WO2020183771A1 - Solvent consumption management system - Google Patents

Solvent consumption management system Download PDF

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WO2020183771A1
WO2020183771A1 PCT/JP2019/040413 JP2019040413W WO2020183771A1 WO 2020183771 A1 WO2020183771 A1 WO 2020183771A1 JP 2019040413 W JP2019040413 W JP 2019040413W WO 2020183771 A1 WO2020183771 A1 WO 2020183771A1
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solvent
consumption
solvent consumption
liquid chromatography
chromatography analysis
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PCT/JP2019/040413
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French (fr)
Japanese (ja)
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浩志 大橋
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株式会社島津製作所
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Priority to JP2021505492A priority Critical patent/JP7215565B2/en
Publication of WO2020183771A1 publication Critical patent/WO2020183771A1/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns

Definitions

  • the present invention relates to a solvent usage control device in a liquid chromatography analysis system.
  • the solvent used as the mobile phase in the liquid chromatography analysis includes an organic solvent such as methanol or acetonitrile. Considering the impact on the environment, it is desirable that the consumption of these organic solvents be properly controlled. With the technique disclosed in Patent Document 1, it is not possible to control how much a specific solvent such as methanol or acetonitrile is consumed in total.
  • an object of the present invention is to enable the consumption amount of the organic solvent to be appropriately controlled.
  • a solvent consumption management system that is network-connected to a chromatography analysis system and controls the amount of solvent consumed in the liquid chromatography analysis system, wherein the liquid chromatography analysis system is a residue in a container containing the solution.
  • a fuel gauge for detecting the amount is provided, and composition information regarding the composition of the solution used as the mobile phase is acquired from a management device that manages the liquid chromatography analysis system, and the composition information and the fuel gauge are used. It is provided with a solvent consumption calculation unit configured to individually calculate the consumption of at least a solvent containing an organic solvent among the solvents constituting the solution by using the remaining amount of the detected solution.
  • the solvent consumption control system uses the composition information of the solution used as the mobile phase and the remaining amount of the solution detected by the fuel gauge, and is a solvent containing at least an organic solvent among the solvents that compose the solution. Since the solvent consumption calculation unit is provided so as to individually calculate the consumption of the organic solvent, the consumption of the organic solvent in the liquid chromatography analysis system can be appropriately managed.
  • the solvent consumption management system 2 is realized by a computer connected to a plurality of liquid chromatography analysis systems (hereinafter referred to as analysis systems) 10-1 to 10-n via a network line such as an Internet line. To.
  • each analysis system 10-1 to 10-n a sample is injected into an analysis flow path through which a mobile phase flows, and the injected sample is separated by a separation column provided on the analysis flow path to perform chromatographic analysis.
  • Each analysis system 10-1 to 10-n contained elements such as a liquid feed pump, an autosampler, a separation column, and a detector (both not shown), as well as a solution to be fed as a mobile phase by the liquid feed pump.
  • the management device 16 is provided.
  • each analysis system 10-1 to 10-n is depicted as having four fuel gauges 12 and four containers 18, but the number of fuel gauges 12 and containers 18 may be arbitrary. , May be different for each analysis system.
  • the fuel gauge 12 is a weight sensor that measures the weight of the container 18, but any fuel sensor 12 may be used as long as it can measure the remaining amount of the solution in the container 18.
  • the signal of each fuel gauge 12 is taken into the solvent consumption management system 2 via the system controller 14 and the management device 16.
  • the management device 16 is realized by a computer circuit including a central processing unit (CPU), a storage device, and the like.
  • a composition information holding unit 20 is provided in the management device 16 of each analysis system 10-1 to 10-n.
  • the composition information holding unit 20 is a storage area for storing information regarding the composition of the solution contained in each container 18.
  • the user of each analysis system 10-1 to 10-n inputs information regarding the composition of the solution in the container 18 installed on the fuel gauge 12 into the management device 16.
  • the composition information of the solution in the container 18 input by the user is stored in the composition information holding unit 20.
  • the solvent consumption management system 2 includes a solvent consumption calculation unit 4 and an integration period setting unit 6.
  • the solvent consumption calculation unit 4 and the integration period setting unit 6 are functions obtained by the CPU of the solvent consumption management system 2 executing a predetermined program.
  • the solvent consumption calculation unit 4 receives the composition information of each container 18 held in the composition information holding unit 20 of each analysis system 10-1 to 10-n and the composition information of each analysis system 10-1 to 10-n for a certain period of time.
  • the consumption amount for each type of solvent in each analysis system 10-1 to 10-n is calculated by using the signal of each remaining amount meter 12 taken in at intervals, and integrated for each analysis system 10-1 to 10-n. It is configured to do.
  • the integration period setting unit 6 is configured to allow the user to input a period (for example, one month) for accumulating the consumption amount of each solvent, and set the period input by the user as the integration period.
  • the solvent consumption calculation unit 4 is configured to integrate the consumption of each solvent only during the integration period set by the integration period setting unit 6.
  • the consumption of the solution in each container 18 of each analysis system 10-1 to 10-n can be obtained from the difference between the current signal value and the previous signal value of the remaining amount meter 12.
  • the solvent consumption calculation unit 4 obtains the consumption of acetonitrile by multiplying the consumption of the solution by the composition ratio of 0.8.
  • the consumption of water is calculated by multiplying the consumption of the solution by the composition ratio of 0.2.
  • the solvent consumption calculation unit 4 does not necessarily have to calculate the consumption of water, and may be configured to obtain only the consumption of an organic solvent such as methanol or acetonitrile.
  • a plurality of analysis systems 10-1 and 10-2 are installed in a common area 100 (for example, a laboratory) by a common management device 16'. It may be managed comprehensively.
  • the management device 16' has a composition information holding unit 20'that holds the composition information of the solution in the container 18 provided in each of the analysis systems 10-1 and 10-2 managed by the management device 16'. Provided.
  • the signal of the remaining amount meter 12 of each analysis system 10-1 and 10-2 is taken into the solvent consumption management system 2 via the system controller 14 and the management device 16'.
  • the solvent consumption calculation unit 4 of the solvent consumption management system 2 inputs the signal of each remaining amount meter 12 taken in at regular intervals via the management device 16'and the composition information held in the composition information holding unit 20'. It is configured to calculate the consumption amount for each solvent in each analysis system 10-1 and 10-2 and integrate them for a certain period of time.
  • the solvent consumption calculation unit 4 adds up the solvent consumption in the analysis systems 10-1 and 10-2 managed by the common management device 16'for each type of solvent, so that the area is 100 units. It may be configured to calculate the consumption of each solvent of. Then, the amount of organic solvent discharged in 100 units of the area can be comprehensively managed by the solvent consumption management system 2.
  • FIG. 2 shows a configuration in which the two analysis systems 10-1 and 10-2 are managed by the shared management device 16', the analysis system managed by the common management device 16'
  • the number may be any number.
  • the solvent consumption management system 2 takes in the signals of the remaining amount meter 12 of each analysis system 10-1 to 10-n at regular intervals. At a predetermined timing (step 101), the signal of the fuel gauge 12 of each analysis system 10-1 to 10-n is taken into the solvent consumption management system 2 (step 102).
  • the solvent consumption calculation unit 4 takes the difference between the signal value of each remaining amount meter 12 taken in this time and the signal value of each remaining amount meter 12 taken in last time, and changes the amount of change in the remaining amount of the solution in each container 18. (Step 103).
  • the determined amount of change is the amount of solution consumed in each container 18.
  • the solvent consumption calculation unit 4 multiplies the change amount by the composition ratio of each solvent in each solution to obtain the consumption amount of each solvent (step 104), and the consumption amount obtained for each solvent is individually integrated (step 104). Step 105).
  • the area 100 is managed by the management device 16'.
  • the consumption amount of each solvent in a plurality of analysis systems may be added up to obtain the consumption amount of each solvent in 100 units of area.
  • the sample is injected into the analysis flow path through which the mobile phase flows, and the sample is separated for each component by a separation column provided on the analysis flow path.
  • Solvent consumption that controls the amount of solvent consumed in the liquid chromatography analysis system (10-1 to 10-n) by being connected to a network with a liquid chromatography analysis system (10-1 to 10-n) that performs chromatography analysis.
  • the liquid chromatography analysis system (10-1 to 10-n) has a fuel gauge (12) for detecting the remaining amount in the container (18) containing the solution.
  • the composition information regarding the composition of the solution used as the mobile phase is obtained from the control device (16; 16') that manages the liquid chromatography analysis system (10-1 to 10-n).
  • a solvent configured to individually calculate the consumption amount of a solvent containing at least an organic solvent among the solvents constituting the solution, using the remaining amount of the solution detected by the fuel gauge (12). It is equipped with a consumption calculation unit (4).
  • the solvent consumption calculation unit (4) per unit of the remaining amount of the solution detected by the fuel gauge.
  • the consumption amount for each solvent per fixed time is calculated from the amount of change in the above, and the calculated consumption amount for each solvent is integrated for each solvent. According to such an aspect, the consumption amount of each solvent within a certain period can be calculated.
  • the integration period setting unit (6) is provided so as to set the integration period of the solvent consumption based on the user input, and the solvent consumption calculation unit (4) sets the integration period. It may be configured to integrate the consumption amount for each solvent for the integration period set by the part (6). Then, the consumption amount of each solvent within the period desired by the user can be calculated.
  • the fuel gauge (12) is a weight sensor that measures the weight of the container (18).
  • the solvent consumption management system is network-connected to a plurality of liquid chromatography analysis systems (10-1 to 10-n).
  • the solvent consumption calculation unit (4) is configured to calculate the solvent consumption for each liquid chromatography analysis system (10-1 to 10-n). According to such an embodiment, the consumption amount of each solvent can be individually controlled for a plurality of liquid chromatography analysis systems (10-1 to 10-n).
  • control device (16') comprehensively manages a plurality of liquid chromatography analysis systems (10-1, 10-2), and the solvent consumption calculation unit (4). May be configured to calculate the total solvent consumption in a plurality of liquid chromatography analysis systems (10-1, 10-2) controlled by the control device (16'). By doing so, it is possible to control the consumption of each solvent for each specific area (100) in which a plurality of liquid chromatography analysis systems (10-1, 10-2) are installed.
  • Solvent consumption management system 4 Solvent consumption calculation unit 6 Accumulation period setting unit 10-1 to 10-n Liquid chromatography analysis system 12 Remaining meter 14 System controller 16, 16'Management device 18 Container 20, 20' Composition information Holding part

Abstract

A solvent consumption management system (2) is connected via a network to liquid chromatography analysis systems (10-1 to 10-n) in which a sample is introduced into an analysis flow channel in which a mobile phase is flowing, and the sample is separated into components in a separation column provided on the analysis flow channel and is analyzed by chromatography. The solvent consumption management system (2) manages the amount of solvent consumed by the liquid chromatography analysis systems (10-1 to 10-n). The liquid chromatography analysis systems (10-1 to 10-n) are provided with residual amount meters (12) for detecting the residual amount in containers (18) containing the solution. The solvent consumption management system (2) is provided with a solvent consumption calculation unit (4) configured to acquire composition information relating to the composition of a solution used as the mobile phase from management devices (16, 16') for managing the liquid chromatography analysis systems (10-1 to 10-n), and individually calculate the amounts of consumed solvents including at least an organic solvent among solvents constituting the solution using the composition information and the amounts of residual solution detected by the residual amount meters (12).

Description

溶媒消費量管理システムSolvent consumption management system
　本発明は、液体クロマトグラフィー分析システムにおける溶媒使用量の管理装置に関する。 The present invention relates to a solvent usage control device in a liquid chromatography analysis system.
　液体クロマトグラフィー分析では、移動相として種々の溶媒が使用される。特に、分離された試料成分を分画して捕集する分取の用途では大量の溶媒が使用される。分析システム内の溶媒の残量を管理することは、溶媒の発注を効率的に行なって移動相の枯渇によるダウンタイムの軽減を図る上で重要である。そのため、分析システム内の切替バルブの状態と送液ポンプの動作を監視することによって、移動相がどれだけ使用されているかを管理することが提案されている（特許文献１参照。）。 In liquid chromatography analysis, various solvents are used as the mobile phase. In particular, a large amount of solvent is used for the purpose of fractionation and collection of separated sample components. Managing the remaining amount of solvent in the analysis system is important for efficient solvent ordering and reduction of downtime due to mobile phase depletion. Therefore, it has been proposed to control how much the mobile phase is used by monitoring the state of the switching valve in the analysis system and the operation of the liquid feed pump (see Patent Document 1).
特開２０１５－１９４４３４号公報Japanese Unexamined Patent Publication No. 2015-194434
　液体クロマトグラフィー分析において移動相として使用される溶媒には、メタノールやアセトニトリルなどの有機溶媒が含まれる。環境への影響を考慮すれば、それらの有機溶媒の消費量が適切に管理されることが望ましい。特許文献１に開示の技術では、メタノールやアセトニトリルといった特定の溶媒がトータルでどれだけ消費されているかを管理することができない。 The solvent used as the mobile phase in the liquid chromatography analysis includes an organic solvent such as methanol or acetonitrile. Considering the impact on the environment, it is desirable that the consumption of these organic solvents be properly controlled. With the technique disclosed in Patent Document 1, it is not possible to control how much a specific solvent such as methanol or acetonitrile is consumed in total.
　そこで、本発明は、有機溶媒の消費量を適切に管理することができるようにすることを目的とするものである。 Therefore, an object of the present invention is to enable the consumption amount of the organic solvent to be appropriately controlled.
　本発明に係る溶媒消費量管理システムは、移動相の流れる分析流路中に試料を注入し、前記分析流路上に設けられた分離カラムにより試料を成分ごとに分離してクロマトグラフィー分析を行なう液体クロマトグラフィー分析システムとネットワーク接続され、前記液体クロマトグラフィー分析システムにおける溶媒の消費量を管理する溶媒消費量管理システムであって、前記液体クロマトグラフィー分析システムは、前記溶液が収容される容器内の残量を検出する残量計を備え、前記液体クロマトグラフィー分析システムを管理する管理装置から前記移動相として使用される溶液の組成に関する組成情報を取得し、その組成情報、及び、前記残量計により検出される前記溶液の残量を用いて、前記溶液を組成する溶媒のうち少なくとも有機溶媒を含む溶媒の消費量を個別に算出するように構成された溶媒消費量算出部を備えている。 In the solvent consumption control system according to the present invention, a liquid in which a sample is injected into an analysis flow path through which a mobile phase flows, and the sample is separated for each component by a separation column provided on the analysis flow path to perform chromatography analysis. A solvent consumption management system that is network-connected to a chromatography analysis system and controls the amount of solvent consumed in the liquid chromatography analysis system, wherein the liquid chromatography analysis system is a residue in a container containing the solution. A fuel gauge for detecting the amount is provided, and composition information regarding the composition of the solution used as the mobile phase is acquired from a management device that manages the liquid chromatography analysis system, and the composition information and the fuel gauge are used. It is provided with a solvent consumption calculation unit configured to individually calculate the consumption of at least a solvent containing an organic solvent among the solvents constituting the solution by using the remaining amount of the detected solution.
　本発明に係る溶媒消費量管理システムは、移動相として使用される溶液の組成情報と残量計により検出される溶液の残量を用いて、溶液を組成する溶媒のうち少なくとも有機溶媒を含む溶媒の消費量を個別に算出するように構成された溶媒消費量算出部を備えているので、液体クロマトグラフィー分析システムにおける有機溶媒の消費量を適切に管理することができる。 The solvent consumption control system according to the present invention uses the composition information of the solution used as the mobile phase and the remaining amount of the solution detected by the fuel gauge, and is a solvent containing at least an organic solvent among the solvents that compose the solution. Since the solvent consumption calculation unit is provided so as to individually calculate the consumption of the organic solvent, the consumption of the organic solvent in the liquid chromatography analysis system can be appropriately managed.
複数の液体クロマトグラフィー分析システムにおける溶媒の消費量を管理する溶媒消費量管理システムの一実施例を示す概略構成図である。It is a schematic block diagram which shows an Example of the solvent consumption management system which manages the solvent consumption in a plurality of liquid chromatography analysis systems. 同一エリア内に配設された複数の液体クロマトグラフィー分析システムの溶媒の消費量を管理する溶媒消費量管理システムの一実施例を示す概略構成図である。It is a schematic block diagram which shows an Example of the solvent consumption management system which manages the solvent consumption of a plurality of liquid chromatography analysis systems arranged in the same area. 各溶媒の消費量の管理動作の一例を示すフローチャートである。It is a flowchart which shows an example of the management operation of the consumption amount of each solvent.
　以下、図面を参照しながら、液体クロマトグラフィー分析システムの溶媒消費量管理システムの実施形態について説明する。 Hereinafter, embodiments of the solvent consumption control system of the liquid chromatography analysis system will be described with reference to the drawings.
　溶媒消費量管理システム２は、例えばインターネット回線などのネットワーク回線を介して、複数の液体クロマトグラフィー分析システム（以下、分析システムと称する）１０－１～１０－ｎとネットワーク接続されたコンピュータにより実現される。 The solvent consumption management system 2 is realized by a computer connected to a plurality of liquid chromatography analysis systems (hereinafter referred to as analysis systems) 10-1 to 10-n via a network line such as an Internet line. To.
　各分析システム１０－１～１０－ｎは、移動相の流れる分析流路中に試料を注入し、注入された試料を分析流路上に設けられた分離カラムで分離してクロマトグラフィー分析を行なうためのシステムである。各分析システム１０－１～１０－ｎは、送液ポンプ、オートサンプラ、分離カラム、検出器（ともに図示は省略）といった要素のほか、送液ポンプにより移動相として送液される溶液を収容した容器１８、容器１８内の溶液の残量を検出するための残量計１２、送液ポンプ、オートサンプラ、分離カラム、検出器の動作管理を行なうシステムコントローラ１４、システムコントローラ１４と通信可能に接続された管理装置１６を備えている。 In each analysis system 10-1 to 10-n, a sample is injected into an analysis flow path through which a mobile phase flows, and the injected sample is separated by a separation column provided on the analysis flow path to perform chromatographic analysis. System. Each analysis system 10-1 to 10-n contained elements such as a liquid feed pump, an autosampler, a separation column, and a detector (both not shown), as well as a solution to be fed as a mobile phase by the liquid feed pump. Communicatably connected to the container 18, the fuel gauge 12 for detecting the remaining amount of the solution in the container 18, the liquid feed pump, the autosampler, the separation column, the system controller 14 for managing the operation of the detector, and the system controller 14. The management device 16 is provided.
　図１では、各分析システム１０－１～１０－ｎが４つの残量計１２と４つの容器１８を備えているように描かれているが、残量計１２及び容器１８の数はいくらでもよく、分析システムごとに異なっていてよい。この実施例において、残量計１２は容器１８の重量を計測する重量センサであるが、容器１８内の溶液の残量を計測できるものであればいかなるものであってもよい。各残量計１２の信号はシステムコントローラ１４、管理装置１６を介して溶媒消費量管理システム２に取り込まれる。管理装置１６は、中央演算装置（ＣＰＵ）や記憶装置などを備えたコンピュータ回路によって実現される。 In FIG. 1, each analysis system 10-1 to 10-n is depicted as having four fuel gauges 12 and four containers 18, but the number of fuel gauges 12 and containers 18 may be arbitrary. , May be different for each analysis system. In this embodiment, the fuel gauge 12 is a weight sensor that measures the weight of the container 18, but any fuel sensor 12 may be used as long as it can measure the remaining amount of the solution in the container 18. The signal of each fuel gauge 12 is taken into the solvent consumption management system 2 via the system controller 14 and the management device 16. The management device 16 is realized by a computer circuit including a central processing unit (CPU), a storage device, and the like.
　各分析システム１０－１～１０－ｎの管理装置１６には組成情報保持部２０が設けられている。組成情報保持部２０は、各容器１８に収容されている溶液の組成に関する情報を記憶する記憶領域である。各分析システム１０－１～１０－ｎのユーザは、残量計１２上に設置する容器１８内の溶液の組成に関する情報を管理装置１６に入力する。ユーザにより入力された容器１８内の溶液の組成情報が組成情報保持部２０に記憶される。 A composition information holding unit 20 is provided in the management device 16 of each analysis system 10-1 to 10-n. The composition information holding unit 20 is a storage area for storing information regarding the composition of the solution contained in each container 18. The user of each analysis system 10-1 to 10-n inputs information regarding the composition of the solution in the container 18 installed on the fuel gauge 12 into the management device 16. The composition information of the solution in the container 18 input by the user is stored in the composition information holding unit 20.
　溶媒消費量管理システム２は、溶媒消費量算出部４及び積算期間設定部６を備えている。溶媒消費量算出部４及び積算期間設定部６は、溶媒消費量管理システム２のＣＰＵが所定のプログラムを実行することにより得られる機能である。 The solvent consumption management system 2 includes a solvent consumption calculation unit 4 and an integration period setting unit 6. The solvent consumption calculation unit 4 and the integration period setting unit 6 are functions obtained by the CPU of the solvent consumption management system 2 executing a predetermined program.
　溶媒消費量算出部４は、各分析システム１０－１～１０－ｎの組成情報保持部２０に保持されている各容器１８の組成情報と、各分析システム１０－１～１０－ｎから一定時間間隔で取り込まれる各残量計１２の信号とを用いて、各分析システム１０－１～１０－ｎにおける溶媒の種類ごとの消費量を算出し、分析システム１０－１～１０－ｎごとに積算するように構成されている。 The solvent consumption calculation unit 4 receives the composition information of each container 18 held in the composition information holding unit 20 of each analysis system 10-1 to 10-n and the composition information of each analysis system 10-1 to 10-n for a certain period of time. The consumption amount for each type of solvent in each analysis system 10-1 to 10-n is calculated by using the signal of each remaining amount meter 12 taken in at intervals, and integrated for each analysis system 10-1 to 10-n. It is configured to do.
　積算期間設定部６は、各溶媒の消費量を積算すべき期間（例えば、１か月）をユーザに入力させ、ユーザによって入力された期間を積算期間として設定するように構成されている。溶媒消費量算出部４は、積算期間設定部６により設定された積算期間だけ各溶媒の消費量を積算するように構成されている。 The integration period setting unit 6 is configured to allow the user to input a period (for example, one month) for accumulating the consumption amount of each solvent, and set the period input by the user as the integration period. The solvent consumption calculation unit 4 is configured to integrate the consumption of each solvent only during the integration period set by the integration period setting unit 6.
　各分析システム１０－１～１０－ｎの各容器１８内の溶液の消費量は、残量計１２の今回の信号値と前回の信号値との差分により求めることができる。ある容器１８内の溶液の組成がアセトニトリル：水＝８：２である場合、溶媒消費量算出部４は、その溶液の消費量に組成比率０．８を乗ずることによってアセトニトリルの消費量を求め、その溶液の消費量に組成比率０．２を乗ずることによって水の消費量を求める。なお、溶媒消費量算出部４は、必ずしも水の消費量を算出する必要はなく、メタノールやアセトニトリルといった有機溶媒の消費量のみを求めるように構成されていてもよい。 The consumption of the solution in each container 18 of each analysis system 10-1 to 10-n can be obtained from the difference between the current signal value and the previous signal value of the remaining amount meter 12. When the composition of the solution in a certain container 18 is acetonitrile: water = 8: 2, the solvent consumption calculation unit 4 obtains the consumption of acetonitrile by multiplying the consumption of the solution by the composition ratio of 0.8. The consumption of water is calculated by multiplying the consumption of the solution by the composition ratio of 0.2. The solvent consumption calculation unit 4 does not necessarily have to calculate the consumption of water, and may be configured to obtain only the consumption of an organic solvent such as methanol or acetonitrile.
　また、図２に示されているように、複数の分析システム１０－１、１０－２が共通のエリア１００（例えば、研究所）内に設置されるなどして、共通の管理装置１６’によって統括的に管理されていることがある。管理装置１６’には、当該管理装置１６’によって管理されている各分析システム１０－１、１０－２に設けられている容器１８内の溶液の組成情報を保持する組成情報保持部２０’が設けられる。 Further, as shown in FIG. 2, a plurality of analysis systems 10-1 and 10-2 are installed in a common area 100 (for example, a laboratory) by a common management device 16'. It may be managed comprehensively. The management device 16' has a composition information holding unit 20'that holds the composition information of the solution in the container 18 provided in each of the analysis systems 10-1 and 10-2 managed by the management device 16'. Provided.
　上記の場合、溶媒消費量管理システム２には、各分析システム１０－１、１０－２の残量計１２の信号がシステムコントローラ１４及び管理装置１６’を介して取り込まれる。溶媒消費量管理システム２の溶媒消費量算出部４は、管理装置１６’を介して一定時間ごとに取り込まれる各残量計１２の信号と組成情報保持部２０’に保持されている組成情報を用いて、各分析システム１０－１、１０－２における溶媒ごとの消費量を算出し、一定期間積算するように構成されている。 In the above case, the signal of the remaining amount meter 12 of each analysis system 10-1 and 10-2 is taken into the solvent consumption management system 2 via the system controller 14 and the management device 16'. The solvent consumption calculation unit 4 of the solvent consumption management system 2 inputs the signal of each remaining amount meter 12 taken in at regular intervals via the management device 16'and the composition information held in the composition information holding unit 20'. It is configured to calculate the consumption amount for each solvent in each analysis system 10-1 and 10-2 and integrate them for a certain period of time.
　また、溶媒消費量算出部４は、共通の管理装置１６’によって管理されている分析システム１０－１、１０－２における溶媒の消費量を溶媒の種類ごとに合算することにより、エリア１００単位での各溶媒の消費量を算出するように構成されていてもよい。そうすれば、エリア１００単位での有機溶媒の排出量を溶媒消費量管理システム２において統括的に管理することができる。 In addition, the solvent consumption calculation unit 4 adds up the solvent consumption in the analysis systems 10-1 and 10-2 managed by the common management device 16'for each type of solvent, so that the area is 100 units. It may be configured to calculate the consumption of each solvent of. Then, the amount of organic solvent discharged in 100 units of the area can be comprehensively managed by the solvent consumption management system 2.
　なお、図２では、２台の分析システム１０－１、１０－２が共有の管理装置１６’によって管理される構成が示されているが、共通の管理装置１６’によって管理される分析システムの台数は何台でもよい。 Although FIG. 2 shows a configuration in which the two analysis systems 10-1 and 10-2 are managed by the shared management device 16', the analysis system managed by the common management device 16' The number may be any number.
　以下、図１及び図２に示された実施例における溶媒消費量の管理動作について、図３のフローチャートを用いて説明する。 Hereinafter, the solvent consumption management operation in the examples shown in FIGS. 1 and 2 will be described with reference to the flowchart of FIG.
　溶媒消費量管理システム２には、一定時間ごとに各分析システム１０－１～１０－ｎの残量計１２の信号が取り込まれる。所定のタイミングになると（ステップ１０１）、各分析システム１０－１～１０－ｎの残量計１２の信号が溶媒消費量管理システム２に取り込まれる（ステップ１０２）。溶媒消費量算出部４は、今回取り込まれた各残量計１２の信号値と前回取り込まれた各残量計１２の信号値の差分を取り、各容器１８内の溶液の残量の変化量を求める（ステップ１０３）。求めた変化量は、各容器１８内の溶液の消費量である。溶媒消費量算出部４は、それらの変化量に各溶液における各溶媒の組成比率を乗じて各溶媒の消費量を求め（ステップ１０４）、溶媒ごとに求めた消費量をそれぞれ個別に積算する（ステップ１０５）。 The solvent consumption management system 2 takes in the signals of the remaining amount meter 12 of each analysis system 10-1 to 10-n at regular intervals. At a predetermined timing (step 101), the signal of the fuel gauge 12 of each analysis system 10-1 to 10-n is taken into the solvent consumption management system 2 (step 102). The solvent consumption calculation unit 4 takes the difference between the signal value of each remaining amount meter 12 taken in this time and the signal value of each remaining amount meter 12 taken in last time, and changes the amount of change in the remaining amount of the solution in each container 18. (Step 103). The determined amount of change is the amount of solution consumed in each container 18. The solvent consumption calculation unit 4 multiplies the change amount by the composition ratio of each solvent in each solution to obtain the consumption amount of each solvent (step 104), and the consumption amount obtained for each solvent is individually integrated (step 104). Step 105).
　ここで、図２のように、あるエリア１００において複数の分析システムが共通の管理装置１６’によって統括的に管理されている場合は、そのエリア１００については、管理装置１６’によって管理されている複数の分析システムにおける各溶媒の消費量を足し合わせてエリア１００単位での各溶媒の消費量を求めてもよい。 Here, as shown in FIG. 2, when a plurality of analysis systems are collectively managed by a common management device 16'in a certain area 100, the area 100 is managed by the management device 16'. The consumption amount of each solvent in a plurality of analysis systems may be added up to obtain the consumption amount of each solvent in 100 units of area.
　以上において説明した実施例は、本発明に係る溶媒消費量管理システムの実施形態の例示に過ぎない。本発明に係る溶媒消費量管理システムの実施形態は、以下のとおりである。 The examples described above are merely examples of embodiments of the solvent consumption management system according to the present invention. The embodiment of the solvent consumption management system according to the present invention is as follows.
　本発明に係る溶媒消費量管理システム（２）の実施形態は、移動相の流れる分析流路中に試料を注入し、前記分析流路上に設けられた分離カラムにより試料を成分ごとに分離してクロマトグラフィー分析を行なう液体クロマトグラフィー分析システム（１０－１～１０－ｎ）とネットワーク接続され、前記液体クロマトグラフィー分析システム（１０－１～１０－ｎ）における溶媒の消費量を管理する溶媒消費量管理システム（２）であって、前記液体クロマトグラフィー分析システム（１０－１～１０－ｎ）は、前記溶液が収容される容器（１８）内の残量を検出する残量計（１２）を備え、前記液体クロマトグラフィー分析システム（１０－１～１０－ｎ）を管理する管理装置（１６；１６’）から前記移動相として使用される溶液の組成に関する組成情報を取得し、その組成情報、及び、前記残量計（１２）により検出される前記溶液の残量を用いて、前記溶液を組成する溶媒のうち少なくとも有機溶媒を含む溶媒の消費量を個別に算出するように構成された溶媒消費量算出部（４）を備えている。 In the embodiment of the solvent consumption control system (2) according to the present invention, the sample is injected into the analysis flow path through which the mobile phase flows, and the sample is separated for each component by a separation column provided on the analysis flow path. Solvent consumption that controls the amount of solvent consumed in the liquid chromatography analysis system (10-1 to 10-n) by being connected to a network with a liquid chromatography analysis system (10-1 to 10-n) that performs chromatography analysis. In the management system (2), the liquid chromatography analysis system (10-1 to 10-n) has a fuel gauge (12) for detecting the remaining amount in the container (18) containing the solution. The composition information regarding the composition of the solution used as the mobile phase is obtained from the control device (16; 16') that manages the liquid chromatography analysis system (10-1 to 10-n). A solvent configured to individually calculate the consumption amount of a solvent containing at least an organic solvent among the solvents constituting the solution, using the remaining amount of the solution detected by the fuel gauge (12). It is equipped with a consumption calculation unit (4).
　本発明に係る溶媒消費量管理装置（２）の上記実施形態の第１態様では、前記溶媒消費量算出部（４）は、前記残量計により検出される前記溶液の残量の一定時間当たりの変化量から溶媒ごとの一定時間当たりの消費量を算出し、算出した溶媒ごとの消費量を溶媒ごとに積算するように構成されている。このような態様により、一定期間内における各溶媒の消費量を算出することができる。 In the first aspect of the above embodiment of the solvent consumption management device (2) according to the present invention, the solvent consumption calculation unit (4) per unit of the remaining amount of the solution detected by the fuel gauge. The consumption amount for each solvent per fixed time is calculated from the amount of change in the above, and the calculated consumption amount for each solvent is integrated for each solvent. According to such an aspect, the consumption amount of each solvent within a certain period can be calculated.
　上記第１態様において、溶媒の消費量の積算期間をユーザ入力に基づいて設定するように構成された積算期間設定部（６）を備え、前記溶媒消費量算出部（４）は前記積算期間設定部（６）により設定された積算期間だけ溶媒ごとの消費量を溶媒ごとに積算するように構成されていてもよい。そうすれば、ユーザが所望する期間内における各溶媒の消費量を算出することができる。 In the first aspect, the integration period setting unit (6) is provided so as to set the integration period of the solvent consumption based on the user input, and the solvent consumption calculation unit (4) sets the integration period. It may be configured to integrate the consumption amount for each solvent for the integration period set by the part (6). Then, the consumption amount of each solvent within the period desired by the user can be calculated.
　本発明に係る溶媒消費量管理装置（２）の上記実施形態の第２態様では、前記残量計（１２）は前記容器（１８）の重量を計測する重量センサである。 In the second aspect of the above embodiment of the solvent consumption management device (2) according to the present invention, the fuel gauge (12) is a weight sensor that measures the weight of the container (18).
　本発明に係る溶媒消費量管理装置（２）の上記実施形態の第３態様では、前記溶媒消費量管理システムは複数の液体クロマトグラフィー分析システム（１０－１～１０－ｎ）とネットワーク接続されており、前記溶媒消費量算出部（４）は、液体クロマトグラフィー分析システム（１０－１～１０－ｎ）ごとの溶媒の消費量を算出するように構成されている。このような態様により、複数の液体クロマトグラフィー分析システム（１０－１～１０－ｎ）について溶媒ごとの消費量を個別に管理することができる。 In the third aspect of the above embodiment of the solvent consumption management device (2) according to the present invention, the solvent consumption management system is network-connected to a plurality of liquid chromatography analysis systems (10-1 to 10-n). The solvent consumption calculation unit (4) is configured to calculate the solvent consumption for each liquid chromatography analysis system (10-1 to 10-n). According to such an embodiment, the consumption amount of each solvent can be individually controlled for a plurality of liquid chromatography analysis systems (10-1 to 10-n).
　上記第３態様において、前記管理装置（１６’）は、複数の液体クロマトグラフィー分析システム（１０－１、１０－２）を統括的に管理するものであり、前記溶媒消費量算出部（４）は、前記管理装置（１６’）によって管理されている複数の液体クロマトグラフィー分析システム（１０－１、１０－２）における溶媒の合計消費量を算出するように構成されていてもよい。そうすれば、複数の液体クロマトグラフィー分析システム（１０－１、１０－２）が設置されている特定のエリア（１００）ごとの各溶媒の消費量を管理することができる。 In the third aspect, the control device (16') comprehensively manages a plurality of liquid chromatography analysis systems (10-1, 10-2), and the solvent consumption calculation unit (4). May be configured to calculate the total solvent consumption in a plurality of liquid chromatography analysis systems (10-1, 10-2) controlled by the control device (16'). By doing so, it is possible to control the consumption of each solvent for each specific area (100) in which a plurality of liquid chromatography analysis systems (10-1, 10-2) are installed.
　　　２　　　溶媒消費量管理システム
　　　４　　　溶媒消費量算出部
　　　６　　　積算期間設定部
　　　１０－１～１０－ｎ　　　液体クロマトグラフィー分析システム
　　　１２　　　残量計
　　　１４　　　システムコントローラ
　　　１６，１６’　　　管理装置
　　　１８　　　容器
　　　２０，２０’　　　組成情報保持部 2 Solvent consumption management system 4 Solvent consumption calculation unit 6 Accumulation period setting unit 10-1 to 10-n Liquid chromatography analysis system 12 Remaining meter 14 System controller 16, 16'Management device 18 Container 20, 20' Composition information Holding part

Claims (7)

  1. 　移動相の流れる分析流路中に試料を注入し、前記分析流路上に設けられた分離カラムにより試料を成分ごとに分離してクロマトグラフィー分析を行なう液体クロマトグラフィー分析システムとネットワーク接続され、前記液体クロマトグラフィー分析システムにおける溶媒の消費量を管理する溶媒消費量管理システムであって、
    　前記液体クロマトグラフィー分析システムは、前記溶液が収容される容器内の残量を検出する残量計を備え、
    　前記液体クロマトグラフィー分析システムを管理する管理装置から前記移動相として使用される溶液の組成に関する組成情報を取得し、その組成情報、及び、前記残量計により検出される前記溶液の残量を用いて、前記溶液を組成する溶媒のうち少なくとも有機溶媒を含む溶媒の消費量を個別に算出するように構成された溶媒消費量算出部を備えている、溶媒消費量管理システム。     The sample is injected into the analysis flow path through which the mobile phase flows, and the sample is separated for each component by a separation column provided on the analysis flow path and connected to a network with a liquid chromatography analysis system for performing chromatographic analysis. A solvent consumption control system that controls the amount of solvent consumed in a chromatography analysis system.
    The liquid chromatography analysis system includes a fuel gauge that detects the remaining amount in a container containing the solution.
    Composition information regarding the composition of the solution used as the mobile phase is obtained from the management device that manages the liquid chromatography analysis system, and the composition information and the remaining amount of the solution detected by the fuel gauge are used. A solvent consumption management system comprising a solvent consumption calculation unit configured to individually calculate the consumption of a solvent containing at least an organic solvent among the solvents constituting the solution.
  2. 　前記溶媒消費量算出部は、前記残量計により検出される前記溶液の残量の一定時間当たりの変化量から溶媒ごとの一定時間当たりの消費量を算出し、算出した溶媒ごとの消費量を溶媒ごとに積算するように構成されている、請求項１に記載の溶媒消費量管理システム。 The solvent consumption calculation unit calculates the consumption amount per solvent for each solvent from the amount of change in the remaining amount of the solution detected by the fuel gauge, and calculates the consumption amount for each solvent. The solvent consumption management system according to claim 1, which is configured to integrate for each solvent.
  3. 　溶媒の消費量の積算期間をユーザ入力に基づいて設定するように構成された積算期間設定部を備え、
    　前記溶媒消費量算出部は前記積算期間設定部により設定された積算期間だけ溶媒ごとの消費量を溶媒ごとに積算するように構成されている、請求項２に記載の溶媒消費量管理システム。     It is provided with an integration period setting unit configured to set the integration period of solvent consumption based on user input.
    The solvent consumption management system according to claim 2, wherein the solvent consumption calculation unit is configured to integrate the consumption amount for each solvent for the integration period set by the integration period setting unit.
  4. 　前記残量計は前記容器の重量を計測する重量センサである、請求項１に記載の溶媒消費量管理システム。 The solvent consumption management system according to claim 1, wherein the fuel gauge is a weight sensor that measures the weight of the container.
  5. 　前記溶媒消費量管理システムは複数の液体クロマトグラフィー分析システムとネットワーク接続されており、
    　前記溶媒消費量算出部は、液体クロマトグラフィー分析システムごとの溶媒の消費量を算出するように構成されている、請求項１に記載の溶媒消費量管理システム。     The solvent consumption control system is networked with a plurality of liquid chromatography analysis systems.
    The solvent consumption management system according to claim 1, wherein the solvent consumption calculation unit is configured to calculate the solvent consumption for each liquid chromatography analysis system.
  6. 　前記管理装置は、複数の液体クロマトグラフィー分析システムを統括的に管理するものであり、
    　前記溶媒消費量算出部は、前記管理装置によって管理されている複数の液体クロマトグラフィー分析システムにおける溶媒の合計消費量を算出するように構成されている、請求項５に記載の溶媒消費量管理システム。     The management device comprehensively manages a plurality of liquid chromatography analysis systems.
    The solvent consumption management system according to claim 5, wherein the solvent consumption calculation unit is configured to calculate the total consumption of solvents in a plurality of liquid chromatography analysis systems managed by the management device. ..
  7. 　前記溶媒消費量算出部は、エリア単位での各溶媒の消費量を算出するように構成されている、請求項１に記載の溶媒消費量管理システム。 The solvent consumption management system according to claim 1, wherein the solvent consumption calculation unit is configured to calculate the consumption of each solvent in each area.
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