WO2020220471A1 - Endoscopic imaging-guided photothermal treatment apparatus - Google Patents

Endoscopic imaging-guided photothermal treatment apparatus Download PDF

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Publication number
WO2020220471A1
WO2020220471A1 PCT/CN2019/095110 CN2019095110W WO2020220471A1 WO 2020220471 A1 WO2020220471 A1 WO 2020220471A1 CN 2019095110 W CN2019095110 W CN 2019095110W WO 2020220471 A1 WO2020220471 A1 WO 2020220471A1
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light
imaging
assembly
endoscope
heating
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PCT/CN2019/095110
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French (fr)
Chinese (zh)
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程震
索永宽
刘弘光
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东北大学
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064Constructional details of the endoscope body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00131Accessories for endoscopes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163Optical arrangements
    • A61B1/00195Optical arrangements with eyepieces
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/07Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B2018/1807Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using light other than laser radiation

Definitions

  • the application belongs to the field of medical equipment, and specifically relates to a photothermal treatment device guided by endoscopic imaging.
  • endoscopes are difficult to operate. The reason is that the lengths of the various types of endoscopes used are different, and the various small accessories used for operation need to be controlled outside the body through the instrument channel of the endoscope, and the operation process Among them, the target tissue is in a state of motion, such as intestinal peristalsis, tracheal breathing, various sphincter spasm, etc., which require higher operating experience and level of the operating doctor. In minimally invasive endoscopy-related surgery, bleeding and oozing are more common.
  • the current endoscope hemostasis methods mainly include: spraying hemostatic drugs, injecting drugs to hemostasis, electrocoagulation hemostasis, photocoagulation hemostasis, argon hemostasis, microwave hemostasis, hemostasis clamp and other methods.
  • Each of these methods has advantages and disadvantages.
  • the principle of photocoagulation hemostasis is to irradiate local tissues to denature and coagulate proteins, and thrombosis in small blood vessels, so as to achieve the purpose of hemostasis.
  • Water and oxyhemoglobin have the best absorption rate for a certain wavelength of laser, so the corresponding wavelength of laser has an excellent coagulation and hemostasis effect.
  • the optical fiber reaches the lesion through the instrument channel of the endoscope. Under the guidance of the indicator light, the optical fiber is moved to a certain range from the target irradiation area, or directly touches the lesion and starts the laser emission , Perform hemostasis, cutting, ablation and other operations on the diseased tissue. Under the guidance of the endoscopic imaging of these operations, the surgeon activates the laser emission source to complete the relevant operations by indicating light positioning.
  • the current technology has the following limitations: 1) Manually operate the optical fiber, and the positioning accuracy is greatly dependent on the operator's experience and technology; 2) The indicating light guide positioning speed is slow, which is not conducive to multi-lesion irradiation and prolongs the operation Time; 3) Irradiation positioning is not accurate and limited to single-point irradiation; 4) The relative position of the optical fiber and the irradiated place must be kept fixed during irradiation, which is likely to cause position deviations for active tissues such as peristalsis and spasm; 5) Occupying instrument channel , Other operations cannot be performed at the same time.
  • This application provides a photothermal therapy device for endoscopic imaging guidance, which can solve one of the above technical problems.
  • This application provides a photothermal therapy device for endoscopic imaging guidance, including:
  • Endoscope components optical imaging components, projection components, heating light sources and control devices;
  • the optical imaging component is electrically connected with the control device by means of imaging equipment, and the projection component is electrically connected with the control device;
  • the endoscope assembly is used to transmit the light of the area to be analyzed to an optical imaging assembly, the optical imaging assembly images the light transmitted by the endoscope assembly, and the optical imaging assembly displays the resulting image by means of an imaging device In the control device;
  • the control device selects a part of the image to be heated according to the formed image, and controls the projection assembly according to the selected part of the image, so that the projection assembly returns the heating light of the heating light source along the imaging light path of the optical imaging assembly , And use the endoscope assembly to transmit the heating light to part or all of the area to be analyzed for heating treatment.
  • the endoscope assembly includes: a light source, a transmission fiber, and a hard endoscope assembly; the light source is connected to the hard endoscope assembly by means of the transmission fiber, and provides illumination light to the area to be analyzed;
  • a light source is connected to the fiber endoscope assembly by means of a transmission fiber, and provides illumination light to the area to be analyzed.
  • the hard endoscope assembly includes: an endoscope objective lens corresponding to the area to be analyzed, a fourth lens group connected to the endoscope objective lens for optical path transmission, and an endoscope connected to the fourth lens group eyepiece;
  • the fiber endoscope assembly includes: an endoscope objective lens corresponding to the area to be analyzed, an image transmission fiber connected to the endoscope objective lens for optical path transmission, and an endoscope eyepiece connected to the transmission fiber;
  • the endoscope eyepiece is connected with the optical path of the optical imaging component and the projection component.
  • the projection component includes: a liquid crystal screen made of high-transmittance high-temperature polysilicon connected to the control device or a digital light processing component connected to the control device.
  • the optical imaging component includes:
  • the first lens/first lens group for receiving visible light and invisible light of the area to be analyzed transmitted by the endoscope assembly
  • a spectroscopic element located on the imaging side of the first lens/first lens group that can transmit imaging light and reflect heating light;
  • a filter element located on the imaging side of the first lens/first lens group and filtering the transmitted light of the light splitting element
  • the third lens/third lens group for condensing the imaging light after passing through the filter element is the third lens/third lens group for condensing the imaging light after passing through the filter element
  • the second lens/second lens group located on the heating optical path for converging/diverging the light of the projection assembly to the light splitting element.
  • the optical imaging component includes:
  • a filter element that receives visible light and invisible light of the area to be analyzed transmitted by the endoscope assembly
  • the third lens/third lens group for condensing the imaging light after passing through the filter element is the third lens/third lens group for condensing the imaging light after passing through the filter element
  • the second lens/second lens group located on the heating optical path and used to converge/diverge the light of the projection assembly to the heating area of the object.
  • the device includes one or more sets of projection components and multiple heating light sources;
  • Each group of projection components corresponds to a heating light source.
  • the imaging device is one or more combinations of a visible light imaging camera, an invisible light imaging camera, and a thermal imaging camera.
  • the light source is a visible light source or an excitation light source or a fluorescent excitation light source.
  • it further includes a housing; the optical imaging component, the projection component, the heating light source and part of the endoscope component are all located in the housing, and the position in the housing conforms to the principle of optical imaging.
  • the device of the present application belongs to a new design of an endoscopic imaging system, which adds photo-thermal irradiation technology, and can controlly irradiate the target area in the field of view of the endoscope under the guidance of real-time imaging, and the target area can be controlled by the photo-thermal effect.
  • the temperature rises to achieve functions such as hemostasis and removal of target tissues.
  • the device of the present application can overcome the shortcomings of the prior art through the hardware design of the same optical path for imaging and heating light irradiation, and achieve more accurate simultaneous irradiation of multiple points and multiple areas, without being affected by human tissue activities, and capable of automatically tracking irradiation, and It does not occupy the instrument channel and can be performed simultaneously with other endoscope operations.
  • the device of the present application solves the problem of the controllability of heating light irradiation from the hardware.
  • the control device can display the imaging information (one or more combinations of visible light, near-infrared light and thermal imaging) in the field of view to the surgical operator, and with the help of the projection assembly, the heating light returns along part of the original optical path and is superimposed on The area to be analyzed.
  • the surgeon selects the point or area that needs to be heated, and makes the control device control the projection assembly to transmit the light with the specified power of the heating light source to the area to be analyzed to illuminate the area to be analyzed to complete hemostasis and other operations.
  • the heating light source is selectively shielded by adjusting the liquid crystal light valve or similar functional components in the projection assembly, so as to achieve selective illumination of a specific area in the field of view of the area to be analyzed.
  • an intelligent irradiation plan to achieve photothermal effects such as hemostasis.
  • a blue-green light source of about 500nm can be selected, which is easily absorbed by hemoglobin, which causes blood to coagulate and is suitable for hemostasis applications. And its output power is low, there is almost no photocoagulation effect on deep tissues, and hemostasis is safer.
  • the wavelength of the light source can be freely selected according to the needs of the application.
  • the wavelength of about 1000nm can also be selected according to the needs.
  • the hemoglobin absorbs poorly and penetrates deeply, which is suitable for coagulation of the tissue around the blood vessel and is also convenient for hemostasis.
  • This application can solve the controllability problem of endoscopic photothermal therapy.
  • the image acquired by the optical imaging component can selectively heat the target area to avoid damage to tissues and organs outside the target.
  • the liquid crystal light valve or similar functional components have strong maneuverability, the device can realize real-time, high-resolution and free control of the light intensity of the entire field of view of the therapeutic light. Used in conjunction with optical imaging and thermal imaging, real-time light adjustment can be achieved.
  • Photothermal therapy technology can follow the target in real time. This is because the illumination can be adjusted in real time according to the imaging, so that only the specified area in the image is illuminated. The realization of this function only needs to ensure that the illuminated target is always in the imaging field of view, and does not need to strictly fix the relative position of the illuminated object and the irradiation device, and ensures the safety of illumination.
  • control device of the present application can be combined with automatic image analysis technology to realize automatic identification, irradiation and hemostasis of microvascular bleeding.
  • the device of this application can be performed simultaneously with other endoscope operations. Since the device of the present application does not occupy the channel of the endoscopic instrument, it can be performed synchronously with other surgical operations, and hemostasis can be achieved as soon as the bleeding lesion is discovered.
  • This application solves the problem of uneven heating.
  • the uniform and controllable heating effect of the target area is achieved.
  • the irradiation is reduced, while the irradiation of the low temperature part is enhanced.
  • the target area meets the heating standard while ensuring that the non-target area is in a safe temperature range.
  • the selection of the photothermal light source is no longer restricted by the characteristic absorption spectrum of the photothermal enhancement material.
  • a light source of a specific wavelength has to be selected.
  • the light source is freely selected according to the characteristics of tissues and organs.
  • the photothermal heating light source with good directivity, high thermal efficiency and large penetration depth can be selected according to the needs.
  • the uniform and controllable heating effect of the target area is achieved.
  • the irradiation is reduced, while the irradiation of the low temperature part is enhanced.
  • the target area meets the heating standard while ensuring that the non-target area is in a safe temperature range.
  • optical path design schemes are adopted in this application. Both the shared optical path scheme can be used.
  • the foundation is laid, and light paths can also be set separately for imaging and heating light, so that multiple light sources can illuminate a target at the same time to achieve the effect of focusing on the target location.
  • the phototherapy in this application can follow the target in real time. This is because the illumination can be adjusted in real time according to the imaging, so that only the specified area in the image is illuminated.
  • the realization of this function only needs to ensure that the illuminated target is always in the imaging field of view, and it is not necessary to strictly fix the relative position of the illuminated object and the irradiation device. This brings great convenience to the implementation of photothermal therapy and ensures the safety of light.
  • FIG. 1 is a schematic structural diagram of a photothermal therapy device for endoscopic imaging guidance according to an embodiment of the application
  • FIG. 2 is a schematic structural diagram of a photothermal treatment device for endoscopic imaging guidance provided by another embodiment of the application;
  • FIG. 3 is a schematic structural diagram of a photothermal therapy device for endoscopic imaging guidance provided by another embodiment of the application;
  • Fig. 4 is a schematic structural diagram of a photothermal therapy device for endoscopic imaging guidance provided by another embodiment of the application.
  • the device of the present application can be applied to the fields of medical treatment, endoscopic physiotherapy, etc., including but not limited to the following applications: photocoagulation hemostasis: heating the target blood vessel to a specified temperature through real-time feedback imaging information to block it. Advantages: Avoid common side effects such as edema of surrounding tissues through precise heating. It can be used for various endoscope hemostasis, physical therapy and other purposes. For example, it can be used for precise physical therapy such as pain relief and wound healing, so that endoscopic physical therapy can be realized.
  • selective heating of the diseased tissue can be achieved to achieve the effect of resection or removal.
  • the device of the present application can realize optical imaging and thermal imaging of the target field of view. Based on optical imaging, select the area in the image that needs to be heated, and control the liquid crystal light valve or the DMD digital micro reflector (part of the DLP component) to transmit or reflect the treatment light. Then the light penetrates the transparent part of the liquid crystal light valve or is reflected by the DLP component to illuminate the diseased tissue. Thermal imaging monitors the temperature of the diseased tissue in real time, and adjusts the liquid crystal light valve and the treatment light according to the heating effect. The device of the present application can achieve a safe, stable and controllable heating effect for the treatment target.
  • the photothermal treatment device used for endoscopic imaging guidance of the present application includes:
  • Endoscope components optical imaging components, projection components, heating light sources and control devices;
  • the optical imaging component is electrically connected with the control device by means of imaging equipment, and the projection component is electrically connected with the control device;
  • the endoscope assembly is used to transmit the light of the area to be analyzed to the optical imaging assembly, the optical imaging assembly images the light transmitted by the endoscope assembly, and the optical imaging assembly displays the resulting image on the imaging device by means of the imaging device.
  • the control device In the control device;
  • the control device selects a part of the image to be heated according to the formed image, and controls the projection assembly according to the selected part of the image, so that the projection assembly returns the heating light of the heating light source along the imaging light path of the optical imaging assembly , And use the endoscope assembly to transmit the heating light to part or all of the area to be analyzed for heating treatment.
  • the endoscope assembly includes: a light source, a transmission fiber, and a hard endoscope assembly; the light source is connected to the hard endoscope assembly by means of the transmission fiber, and provides illumination light to the area to be analyzed.
  • the hard endoscope assembly in this embodiment may include: an endoscope objective lens corresponding to the area to be analyzed, and a fourth lens group connected to the endoscope objective lens for optical path transmission (not shown in the figure) Out), an endoscope eyepiece connected to the fourth lens group;
  • the endoscope eyepiece is connected to the optical path of the optical imaging component and the projection component.
  • the functional image beam in Figs. 1 and 2 is the connected optical path.
  • the endoscope assembly includes: a light source, a transmission fiber, and a fiber endoscope assembly; the light source is connected to the fiber endoscope assembly by means of the transmission fiber, and provides illumination light to the area to be analyzed.
  • the visible light source and the excitation light source are also components of the endoscope assembly.
  • the light sources in FIGS. 1 to 4 may be visible light sources or excitation light sources or fluorescent excitation light sources.
  • the fiber endoscope assembly includes: an endoscope objective lens corresponding to the area to be analyzed, an image transmission fiber connected to the endoscope objective lens for optical path transmission, and an endoscope eyepiece connected to the transmission fiber;
  • the optical path of the endoscope eyepiece and the optical imaging assembly and the projection assembly are docked.
  • the functional image beam in Figures 3 and 4 can be understood as the optical path of the docking.
  • the control device of this embodiment may be a computer, as shown in FIGS. 1 to 4 are all computers.
  • the control device is not limited in this embodiment, and can be configured according to actual needs.
  • Various image recognition and image processing programs can also be set in the control device of this embodiment to perform recognition processing on the image formed by the optical imaging component.
  • the projection assembly of this embodiment may include: a liquid crystal screen made of high-penetration high-temperature polysilicon connected to the control device (the high-temperature polysilicon liquid crystal screen shown in Figures 2 and 3) or a digital light connected to the control device Processing components (DLP components shown in Figure 1 and Figure 4).
  • optical imaging assembly is described as follows:
  • the optical imaging component of this embodiment may include: a first lens/first lens group for receiving visible light and invisible light of the area to be analyzed transmitted by the endoscope component;
  • a spectroscopic element located on the imaging side of the first lens/first lens group that can transmit imaging light and reflect heating light;
  • a filter element located on the imaging side of the first lens/first lens group and filtering the transmitted light of the light splitting element
  • the third lens/third lens group for condensing the imaging light after passing through the filter element is the third lens/third lens group for condensing the imaging light after passing through the filter element
  • the second lens/second lens group located on the heating optical path for converging/diverging the light of the projection assembly to the light splitting element.
  • the optical imaging component of this embodiment may include: a filter element that receives visible light and invisible light of the area to be analyzed transmitted by the endoscope component for filtering;
  • the third lens/third lens group for condensing the imaging light after passing through the filter element is the third lens/third lens group for condensing the imaging light after passing through the filter element
  • the second lens/second lens group located on the heating optical path and used to converge/diverge the light of the projection assembly to the heating area of the object.
  • each set of projection components there may be multiple sets of projection components, and there may be multiple heating light sources, and each set of projection components corresponds to a heating light source.
  • the imaging devices shown in FIGS. 1 to 4 may be one or more combinations of visible light imaging cameras, invisible light imaging cameras, and thermal imaging cameras.
  • the components shown in FIGS. 1 to 4 are all located in the housing, that is, the device of this embodiment may further include a housing, and the optical imaging assembly, projection assembly, heating light source and part of the endoscope assembly are all located in the housing, and The position in the housing conforms to the principle of optical imaging.
  • the above device can achieve a safe, stable and controllable heating effect for the treatment target:
  • the excitation light source and the visible light source irradiate the treated tissue through the beam splitting fiber and the endoscope light source path and divergent lens,
  • the reflected light/emitted fluorescence contrast between the diseased area and the normal tissue is generated.
  • This image passes through the endoscope objective lens and the image transmission optical path (the lens in the hard mirror Group, in the fiberscope, it is the image transmission fiber), which is transmitted to the optical imaging assembly through the endoscope eyepiece lens, and is transmitted to the imaging unit of the functional imaging camera (ie imaging device) through the splitting element and filter element in the optical imaging assembly.
  • the light element blocks the excitation light source and transmits the functional image beam.
  • the camera transmits the image signal to the computer, and the computer performs image display, storage and analysis (analysis can be realized automatically or manually), and the analysis result is used to control the liquid crystal light valve or digital light processing (Digital Light Processing, DLP) components.
  • the liquid crystal light valve is made of High Temperature Poly-Silicon (HTPS).
  • HTPS High Temperature Poly-Silicon
  • the image analysis control signal transmitted from the computer controls the transparent area of the liquid crystal light valve and heats the light source.
  • only the light in the transparent area can pass through the liquid crystal light valve, and be transmitted to the endoscope eyepiece through the lens group and light splitting element, and then irradiate the diseased area through the endoscope image transmission optical path and the endoscope objective lens to achieve Precise photothermal therapy guided by imaging.
  • the image signal of the computer is transmitted to the DLP controller, and the high-resolution digital micromirror (DMD) in the DLP component receives the signal from the DLP controller and changes the angle of the micromirror to achieve functional image control
  • DMD digital micromirror
  • the light reflection, the reflected light of the treatment light is irradiated on the diseased area through the lens group and the light splitting element, to realize the precise photothermal treatment controlled by the functional image.
  • Thermal imaging monitors the temperature of the diseased tissue in real time, and adjusts the liquid crystal light valve or DMD digital micro reflector and the treatment light according to the heating effect.
  • the heating light/irradiating light of the heating light source is reflected by the DLP component, and shares part of the optical path with the optical imaging component, and cooperates with a hard endoscope to realize imaging and thermal therapy.
  • the heating light/irradiation light of the heating light source is projected through the HTPS liquid crystal screen, and shares part of the optical path with the optical imaging component, and cooperates with the hard endoscope to achieve imaging and thermal therapy.
  • the liquid crystal light valve is made of High Temperature Poly-Silicon (HTPS).
  • HTPS High Temperature Poly-Silicon
  • the image analysis control signal transmitted from the computer controls the transparent area of the liquid crystal light valve.
  • the heating light source irradiates the liquid crystal light valve, only the transparent area The light can pass through the liquid crystal light valve, irradiate the diseased area through the lens group, the light splitting element, and the endoscope assembly, so as to achieve imaging-guided precise photothermal treatment.
  • the heating light/irradiating light of the heating light source is projected through the HTPS liquid crystal screen, and shares part of the optical path with the optical imaging component, and cooperates with the fiber endoscope to realize imaging and thermal therapy.
  • the heating light/irradiating light of the heating light source is reflected by the DLP component, and shares part of the optical path with the optical imaging component, and cooperates with the fiber endoscope to realize imaging and thermal therapy.
  • the projection component is different.
  • the projection component of this embodiment is a digital light processing (DLP) component connected to the control device.
  • DLP digital light processing
  • the image signal of the computer/control device is transmitted to the DLP controller.
  • the high-resolution digital micromirror (DMD) in the DLP component receives the signal from the DLP controller and changes the angle of the micromirror in the DLP component to achieve light reflection controlled by the functional image ,
  • the reflected light of the heating light is connected to the endoscope assembly through the lens group and the light splitting element to achieve precise photothermal treatment.
  • the imaging of the optical imaging component may be visible light imaging of the area to be analyzed, or invisible light imaging of the area to be analyzed, which is not limited in this embodiment and is adjusted according to actual needs.
  • the structures of the foregoing embodiments realize optical imaging and thermal imaging of the target field of view, and realize precise control of the therapeutic light.
  • the photothermal therapy device of the present application includes: an endoscope assembly, an optical imaging assembly, a projection assembly, a heating light source, a control device, etc.
  • the photothermal therapy device with the above structure can follow the target in real time during phototherapy, and realize the irradiation of a designated area , To ensure the imaging of the illuminated target. Therefore, it has industrial applicability.

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Abstract

An endoscopic imaging-guided photothermal treatment apparatus, comprising: an endoscope assembly, an optical imaging assembly, a projection assembly, a heating light source, and a control device. The optical imaging assembly is electrically connected to the control device by means of an imaging device. The endoscope assembly is used for transmitting light of areas to be analyzed to the optical imaging assembly. The optical imaging assembly performs imaging on the light transmitted by the endoscope assembly, and displays the formed images in the control device by means of the imaging device. The control device selects some images to be heated according to the formed images, and controls the projection assembly according to the selected images, such that the projection assembly returns heating light of the heating light source back along an imaging light path of the optical imaging assembly and transmits the heating light to some or all of the areas to be analyzed by means of the endoscope assembly, thereby performing heating treatment. The photothermal treatment apparatus resolves the problem of controllability of endoscopic lighting and heating, does not occupy an existing designed instrument channel, and features safe use and low costs.

Description

一种内窥成像指导的光热治疗装置Photothermal therapy device guided by endoscopic imaging 技术领域Technical field
本申请属于医学器械领域,具体涉及一种内窥成像指导的光热治疗装置。The application belongs to the field of medical equipment, and specifically relates to a photothermal treatment device guided by endoscopic imaging.
背景技术Background technique
各类内窥镜的操作难度较大,其原因是所使用的各型内窥镜长度不一,用于操作的各种小附件均需通过内窥镜的器械通道在体外控制、且操作过程中有目标组织处于运动状态,例如肠道蠕动、气管呼吸、各类括约肌痉挛等情况,对操作医生的操作经验和水平要求较高。在内窥镜相关的微创手术中,出血和渗血较为常见。目前的内窥镜止血方法主要有:喷洒止血药,注射药物止血,电凝止血,光凝止血,氩气止血,微波止血,止血夹等方法。这些方法各有利弊。其中,光凝止血的原理是照射局部组织,使其蛋白变性凝固,小血管内血栓形成,从而达到止血的目的。水及氧合血红蛋白对一定波长的激光具有最佳吸收率,因此相应波长的激光具有极佳的凝固止血效果。Various types of endoscopes are difficult to operate. The reason is that the lengths of the various types of endoscopes used are different, and the various small accessories used for operation need to be controlled outside the body through the instrument channel of the endoscope, and the operation process Among them, the target tissue is in a state of motion, such as intestinal peristalsis, tracheal breathing, various sphincter spasm, etc., which require higher operating experience and level of the operating doctor. In minimally invasive endoscopy-related surgery, bleeding and oozing are more common. The current endoscope hemostasis methods mainly include: spraying hemostatic drugs, injecting drugs to hemostasis, electrocoagulation hemostasis, photocoagulation hemostasis, argon hemostasis, microwave hemostasis, hemostasis clamp and other methods. Each of these methods has advantages and disadvantages. Among them, the principle of photocoagulation hemostasis is to irradiate local tissues to denature and coagulate proteins, and thrombosis in small blood vessels, so as to achieve the purpose of hemostasis. Water and oxyhemoglobin have the best absorption rate for a certain wavelength of laser, so the corresponding wavelength of laser has an excellent coagulation and hemostasis effect.
在目前的内窥镜光凝止血应用中,光纤通过内窥镜的器械通道到达病灶,在指示光的引导下,将光纤移动到距离目标照射区域一定范围内,或直接接触病灶,启动激光发射,对病变组织进行止血、切割、消融等操作。这些操作在内窥镜成像的引导下,术者通过指示光定位,启动激光发射源,完成相关操作。In the current endoscope photocoagulation hemostasis application, the optical fiber reaches the lesion through the instrument channel of the endoscope. Under the guidance of the indicator light, the optical fiber is moved to a certain range from the target irradiation area, or directly touches the lesion and starts the laser emission , Perform hemostasis, cutting, ablation and other operations on the diseased tissue. Under the guidance of the endoscopic imaging of these operations, the surgeon activates the laser emission source to complete the relevant operations by indicating light positioning.
目前的技术具有以下局限性:1)手动操作光纤,定位的准确度对操作者的经验和技术有较大的依赖性;2)指示光引导定位速度慢,不利于多病灶照射,延长了手术时间;3)照射定位不精确,仅限于单点照射;4)照射时必须保持光纤与被照射处相对位置固定,对于蠕动、痉挛等活动的组织,容易造成位置偏差;5)占位器械通道,无法同时进行其他操 作。The current technology has the following limitations: 1) Manually operate the optical fiber, and the positioning accuracy is greatly dependent on the operator's experience and technology; 2) The indicating light guide positioning speed is slow, which is not conducive to multi-lesion irradiation and prolongs the operation Time; 3) Irradiation positioning is not accurate and limited to single-point irradiation; 4) The relative position of the optical fiber and the irradiated place must be kept fixed during irradiation, which is likely to cause position deviations for active tissues such as peristalsis and spasm; 5) Occupying instrument channel , Other operations cannot be performed at the same time.
发明内容Summary of the invention
本申请提供一种用于内窥成像指导的光热治疗装置,能够解决上述技术问题之一。This application provides a photothermal therapy device for endoscopic imaging guidance, which can solve one of the above technical problems.
为了达到上述的目的,本申请采用的主要技术方案如下。In order to achieve the above objectives, the main technical solutions adopted in this application are as follows.
本申请提供一种用于内窥成像指导的光热治疗装置,包括:This application provides a photothermal therapy device for endoscopic imaging guidance, including:
内窥镜组件、光学成像组件、投影组件、加热光源和控制装置;Endoscope components, optical imaging components, projection components, heating light sources and control devices;
所述光学成像组件借助于成像设备与控制装置电连接,所述投影组件与所述控制装置电连接;The optical imaging component is electrically connected with the control device by means of imaging equipment, and the projection component is electrically connected with the control device;
所述内窥镜组件用于将待分析区域的光传输至光学成像组件,所述光学成像组件将内窥镜组件传输的光进行成像,所述光学成像组件借助于成像设备将所成图像显示在所述控制装置中;The endoscope assembly is used to transmit the light of the area to be analyzed to an optical imaging assembly, the optical imaging assembly images the light transmitted by the endoscope assembly, and the optical imaging assembly displays the resulting image by means of an imaging device In the control device;
所述控制装置依据所成图像选择部分需要加热的部分图像,并依据选择的部分图像控制所述投影组件,使得投影组件将加热光源的加热光沿着所述光学成像组件的成像光路原路返回,以及借助于内窥镜组件将加热光传输至待分析区域中的部分或全部,以进行加热处理。The control device selects a part of the image to be heated according to the formed image, and controls the projection assembly according to the selected part of the image, so that the projection assembly returns the heating light of the heating light source along the imaging light path of the optical imaging assembly , And use the endoscope assembly to transmit the heating light to part or all of the area to be analyzed for heating treatment.
可选地,内窥镜组件包括:光源、传输光纤、硬内窥镜组件;所述光源借助于传输光纤与硬内窥镜组件连接,并向待分析区域提供照射光;Optionally, the endoscope assembly includes: a light source, a transmission fiber, and a hard endoscope assembly; the light source is connected to the hard endoscope assembly by means of the transmission fiber, and provides illumination light to the area to be analyzed;
或者,光源、传输光纤、纤维内窥镜组件;所述光源借助于传输光纤与纤维内窥镜组件连接,并向待分析区域提供照射光。Or, a light source, a transmission fiber, and a fiber endoscope assembly; the light source is connected to the fiber endoscope assembly by means of a transmission fiber, and provides illumination light to the area to be analyzed.
可选地,硬内窥镜组件包括:对应待分析区域的内窥镜物镜、与所述内窥镜物镜连接的进行光路传输的第四透镜组,与该第四透镜组连接的内窥镜目镜;Optionally, the hard endoscope assembly includes: an endoscope objective lens corresponding to the area to be analyzed, a fourth lens group connected to the endoscope objective lens for optical path transmission, and an endoscope connected to the fourth lens group eyepiece;
纤维内窥镜组件包括:对应待分析区域的内窥镜物镜、与所述内窥镜物镜连接的进行光路传输的传像光纤、与该传输光纤连接的内窥镜目镜;The fiber endoscope assembly includes: an endoscope objective lens corresponding to the area to be analyzed, an image transmission fiber connected to the endoscope objective lens for optical path transmission, and an endoscope eyepiece connected to the transmission fiber;
所述内窥镜目镜与所述光学成像组件、投影组件的光路对接。The endoscope eyepiece is connected with the optical path of the optical imaging component and the projection component.
可选地,所述投影组件包括:与所述控制装置连接的采用高穿透式高温多晶硅制作的液晶屏或与控制装置连接的数字光处理组件。Optionally, the projection component includes: a liquid crystal screen made of high-transmittance high-temperature polysilicon connected to the control device or a digital light processing component connected to the control device.
可选地,所述光学成像组件包括:Optionally, the optical imaging component includes:
接收内窥镜组件传输的待分析区域的可见光和不可见光的第一透镜/第一透镜组;The first lens/first lens group for receiving visible light and invisible light of the area to be analyzed transmitted by the endoscope assembly;
位于第一透镜/第一透镜组的成像侧的能够透射成像光线并反射加热光的分光元件;A spectroscopic element located on the imaging side of the first lens/first lens group that can transmit imaging light and reflect heating light;
位于第一透镜/第一透镜组的成像侧的,且对分光元件的透射光进行滤光的滤光元件;A filter element located on the imaging side of the first lens/first lens group and filtering the transmitted light of the light splitting element;
用于对经由滤光元件后的成像光进行汇聚的第三透镜/第三透镜组;The third lens/third lens group for condensing the imaging light after passing through the filter element;
位于加热光路上的用于将投影组件的光进行汇聚/发散至分光元件的第二透镜/第二透镜组。The second lens/second lens group located on the heating optical path for converging/diverging the light of the projection assembly to the light splitting element.
可选地,所述光学成像组件包括:Optionally, the optical imaging component includes:
接收内窥镜组件传输的待分析区域的可见光和不可见光进行滤光的滤光元件;A filter element that receives visible light and invisible light of the area to be analyzed transmitted by the endoscope assembly;
用于对经由滤光元件后的成像光进行汇聚的第三透镜/第三透镜组;The third lens/third lens group for condensing the imaging light after passing through the filter element;
位于加热光路上的用于将投影组件的光进行汇聚/发散至物体加热区域的第二透镜/第二透镜组。The second lens/second lens group located on the heating optical path and used to converge/diverge the light of the projection assembly to the heating area of the object.
可选地,所述装置包括一组或多组投影组件和多个加热光源;Optionally, the device includes one or more sets of projection components and multiple heating light sources;
每一组投影组件对应一加热光源。Each group of projection components corresponds to a heating light source.
可选地,所述成像设备为可见光成像相机、不可见光成像相机和热成像相机中的一种或多种组合。Optionally, the imaging device is one or more combinations of a visible light imaging camera, an invisible light imaging camera, and a thermal imaging camera.
可选地,所述光源为可见光光源或激发光源或荧光激发光源。Optionally, the light source is a visible light source or an excitation light source or a fluorescent excitation light source.
可选地,还包括外壳;所述光学成像组件、投影组件、加热光源和部分内窥镜组件均位于壳体内,且在壳体内的位置符合光学成像原理。Optionally, it further includes a housing; the optical imaging component, the projection component, the heating light source and part of the endoscope component are all located in the housing, and the position in the housing conforms to the principle of optical imaging.
本申请的有益效果是:The beneficial effects of this application are:
本申请的装置属于内窥镜成像系统的新设计,增加了光热照射技术,能够在实时成像的指导下,对内窥镜视野内的目标区域进行可控照射, 通过光热效应使目标区域的温度升高,实现止血和清除目标组织等功能。The device of the present application belongs to a new design of an endoscopic imaging system, which adds photo-thermal irradiation technology, and can controlly irradiate the target area in the field of view of the endoscope under the guidance of real-time imaging, and the target area can be controlled by the photo-thermal effect. The temperature rises to achieve functions such as hemostasis and removal of target tissues.
本申请的装置通过成像与加热光照射的同光路硬件设计,能够克服现有技术的缺点,实现更精准的多点、多区域同时照射,不受人体组织活动的影响,能够自动追踪照射,且不占用器械通道,可以与其他内窥镜操作同时进行。The device of the present application can overcome the shortcomings of the prior art through the hardware design of the same optical path for imaging and heating light irradiation, and achieve more accurate simultaneous irradiation of multiple points and multiple areas, without being affected by human tissue activities, and capable of automatically tracking irradiation, and It does not occupy the instrument channel and can be performed simultaneously with other endoscope operations.
进一步地,本申请的装置从硬件上解决了加热光照射的可控性问题。控制装置能够将视野中的成像信息(可见光、近红外光和热成像中的一种或多种组合)展示给手术操作者,并借助于投影组件使得加热光沿着部分原光路返回并叠加在待分析区域。Furthermore, the device of the present application solves the problem of the controllability of heating light irradiation from the hardware. The control device can display the imaging information (one or more combinations of visible light, near-infrared light and thermal imaging) in the field of view to the surgical operator, and with the help of the projection assembly, the heating light returns along part of the original optical path and is superimposed on The area to be analyzed.
手术操作者根据控制装置展示的成像图像,进而选择需要加热的点或区域,并使得控制装置控制投影组件将加热光源指定功率的光传输待分析区域进行照射,完成止血等操作。According to the imaging image displayed by the control device, the surgeon selects the point or area that needs to be heated, and makes the control device control the projection assembly to transmit the light with the specified power of the heating light source to the area to be analyzed to illuminate the area to be analyzed to complete hemostasis and other operations.
也就是说,在使用中,通过调整投影组件中的液晶光阀或类似功能组件对加热光源进行选择性遮挡,从而实现对待分析区域的视野中特定区域的选择性照射。可选地,结合自动化图像分析技术,制定智能的照射方案,达到止血等光热效果。在止血应用中,可以选择500nm左右的蓝绿光源,容易被血红蛋白吸收,是血液产生凝固,适宜止血应用。且其输出功率低,对深部组织几乎无光凝作用,止血更安全。That is to say, during use, the heating light source is selectively shielded by adjusting the liquid crystal light valve or similar functional components in the projection assembly, so as to achieve selective illumination of a specific area in the field of view of the area to be analyzed. Optionally, combined with automated image analysis technology, formulate an intelligent irradiation plan to achieve photothermal effects such as hemostasis. In the application of hemostasis, a blue-green light source of about 500nm can be selected, which is easily absorbed by hemoglobin, which causes blood to coagulate and is suitable for hemostasis applications. And its output power is low, there is almost no photocoagulation effect on deep tissues, and hemostasis is safer.
前述装置在应用中,可根据应用的需要自由选择光源的波长。也可以根据需要选择1000nm左右的波长,血红蛋白对其吸收差,穿透深度较深,适合对血管周围组织产生凝固作用,也便于止血。In the application of the aforementioned device, the wavelength of the light source can be freely selected according to the needs of the application. The wavelength of about 1000nm can also be selected according to the needs. The hemoglobin absorbs poorly and penetrates deeply, which is suitable for coagulation of the tissue around the blood vessel and is also convenient for hemostasis.
为更好的理解本申请装置的优势或应用中的优势,以下进行说明:In order to better understand the advantages of the device of this application or the advantages in the application, the following is an explanation:
1、本申请可以解决内窥光热治疗的可控性难题。通过光学成像组件获取的图像,实现选择性地对目标区域加热,避免对目标以外组织和器官的损伤。由于液晶光阀或类似功能组件具有较强的可操控性,本装置能够实现治疗光的实时、高分辨率和全视野范围的光强自由调控。与光学成像和热成像配合使用,能够做到实时的光照调整。1. This application can solve the controllability problem of endoscopic photothermal therapy. The image acquired by the optical imaging component can selectively heat the target area to avoid damage to tissues and organs outside the target. Because the liquid crystal light valve or similar functional components have strong maneuverability, the device can realize real-time, high-resolution and free control of the light intensity of the entire field of view of the therapeutic light. Used in conjunction with optical imaging and thermal imaging, real-time light adjustment can be achieved.
2、本申请解决了跟踪定位难题。光热治疗技术能够实时跟随目标。 这是因为光照能够根据成像进行实时调整,实现只对图像中的指定区域照射。该功能的实现只需保证被照射目标始终处于成像视野即可,不需要严格固定被照射对象与照射装置的相对位置,并确保了光照的安全性。2. This application solves the problem of tracking and positioning. Photothermal therapy technology can follow the target in real time. This is because the illumination can be adjusted in real time according to the imaging, so that only the specified area in the image is illuminated. The realization of this function only needs to ensure that the illuminated target is always in the imaging field of view, and does not need to strictly fix the relative position of the illuminated object and the irradiation device, and ensures the safety of illumination.
3、本申请的控制装置可结合自动化图像分析技术,实现对微小血管出血的自动识别、照射和止血。3. The control device of the present application can be combined with automatic image analysis technology to realize automatic identification, irradiation and hemostasis of microvascular bleeding.
4、本申请的装置可与其他内窥镜操作同时进行。由于本申请的装置不占用内窥镜器械通道,可以与其他手术操作同步进行,在发现出血灶的第一时间实现止血。4. The device of this application can be performed simultaneously with other endoscope operations. Since the device of the present application does not occupy the channel of the endoscopic instrument, it can be performed synchronously with other surgical operations, and hemostasis can be achieved as soon as the bleeding lesion is discovered.
5、本申请解决加热不均匀问题。通过实时光学和热成像分析,实现目标区域均匀可控的加热效果。对于目标区域的高温部分减少照射,同时增强低温部分的照射。通过成像的实时反馈,实现目标区域符合加热标准,同时保障非目标区域处于安全温度范围。5. This application solves the problem of uneven heating. Through real-time optical and thermal imaging analysis, the uniform and controllable heating effect of the target area is achieved. For the high temperature part of the target area, the irradiation is reduced, while the irradiation of the low temperature part is enhanced. Through the real-time feedback of imaging, the target area meets the heating standard while ensuring that the non-target area is in a safe temperature range.
6、应用病变区域的治疗时不再需要光热增强物质。利用光学方法实现病变的靶向光热治疗,使光热治疗方法不再依赖光热增强物质,避免了光热增强物质导致的毒副作用。6. Light and heat enhancing substances are no longer needed when applying the treatment of the diseased area. The use of optical methods to achieve targeted photothermal treatment of lesions makes the photothermal treatment method no longer rely on photothermal enhancement substances, and avoids the toxic and side effects caused by photothermal enhancement substances.
本申请中由于不需要光热增强物质,进而光热的光源选择不再受到光热增强物质特征吸收光谱的制约。在现有技术中,由于不同物质具有其特征吸收光谱,使用光热增强物质的光热照射时,不得不选择特定波长的光源。本申请则根据组织和器官的特性自由选择光源。可以根据需要选择指向性好、热效率高、穿透深度大的光热加热光源。Since the photothermal enhancement material is not required in this application, the selection of the photothermal light source is no longer restricted by the characteristic absorption spectrum of the photothermal enhancement material. In the prior art, since different substances have their own characteristic absorption spectra, when using photothermal enhancement substances for photothermal irradiation, a light source of a specific wavelength has to be selected. In this application, the light source is freely selected according to the characteristics of tissues and organs. The photothermal heating light source with good directivity, high thermal efficiency and large penetration depth can be selected according to the needs.
解决光热治疗/照射中加热不均匀问题。通过实时光学和热成像分析,实现目标区域均匀可控的加热效果。对于目标区域的高温部分减少照射,同时增强低温部分的照射。通过成像的实时反馈,使目标区域符合加热标准,同时保障非目标区域处于安全温度范围。Solve the problem of uneven heating in photothermal treatment/irradiation. Through real-time optical and thermal imaging analysis, the uniform and controllable heating effect of the target area is achieved. For the high temperature part of the target area, the irradiation is reduced, while the irradiation of the low temperature part is enhanced. Through the real-time feedback of imaging, the target area meets the heating standard while ensuring that the non-target area is in a safe temperature range.
此外,本申请中采用多种光路设计方案,既可以采用共享光路方案,加热光照射光路与成像光路重合,从硬件上解决了两者的精准对位难题,为精准光热治疗/照射的实现奠定了基础,也可以为成像与加热光分别设置光路,以便于多光源同时照射一个目标,在目标部位达到聚焦照射的 效果。In addition, a variety of optical path design schemes are adopted in this application. Both the shared optical path scheme can be used. The heating light irradiation optical path and the imaging optical path overlap, which solves the problem of precise alignment of the two from the hardware, and is the realization of precise photothermal treatment/irradiation. The foundation is laid, and light paths can also be set separately for imaging and heating light, so that multiple light sources can illuminate a target at the same time to achieve the effect of focusing on the target location.
本申请中的光照治疗能够实时跟随目标。这是因为光照能够根据成像进行实时调整,实现只对图像中的指定区域照射。该功能的实现只需保证被照射目标始终处于成像视野即可,不需要严格固定被照射对象与照射装置的相对位置。这为光热治疗的实施带来了极大的方便,并确保了光照的安全性。The phototherapy in this application can follow the target in real time. This is because the illumination can be adjusted in real time according to the imaging, so that only the specified area in the image is illuminated. The realization of this function only needs to ensure that the illuminated target is always in the imaging field of view, and it is not necessary to strictly fix the relative position of the illuminated object and the irradiation device. This brings great convenience to the implementation of photothermal therapy and ensures the safety of light.
附图说明Description of the drawings
图1为本申请一实施例提供的一种用于内窥成像指导的光热治疗装置的结构示意图;FIG. 1 is a schematic structural diagram of a photothermal therapy device for endoscopic imaging guidance according to an embodiment of the application;
图2为申请另一实施例提供的一种用于内窥成像指导的光热治疗装置的结构示意图;2 is a schematic structural diagram of a photothermal treatment device for endoscopic imaging guidance provided by another embodiment of the application;
图3为申请另一实施例提供的一种用于内窥成像指导的光热治疗装置的结构示意图;3 is a schematic structural diagram of a photothermal therapy device for endoscopic imaging guidance provided by another embodiment of the application;
图4为申请另一实施例提供的一种用于内窥成像指导的光热治疗装置的结构示意图。Fig. 4 is a schematic structural diagram of a photothermal therapy device for endoscopic imaging guidance provided by another embodiment of the application.
具体实施方式Detailed ways
为了更好地解释本申请,以便于理解,下面结合附图,通过具体实施方式,对本申请作详细描述。In order to better explain the application and facilitate understanding, the application will be described in detail below with reference to the drawings and through specific implementations.
本申请的装置可应用于医疗、内窥镜理疗等领域,包括但不限于以下应用:光凝止血:通过实时反馈的成像信息对目标血管加热到指定温度使其闭锁。优势:通过精准的加热避免周围组织水肿等常见副作用。可用于各种内窥镜止血、理疗等用途,例如可用于祛痛、加速伤口愈合等精准理疗,使内窥镜理疗得以实现。The device of the present application can be applied to the fields of medical treatment, endoscopic physiotherapy, etc., including but not limited to the following applications: photocoagulation hemostasis: heating the target blood vessel to a specified temperature through real-time feedback imaging information to block it. Advantages: Avoid common side effects such as edema of surrounding tissues through precise heating. It can be used for various endoscope hemostasis, physical therapy and other purposes. For example, it can be used for precise physical therapy such as pain relief and wound healing, so that endoscopic physical therapy can be realized.
此外,还可实现对病变组织的选择性加热,实现切除或清除的效果。In addition, selective heating of the diseased tissue can be achieved to achieve the effect of resection or removal.
本申请的装置能够实现对目标视野进行光学成像和热成像。基于光学成像,选择图像中需要加热的区域,控制液晶光阀或者DMD数字微反 射器(DLP组件的一部分),产生对治疗光的透过或反射。进而光穿透液晶光阀中的透明部分,或者通过DLP组件反射,照射于病变组织。热成像实时监控病变组织的温度,根据加热效果调整液晶光阀和治疗光。本申请的装置能够实现对治疗目标的安全、稳定和可控的加热效果。The device of the present application can realize optical imaging and thermal imaging of the target field of view. Based on optical imaging, select the area in the image that needs to be heated, and control the liquid crystal light valve or the DMD digital micro reflector (part of the DLP component) to transmit or reflect the treatment light. Then the light penetrates the transparent part of the liquid crystal light valve or is reflected by the DLP component to illuminate the diseased tissue. Thermal imaging monitors the temperature of the diseased tissue in real time, and adjusts the liquid crystal light valve and the treatment light according to the heating effect. The device of the present application can achieve a safe, stable and controllable heating effect for the treatment target.
为更好的理解本实施例的装置,以下结合图1至图4对本申请的装置进行详细说明。In order to better understand the device of this embodiment, the device of the present application will be described in detail below with reference to FIGS. 1 to 4.
本申请的用于内窥成像指导的光热治疗装置,包括:The photothermal treatment device used for endoscopic imaging guidance of the present application includes:
内窥镜组件、光学成像组件、投影组件、加热光源和控制装置;Endoscope components, optical imaging components, projection components, heating light sources and control devices;
其中,光学成像组件借助于成像设备与控制装置电连接,所述投影组件与所述控制装置电连接;Wherein, the optical imaging component is electrically connected with the control device by means of imaging equipment, and the projection component is electrically connected with the control device;
内窥镜组件用于将待分析区域的光传输至光学成像组件,所述光学成像组件将内窥镜组件传输的光进行成像,所述光学成像组件借助于成像设备将所成图像显示在所述控制装置中;The endoscope assembly is used to transmit the light of the area to be analyzed to the optical imaging assembly, the optical imaging assembly images the light transmitted by the endoscope assembly, and the optical imaging assembly displays the resulting image on the imaging device by means of the imaging device. In the control device;
所述控制装置依据所成图像选择部分需要加热的部分图像,并依据选择的部分图像控制所述投影组件,使得投影组件将加热光源的加热光沿着所述光学成像组件的成像光路原路返回,以及借助于内窥镜组件将加热光传输至待分析区域中部分或全部,以进行加热处理。The control device selects a part of the image to be heated according to the formed image, and controls the projection assembly according to the selected part of the image, so that the projection assembly returns the heating light of the heating light source along the imaging light path of the optical imaging assembly , And use the endoscope assembly to transmit the heating light to part or all of the area to be analyzed for heating treatment.
如图1至图2所示,内窥镜组件包括:光源、传输光纤、硬内窥镜组件;所述光源借助于传输光纤与硬内窥镜组件连接,并向待分析区域提供照射光。As shown in Figures 1 to 2, the endoscope assembly includes: a light source, a transmission fiber, and a hard endoscope assembly; the light source is connected to the hard endoscope assembly by means of the transmission fiber, and provides illumination light to the area to be analyzed.
可理解的是,本实施例中的硬内窥镜组件可包括:对应待分析区域的内窥镜物镜、与所述内窥镜物镜连接的进行光路传输的第四透镜组(图中未示出),与该第四透镜组连接的内窥镜目镜;It is understandable that the hard endoscope assembly in this embodiment may include: an endoscope objective lens corresponding to the area to be analyzed, and a fourth lens group connected to the endoscope objective lens for optical path transmission (not shown in the figure) Out), an endoscope eyepiece connected to the fourth lens group;
所述内窥镜目镜与所述光学成像组件、投影组件的光路对接,如图1和图2中的功能图像光束即为对接的光路。The endoscope eyepiece is connected to the optical path of the optical imaging component and the projection component. The functional image beam in Figs. 1 and 2 is the connected optical path.
如图3和图4所示,内窥镜组件包括:光源、传输光纤、纤维内窥镜组件;所述光源借助于传输光纤与纤维内窥镜组件连接,并向待分析 区域提供照射光。As shown in Figures 3 and 4, the endoscope assembly includes: a light source, a transmission fiber, and a fiber endoscope assembly; the light source is connected to the fiber endoscope assembly by means of the transmission fiber, and provides illumination light to the area to be analyzed.
另外,参照图3和图4所示,可见光光源和激发光源也都属于内窥镜组件的部件。In addition, referring to FIGS. 3 and 4, the visible light source and the excitation light source are also components of the endoscope assembly.
应说明的是,图1至图4中的光源可为可见光光源或激发光源或荧光激发光源。It should be noted that the light sources in FIGS. 1 to 4 may be visible light sources or excitation light sources or fluorescent excitation light sources.
纤维内窥镜组件包括:对应待分析区域的内窥镜物镜、与所述内窥镜物镜连接的进行光路传输的传像光纤、与该传输光纤连接的内窥镜目镜;The fiber endoscope assembly includes: an endoscope objective lens corresponding to the area to be analyzed, an image transmission fiber connected to the endoscope objective lens for optical path transmission, and an endoscope eyepiece connected to the transmission fiber;
所述内窥镜目镜与所述光学成像组件、投影组件的光路对接,如图3和图4中的功能图像光束,即可理解为对接的光路。The optical path of the endoscope eyepiece and the optical imaging assembly and the projection assembly are docked. The functional image beam in Figures 3 and 4 can be understood as the optical path of the docking.
本实施例的控制装置可为计算机,如图1至图4所示的均为计算机,当然,本实施例中不限定控制装置,可根据实际需求配置。本实施例的控制装置中还可设置各种图像识别和图像处理的程序,以便对光学成像组件成像的图像进行识别处理。The control device of this embodiment may be a computer, as shown in FIGS. 1 to 4 are all computers. Of course, the control device is not limited in this embodiment, and can be configured according to actual needs. Various image recognition and image processing programs can also be set in the control device of this embodiment to perform recognition processing on the image formed by the optical imaging component.
本实施例的投影组件可包括:与所述控制装置连接的采用高穿透式高温多晶硅制作的液晶屏(如图2、图3所示的高温多晶硅液晶屏)或与控制装置连接的数字光处理组件(如图1、图4所示的DLP组件)。The projection assembly of this embodiment may include: a liquid crystal screen made of high-penetration high-temperature polysilicon connected to the control device (the high-temperature polysilicon liquid crystal screen shown in Figures 2 and 3) or a digital light connected to the control device Processing components (DLP components shown in Figure 1 and Figure 4).
为了更好的理解本实施例的光路,对光学成像组件说明如下:In order to better understand the optical path of this embodiment, the optical imaging assembly is described as follows:
如图1、图3和图4所示,本实施例的光学成像组件可包括:接收内窥镜组件传输的待分析区域的可见光和不可见光的第一透镜/第一透镜组;As shown in FIGS. 1, 3, and 4, the optical imaging component of this embodiment may include: a first lens/first lens group for receiving visible light and invisible light of the area to be analyzed transmitted by the endoscope component;
位于第一透镜/第一透镜组的成像侧的能够透射成像光线并反射加热光的分光元件;A spectroscopic element located on the imaging side of the first lens/first lens group that can transmit imaging light and reflect heating light;
位于第一透镜/第一透镜组的成像侧的,且对分光元件的透射光进行滤光的滤光元件;A filter element located on the imaging side of the first lens/first lens group and filtering the transmitted light of the light splitting element;
用于对经由滤光元件后的成像光进行汇聚的第三透镜/第三透镜组;The third lens/third lens group for condensing the imaging light after passing through the filter element;
位于加热光路上的用于将投影组件的光进行汇聚/发散至分光元件的第二透镜/第二透镜组。The second lens/second lens group located on the heating optical path for converging/diverging the light of the projection assembly to the light splitting element.
如图2所示,本实施例的光学成像组件可包括:接收内窥镜组件传 输的待分析区域的可见光和不可见光进行滤光的滤光元件;As shown in Fig. 2, the optical imaging component of this embodiment may include: a filter element that receives visible light and invisible light of the area to be analyzed transmitted by the endoscope component for filtering;
用于对经由滤光元件后的成像光进行汇聚的第三透镜/第三透镜组;The third lens/third lens group for condensing the imaging light after passing through the filter element;
位于加热光路上的用于将投影组件的光进行汇聚/发散至物体加热区域的第二透镜/第二透镜组。The second lens/second lens group located on the heating optical path and used to converge/diverge the light of the projection assembly to the heating area of the object.
特别地,在实际应用中,投影组件可为多组,且加热光源可为多个,每一组投影组件对应一加热光源。In particular, in practical applications, there may be multiple sets of projection components, and there may be multiple heating light sources, and each set of projection components corresponds to a heating light source.
在图1至图4中所示的成像设备可为可见光成像相机、不可见光成像相机和热成像相机中的一种或多种组合。The imaging devices shown in FIGS. 1 to 4 may be one or more combinations of visible light imaging cameras, invisible light imaging cameras, and thermal imaging cameras.
此外,图1至图4所示的各组件均位于外壳内,即本实施例的装置还可包括外壳,光学成像组件、投影组件、加热光源和部分内窥镜组件均位于壳体内,且在壳体内的位置符合光学成像原理。In addition, the components shown in FIGS. 1 to 4 are all located in the housing, that is, the device of this embodiment may further include a housing, and the optical imaging assembly, projection assembly, heating light source and part of the endoscope assembly are all located in the housing, and The position in the housing conforms to the principle of optical imaging.
上述装置能够实现对治疗目标的安全、稳定和可控的加热效果:The above device can achieve a safe, stable and controllable heating effect for the treatment target:
本实施例的原理说明如下:The principle of this embodiment is explained as follows:
激发光源与可见光光源经分束光纤与内窥镜光源通路和发散透镜照射于被治疗组织,The excitation light source and the visible light source irradiate the treated tissue through the beam splitting fiber and the endoscope light source path and divergent lens,
由于被照射组织中病变区域与正常组织对于靶向材料的摄取差异,产生病变区域与正常组织的反射光/发射荧光对比,此图像经过内窥镜物镜和图像传输光路(在硬镜中为透镜组,在纤维镜中为传像光纤),经内窥镜目镜镜传递至光学成像组件,通过光学成像组件中分光元件与滤光元件传递到功能成像相机(即成像设备)的成像单元,滤光元件阻挡激发光源,透过功能图像光束。相机将图像信号传递给计算机,计算机进行图像的显示存储及分析(分析可自动实现或人为选择),利用分析结果控制液晶光阀或数字光处理(Digital Light Processing,DLP)组件。Due to the difference in the uptake of the target material between the diseased area and the normal tissue in the irradiated tissue, the reflected light/emitted fluorescence contrast between the diseased area and the normal tissue is generated. This image passes through the endoscope objective lens and the image transmission optical path (the lens in the hard mirror Group, in the fiberscope, it is the image transmission fiber), which is transmitted to the optical imaging assembly through the endoscope eyepiece lens, and is transmitted to the imaging unit of the functional imaging camera (ie imaging device) through the splitting element and filter element in the optical imaging assembly. The light element blocks the excitation light source and transmits the functional image beam. The camera transmits the image signal to the computer, and the computer performs image display, storage and analysis (analysis can be realized automatically or manually), and the analysis result is used to control the liquid crystal light valve or digital light processing (Digital Light Processing, DLP) components.
如图2和图3所示,液晶光阀采用高穿透式高温多晶硅(High Temperature Poly-Silicon,HTPS)制作,从计算机传输来的图像分析控制信号控制液晶光阀的通透区域,加热光源照射于液晶光阀,仅透明区域的光能够通过液晶光阀,经透镜组和分光元件传递至内窥镜目镜,再经内窥镜传像光路和内窥镜物镜照射于病变区域,进而实现成像引导的精 准光热治疗。As shown in Figure 2 and Figure 3, the liquid crystal light valve is made of High Temperature Poly-Silicon (HTPS). The image analysis control signal transmitted from the computer controls the transparent area of the liquid crystal light valve and heats the light source. When irradiated on the liquid crystal light valve, only the light in the transparent area can pass through the liquid crystal light valve, and be transmitted to the endoscope eyepiece through the lens group and light splitting element, and then irradiate the diseased area through the endoscope image transmission optical path and the endoscope objective lens to achieve Precise photothermal therapy guided by imaging.
如图1和图4所示,计算机的图像信号传至DLP控制器,DLP组件中的高分辨率数字微镜(DMD)接收DLP控制器的信号并改变微镜的角度,实现受功能图像控制的光反射,治疗光线的反射光经透镜组和分光元件照射于病变区域,实现受功能图像控制的精准光热治疗。As shown in Figure 1 and Figure 4, the image signal of the computer is transmitted to the DLP controller, and the high-resolution digital micromirror (DMD) in the DLP component receives the signal from the DLP controller and changes the angle of the micromirror to achieve functional image control The light reflection, the reflected light of the treatment light is irradiated on the diseased area through the lens group and the light splitting element, to realize the precise photothermal treatment controlled by the functional image.
热成像实时监控病变组织的温度,根据加热效果调整液晶光阀或DMD数字微反射器和治疗光。Thermal imaging monitors the temperature of the diseased tissue in real time, and adjusts the liquid crystal light valve or DMD digital micro reflector and the treatment light according to the heating effect.
在图1中,加热光源的加热光/照射光通过DLP组件反射,并与光学成像组件共享部分光路,与硬内窥镜配合实现成像与热疗。In Fig. 1, the heating light/irradiating light of the heating light source is reflected by the DLP component, and shares part of the optical path with the optical imaging component, and cooperates with a hard endoscope to realize imaging and thermal therapy.
在图2中,加热光源的加热光/照射光透过HTPS液晶屏投影,并与光学成像组件共享部分光路,与硬内窥镜配合实现成像与热疗。In Figure 2, the heating light/irradiation light of the heating light source is projected through the HTPS liquid crystal screen, and shares part of the optical path with the optical imaging component, and cooperates with the hard endoscope to achieve imaging and thermal therapy.
液晶光阀采用高穿透式高温多晶硅(High Temperature Poly-Silicon,HTPS)制作,从计算机传输来的图像分析控制信号控制液晶光阀的通透区域,加热光源照射于液晶光阀,仅透明区域的光能够通过液晶光阀,经透镜组和分光元件、内窥镜组件照射于病变区域,进而实现成像引导的精准光热治疗。The liquid crystal light valve is made of High Temperature Poly-Silicon (HTPS). The image analysis control signal transmitted from the computer controls the transparent area of the liquid crystal light valve. The heating light source irradiates the liquid crystal light valve, only the transparent area The light can pass through the liquid crystal light valve, irradiate the diseased area through the lens group, the light splitting element, and the endoscope assembly, so as to achieve imaging-guided precise photothermal treatment.
在图3中,加热光源的加热光/照射光透过HTPS液晶屏投影,并与光学成像组件共享部分光路,与纤维内窥镜配合实现成像与热疗。In Figure 3, the heating light/irradiating light of the heating light source is projected through the HTPS liquid crystal screen, and shares part of the optical path with the optical imaging component, and cooperates with the fiber endoscope to realize imaging and thermal therapy.
在图4中,加热光源的加热光/照射光通过DLP组件反射,并与光学成像组件共享部分光路,与纤维内窥镜配合实现成像与热疗。此时和前面附图对比,投影组件不同,本实施例的投影组件为与控制装置连接的数字光处理(Digital Light Processing,DLP)组件。In Figure 4, the heating light/irradiating light of the heating light source is reflected by the DLP component, and shares part of the optical path with the optical imaging component, and cooperates with the fiber endoscope to realize imaging and thermal therapy. At this time, compared with the previous figures, the projection component is different. The projection component of this embodiment is a digital light processing (DLP) component connected to the control device.
计算机/控制装置的图像信号传至DLP控制器,DLP组件中的高分辨率数字微镜(DMD)接收DLP控制器的信号并改变DLP组件中微镜的角度,实现受功能图像控制的光反射,加热光线的反射光经透镜组和分光元件对内窥镜组件对接,实现精准光热治疗。The image signal of the computer/control device is transmitted to the DLP controller. The high-resolution digital micromirror (DMD) in the DLP component receives the signal from the DLP controller and changes the angle of the micromirror in the DLP component to achieve light reflection controlled by the functional image , The reflected light of the heating light is connected to the endoscope assembly through the lens group and the light splitting element to achieve precise photothermal treatment.
特别说明的是,光学成像组件的成像可以是对待分析区域的可见光成像,也可以是对待分析区域的不可见光成像,本实施例不对其限定, 根据实际需要调整。It is particularly noted that the imaging of the optical imaging component may be visible light imaging of the area to be analyzed, or invisible light imaging of the area to be analyzed, which is not limited in this embodiment and is adjusted according to actual needs.
上述各实施例的结构实现了对目标视野的光学成像和热成像,实现治疗光的精准控制。The structures of the foregoing embodiments realize optical imaging and thermal imaging of the target field of view, and realize precise control of the therapeutic light.
需要理解的是,以上对本申请的具体实施例进行的描述只是为了说明本申请的技术路线和特点,其目的在于让本领域内的技术人员能够了解本申请的内容并据以实施,但本申请并不限于上述特定实施方式。凡是在本申请权利要求的范围内做出的各种变化或修饰,都应涵盖在本申请的保护范围内。It should be understood that the above description of the specific embodiments of the application is only to illustrate the technical route and characteristics of the application, and its purpose is to enable those skilled in the art to understand the content of the application and implement it accordingly. It is not limited to the specific embodiments described above. All changes or modifications made within the scope of the claims of this application shall be covered by the scope of protection of this application.
工业实用性Industrial applicability
本申请的光热治疗装置包括:内窥镜组件、光学成像组件、投影组件、加热光源和控制装置等,上述结构的光热治疗装置可以在光照治疗中实时跟随目标,实现对指定区域的照射,保证照射目标的成像。由此,具有工业实用性。The photothermal therapy device of the present application includes: an endoscope assembly, an optical imaging assembly, a projection assembly, a heating light source, a control device, etc. The photothermal therapy device with the above structure can follow the target in real time during phototherapy, and realize the irradiation of a designated area , To ensure the imaging of the illuminated target. Therefore, it has industrial applicability.

Claims (10)

  1. 一种用于内窥成像指导的光热治疗装置,其特征在于,包括:A photothermal treatment device used for endoscopic imaging guidance, which is characterized in that it comprises:
    内窥镜组件、光学成像组件、投影组件、加热光源和控制装置;Endoscope components, optical imaging components, projection components, heating light sources and control devices;
    所述光学成像组件借助于成像设备与控制装置电连接,所述投影组件与所述控制装置电连接;The optical imaging component is electrically connected with the control device by means of imaging equipment, and the projection component is electrically connected with the control device;
    所述内窥镜组件用于将待分析区域的光传输至光学成像组件,所述光学成像组件将内窥镜组件传输的光进行成像,所述光学成像组件借助于成像设备将所成图像显示在所述控制装置中;The endoscope assembly is used to transmit the light of the area to be analyzed to an optical imaging assembly, the optical imaging assembly images the light transmitted by the endoscope assembly, and the optical imaging assembly displays the resulting image by means of an imaging device In the control device;
    所述控制装置依据所成图像选择部分需要加热的部分图像,并依据选择的部分图像控制所述投影组件,使得投影组件将加热光源的加热光沿着所述光学成像组件的成像光路原路返回,以及借助于内窥镜组件将加热光传输至待分析区域中的部分或全部,以进行加热处理。The control device selects a part of the image to be heated according to the formed image, and controls the projection assembly according to the selected part of the image, so that the projection assembly returns the heating light of the heating light source along the imaging light path of the optical imaging assembly , And use the endoscope assembly to transmit the heating light to part or all of the area to be analyzed for heating treatment.
  2. 根据权利要求1所述的装置,其特征在于,内窥镜组件包括:光源、传输光纤、硬内窥镜组件;所述光源借助于传输光纤与硬内窥镜组件连接,并向待分析区域提供照射光;The device according to claim 1, wherein the endoscope assembly comprises: a light source, a transmission optical fiber, and a hard endoscope assembly; the light source is connected to the hard endoscope assembly by means of the transmission optical fiber, and is directed to the area to be analyzed Provide illuminating light;
    或者,光源、传输光纤、纤维内窥镜组件;所述光源借助于传输光纤与纤维内窥镜组件连接,并向待分析区域提供照射光。Or, a light source, a transmission fiber, and a fiber endoscope assembly; the light source is connected to the fiber endoscope assembly by means of a transmission fiber, and provides illumination light to the area to be analyzed.
  3. 根据权利要求2所述的装置,其特征在于,硬内窥镜组件包括:对应待分析区域的内窥镜物镜、与所述内窥镜物镜连接的进行光路传输的第四透镜组,与该第四透镜组连接的内窥镜目镜;The device according to claim 2, wherein the hard endoscope assembly comprises: an endoscope objective lens corresponding to the area to be analyzed, a fourth lens group connected to the endoscope objective lens for optical path transmission, and the Endoscope eyepiece connected to the fourth lens group;
    纤维内窥镜组件包括:对应待分析区域的内窥镜物镜、与所述内窥镜物镜连接的进行光路传输的传像光纤、与该传输光纤连接的内窥镜目镜;The fiber endoscope assembly includes: an endoscope objective lens corresponding to the area to be analyzed, an image transmission fiber connected to the endoscope objective lens for optical path transmission, and an endoscope eyepiece connected to the transmission fiber;
    所述内窥镜目镜与所述光学成像组件、投影组件的光路对接。The endoscope eyepiece is connected with the optical path of the optical imaging component and the projection component.
  4. 根据权利要求1所述的装置,其特征在于,The device according to claim 1, wherein:
    所述投影组件包括:与所述控制装置连接的采用高穿透式高温多晶硅制作的液晶屏或与控制装置连接的数字光处理组件。The projection component includes: a liquid crystal screen made of high-transmittance high-temperature polysilicon connected to the control device or a digital light processing component connected to the control device.
  5. 根据权利要求1至4任一所述的装置,其特征在于,所述光学成像组件包括:The apparatus according to any one of claims 1 to 4, wherein the optical imaging component comprises:
    接收内窥镜组件传输的待分析区域的可见光和不可见光的第一透镜/第一透镜组;The first lens/first lens group for receiving visible light and invisible light of the area to be analyzed transmitted by the endoscope assembly;
    位于第一透镜/第一透镜组的成像侧的能够透射成像光线并反射加热光的分光元件;A spectroscopic element located on the imaging side of the first lens/first lens group that can transmit imaging light and reflect heating light;
    位于第一透镜/第一透镜组的成像侧的,且对分光元件的透射光进行滤光的滤光元件;A filter element located on the imaging side of the first lens/first lens group and filtering the transmitted light of the light splitting element;
    用于对经由滤光元件后的成像光进行汇聚的第三透镜/第三透镜组;The third lens/third lens group for condensing the imaging light after passing through the filter element;
    位于加热光路上的用于将投影组件的光进行汇聚/发散至分光元件的第二透镜/第二透镜组。The second lens/second lens group located on the heating optical path for converging/diverging the light of the projection assembly to the light splitting element.
  6. 根据权利要求1至4任一所述的装置,其特征在于,所述光学成像组件包括:The apparatus according to any one of claims 1 to 4, wherein the optical imaging component comprises:
    接收内窥镜组件传输的待分析区域的可见光和不可见光进行滤光的滤光元件;A filter element that receives visible light and invisible light of the area to be analyzed transmitted by the endoscope assembly;
    用于对经由滤光元件后的成像光进行汇聚的第三透镜/第三透镜组;The third lens/third lens group for condensing the imaging light after passing through the filter element;
    位于加热光路上的用于将投影组件的光进行汇聚/发散至物体加热区域的第二透镜/第二透镜组。The second lens/second lens group located on the heating optical path and used to converge/diverge the light of the projection assembly to the heating area of the object.
  7. 根据权利要求1至4任一所述的装置,其特征在于,所述装置包括一组或多组投影组件和多个加热光源;The device according to any one of claims 1 to 4, wherein the device comprises one or more sets of projection components and multiple heating light sources;
    每一组投影组件对应一加热光源。Each group of projection components corresponds to a heating light source.
  8. 根据权利要求1至4任一所述的装置,其特征在于,The device according to any one of claims 1 to 4, characterized in that:
    所述成像设备为可见光成像相机、不可见光成像相机和热成像相机中的一种或多种组合。The imaging device is one or more combinations of visible light imaging camera, invisible light imaging camera and thermal imaging camera.
  9. 根据权利要求2所述的装置,其特征在于,所述光源为可见光光源或激发光源或荧光激发光源。The device according to claim 2, wherein the light source is a visible light source or an excitation light source or a fluorescent excitation light source.
  10. 根据权利要求1所述的装置,其特征在于,还包括外壳;The device according to claim 1, further comprising a housing;
    所述光学成像组件、投影组件、加热光源和部分内窥镜组件均位于壳体内,且在壳体内的位置符合光学成像原理。The optical imaging component, the projection component, the heating light source and part of the endoscope component are all located in the housing, and the positions in the housing comply with the principle of optical imaging.
PCT/CN2019/095110 2019-04-30 2019-07-08 Endoscopic imaging-guided photothermal treatment apparatus WO2020220471A1 (en)

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