WO2020251156A1 - Content carrier for intestinal retention - Google Patents

Content carrier for intestinal retention Download PDF

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Publication number
WO2020251156A1
WO2020251156A1 PCT/KR2020/005021 KR2020005021W WO2020251156A1 WO 2020251156 A1 WO2020251156 A1 WO 2020251156A1 KR 2020005021 W KR2020005021 W KR 2020005021W WO 2020251156 A1 WO2020251156 A1 WO 2020251156A1
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Prior art keywords
carrier
intestine
contents
staying
transport body
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PCT/KR2020/005021
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French (fr)
Korean (ko)
Inventor
이세엽
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㈜한국원자력 엔지니어링
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Publication of WO2020251156A1 publication Critical patent/WO2020251156A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use

Definitions

  • the present invention relates to a carrier of contents for staying in the intestine, and more particularly, the contents such as orally administered drugs or lactic acid bacteria reach the intestine without being destroyed by stomach acid, so that effective drug treatment is possible, and in particular, colonoscopy of lactic acid bacteria is performed.
  • beneficial bacteria in the intestine are discharged together, and the contents carrier for staying in the intestine can relieve the discomfort caused by abdominal pain or indigestion of the digestive system or abnormal symptoms of the body's immune system that occur temporarily after examination.
  • beneficial bacteria in the intestine are discharged together, and the contents carrier for staying in the intestine can relieve the discomfort caused by abdominal pain or indigestion of the digestive system or abnormal symptoms of the body's immune system that occur temporarily after examination.
  • microcapsules have the advantage of being easy to administer orally because they have a very small spherical shape with a diameter of 5 to 100 ⁇ m, but like general foods, the time to stay in the small intestine or large intestine is short, so there is a disadvantage that it does not work sufficiently in the intestine .
  • Colonoscopy is performed for the diagnosis and treatment of polyps and colorectal cancer when gastrointestinal symptoms such as abdominal pain, constipation, diarrhea, and bloody stool are present.For the prevention and early diagnosis of colorectal cancer, even if there are no special symptoms, from 50 years old. It is recommended to undergo regular colonoscopy once a year, so it is one of the most commonly performed endoscopy tests in health examination centers and internal medicine clinics.
  • Colonoscopy is known as a test method for diagnosing inflammation, polyps, tumors, etc. that may occur in the large intestine by observing the large intestine by inserting an endoscope through the anus. In the colonoscopy, as well as the examination, a part of the tissue in the abnormal area can be removed and a biopsy can be performed immediately, and if there is a polyp, it can be removed directly.
  • Intestinal flora are bacteria that live normally in the intestine, and the roles of intestinal bacteria that have been identified so far are related to metabolism, nutrition, and energy use in the body, regulation of innate immunity and adaptive immunity, development and production of intestinal mucosal epithelium, and pathogens. Intrusion prevention and the like are known.
  • the present invention is to solve the conventional problems as described above, the purpose of which is to further extend the time that the contents such as drugs or lactic acid bacteria contained in the intestine stay in the intestine, so that the drug can sufficiently function in the intestine.
  • the contents such as drugs or lactic acid bacteria contained in the intestine stay in the intestine, so that the drug can sufficiently function in the intestine.
  • lactic acid bacteria it is not discharged even during intestinal washing for colonoscopy, and protects some beneficial bacteria to remain in the intestine, thereby reducing discomfort in the digestive system that may occur after colonoscopy, or discomfort due to abnormal symptoms of the immune system. It is to provide a carrier of contents for staying in the intestine that can be resolved.
  • the present invention is to provide a content carrier for staying in the intestine that can shorten the recovery time by rapidly discharging the contents contained in the carrier body into the intestine while the carrier body stays in the intestine.
  • the present invention is made of a transport body having a length of 1 to 10 mm long to facilitate oral administration, and the transport body is made of synthetic resin to have a seed-shaped appearance, Inside the transport body, an accommodation space for receiving contents for transport into the intestine is formed to communicate with the outside, and the contents are food for drugs, lactic acid bacteria or intestinal bacteria, and the contents are for discharging the contents inside the transport body to the outside. There is a feature of the content carrier for staying in the intestine further containing an expanding agent for.
  • the transport body is characterized by a content carrier for staying in the intestine having a seed-shaped appearance.
  • the content is characterized by a content carrier for staying in the intestine, which is food for drugs, lactic acid bacteria or intestinal bacteria.
  • the expanding agent is characterized in the contents carrier for intestinal retention, which is any one of baking powder, soda (sodium hydrogen carbonate; 2NaHCO3), yeast, alginic acid, natural brown algae extract, or cellulose. have.
  • the transport body is characterized by a content transport body for staying in the intestine made of a porous structure to form an accommodation space therein.
  • a coating layer having a plurality of holes communicating with the receiving space is formed on the surface of the conveying body, and the coating layer is characterized in a content carrier for staying in the intestine made of a plastic resistant to stomach acid.
  • the transport body is characterized by a content carrier for staying in the intestine formed by tableting a porous sponge formed by foaming a foamable resin into a seed shape.
  • the transport body is characterized by a content carrier for staying in the intestine having the same shape and size as that of melon seeds or watermelon seeds.
  • the contents carrier for staying in the intestine of the present invention having the above characteristic configuration, when oral administration by receiving contents such as drugs or lactic acid bacteria in the transport body, the contents can be protected from stomach acid and transported to the small intestine or large intestine.
  • the length of time the body stays in the intestine can be extended further.
  • the drug in the case of drugs, the drug can be sufficiently effective in the intestine, and in the case of lactic acid bacteria, it becomes food for bacteria in the intestine and can further activate the bacteria in the intestine.
  • the carrier body can be orally administered before intestinal rinsing to remain in the small intestine or large intestine, and when bacteria in the intestine are discharged by intestinal rinsing, some bacteria infiltrating into the carrier body
  • the present invention accommodates the expanding agent together with the contents in the receiving space of the transport body, and allows the expanding agent to expand in the intestine, so that the contents can be discharged more quickly within the transport body, whereby lactic acid bacteria are quickly discharged into the intestine. Since the proliferative activity is performed, the recovery period can be accelerated that much, and even if the contents are drugs, there is an effect of quickly exerting the effect of the drug.
  • FIG. 1 is a perspective view of a content carrier for staying in the intestine according to a first embodiment of the present invention.
  • FIG. 2 is a cross-sectional view taken along line A-A of FIG. 1;
  • Figure 3 is a perspective view showing another modified example of the contents carrier for staying in the intestine according to the present invention.
  • Figure 4 is a state of operation of the contents carrier for staying in the intestine according to the present invention.
  • FIG. 5 is a cross-sectional view of a content carrier for staying in the intestine according to a second embodiment of the present invention.
  • FIG. 1 and 2 are perspective and cross-sectional views showing a content carrier according to a first embodiment of the present invention, and as shown, the content carrier of the present invention has a size that can be administered orally, for example, a length (L) of a long width. It is provided with a transport body 10 made of 1 ⁇ 10mm.
  • a receiving space 11 communicating with the outside is formed inside the transport body 10 so as to accommodate the contents, for example, drugs or lactic acid bacteria (probiotics) or food of intestinal bacteria.
  • the contents may further include an expanding agent that expands in response to water in the intestine, and the expanding agent includes baking powder, soda (sodium hydrogen carbonate), yeast, alginate, natural brown algae extract, or It is preferable that it is any one of celluloses (for example, carboxymetal cellulose).
  • the expanding agent includes baking powder, soda (sodium hydrogen carbonate), yeast, alginate, natural brown algae extract, or It is preferable that it is any one of celluloses (for example, carboxymetal cellulose).
  • Alginic acid can take advantage of the property of swelling by attracting 200 to 300 times more water than its own weight, and natural brown algae extract contains a large amount of alginic acid, so it reacts with water safely in the intestine to increase its volume.
  • the transport body 10 in the first embodiment is made of a porous structure, and a plurality of small pores form an accommodation space 11 for accommodating contents.
  • the transport body 10 having a porous structure may be manufactured using a foamable resin, for example, polyurethane, polyethylene, or polypropylene, which is used for manufacturing a sponge having a plurality of pores.
  • the conveying body 10 by tableting the sponge to a size of 1 to 10 mm with a tableting machine, and the pore size is preferably 10 to 100 ⁇ m.
  • the strength of the porous sponge made of foamable resin can be adjusted according to the mixing ratio of the curing agent mixed with the foamable resin, and the size of the pores can be adjusted according to the mixing ratio of the foaming agent mixed with the foamable resin, and thus the strength and pore size of the sponge
  • the technique of setting is a known technique well known in the art.
  • the carrier body 10 of the present invention is preferably formed in an external shape having the shape and size of seeds such as melon seeds or watermelon seeds, and increases the absorption area of nutrients on the surface of the intestine, and food passes slowly to efficiently pass nutrients. Wrinkles and ridges are formed for absorption, and after eating melon and watermelon, melon seeds or watermelon seeds stay in the intestine longer.
  • the transport body 10 is provided with a configuration that is easy to get caught in intestinal wrinkles and ridges so that it can stay in the intestine longer.
  • a plurality of stripe-shaped protrusions 12 are provided on the circumferential surface of the transport body 10 do.
  • FIG. 3(a) and (b) are perspective views showing another modified example of the first embodiment, and one end of the carrying body 10 as in FIG. 3(a) to make it easy to get caught in intestinal wrinkles and ridges
  • a hook 13 in the shape of a fishing hook may be formed in the portion, or an irregular uneven portion 14 may be formed as shown in FIG. 3B.
  • the carrier body 10 After mixing any one of a liquid or gel-like content and a powdery expanding agent, for example, baking powder, baking soda, or yeast, the carrier body 10 is soaked and the expanding agent is placed in the accommodation space 12 in the carrier body 10. After allowing the contained contents to be accommodated, when the transport body 10 is administered orally and ingested, the transport body 10 passes through the stomach and moves to the small intestine or large intestine.
  • a powdery expanding agent for example, baking powder, baking soda, or yeast
  • the contents buried on the surface of the transport body 10 and the contents in the receiving space 11 close to the surface are partially destroyed by stomach acid, but the contents of the central part are protected by the transport body 10 and are in an effective state. It can be carried to the small or large intestine.
  • the appearance of the transport body 10 passing through the stomach and reaching the small intestine or large intestine is formed in the form of seeds such as melon seeds or watermelon seeds, which are difficult to pass through by wrinkles and ridges of the small intestine or large intestine, so the transport body 10 It is possible to further extend the time to stay in the intestine, thereby securing a time for the contents contained in the receiving space 11 inside the transport body 10 to be discharged into the intestine.
  • the drug when the content is a drug, the drug can be sufficiently effective in the intestine, and in the case of lactic acid bacteria, it can further activate the intestinal bacteria.
  • the transport body 10 since the expanding agent that expands by reacting with water is included in the contents of the transport body 10, when the expanding agent in the transport body 10 reacts to water and expands when it reaches the intestine, the transport body (10) Since the contents are pushed out and discharged, the contents can be discharged more quickly from the transport body 10.
  • the present invention when the transport body 10 in the form and size of melon seeds or watermelon is ingested before bowel washing in preparation for colonoscopy, the transport body 10 stays in the intestine and some bacteria in the intestine are transported. (10) It can be accommodated by penetrating into the accommodation space 11 made of an inner porous structure.
  • the transporting body 10 which is not easy to discharge, remains in the intestine as it is, so it is possible to stay in the intestine without releasing some of the bacteria in the intestine. It can quickly recover the imbalance of the intestinal flora caused by the discharge of
  • FIG. 5 is a cross-sectional view showing a content carrier according to a second embodiment of the present invention, in the configuration of the first embodiment, a coating layer 15 is further formed on the surface of the carrier body 10, and accommodated in the coating layer 15 A plurality of holes 16 communicating with the space 11 are formed.
  • the coating layer 15 is preferably formed of a plastic that is resistant to stomach acid.
  • the contents can be accommodated in the receiving space 11 inside the transport body 10 through the plurality of holes 916 formed in the coating layer 15, and the coating layer 15 is resistant to stomach acid. Since it is formed of plastic, the contents accommodated in the receiving space 11 of the transport body 10 can be protected from stomach acid by the transport body 10 and the coating layer 15, thereby reducing the stomach compared to the configuration of the first embodiment. It can further increase the amount of contents that pass through and reach the small intestine or large intestine.
  • the drug when the content is a drug, the drug can be sufficiently effective in the intestine, and in the case of lactic acid bacteria, it can further activate the intestinal bacteria.

Abstract

The present invention provides a content carrier for intestinal retention, which is able to further prolong the residence time of contents, such as a drug or lactobacilli, accommodated in the carrier in the intestines, whereby, in the case of a drug, the efficacy of the drug in the intestines may be sufficient, and in the case of lactobacilli, some beneficial bacteria are protected to stay in the intestines without being excreted even during colon cleansing for a colonoscopy, and thus can relieve discomfort of the digestive system or discomfort due to abnormal symptoms of the immune system, which may occur after colonoscopy. The content carrier of the present invention comprises a carrying body which has a size sufficient to be administered orally and a seed-shaped appearance, and has formed therein an accommodation space capable of accommodating contents including a swelling agent. In addition, the carrying body has the same shape and size as those of a melon seed or a watermelon seed, and has, at an end portion at one side thereof, a fish hook-shaped fixing means or an irregular uneven portion.

Description

장내 체류를 위한 내용물 운반체Content carrier for stay in the intestine
본 발명은 장내 체류를 위한 내용물 운반체에 관한 것으로, 더욱 상세하게는 경구투여한 약물이나 유산균 등의 내용물이 위산에 의해 소멸되지 않고 장내까지 도달함으로써 효율적인 약물치료가 가능하고 특히 유산균의 대장내시경 검사를 위해 미리 장을 비우는 과정에서 장내의 유익균이 함께 배출되어 검사 후 일시적으로 발생하는 소화기관의 복통이나 소화불량 또는 신체의 면역체계 이상 증상에 따른 불편함을 해소할 수 있는 장내 체류를 위한 내용물 운반체에 관한 것이다.The present invention relates to a carrier of contents for staying in the intestine, and more particularly, the contents such as orally administered drugs or lactic acid bacteria reach the intestine without being destroyed by stomach acid, so that effective drug treatment is possible, and in particular, colonoscopy of lactic acid bacteria is performed. In the process of emptying the intestine beforehand, beneficial bacteria in the intestine are discharged together, and the contents carrier for staying in the intestine can relieve the discomfort caused by abdominal pain or indigestion of the digestive system or abnormal symptoms of the body's immune system that occur temporarily after examination. About.
일반적으로, 경구 투여된 약물은 대부분 위에서 위산에 의해 흡수되어 소멸되므로 소장이나 대장까지 도달하기 어렵다. 따라서 종래에도 약물을 수용할 수 있는 다공질의 마이크로캡슐을 이용하여 장 내까지 약물을 도달시키는 기술이 개발되어 있었다.In general, drugs administered orally are absorbed by gastric acid in the stomach and disappeared, so it is difficult to reach the small intestine or large intestine. Therefore, conventionally, a technology for reaching the drug into the intestine has been developed using a porous microcapsule capable of accommodating drugs.
그러나 마이크로캡슐은 직경이 5~100㎛로서 아주 작은 구형상으로 되어 경구투여가 용이하다는 장점은 있지만, 일반적인 음식물과 마찬가지로 소장이나 대장 내에 머무는 시간이 짧아 장내에서 충분이 약효를 작용시키지 못하는 단점이 있다.However, microcapsules have the advantage of being easy to administer orally because they have a very small spherical shape with a diameter of 5 to 100 μm, but like general foods, the time to stay in the small intestine or large intestine is short, so there is a disadvantage that it does not work sufficiently in the intestine .
대장내시경 검사는 복통, 변비, 설사, 혈변 등의 위장관계 증상이 있을 때, 용종과 대장암의 진단 및 치료를 위해 시행하고 있으며, 대장암 예방 및 조기 진단을 위해 특별한 증상이 없더라도 50세부터 5년에 한번씩 정기적으로 대장내시경 검사를 받을 것을 권고하고 있어 건강검진센터나 내과의원에서 많이 시행되는 내시경 검사중 하나이다.Colonoscopy is performed for the diagnosis and treatment of polyps and colorectal cancer when gastrointestinal symptoms such as abdominal pain, constipation, diarrhea, and bloody stool are present.For the prevention and early diagnosis of colorectal cancer, even if there are no special symptoms, from 50 years old. It is recommended to undergo regular colonoscopy once a year, so it is one of the most commonly performed endoscopy tests in health examination centers and internal medicine clinics.
대장내시경 검사는, 항문을 통해 내시경을 삽입하여 대장을 관찰함으로써 대장에 생길 수 있는 염증, 용종, 종양 등을 진단하는 검사 방법으로 알려져 있다. 대장내시경 검사는 검사 뿐만아니라 이상이 있는 부위의 조직을 일부 떼내어 바로 조직검사를 할 수 있으며, 용종이 있을 경우 직접 제거하기도 한다.Colonoscopy is known as a test method for diagnosing inflammation, polyps, tumors, etc. that may occur in the large intestine by observing the large intestine by inserting an endoscope through the anus. In the colonoscopy, as well as the examination, a part of the tissue in the abnormal area can be removed and a biopsy can be performed immediately, and if there is a polyp, it can be removed directly.
이러한 대장내시경 검사는 내시경의 시야 확보를 위해 검사 3일 전부터는 씨있는 과일, 소화되지 않는 잡곡 및 단단한 섬유질의 채소는 피하고, 검사 전날 자정부터는 금식하도록 하고 있으며, 또한 검사 일정에 맞추어 처방된 관장약을 안내에 따라 많은 물과 함께 복용하도록 함으로써 장을 깨끗하게 비워 정확한 검사가 이루어지도록 하고 있다.These colonoscopy tests require you to avoid seeds with fruits, undigested grains and hard fiber vegetables from 3 days before the test, and fast from midnight on the day before the test to secure the field of view of the endoscope, and also take prescribed enemas according to the test schedule. By following the instructions and taking it with a lot of water, the intestine is cleared and an accurate examination is made.
그러나, 대장내시경 검사를 위해 장을 깨끗하게 비우는 과정에서 장내에서 소화나 면역기능을 담당하는 유익균까지 배출됨에 따라, 장내세균총의 균형이 깨지게 된다. 장내세균총은 장내에서 정상적으로 서식하는 세균들로서, 현재까지 밝혀진 장내세균의 역할은 체내의 대사, 영양, 에너지 이용과 관련된 역할, 선천 면역과 적응 면역의 조절, 장관 내점막 상피의 발달과 생성, 병원체의 침입방지 등이 알려져 있다.However, in the process of clearing the intestine for colonoscopy, as beneficial bacteria responsible for digestion or immune function are discharged from the intestine, the balance of the intestinal flora is broken. Intestinal flora are bacteria that live normally in the intestine, and the roles of intestinal bacteria that have been identified so far are related to metabolism, nutrition, and energy use in the body, regulation of innate immunity and adaptive immunity, development and production of intestinal mucosal epithelium, and pathogens. Intrusion prevention and the like are known.
따라서, 검사 후 일시적이지만 설사, 과민성 대장 증상, 병원균 감염이 용이, 대장 운동의 불규칙성 등 소화계통에 이상이 발생하고, 심하게는 면역체계의 이상 증상까지 발생하여 불편을 초래하고 있다. 이를 위해 대장 내시경 검사 후 장 건강에 좋은 프로바이오틱스와 같은 유산균을 섭취할 수 있으나, 장내세균총의 균형을 정상적으로 회복하는데 까지 시간이 오래 걸린다는 단점이 있다.Therefore, although it is temporary after the test, abnormalities in the digestive system such as diarrhea, irritable bowel symptoms, easy pathogen infection, irregularity in bowel movements, and severely abnormal symptoms of the immune system occur, causing discomfort. To this end, after colonoscopy, lactic acid bacteria such as probiotics that are good for intestinal health can be ingested, but there is a disadvantage in that it takes a long time to restore the balance of the intestinal flora.
본 발명은 상기와 같은 종래의 문제점을 해결하기 위한 것으로, 그 목적은 내부에 수용한 약물이나 유산균 등의 내용물이 장내에 머무는 시간을 더욱 연장시킬 수 있도록 하여 약물의 경우 장내에서 약효가 충분히 작용할 수 있도록 하고, 유산균의 경우 대장내시경 검사를 위한 장세척시에도 배출되지 않고 일부 유익균을 장내에 남아 있도록 보호함으로써 대장내시경 검사후 발생할 수 있는 소화계통의 불편함이나 면역체계의 이상 증상으로 인한 불편함을 해소할 수 있는 장내 체류를 위한 내용물 운반체를 제공하는데 있다.The present invention is to solve the conventional problems as described above, the purpose of which is to further extend the time that the contents such as drugs or lactic acid bacteria contained in the intestine stay in the intestine, so that the drug can sufficiently function in the intestine. In the case of lactic acid bacteria, it is not discharged even during intestinal washing for colonoscopy, and protects some beneficial bacteria to remain in the intestine, thereby reducing discomfort in the digestive system that may occur after colonoscopy, or discomfort due to abnormal symptoms of the immune system. It is to provide a carrier of contents for staying in the intestine that can be resolved.
또한 본 발명은 운반몸체가 장내에 머무는 동안 운반몸체에 수용된 내용물을 장내에 신속하게 배출시킴으로써 유산균의 경우 장내에서 더욱 빨리 증식하여 회복시간을 단축시킬 수 있는 장내 체류를 위한 내용물 운반체를 제공하는데 있다.In addition, the present invention is to provide a content carrier for staying in the intestine that can shorten the recovery time by rapidly discharging the contents contained in the carrier body into the intestine while the carrier body stays in the intestine.
상기의 목적을 달성하기 위하여 본 발명은, 경구투여가 용이하도록 장폭(長幅) 길이가 1~10mm 크기인 운반몸체로 이루어지고, 상기 운반몸체는 씨앗 형태의 외형을 가지도록 합성수지로 제조되며, 상기 운반몸체 내부에는 장내에 운반하기 위한 내용물을 수용하는 수용공간이 외부와 통하도록 형성되며, 상기 내용물은 약물, 유산균 또는 장내 세균의 먹이이고, 상기 내용물에는 운반몸체 내부의 내용물을 외부로 배출하기 위한 팽창제가 더 포함되는 장내 체류를 위한 내용물 운반체에 특징이 있다.In order to achieve the above object, the present invention is made of a transport body having a length of 1 to 10 mm long to facilitate oral administration, and the transport body is made of synthetic resin to have a seed-shaped appearance, Inside the transport body, an accommodation space for receiving contents for transport into the intestine is formed to communicate with the outside, and the contents are food for drugs, lactic acid bacteria or intestinal bacteria, and the contents are for discharging the contents inside the transport body to the outside. There is a feature of the content carrier for staying in the intestine further containing an expanding agent for.
또한 본 발명에 있어서, 상기 운반몸체는 씨앗 형태의 외형을 가지는 장내 체류를 위한 내용물 운반체에 특징이 있다. In addition, in the present invention, the transport body is characterized by a content carrier for staying in the intestine having a seed-shaped appearance.
또한 상기 본 발명에 있어서, 상기 내용물은 약물, 유산균 또는 장내 세균의 먹이인 장내 체류를 위한 내용물 운반체에 특징이 있다.In addition, in the present invention, the content is characterized by a content carrier for staying in the intestine, which is food for drugs, lactic acid bacteria or intestinal bacteria.
이때, 상기 팽창제는 베이킹파우더(baking powder), 소다(탄산수소 나트륨; 2NaHCO3), 이스트(yeast), 알긴산 (Alginate), 천연갈조류 추출물 또는 셀룰로오스류 중에서 어느 하나인 장내 체류를 위한 내용물 운반체에 특징이 있다.At this time, the expanding agent is characterized in the contents carrier for intestinal retention, which is any one of baking powder, soda (sodium hydrogen carbonate; 2NaHCO3), yeast, alginic acid, natural brown algae extract, or cellulose. have.
또한 본 발명에 있어서, 상기 운반몸체는 내부에 수용공간을 형성하도록 다공질 구조로 이루어진 장내 체류를 위한 내용물 운반체에 특징이 있다.In addition, in the present invention, the transport body is characterized by a content transport body for staying in the intestine made of a porous structure to form an accommodation space therein.
또한 본 발명에 있어서, 상기 운반몸체 표면에는 수용공간과 통하는 다수의 구멍을 가지는 코팅층이 형성되며, 상기 코팅층은 위산에 강한 프라스틱으로 이루어진 장내 체류를 위한 내용물 운반체에 특징이 있다.In addition, in the present invention, a coating layer having a plurality of holes communicating with the receiving space is formed on the surface of the conveying body, and the coating layer is characterized in a content carrier for staying in the intestine made of a plastic resistant to stomach acid.
또한 본 발명에 있어서, 상기 운반몸체는 발포성 수지를 발포 성형하여 이루어진 다공질의 스펀지를 씨앗 형상으로 타정하여 형성된 장내 체류를 위한 내용물 운반체에 특징이 있다.In addition, in the present invention, the transport body is characterized by a content carrier for staying in the intestine formed by tableting a porous sponge formed by foaming a foamable resin into a seed shape.
또한 상기 본 발명에 있어서, 운반몸체는 참외씨 또는 수박씨와 동일한 형태 및 크기를 가지는 장내 체류를 위한 내용물 운반체에 특징이 있다.In addition, in the present invention, the transport body is characterized by a content carrier for staying in the intestine having the same shape and size as that of melon seeds or watermelon seeds.
또한 상기 본 발명에 있어서, 운반몸체의 일측 끝단부에 낚시바늘 형상의 고정구 또는 불규칙성 요철부가 형성된 장내 체류를 위한 내용물 운반체에 특징이 있다.In addition, in the present invention, there is a feature in the contents carrier for staying in the intestine in which a hook-shaped fixture or irregular irregularities are formed at one end of the carrying body.
또한 상기 본 발명에 있어서, 운반몸체의 표면에 장폭 방향으로 줄무늬 형태의 돌출부가 형성된 장내 체류를 위한 내용물 운반체에 특징이 있다.In addition, in the present invention, there is a feature of the content carrier for staying in the intestine in which a stripe-shaped protrusion is formed on the surface of the carrier body in the long width direction.
상기의 특징적 구성을 가지는 본 발명의 장내 체류를 위한 내용물 운반체에 의하면, 운반몸체 내에 약물이나 유산균 등의 내용물을 수용하여 경구 투여할 경우 내용물을 위산으로부터 보호하여 소장이나 대장까지 운반할 수 있고, 운반몸체가 장내에 머무는 시간을 더욱 연장할 수 있다. 이로 인해 약물의 경우 장내에서 약효를 충분히 발휘할 수 있고, 유산균의 경우 장내의 세균 먹이가 되어 장내의 세균을 더욱 활성화시킬 수 있다. According to the contents carrier for staying in the intestine of the present invention having the above characteristic configuration, when oral administration by receiving contents such as drugs or lactic acid bacteria in the transport body, the contents can be protected from stomach acid and transported to the small intestine or large intestine. The length of time the body stays in the intestine can be extended further. For this reason, in the case of drugs, the drug can be sufficiently effective in the intestine, and in the case of lactic acid bacteria, it becomes food for bacteria in the intestine and can further activate the bacteria in the intestine.
또한 본 발명은, 대장내시경 검사시 장세척 전에 운반몸체를 경구투여하여 소장이나 대장에 머물게 할 수 있고, 장세척에 의해 장내의 세균이 배출될 때, 운반몸체 내에 침투된 일부 세균은 운반몸체와 함께 장내에 남아 있도록 함으로써 대장내시경 검사후 깨진 장내세균총의 균형을 신속히 회복시켜 소화계통이나 면역체계의 이상 발생으로 인한 불편함을 해소할 수 있다.In addition, in the present invention, during colonoscopy, the carrier body can be orally administered before intestinal rinsing to remain in the small intestine or large intestine, and when bacteria in the intestine are discharged by intestinal rinsing, some bacteria infiltrating into the carrier body By allowing them to remain in the intestine together, the balance of broken intestinal flora after colonoscopy can be quickly restored and discomfort caused by abnormalities in the digestive system or immune system can be relieved.
또한 본 발명은 운반몸체의 수용공간에 내용물과 함께 팽창제를 수용하고, 장내에서 팽창제가 팽창되게 함으로써 운반몸체 내에서 내용물을 더욱 신속하게 배출할 수 있고, 이로써 유산균의 경우, 신속하게 장내로 배출되어 증식활동을 하게 되므로, 회복기간을 그만큼 앞당길 수 있고, 내용물이 약물인 경우에도 약의 효력을 신속하게 발휘하는 효과가 있다.In addition, the present invention accommodates the expanding agent together with the contents in the receiving space of the transport body, and allows the expanding agent to expand in the intestine, so that the contents can be discharged more quickly within the transport body, whereby lactic acid bacteria are quickly discharged into the intestine. Since the proliferative activity is performed, the recovery period can be accelerated that much, and even if the contents are drugs, there is an effect of quickly exerting the effect of the drug.
도 1은 본 발명의 제1 실시예에 따른 장내 체류를 위한 내용물 운반체의 사시도.1 is a perspective view of a content carrier for staying in the intestine according to a first embodiment of the present invention.
도 2는 도 1의 A-A선 단면도.2 is a cross-sectional view taken along line A-A of FIG. 1;
도 3은 본 발명에 따른 장내 체류를 위한 내용물 운반체의 다른 변형예를 나타낸 사시도.Figure 3 is a perspective view showing another modified example of the contents carrier for staying in the intestine according to the present invention.
도 4는 본 발명에 따른 장내 체류를 위한 내용물 운반체의 작용 상태도.Figure 4 is a state of operation of the contents carrier for staying in the intestine according to the present invention.
도 5는 본 발명의 제2 실시예에 따른 장내 체류를 위한 내용물 운반체의 단면도.5 is a cross-sectional view of a content carrier for staying in the intestine according to a second embodiment of the present invention.
이하, 본 발명에 따른 장내 체류를 위한 내용물 운반체의 바람직한 실시예를 첨부도면에 의거하여 상세하게 설명한다.Hereinafter, a preferred embodiment of the contents carrier for staying in the intestine according to the present invention will be described in detail with reference to the accompanying drawings.
도 1 및 도 2는 본 발명의 제1 실시예에 따른 내용물 운반체를 나타낸 사시도 및 단면도로서, 도시된 바와 같이 본 발명의 내용물 운반체는, 경구투여 가능한 크기, 예를 들면 장폭의 길이(L)가 1~10mm로 이루어진 운반몸체(10)를 구비한다. 1 and 2 are perspective and cross-sectional views showing a content carrier according to a first embodiment of the present invention, and as shown, the content carrier of the present invention has a size that can be administered orally, for example, a length (L) of a long width. It is provided with a transport body 10 made of 1 ~ 10mm.
운반몸체(10) 내부에는 내용물, 예를 들면 약물이나 유산균(프로바이오틱스) 또는 장내 세균의 먹이를 수용할 수 있도록 외부와 통하는 수용공간(11)이 형성된다.A receiving space 11 communicating with the outside is formed inside the transport body 10 so as to accommodate the contents, for example, drugs or lactic acid bacteria (probiotics) or food of intestinal bacteria.
또한 내용물에는 장내에서 물에 반응하여 팽창하는 팽창제를 더 포함할 수 있고, 팽창제는 베이킹파우더(baking powder), 소다류(탄산수소 나트륨), 이스트(yeast), 알긴산(Alginate), 천연갈조류 추출물 또는 셀룰로오스류(예를 들면, 카르복시메탈 셀룰로오스) 중에서 어느 하나인 것이 바람직하다.In addition, the contents may further include an expanding agent that expands in response to water in the intestine, and the expanding agent includes baking powder, soda (sodium hydrogen carbonate), yeast, alginate, natural brown algae extract, or It is preferable that it is any one of celluloses (for example, carboxymetal cellulose).
알긴산은 자기의 무게보다 200~300 배의 물을 끌어들여 팽창하는 성질을 이용할 수 있고, 천연갈조류 추출물은 알긴산을 다량 함유하고 있어 장내에서 안전하게 물과 반응하여 부피를 증가시킨다. Alginic acid can take advantage of the property of swelling by attracting 200 to 300 times more water than its own weight, and natural brown algae extract contains a large amount of alginic acid, so it reacts with water safely in the intestine to increase its volume.
제1 실시예에서의 운반몸체(10)는, 다공질 구조로 이루어져 다수의 작은 기공이 내용물을 수용하는 수용공간(11)을 형성하도록 되어 있다. 다공질 구조를 가지는 운반몸체(10)는, 다수의 기공을 가지는 스펀지의 제조에 사용되는 발포성수지, 예를 들면 폴리우레탄, 폴리에틸렌, 폴리프로필렌을 이용하여 제조할 수 있다.The transport body 10 in the first embodiment is made of a porous structure, and a plurality of small pores form an accommodation space 11 for accommodating contents. The transport body 10 having a porous structure may be manufactured using a foamable resin, for example, polyurethane, polyethylene, or polypropylene, which is used for manufacturing a sponge having a plurality of pores.
즉, 발포성수지로 스펀지를 발포 성형한 후, 타정기계로 스펀지를 1~10mm의 크기로 타정함으로써 운반몸체(10)를 제조할 수 있고, 기공의 크기는 10~100㎛인 것이 바람직하다.That is, after foaming the sponge with a foamable resin, it is possible to manufacture the conveying body 10 by tableting the sponge to a size of 1 to 10 mm with a tableting machine, and the pore size is preferably 10 to 100 μm.
발포성수지로 제조되는 다공성 스펀지의 강도는 발포성수지에 혼합되는 경화제의 혼합비에 따라 조절할 수 있고, 기공의 크기는 발포성수지에 혼합되는 발포제의 혼합비에 따라 조절할 수 있으며, 이와 같이 스펀지의 강도와 기공크기를 설정하는 기술은 당업계에서는 잘 알려져 있는 공지기술이다. The strength of the porous sponge made of foamable resin can be adjusted according to the mixing ratio of the curing agent mixed with the foamable resin, and the size of the pores can be adjusted according to the mixing ratio of the foaming agent mixed with the foamable resin, and thus the strength and pore size of the sponge The technique of setting is a known technique well known in the art.
본 발명의 운반몸체(10)는 참외씨 또는 수박씨와 같은 씨앗의 모양과 크기를 가지는 외형으로 형성하는 것이 바람직한 것으로, 장내의 표면에는 영양소의 흡수 면적을 증가시키고 음식물이 천천히 통과시켜 영양소를 효율적으로 흡수하기 위한 주름과 융털이 형성되어 있고, 참외와 수박을 먹은 후, 참외씨 또는 수박씨는 장내에 더 오래 머무는 것에 착안한 것이다.The carrier body 10 of the present invention is preferably formed in an external shape having the shape and size of seeds such as melon seeds or watermelon seeds, and increases the absorption area of nutrients on the surface of the intestine, and food passes slowly to efficiently pass nutrients. Wrinkles and ridges are formed for absorption, and after eating melon and watermelon, melon seeds or watermelon seeds stay in the intestine longer.
또한 운반몸체(10)에는 장의 주름과 융털에 걸리기 쉬운 구성이 구비되어 장내 체류를 더 오래 할 수 있도록 된 것으로, 이를 위해 운반몸체(10)의 둘레 표면에는 줄무늬 모양의 돌출부(12)를 복수개 구비한다. In addition, the transport body 10 is provided with a configuration that is easy to get caught in intestinal wrinkles and ridges so that it can stay in the intestine longer.To this end, a plurality of stripe-shaped protrusions 12 are provided on the circumferential surface of the transport body 10 do.
도 3의 (a) 및 (b)는 제1 실시예의 다른 변형예를 나타낸 사시도로서, 장의 주름과 융털에 걸리기 쉽도록 하기 위해 도 3의 (a)에서와 같이 운반몸체(10)의 일측 끝단부에 낚시바늘 형상의 고정구(13)를 형성하거나, 도 3의 (b)에서와 같이 불규칙성 요철부(14)를 형성하여도 좋다. 3(a) and (b) are perspective views showing another modified example of the first embodiment, and one end of the carrying body 10 as in FIG. 3(a) to make it easy to get caught in intestinal wrinkles and ridges A hook 13 in the shape of a fishing hook may be formed in the portion, or an irregular uneven portion 14 may be formed as shown in FIG. 3B.
이러한 구성으로 이루어진 본 발명의 제1 실시예에 따른 장내 체류를 위한 내용물 운반체의 작용을 설명하면 다음과 같다.The operation of the contents carrier for staying in the intestine according to the first embodiment of the present invention having such a configuration will be described as follows.
액상 또는 겔상의 내용물과 분말상태의 팽창제, 예를 들면 베이킹 파우더, 베이킹 소다 또는 이스트 중 어느 하나를 혼합한 후, 운반몸체(10)를 담가 운반몸체(10) 내의 수용공간(12)에 팽창제가 포함된 내용물이 수용되도록 한 후, 운반몸체(10)를 경구 투여하여 섭취하면, 운반몸체(10)는 위를 통과하여 소장이나 대장까지 이동하게 된다.After mixing any one of a liquid or gel-like content and a powdery expanding agent, for example, baking powder, baking soda, or yeast, the carrier body 10 is soaked and the expanding agent is placed in the accommodation space 12 in the carrier body 10. After allowing the contained contents to be accommodated, when the transport body 10 is administered orally and ingested, the transport body 10 passes through the stomach and moves to the small intestine or large intestine.
이 과정에서 운반몸체(10)의 표면에 묻은 내용물과, 표면에서 가까운 수용공간(11) 내의 내용물은 위산에 의해 일부 소멸되지만, 중앙부분의 내용물은 운반몸체(10)에 의해 보호되어 유효한 상태로 소장이나 대장까지 운반할 수 있다.In this process, the contents buried on the surface of the transport body 10 and the contents in the receiving space 11 close to the surface are partially destroyed by stomach acid, but the contents of the central part are protected by the transport body 10 and are in an effective state. It can be carried to the small or large intestine.
이어서 위를 통과하여 소장이나 대장에 도달한 운반몸체(10)의 외형은 소장이나 대장의 주름과 융털에 의해 통과가 쉽지 않은 참외씨 또는 수박씨와 같은 씨앗 형태로 형성된 것이므로, 운반몸체(10)가 장내에 머무는 시간을 더욱 연장할 수 있고, 이로써 운반몸체(10) 내부의 수용공간(11)에 수용된 내용물이 장내에 배출될 수 있는 시간을 확보할 수 있다.Subsequently, the appearance of the transport body 10 passing through the stomach and reaching the small intestine or large intestine is formed in the form of seeds such as melon seeds or watermelon seeds, which are difficult to pass through by wrinkles and ridges of the small intestine or large intestine, so the transport body 10 It is possible to further extend the time to stay in the intestine, thereby securing a time for the contents contained in the receiving space 11 inside the transport body 10 to be discharged into the intestine.
또한 도 4에 도시된 바와 같이, 운반몸체(10)의 둘레표면에 형성한 줄무늬 모양의 돌출부(12)와, 운반몸체(10)의 일측 끝단부에 형성한 낚시바늘 형상의 고정구(13) 또는 불규칙성 요철부(14)에 의해서는, 운반몸체(10)가 소장이나 대장을 통과할 때, 장의 주름(S1)과 융털(S2)에 걸리기 쉬운 구조이므로, 운반몸체(10)가 장내에 체류할 수 있는 확률을 더욱 높여주고, 이로 인해 더욱 많은 운반몸체(10)를 소장이나 대장에 머물게 하여 더욱 많은 약물 또는 유산균을 장내에 배출할 수 있다.In addition, as shown in Fig. 4, a stripe-shaped protrusion 12 formed on the circumferential surface of the transport body 10, and a fishing hook-shaped fixture 13 formed at one end of the transport body 10, or Due to the irregular irregularities 14, when the transport body 10 passes through the small intestine or large intestine, it is a structure that is easy to get caught in the intestinal wrinkles (S1) and ridges (S2), so that the transport body 10 can stay in the intestine. It is possible to further increase the probability of being able to, thereby allowing more of the carrier body 10 to stay in the small intestine or large intestine, thereby allowing more drugs or lactic acid bacteria to be discharged into the intestine.
따라서 내용물이 약물인 경우, 장내에서 약효를 충분히 발휘할 수 있고, 유산균의 경우, 장내 세균을 더욱 더 활성화시킬 수 있다. Therefore, when the content is a drug, the drug can be sufficiently effective in the intestine, and in the case of lactic acid bacteria, it can further activate the intestinal bacteria.
더욱이, 본 발명은 물과 반응하여 팽창하는 팽창제가 운반몸체(10)내의 내용물에 포함되어 있는 것이므로, 장내에 도달한 상태에서 운반몸체(10) 내의 팽창제가 물에 반응하여 팽창하게 되면, 운반몸체(10) 내의 내용물이 밖으로 밀려 배출되므로 내용물을 운반몸체(10)로부터 더욱 신속하게 배출할 수 있다. Moreover, in the present invention, since the expanding agent that expands by reacting with water is included in the contents of the transport body 10, when the expanding agent in the transport body 10 reacts to water and expands when it reaches the intestine, the transport body (10) Since the contents are pushed out and discharged, the contents can be discharged more quickly from the transport body 10.
또한 본 발명은, 참외씨 또는 수박씩 형태 및 크기로 된 운반몸체(10)는 대장내시경 검사 준비시 장세척 전에 섭취하게 되면, 운반몸체(10)가 장내에 머물면서 장내의 일부 세균이 운반몸체(10) 내부의 다공질 구조로 이루어진 수용공간(11)에 침투하여 수용될 수 있다. In addition, the present invention, when the transport body 10 in the form and size of melon seeds or watermelon is ingested before bowel washing in preparation for colonoscopy, the transport body 10 stays in the intestine and some bacteria in the intestine are transported. (10) It can be accommodated by penetrating into the accommodation space 11 made of an inner porous structure.
따라서 장 내부를 깨끗하게 비울 때에도 배출이 쉽지 않은 운반몸체(10)는 그대로 장내에 남게 되므로, 결국 장내에 있던 세균의 일부를 배출시키지 않고 장내에 머물게 할 수 있으며, 이로 인해 대장내시경 검사 후, 장내 세균의 배출로 인해 발생하는 장내세균총 불균형 상태를 빠르게 회복시킬 수 있다.Therefore, even when emptying the intestine cleanly, the transporting body 10, which is not easy to discharge, remains in the intestine as it is, so it is possible to stay in the intestine without releasing some of the bacteria in the intestine. It can quickly recover the imbalance of the intestinal flora caused by the discharge of
도 5는 본 발명의 제2 실시예에 따른 내용물 운반체를 나타낸 단면도로서, 제1 실시예의 구성에 있어서, 운반몸체(10)의 표면에 코팅층(15)을 더 형성하고, 코팅층(15)에는 수용공간(11)과 통하는 다수의 구멍(16)을 형성한 것이다. 코팅층(15)은 위산에 강한 프라스틱으로 형성하는 것이 바람직하다. 5 is a cross-sectional view showing a content carrier according to a second embodiment of the present invention, in the configuration of the first embodiment, a coating layer 15 is further formed on the surface of the carrier body 10, and accommodated in the coating layer 15 A plurality of holes 16 communicating with the space 11 are formed. The coating layer 15 is preferably formed of a plastic that is resistant to stomach acid.
이러한 제2 실시예에 의하면, 코팅층(15)에 형성된 다수의 구멍(916)을 통해 운반몸체(10) 내부의 수용공간(11)에 내용물을 수용할 수 있고, 코팅층(15)은 위산에 강한 프라스틱으로 형성한 것이므로, 운반몸체(10)의 수용공간(11)에 수용된 내용물은 운반몸체(10)와 코팅층(15)에 의해 위산으로부터 보호될 수 있고, 이로써 제1 실시예의 구성에 비하여 위를 통과하여 소장이나 대장까지 도달하는 내용물의 양을 더욱 증가시킬 수 있다. According to this second embodiment, the contents can be accommodated in the receiving space 11 inside the transport body 10 through the plurality of holes 916 formed in the coating layer 15, and the coating layer 15 is resistant to stomach acid. Since it is formed of plastic, the contents accommodated in the receiving space 11 of the transport body 10 can be protected from stomach acid by the transport body 10 and the coating layer 15, thereby reducing the stomach compared to the configuration of the first embodiment. It can further increase the amount of contents that pass through and reach the small intestine or large intestine.
따라서 내용물이 약물인 경우, 장내에서 약효를 충분히 발휘할 수 있고, 유산균의 경우, 장내 세균을 더욱 더 활성화시킬 수 있다.Therefore, when the content is a drug, the drug can be sufficiently effective in the intestine, and in the case of lactic acid bacteria, it can further activate the intestinal bacteria.
지금까지 설명된 실시예는 본 발명의 바람직한 실시예를 설명한 것에 불과하고, 본 발명의 권리범위는 설명된 실시예에 한정되는 것은 아니며, 본 발명의 기술적 사상과 특허청구범위 내에서 이 분야의 당업자에 의하여 다양한 변경, 변형 또는 치환이 가능할 것이며, 그와 같은 실시예들은 본 발명의 범위에 속하는 것으로 이해되어야 한다.The embodiments described so far are merely describing preferred embodiments of the present invention, and the scope of the present invention is not limited to the described embodiments, and those skilled in the art within the technical spirit and claims of the present invention Various changes, modifications, or substitutions may be made by this, and such embodiments are to be understood as being within the scope of the present invention.
(부호의 설명)(Explanation of code)
10 : 운반몸체 11 : 수용공간10: transport body 11: receiving space
12 : 돌출부 13 : 고정구12: protrusion 13: fixture
14 : 요철부 15 : 코팅층14: uneven portion 15: coating layer
16 : 구멍16: hole

Claims (7)

  1. 경구투여가 용이하도록 장폭(長幅) 길이가 1~10mm 크기인 운반몸체로 이루어지고, 상기 운반몸체는 씨앗 형태의 외형을 가지도록 합성수지로 제조되며, 상기 운반몸체 내부에는 장내에 운반하기 위한 내용물을 수용하는 수용공간이 외부와 통하도록 형성되며, 상기 내용물은 약물, 유산균 또는 장내 세균의 먹이이고, 상기 내용물에는 운반몸체 내부의 내용물을 외부로 배출하기 위한 팽창제가 더 포함되는 것을 특징으로 하는 장내 체류를 위한 내용물 운반체.To facilitate oral administration, it consists of a transport body with a length of 1 to 10 mm in length, and the transport body is made of synthetic resin to have a seed-shaped appearance, and the contents for transport into the intestine inside the transport body Intestinal cavity, characterized in that the receiving space for receiving the is formed to communicate with the outside, and the contents are food for drugs, lactic acid bacteria or intestinal bacteria, and the contents further include an expanding agent for discharging the contents inside the transport body to the outside. Content carrier for stay.
  2. 제 1 항에 있어서, 상기 운반몸체는 참외씨 또는 수박씨와 동일한 형태 및 크기를 가지는 것을 특징으로 하는 장내 체류를 위한 내용물 운반체.The contents carrier for staying in the intestine according to claim 1, wherein the carrier body has the same shape and size as that of melon seeds or watermelon seeds.
  3. 제 1항에 있어서, 상기 팽창제는 베이킹파우더, 소다류, 이스트, 알긴산, 천연갈조류 추출물 또는 셀룰로오스류 중에서 어느 하나인 것을 특징으로 하는 장내 체류를 위한 내용물 운반체.The content carrier for staying in the intestine according to claim 1, wherein the expanding agent is any one of baking powder, soda, yeast, alginic acid, natural brown algae extract, or cellulose.
  4. 제 1 항에 있어서, 상기 운반몸체는 발포성수지를 발포 성형하여 이루어진 다공질의 스펀지를 씨앗 형상으로 타정하여 형성된 것을 특징으로 하는 장내 체류를 위한 내용물 운반체. The contents carrier for staying in the intestine according to claim 1, wherein the carrier body is formed by tableting a porous sponge formed by foam molding a foamable resin into a seed shape.
  5. 제 1 항에 있어서, 상기 운반몸체의 표면에 장폭 방향으로 줄무늬 형태의 요철부가 형성된 것을 특징으로 하는 장내 체류를 위한 내용물 운반체.The contents carrier for staying in the intestine according to claim 1, wherein a stripe-shaped uneven portion is formed on the surface of the carrier body in a long width direction.
  6. 제 1 항에 있어서, 상기 운반몸체의 일측 끝단부에 낚시바늘 형상의 고정구 또는 불규칙성 요철부가 형성된 것을 특징으로 하는 장내 체류를 위한 내용물 운반체.The contents carrier for staying in the intestine according to claim 1, wherein a hook-shaped fixture or irregular irregularities are formed at one end of the conveying body.
  7. 제 1 항에 있어서, 상기 운반몸체 표면에는 수용공간과 통하는 다수의 구멍을 가지는 코팅층이 형성되며, 상기 코팅층은 위산에 강한 플라스틱으로 이루어진 것을 특징으로 하는 장내 체류를 위한 내용물 운반체.The content carrier for staying in the intestine according to claim 1, wherein a coating layer having a plurality of holes communicating with the receiving space is formed on the surface of the carrier body, and the coating layer is made of plastic resistant to stomach acid.
PCT/KR2020/005021 2019-03-15 2020-04-14 Content carrier for intestinal retention WO2020251156A1 (en)

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