WO2020192711A1 - 一种医用取样、检测一体化装置 - Google Patents

一种医用取样、检测一体化装置 Download PDF

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Publication number
WO2020192711A1
WO2020192711A1 PCT/CN2020/081282 CN2020081282W WO2020192711A1 WO 2020192711 A1 WO2020192711 A1 WO 2020192711A1 CN 2020081282 W CN2020081282 W CN 2020081282W WO 2020192711 A1 WO2020192711 A1 WO 2020192711A1
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Prior art keywords
sampling
cavity
sampling rod
diluent
liquid outlet
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PCT/CN2020/081282
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English (en)
French (fr)
Inventor
刘元
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江苏宝卫士生物科技有限公司
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Application filed by 江苏宝卫士生物科技有限公司 filed Critical 江苏宝卫士生物科技有限公司
Priority to EP20777735.0A priority Critical patent/EP3926322A4/en
Priority to US17/593,375 priority patent/US20220249070A1/en
Publication of WO2020192711A1 publication Critical patent/WO2020192711A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0038—Devices for taking faeces samples; Faecal examination devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/08—Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/8483—Investigating reagent band
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B2010/0003—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements including means for analysis by an unskilled person
    • A61B2010/0006—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements including means for analysis by an unskilled person involving a colour change
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7756—Sensor type
    • G01N2021/7759—Dipstick; Test strip

Definitions

  • the invention belongs to the field of medical reagent detection.
  • fecal occult blood is limited to professional medical institutions. When testing, professionals usually dissolve the stool in a container with a buffer solution, then pour the fecal fluid in the container into a small cup or small hole, and then put the absorbent test paper The strip is inserted into a small cup or hole for testing.
  • the stool detection process in the hospital is that the physical examiner goes to the laboratory to collect the stool sampling cup, to the bathroom to collect the stool into the stool cup, and transport it to the laboratory.
  • the inspector collects the stool and mixes it in the diluent, discards the excess stool, and opens the reagent. Pack and take out the reagents, use a pipette to draw the mixed sample and add it to the reagent sample pad, and read the result in 5-10 minutes.
  • the stool and liquid are open, and there are many times of direct viewing of the stool. It is easy to overturn and leak the liquid during operation. There are hundreds of bacteria in the stool, which is easy to cause pollution, and it is easy to cause secondary pollution when discarded after use.
  • the present invention provides a medical sampling and detection integrated device that is more convenient for detection.
  • an integrated medical sampling and detection device of the present invention includes a sampling rod and a housing; the housing includes a test paper containing cavity and a diluent cavity; the bottom of the diluent cavity is provided A liquid outlet, the liquid outlet is provided with a pore blocking material, and the upper opening of the diluent cavity is connected to the outside;
  • the plunger is placed in the dilution chamber, the plunger has a hole, the A end of the sampling rod can be detachably passed through the hole, and the B end of the sampling rod is pushed. Synchronously advance with the plunger in the diluent cavity to the end A of the sampling rod to stab the plugging at the liquid outlet.
  • test paper containing cavity contains test paper, and the sample pad of the test paper is arranged downward; the liquid flowing out from the liquid outlet can contact the reagent sample pad.
  • a separation layer is formed between the test paper accommodating cavity and the dilution chamber, a communication cavity is provided on the lower side of the separation layer, and the liquid outlet and the bottom of the test paper accommodating cavity are both connected to the communication cavity.
  • the bottom of the casing is a detachable bottom cover; after the bottom cover is disassembled, the communicating cavity is connected to the outside.
  • the outer wall of the end B of the sampling rod is movably matched with the inner wall of the dilution chamber, the outer wall of the end B of the sampling rod is provided with a stop buckle A, and the inner wall of the dilution chamber is provided with a stop buckle B.
  • the position buckle A and the limit buckle B can clamp and limit each other.
  • the diameter of the end A of the sampling rod is smaller than the diameter of the inner diameter of the liquid outlet.
  • end A of the sampling rod is a sampling end, and the sampling end has a threaded structure and is arranged downward.
  • reagent card slot and a desiccant are also placed in the reagent containing cavity, and the test paper card is located in the reagent card slot.
  • the pre-installed diluent is located between the plug in the diluent cavity and the plunger.
  • the present invention has a simple structure, integrates stool sample collection, dilution, mixing, sample addition, and detection. Ordinary people can screen high-risk groups of bowel cancer and gastric cancer at home.
  • the structure is clever and easy to use.
  • the structure also ensures The tightness of the diluent pre-filled in the liquid bottle is improved. This solves the core problems of fecal sampling, transportation, short storage time, and pollution.
  • Colorectal cancer includes colon cancer and rectal cancer. It is one of the five major malignant tumors with a very high incidence. Almost 80% of colorectal cancers are advanced when they are discovered, and the mortality rate of colorectal cancer is also very high.
  • Figure 1 is a cut-away schematic diagram of the overall structure of the device
  • Figure 2 is a schematic diagram of the structure of the sampling rod
  • Figure 3 is a schematic diagram of the shell structure
  • Fig. 4 is a schematic diagram of the structure after the plunger is removed on the basis of Fig. 2.
  • a medical sampling and testing integrated device includes a sampling rod 15 and a shell.
  • the shell of this embodiment is a transparent plastic structure as shown in Figure 3; the shell includes test paper The accommodating cavity 2 and the cylindrical diluent cavity 5; the bottom of the diluent cavity 5 is provided with a liquid outlet 4, and the liquid outlet 4 is provided with a pore blocking object 14.
  • the pore blocking object 14 in this embodiment is Round silicone material;
  • the plunger 16 of this embodiment is made of round silica gel and has a circular hole 016 at the coaxial position.
  • the end A of the sampling rod can pass downward through the circular hole 016 on the plunger 16.
  • the diameter of the circular hole 016 matches the diameter of the end 8 of the sampling rod.
  • the end 8 of the sampling rod can be sealed to block the circular hole 016 after passing through the circular hole 016.
  • the thread of the end 8 of the sampling rod A passes through the round hole 016, the excess feces on the thread can be scraped out, achieving the effect of quantitatively collecting stool samples.
  • the plunger 16 is coaxially movably placed in the diluent cavity 5 and closely fits with the diluent cavity 5.
  • the diluent is pre-installed between the plug 14 and the plunger 16 in the diluent cavity 5;
  • the two ends of the sampling rod 15 in this embodiment are the A-end 8 and the B-end 18 respectively.
  • the A-end 8 in this embodiment is the sampling end.
  • the sampling end has a threaded structure and is arranged downward.
  • the sampling end of the threaded structure Used to stick stool samples; the B end of this embodiment has an outer diameter that is compatible with the diluent cavity 5, and the top of the B end 18 of this embodiment is provided with a pressing plate 17, which can be pushed down by pressing down
  • the sampling rod 15 can be pushed into the diluent chamber 5 with the plunger 16 to the A end 8 of the sampling rod 15 to poke the plugging material 14 at the outlet 4, and the liquid flows out from the outlet 4 to the connection under the action of pressure.
  • the diameter of the A-end 8 of the sampling rod 15 in this embodiment is smaller than the diameter of the inner diameter of the liquid outlet 4.
  • the test paper accommodating cavity 2 contains a test paper 11, and the sample pad 12 of the test paper 11 is arranged downward; the liquid flowing out of the liquid outlet 4 can contact the reagent sample pad 12; in addition, to ensure that the test paper accommodating cavity 2
  • the degree of dryness and the fixing of the test paper, the reagent card slot 05 and the desiccant 03 are also placed in the reagent containing cavity 2 of this embodiment, and the test paper 11 is stuck in the reagent card slot 05. Between the test paper 11 and the desiccant 03 is a card slot 05, and the card slot 05 separates the test paper 11 from the desiccant 03.
  • a separation layer 3 is formed between the test paper accommodating cavity 2 and the dilution cavity 5, a communication cavity 1 is provided on the lower side of the separation layer 3, and the liquid outlet 4 and the bottom of the test paper accommodating cavity 2 are both connected to the communication cavity 1
  • the bottom of the casing of this embodiment is a detachable bottom cover 13; the bottom cover 13 seals the communicating cavity 1 at the bottom of the casing. After the bottom cover 13 is removed, the communicating cavity 1 communicates with the outside world. The removal of the bottom cover 13
  • the structure is convenient for pre-filling the reagent card slot 05, desiccant 03 and test paper 11 before leaving the factory;
  • the outer wall of the B end 18 of the sampling rod 15 is movably matched with the inner wall of the dilution chamber 5.
  • the outer wall of the B end 18 of the sampling rod 15 is provided with a section of limit buckle A30.2, which is made of two sections of plastic material. Ring structure, the inner wall of the dilution chamber 5 is provided with a section of limit buckle B30.1, the limit buckle B30.1 and the limit buckle A30.2 are matched with plastic material, one of the limit buckles is a concave structure, and the other is Convex structure.
  • the limit buckle A30.1 and the limit buckle B30.2 can clamp each other in the limit. When in use, press hard or pull the pressing plate 17 outward to make the limit.
  • the plastic material of the buckle A30.1 and the limit buckle B30.2 jammed with each other is deformed, and the limit buckle A30.1 and the limit buckle B30.2 are separated from each other, and the limit function is lost; the limit buckle A30. 1 and limit buckle B30.2 play a limit role of sampling rod 15;
  • the diluent is pre-installed between the plug 14 and the plunger 16 in the diluent cavity 5, and the housing structure is first placed upright, holding the housing tightly with one hand, and then holding the B end 18 upward Pull out the sampling rod 15, hold the B end of the sampling rod and use the threaded structure of the A end 8 of the sampling rod 15 to collect stool samples at multiple points, and then hold the B end and pass the A end 8 of the sampling rod 15 through the round hole on the plunger 16 016, the round hole 016 scrapes off the excess feces on the 8 screws at end A and the sampling rod A end blocks the round hole 016, and the sampling rod A end is reinserted into the dilution chamber 5 and comes into contact with the diluent, while the limit buckle B30.1 And the limit buckle A30.2 are stuck with each other.
  • the downward push of the plunger 16 increases the pressure in the dilution chamber 5, and then when the A end 8 is opened
  • the diluent mixed with the sample in the dilution chamber 5 will quickly gush out through the gap between the end A of the sampling rod and the liquid outlet 4 and flow into the communicating cavity 1.
  • the A end of the rod 15 is still in the tapped liquid outlet 4, and then the liquid that quickly flows through the liquid outlet 4 can also flush the feces remaining on the A end of the sampling rod 15, so that the A end of the sampling rod 15
  • the stool sample adhered to the upper surface is thoroughly washed, thereby effectively ensuring that there is a sufficient amount of stool sample in the diluent; the liquid flowing into the communication chamber 1 will quickly infiltrate the sample pad 12 at the lower end of the test paper 11, and the liquid will slowly climb under the action of chromatography All contact with the test paper, the sample reacts with the test paper for 5-10 minutes to interpret the chromatographic reaction result through the test paper.
  • C line T mark on the test paper strip, and only one C line is negative, and two lines C and T are displayed. All are shown as positive. If the C line T does not show the line, it means the test has failed. In this way, collection, dilution, sample addition, and detection can be integrated.

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Abstract

一种医用取样、检测一体化装置，包括采样棒(15)和壳体；壳体内包括试纸容纳腔(2)和稀释液腔(5)；稀释液腔(5)的底部设有出液口(4)，出液口(4)上设有堵孔物(14)；采样棒(15)上连接有柱塞(16)，柱塞(16)置于稀释液腔(5)中，采样棒(15)的两端分别为A端(8)和B端(18)，推动采样棒(15)的B端(18)，采样棒(15)能随柱塞(16)在稀释液腔(5)内推进至采样棒(15)的A端(8)捅开出液口(4)处的堵孔物(14)；结构简单，能同时实现粪便的取样、稀释和检测；同时可使粪便样本采集、稀释、混匀、加样、检测一体化，普通人在家就可以筛查肠癌和胃癌高危人群，社会意义重大；结构巧妙，使用方便，还保证了预装稀释液的密封性。

Description

一种医用取样、检测一体化装置 技术领域
本发明属于医用试剂检测领域。
背景技术
常规便隐血检测需由被检者留取粪便送检，由医院专业人员检测。但是，由于粪便采集和送检的标本保存和运送要求较高，而到医院参加体检者经常忽略或没有便意而不送检粪便。顾粪便检查是我国及全球弃检率最高的项目。但粪便样本检测是世界卫生组织、美国肿瘤协会、中国专家共识用于肠癌筛查的第一推荐方法，目前粪便检测肠癌的特异性接近80％，而血液检测肠癌特异性仅有30％左右。
目前市面上尚无适合大便隐血自测的器具，一些免疫金标法大便隐血试剂厂家设计有各自的采便器，但其采便器无采样量控制装置，且均不包括检测器，所有检测都必需开放粪性液体。目前大便隐血仅限于专业医疗机构内进行，专业人员检测时一般先将粪便置于带缓冲液的容器内溶解，再将容器内粪液倒入小杯或小孔中，再将吸液试纸条插入小杯或小孔进行检测。
目前医院粪便检测流程为，体检者去检验科领取粪便采样杯，去卫生间采集粪便到粪便杯里，运输到检验科，检验人员采集粪便到稀释液中进行混匀，丢弃掉多余粪便，打开试剂包装取出试剂，用吸管吸取混匀后的样本加在试剂样本垫上，5-10分钟判读结果。检测中粪便及液体开放，直视粪便次数多，操作中容易倾覆溢漏液体，粪便中有数百种细菌，容易造成污染，并且使用完后丢弃容易造成二次污染。
粪便常规检验采集标本后，应在1-2小时内完成检查，否则可因pH及消化酶等影响，使粪便中细胞成份破坏分解。因粪便样本不能像血液样本一样随时可以采集，体检者从家里采集后运输到需要体检的地方的时间和到检验科是否马上能检测的时间不确定性，也是造成弃检的主要原因。运输粪便容易不卫生、耽误时间、尴尬等也是造成粪便弃检的主要原因。
发明内容
发明目的：为了克服现有技术中存在的不足，本发明提供一种检测更加方便的一种医用取样、检测一体化装置。
技术方案：为实现上述目的，本发明的一种医用取样、检测一体化装置，包括采 样棒和壳体；所述壳体内包括试纸容纳腔和稀释液腔；所述稀释液腔的底部设有出液口，所述出液口上设有堵孔物，所述的稀释液腔上口连通外界；
进一步的，还包括柱塞，所述柱塞置于所述稀释腔中，所述柱塞上有孔，采样棒A端可拆卸的穿过所述孔，推动采样棒的B端，采样棒与柱塞在稀释液腔内同步推进至采样棒的A端捅开出液口处的堵孔物。
进一步的，所述试纸容纳腔内容纳有试纸，所述试纸的样品垫朝下设置；从出液口流出的液体能与试剂样品垫接触。
进一步的，所述试纸容纳腔与稀释腔之间形成分隔层，所述分隔层的下侧设置有连通腔，所述出液口和试纸容纳腔底部均连通所述连通腔。
进一步的，所述壳体的底部为可拆卸的底盖；所述底盖拆卸后，连通腔连通外界。
进一步的，采样棒的B端外壁与所述稀释腔内壁活动配合，所述采样棒B端的外壁上设置有一段限位扣A，所述稀释腔内壁设置有一段限位扣B，所述限位扣A与所述限位扣B能互相卡住限位。
进一步的，采样棒A端的直径小于出液口内径的直径。
进一步的，所述采样棒的A端为采样端，所述采样端上有螺纹结构，并朝下设置。
进一步的，试剂容纳腔内还放有试剂卡槽和干燥剂，所述试纸卡位于所述试剂卡槽中。
进一步的，预装稀释液位于稀释液腔内的堵孔物与柱塞之间。
有益效果：本发明的结构简单，集粪便样本采集、稀释、混匀、加样、检测一体化，普通人在家就可以筛查肠癌和胃癌高危人群，结构巧妙，使用方便，该结构还保证了液体瓶内预装的稀释液的密封性。从而解决了粪便取样送检难、运输难、样本保存时间短、污染等核心问题，大肠癌包括结肠癌和直肠癌，它是五大恶性肿瘤之一，发病率是非常高的。有差不多80％的大肠癌，在发现的时候都是晚期，而且大肠癌的死亡率也是非常高的。早期发现结肠癌无淋巴结转移，通过手术切除，五年生存率可达90％以上。本发明操作简单，可全球普及，可有效降低肠癌全球死亡率。是肠癌筛查在家即可完成，社会意义重大。
附图说明
附图1为本装置的整体结构剖开示意图；
附图2为采样棒结构示意图；
附图3为壳体结构示意图；
附图4为在附图2的基础上将柱塞拆下后的结构示意图。
具体实施方式
下面结合附图对本发明作更进一步的说明。
如附图1至4所示的一种医用取样、检测一体化装置，包括采样棒15和壳体，本实施例的壳体为如图3所示的透明塑料结构；所述壳体内包括试纸容纳腔2和圆柱形的稀释液腔5；所述稀释液腔5的底部设有出液口4，所述出液口4上设有堵孔物14，本实施例的堵孔物14为圆形硅胶材质；
还包括柱塞16，所述柱塞16置于所述稀释腔5中，如图4，本实施例的柱塞16为圆形硅胶材质并同轴心位置有圆孔016，本实施例的采样棒A端能向下穿过柱塞16上的圆孔016，圆孔016与采样棒A端8直径相适，采样棒A端8穿过圆孔016后可密封堵住圆孔016，并且采样棒A端8螺纹通过圆孔016时可以刮出螺纹上的多余粪便，达到定量采集粪便样本的效果。该柱塞16同轴心活动置于该稀释腔5中并与稀释液腔5紧密配合，本实施例的稀释液腔5内的堵孔物14与柱塞16之间预装有稀释液；本实施例的采样棒15的两端分别为A端8和B端18，本实施例的A端8为采样端，该采样端上有螺纹结构，并朝下设置，该螺纹结构的采样端用于粘取粪便样品；本实施例的B端为外径与稀释液腔5相适，本实施例的B端18的顶部设置有按压盘17，向下按压该按压盘17能向下推动采样棒15能随柱塞16在稀释液腔5内推进至采样棒15的A端8捅开出液口4处的堵孔物14，在压力的作用下液体从出液口4流出到达连通腔1中，为了保证A端8能顺利的捅开出液口4处的堵孔物14并流畅流出液体，本实施例的采样棒15A端8的直径小于出液口4内径的直径。
所述试纸容纳腔2内容纳有试纸11，所述试纸11的样品垫12朝下设置；从出液口4流出的液体能与试剂样品垫12接触；另外为了保证其试纸容纳腔2中的干燥程度及固定试纸，本实施例的试剂容纳腔2内还放有试剂卡槽05和干燥剂03，所述试纸11卡位于所述试剂卡槽05中。试纸11与干燥剂03中间为卡槽05，卡槽05将试纸11与干燥剂03隔离。
所述试纸容纳腔2与稀释腔5之间形成分隔层3，所述分隔层3的下侧设置有连通腔1，所述出液口4和试纸容纳腔2底部均连通所述连通腔1；本实施例的壳体的底部为可拆卸的底盖13；底盖13密封壳体的底部的联通腔1，所述底盖13拆卸后，连通腔1连通外界，该底盖13的拆卸结构便于试剂卡槽05、干燥剂03以及试纸11的出厂前进行预填装；
采样棒15的B端18外壁与所述稀释腔5内壁活动配合，所述采样棒15B 端18的外壁上设置有一段限位扣A30.2，限位扣A30.2为两段塑料材质的环体结构，所述稀释腔5内壁设置有一段限位扣B30.1，限位扣B30.1与限位扣A30.2相配合的塑料材质，限位扣一个为凹行结构，一个为凸形结构，在出厂状态下，限位扣A30.1与所述限位扣B30.2能互相卡住限位，在使用时用力按压或用力向外拉该按压盘17，能使限位扣A30.1和限位扣B30.2相互卡住的塑料材质发生形变，进而限位扣A30.1与限位扣B30.2之间相互分开，失去限位功能；该限位扣A30.1与限位扣B30.2起到采样棒15的限位作用；
本装置的具体操作方法：
本实施例的稀释液腔5内的堵孔物14与柱塞16之间预装有稀释液，先将该壳体结构正立放置，一只手紧握壳体，然后手持B端18向上拉出采样棒15，手持采样棒B端然后用采样棒15A端8的螺纹结构在粪便多点采集粪便样品，然后手持B端将采样棒15的A端8穿过柱塞16上的圆孔016，圆孔016刮去A端8螺丝上多余的粪便并采样棒A端堵住圆孔016，采样棒A端重新插入稀释腔5中，并与稀释液接触，同时限位扣B30.1与限位扣A30.2互相卡住，此时开始进行摇匀稀释腔5，使采样棒15的A端上粘附的粪便样品与在稀释腔5中的稀释液充分混匀，然后继续向下按压该按压盘17，同时限位扣B30.1与限位扣A30.2分离，采样棒15随柱塞16在稀释液腔5内推进至采样棒15的A端8捅开出液口4处的堵孔物14，液体从出液口4流出到达连通腔1中，与此同时由于柱塞16的向下推进，使稀释腔5内的压力变大，进而当A端8捅开出液口4处的堵孔物14时，该稀释腔5内混合有样品的稀释液会迅速通过采样棒A端与出液口4之间缝隙涌出并流向连通腔1中，此时采样棒15的A端还处于被捅开的出液口4中，进而快速流过出液口4的液体还能对采样棒15的A端上残留的粪便进行冲刷，使采样棒15的A端上粘附的粪便样本彻底冲刷干净，进而有效保证稀释液中有足够量的粪便样本；流入连通腔1中的液体会迅速浸润试纸11下端的样品垫12，层析的作用下液体会缓慢爬升与试纸全部接触，样本与试纸反应5-10分钟即可通过检测试纸判读层析反应结果，试纸条上有C线T标注，只显示一条C线为阴性，C线和T线两条线都显示为阳性，C线T没有显示线则为试验失败，这样可采集、稀释、加样、检测一体化完成。
以上所述仅是本发明的优选实施方式，应当指出：对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以做出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。

Claims (9)

  1. 一种医用取样、检测一体化装置，其特征在于：包括采样棒(15)和壳体；所述壳体内包括试纸容纳腔(2)和稀释液腔(5)；所述稀释液腔(5)的底部设有出液口(4)，所述出液口(4)上设有堵孔物(14)；所述的稀释液腔(5)上口(6)连通外界；
    所述采样棒(15)的两端分别为A端(8)和B端(18)，推动采样棒(15)的B端(18)，采样棒(15)在稀释液腔(5)内推进至采样棒(15)的A端(8)捅开出液口(4)处的堵孔物(14)，液体从出液口(4)流入连通腔(1)并与试剂样品垫(12)接触。
  2. 根据权利要求1所述的一种医用取样、检测一体化装置，其特征在于：还包括柱塞(16)，所述柱塞(16)置于所述稀释腔(5)中，所述柱塞(16)上有孔(016)，采样棒(15)A端可拆卸的穿过所述孔(016)，推动采样棒(15)的B端(18)，采样棒(15)与柱塞(16)在稀释液腔(5)内同步推进至采样棒(15)的A端(8)捅开出液口(4)处的堵孔物(14)。
  3. 根据权利要求1所述的一种医用取样、检测一体化装置，其特征在于：所述试纸容纳腔(2)与稀释腔(5)之间形成分隔层(3)，所述分隔层(3)的下侧设置有连通腔(1)，所述出液口(4)和试纸容纳腔(2)底部均连通所述连通腔(1)。
  4. 根据权利要求1所述的一种医用取样、检测一体化装置，其特征在于：所述壳体的底部为可拆卸的底盖(13)；所述底盖(13)拆卸后，连通腔(1)连通外界。
  5. 根据权利要求1所述的一种医用取样、检测一体化装置，其特征在于：试剂容纳腔(2)内还放有试纸(11)试剂卡槽(05)和干燥剂(03)，所述试纸(11)卡位于所述试剂卡槽(05)中，所述试纸(11)的样品垫(12)朝下设置；
  6. 根据权利要求3所述的一种医用取样、检测一体化装置，其特征在于：采样棒(15)的B端(18)外壁与所述稀释腔(5)内壁活动配合，所述采样棒(15)B端(18)的外壁上设置有一段限位扣A(30.2)，所述稀释腔(5)内壁设置有一段限位扣B(30.1)，所述限位扣A(30.1)与所述限位扣B(30.2)能互相卡住限位。
  7. 根据权利要求1所述的一种医用取样、检测一体化装置，其特征在于：采样棒(15)A端(8)的直径小于出液口(4)内径的直径。
  8. 根据权利要求1所述的一种医用取样、检测一体化装置，其特征在于：所述采样棒(15)的A端(8)为采样端，所述采样端上有螺纹结构，并朝下设 置。
  9. 根据权利要求1所述的一种医用取样、检测一体化装置，其特征在于：预装稀释液位于稀释液腔(5)内的堵孔物(14)与柱塞(16)之间。
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