WO2020171688A1 - Machine de mélange par ultrasons - Google Patents

Machine de mélange par ultrasons Download PDF

Info

Publication number
WO2020171688A1
WO2020171688A1 PCT/MX2019/000050 MX2019000050W WO2020171688A1 WO 2020171688 A1 WO2020171688 A1 WO 2020171688A1 MX 2019000050 W MX2019000050 W MX 2019000050W WO 2020171688 A1 WO2020171688 A1 WO 2020171688A1
Authority
WO
WIPO (PCT)
Prior art keywords
tank
machine
ultrasound
cover
mixing
Prior art date
Application number
PCT/MX2019/000050
Other languages
English (en)
Spanish (es)
Inventor
Andrés Abelino CHOZA ROMERO
Original Assignee
Bioactivos Y Nutracéuticos De México S.A. De C.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioactivos Y Nutracéuticos De México S.A. De C.V. filed Critical Bioactivos Y Nutracéuticos De México S.A. De C.V.
Publication of WO2020171688A1 publication Critical patent/WO2020171688A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90—Heating or cooling systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations

Definitions

  • the present invention is related to the technical field of mechanics, electronics, chemistry, thermodynamics and the transformation of matter, since it provides a machine for mixing by means of ultrasound.
  • Mixing is the process in which various ingredients are brought into contact, in such a way that at the end of the operation, a homogeneous system is obtained at a certain scale (from molecular to macroscopic). Depending on the scale of the mixing and the relative miscibility of the substances in the presence, the result can be a solution, a colloid or a micro or macroscopic dispersion: emulsion, suspension or foam.
  • the materials are introduced by means of a pump and the mixture is produced by interference of their current flows. They are only used in continuous or circulating systems for the complete mixing of miscible fluids.
  • the turbine can have a guide ring with fixed curved blades (diffusers) that deflect these tangential currents until they become radial.
  • the desired effects of ultrasound of liquids are caused by cavitation.
  • high-power ultrasound By introducing high-power ultrasound into a liquid medium, sound waves are transmitted through the fluid and create alternating cycles of high pressure (compression) and low pressure (rarefaction), with velocities that depend on frequency.
  • the high intensity ultrasonic waves create small vacuum bubbles or voids in the liquid. When the bubbles reach a volume where they can no longer absorb energy, they collapse violently during a high pressure cycle. This phenomenon is called cavitation.
  • Ultrasound can be very mild and delicate or very intense; the input power of the ultrasonicator can be adjusted by adjusting the ultrasonic power between 20% and 100% depending on the formulation and the goal of the process.
  • the electronic vaporization device may comprise a vaporization component having an ultrasonic vibrating element that can function to produce ultrasonic vibrations to vaporize at least a portion of the vaporizable material received therein.
  • the vaporization component may further comprise a heating element operable to produce thermal energy to vaporize at least a portion of the vaporizable material received therein.
  • the electronic vaporization device may comprise a processor operable to generate at least one vaporization control signal to selectively operate at least one of the ultrasonic vibrating element and the heating element. The operation of the vaporization component can be determined by a user or a third party through a remote device and the like.
  • the transducer is a broadband ultrasound transducer.
  • the apparatus further includes a voltage control oscillator, adapted to send an excitation signal to said transducer through a complex resistor, in said oscillator and said microprocessor defining the frequency of the excitation signal of the transducer, including an amplitude detector or phase adapted to receive the driving signal of the complex resistor, and further adapted to provide a feedback signal to said microprocessor indicating changes in the electrical impedance of the transducer in the area of said resonance frequencies.
  • settling time for dilute suspensions shows a peak at different settling times for suspensions that have different properties, and the location of this peak is used as a mechanism to characterize suspensions.
  • a plurality of ultrasound receivers are arranged at different angles to a common transmitter to receive scattering responses at a variety of angles during particle settling. Angular differences in dispersion as a function of settling time are also used to characterize the suspension.
  • none of the aforementioned documents is there information on being able to remove the upper lid of the container by means of a hydraulic system or pulleys with counterweight; adding that there is no reference to having a vaporizer made up of a variety of piezoelectrics. None of the cited documents documents information about having a pressurizer for the vaporization of higher density assets.
  • Figure 1 shows a top perspective view of the machine for mixing by means of ultrasound.
  • Figure 2 shows a front view of the machine for mixing by means of ultrasound.
  • Figure 3 shows a right side view of the machine for mixing by means of ultrasound.
  • Figure 4 shows a front view of the coil of the machine for mixing by means of ultrasound.
  • Figure 5 shows a top perspective view of the coil of the machine for mixing by means of ultrasound.
  • Figure 6 shows a side view of the tank of the machine for mixing by means of ultrasound.
  • Figure 7 shows a top perspective view of the tank of the machine for mixing by means of ultrasound.
  • Figure 8 shows a bottom perspective view of the inlet of the lower agitator of the machine for mixing by means of ultrasound.
  • Figure 9 shows a top perspective view of the secondary agitator of the machine for mixing by means of ultrasound.
  • Figure 10 shows a top perspective view of the lid seal of the machine for mixing by means of ultrasound.
  • Figure 11 shows a top perspective view of the lid of the machine for mixing by means of ultrasound.
  • Figure 12 shows a top perspective view of the main agitator of the machine for mixing by means of ultrasound.
  • Figure 13 shows a top perspective view of the structure of the machine for mixing by means of ultrasound.
  • Figure 14 shows a front cross-sectional view of the bottom of the tank of the machine for mixing by means of ultrasound.
  • Figure 15 shows a top view of the piezoelectric of the ultrasonic unit of the machine for mixing by means of ultrasound.
  • the ultrasound mixing machine is made up of a tank (1) preferably made of 316 stainless steel with a cylindrical shape and a concave bottom, this configuration allows a total and more efficient drainage of substances introduced into the tank (1);
  • a coil (2) is installed outside the tank (1) in its lower part and is configured to allow the circulation of water at a temperature controlled by a heater (3), where, by means of a solenoid valve (4) increases or decreases the water flow if the set temperature increases or decreases.
  • a jacket (5) with thermal insulation is spherical and concave in shape, and is arranged on the outside of the tank (1) covering the part where the coil (2) is located, configured to avoid the contact of the operator with said coil (2) and prevent injuries due to low and / or high operating temperatures, as well as maintaining the desired temperature without loss.
  • a discharge mechanism (6) is installed in the lower part of the tank (1) crossing it from the inside to the outside of the jacket (5), said discharge mechanism preferably has a clamp-type connection (7) on the outside;
  • a discharge valve (8) that can be ball, gate, diaphragm or butterfly, is installed in the end of the discharge mechanism (6) that is exposed, by means of a clamp type clamp (not illustrated), this configuration allows the draining of substances from the tank (1) when the discharge valve (8) is open, or to keep substances inside the tank (1) when said discharge valve (8) is closed.
  • a drain pump (38) is installed on the discharge valve (8), and is configured to speed up the drainage of the product that is inside the tank (1) and / or to be able to take the product to other tanks with greater height.
  • An inlet for the secondary agitator (9), which is cylindrical in shape, is installed in the lower part of the tank (1) through it from the inside to the outside of the jacket (5), where the part that is in the interior of the tank (1) has several perforations (10) on its circumference, configured to allow the circulation of the solution introduced to the tank (1) and facilitates its homogenization, and on the outside it has a clamp type connection installed (not illustrated) , arranged for the installation of a secondary agitator (11), which is configured so that the homogenization of the solutions found at the bottom of the tank (1) is more efficient, in less time and to avoid the settlement of the solution.
  • the secondary agitator (11) is connected to a secondary motor (12) for its operation by means of a mechanical seal (not illustrated), configured to avoid spillage of the solution that is inside the tank (1); said secondary motor (12) is preferably electric.
  • the mechanical seal can be made of carbon, ceramic, stainless steel or silicon carbide.
  • the tank (1) has at least one register (13) positioned so that it passes through the lower part of the tank (1) to the outside of the jacket (5), the registers (3) are configured to install different measuring instruments (not illustrated).
  • At least two supports (14) are arranged on the sides of the tank (1), configured to be fixed in a structure (15), which supports all the components of the machine to mix by means of ultrasound;
  • Said structure is preferably made of a rectangular tubular stainless steel profile.
  • a lid (17) with a food grade seal (18) is configured to hermetically close the upper part of the tank (1), the hermetic closure is maintained by means of, at least, two fastening means (16), the which are preferably mechanical clamps that are arranged outside the upper circumference of the tank (1) and the lid (17).
  • At least one instrument connection (19) is installed in the upper part of the cover (17), configured to install different measuring instruments (not illustrated).
  • At least one peephole (20) is arranged in the upper part of the lid (17) configured to view inside the tank (1); at least one lighting socket (21) is installed in the upper part of the cover
  • a base (22) made up of three walls and a shelf (40) is installed in the upper part of the cover (17), the rear wall of the base (22) and the shelf (40) have perforations on which A main motor (23) is fixed and installed that has a gear motor (24) arranged, configured to install a main agitator (25) that passes through the cover (17) and is assembled by means of a flexible copy (26) configured to minimize alignment variations, this configuration allows for the homogeneous mixing of different solutions.
  • the structure (15) has on its rear part at the height of the tank (1) with a post (41) positioned perpendicular to said structure (15), said post (41) has at its end a winch (42) with a crank (29) on which a cable (43) is entangled that is tied to a counterweight (28) and to a set of pulleys (27) placed in the upper part of the structure (15), to later fix to the base (22) said cable (43), this configuration allows removing the cover (17) in a more efficient way.
  • the cap (17) can also be removed by means of a pneumatic system (not illustrated).
  • An ultrasonic unit (30) is installed on one side of the structure (15), said unit has at least one piezoelectric (31) configured to generate a high frequency and low intensity vibration for mixtures that is not required. Modification of the molecular structure of the components or the ultrasonic unit (30) can generate a high-frequency vibration with high intensity for when fractionation of the mixed molecule is required, thereby allowing a liquid solution to be vaporized, generating microparticles or vapor of the liquid solution, which allows optimizing the adherence of said solution with the excipient found inside the tank (1) and generating a homogeneous mixture.
  • a steam outlet (32) is installed in the upper part of the ultrasonic unit (30), arranged to pass the active microparticles in a vapor state, through a feed tube (33) into the tank ( 1) by means of a steam inlet (34) placed on the cover (17);
  • the feed tube (33) is connected to the steam inlet (34) by means of a clamp type (not illustrated).
  • a pressurizer (35) is installed in the lateral part of the structure (15), and is arranged to fractionate higher density actives, which cannot be fractionated by ultrasound.
  • the pressurizer (35) is configured to introduce an asset into its interior and by means of an inert gas, preferably nitrogen, it subjects the asset to high pressure to convert it into steam, subsequently the steam passes through an outlet of the pressurizer (36) which is It is installed in the lower part of the pressurizer (35), to be conducted through a pressurizing line (37) that is connected to the upper part of the cover (17) by means of the instrument connection (19) of this In this way, the vaporized active is introduced into the tank (1).
  • an inert gas preferably nitrogen
  • a control panel (39) is installed in the structure (15), and is arranged for the control and programming of the operation of all the components that make up the machine to mix by means of ultrasound.
  • At least one leveler (40) is installed in the lower part of each leg of the structure (15), said levelers are configured to place the machine to mix by means of ultrasound on uneven floors and maintain its stability.
  • the measuring instruments can be pressure, density, temperature, pH sensors, among others.
  • the pneumatic system (not illustrated) can be air, gas, electric or oil pistons.

Abstract

La présente invention concerne une machine de mélange par ultrasons qui présente l'avantage de comprendre une unité ultrasonore, ce qui permet de convertir une substance liquide en vapeur au moyen des piézoélectriques, et comporte également un agitateur principal et un agitateur secondaire ce qui améliore considérablement le processus de mélange, produisant l'homogénéisation d'un actif et d'un excipient de manière rapide et efficace, ce qui rend plus efficace l'assimilation du produit dans l'organisme qui le consomme. Il est nécessaire de mentionner que l'opération est comparativement mieux effectuée que dans d'autres appareils de mélange étant donné qu'au moyen du tableau de commande, on effectue la programmation du mélange et qu'il n'y a besoin d'aucune opération additionnelle, ce qui réduit les coûts de fonctionnement. Un autre des avantages que présente la machine de mélange par ultrasons, est que, par le jeu de poulies, le contrepoids et la manivelle, il est plus facile de lever le couvercle du réservoir sans qu'il soit nécessaire de démonter les constituants qui sont installés.
PCT/MX2019/000050 2019-02-21 2019-05-03 Machine de mélange par ultrasons WO2020171688A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MXMX/A/2019/002091 2019-02-21
MX2019002091A MX2019002091A (es) 2019-02-21 2019-02-21 Máquina para mezclar por medio de ultrasonido.

Publications (1)

Publication Number Publication Date
WO2020171688A1 true WO2020171688A1 (fr) 2020-08-27

Family

ID=72145010

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2019/000050 WO2020171688A1 (fr) 2019-02-21 2019-05-03 Machine de mélange par ultrasons

Country Status (2)

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MX (1) MX2019002091A (fr)
WO (1) WO2020171688A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0619139A1 (fr) * 1993-04-03 1994-10-12 United Kingdom Atomic Energy Authority Récipient de traitement
EP0619135A1 (fr) * 1993-04-05 1994-10-12 S.I.F.RA. SOCIETA ITALIANA FARMACEUTICI RAVIZZA S.p.A. Système pour la préparation de fluides pour traitement médical
WO2000044468A1 (fr) * 1999-01-29 2000-08-03 Bristol-Myers Squibb Company Appareil et procede de cristallisation par ultrasons par jets contraries
US20020048214A1 (en) * 1999-12-03 2002-04-25 Bih-Tiao Lin Slurry dilution system with an ultrasonic vibrator capable of in-situ adjustment of slurry concentration
WO2012000351A1 (fr) * 2010-06-28 2012-01-05 北京翔奥天竺科技有限公司 Equipement de mélange à ultrasons
MX2012007179A (es) * 2012-06-06 2013-12-13 Andres Abelino Choza Romero Aparato para crosslinking corneal con generador ultrasonico.
CN108905832A (zh) * 2018-07-10 2018-11-30 孔德龙 电池生产的真空搅拌机

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0619139A1 (fr) * 1993-04-03 1994-10-12 United Kingdom Atomic Energy Authority Récipient de traitement
EP0619135A1 (fr) * 1993-04-05 1994-10-12 S.I.F.RA. SOCIETA ITALIANA FARMACEUTICI RAVIZZA S.p.A. Système pour la préparation de fluides pour traitement médical
WO2000044468A1 (fr) * 1999-01-29 2000-08-03 Bristol-Myers Squibb Company Appareil et procede de cristallisation par ultrasons par jets contraries
US20020048214A1 (en) * 1999-12-03 2002-04-25 Bih-Tiao Lin Slurry dilution system with an ultrasonic vibrator capable of in-situ adjustment of slurry concentration
WO2012000351A1 (fr) * 2010-06-28 2012-01-05 北京翔奥天竺科技有限公司 Equipement de mélange à ultrasons
MX2012007179A (es) * 2012-06-06 2013-12-13 Andres Abelino Choza Romero Aparato para crosslinking corneal con generador ultrasonico.
CN108905832A (zh) * 2018-07-10 2018-11-30 孔德龙 电池生产的真空搅拌机

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 985649, Derwent World Patents Index; AN 2018-985649 *

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