WO2020213969A3 - 각막 내피 세포의 기능 부전 진단용 바이오마커 - Google Patents

각막 내피 세포의 기능 부전 진단용 바이오마커 Download PDF

Info

Publication number
WO2020213969A3
WO2020213969A3 PCT/KR2020/005133 KR2020005133W WO2020213969A3 WO 2020213969 A3 WO2020213969 A3 WO 2020213969A3 KR 2020005133 W KR2020005133 W KR 2020005133W WO 2020213969 A3 WO2020213969 A3 WO 2020213969A3
Authority
WO
WIPO (PCT)
Prior art keywords
corneal endothelial
endothelial cell
cell dysfunction
biomarker
diagnosing
Prior art date
Application number
PCT/KR2020/005133
Other languages
English (en)
French (fr)
Other versions
WO2020213969A2 (ko
Inventor
이형근
지용우
정재훈
Original Assignee
연세대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 연세대학교 산학협력단 filed Critical 연세대학교 산학협력단
Publication of WO2020213969A2 publication Critical patent/WO2020213969A2/ko
Publication of WO2020213969A3 publication Critical patent/WO2020213969A3/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/16—Ophthalmology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

본 발명은 각막 내피 세포의 기능 부전을 진단할 수 있는 바이오마커 용 바이오마커 및 이를 이용하여 각막 내피 세포의 기능 부전 정도와 이와 관련된 다양한 질환을 진단하기 위한 정보 제공 방법에 관한 것이다. 본 발명은 안구의 방수에 있어서 본 발명의 바이오마커 단백질 또는 이를 코딩하는 유전자의 발현 수준을 측정함으로써 각막 내피 세포의 기능 부전 여부 혹은 그 정도를 빠르고 용이하지만 정확하게 진단할 수 있고, 이를 통하여 상기 각막 내피 세포의 기능 부전으로 인하여 유발될 수 있는 푹스각막이영양증, 외상, 인공수정체 수포각막병증, 각막 내피염 또는 시력 손실 등의 질환을 조기에 진단하거나, 상기 질환의 경과, 예후 또는 치료 효과에 대하여도 추적이 가능하다.
PCT/KR2020/005133 2019-04-17 2020-04-17 각막 내피 세포의 기능 부전 진단용 바이오마커 WO2020213969A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2019-0044669 2019-04-17
KR20190044669 2019-04-17

Publications (2)

Publication Number Publication Date
WO2020213969A2 WO2020213969A2 (ko) 2020-10-22
WO2020213969A3 true WO2020213969A3 (ko) 2020-12-17

Family

ID=72837516

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2020/005133 WO2020213969A2 (ko) 2019-04-17 2020-04-17 각막 내피 세포의 기능 부전 진단용 바이오마커

Country Status (2)

Country Link
KR (2) KR102446567B1 (ko)
WO (1) WO2020213969A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240053830A (ko) 2022-10-18 2024-04-25 엘지디스플레이 주식회사 표시 장치
CN117590006B (zh) * 2024-01-19 2024-03-29 天津医科大学眼科医院 生物标志物在制备诊断Vogt-小柳原田综合征的产品中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2418491A1 (en) * 2010-08-10 2012-02-15 Bioftalmik, S.L. Method for the diagnosis of dry eye and blepharitis
KR20170042784A (ko) * 2014-09-05 2017-04-19 오사카 유니버시티 각막 내피 세포 마커

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012009171A2 (en) * 2010-07-15 2012-01-19 The Schepens Eye Research Institute, Inc. Compositions and methods of treatment of corneal endothelium disorders
SI2788472T1 (sl) * 2011-12-06 2019-04-30 Astellas Institute For Regenerative Medicine Način usmerjene diferencijacije, produciranja endotelijskih celic roženice
WO2015016371A1 (ja) * 2013-07-30 2015-02-05 京都府公立大学法人 角膜内皮細胞マーカー
EP3416658B1 (en) * 2016-02-15 2023-03-22 Kyoto Prefectural Public University Corporation Human functional corneal endothelial cell and application thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2418491A1 (en) * 2010-08-10 2012-02-15 Bioftalmik, S.L. Method for the diagnosis of dry eye and blepharitis
KR20170042784A (ko) * 2014-09-05 2017-04-19 오사카 유니버시티 각막 내피 세포 마커

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALENA BARTAKOVA; KAREN ALVAREZ-DELFIN; ALEJANDRA D WEISMAN; ENRIQUE SALERO; GABRIELLA A RAFFA; RICHARD M MERKHOFER; NOELIA J KUNZE: "Novel Identity and Functional Markers for Human Corneal Endothelial Cells", INVESTIGATIVE OPTHALMOLOGY & VISUAL SCIENCE, vol. 57, no. 6, 19 May 2016 (2016-05-19), pages 2749 - 2762, XP055294684, ISSN: 1552-5783, DOI: 10.1167/iovs.15-18826 *
MASAHITO YOSHIHARA, HIROKO OHMIYA, SUSUMU HARA, SATOSHI KAWASAKI, FANTOM CONSORTIUM, YOSHIHIDE HAYASHIZAKI, MASAYOSHI ITOH2, HIDEY: "Discovery of molecular markers to discriminate corneal endothelial cells in the human body", PLOS ONE, vol. 10, no. 3, e0117581, 25 March 2015 (2015-03-25), pages 1 - 14, XP055416395, DOI: 10.1371/journal.pone.0117581 *
NAOKI OKUMURA; HIROATSU HIRANO; RYOHEI NUMATA; MAKIKO NAKAHARA; MORIO UENO; JUNJI HAMURO; SHIGERU KINOSHITA; NORIKO KOIZUMI: "Cell Surface Markers of Functional Phenotypic Corneal Endothelial Cells", INVESTIGATIVE OPTHALMOLOGY & VISUAL SCIENCE, vol. 55, no. 11, 25 November 2014 (2014-11-25), pages 7610 - 7618, XP055346119, ISSN: 1552-5783, DOI: 10.1167/iovs.14-14980 *

Also Published As

Publication number Publication date
KR102446567B1 (ko) 2022-09-26
KR102604430B1 (ko) 2023-11-22
KR20220133829A (ko) 2022-10-05
KR20200122258A (ko) 2020-10-27
WO2020213969A2 (ko) 2020-10-22

Similar Documents

Publication Publication Date Title
Canadian Glaucoma Study Group Canadian Glaucoma Study: 3. Impact of risk factors and intraocular pressure reduction on the rates of visual field change
Campbell et al. Biomechanics of the posterior eye: a critical role in health and disease
Walter et al. Ganglion cell loss in relation to visual disability in multiple sclerosis
WO2020213969A3 (ko) 각막 내피 세포의 기능 부전 진단용 바이오마커
WO2013022995A3 (en) Biomarker compositions and methods
BR112012026219A2 (pt) método diagnósticos para glaucoma
RU2019103403A (ru) Адреномедуллин для оценки застоя у индивидуума с острой сердечной недостаточностью
JP6904908B2 (ja) 角膜拡張症（ｃｏｒｎｅａｌ ｅｃｔａｔｉｃ ｄｉｓｏｒｄｅｒｓ）の診断および予後診断のためのバイオマーカー
WO2020023789A3 (en) Small rna predictors for alzheimer's disease
Güldoğan et al. Correlation between ischemia-modified albumin and Ranson score in acute pancreatitis
WO2014106833A1 (en) A process for identification of biomarkers for keratoconus progression
BRPI0407300A (pt) Usos de um inibidor funcional da proteìna hsgk1 ou da proteìna hsgk3 ou de um regulador negativo da transcrição do gene hsgk1 ou do gene hsgk3, de um ácido nucleico de filamento único ou filamento duplo e de um anticorpo, fármaco, kit para diagnóstico, e, método de triagem para identificar e caracterizar substâncias terapeuticamente ativas
CN106018827A (zh) 一种阿尔茨海默症检测标志物及其检测方法
Gharishvandi et al. Assessment of Neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for detection of renal impairment in hypertensive patients
CN108982866B (zh) 尿Tenascin-C比肌酐在制备诊断和预后评估特发性IgA肾病制剂中的用途
WO2021145721A3 (ko) 기계학습을 이용한 수면무호흡증 진단방법
Saito et al. Association of Bergmeister Papilla and Deep Optic Nerve Head Structures With Prelaminar Schisis of Normal and Glaucomatous Eyes
RU92777U1 (ru) Устройство для определения механических характеристик роговицы
RU2688710C1 (ru) Способ прогнозирования прогрессирования миопии у детей
George et al. Angle closure in the developing world: what does the future hold?
Zivkovic et al. AB0540 Organ damage in patients with systemic lupus erythematosus
JP6772489B2 (ja) オートタキシン測定による心臓病等の検査方法および検査薬
KRUZLIAK et al. SANDEEP SAXENA, MS, FRCSED, FRCS, FRCOPHTH, FAICO,* SURABHI RUIA, MBBS,* SENTHAMIZH PRASAD, MBBS,† ASTHA JAIN, MS,* NIBHA MISHRA, MS,* SHANKAR M. NATU, PHD,‡ CARSTEN H. MEYER, MD, § JAGJIT S. GILHOTRA, M. MED, FRANZCO
Villani et al. Dry eye in rheumatoid arthritis: tear film osmolarity and inflammation
WANG et al. WCN23-0535 HUMAN STEM CELL-DERIVED KIDNEY ORGANOID TO MODEL DIABETIC NEPHROPATHY

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20790493

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 20790493

Country of ref document: EP

Kind code of ref document: A2