WO2020188309A1 - Garrot vibrant et procédés de collecte de sang l'utilisant - Google Patents

Garrot vibrant et procédés de collecte de sang l'utilisant Download PDF

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Publication number
WO2020188309A1
WO2020188309A1 PCT/IB2019/000271 IB2019000271W WO2020188309A1 WO 2020188309 A1 WO2020188309 A1 WO 2020188309A1 IB 2019000271 W IB2019000271 W IB 2019000271W WO 2020188309 A1 WO2020188309 A1 WO 2020188309A1
Authority
WO
WIPO (PCT)
Prior art keywords
digit
cradle portion
blood
vibrating
vibrations
Prior art date
Application number
PCT/IB2019/000271
Other languages
English (en)
Inventor
Taufeeq Elahi DIJU
Ronan RYAN
Original Assignee
Paulus Holdings Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paulus Holdings Limited filed Critical Paulus Holdings Limited
Priority to PCT/IB2019/000271 priority Critical patent/WO2020188309A1/fr
Publication of WO2020188309A1 publication Critical patent/WO2020188309A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150083—Means for enhancing collection by vibration, e.g. ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150068—Means for enhancing collection by tissue compression, e.g. with specially designed surface of device contacting the skin area to be pierced
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
    • A61B5/0051—Detecting, measuring or recording by applying mechanical forces or stimuli by applying vibrations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
    • A61B5/0053—Detecting, measuring or recording by applying mechanical forces or stimuli by applying pressure, e.g. compression, indentation, palpation, grasping, gauging

Definitions

  • a tourniquet may be placed tightly around some portion of an extremity, typically between the subject’s heart and the location from which the blood sample is collected or drawn.
  • a tourniquet e.g., an elastic band
  • the tourniquet restricts the flow of blood to the sampling or drawing location and also makes the veins inside the subject’s elbow more pronounced and easier to find and to puncture with a needle.
  • a similar device does not exist for capillary blood collection, for example from the subject’s finger.
  • finger tourniquets have been used to stop blood flow entirely but not to restrict the flow of blood to the end of the digit where a blood sample is usually collected.
  • Very small volumes of blood e.g., about 150 m ⁇
  • a tourniquet e.g., using a capillary pipette
  • larger volumes of blood are generally not sampled from a subject’s fingertip.
  • Taking a blood sample from a subject’s finger using capillary blood collection techniques can also be challenging due to dozens of variables that might reduce capillary blood flow. For example, dehydration, fatigue, lack of exercise, cold weather, and cold hands may reduce blood flow to the collection site. Circulatory disorders, resulting from, for example, obesity, diabetes mellitus, arthritis, disability, heart conditions, and arterial issues, may also cause reduced blood flow to peripheral regions, such as the subject’s hands or feet. BRIEF SUMMARY OF THE INVENTION
  • a device and method for collecting capillary blood from a mammalian digit that increase the volume of blood proximate or in the vicinity of the point of blood collection and that, furthermore, encourage blood to flow in the capillaries during the drawing process.
  • some embodiments of the present invention include a device for collecting blood from a mammalian digit.
  • the device may include a rigid cradle portion structured and arranged to retain the digit, a first biasing device releasably attachable to the cradle portion and structured and arranged to constrict blood flow in the digit, a housing portion releasably connectable to the cradle portion, and a plurality of vibrating motors located beneath the cradle portion within the housing portion, such that vibrations translated to the digit enhance blood flow.
  • the cradle portion may be a vibrating plate that includes a plurality of ribs
  • the first biasing device may be any one of an elastic device, an elastic band, a rubber device, a rubber band, and/or a hook and pile combination.
  • the device also may include one or more of the following: a power source(s) (e.g., a battery), a second biasing device (e.g., a spring) located in the housing portion and structured and arranged to bias the vibrating motors against the cradle portion, and/or a processing device adapted to combine vibrations waves from each of the vibrating motors to produce the resulting low frequency wave.
  • a power source(s) e.g., a battery
  • a second biasing device e.g., a spring located in the housing portion and structured and arranged to bias the vibrating motors against the cradle portion
  • a processing device adapted to combine vibrations waves from each of the vibrating motors to produce the resulting low frequency wave.
  • each of the vibrating motors may include a shaft and a weight that is located off center from the shaft, so that the off center weight produces vibration that, in some variations, may be combined to provide a resulting wave characterized as having a low frequency.
  • some embodiments of the present invention involve a method of collecting capillary blood from a mammalian digit.
  • the method may include providing a tourniquet device to constrict blood flow in the digit, wherein the tourniquet device may include a rigid cradle portion structured and arranged to retain the digit, a first biasing device (e.g., elastic device, an elastic band, a rubber device, and a rubber band) releasably attachable to the cradle portion, a housing portion releasably connectable to the cradle portion, and a plurality of vibrating motors located beneath the cradle portion within the housing portion.
  • a first biasing device e.g., elastic device, an elastic band, a rubber device, and a rubber band
  • the method may further include: positioning the first biasing device over the digit retained in the cradle portion; releasably attaching the first biasing device to the cradle portion to constrict blood flow in the digit; and producing vibrations by the vibrating motors, such that the vibrations translate to the digit retained in the cradle portion, thereby increasing blood flow into capillaries in the digit for collection.
  • the method may also include controlling the vibrating motors to produce vibrations having a low frequency and/or a high amplitude.
  • vibration waves having a high frequency and a high amplitude may be produced by each vibrating motor and, furthermore, these high frequency vibrations may be combined to create a resultant low frequency output.
  • FIG. 1 shows a top perspective view of a device for collecting blood, in accordance with some embodiments of the present invention
  • FIG. 2 shows a top perspective view of the device of FIG. 1 with the biasing element attached to each of the attachment posts, in accordance with some embodiments of the present invention
  • FIG. 3 shows a front view of the device of FIG. 1, in accordance with some embodiments of the present invention
  • FIG. 4 shows a front view of the device of FIG. 2, in accordance with some embodiments of the present invention.
  • FIG. 5 shows a cross sectional view of the device of FIG. 1, in accordance with some embodiments of the present invention
  • FIG. 6 shows an exploded view of a coin-type vibrating motor, in accordance with some embodiments of the present invention.
  • FIG. 7 shows a flow chart of a method of drawing blood, in accordance with some embodiments of the present invention.
  • FIG. 8 shows a middle finger inserted in the device of FIG. 1, in accordance with some embodiments of the present invention.
  • Fig. 9 shows constructive and destructive interference of a vibratory wave, in accordance with some embodiments of the present invention.
  • the device 100 includes an upper (cradle) portion 10, a biasing element 15, and a lower (housing) portion 20 that are each structured and arranged to accommodate a human finger for the purpose of collecting capillary blood.
  • the cradle portion 10 may include an arcuate shaped substrate 12 made of plastic, metal, or a combination thereof and having a proximal end 14 and a distal end 16.
  • the arcuate-shaped substrate 12 is adapted and dimensioned to accommodate all or some portion of a human digit.
  • a vibrating plate 11 includes a plurality of ribs.
  • the ribbed, vibrating plate 11 may provide an interface between the human skin and the vibratory motors.
  • the ribbed, vibrating plate 11 is translatable, so that the ribbed, vibrating plate 11 is able to conduct vibrations from vibratory motors to the subject’s digit.
  • the vibrating plate 11 is ribbed to create greater friction against the skin of the digit.
  • the individual ribs of the ribbed, vibrating plate 11 may be oriented normal, perpendicular, or substantially perpendicular to the longitudinal axis of the cradle portion 10.
  • the ribs of the vibrating plate 11 support and contact portions of the digit, ensuring that the portions of the digit are in and remain in communication with the ribbed, vibrating plate 11.
  • the vibrating plate 11 of the present invention is described as being ribbed, those of ordinary skill in the art can appreciate that other patterns and/or textures could be used as an alternative.
  • an extended rib portion 13 may be provided through the ribbed, vibrating plate 11. As shown in FIGS. 1 and 2, the extended rib portion 13 may be located within the invert of the arcuate- shaped substrate 12 and, more particularly, the extended rib portion 13 may be located within an opening in the vibrating plate 11 provided therefor. In some variations of the cradle portion 10, when a digit is placed within the device 100, the middle phalanx and/or the proximal phalanx of a finger may cover and contact the extended rib portion 13. Also, as shown in FIGS.
  • the ribs in the extended rib portion 13 project above the ribs in the vibrating plate 11. This feature ensures that, when a digit is placed in the cradle portion 12, the digit contacts the extended rib portion 13, which will automatically turn on the device 100. More specifically, once the digit contacts the extended rib portion 13, the force applied by the digit on the extended rib portion 13 will force the extended rib portion 13 down, through the opening in the vibrating plate 11. The extended rib portion 13 depresses an ON/OFF button that may be located on a printed circuit board located beneath the vibrating plate 11.
  • projections 18 extend at both ends 14, 16 of and from both sides of the arcuate- shaped substrate 12, so as to produce open sections 17 on both sides of the arcuate shaped substrate 12.
  • the open sections 17 provide a space for looping the biasing element 15 (e.g., an elastic device, an elastic band, a rubber device, a rubber band, a hook and pile combination, and the like) over the digit, ensuring that the biasing element 15 remains in intimate contact with the digit, so that the biasing element 15 constricts the flow of blood to the fingertip.
  • the biasing element 15 e.g., an elastic device, an elastic band, a rubber device, a rubber band, a hook and pile combination, and the like
  • the housing portion 20 may include an upper portion 22 and a lower portion 24.
  • the lower portion 24 may be releasably connectable to the upper portion 22 using one or more connecting devices 26 that may be disposed on opposing sides of the housing portion 20.
  • a set e.g., a pair
  • attachment posts 28 may also be fixedly attached on opposing sides of the upper portion 22 of the housing portion 20.
  • the biasing element 15 may be looped around each of the attachment posts 28 on both sides of the housing portion 20 to place the biasing element 15 in tension.
  • a bar may be fixedly attached between the attachment posts 28 on each side of the upper portion 22 of the housing portion 20, such that there is a space formed between the bar and the upper portion 22 of the housing portion 20.
  • One end of the hook and pile combination may be securely attached around the bar on one side of the upper portion.
  • the free-running end of the hook and pile combination may be inserted in the space between the bar and the upper portion 21 of the housing portion 20; pulled tightly back onto itself to apply pressure to the digit in the cradle portion 12; and the hook portion and pile portion may be brought into contact with one another to maintain the pressure on the digit.
  • Additional components of the device 100 may be located within the housing portion 20.
  • the housing portion 20 may include a number of plenum spaces 51, 52, 53.
  • one or more of the plenum spaces 51, 52 may be dimensioned and configured to accommodate a power source 54 (e.g., one or more DC battery), while other plenum space 53 may be dimensioned and configured to accommodate a printed circuit board (PCB) 55, as well as a plurality of (e.g., two) vibrating motors 56a, 56b.
  • a power source 54 e.g., one or more DC battery
  • PCB printed circuit board
  • the vibrating motors 56a, 56b are fixedly attached to the PCB 55 and the PCB 55 is fixedly attached to the ribbed, vibrating plate 11, so that, in operation, the vibrating motors 56a, 56b cause the PCB 55, the vibrating plate 1, and the digit to vibrate.
  • the spring 58 provides some damping such that a majority of the vibrations are carried to the vibrating plate 11 and the finger and very little of the vibrations is directed towards other parts of the device 100.
  • An ON/OFF button 57 may be provided on the PCB 55, while a second biasing element 58 (e.g., a spring) may be disposed against the underside of the PCB 55.
  • a second biasing element 58 e.g., a spring
  • an extending rib portion 13 and an ON/OFF button 57 may be provided to provide an auto-start capability
  • a conventional ON/OFF switch e.g., a slider switch, a push switch, and the like
  • a conventional ON/OFF switch e.g., a slider switch, a push switch, and the like
  • the PCB 55 may include a processing device (e.g., a microprocessor unit) that is capable of executing a software program, algorithm, driver program and the like stored in memory.
  • the software program, algorithm, driver program and the like may be adapted to control the frequency and/or amplitude of the vibrations produced by each motor 56a, 56b, thereby defining the final beating frequency output.
  • the PCB 55 may also include other hardware and/or software for driving the motors 56a, 56b, voltage regulators, and other circuit protection components on the PCB 55.
  • the extended rib portion 13 and ribbed, vibrating plate 11 may be configured to translate freely up and down within the arcuate-shaped substrate 12 of the cradle portion 10.
  • the extended rib portion 13 is structured and arranged to displace (e.g., in a downward direction) with respect to the vibrating plate 11, further depressing the ON/OFF button 57 sufficiently to turn on the PCB 55 and/or cause the PCB 55 to execute a start-up program.
  • the spring 58 may be adapted to ensure that, during vibration, the vibrating motors 56a, 56b stay in intimate contact with the ribbed, vibrating plate 11 and, moreover, that the ribbed, vibrating plate 11 remains in intimate contact with the digit in the cradle portion 10.
  • the PCB 55 may include one or more software programs, algorithms, driver programs, and the like to cause the plurality of vibrating motors 56a, 56b to generate vibrations in a desired manner and fashion. More particularly, it may be desirable for the vibrating motors 56a, 56b to generate vibrations in a beating phenomenon or at a beating frequency.
  • An exemplary, coin-type vibrating motor 56a, 56b suitable for use with the device 100 is shown in FIG. 6.
  • the vibrating motors 56a, 56b may include an upper casing 61 and a lower casing 62, the lower casing including a shaft 63.
  • a substrate 64 that includes a printed circuit board may be configured to include an opening adapted to fit over the shaft 63.
  • Power for running the motors 56a, 56b may be provided to components on the substrate via an electrical bus on the PCB 55 or, in the alternative, power may be provided directly from the power source 54, e.g., via electrical leads 65 from the power source 54 to the motors 56a, 56b.
  • a pair of brushes 66 may be located on the substrate 64.
  • a magnet 67 may be adapted to surround the brushes 66.
  • An imbalanced weight 68 having a plurality of coil assemblies 69 may be placed over the shaft 63 and atop the magnet 67.
  • the brushes 66 provide power selectively or alternately to the coil assemblies 69, thereby alternating the direction of a magnetic field induced by current flowing through the coil assemblies 69.
  • the induced magnetic field interacts with the magnetic flux from the magnet 67.
  • the alternating direction of the induced magnetic field and the interaction between the induced magnetic field and the magnetic flux cause the imbalanced weight 68 to rotate about the shaft 63. Due to an off-center mass in the imbalanced weight 68, the rotating imbalanced weight 68 produces wobble and vibrations.
  • the figures show an embodiment that includes two motors 56a, 56b, this is done for illustrative purposes only. Performance may further be improved by using more than two motors 56a, 56b to enhance the beating effect. In some instances, it may also be possible to produce a desired beating phenomenon use a single motor having a mechanism coupled to the motor’s shaft. Such an arrangement would work more like a car’s gearbox, which increases or reduced the output speed and torque mechanically rather than electronically.
  • a method of drawing capillary blood from the fingertip of a mammalian subject may include promoting blood to pool proximate to or in the vicinity of the drawing site and, moreover, encouraging the pooled blood to flow into the capillaries from which the blood sample will be taken or drawn. Promoting blood to pool proximate to or in the vicinity of the drawing site can include, for example, constricting blood flow in the digit, while encouraging the pooled blood to flow into the capillaries may involve lowering the arterial resistivity index.
  • the previously described device provides each of these desirable qualities.
  • a tourniquet device similar to the one previously described may be provided (STEP 1) and the digit, from whence the capillary blood sample will be drawn, maybe placed in the tourniquet device (STEP 2).
  • FIG. 8 shows a tourniquet device 100 disposed on the middle finger 81 of a subject’s left hand 80.
  • the proximal 82 and middle phalanxes 84 of the subject’s middle finger 81 may be placed in the cradle portion 10 of the device 100 (STEP 2), such that the proximal interphalangeal joint 83 is resting on some portion of the extended rib portion 13.
  • the distal phalanx 86 and distal interphalangeal joint 85 may be substantially out of the cradle portion 10 of the device 100.
  • the biasing element 15 may then be stretched over each of the attachments posts 28, so that the tension in the biasing element 15 restricts (i.e., constricts or partially blocks) blood flow in the middle finger 81 (STEP 3).
  • the rigid ribbed, vibrating plate 11 on which the finger 81 is placed and the more elastic biasing element 15 across the top of the finger 81 constrict or partially block the flow of blood out of the finger 81 without completely cutting off blood supply to the finger 81. Due to the higher arterial blood pressure relative to the lower venous blood pressure and the constriction afforded by the biasing element 15, the rate at which blood enters the finger 81 exceeds the rate at which blood exits the finger 81, causing blood to pool in the finger 81 proximate or in the vicinity of, for example, the distal phalanx 86.
  • Capillaries are extremely tiny blood vessels.
  • low frequency vibrations have been used to promote dilation in capillaries, resulting in more red blood cells entering the capillaries.
  • vibrations that have low frequency and high amplitude typically increase the deformability of the cell walls of red blood cells, making it easier for blood cells to squeeze into a tiny capillary. Accordingly, subjecting the pooling blood to low frequency and/or high amplitude vibrations promotes greater blood flow (STEP 5) into the dilated capillaries.
  • vibrations that have a low frequency and/or a high amplitude lower the arterial resistivity index, i.e., the resistive force that a microvascular bed applies to the blood which is flowing through it, making it easier for blood to flow to areas of the body where there is less blood supply.
  • Low frequency vibrations also cause vasodilation, i.e., a widening of the blood vessels.
  • beating phenomenon also known as beating frequency or simply beats
  • the phenomena by which two high frequencies (e.g. vibratory) waves enforce each other or cancel out each other are referred to, respectively, as constructive interference and destructive interference, which is shown in FIG. 9.
  • the upper displacement versus time relationship (labeled (a)) in FIG. 9 shows two high frequency (e.g., vibratory) waves 92, 94 being overlapped on each other.
  • Typical waves 92, 94 generated by small vibratory motors may be characterized as having slightly different (high) frequencies but having the same or substantially the same relatively high amplitudes.
  • the resultant wave may be characterized as a high amplitude, low frequency wave.
  • the processing device may be adapted to combined two waves 92, 94, such that, in the resultant wave, at certain instances 93, the combined waves 92, 94 cancel each other out, while at other instances 95, the combined waves 92, 94 enforce each other.
  • the net effect of this constructive and destructive interference results in a high amplitude, low frequency wave.
  • the beating phenomenon enables a transfer of energy into the system where low- frequency vibrations can be induced by coupling vibrations from multiple (e.g., two) high- frequency sources.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Percussion Or Vibration Massage (AREA)

Abstract

L'invention concerne un dispositif et un procédé de collecte de sang à partir d'un doigt de mammifère, le dispositif comprenant une partie de berceau rigide structurée et agencée pour retenir le doigt, un premier dispositif de sollicitation pouvant être fixé de manière amovible à la partie de berceau, une partie de boîtier pouvant être reliée de manière amovible à la partie de berceau, et une pluralité de moteurs vibrants situés sous la partie de berceau dans la partie de boîtier, de telle sorte que des vibrations transmises au doigt améliorent la collecte de sang, de telle sorte que le premier dispositif de sollicitation comprime la circulation sanguine vers le point de collecte sur le doigt, amenant le sang à s'accumuler à l'intérieur de celui-ci, et des vibrations à basse fréquence et/ou à amplitude élevée provoquent une vasodilatation, encourageant la circulation sanguine à travers les capillaires au niveau du point de collecte.
PCT/IB2019/000271 2019-03-20 2019-03-20 Garrot vibrant et procédés de collecte de sang l'utilisant WO2020188309A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/IB2019/000271 WO2020188309A1 (fr) 2019-03-20 2019-03-20 Garrot vibrant et procédés de collecte de sang l'utilisant

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PCT/IB2019/000271 WO2020188309A1 (fr) 2019-03-20 2019-03-20 Garrot vibrant et procédés de collecte de sang l'utilisant

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030220663A1 (en) * 2002-05-22 2003-11-27 Fletcher Henry H. Lancet device
US20070083131A1 (en) * 2005-09-30 2007-04-12 Rosedale Medical, Inc. Catalysts for body fluid sample extraction
US20070088385A1 (en) * 2005-10-14 2007-04-19 Perry Eric S Vibrating tourniquet
WO2009081405A2 (fr) * 2007-12-25 2009-07-02 Rapidx Ltd. Dispositifs et procédés de prélèvement de sang provoquant une douleur réduite
US20090177224A1 (en) * 2008-01-07 2009-07-09 In3 Ventures, Inc. Methods and apparatus for blood sampling
US20110118568A1 (en) * 2007-08-31 2011-05-19 Terumo Kabushiki Kaisha Assistance device
US20150257970A1 (en) * 2011-02-17 2015-09-17 Martin Mücke Device and method for reducing pain

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030220663A1 (en) * 2002-05-22 2003-11-27 Fletcher Henry H. Lancet device
US20070083131A1 (en) * 2005-09-30 2007-04-12 Rosedale Medical, Inc. Catalysts for body fluid sample extraction
US20070088385A1 (en) * 2005-10-14 2007-04-19 Perry Eric S Vibrating tourniquet
US20110118568A1 (en) * 2007-08-31 2011-05-19 Terumo Kabushiki Kaisha Assistance device
WO2009081405A2 (fr) * 2007-12-25 2009-07-02 Rapidx Ltd. Dispositifs et procédés de prélèvement de sang provoquant une douleur réduite
US20090177224A1 (en) * 2008-01-07 2009-07-09 In3 Ventures, Inc. Methods and apparatus for blood sampling
US20150257970A1 (en) * 2011-02-17 2015-09-17 Martin Mücke Device and method for reducing pain

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