl group may have 1-6 carbon atoms.
  • Exemplary aralkyl groups include, but are not limited to, benzyl, phenylethyl, phenylpropyl, phenylbutyl.
  • halo or halogen group is defined to include F, Cl, Br, or I.
  • substituted means that one or more (eg, one, two, three, or four) hydrogens on the specified atom are replaced by a selection from the indicated group, provided that no more than the specified atom is present In the case of normal valence and the substitution forms a stable compound. Combinations of substituents and/or variables are only allowed when such combinations form stable compounds.
  • substituent can be (1) unsubstituted or (2) substituted. If the carbon of a substituent is described as being optionally substituted with one or more of the list of substituents, then one or more hydrogens on the carbon (to the extent of any hydrogens present) may be independently and/or together independently Optional substitution of selected substituents. If the nitrogen of a substituent is described as being optionally substituted with one or more of the list of substituents, then one or more hydrogens on the nitrogen (to the extent of any hydrogens present) may each be independently selected optionally Substituent replacement.
  • each substituent is selected independently of the other. Therefore, each substituent may be the same or different from another (other) substituent.
  • one or more means 1 or more than 1, such as 2, 3, 4, 5, or 10 under reasonable conditions.
  • the point of attachment of a substituent can be from any suitable position of the substituent.
  • the present invention also includes all pharmaceutically acceptable isotope-labeled compounds, which are the same as the compounds of the present invention, except that one or more atoms have the same atomic number but the atomic mass or mass number is different from the predominant atomic mass in nature. Or atomic substitution of mass number.
  • isotopes suitable for inclusion in the compounds of the present invention include, but are not limited to, isotopes of hydrogen (such as deuterium ( 2 H), tritium ( 3 H)); isotopes of carbon (such as 11 C, 13 C, and 14 C) ; Isotopes of chlorine (such as 36 Cl); isotopes of fluorine (such as 18 F); isotopes of iodine (such as 123 I and 125 I); isotopes of nitrogen (such as 13 N and 15 N); isotopes of oxygen (such as 15 O , 17 O and 18 O); phosphorus isotopes (such as 32 P); and sulfur isotopes (such as 35 S).
  • isotopes of hydrogen such as deuterium ( 2 H), tritium ( 3 H)
  • isotopes of carbon such as 11 C, 13 C, and 14 C
  • Isotopes of chlorine such as 36 Cl
  • isotopes of fluorine
  • Certain isotope-labeled compounds of the invention can be used in drug and/or substrate tissue distribution studies (such as analysis).
  • the radioisotopes tritium (i.e. 3 H) and carbon-14 (i.e. 14 C) are particularly useful for this purpose because they are easy to incorporate and easy to detect.
  • Substitution with positron emission isotopes (such as 11 C, 18 F, 15 O, and 13 N) can be used to test substrate receptor occupancy in positron emission tomography (PET) studies.
  • the isotopically-labeled compounds of the present invention can be prepared by methods similar to those described in the attached routes and/or examples and preparations by using appropriate isotopically-labeled reagents instead of previously used non-labeled reagents.
  • the pharmaceutically acceptable solvates of the present invention include those in which the crystallization solvent can be replaced by an isotope, for example, D 2 O, acetone-d 6 or DMSO-d 6 .
  • stereoisomer means an isomer due to at least one asymmetric center. In compounds with one or more (for example, one, two, three, or four) asymmetric centers, it can produce racemic mixtures, single enantiomers, diastereomeric mixtures, and individual The diastereomers. Certain individual molecules can also exist as geometric isomers (cis/trans). Similarly, the compounds of the present invention may exist in mixtures of two or more structurally different forms (commonly referred to as tautomers) in rapid equilibrium. Representative examples of tautomers include keto-enol tautomers, phenol-ketone tautomers, nitroso-oxime tautomers, imine-enamine tautomers Wait.
  • Solid lines can be used in this article Solid wedge Virtual wedge Depicts the chemical bonds of the compounds of the invention.
  • the use of a solid line to depict the bond to an asymmetric carbon atom is intended to indicate that all possible stereoisomers at that carbon atom (e.g., specific enantiomers, racemic mixtures, etc.) are included.
  • the use of real or imaginary wedges to depict bonds to asymmetric carbon atoms is intended to indicate that the stereoisomers shown exist. When present in a racemic mixture, use real and imaginary wedges to define relative stereochemistry, rather than absolute stereochemistry.
  • the compounds of the present invention are intended to be stereoisomers (which include cis and trans isomers, optical isomers (such as R and S enantiomers), diastereomers, Geometric isomers, rotamers, conformational isomers, atropisomers and mixtures thereof) exist in the form of.
  • the compounds of the present invention can exhibit more than one type of isomerism, and are composed of mixtures thereof (for example, racemic mixtures and diastereomeric pairs).
  • the present invention covers all possible crystalline forms or polymorphs of the compounds of the present invention, which can be a single polymorph or a mixture of more than one polymorph in any ratio.
  • compositions of the present invention may exist in free form for treatment, or, when appropriate, in the form of pharmaceutically acceptable derivatives thereof.
  • pharmaceutically acceptable derivatives include, but are not limited to, pharmaceutically acceptable salts, esters, solvates, N-oxides, metabolites, or prodrugs, which can be administered to patients in need thereof. After medication, the compound of the present invention or its metabolites or residues can be directly or indirectly provided. Therefore, when “the compound of the present invention” is referred to herein, it is also intended to cover the above-mentioned various derivative forms of the compound.
  • the pharmaceutically acceptable salts of the compounds of the present invention include acid addition salts and base addition salts thereof.
  • Suitable acid addition salts are formed from acids that form pharmaceutically acceptable salts. Examples include acetate, adipate, aspartate, benzoate, benzenesulfonate, bicarbonate/carbonate, bisulfate/sulfate, borate, camphorsulfonate , Citrate, cyclamate, ethanedisulfonate, ethanesulfonate, formate, fumarate, glucoheptonate, gluconate, glucuronate, hexafluorophosphate Salt, sea benzoate, hydrochloride/chloride, hydrobromide/bromide, hydroiodide/iodide, isethionate, lactate, malate, maleic acid Salt, malonate, methanesulfonate, methyl sulfate, naphthylate, 2-naphthalenesulfonate, nicotinate, nitrate, orotate, oxalate, palmi
  • Suitable base addition salts are formed from bases that form pharmaceutically acceptable salts. Examples include aluminum salt, arginine salt, benzathine penicillin salt, calcium salt, choline salt, diethylamine salt, diethanolamine salt, glycinate, lysine salt, magnesium salt, meglumine salt, ethanolamine salt, Potassium, sodium, tromethamine and zinc salts.
  • ester means an ester derived from each of the compounds of the general formula in this application, which includes physiologically hydrolyzable esters (which can be hydrolyzed under physiological conditions to release the free acid or alcohol form of the present invention Compound).
  • the compound of the present invention may itself be an ester.
  • the compound of the present invention may exist in the form of a solvate (preferably a hydrate), wherein the compound of the present invention contains a polar solvent as a structural element of the crystal lattice of the compound, particularly, for example, water, methanol or ethanol.
  • a polar solvent as a structural element of the crystal lattice of the compound, particularly, for example, water, methanol or ethanol.
  • the amount of polar solvent, especially water can be present in a stoichiometric or non-stoichiometric ratio.
  • N-oxides can be formed.
  • Nitrogen-containing heterocycle Those skilled in the art will also recognize that tertiary amines can form N-oxides.
  • metabolites of the compounds of the present invention that is, substances formed in the body when the compounds of the present invention are administered. Such products can be produced by, for example, oxidation, reduction, hydrolysis, amidation, deamidation, esterification, enzymatic hydrolysis, etc. of the administered compound. Therefore, the present invention includes metabolites of the compounds of the present invention, including compounds prepared by contacting the compound of the present invention with a mammal for a time sufficient to produce its metabolites.
  • the present invention further includes within its scope the prodrugs of the compounds of the present invention, which are certain derivatives of the compounds of the present invention that may themselves have less pharmacological activity or no pharmacological activity when administered to or on the body It can be converted into the compound of the present invention having the desired activity by, for example, hydrolytic cleavage.
  • prodrugs will be functional group derivatives of the compound, which are easily converted into the desired therapeutically active compound in vivo.
  • prodrugs please refer to "Pro-drugs as Novel Delivery Systems", Volume 14, ACS Symposium Series (T. Higuchi and V. Stella).
  • prodrugs of the present invention can be used, for example, by using certain parts known to those skilled in the art as “pro-moiety (e.g., “Design of Prodrugs", described in H. Bundgaard (Elsevier, 1985))" It is prepared by substituting appropriate functional groups present in the compounds of the present invention.
  • the present invention also encompasses compounds of the present invention containing protecting groups.
  • protecting groups In any process of preparing the compounds of the present invention, protection of sensitive groups or reactive groups on any relevant molecule may be necessary and/or desirable, thereby forming a chemically protected form of the compounds of the present invention. This can be achieved by conventional protecting groups, such as those described in T.W.Greene & P.G.M. Wuts, Protective Groups in Organic Synthesis, John Wiley & Sons, 1991, and these references are incorporated herein by reference. Using methods known in the art, the protecting group can be removed at an appropriate subsequent stage.
  • an effective amount refers to an amount sufficient to achieve the desired therapeutic effect under the conditions of administration, which leads to pathological symptoms, disease progression, improvement of physiological conditions related thereto, or induces resistance to the aforementioned diseases.
  • treating means reversing, alleviating, or inhibiting the disease or condition to which such term is applied or the progression of one or more symptoms of such a condition or condition, or Preventing such a disorder or condition or one or more symptoms of such a disorder or condition.
  • “Individual” as used herein includes human or non-human animals.
  • Exemplary human individuals include human individuals (referred to as patients) or normal individuals suffering from diseases such as the diseases described herein.
  • “non-human animals” include all vertebrates, such as non-mammals (such as birds, amphibians, reptiles) and mammals, such as non-human primates, livestock and/or domesticated animals (such as sheep, dogs). , Cats, cows, pigs, etc.).
  • the present invention provides a method of preventing, alleviating and/or treating idiopathic pulmonary fibrosis, which comprises administering to an individual in need thereof an effective amount of a compound of formula (I) or a pharmaceutically acceptable Salts, esters, stereoisomers, polymorphs, solvates, N-oxides, isotopically labeled compounds, metabolites or prodrugs:
  • Ring A is The above group is connected to the pyrimidine ring through one of the two positions marked with * or **, and the other position is connected to the carbonyl group;
  • R is selected from H and C 1-6 alkyl
  • R 2 is selected from H and C 1-6 alkyl
  • R 3 , R 4 , R 7 and R 8 are each independently selected from H, halogen, -NR 5 R 6 , -OH, C 1-6 alkyl and -OR 5 at each occurrence;
  • alkylene, alkyl, alkenyl, cycloalkyl, heterocyclyl, aryl, heteroaryl and aralkyl groups are each optionally selected by one or more independently selected from halogen, C 1 -6 alkyl and -OR 5 substituents;
  • R 5 and R 6 are independently selected from H, C 1-6 alkyl, C 3-10 cycloalkyl, 3-10 membered heterocyclic group, C 6-10 aryl, 5-14 membered Heteroaryl and C 6-12 aralkyl;
  • m is independently an integer of 0, 1, 2, or 3;
  • n is independently an integer of 0, 1, or 2.
  • ring A is The above group is connected to the pyrimidine ring through the position marked with *, and is connected to the carbonyl group through the position marked with **, wherein R 10 is selected from H and C 1-6 alkyl, preferably H or methyl.
  • ring A is preferably The above group is connected to the pyrimidine ring through the position marked with *, and to the carbonyl group through the position marked with **.
  • R is H
  • R 2 is H.
  • R 5 and R 6 are each independently selected from H, methyl and ethyl at each occurrence.
  • each occurrence of R 3 , R 4 , R 7 and R 8 is independently selected from H, F, Cl, Br, I, -NH 2 , -OH, methyl, trifluoro Methyl, -CH 2 -Ph, methoxy, ethoxy and -CH 2 OCH 3 .
  • R 3 is H.
  • R 4 is selected from H and halogen (e.g. F, Cl, Br or I), preferably H or F.
  • halogen e.g. F, Cl, Br or I
  • R 7 is selected from H and halogen (e.g. F, Cl, Br or I), preferably H or F.
  • halogen e.g. F, Cl, Br or I
  • R 8 is H.
  • each occurrence of R 9 is independently selected from H, C 1-6 alkyl, C 3-10 cycloalkyl, 3-10 membered heterocyclic group, C 6-10 aryl, 5-14 membered heteroaryl and C 6-12 aralkyl, preferably H.
  • each occurrence of R 10 is independently selected from H and C 1-6 alkyl, preferably H, methyl, ethyl, n-propyl or isopropyl, most preferably H Or methyl.
  • the present invention provides a method for preventing, alleviating and/or treating idiopathic pulmonary fibrosis, which comprises administering an effective amount of a compound of formula (II) or a pharmaceutically acceptable compound thereof to an individual in need thereof Salts, esters, stereoisomers, polymorphs, solvates, N-oxides, isotopically labeled compounds, metabolites or prodrugs of:
  • the present invention provides a method for preventing, alleviating and/or treating idiopathic pulmonary fibrosis, which comprises administering an effective amount of a compound of formula (III) or a pharmaceutically acceptable compound thereof to an individual in need thereof Salts, esters, stereoisomers, polymorphs, solvates, N-oxides, isotopically labeled compounds, metabolites or prodrugs of:
  • R 10 is H or methyl, preferably methyl.
  • the compound has the following structure:
  • the compound is prepared according to the method disclosed in WO 2019/001572 A1 (which is incorporated herein by reference).
  • the compound of formula (I), formula (II) or formula (III) or a pharmaceutically acceptable salt, ester, stereoisomer, polymorph, solvate is given at one time or in two, three or four doses.
  • the compound of formula (I), formula (II) or formula (III) or a pharmaceutically acceptable salt, ester, stereoisomer, polymorph, solvate, N-oxide, isotope-labeled compound, metabolite or prodrug is administered continuously for at least 3 days, at least 4 days, at least 5 days, at least 6 days, at least 7 days, at least 8 days, at least 9 days, at least 10 days, At least 11 days, at least 12 days, at least 13 days, at least 14 days, at least 15 days, at least 16 days, at least 17 days, at least 18 days, at least 19 days, at least 20 days, at least 21 days, at least 22 days, at least 23 Days, at least 24 days, at least 25 days, at least 1 month, at least 2 months, at least 3 months, at least 4 months, at least 5 months, at least 6 months, at least 1 year, or at least 2 years.
  • the compound of formula (I), formula (II) or formula (III) or a pharmaceutically acceptable salt, ester, stereoisomer, polymorph, solvate, N-oxide, isotope-labeled compounds, metabolites or prodrugs are administered by injection (such as intravenous, intraarterial, subcutaneous, intraperitoneal, intramuscular injection, including drip) or transdermally; or by oral or buccal administration , Nasal, transmucosal, topical, in the form of ophthalmic preparations or by inhalation.
  • the present invention covers any combination of the above embodiments.
  • the compound 128 used in the examples has the following structure, which is prepared according to the method disclosed in WO 2019/001572 A1.
  • CISBIO kinase detection kit HTRF KinEASE-STK S2 kit (62ST2PEC) was used for kinase IC 50 determination.
  • the kinase ROCK2 (01-119) used in the reaction was purchased from Carna Biosciences.
  • a 1 ⁇ kinase buffer with a DMSO concentration of 2.5% was used to prepare a compound solution of 10000 nM, and the above-mentioned kinase buffer containing DMSO was used to gradually dilute the compound to obtain 9 test compound solutions with different concentrations.
  • a positive hole containing all reagents except the compound
  • a negative hole containing all reagents except the test compound and kinase
  • 4 ⁇ L of the test compound solution was added to all reaction wells, and 4 ⁇ L of 2.5% DMSO solution was added to the control wells.
  • Example 2 BLM-induced mouse idiopathic pulmonary fibrosis (IPF) model tested the effect of compounds used to treat IPF
  • IPF 3mg/kg bleomycin
  • the animal groups are shown in Table 2.
  • the animals in each group were administered respectively: the normal group and the vehicle group animals were given vehicle 1 (vehicle 1 is: 20% PEG 400 + 5% Tween 80 + 75% ddH 2 O), compound 007 was administered The drug group was given compound 007 (prepared with vehicle 1) by gavage, the compound 128 administration group was given compound 128 (prepared with vehicle 1), and the pirfenidone administration group was given pirfenidone (vehicle 2: 0.2). % Methyl cellulose + 0.5% Tween 80 + 99.3% ddH 2 O).
  • the left lung of the animal was fixed for histopathological examination, and the lung injury was scored by Masson Trichome staining.
  • the scoring standard was as reported in Ashcroft T et al., Journal of clinical pathology.1988. After 100 times magnification, score each continuous field of view (ranging from 0 points (normal lung)) to 8 points (complete fibrous occlusion in the field of view), and calculate the average of the scores of 5 parts. The results are shown in the figure 4A and 4B.
  • Real-time fluorescent quantitative PCR method was used to detect the mRNA levels of lung tissue fibrosis-associated protein collagen 1A1 (COL1A1) and tissue inhibitor of metal matrix protein 1 (TIMP-1) in lung tissue after the administration.
  • the lung tissue fragments were transferred to a centrifuge tube containing 1 mL of TRIzol reagent (Invitrogen, catalog number 15596018), and the lung tissue was ground at low temperature by a tissue grinder, and the total RNA of the cells was extracted, using TransScript All-in-One First-Strand cDNA Synthesis SuperMix for qPCR (One-Step gDNA Removal) (full-style gold, catalog number AT341-02) kit reverse transcription to synthesize cDNA, and fluorescent quantitative PCR method to detect the mRNA expression of COL1A1 and TIMP-1 in lung tissue Variety.
  • ⁇ -actin gene is used as the internal reference gene to normalize the data; the primer sequences used are all from the PrimeBank website, and the website ID numbers are 34328108a1 (COL1A1 primer) and 6755795a1 (TIMP-1). Primers) and 6671509a1 ( ⁇ -actin primers), 3 pairs of primers were all synthesized by Invitech.
  • Example 3 Detecting the effect of different doses of compounds for the treatment of IPF in the BLM-induced mouse idiopathic pulmonary fibrosis (IPF) model
  • mice were randomly divided into 2 groups according to their body weight: a group of 15 mice were injected with 50 ⁇ L of normal saline into the airway of the animals; the other group of 90 mice were injected with 50 ⁇ L of Borai into the airway of the animals (2.5mg/kg) to establish IPF animal model.
  • groups were randomly divided according to the weight change (the difference between the weight on the seventh day after the establishment of the model and the day when the model was established), and the drug was administered for 14 consecutive days from the eighth day after the establishment of the animal model. Information is shown in Table 3.
  • the alveolar lavage fluid (BALF) was collected for white blood cell count.
  • Pulmonary fibrosis scoring standards refer to the "Standardized quantification of pulmonary fibrosis in histological samples"; the grade score of lung tissue damage is 0-16, mainly from inflammatory cell infiltration (0-4), bleeding (0-4), Interstitial and alveolar edema (0-4) and alveolar septum thickness (0-4) are evaluated in four aspects. The higher the score, the higher the degree of lung tissue damage.
  • compound 007 can significantly reduce the infiltration of white blood cells in the lungs ( Figure 6), lung injury ( Figures 7A and 7B) and the degree of fibrosis ( Figures 8A and 8B) are also significantly improved, of which compound 007-30
  • the therapeutic effect of the 100mpk and 100mpk dose groups is equivalent to that of the pirfenidone and nintedanib dose groups.
  • the compound 007-300mpk dose group is better than the pirfenidone and nintedanib dose groups in improving lung injury and fibrosis. Danib administration group. This indicates that compound 007 can play a therapeutic effect on IPF by reducing the infiltration of leukocytes in the lung, improving the degree of lung injury and pulmonary fibrosis.

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CN118215468A (zh) * 2021-11-16 2024-06-18 北京泰德制药股份有限公司 一种rock2抑制剂的纳米晶制剂及其制备方法
JP2024544572A (ja) * 2021-11-16 2024-12-03 北京泰徳製薬股▲フン▼有限公司 Ｒｏｃｋ２阻害剤のナノ結晶製剤およびその調製方法
WO2023088231A1 (zh) * 2021-11-16 2023-05-25 北京泰德制药股份有限公司 一种rock2抑制剂的纳米晶制剂及其制备方法
WO2023134688A1 (zh) * 2022-01-13 2023-07-20 武汉朗来科技发展有限公司 一种rock抑制剂的盐及盐的晶型、组合物和药物用途
CN116425745A (zh) * 2022-01-13 2023-07-14 武汉朗来科技发展有限公司 一种rock抑制剂的盐及盐的晶型、组合物和药物用途
WO2024078553A1 (zh) * 2022-10-13 2024-04-18 北京泰德制药股份有限公司 治疗尘肺病的方法
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