WO2020197346A3 - 녹차 유래 성분을 함유하는 바이러스 백신용 면역증강제 조성물 - Google Patents
녹차 유래 성분을 함유하는 바이러스 백신용 면역증강제 조성물 Download PDFInfo
- Publication number
- WO2020197346A3 WO2020197346A3 PCT/KR2020/004289 KR2020004289W WO2020197346A3 WO 2020197346 A3 WO2020197346 A3 WO 2020197346A3 KR 2020004289 W KR2020004289 W KR 2020004289W WO 2020197346 A3 WO2020197346 A3 WO 2020197346A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- green tea
- composition containing
- virus vaccine
- adjuvant composition
- vaccine adjuvant
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000012646 vaccine adjuvant Substances 0.000 title abstract 2
- 229940124931 vaccine adjuvant Drugs 0.000 title abstract 2
- 244000269722 Thea sinensis Species 0.000 title 1
- 235000009569 green tea Nutrition 0.000 title 1
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 abstract 3
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 abstract 3
- 229940030275 epigallocatechin gallate Drugs 0.000 abstract 3
- 239000002671 adjuvant Substances 0.000 abstract 2
- 229940094952 green tea extract Drugs 0.000 abstract 2
- 235000020688 green tea extract Nutrition 0.000 abstract 2
- 230000028993 immune response Effects 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229940037003 alum Drugs 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
본 발명은 에피갈로카테킨 갈레이트(epigallocatechin gallate; EGCG) 또는 녹차 추출물을 유효성분으로 함유하는 바이러스 백신용 면역증강제 조성물에 관한 것으로, 본 발명의 면역증강제는 다양한 바이러스에 대한 면역반응에서 우수한 면역촉진 효능을 발휘할 뿐 아니라, 독성이 거의 없어 안전성이 매우 우수하다. 또한, 본 발명의 녹차 추출물 또는 EGCG로 이루어지는 면역증강제는 Alum과 병용사용하였을 때 백신의 면역반응을 더욱 강력하게 향상시킬 수 있다.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020190035847A KR20200114310A (ko) | 2019-03-28 | 2019-03-28 | 녹차 유래 성분을 함유하는 바이러스 백신용 면역증강제 조성물 |
| KR10-2019-0035847 | 2019-03-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2020197346A2 WO2020197346A2 (ko) | 2020-10-01 |
| WO2020197346A3 true WO2020197346A3 (ko) | 2020-11-19 |
Family
ID=72610638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2020/004289 WO2020197346A2 (ko) | 2019-03-28 | 2020-03-30 | 녹차 유래 성분을 함유하는 바이러스 백신용 면역증강제 조성물 |
Country Status (2)
| Country | Link |
|---|---|
| KR (2) | KR20200114310A (ko) |
| WO (1) | WO2020197346A2 (ko) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110094935A (ko) * | 2010-02-18 | 2011-08-24 | 재단법인 하동녹차연구소 | 녹차를 유효성분으로 함유하는 조류 인플루엔자에 대한 항바이러스제 |
| KR20160147234A (ko) * | 2015-06-11 | 2016-12-22 | 연세대학교 산학협력단 | 녹차 추출물에 의해 불활화된 바이러스를 포함하는 백신 및 그의 제조방법 |
| JP2018065825A (ja) * | 2011-06-24 | 2018-04-26 | エピットジェネシス・インコーポレーテッド | 抗原特異的免疫モジュレーターとして選択担体、ビタミン、タンニンおよびフラボノイドの組み合わせを含有する医薬組成物 |
-
2019
- 2019-03-28 KR KR1020190035847A patent/KR20200114310A/ko not_active Application Discontinuation
-
2020
- 2020-03-30 WO PCT/KR2020/004289 patent/WO2020197346A2/ko active Application Filing
-
2022
- 2022-02-03 KR KR1020220014471A patent/KR102429564B1/ko active IP Right Grant
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110094935A (ko) * | 2010-02-18 | 2011-08-24 | 재단법인 하동녹차연구소 | 녹차를 유효성분으로 함유하는 조류 인플루엔자에 대한 항바이러스제 |
| JP2018065825A (ja) * | 2011-06-24 | 2018-04-26 | エピットジェネシス・インコーポレーテッド | 抗原特異的免疫モジュレーターとして選択担体、ビタミン、タンニンおよびフラボノイドの組み合わせを含有する医薬組成物 |
| KR20160147234A (ko) * | 2015-06-11 | 2016-12-22 | 연세대학교 산학협력단 | 녹차 추출물에 의해 불활화된 바이러스를 포함하는 백신 및 그의 제조방법 |
Non-Patent Citations (2)
| Title |
|---|
| AL-ZUBAIDY, I. A.: "An attempt to prepare an effective killed vaccine with an adjuvant (green tea extract) against Salmonella typhimurium", JOURNAL OF ENTOMOLOGY AND ZOOLOGY STUDIES, vol. 5, no. 4, 2017, pages 1375 - 1380, XP055753385 * |
| YUN H. LEE, YO H. JANG, YOUNG H. BYUN, YUCHEOL CHEONG, PAUL KIM, YOUNG J. LEE, YOON J. LEE, JE M. SUNG, AHYUN SON, HYE M. LEE, JIN: "Green Tea Catechin-Inactivated Viral Vaccine Platform", FRONTIERS IN MICROBIOLOGY, vol. 8, XP055753387, DOI: 10.3389/fmicb.2017.02469 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR102429564B1 (ko) | 2022-08-03 |
| KR20220027100A (ko) | 2022-03-07 |
| WO2020197346A2 (ko) | 2020-10-01 |
| KR20200114310A (ko) | 2020-10-07 |
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