WO2020243975A1 - Utilisation d'une composition nutraceutique dans l'alimentation animale - Google Patents

Utilisation d'une composition nutraceutique dans l'alimentation animale Download PDF

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Publication number
WO2020243975A1
WO2020243975A1 PCT/CN2019/090447 CN2019090447W WO2020243975A1 WO 2020243975 A1 WO2020243975 A1 WO 2020243975A1 CN 2019090447 W CN2019090447 W CN 2019090447W WO 2020243975 A1 WO2020243975 A1 WO 2020243975A1
Authority
WO
WIPO (PCT)
Prior art keywords
benzoic acid
animal
derivative
limited
feed
Prior art date
Application number
PCT/CN2019/090447
Other languages
English (en)
Inventor
Hong Liu
Jingcheng Zhang
Jose-Otavio SORBARA
Jinlong WU
Original Assignee
Dsm Ip Assets B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets B.V. filed Critical Dsm Ip Assets B.V.
Priority to PCT/CN2019/090447 priority Critical patent/WO2020243975A1/fr
Priority to US17/615,225 priority patent/US20220225638A1/en
Priority to PCT/EP2020/065227 priority patent/WO2020245121A1/fr
Priority to CN202080039796.5A priority patent/CN113950249A/zh
Priority to EP20730255.5A priority patent/EP3979814A1/fr
Priority to BR112021024514A priority patent/BR112021024514A2/pt
Publication of WO2020243975A1 publication Critical patent/WO2020243975A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry

Definitions

  • the present invention relates to a novel use of a nutraceutical composition for animals, especially poultry, comprising as active ingredient benzoic acid, derivatives or metabolites thereof.
  • nutraceutical denotes a usefulness in both the nutritional and pharmaceutical field of application.
  • the nutraceutical compositions can find use as a complete animal feed (diet) , as supplement to animal feed, and as pharmaceutical formulations for enteral or parenteral application which may be solid formulations, or liquid formulations.
  • animal feed compositions comprising benzoic acid or salts thereof can be used to minimize the emission of odoriferous ammonia from organic wastes, especially animal excrements and manure.
  • benzoic acid and salts thereof have the advantage of being able to improve growth performance of an animal subjected to coccidiosis vaccine challenge.
  • improvement of the growth performance can be represented by the increase of weight gain (WG) and/or increase of feed intake (FI) and/or decrease of feed conversion ratio (FCR) of the animals with supplementation of benzoic acid or derivatives or metabolites thereof, compared to the animals without supplementation of benzoic acid or derivatives or metabolites thereof.
  • WG weight gain
  • FI feed intake
  • FCR feed conversion ratio
  • the present invention relates to a composition
  • a composition comprising benzoic acid or a derivative of benzoic acid capable of giving rise to free benzoic acid in vivo for improving growth performance of an animal subjected to coccidiosis vaccine challenge.
  • the present invention also relates to the novel use of benzoic acid or a derivative of benzoic acid for improving growth performance of an animal subjected to coccidiosis vaccine challenge.
  • the invention further relates to a method for improving growth performance of an animal subjected to coccidiosis vaccine challenge.
  • This method comprises administering to the animal an effective amount of benzoic acid or a derivative of benzoic acid.
  • animal in the present invention includes all animals including human.
  • animals are non-ruminants, and ruminants.
  • Ruminant animals include, for example, animals such as sheep, goat, and cattle, e.g. cow such as beef cattle and dairy cows.
  • the animal is a non-ruminant animal.
  • non-ruminant animals include but are not limited to horses, rabbits; pig or swine (including but not limited to, piglets, growing pigs, and sows) and poultry.
  • the animal is poultry.
  • the term “poultry” refers to domesticated birds kept by humans for their eggs, their meat or their feathers, including but not limited to turkeys, ducks and chickens (including but not limited to broiler chicks, layers) , goose, pigeon.
  • Benzoic acid is commercially available (for example as supplied by DSM Nutritional Products, Kaiseraugst, Switzerland) or can easily be prepared by a skilled person using processes and methods well-known in the prior art.
  • derivatives of benzoic acid which can give rise to benzoic acid in vivo include salts of benzoic acid such as the alkali metal-alkaline earth metal-and ammonium benzoates.
  • Benzoic acid or a derivative thereof capable of giving rise to benzoic acid in vivo may be administered to the animals as a component of a nutraceutical composition which is conventionally fed to animals.
  • benzoic acid and derivatives thereof may be suitably administered to the animals as a component of the animal feed additive, or animal feed or in their drinking water.
  • the amount of benzoic acids or a derivative thereof administered to the animal is in the range from 0.001%to 5%based on the total weight of each feed fed to the animal. This amount may, however, be higher if the function of benzoic acid or a derivative thereof is also to control the pH of the animal excreta fed on such a diet in order to suppress the emission of ammonia from the excreta. Such higher amounts are suitably limited to a maximum of about 10%based on the total animal feed composition.
  • the amount of benzoic acid or of a derivative thereof in the final animal feed is in the range from 50 mg/kg to 1000 mg/kg feed, preferably in the range of 100 mg/kg to 500 mg/kg, most preferably in the range of 200 mg/kg to 250 mg/kg feed.
  • benzoic acid or a derivative of benzoic acid being used in an amount sufficient to provide a daily dosage of 5 mg per kg body weight to about 80 mg per kg body weight, preferably 10 mg per kg body weight to about 40 mg per kg body weight, of the subject to which it is to be administered.
  • Benzoic acid or a derivative thereof may be used in combination with conventional ingredients present in an animal feed composition (diet) such as calcium carbonates, elelctrolytes such as ammonium chloride, proteins such as soya bean meal, wheat, starch, sunflower meal, corn, meat and bone meal, amino acids, animal fat, vitamins and trace minerals.
  • Diet animal feed composition
  • the ratio of the electrolyte to the benzoic acid or a derivative thereof is suitably in the range from 0.5 : 1 to 5 : 1 w/w, preferably from 1.5 : 1 to 3 . 1 w/w.
  • Benzoic acid or a derivative thereof of the present invention may also be used in combination with other ingredients such as fat-soluble vitamins, and/or water soluble vitamins, and/or trace minerals, and/or macro minerals, in the nutraceutical composition, the animal feed additive, or animal feed or drinking water.
  • fat soluble vitamins include but are not limited to vitamin A, vitamin D 3 , vitamin E, and vitamin K, e.g. vitamin K 3 .
  • water soluble vitamins include but are not limited to vitamin B 12 , biotin and choline, vitamin B 1 , vitamin B 2 , vitamin B 6 , niacin, folic acid and panthothenate, e.g. Ca-D-panthothenate.
  • trace minerals include but are not limited to manganese, zinc, iron, copper, iodine, selenium, and cobalt.
  • macro minerals include but are not limited to calcium, phosphorus and sodium.
  • Benzoic acid or a derivative thereof is particularly effective to improve growth performance of an animal subjected to coccidiosis vaccine challenge.
  • Example 2 shows the effects of benzoic acid on weight gain, feed intake and feed conversion ratio in broiler chickens.
  • a total of 600 day-old male broiler chickens (Arbor Acres Plus) were sorted by body weight and randomly assigned to 3 dietary treatments each with 8 replicates and 25 birds per pen.
  • the treatments including a non-challenge group (PC) , a challenge group (NC) , and NC supplemented with benzoic acid (1000 mg/kg feed) .
  • the diets were formulated based on wheat, corn and soybean meal. All diets were in pelleted form and formulated according to the recommendation of China NY/T33-2004.
  • the basal diets were prepared in mash form as indicated in Table 1, then the basal diet was subdivided into 3 experimental diets, appropriate amounts of tested feed additives were mixed with a small quantity of basal diet as a premix which was then added to the feed to get the final concentration, according to the treatment. After mixing, the feed was pelleted at 75-80°C.
  • Vitamin-mineral premix provided (per kg of diet) Vitamin A 8250 IU, Vitamin D 3 2187.5 IU, Hy-D 69 ⁇ g, Vitamin E 41.25 IU, Vitamin K 3 5 mg, Vitamin B 1 2.5 mg, Vitamin B 2 8.75 mg, Vitamin B 6 5 mg, Vitamin B 12 0.025 mg, Biotin 0.25 mg, Folic acid 2.5 mg, Niacinamide 50 mg, D-pantothenic acid 15 mg, Fe 120 mg, Cu 10 mg, Mn 110 mg, Zn 90 mg, I 0.5 mg, Se 0.25 mg, Choline chloride 400 mg.
  • the birds were reared in floor pens on fresh wood shaving bedding in an environmentally controlled room and received 23L: 1D of lighting program during the first week and 20D: 4D afterward until the end of the study.
  • the temperature of the room was maintained at 32 ⁇ 1°C on the day of arrival and adapted according to the age specific requirements of the chicks.
  • Birds were offered starter diets during 0-21 d and grower diet during 21-35 d. Feed and water were provided ad libitum.
  • the birds in challenge groups were received a coccidial vaccine (Coccivac Merck Animal Health) , which contained live oocysts of E. tenella, E. mivati, E. maxima and E.
  • acervuline with 2-fold dose in a 0.5 ml sterile water by gavage. Because of the small volume, non-challenged birds were not given a placebo gavage. Pen weight and feed intake were measured at 0, 21 and 35 days of age, dead animals were monitored twice daily and the weights of dead birds were recorded for the calculation of FCR.
  • the experiment was a completely randomized design with 6 treatments.
  • the data were analyzed using the General Linear Model procedure of SPSS (version 22.0) .
  • SPSS version 22.0
  • Each pen served as an experimental unit.
  • Comparisons of the treatment means were performed with Tukey’s test followed by contrast procedures at P ⁇ 0.05.
  • Benzoic acid supplementation improves growth performance of broiler chickens subjected to coccidiosis challenge.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Fodder In General (AREA)
  • Feed For Specific Animals (AREA)

Abstract

L'invention concerne une composition comprenant de l'acide benzoïque ou un dérivé d'acide benzoïque pour améliorer les performances de croissance d'un animal soumis à un défi vaccinal contre la coccidiose, et l'utilisation d'acide benzoïque ou d'un dérivé d'acide benzoïque pour améliorer les performances de croissance d'un animal soumis à un défi vaccinal contre la coccidiose.
PCT/CN2019/090447 2019-06-07 2019-06-07 Utilisation d'une composition nutraceutique dans l'alimentation animale WO2020243975A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
PCT/CN2019/090447 WO2020243975A1 (fr) 2019-06-07 2019-06-07 Utilisation d'une composition nutraceutique dans l'alimentation animale
US17/615,225 US20220225638A1 (en) 2019-06-07 2020-06-02 Use of benzoic acid and essential oil compounds for improving growth performance
PCT/EP2020/065227 WO2020245121A1 (fr) 2019-06-07 2020-06-02 Utilisation d'acide benzoïque et de composés d'huile essentielle pour améliorer les performances de croissance
CN202080039796.5A CN113950249A (zh) 2019-06-07 2020-06-02 苯甲酸和精油化合物用于改善生长性能的用途
EP20730255.5A EP3979814A1 (fr) 2019-06-07 2020-06-02 Utilisation d'acide benzoïque et de composés d'huile essentielle pour améliorer les performances de croissance
BR112021024514A BR112021024514A2 (pt) 2019-06-07 2020-06-02 Uso de ácido benzoico e compostos de óleo essencial para melhorar o desempenho de crescimento

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2019/090447 WO2020243975A1 (fr) 2019-06-07 2019-06-07 Utilisation d'une composition nutraceutique dans l'alimentation animale

Publications (1)

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WO2020243975A1 true WO2020243975A1 (fr) 2020-12-10

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0683985A1 (fr) * 1994-05-27 1995-11-29 Verdugt B.V. Contrôle de l'émission d'ammoniac et de l'odeur d'excréments d'animaux
CN103749975A (zh) * 2013-12-26 2014-04-30 广州英赛特生物技术有限公司 2-羟基苯甲酸锌作为饲用高剂量氧化锌替代品的应用
CN104686814A (zh) * 2015-02-16 2015-06-10 广州英赛特生物技术有限公司 对甲基苯甲酸或其盐作为动物饲料添加剂的应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0683985A1 (fr) * 1994-05-27 1995-11-29 Verdugt B.V. Contrôle de l'émission d'ammoniac et de l'odeur d'excréments d'animaux
CN103749975A (zh) * 2013-12-26 2014-04-30 广州英赛特生物技术有限公司 2-羟基苯甲酸锌作为饲用高剂量氧化锌替代品的应用
CN104686814A (zh) * 2015-02-16 2015-06-10 广州英赛特生物技术有限公司 对甲基苯甲酸或其盐作为动物饲料添加剂的应用

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