WO2020184844A3 - 독립적 온도 제어가 가능한 pcr용 블록 - Google Patents

독립적 온도 제어가 가능한 pcr용 블록 Download PDF

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Publication number
WO2020184844A3
WO2020184844A3 PCT/KR2020/001766 KR2020001766W WO2020184844A3 WO 2020184844 A3 WO2020184844 A3 WO 2020184844A3 KR 2020001766 W KR2020001766 W KR 2020001766W WO 2020184844 A3 WO2020184844 A3 WO 2020184844A3
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heat
generating
pcr
chambers
chamber
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Ceased
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PCT/KR2020/001766
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English (en)
French (fr)
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WO2020184844A2 (ko
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이효
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FUTURE ENG CO Ltd
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FUTURE ENG CO Ltd
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Priority to EP20770843.9A priority Critical patent/EP3939703A4/en
Priority to US17/428,228 priority patent/US20220118456A1/en
Priority to CN202080009805.6A priority patent/CN113348239A/zh
Publication of WO2020184844A2 publication Critical patent/WO2020184844A2/ko
Publication of WO2020184844A3 publication Critical patent/WO2020184844A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663—Stretching or orienting elongated molecules or particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Waste-Gas Treatment And Other Accessory Devices For Furnaces (AREA)

Abstract

본 발명은, 독립적 온도 제어가 가능한 PCR용 블록에 관한 것으로서, 더욱 상세하게는, 배열을 이루는 복수의 발열 챔버 상하단을 각각 열과 행으로 구분하여 선택적으로 통전시킬 수 있고, 발열 챔버에 일대일 매칭되도록 온도 측정 센서가 구비됨으로써, 발열 챔버 각각을 독립적으로 정확히 제어할 수 있으며, 인쇄회로기판 형태의 상단 보드와 하단 보드의 사이에 발열체가 코팅된 발열 챔버를 결합하는것만으로 종래의 열 챔버의 대체가 가능하므로, 구조가 단순하고 제조 비용이 저감되고, 상광 하협 형상을 갖는 발열 챔버를 직접 가열하여 내측에 밀착된 튜브 몸체로 직접 열의 전도가 가능하고, 발열 챔버의 열용량이 작아 가열 및 냉각을 빠르게 실시할 수 있어 온도사이클링 시간을 단축시킬 수 있는 다수의 단일 열 챔버를 가진 PCR용 온도 순환 장치를 제공하는데 그 목적이 있다.
PCT/KR2020/001766 2019-03-12 2020-02-07 독립적 온도 제어가 가능한 pcr용 블록 Ceased WO2020184844A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP20770843.9A EP3939703A4 (en) 2019-03-12 2020-02-07 INDEPENDENTLY TEMPERATURE BLOCK FOR PCR
US17/428,228 US20220118456A1 (en) 2019-03-12 2020-02-07 Independently temperature controllable block for pcr
CN202080009805.6A CN113348239A (zh) 2019-03-12 2020-02-07 一种能够独立控制温度的pcr用模块

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020190028389A KR102204931B1 (ko) 2019-03-12 2019-03-12 독립적 온도 제어가 가능한 pcr용 블록
KR10-2019-0028389 2019-03-12

Publications (2)

Publication Number Publication Date
WO2020184844A2 WO2020184844A2 (ko) 2020-09-17
WO2020184844A3 true WO2020184844A3 (ko) 2020-11-05

Family

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PCT/KR2020/001766 Ceased WO2020184844A2 (ko) 2019-03-12 2020-02-07 독립적 온도 제어가 가능한 pcr용 블록

Country Status (5)

Country Link
US (1) US20220118456A1 (ko)
EP (1) EP3939703A4 (ko)
KR (1) KR102204931B1 (ko)
CN (1) CN113348239A (ko)
WO (1) WO2020184844A2 (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR200496780Y1 (ko) * 2021-03-31 2023-04-26 (주)레보스케치 Ｐｃｒ 장치의 히터구조물
KR102543705B1 (ko) * 2021-08-12 2023-06-15 퓨쳐이엔지 주식회사 Pcr 장치
KR102568395B1 (ko) * 2021-09-23 2023-08-21 주식회사 수젠텍 다채널 인큐베이터
KR102748381B1 (ko) * 2021-12-30 2024-12-27 주식회사 수젠텍 인큐베이터 온도 제어 시스템 및 그의 제작방법
KR102661255B1 (ko) * 2021-12-30 2024-04-29 한국전자기술연구원 휴대용 열블록 모듈
KR102821115B1 (ko) 2022-10-04 2025-06-16 한국광기술원 Pcr 유전자 증폭 장치
WO2025163199A1 (en) * 2024-02-01 2025-08-07 Analog Devices International Unlimited Company Methods of amplifying target nucleic acids in a sample
WO2025169030A1 (en) * 2024-02-05 2025-08-14 Corintis Sa Thermal device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060017283A (ko) * 2004-08-20 2006-02-23 삼성테크윈 주식회사 중합효소 연쇄반응 장치
JP2007503217A (ja) * 2003-05-23 2007-02-22 バイオ−ラッド ラボラトリーズ，インコーポレイティド 反応培地の空間配列に対し局部化した温度制御
US20100101237A1 (en) * 2008-10-24 2010-04-29 Quanta Computer Inc. Temperature variation apparatus
US20130078713A1 (en) * 1997-03-28 2013-03-28 Applied Biosystems, Llc Thermal Cycler For PCR
KR20180117454A (ko) * 2017-04-19 2018-10-29 주식회사 넥서스비 휴대용 실시간 pcr 측정기기

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0226863D0 (en) * 2002-11-19 2002-12-24 Biogene Ltd Improvements in and relating to reaction vessels and reaction apparatus for use with such vessels
KR100603821B1 (ko) 2004-03-12 2006-07-26 김진수 고효율 유전자 증폭장치의 웰 온도 제어장치 및 그 제어방법
CN101365996B (zh) * 2005-12-19 2011-06-15 皇家飞利浦电子股份有限公司 有源矩阵温度控制器阵列
GB0610432D0 (en) * 2006-05-26 2006-07-05 B G Res Ltd Performance issues in use of vessels for biological applications
GB0718250D0 (en) * 2007-08-29 2007-10-31 B G Res Ltd Improvements in and relating to reaction apparatus
CN102471746B (zh) * 2009-08-20 2013-07-10 宝生物工程有限公司 温度循环装置
GB201016014D0 (en) * 2010-09-24 2010-11-10 Epistem Ltd Thermal cycler
CN109082422B (zh) * 2018-10-23 2020-07-28 宁波艾捷康宁生物科技有限公司 一种全自动pcr核酸提取检测装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130078713A1 (en) * 1997-03-28 2013-03-28 Applied Biosystems, Llc Thermal Cycler For PCR
JP2007503217A (ja) * 2003-05-23 2007-02-22 バイオ−ラッド ラボラトリーズ，インコーポレイティド 反応培地の空間配列に対し局部化した温度制御
KR20060017283A (ko) * 2004-08-20 2006-02-23 삼성테크윈 주식회사 중합효소 연쇄반응 장치
US20100101237A1 (en) * 2008-10-24 2010-04-29 Quanta Computer Inc. Temperature variation apparatus
KR20180117454A (ko) * 2017-04-19 2018-10-29 주식회사 넥서스비 휴대용 실시간 pcr 측정기기

Also Published As

Publication number Publication date
CN113348239A (zh) 2021-09-03
US20220118456A1 (en) 2022-04-21
KR102204931B1 (ko) 2021-01-20
EP3939703A4 (en) 2023-01-11
EP3939703A2 (en) 2022-01-19
KR20200109187A (ko) 2020-09-22
WO2020184844A2 (ko) 2020-09-17

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