WO2020162724A1

WO2020162724A1 - Occlusive thrombus removal device and occlusive thrombus removal method

Info

Publication number: WO2020162724A1
Application number: PCT/KR2020/001798
Authority: WO
Inventors: 민성우
Original assignee: 주식회사 엔벤트릭
Priority date: 2019-02-08
Filing date: 2020-02-07
Publication date: 2020-08-13

Abstract

The present application relates to an occlusive thrombus removal device and an occlusive thrombus removal method, and disclosed is an occlusive thrombus removal device comprising: a self-expanding body including a proximal part having a tube shape formed by a plurality of first struts, and a distal part having a basket shape formed by a plurality of second struts, wherein each second strut extends from the distal end of the proximal part to an attachment end that moves along the longitudinal center axis of the body; and a sleeve which is mounted inside the body, and which defines a surface extending along the plurality of second struts from one circumferential end positioned at the proximal side of the distal end of the proximal part, wherein the sleeve is deformed, according to the proximal movement of the attachment end, from a first state of opening the distal end of the body into a second state of closing the distal end of the body.

Description

Obstruction blood clot removal device and obstruction blood clot removal

The present application relates to an apparatus for removing clots and a method for removing clots. More specifically, embodiments of the present application relate to an apparatus for removing clots and a method for removing clots used to mechanically remove clots from blood vessels.

Vascular disease can be divided into ischemic vascular disease caused by blockage of blood vessels and hemorrhagic vascular disease caused by bursting of blood vessels. Among them, for ischemic vascular disease, blood clots are removed from the blood vessels of the patient for treatment, because blood vessels are obstructed or a strong stricture occurs in the blood vessels, thereby reducing blood flow, thereby necrosis of vascular tissue. In the past, dissolving blood clots by injecting a thrombolytic agent into a vein was a typical treatment method, but recently, a blood clot removal device that mechanically removes blood clots from blood vessels such as a stent retriever has emerged.

The stent retriever is a treatment method that restores blood flow by physically removing blood clots from blood vessels. The user inserts a stent retriever into the patient's blood vessel and expands it, and when the expanded device is integrated with the blood clot, the user can pull the device to remove the blood clot from the blood vessel. However, although the size and hardness of the blood clots located in the patient's blood vessels vary, current stent retrievers cannot capture them in one pass. In addition, since the current stent retriever has limited visibility, the user cannot accurately determine the location or shape of the stent retriever located in the blood vessel under x-ray. In addition, the stent retriever must pass through the serpentine blood vessel due to its anatomical structure. At this time, the stent retriever is excessively deformed, such as stretching, so that the blood clot may escape back into the blood vessel or the blood clot may become fragmented. Finally, due to the above-described problems, the stent retriever may have to repeatedly pass through the blood vessel, which damages the blood vessel wall and increases the procedure time required for reperfusion.

According to an embodiment of the present invention, an apparatus for removing clots or a method for removing clots may be provided that can remove clots in one pass.

According to an embodiment of the present invention, an apparatus for removing clots or a method for removing clots may be provided, which provides improved visibility to a user.

According to an embodiment of the present invention, an apparatus for removing clots or a method for removing clots may be provided that is not excessively deformed according to the diameter or structure of a blood vessel.

According to an aspect of the present invention, a self-expandable body including a proximal portion having a tubular shape formed through a plurality of first struts and a distal portion having a basket shape formed through a plurality of second struts-each of the second struts comprises the It extends from the distal end of the proximal portion to the attachment end configured to move along the longitudinal central axis of the self-expandable body-, and a circumference mounted inside the self-expandable body and located proximal to the distal end of the proximal portion In the obstruction thrombus removal apparatus comprising a sleeve defining a surface extending from a distal end along the plurality of second struts, wherein the sleeve moves the other circumferential end of the surface of the sleeve toward the central axis in the longitudinal direction. In accordance with the proximal movement of the attachment end, from a first state in which the distal end of the self-expandable body is opened, a device for removing obstruction thrombi is transformed into a second state in which the distal end of the self-expandable body is closed.

According to another aspect of the invention, a self-expandable body having a plurality of struts, a proximal opening attached to a distal portion of the self-expandable body, and a seal providing a tube surface having a distal opening, the distal opening and A pull wire configured to be connected to operate and slidable along a longitudinal direction of the self-expandable body, and when the pull wire is positioned in the first position, the thread has a distal diameter similar to the proximal opening Through the opening, the blood clot can enter the self-expandable body, and when the pull wire is located in a second position different from the first position, the thread closes the distal opening so that the blood clot is released from the self-expandable body. It provides an obstructive blood clot removal device that prevents it from exiting.

According to another aspect of the present invention, a pull wire provided to be slidably movable in a blood vessel according to a longitudinal direction and a protruding member is formed at one point, and the pull wire moves relatively along the length direction with respect to the pull wire It is possible to be disposed on the pull wire, the tubular member positioned proximal to the protruding member, a body including a plurality of struts having one end connected to the tubular member, and provided on the distal end of the body, the pull wire The step of operatively coupled to (operatively coupled) the step of positioning the clot blockage removal device including a sleeve that opens and closes the distal end of the body in accordance with the sliding movement of the wire inside the blood vessel in a state inserted into the catheter, from the catheter The obstruction thrombus removal device is deployed as the obstruction thrombus removal device is released.- In the deployed obstruction thrombus removal device, the protruding member is spaced apart from the tubular member, and the distal end of the body is the Deployed in an open state by a sleeve-, as the pull wire moves proximally to a point where the protruding member and the tubular member meet, the clogging blood clot removal device is deformed in a state in which the distal end of the body is closed by the sleeve. -While the pull wire moves proximally to the point where the protruding member and the tubular member meet, the obstruction thrombus removing device does not substantially move -, the pull wire is from the point where the protruding member and the tubular member meet. Moving the obstruction thrombus removing device proximally while the fabric of the body is closed by the sleeve as it moves proximally-The length direction of the body as the pull wire defines the lengths of both ends of the body It provides a method for removing obstructive blood clots, including-preventing stretching according to.

The solution means of the subject of the present invention is not limited to the above-described solution means, and solutions that are not mentioned will be clearly understood by those of ordinary skill in the art from the present specification and the accompanying drawings. I will be able to.

According to an embodiment of the present invention, the obstruction thrombus removal apparatus or the obstruction thrombus removal method closes the distal end of the stent body through the movement of a wire, thereby removing blood clots in different states in one pass.

According to an exemplary embodiment of the present invention, an apparatus for removing a clot or a method for removing a clot may provide improved visibility to a user by including a material having high visibility.

According to an embodiment of the present invention, the obstruction thrombus removal device or the obstruction thrombus removal method may prevent excessive deformation of the stent body by transmitting force to at least two positions of the stent body connected to the wire.

1 is a diagram showing an apparatus for removing a clot according to a first embodiment of the present invention.

2 is a diagram showing an apparatus for removing clots in a first state according to the first embodiment of the present invention.

3 is a diagram showing an apparatus for removing clots in a second state according to the first embodiment of the present invention.

4 is a view showing a tubular body of an apparatus for removing clots according to a first embodiment of the present invention.

5 is a view showing a modified example of the obstruction thrombus removal apparatus according to the first embodiment of the present invention.

6 is a view showing an internal stent body of a modified example of the obstruction thrombus removal apparatus according to the first embodiment of the present invention.

7 and 8 are views showing the operation of the obstruction thrombus removal apparatus according to the first embodiment of the present invention.

9 is a diagram illustrating a procedure of a method for removing a clot according to the first embodiment of the present invention.

10 is a diagram illustrating a procedure of a method of removing a clot according to the first embodiment of the present invention.

11 and 12 are diagrams illustrating an apparatus for removing clots in a first state according to a second exemplary embodiment of the present invention.

13 and 14 are diagrams illustrating an apparatus for removing clots in a second state according to a second exemplary embodiment of the present invention.

15 is a diagram showing a marker of an apparatus for removing clots according to a second embodiment of the present invention.

16 is a diagram showing an apparatus for removing clots according to a third embodiment of the present invention.

Mechanical thrombus removal devices currently used in the treatment of vascular diseases require improved features in integration with thrombi, capturing fragmented thrombi, user visibility, and traversing the serpentine vascular structure.

It is preferable that the mechanical blood clot removal device can remove blood clots of different sizes or hardness in one pass. It is preferable that the mechanical thrombus removal device has a design capable of clot integration with thrombus in different states in order to minimize the procedure time. In order to prevent further damage that may occur to the patient due to the mechanical thrombus removal device, it is preferred that the mechanical thrombus removal device is capable of trapping fragmented thrombus. In addition, it may be important to minimize the time required for reperfusion by improving the visibility of the mechanical thrombus removal device to provide convenience to the user. Finally, since the serpentine vessel structure makes it difficult for the mechanical thrombus removal device to recover the clot, the stent retriever is preferably designed to pass through the serpentine vessel after capturing the clot.

Hereinafter, an apparatus for removing clots according to an embodiment of the present specification will be described. The obstruction thrombus removal device is a mechanical thrombus removal device used in the treatment of vascular diseases, and can restore blood flow by capturing a thrombus located in a blood vessel and recovering it outside the body.

The obstruction thrombus removal apparatus according to an embodiment of the present specification may have features such as fragmented thrombus capture, axial structure preservation, overall axial flexibility or improved visibility compared to known mechanical thrombus removal apparatuses.

Thrombus fragment capture can be achieved by deforming the distal portion of the stent body through proximal movement of the wire. A sleeve may be disposed at the distal portion of the stent body, and the distal portion of the stent body may be connected to a wire. In a state in which the obstruction thrombus removal device is deployed, the distal end of the stent body may provide a passage for a substance.

The distal portion of the stent body can be designed to be bent. When the wire moves in the proximal direction, the distal end of the stent body can be closed by a closed seal. When the wire moves in the proximal direction, the distal part of the stent body connected to the wire may be moved toward the inside of the stent body, and the distal part of the stent body may be folded. The ring or tubular member may limit the relative movement of the wire with respect to the stent body. The distal portion of the stent body folded toward the inside of the stent body may form a closed seal. Closed seals can trap fragmented clots during the clot recovery process.

If the wire moves and the entire stent body is compressed in the axial direction, the clot can be better integrated into the stent body. This axial compression of the stent body allows the stent body to better integrate blood clots.

Axially structural integrity can prevent the obstructive thrombus removal device from excessive deformation. In addition, it allows the obstruction thrombus removal device to pass well even in the serpentine anatomy. If the obstruction thrombus removal device is deformed in the process of recovering the thrombus, the thrombus may leak from the stent body. Deformation of the stent body can be controlled by the wire pulling the stent body in at least two or more areas-the proximal and distal parts of the stent body. The wire and the stent body may be connected in more areas. Rather than pulling the stent body by transmitting the force through only the proximal portion of the stent body, the wire transmitting force to the stent body through a plurality of areas can prevent the stent body from being excessively deformed.

Overall axial flexibility can be realized through a flexible and divided structure. The flexible and segmented structure can prevent the stent body from missing captured blood clots. In addition, the flexible and segmented structure allows the obstruction thrombus removal device to pass even in the serpentine anatomical vascular structure. The stent body may have a divided shape. Unlike the homogeneous composition of the substance (material), the divided shape can control the radial shape in the serpentine anatomical structure by partially containing less material. As the shape of the stent body increases in the radial direction, the deformation in the longitudinal direction of the stent body is limited, and the stent body can better hold the captured coagulation.

The improved visibility can provide convenience in use to the user. By coating or depositing a highly visible material, the user can see the shape or location of the obstruction thrombus removal device. Improved visibility may be provided in the form of a marker or wire. During the procedure, the user can check the extent to which the obstruction thrombus removal device is expanded and whether the obstruction thrombus removal device is located near the target thrombus. The user can increase the success rate of capturing blood clots in one pass by checking the shape and location of the obstruction blood clot removal device.

According to an aspect of the present invention, a self-expandable body including a proximal portion having a tubular shape formed through a plurality of first struts and a distal portion having a basket shape formed through a plurality of second struts-each of the second struts comprises the It extends from the distal end of the proximal part to the attachment end configured to move along the longitudinal central axis of the self-expandable body-and one circumferential end mounted inside the self-expandable body and located proximal to the distal end of the proximal part In the obstruction thrombus removal device comprising a sleeve defining a surface extending along the plurality of second struts from, the sleeve, wherein the sleeve moves the other circumferential end of the surface of the sleeve toward a central axis in the longitudinal direction. According to the proximal movement of the attachment end, the first state of opening the distal end of the self-expandable body may change to a second state of closing the distal end of the self-expandable body. The sleeve in the first state has a first diameter at the other circumferential end, the sleeve in the second state has a second diameter at the other circumferential end, and the first diameter may be larger than the second diameter. have. In the first state, the attachment end is located distal to the one circumferential end, the attachment end is located inside the self-expandable body, and in the second state, the attachment end is proximal to the one circumferential end. Located proximal to the other circumferential end, the attachment end and the other circumferential end may be located inside the self-expandable body. In addition, a pull wire connected to the self-expandable body through the attachment end and moving along a central axis in a longitudinal direction of the self-expandable body, wherein the sleeve is formed by the proximal movement of the pull wire. The first state can be changed to the second state. In addition, at least one stopper mounted on the pull wire and restricting movement of the pull wire, further comprising, when the sleeve changes from the first state to the second state, at least one stopper and the The distance between the proximal ends of the self-expandable body can be reduced. In the second state, the at least one stopper may transmit a force for moving the self-expandable body according to the proximal movement of the pull wire. In the second state, the pull wire transmits a force to the distal portion through the attachment end of the self-expandable body, and the pull wire applies a force to the proximal portion of the self-expandable body through at least one stopper. Can deliver. The stopper may include a first stopper located distal to the proximal end of the self-expandable body and a second stopper located proximal to the proximal end of the self-expandable body. In addition, further comprising a tubular member slidably mounted on the pull wire and connected to the proximal end of the self-expandable body, and in the second state, at least one stopper is in contact with the tubular member, and the pull According to the proximal movement of the wire, the self-expandable body may move proximally. A gap may be formed between at least two struts disconnected from each other among the first struts of the self-expandable body.

According to another aspect of the present invention, the obturator thrombus removal device includes a self-expandable body having a plurality of struts, a proximal opening attached to the distal portion of the self-expandable body, and a seal providing a tube surface having a distal opening. And a pull wire operatively coupled with the distal opening and configured to be slidable along a longitudinal direction of the self-expandable body, wherein when the pull wire is positioned in the first position, the thread is Through a distal opening having a diameter similar to that of the proximal opening, the thrombus can enter the self-expandable body, and when the pull wire is located in a second position different from the first position, the thread closes the distal opening It is possible to prevent blood clots from escaping from the self-expandable body. When the pull wire is positioned in the second position, the yarn can be partially folded toward the pull wire. While the pull wire is positioned from the first position to the second position, the proximal portion of the self-expandable body may not substantially move. When the pull wire moves from the second position to a third position located on the opposite side of the first position, the self-expandable body may move integrally with the pull wire. While the pull wire moves from the second position to the third position, the thread may maintain a folded shape. The first position, the second position, and the third position may, in order, be directed from distal to proximal of the self-expandable body. In addition, it is mounted on the pull wire, further comprising at least one stopper limiting the movement of the pull wire, when the pull wire is moved from the first position to the second position, at least one stopper and The distance between the proximal ends of the self-expandable body can be reduced. While the pull wire moves from the second position to a third position located on the opposite side of the first position, the positional relationship between both ends of the pull wire and both ends of the self-expandable body by at least one stopper As it is fixed, the pull wire may maintain a constant length of the self-expandable body. A gap may be formed between at least two struts disconnected from each other among the struts of the self-expandable body.

According to another aspect of the present invention, a method of removing a clot in a blood vessel is provided to be slidably movable in a blood vessel in a longitudinal direction, and a pull wire having a protruding member formed at one point, the lengthwise direction with respect to the pull wire. A tubular member disposed on the pull wire so as to be relatively movable according to the protruding member, a body including a plurality of struts having one end connected to the tubular member, and a distal end of the body It is operatively coupled to the pull wire (operatively coupled) to position the inside of the blood vessel in the state of being inserted into the catheter in the state of being inserted into the catheter, the obstruction thrombus removal device including a sleeve that opens and closes the fabric of the body according to the sliding movement of the wire. Step, wherein the obstruction thrombus removal device is deployed as the obstruction thrombus removal device is released from the catheter.- In the deployed obstruction thrombus removal device, the protruding member is spaced apart from the tubular member, and the The distal end of the body is deployed in an open state by the sleeve-As the pull wire moves proximally to the point where the protruding member and the tubular member meet, the distal end of the body is closed by the sleeve to remove the obstruction thrombus. The step of deforming the device-while the pull wire moves proximally to the point where the protruding member and the tubular member meet, the obstruction thrombus removing device does not substantially move -, the pull wire is moved to the protruding member and the tubular member Moving the obstruction thrombus removing device proximally with the distal end of the body closed by the sleeve as the member moves proximally from the point where the member meets-As the pull wire defines the lengths of both ends of the body, the It includes;-preventing the body from stretching along the length direction.

Hereinafter, specific embodiments will be described in detail with reference to the drawings. However, the spirit of the invention is not limited to the presented embodiments, and those skilled in the art who understand the spirit of the invention can add, change, or delete other elements within the scope of the same idea. Other embodiments included within the scope may be easily proposed, but this will also be said to be included within the scope of the inventive concept.

Throughout this specification, the use of a relative word may indicate a relative position or direction. For example,'proximal' may refer to a first direction along the longitudinal direction of the device. Similarly,'distal' may refer to a second direction opposite to the aforementioned first direction. These terms are provided to set a relative criterion, and are not intended to limit the use, position, or direction of the occlusive thrombus removal device to the specific configuration described in the various embodiments below.

Hereinafter, an apparatus for removing clots according to a first embodiment will be described.

The obstruction thrombus removal apparatus 1000 according to the first exemplary embodiment may engage with the thrombus and capture the fragmented thrombus. The obstruction thrombus removal apparatus 1000 according to the first embodiment may prevent excessive deformation of the stent body 100. The obstruction thrombus removal apparatus 1000 according to the first embodiment may have a variable diameter. The obstruction thrombus removal apparatus 1000 according to the first exemplary embodiment may provide improved visibility to a user.

In detail, the obstruction thrombus removal apparatus 1000 according to the first embodiment may form a closed seal by deforming the stent body 100 through movement of the wire 200. The obstruction thrombus removal apparatus 1000 according to the first exemplary embodiment may prevent separation of the thrombus by limiting the deformation of the stent body 100. Through this, the obstruction thrombus removal apparatus according to the first embodiment may remove the thrombus from the blood vessel in one pass.

The obstruction thrombus removal apparatus 1000 according to the first embodiment may connect the wire 200 and the stent body 100 at at least two positions. The obstruction thrombus removal apparatus 1000 may connect the wire 200 and the stent body 100 at each of the proximal and distal portions. Through this, the obstruction thrombus removal apparatus 1000 may prevent the stent body 100 from being deformed by a certain amount or more.

The obstruction thrombus removal apparatus 1000 according to the first embodiment may have a partially divided form. The divided form may provide flexibility in the radial direction to the stent body 100 of the obstruction thrombus removal apparatus 1000. Through this, the obstruction thrombus removal apparatus 1000 may change in diameter according to the size or shape of a blood vessel. The obstruction thrombus removal apparatus 1000 may prevent deformation in the longitudinal direction as it expands in the radial direction.

The obstruction thrombus removal apparatus 1000 according to the first embodiment may include a material visible to a user at a short wavelength such as x-rays. For example, the obstruction thrombus removal apparatus 1000 may include a marker located on a strut. For another example, the apparatus 1000 for removing clots according to the first embodiment may improve visibility through coating. For another example, the apparatus 1000 for removing clots according to the first embodiment may improve visibility through deposition. For another example, the apparatus 1000 for removing clots according to the first embodiment may improve visibility through a wire including an impermeable material. The above-described marker, coating, or deposition may include a material visible to a user at a short wavelength such as x-ray.

Hereinafter, components of the apparatus for removing clots according to the first embodiment will be described in detail.

FIG. 1 is a view showing an apparatus for removing clots according to a first embodiment of the present invention, and FIG. 2 is a view showing an apparatus for removing clots in a first state according to a first embodiment of the present invention, and FIG. 3 Is a diagram showing an apparatus for removing clots in a second state according to the first embodiment of the present invention.

The obstruction thrombus removal apparatus 1000 according to the first exemplary embodiment may be transformed between two states of a first state and a second state. Here, the first state may be a state in which a blood clot located inside the stent body 100 can pass through the distal end of the stent body 100. The first state is shown in FIG. 2. The second state may be a state in which a blood clot located inside the stent body 100 cannot pass through the distal end of the stent body 100. The second state is shown in FIG. 3.

1 to 3, the obstruction thrombus removal apparatus 1000 of the first embodiment may include a stent body 100, a wire 200, a ring 300, a tubular member 400, and a sleeve 500. I can.

The stent body 100 may engage with blood clots. The wire 200 may deform the stent body 100 through movement within a specific section. The wire 200 may move through a specific section to move the stent body 100. The ring 300 may limit the movement of the wire 200 related to the stent body 100. Ring 300 may be a stopper. The tubular member 400 may limit movement of the wire 200 associated with the stent body 100 through interference with the ring 300. Here, the tubular member 400 may be connected to the strut 101 at the proximal end of the stent body 100. The sleeve 500 may be attached to the stent body 100 to close the distal end of the stent body 100 according to the movement of the wire 200.

The stent body 100 may engage with blood clots. Here, the engaging may mean that all or at least part of the blood clot is attracted to the inside of the stent body 100. Engaging may mean that the stent body 100 and the blood clot engage with the stent body 100 during the process of expanding the stent body 100. Engaging may mean that a blood clot penetrates the stent body 100 while the stent body 100 is inflated. Engaging means that the blood clot is fixed to the stent body 100. As another example, a blood clot may be held by the stent body 100.

In addition, the engaging may mean that the blood clot is collected by entering the inside of the stent body 100. The target blood clot may enter the inside of the stent body 100 along the blood flow. Engaging may mean capturing a target blood clot that has entered the stent body 100. Engaging may mean receiving a target blood clot in the inner space of the stent body 100. Engaging should not be interpreted as being limited to the above-described example, and should be interpreted by encompassing various examples explaining the integration between the stent body 100 and the thrombus.

The stent body 100 may include a strut 101. The strut 101 may be one. There may be two or more struts 101. Strut 101 may be a line or a post. The strut 101 may form the stent body 100 by forming an intersection. Strut 101 may form a tube shape. Strut 101 may form a basket shape. A space may be formed between the struts 101. The thrombus engaged with the stent body 100 may engage the strut 101. The thrombus engaged with the stent body 100 may be fixed between the struts 101. The strut 101 of the stent body 100 may contact the blood clot. The stent body 100 may capture a blood clot that has entered through the strut 101 of the stent body 100.

The strut 101 may extend along the longitudinal direction of the stent body 100, and may extend helically around an axis in the longitudinal direction of the stent body 100. The strut 101 may extend along the circumference of the stent body 100.

Strut 101 may form a cell 103. Cell 103 may be formed by struts 101 forming intersections. The cells 103 may be located adjacent to each other along the length direction of the stent body 100. The cell 103 may be located along the circumference of the stent body 100 toward an axis in the direction of the road. The thrombus may be engaged with the stent body 100 through the cell 103. While the stent body 100 expands, a part of the blood clot may penetrate into the stent body 100 through the cell 103. The thrombus may be fixed to the cell 103. The blood clot can be held in the cell 103. The blood clot may be trapped inside the stent body 100 through the cell 103. The stent body 100 may capture internal blood clots.

The stent body 100 may be deformed between a contracted state and an expanded state. The stent body 100 may expand from a contracted state and deformed into an expanded state. The stent body 100 may be inserted into a blood vessel in a constricted form to expand within the blood vessel. The stent body 100 of the apparatus 1000 for removing obstructed blood vessels inserted into the blood vessel may be in a contracted state by a tubular member such as a catheter. When the catheter is recovered in the proximal direction, the stent body 100 may be expanded by reducing radial external force by the catheter. The deployed state of the stent body 100 may be a state in which the stent body 100 is expanded. The stent body 100 may expand itself.

The stent body 100 may be an elastic body. The stent body 100, which is an elastic body, can expand itself. The elastic stent body 100 may be deformed from a contracted state to an expanded state by expanding. The strut 101 of the stent body 100 may be an elastic body. The strut 101 of the stent body 100 may be an elastic body including a shape memory alloy. Strut 101 of the stent body 100 may include a nickel titanium alloy (nickel titanium alloy) or a material restored to a shape stored at high temperature when heated. The stent body 100 may be manufactured through a manufacturing method such as laser cutting, micro machining, electrical discharge machining (EDM), or braiding.

The stent body 100 may be formed by cutting a metal tube. The stent body 100 may be a framework formed through a metal wire. The stent body 100 may be formed by connecting metal wires. Metal wires include mechanical locks, welding, soldering (soldering), brazing (brazing), adhesive molding, crimping, and swaging. ) Or may be connected through epoxy, but is not limited thereto. Mechanical locks may include, but are not limited to, twisting, knitting, webbing, meshing, or intertwining. In this case, the metal wire may be the strut 101. In this case, the metal wire may be the aforementioned elastic body. The metal wire may include a material that provides visibility to a user. The metal wire may comprise platinum, a platinum iridium alloy, or other material with high visibility under x-ray. A material that provides visibility may be located in the core of the metal wire. A material that provides visibility may be located in the shell of the metal wire. A material that provides visibility can be located on the side of the metal wire.

The stent body 100 may be connected to other components of the obstruction thrombus removal apparatus 1000 through mechanical locks, welding, soldering (soldering) or brazing (brazing). .

The expanded stent body 100 may have a hollow hollow shape. A blood clot may be located in an empty space of the expanded stent body 100. The expanded stent body 100 may have a tube shape or a tube shape. Here, the tube shape may mean a cylindrical shape, a large long shape, a cylindrical shape, or a tubular shape. The diameter of the tubular or cylindrical shape can be similar from one end to the other. The expanded stent body 100 may have a basket shape or a basket shape. Here, the basket shape may mean a conical shape, a domical shape, a cone shape, or a dome shape. The diameter of the basket shape can be narrowed from one end to the other.

Both ends of the stent body 100 may have a basket shape. The central portion of the stent body 100 may have a tube shape. The proximal ends of the stent body 100 may be gathered at one point. The distal ends of the stent body 100 may be gathered at one point. The proximal end of the stent body 100 may be connected to the tubular member 400. The distal end of the stent body 100 may be gathered at the attachment point 130. The strut 101 of the stent body 100 may extend from the attachment point 130 to the tubular member 400. The attachment point 130 may be an attachment end of the strut 101. The attachment point 130 may be an attachment end.

Here, the proximal end may mean a point located at the most proximal position in the stent configuration. The proximal end can be the proximal end or the proximal end. The distal end may mean a point located at the most distal end in the corresponding configuration. The distal end may be a distal or distal end. Components of the stent body 100 as well as the obstruction vessel removal apparatus 1000 may each have a distal end or a proximal end.

The connection point 140 may be a position where the diameter of the stent body 100 changes. The connection point 140 may be positioned between the tube shape and the basket shape of the stent body 100. The strut 101 may extend from the proximal end of the stent body 100 to a connection point 140 located around an axis in the longitudinal direction to form a basket shape. The strut 101 may extend from the distal end of the stent body 100 to the connection point 140 located around the longitudinal axis to form a basket shape. The connection point 140 may be one, and may be two or more. The connection point 140 may be symmetrically positioned around the longitudinal axis of the stent body 100. The connection point 140 may be located along the circumference of the stent body 100.

The stent body 100 may include a proximal body 110 and a distal body 120. The proximal body 110 may be a proximal portion of the stent body 100. The distal body 120 may be a distal portion of the stent body 100. The proximal body 110 may be positioned proximal to the distal body 120. The proximal end of the stent body 100 may be located on the proximal body 110. The distal end of the stent body 100 may be located on the distal body 120.

The proximal portion of the proximal body 110 may have a basket shape. The distal portion of the proximal body 110 may have a tubular shape. The diameter of the proximal body 110 may become narrower toward the proximal end. The distal body 120 may have a basket shape. The diameter of the distal body 120 may be narrower toward the distal end. The diameter of the proximal end of the distal body 120 may be similar to the diameter of the distal end of the proximal body 110.

The struts 101 at the proximal end of the proximal body 110 may be gathered at one point. The proximal end of the proximal body 110 may be located close to the central axis of the stent body 100. According to some embodiments, the proximal end of the proximal body 110 may be located close to a point on the side of the stent body 100.

The proximal end of the proximal body 110 may be connected to the wire 200. The proximal end of the proximal body 110 may be connected to the wire 200 through the tubular member 400. The proximal body 110 may not be fixed to the wire 200. As the wire 200 moves, the relative positional relationship between the proximal body 110 and the wire 200 may change.

The strut 101 at the distal end of the distal body 120 may be gathered at the attachment point 130. The distal end of the distal body 120 may be connected to the wire 200. The distal end of the distal body 120 may be connected to the wire 200 at the attachment point 130. Each strut 101 of the distal portion of the distal body 120 is connected to the wire 200 through the attachment point 130, so that the distal body 120 may be deformed according to the movement of the wire 200. The distal body 120 may be dependent on the movement of the wire 200. The distal end of the distal body 120 may be located close to the central axis of the stent body 100 according to the position of the wire 200. Depending on the location of the wire 200 according to some embodiments, the attachment point 130 may be located outside the stent body 100 or may be located on the side of the stent body 100.

The wire 200 may be positioned along the length direction of the stent body 100 to support the stent body 100. The wire 200 may be in the form of a line extending from the proximal end of the stent body 100 to the distal end of the stent body 100.

The wire 200 may slide along the length direction of the stent body 100. The wire 200 may be for transmitting a pulling force to the obstruction thrombus removal device 1000. The wire 200 may be for transmitting a pushing force to the obstruction thrombus removal device 1000. The wire 200 may be a full wire.

The wire 200 may be located inside the stent body 100. The wire 200 may be positioned along the central axis of the stent body 100, or may be positioned lean to one side. According to some embodiments, the wire 200 may be located outside the stent body 100.

The wire 200 may deform the stent body 100 through movement. The wire 200 may deform the stent body 100 by moving from the first position in the first state to the second position in the second state. The wire 200 may be connected to the stent body 100 and the attachment point 130. The distal body 120 may be affected by the movement of the wire 200. When the wire 200 moves from the first position to the second position, the attachment point 130 moves along the wire, and the stent body 100 may be transformed into a first state or a second state. The distal body 120 of the stent body 100 may be shortened by being deformed into a first state or a second state. The length of the stent body 100 deformed from the first state to the second state may be shortened.

When the wire 200 further moves from the first position to the second position, the length of the stent body 100 may be shorter. When the wire is further moved from the second position to the first position, the length of the stent body 100 may be longer.

The wire 200 and the stent body 100 may be temporarily fixed through a stopper. The stopper may temporarily fix the wire 200 and the stent body 100 outside a specific section. Through this, the user may transmit a force to move the stent body 100. Deformation of the stent body 100 by the wire 200 by the stopper may be limited. Stretching in the longitudinal direction of the stent body 100 by the wire 200 by the stopper may be limited. The wire 200 may move together with the stent body 100 by the stopper. The wire 200 may move the stent body 100 to be close to the target blood clot. The wire 200 may recover the expanded stent body 100 in which the blood clot is captured from the blood vessel. The stopper may be a ring 300

The wire 200 may prevent the stent body 100 from being excessively deformed when the stent body 100 moves. In general, when the wire 200 is pulled proximally in the process of recovering the obstruction thrombus removal device 1000, the proximal portion of the stent body 100 may receive more force than the distal portion. At this time, the stent body 100 may be deformed in the longitudinal direction and in the radial direction. In detail, the length of the stent body 100 may be increased and the diameter may be narrowed. However, since the wire 200 of the first embodiment is connected to the stent body 100 at two points, deformation of the stent body 100 may be prevented. The distal portion of the stent body 100 is connected to the wire 200 at the attachment point 130, so that force may be transmitted to the distal portion of the stent body 100. The proximal portion of the stent body 100 may be temporarily fixed to the wire 200 through a stopper. Through this, deformation of the stent body 100 in the longitudinal direction may be limited. The deformation in the radial direction of the stent body may be limited. The stent body 100 may prevent separation of blood clots according to a change in shape. Details will be described later.

The wire 200 may include a material of high tensile strength. The wire 200 may include a nickel titanium alloy or stainless steel. The wire 200 may be connected to the stent body 100 through mechanical locks, welding, soldering (soldering), or brazing (brazing). In detail, the wire 200 may be connected to the attachment point 130 of the stent body 100 through the above manufacturing method.

The wire 200 may be provided with a stopper limiting the relative distance to the stent body 100. The stopper may be a protruding member. The stopper may be a ring 300. The ring 300 is provided in a form protruding from the surface of the wire 200, thereby limiting the relative distance between the wire 200 and the stent body 100. The ring 300 may be fixed to a specific position of the wire 200.

The ring 300 may be formed in various ways and positioned on the wire 200. The ring 300 may be formed integrally with the wire 200. The ring 300 may be a bump of the wire 200 and may be in the form of, for example, spot welding or a coined section, but is not limited thereto. The ring 300 may be a separate component distinguished from the wire 200. The ring 300 may be in the form of a tube having an inner diameter and an outer diameter. The inner diameter of the ring 300 may be similar to the diameter of the wire 200. The ring 300 may be crimped or bonded to the outer surface of the wire, but is not limited thereto.

The tubular member 400 may be provided in a tube shape. The tubular member 400 may be slidably mounted on the wire 200. The wire 200 may slide the inside of the tubular member 400. Depending on the inner shape of the tubular member 400, the rotation of the wire 200 may be limited. For example, a groove may be formed in an intaglio inside the tubular member 400, and a projection corresponding thereto may be formed on the outer surface of the wire 200. As the groove of the tubular member 400 and the protrusion of the wire 200 correspond to each other, the rotation of the wire 200 may be limited.

The tubular member 400 may be connected to the proximal end of the stent body 100. The proximal body 110 of the stent body 100 is connected to the wire 200 through the tubular member 400, so that it can slide on the wire 200 without being fixed to the wire 200. Through this, the proximal body 110 of the stent body 100 may be less affected by the movement of the wire 200 than the distal body 120. When the distal body 120 is deformed according to the movement of the wire 200, the proximal body 110 may not be substantially deformed. When the distal body 120 is deformed according to the movement of the wire 200, the proximal body 110 may not be substantially moved. The tubular member 400 may be a part of the proximal end of the stent body 100.

The ring 300 and the tubular member 400 may be positioned in a straight line to limit the movement of the wire 200 with respect to the stent body 100. The wire 200 may deform the stent body 100 when the ring 300 and the tubular member 400 are not in contact. The wire 200 is fixed to the proximal end of the stent body 100 when the ring 300 and the tubular member 400 contact, and may move the stent body 100.

The ring 300 and the tubular member 400 may fix the stent body 100 and the wire 200 at the first position or the second position. Between the first position and the second position of the wire 200 may be a deformation section. The deformation section is between the proximal terminal of the stent body 100 and the wire 200 It may be a section in which the distance between specific locations varies. The specific position of the wire 200 may be the position of the ring 300. The deformation section may be a section in which the distance between the tubular member 400 and the ring 300 changes according to the movement of the wire 200.

The ring 300 may be positioned at a distance from the tubular member 400. The distance between the ring 300 and the tubular member 400 may correspond to the distance between the deformation section of the wire 200.

The wire 200 moving in the first direction may transform the stent body 100 from the first position to the second position from the first position to the second state. In this case, the ring 300 may be located at the proximal end of the stent body 100 or in the second direction of the tubular member 400. The second direction may be a direction opposite to the first direction. When moving to the wire 200 in the first direction, the proximal end of the stent body 100 or the distance between the tubular member 400 and the ring 300 may be reduced. The distance between the proximal end of the stent body 100 or between the tubular member 400 and the ring 300 may be reduced, and thus close to zero. When the wire 200 passes through the second position and further moves in the first direction, it may be fixed to the stent body 100 by the ring 300 and the tubular member 400. At this time, the stent body 100 may move along the wire 200 without any further deformation.

The wire 200 moving in the second direction may transform the stent body 100 from the second position to the first position from the second state to the first state. In this case, the ring 300 may be located at the proximal end of the stent body 100 or in the first direction of the tubular member 400. When moving to the wire 200 in the first direction, the proximal end of the stent body 100 or the distance between the tubular member 400 and the ring 300 may be reduced. The distance between the proximal end of the stent body 100 or between the tubular member 400 and the ring 300 may be reduced, and thus close to zero. When the wire 200 passes through the first position and moves in the second direction, it may be fixed to the stent body 100 by the ring 300 and the tubular member 400. At this time, the stent body 100 may move along the wire 200 without any further deformation.

The ring 300 may limit the movement of the wire 200 relative to the stent body 100 in a specific direction according to a position relative to the tubular member 400. When the ring 300 is located in the first direction of the tubular member 400, the ring 300 may limit the movement of the wire 200 in the second direction. The first direction and the second direction may be opposite to each other.

When the ring 300 located proximal to the tubular member 400 and the tubular member 400 contact, the movement of the wire 200 relative to the proximal end of the stent body 100 or the tubular member 400 in the distal direction Can be limited.

When the ring 300 located distal to the tubular member 400 and the tubular member 400 contact, the proximal end of the stent body 100 or the movement of the wire 200 relative to the tubular member 400 in the proximal direction Can be limited.

The ring 300 and the tubular member 400 may prevent the obstruction thrombus removal apparatus 1000 from being excessively deformed. Since the movement of the wire 200 is limited by the ring 300 and the tubular member 400, the deformation of the stent body 100 and the sleeve 500 may be limited within the range of the first state and the second state. Deformation of the obstruction thrombus removal apparatus 1000 may be limited between the first state and the second state.

In the process of recovering the stent body 100 outside the blood vessel, the stent body 100 may be deformed by blood flow or the structure of the blood vessel. When the movement of the wire 200 relative to the stent body 100 is restricted through the ring 300 and the tubular member 400, the proximal end of the stent body 100 may be temporarily fixed to the wire 200. In this case, the force transmitted to the stent body 100 through the ring 300 may be transmitted to the proximal body 110 of the stent body 100. The wire 200 transmits force to the distal body 120 through the attachment point 130, and the ring 300 transmits the force to the proximal body 110, so that the wire 200 and the ring 300 are stents. It is possible to prevent the body 100 from being excessively deformed by the blood vessel structure.

There may be one ring 300. One ring 300 may limit movement of the wire 200 in relation to the stent body 100 in a single direction according to a relative positional relationship with the proximal end of the stent body 100.

There may be two or more rings 300. The ring 300 may include a first ring 310 and a second ring 320. The first ring 310 is located at the proximal end of the stent body 100 or the proximal end of the tubular member 400, and the second ring 320 is at the proximal end of the stent body 100 or the distal end of the tubular member 400 Can be located. The first ring 310 and the second ring 320 may be positioned at a distance. The distance between the first ring 310 and the second ring 320 may correspond to a distance between the deformation section of the wire 200.

The tubular member 400 may be provided in a long tube shape. When the tubular member 400 has a long tube shape, the user can manipulate the tubular member 400 outside the blood vessel. The user can easily fix or move the entire stent body 100 through the tubular member 400 in the form of a long tube. When the user fixes the tubular member 400, the proximal end of the stent body 100 may be temporarily fixed. When the user moves the tubular member 400, force is transmitted through the proximal end of the stent body 100 so that the entire stent body 100 may be moved.

When the tubular member 400 has a long tube shape, the ring 300 may be located distal to the tubular member 400. The user can manipulate the tubular member 400 or wire 200 from outside the blood vessel, and the user can manipulate the tubular member 400 or wire 200 to adjust the distance between the tubular member 400 and the ring 300 Can be adjusted. Through this, the movement of the wire 200 relative to the stent body 100 may be restricted. Details are as described above.

The ring 300 and the tubular member 400 may include a nickel titanium alloy, platinum, a platinum iridium alloy, or a stainless-steel alloy. The ring 300 and the tubular member 400 may be connected to the wire 200 through mechanical locks, welding, soldering (soldering) or brazing (brazing).

The obstruction thrombus removal apparatus 1000 through the sleeve 500 may prevent the outflow of the thrombus. Sleeve 500 may function as a filter or capture device. The sleeve 500 may be a seal. A seal can close a space or area. The blood clot may be fragmented while the stent body 100 expands and is engaged with the blood clot. The size of the fragmented thrombus may be smaller than the size of the cell 103 of the stent body 100. The sleeve 500 may be deformed in the form of a closed seal that closes the distal end. Closed seals can trap fragmented clots. The sleeve 500 may prevent leakage of fragmented blood clots.

The characteristic according to the deformation of the sleeve 500 may be referred to as an active seal. The sleeve 500 may be deformed between an open seal form and a closed seal form. The dynamic structure of the active seal can be achieved by fixing the wire 200 only at one end of the strut 101-the attachment point 103-at the distal end of the stent body 100. The dynamic structure of the active seal may be implemented by restricting the movement of the wire 200 relative to the stent body 100 through contact between the ring 300 and the tubular member 400.

The sleeve 500 may be deformed between a first state and a second state according to the movement of the wire. The sleeve 500 may deform the distal end to prevent blood clots captured by the stent body 100 from escaping to the outside of the stent body 100. The sleeve 500 may open and close the distal end of the stent body 100 by deforming the distal end. The sleeve 500 in the first state may open the distal end of the stent body 100. The sleeve 500 in the first state may be in the form of an open seal. The sleeve 500 in the first state may not interfere with the flow of blood flow through the distal end. The obstruction thrombus removal apparatus 1000 in the first state may allow the thrombus to enter the inside of the stent body 100 through the distal end. During the process of the thrombus entering the stent body 100, the thrombus may be fragmented and fragmented into small pieces. The sleeve 500 in the second state may close the distal end of the stent body 100. The sleeve 500 in the second state may be in the form of a closed seal. The obstruction thrombus removal apparatus 1000 in the second state may prevent movement of the thrombus through the distal end. In the second state, the obstruction thrombus removal apparatus 1000 may capture a thrombus or a fragmented thrombus. In the second state, the obstruction thrombus removal apparatus 1000 may prevent the outflow of the thrombus or the fragmented thrombus.

The sleeve 500 may have a tube shape with both ends open. One circumferential end of the sleeve 500 may form a proximal opening. The other circumferential end of sleeve 500 may form a distal opening. The diameter of the sleeve 500 may be similar to the diameter of the tube shape of the stent body 100. The sleeve 500 may be attached in a tube shape. The tube surface of the sleeve 500 may partially cover the tube shape of the stent body 100.

The sleeve 500 may be bent or folded to form a closed seal shape. The sleeve 500 may be an elastic body that can be folded or bent. The sleeve 500 may include a nickel titanium alloy or a material restored to a shape stored at a high temperature when heated, but is not limited thereto. The sleeve 500 may include an elastic polyurethane material or a polymer, but is not limited thereto. When the sleeve 500 includes an elastic polyurethane material, it may be formed on the distal portion of the stent body 100 through dip coating. The sleeve 500 may be adhered to the stent body 100 in a liquid state, and when solidified, the sleeve 500 in the form of a film liner may be formed around the stent body 100. The sleeve 500 may include a plurality of holes according to the characteristics of the material or post-processing. The size of the hole may be smaller than the size of the blood clot. The sleeve 500 in which the hole is formed may provide a passage for blood flow even in the second state in the form of a closed seal.

The sleeve 500 may be positioned inside the stent body 100 to prevent separation into blood vessels. According to some embodiments, the inner tube surface of the sleeve 500 may be connected to the outer surface of the stent body 100, and in this case, the sleeve 500 may be located outside the stent body 100.

Sleeve 500 may extend from a portion of proximal body 110 to distal body 120. Sleeve 500 may extend from a portion of proximal body 110 along the struts of distal body 120. Through this, only the distal portion of the sleeve 500 may be deformed along the distal body 120. According to some embodiments, sleeve 500 may be located only on distal body 120. In this case, the entire sleeve 500 may be deformed along the distal body 120.

The tube surface of the sleeve 500 may extend from one circumferential end to the other circumferential end. The sleeve 500 may extend from the first edge 510 to the second edge 520. The first edge 510 may be one of the circumferential ends of the sleeve. The second edge 520 may be the other one of the circumferential ends of the sleeve. The first edge 510 may be positioned proximal to the distal end of the proximal body 110, and the second edge 520 may be positioned proximal to the distal end of the distal body 120. According to some embodiments, both the first edge 510 and the second edge 520 may be located on the distal body 120. In this case, the first edge 510 may be positioned close to the proximal end of the distal body 120, and the second edge 520 may be positioned close to the distal end of the distal body 120.

The diameter of the first corner 510 may be similar to the diameter of the tube shape of the stent body 100. The first edge 510 may form a proximal opening. The first edge 510 may not be greatly deformed according to the movement of the wire 200. This may be because the first edge 510 is located on the proximal body 110 that is less affected by the movement of the wire 200. According to some embodiments, the first edge 510 may be located on the distal body 120. In this case, since the first edge 510 is located close to the proximal end of the distal body 120, a change in diameter due to the movement of the wire 200 can be minimized.

The second edge 520 may form a distal opening. The second edge 520 may be deformed through the wire 200. The diameter of the second edge 520 may decrease as the wire 200 moves. When the wire 200 moves, the distal body 120 of the stent body 100 may be partially deformed. Through this, the second edge 520 located on the distal body 120 may be deformed.

Hereinafter, an apparatus for removing clots in a first state or a second state according to an exemplary embodiment of the present specification will be described.

The obstruction thrombus removal apparatus 1000 in the first state is shown in FIG. 2.

The obstruction thrombus removal apparatus 1000 in the first state may be in a expanded and expanded state. The obstruction thrombus removal apparatus 1000 in the first state may be engaged with the thrombus. The stent body 100 may be engaged with a blood clot that has entered the bloodstream. In addition, a part of the thrombus may be fragmented during the process of digging into the thrombus and engaging the thrombus while the stent 100 is inflated. The fragmented thrombus may move to the outside of the stent body 100 through the distal end of the stent body 100. The sleeve 500 in the first state may not interfere with the movement of the blood clot through the distal end.

The sleeve 500 in the first state may have a first diameter at the second edge 500. The first diameter may be larger than the diameter of the wire 200. The diameter of the second edge 520 of the sleeve 500 in the first state may be larger than the diameter of the wire 200. The diameter of the second edge 520 in the first state may be similar to the diameter of the tube shape of the stent body 100. A gap may exist between the second edge 520 of the sleeve 500 in the first state and the wire 200. The stent body 100 in the first state may have a space formed between the struts 101 at the distal end. Through this, the blood clot may enter the stent body 100. The blood clot may exit from the stent body 100. In addition, the stent body 100 may minimize interference with blood flow that occurs when advancing.

The attachment point 130 in the first state may be located distal to the first edge 510. The attachment point 130 in the first state may be located closer to the central axis in the longitudinal direction of the stent body 100 than the first edge 510. The attachment point 130 in the first state may be located closer to the central axis in the longitudinal direction of the stent body 100 than the second edge 520. There may be a gap between the attachment point 130 in the first state and the second edge 520.

The wire 200 of the obstruction thrombus removal apparatus 1000 in the first state may be located at the first position. The ring 300 in the first state may not contact the distal end of the tubular member 400. The second ring 320 and the second ring 300 positioned distal to the tubular member 400 may be positioned at a distance from the tubular member. The first ring 310 positioned proximal to the tubular member 400 may contact the proximal end of the tubular member 400 according to the movement of the wire 200. The first ring 310 may limit the stent body 100 from being longer in the first state.

The obstruction thrombus removal apparatus 1000 in the second state is shown in FIG. 3.

The obstruction thrombus removal apparatus 1000 in the second state may be in an expanded state. The obstruction thrombus removal apparatus 1000 in the second state may prevent the outflow of the thrombus. The obstruction thrombus removal apparatus 1000 in the second state may be a process of recovering or recovering from the blood vessel. During the process of being recovered outside the blood vessel, the blood clot inside the stent body 100 may escape. The obstruction thrombus removal apparatus 1000 in the second state may prevent the thrombus from exiting the stent body 100. The sleeve 500 in the second state may close the distal end of the stent body 100. The sleeve 500 may prevent the outflow of blood clots by closing the space between the struts 101 at the distal ends.

The length of the obstruction thrombus removal apparatus 1000 in the second state may be shorter than the length of the obstruction thrombus removal apparatus 1000 in the first state. The length of the sleeve 500 in the second state may be shorter than the length of the sleeve 500 in the first state. The sleeve 500 in the second state may be bent or folded toward the inside of the stent body 100. At least a portion of the sleeve 500 may be deformed radially inward. At least a portion of the sleeve 500 may be folded into the stent body 100. At least a portion of the sleeve 500 may be located inside the stent body 100. The sleeve 500 located on the stent body 100 may have a partially basket shape. The sleeve 500 may directly prevent the flow of blood or blood clots through the lumen of the sleeve 500.

The sleeve 500 in the second state may have a second diameter at the second edge 500. The second diameter may be substantially zero or may be similar to the diameter of the wire 200. The diameter of the second edge 520 in the second state may be substantially zero or may be similar to the diameter of the wire 200. The diameter of the second edge 510 in the second state may be smaller than the diameter of the first edge 510. The second edge 520 may be bent toward the wire 200, and a gap may not exist between the second edge 520 and the wire 200. The thrombus cannot enter the stent body 100 through the second corner 520. The thrombus cannot exit the stent body 100 through the second edge 520.

The length of the stent body 100 in the second state may be shorter than the length of the stent body 100 in the first state. The distal body 120 in the second state may be deformed. The attachment point 130 in the second state may be located proximal to the first edge 510. The attachment point 130 in the second state may be located proximal to the second edge 520. The second edge 520 in the second state may be located proximal to the first edge 510. The attachment point 130 in the second state may be located closer to the central axis in the longitudinal direction of the stent body 100 than the first edge 510. The attachment point 130 and the second edge 520 in the second state may be located close to a straight line. The second edge 520 may be positioned closer to the center axis in the longitudinal direction of the stent body 100 than the first edge 510.

The wire 200 in the second state may be located in the second position. The wire 200 in the second state may be located proximal to the wire 200 in the first state. The ring 300 in the second state may be located proximal to the ring 300 in the first state. The ring 300 may not contact the proximal end of the tubular member 400. The first ring 310 may be positioned at a distance from the proximal end of the tubular member 400. Second The ring 320 may contact the distal end of the tubular member. The second ring 320 may limit the stent body 100 from being shorter in the first state.

Hereinafter, the stent body 100 of the obstruction thrombus removal device will be described in more detail.

4 is a view showing a part of an apparatus for removing clots according to a first embodiment of the present invention. Referring to FIG. 4, the stent body 100 includes a strut 101. Strut 101 may form a cell 103. Strut 101 may include an open cut strut 105. The open cut strut 105 may form an open cut, which is a divided form of the stent body 101, and a gap 107 may be formed between the pair of open cut struts 105.

Strut 101 may be one, and may be two or more. The number of struts 101 may be the same as the number of strands constituting the actual stent body 100. The number of struts 101 may be different from the number of strands. For example, one strand crosses the length direction of the stent body 100 four times to form the entire stent body 100. In this case, if a specific region of the entire stent body 100 is defined by two straight lines perpendicular to the length direction of the stent body 100, the number of struts 101 included in one region may be four.

The stent body 100 may have a divided shape. The divided shape refers to open or unconstrained, and may be formed by the stent body 100 containing less material-struts-in the circumferential direction. The divided form may be mainly included in a tubular portion of the stent body 100 in which the cells 103 are formed. The divided shape may be referred to as an open cut. The open cut may not include cells closed by struts 101. Each stent body 100 divided through an open cut may include a cell 103. The open cut may be formed in a spiral shape through the entire stent body 100 or may not be formed in a spiral shape. The open cut may be formed partially or discontinuously. Multiple open cuts that are discontinuously divided may have different angles.

As the number of materials included in the circumference of the stent body 100 is smaller, the flexibility of the stent body 100 may be improved. A divided shape such as an open cut may allow the stent body 100 to bend well around a blood vessel having less axial elongation and a tighter radius. In addition, a divided shape such as an open cut may change the diameter of the stent body 100 to fit a narrow or wide blood vessel. Through this, the stent body 100 can be well engaged with the target thrombus even in blood vessels of various sizes.

When the open cut is configured in a spiral shape throughout the stent body 100, the open cut may include at least one open cut strut 105 located in a spiral around the longitudinal direction. Open cut struts 105 may be at least one pair. The open cut strut 105 may rotate around the longitudinal direction of the stent body 100 through at least one turn. Specifically, the open cut strut 105 may extend from the stent body 100 or the tube-shaped proximal end to the distal end over the stent body 100 or the tube-shaped axial length, and the open cut strut 105 is a stent body. It can rotate around the longitudinal direction over the (100) or tubular axial length.

A gap 107 may be defined between the stent body 100 or the open cut struts 105 spanning the tubular axial length. One open cut strut 105 of the pair of open cut struts 105 may be disconnected from the other open cut strut 105. A gap 107 may be formed between the pair of open cut struts 105 disconnected from each other. The gap 107 may be located in a spiral shape. The gap 107 may include at least one turn. In accordance with some embodiments, the gap 107 may not be helical.

The proximal end and the distal end of the open cut strut 105 may not have a connection point that is connected to other parts of the stent body 100. For example, when the open cut strut 105 is located in a tube shape, the proximal end of the open cut strut 105 may not have a connection point connected to the basket shape, and the distal end of the open cut strut 105 is It may not have a connection point to connect with the basket shape. In addition, even when the proximal end or the distal end of the open cut strut 105 has respective connection points, each connection point may not have a separate element connecting them. Through this, the open cut struts 105 of the stent body 100 can move freely over the length of the gap 107, and the width of the gap 107 can be changed as the stent body 100 expands or contracts. .

The gap 107 may be composed of partial or discontinuous segments. The stent body 100 or tube shape may include one gap 107 over an axial length, or may include a plurality of gaps divided into a plurality of segments. The divided gap may be helical and may extend over an axial length of the stent body 100 or tubular shape. For example, each divided gap may rotate around the length direction of the stent body 100. According to some embodiments, the divided gaps may have different angles.

In accordance with some embodiments, the open cut may include a connector. The connector may extend between the open cut struts 105 to bridge the gap 107. The location of the connector may be between the proximal and distal ends of the open cut strut 105 or gap 107. For example, if the connector is located in the center of the open cut strut 105 or the gap 107, the divided gaps may have the same length. The connector may be located proximal or distal to the center of the open cut strut 105 or gap 107, with one of the divided gaps being longer than the other.

There may be more than one connector, and multiple connectors may connect gaps 107 at different locations along the helical profile. For example, the connector If two, so that the length of the three segmented gaps (proximal of the first connector, between the first and second connectors, distal of the second connector) defined by the first and second connectors are equal-the entire gap (107) One-third of the length-each connector can be positioned. Based on this, the gap 107 or other configuration of the divided gap may be considered by those skilled in the art.

Although not shown, the stent body 100 may ensure visibility under x-ray. Although not shown, the stent body 100 may include a marker. The marker may include platinum, a platinum iridium alloy, or other material with high visibility under x-ray. The user may check the location or shape of the obstruction thrombus removal device 1000 through the marker under the x-ray. In addition, visibility of the obstruction thrombus removal apparatus 1000 may be improved by winding or tying the visibility wire around the stent body 100.

The marker may be partially located on the stent body 120. The marker may be located on the distal body 120 of the stent body 100. When the distal body 120 is deformed according to the movement of the wire 200, the user can check the deformed shape of the distal body 120 through a marker. For example, the marker may be located in a first position and a second position of the distal body 120. The marker at the first position and the marker at the second position are spaced apart in the first state and may correspond in the second state. The marker at the first position and the marker at the second position may be positioned in a straight line in the second state. The user can check whether the distal body 120 is deformed according to whether the markers at the first position and the second position correspond.

The marker may be included in the stent body 100 as well as the wire 200, the ring 300, the tubular member 400, or the sleeve 500 of the obstruction thrombus removal device 1000. In addition, the marker may be included in these other additional components when the obstruction thrombus removal apparatus 1000 includes other additional components such as an umbrella or an internal stent body.

The stent body 100 may include an outer coating or deposition, and the outer coating or deposition may include platinum, a platinum iridium alloy, or other material with high visibility under x-ray. The outer coating or vapor deposition can be formed through electroplating, sputtering or powder coating. External coating or deposition may be included in the entire stent body 100. The external coating or deposition may be included in the stent body 100 as well as the wire 200, the ring 300, the tubular member 400, or the sleeve 500 of the obstruction thrombus removal device 1000. In addition, external coating or deposition may be included in these other additional components when the obstruction thrombus removal apparatus 1000 includes other additional components such as an umbrella or an internal stent body.

Hereinafter, a modified example of the obstruction thrombus removal apparatus according to the first embodiment will be described with reference to the drawings.

5 is a view showing a modified example of the obstruction thrombus removal apparatus according to the first embodiment of the present invention, and FIG. 6 is a diagram showing an internal stent body of a modified example of the obstruction thrombus removal apparatus according to the first embodiment of the present invention It is a drawing shown.

5 and 6, the obstruction thrombus removal apparatus 1000 may include an umbrella 600 or an internal stent body 700.

The umbrella 600 may capture fragmented blood clots moving upstream of a blood vessel. The umbrella 600 may be connected to the most distal portion of the wire 200 to collect fragmented blood clots moving upstream of the blood vessel.

In the umbrella 600, the sleeve 500 may include a nickel titanium alloy or a material restored to a shape stored at a high temperature when heated, but is not limited thereto. The umbrella 600 may include an elastic polymer (eg, polyurethane), but is not limited thereto. The umbrella 600 may include a nickel titanium alloy material in which an elastic polymer (eg, polyurethane) is disposed. The umbrella 600 may have a shape that tapers radially outward. The umbrella 600 may include a hole. The umbrella 600 may prevent blood clots from passing through the holes through a separate layer-for example, an elastic polymer.

The umbrella 600 may be manufactured through a manufacturing method such as laser cutting, micro machining, electrical discharge machining (EDM), and braiding.

The umbrella 600 may have the shape of an umbrella. The diameter of the umbrella 600 may not be constant. The umbrella 600 may have a minor diameter at the proximal portion and a major diameter at the distal portion. The proximal portion of the umbrella 600 having a minor diameter may be connected to the distal portion of the wire 200 through welding or brazing (brazing).

The internal stent body 700 may create a low level of reperfusion before the obstruction thrombus removal device 1000 captures the target thrombus and is removed from the blood vessel. The internal stent body 700 may provide a passage for blood flow through the obstruction thrombus removal device 1000. The internal stent body 700 may provide a passage for blood flow through the target blood clot.

The inner stent body 700 may include a strut 701. Strut 701 may be a line or a post. There may be one strut 701. There may be two or more struts 701. The strut 701 may form an internal stent body 700 by forming an intersection.

The strut 701 may form a cell 703. Cell 703 may be an area closed by struts 701. The cell 703 may be a closed area through a connection between the struts 701. The cell 703 may be located on the side surface of the inner stent body 700.

The internal stent body 700 may be made of a material having properties similar to those of the stent body 100. The inner stent body 700 may be an elastic body. The internal stent body 700 is provided as an elastic body, so that it can be deformed between a contracted state and an expanded state. The internal stent body 700 may include a nickel titanium alloy or a material restored to a shape stored at a high temperature when heated. The inner stent body 700 is provided with an elastic body, such that the inner stent body 700 is laser cutting, micro machining, electrical discharge machining (EDM), and braiding. It can be manufactured through a manufacturing method.

The internal stent body 700 may prevent a target blood clot from entering the interior, thereby providing a passage for blood flow. The size of the cell 703 of the internal stent body 700 may be smaller than the size of the cell 101 of the stent body 100. The size of the cell 703 of the internal stent body 700 may be smaller than the size of a general target blood clot.

The internal stent body 700 may be located inside the stent body 100 to provide a passage for blood flow. The diameter of the inner stent body 700 may be smaller than the diameter of the stent body 100. The inner stent body 700 may be located at the inner diameter of the stent body 100 and may be located inside the stent body 100. The central axis of the internal stent body 700 may coincide with the central axis of the obstruction thrombus removal apparatus 1000. The central axis of the internal stent body 700 may coincide with the central axis of the stent body 100.

The deformation of the sleeve 500 may vary depending on the position of the internal stent body 700 in the stent body 100. When the second edge 520 of the sleeve 500 enters the inside of the stent body 100 according to the movement of the wire 200, the second edge 520 of the sleeve 500 and the inner stent body 700 You can get closer. Deformation of the sleeve 500 may be limited through interference between the inner stent body 700 and the second edge 520.

When the inner stent body 700 is in the first inner position, the second edge 520 may be positioned at the distal end of the inner stent body 700. In this case, the diameter of the second edge 520 and the diameter of the inner stent body 700 may be similar. The diameter of the second edge 520 may be a value between the diameters of the first state and the second state.

If the inner stent body 700 is distal to the first inner position, the diameter of the second edge 520 cannot be reduced than the diameter of the inner stent body 700 according to the movement of the wire 200. The sleeve 500 may partially close the distal end of the stent body 100. The distal end may be opened as much as the cross-sectional area of the inner stent body 700. Through this space, the blood clot may escape from the internal stent body 700 or the blood clot may enter the internal stent body 700.

If the inner stent body 700 is proximal to the first inner position, the diameter of the second edge 520 may be smaller than the diameter of the inner stent body 700 as the wire 200 moves. As the wire 500 moves, the diameter of the second corner 520 may be reduced to the second corner diameter 520 in the second state. The sleeve 500 may form a closed seal to close the distal end of the stent body 100. The thrombus cannot escape from the stent body 100 or the internal stent body 700 through the distal terminal.

The wire 200 may be located in the inner diameter of the inner stent body 700. A wire 200 may be located inside the inner stent body 700. The central axis of the inner stent body 700 may coincide with the central axis of the wire 200.

The wire 200 may not be located in the inner diameter of the inner stent body 700. The internal stent body 700 may replace the wire 200. The inner stent body 700 may be designed to deform a part of the stent body 100 through longitudinal movement.

The inner stent body 700 may be connected at the distal and proximal portions of the stent body 100, respectively. The internal stent body 700 may be connected to the wire 200. The internal stent body 700 may be connected to the wire 200 through mechanical locks, welding, soldering (soldering) or brazing (brazing).

Hereinafter, the operation of the obstruction thrombus removal apparatus according to the first embodiment will be described with reference to the drawings.

Referring to FIG. 7, the apparatus 1000 for removing clots according to the first embodiment may change from a first state to a second state. The obstruction thrombus removal apparatus 1000 may be moved by the wire 200 in the second state.

The downward arrow shown in FIG. 7 shows the order of operations of the obstruction thrombus removal apparatus 1000. Referring to the first drawing located at the top of FIG. 7, the obstruction thrombus removal apparatus 1000 may be in a first state. What is indicated by a double arrow may be a distance between the second ring 320 and the tubular member 400. The distance between the second ring 320 and the tubular member 400 may correspond to a distance between the deformation section of the wire 200. Referring to the second drawing from the top of FIG. 7, the wire 200 may be located within the deformation section. At this time, the distance between the second ring 320 and the tubular member 400 may be closer than in the first drawing of FIG. 7. Referring to the third drawing from the top of FIG. 7, the obstruction thrombus removal apparatus 1000 may be in a second state. The wire 200 may be located at the end of the deformation section. The second ring 320 and the tubular member 400 may abut. Referring to the fourth drawing located at the bottom of FIG. 7, the obstruction thrombus removal apparatus 1000 may move according to the movement of the wire 200. The distance and direction the obstruction thrombus removal device 1000 has moved is shown by an arrow pointing to the left.

Referring to FIG. 8, the apparatus 1000 for removing clots according to the first embodiment may change from a first state to a second state. The arrows shown in FIG. 8 indicate a sequence of operations of the obstruction thrombus removal apparatus 1000. A drawing located at the upper left of FIG. 8 shows a first state of the obstruction thrombus removal apparatus 1000. The operation of the obstruction thrombus removal apparatus 1000 that changes from the first state to the second state is illustrated in a clockwise direction from a drawing located at the upper left. A drawing located at the lower left of FIG. 8 shows a second state of the obstruction thrombus removal apparatus 1000.

The attachment point 130 may be located in a straight line with the ring 300 and the tubular member 400. The attachment point 130 may be moved from distal to proximal from the first state to the second state. Through this, at least a portion of the distal body 120 of the stent body 100 in the second state may be deformed radially inward. At least a portion of the distal body 120 of the stent body 100 may be folded inward of the stent body 100. In this case, the proximal body 110 may not be substantially deformed. The stent body 100 may not be substantially moved.

The ring 300 may be moved in position from distal to proximal from the first state to the second state. The ring 300 may be located at the most distal position in the first state, and may be located at the most proximal position in the second state. The ring 300 in the second state may be in contact with the tubular member 400, and the wire 200 may be located in the second position. Through this, the degree of deformation of the stent body 100 may be limited. Through this, stretching of the stent body 100 may be prevented.

When the wire 200 moves from the first position to the second position, the attachment point 130 of the stent body 100 may change from the first state to the second state. When the wire 200 is located inside the stent body 100, the attachment point 130 is also located inside the stent body 100, and a portion of the strut 101 of the distal body 120 is attached to the attachment point 130. Accordingly, it may be moved to the inside of the stent body 100. The sleeve 500 can be deformed radially inward with at least a portion of the sleeve 500 along the strut 101 of the distal body 120. At least a portion of the sleeve 500 may be folded into the stent body 100. The sleeve 500 may form a closed seal at the distal end of the stent body 100 through mechanical interference. The sleeve 500 may limit movement of a material through the distal end of the stent body 100 by eliminating mechanical interference.

When the wire 200 moves from the first position to the second position, the second edge 520 may be transformed from the first state to the second state along the strut 101 of the distal body 120. When a part of the strut 101 of the distal body 120 enters the inside of the stent body 100 according to the movement of the wire 200, the second edge 520 may be located inside the stent body 100. . The diameter of the second edge 520 may be the largest in the first state and may be the smallest in the second state. The second edge 520 may be moved close to the wire 200 and may be moved radially inward. Each point on the second edge 520 may be moved to be adjacent to the wire 200. When the central axis of the wire 200 and the central axis of the stent body 100 are common, each point on the second edge 520 may be moved toward the central axis of the stent body 100. The distance between each point on the second edge 520 may be shortened. The diameter of the second edge 520 of the sleeve 500 may be reduced from the first state to the second state. The diameter of the second edge 520 of the sleeve 500 may be reduced as the second ring 320 moves toward the tubular member 400. Here, when the wire 200 is positioned at the second position, the diameter of the second edge 520 is substantially zero or similar to the diameter of the wire 200, so that the distal end of the stent body 100 may be closed.

According to some embodiments, the sleeve 500 may be located only on the distal body 120 and not on the proximal body 110. Alternatively, even when the sleeve 500 is positioned across the proximal body 110 and the distal body 120, a part of the proximal body 110 may be designed to be bent inward like the distal body 120. In this case, as the wire 200 moves from the first position to the second position, the entire sleeve 500 may be located inside the stent body 100. The sleeve 500 may have a basket shape. The sleeve 500 may partially cover the distal end of the stent body 100. The sleeve 500 may cover the central region of the distal end of the stent body 100. The sleeve 500 may open an edge region of the distal end of the stent body 100.

According to some embodiments, when the entire sleeve 500 can be brought into the inside of the stent body 100, the first corner 510 may be located inside the stent body 100 according to the movement of the wire 200. have. In this case, the diameter of the first corner 510 may be smaller than the diameter of the tube shape of the stent body 100. The blood clot may enter the stent body 100 through the radially outer space of the first corner 510. The thrombus may exit from the stent body 100 through the radially outer space of the first corner 510.

The ring 300 may limit the movement of the wire 200 relative to the stent body 100 so that the sleeve 500 is not deformed further than that closed at the distal end of the stent body 100. As the moving distance of the wire 200 is limited, a change in length of the stent body 100 may be limited.

When the ring 300 is located distal to the tubular member 400, the ring 300 may limit the stent body 100 in the second state deformed in the first state so that the stent body 100 is not further deformed. When the wire 200 moves from the first position to the second position, the ring 300 may be close to the tubular member 400. When the ring 300 contacts the tubular member 400, the wire may be temporarily fixed to the stent body 100. At this time, at least a portion of the stent body 100 and the sleeve 500 may be limited from being deformed radially inward.

Even when the sleeve 500 is designed to be able to enter the stent body 100 as a whole according to some embodiments, the ring 300 may limit the degree of deformation of the sleeve 500 as described above. The deformation of the sleeve 500 by the ring 300 may be variously changed according to the position or number of the rings 300 described above.

7 and 8, the obstruction thrombus removal apparatus 1000 in the first state may be transformed into the occlusion thrombus removal apparatus 1000 in the second state, and then may be moved by the wire 200. When the ring 300 contacts the tubular member 400, the wire 200 and the proximal end of the stent body 100 may be temporarily fixed. The wire 200 may move the entire stent body 100 by interference between the ring 300 and the tubular member 400. The direction in which the wire 200 moves the stent body 100 may be a direction in which the wire 200 moves from the first position to the second position. Specifically, it may be a proximal direction.

The obstruction thrombus removal apparatus 1000 according to the first exemplary embodiment illustrated in FIGS. 7 and 8 may be operated in an order opposite to that described above. The obstruction thrombus removal apparatus 1000 according to the first exemplary embodiment may change from the second state to the first state.

When the wire 200 moves from the second position to the first position, the attachment point 130 of the stent body 100 may change from the second state to the first state. At least a portion of the distal body 120 of the stent body 100 along the attachment point 130 may be deformed radially outward. At least a portion of the sleeve 500 along the strut 101 of the distal body 120 may be deformed radially outward. At least a portion of the sleeve 500 along the strut 101 of the distal body 120 may be unfolded outward of the stent body 100. The sleeve 500 may open the distal end of the stent body 100 by solving mechanical interference to provide a passage for a substance.

When the wire 200 moves from the second position to the first position, the second edge 520 may move from the second state to the first state along the strut 101 of the distal body 120. When a portion of the strut 101 of the distal body 120 is spread outward of the stent body 100 according to the movement of the wire 200, the second edge 520 may not be located inside the stent body 100. I can. The diameter of the second edge 520 may be similar to the diameter of the tube shape of the stent body 100. The distal end of the stent body 100 may be opened. The thrombus may enter the stent body 100 through the second corner 520. The thrombus may exit from the stent body 100 through the second edge 520.

When the ring 300 is located proximal to the proximal end of the stent body 100, the ring 300 is limited so that the stent body 100 in the first state deformed in the second state is not further deformed. can do. When the wire 200 moves from the second position to the first position, the ring 300 may become close to the tubular member 400. When the ring 300 contacts the tubular member 400, the wire may be temporarily fixed to the stent body 100. At this time, at least a portion of the stent body 100 and the sleeve 500 may be limited from being deformed radially inward.

Hereinafter, a method of removing an occluded thrombus using the above-described device will be described.

FIG. 9 is a diagram illustrating a procedure of a method for removing an occlusive thrombus according to a first embodiment of the present invention, and FIG. 10 is a diagram illustrating a procedure of a method for removing an occlusive thrombus according to a first embodiment of the present invention.

9 and 10, a method (S1000) of removing an occluded thrombus according to the first embodiment is as follows.

A method of removing an obstructive thrombus according to the first exemplary embodiment includes the steps of inserting a constricted obstructive thrombus removal device into a blood vessel (S1100); Inflating the closed thrombus removal device in a contracted state to a deployed state in the blood vessel (S1200); A step (S1300) in which the apparatus for removing clots in the deployed state is in a first state; A step (S1400) in which the apparatus for removing clots in a deployed state is in a second state; And recovering the obstruction thrombus removal device from the blood vessel (S1500).

Hereinafter, each step will be described in more detail.

The obstruction thrombus removal apparatus 1000 may be inserted into a blood vessel (S1100). The obstruction thrombus removal apparatus 1000 may be in a constricted form. The obstruction thrombus removal apparatus 1000 may be in a constricted state by a tubular member such as a catheter. The user may place the obstruction thrombus removal apparatus 1000 at a target position. The user may position the obstruction thrombus removal device 1000 in proximity to the target blood clot.

The obstruction thrombus removal apparatus 1000 may expand and deploy in a blood vessel (S1200). When a tubular member such as a catheter surrounding the occlusive thrombus device is recovered distally, the catheter may not restrain the occlusive thrombus device 1000. Through this, the obstruction thrombus removal apparatus 1000 may expand itself. The obstruction thrombus removal apparatus 1000 may apply a force radially outward through expansion. The obstruction thrombus removal apparatus 1000 may expand to fit the size of a blood vessel.

The stent body 100 may be engaged with the blood clot during the process of expanding the obstruction thrombus removal device 1000. The stent body 100 may penetrate the blood clot, and at this time, a part of the blood clot may be fragmented by the strut 101 of the stent body 100.

The deployed obstruction thrombus removal apparatus 1000 may be in a first state (S1300). The obstruction thrombus removal apparatus 1000 in the first state may engage with the thrombus. The strut 101 of the stent body 100 may be fixed so that the blood clot cannot escape. The fragmented thrombus may be located inside the obstructive thrombus removal device. The stent body 100 may capture blood clots that have entered the stent body 100.

The obstruction thrombus removal apparatus 1000 in the first state may open a distal end of the sleeve 500 to provide a passage for a substance. The thrombus inside the stent body 100 may move to the outside through the distal end of the sleeve 500. The stent body 100 may provide a passage for a material through a gap between the sleeve 500 and the wire 200. At this time, the ring 300 located distal to the tubular member 400 may be positioned at a distance from the tubular member 400.

The deployed obstruction thrombus removal apparatus may be in a second state (S1400). As illustrated in FIG. 10, the obstruction thrombus removal apparatus 1000 in the second state may collect the thrombus. The internal space of the stent body 100 may accommodate a blood clot. The sleeve 500 in the second state may form a closed seal form at the distal end of the stent body 100 to close the distal end of the stent body 100. The sleeve 500 may prevent blood clots from escaping from the stent body 100. The closed seal may be formed by moving the wire 200 in the proximal direction, thereby bending the distal portion of the sleeve 500 toward the inside of the stent body. A closed seal may cover a gap between the sleeve 500 and the wire 200. The material inside the stent body 100 cannot move to the outside of the stent body 100 through a closed seal. At this time, the ring 300 located distal to the tubular member 400 may contact the tubular member 400.

The obstruction thrombus removal apparatus 1000 may be recovered from a blood vessel (S1500). The user may take out the engaged thrombus out of the blood vessel by recovering the obstruction thrombus removal device 1000. The user may take out the collected thrombus out of the blood vessel by collecting the obstruction thrombus removal device 1000. The collected obstruction thrombus removal apparatus 1000 may be in a second state. The obstruction thrombus removal apparatus 1000 in the second state may prevent the thrombus from escaping through the modified sleeve 500. By the ring 300 located distal to the tubular member 400 in contact with the tubular member 400, the proximal end of the stent body 100 may be fixed to the wire 200.

Hereinafter, an apparatus for removing clots according to a second embodiment will be described.

The obstruction thrombus removal apparatus according to the second embodiment is the same as that of the first embodiment except for those mentioned below. Therefore, in the description of the second embodiment, the same reference numerals are assigned to the configurations common to those of the first embodiment, and detailed descriptions are omitted.

The obstruction thrombus removal apparatus according to the second embodiment may be engaged with the thrombus and capture the fragmented thrombus. The obstruction thrombus removal apparatus according to the second embodiment may pass through a serpentine vascular structure.

In detail, the obstruction thrombus removal apparatus according to the second exemplary embodiment may be engaged with a thrombus by applying force to a divided body through movement of a wire, and may capture the thrombus. The obstruction thrombus removal apparatus according to the second exemplary embodiment may pass through a serpentine vascular structure by improving the flexibility of the device through the divided body.

The obstruction thrombus removal apparatus according to the second embodiment may include two bodies capable of capturing blood clots, a wire for moving the body, a ring and a tubular member for restricting movement of the wire.

Hereinafter, each component will be described in detail.

11 and 12 are diagrams showing an apparatus for removing a clot in a first state according to a second embodiment of the present invention, and FIGS. 13 and 14 are views showing a clot in a second state according to the second embodiment of the present invention. FIG. 15 is a view showing a removal device, and FIG. 15 is a view showing a marker of the obstruction thrombus removal device according to a second embodiment of the present invention.

Referring to FIGS. 11 to 15, the apparatus 1000 for removing clots according to the second embodiment includes a stent body 100, a wire 200, a ring 300, and a tubular member 400.

The stent body 100 may accommodate blood clots in the internal space. The stent body 100 may include a proximal body 110 and a distal body 120 capable of receiving blood clots therein.

The stent body 100 may not be an integral type. The stent body 100 may have a form in which the proximal body 110 and the distal body 120 are separated.

The proximal body 110 and the distal body 120 may have a basket shape. The proximal body 110 and the distal body 120 may have a tube shape.

The proximal body 110 may have a conical shape or a dome shape at the proximal end. The diameter of the proximal portion of the proximal body 110 may become narrower toward the proximal end. The diameter of the distal end of the proximal body 110 may be larger than the diameter of the proximal end. The distal end of the proximal body 110 may be tapered radially outward to swallow the target thrombus. The distal end of the proximal body 110 may be provided in a ring shape. The ring can minimize damage to blood vessels through the distal end of the proximal body 110.

The distal body 120 may have a conical shape or a dome shape at the proximal end and the distal end, respectively. The diameter of the proximal portion of the distal body 120 may become narrower toward the proximal end. The diameter of the distal portion of the distal body 120 may become narrower toward the distal end. By narrowing the diameter, the proximal end of the distal body 120 can be easily engaged with the target thrombus. The narrow diameter of the distal end of the distal body 120 may prevent the captured thrombus from escaping. The cells at the distal portion of the distal body 120 may be smaller than the cells of the stent body 100. The distal portion of the distal body 120 includes a cell having a small size, thereby preventing the captured blood clot from escaping.

The proximal body 110 and the distal body 120 may be connected at a distance. The proximal body 110 and the distal body 120 may be connected with a minimum of materials or a simplified structure. A wire 200 connecting two components may be positioned between the proximal body 110 and the distal body 120. Since the proximal body 110 and the distal body 120 are positioned at a distance, the flexibility of the stent body 100 can be maximized. Since the proximal body 110 and the distal body 120 are connected at a distance, the obstruction thrombus removal apparatus 1000 may pass through the anatomical structure without missing the enclosed thrombus.

A target thrombus may be located between the proximal body 110 and the distal body 120. When the target blood clot is located between the proximal body 110 and the distal body 120 and the distance between the proximal body 110 and the distal body 120 is reduced, the target blood clot can be easily engaged with the stent body 100 . When the target blood clot is located between the proximal body 110 and the distal body 120 and the distance between the proximal body 110 and the distal body 120 is reduced, the target blood clot can be well captured by the stent body 100. Details will be described later.

It is preferable that the obstruction thrombus removal apparatus 1000 can pass through a meandering blood vessel due to its anatomical structure. The serpentine blood vessel may include a corner in which the axial direction changes abruptly and a section in which the diameter changes abruptly. Since the proximal body 110 and the distal body 120 are separated, flexibility in the longitudinal direction or expansion in the radial direction of the stent body 100 may be improved. The proximal body 110 and the distal body 120 may be connected through an initial manufacturing process. The level of flexibility or expansion of the stent body 100 may vary according to a material or method for connecting the components. The proximal body 110 and the distal body 120 may be connected using less material or less interlocking fabrication methods to maximize flexibility between the two components. The connections between the components can be formed through mechanical locks, welding, soldering (soldering) or brazing (brazing).

The stent body 100 may include a marker 190. The marker 190 may be similar to that described in the first embodiment. The marker 190 may include a material that is visible under x-ray. The marker 190 may be spherical or cylindrical. The marker 190 may be attached to the stent body 100 at a proximal or distal portion.

The wire 200 may transmit a user's force to the stent body 100. The wire 200 may be positioned along the central axis of the stent body 100 to support the stent body 100. The wire 200 may be connected to the stent body 100. The wire 200 may move the stent body 100.

The wire 200 may be connected to each of the proximal body 110 and the distal body 120. The wire 200 may be fixed to the proximal end of the distal body 120. The distal end of the wire 200 may be fixed to the proximal end of the distal body 120. The wire 200 may be slidably connected to the proximal end of the proximal body 110. The wire 200 may be slidably connected to the proximal end of the proximal body 110 through a separate member. The separate member may be a tubular member 400.

The wire 200 may shorten or extend the distance between the proximal body 110 and the distal body 120. The wire 200 may move the position of the distal body 120. The wire 200 may move the distal body 120 toward the proximal body 110. The target thrombus may be located between the proximal body 110 and the distal body 120. The wire 200 may move the distal body 120 to apply a force to the target blood clot. An open invitation through which a blood clot may enter may be provided between the proximal body 110 and the distal body 120. A drop zone through which a blood clot can enter may be provided between the proximal body 110 and the distal body 120. The size of the open invitation or drop zone may be similar to the size of a normal blood clot. The size of the open invitation or drop zone may be larger than the size of a normal blood clot.

The ring 300 may limit the movement of the wire 200 by contacting a separate member that is not fixed to the wire 200. Ring 300 may limit movement of distal body 120. The ring 300 may prevent excessive compression of the target thrombus by limiting the movement of the wire 200 relative to the distal body 120.

The ring 300 may temporarily fix the wire 200 and the stent body 100. When the ring 300 contacts a separate member, the proximal end of the stent body 100 may be temporarily fixed to the wire 200. The wire 200 transmits force to the distal body 120 through the distal end of the wire 200, and the ring 300 transmits the force to the proximal body 110, so that the wire 200 and the ring 300 Silver stent body 100 can be prevented from being excessively deformed.

The tubular member 400 may slidably connect between the stent body 100 and the wire 200. The tubular member 400 may be fixed to the proximal end of the proximal body 110, and the tubular member 400 may be slidably connected to the wire 200. The tubular member 400 may be located in a straight line with the ring 300. When the tubular member 400 contacts the ring 300, the movement of the wire 200 may be restricted. The tubular member 400 may be a proximal end of the proximal body 110.

The first state may be a state in which a space for receiving a target thrombus is provided between the proximal body 110 and the distal body 120. The first state is shown in FIGS. 11 and 12. The second state may be a state in which a target blood clot is captured because the distance between the proximal body 110 and the distal body 120 is reduced. The second state is shown in FIGS. 13 and 14.

The proximal body 110 and the distal body 120 in the first state may be positioned at a distance. The distal end of the proximal body 110 may be positioned proximal to the proximal end of the distal body 120.

The ring 300 in the first state may not contact the distal end of the tubular member 400. When the ring 300 is located proximal to the tubular member 400, the ring 300 may contact the proximal end of the tubular member 400. When the ring 300 is located distal to the tubular member 400, the ring 300 may be located at a distance from the tubular member. The tubular member 400 may be a proximal end of the stent body 100.

The proximal body 110 and the distal body 120 in the second state may partially overlap. The distal end of the proximal body 110 may be located distal than the proximal end of the distal body 120. The proximal end of the distal body 120 may be located inside the proximal body 110.

The wire 200 in the second state may be located proximal to the wire 200 in the first state. The wire 200 in the first state may move proximal and be positioned as the wire 200 in the second state.

The ring 300 in the second state may be located proximal to the ring 300 in the first state. The ring 300 may not contact the proximal end of the tubular member 400. When the ring 300 is located proximal to the tubular member 400, the ring 300 may be located at a distance from the proximal end of the tubular member 400. When the ring 300 is located on the distal end of the tubular member 400, the ring 300 may contact the distal end of the tubular member. The tubular member 400 may be a proximal end of the proximal body 110.

The obstruction thrombus removal apparatus 1000 may be transformed from a first state to a second state according to a user's manipulation. In addition, the obstruction thrombus removal apparatus 1000 may be transformed from a second state to a first state according to a user's manipulation.

The obstruction thrombus removal apparatus 1000 in the first state may be transformed into the obstruction thrombus removal apparatus 1000 in the second state according to the proximal movement of the wire 200.

When the wire 200 moves in the proximal direction, the distal body 120 connected to the wire 200 may move in the proximal direction. The distal body 120 can move toward the proximal body 110. The distal body 120 may partially overlap the proximal body 110. The proximal end of the distal body 120 in the first state located distal to the distal end of the proximal body 110 is moved to be located proximal to the distal end of the proximal body 110 according to the movement of the wire 200 Can be.

When the target thrombus is located in the proximal body 110 and the distal body 120 and movement of the distal body 120 is restricted, the distal body 120 may be positioned at a distance from the proximal body 110. When the distance between the proximal body 110 and the distal body 120 decreases, pressure may be applied to the target thrombus and the target thrombus may be moved. The moved thrombus can be effectively engaged between the proximal body 110 and the distal body 120.

Movement of the distal body 120 may be limited through interference between the ring 300 and the proximal end of the proximal body 110. The ring 300 may be located at the proximal end of the proximal body 110 or distal of the tubular member 400. The ring 300 may move proximally according to the proximal movement of the wire 200. The ring 300 may limit the moving distance of the wire 200 by contacting the proximal end of the proximal body 110 or the tubular member 400.

The above-described characteristics of the separation and integration of the proximal body 110 and the distal body 120 may be referred to as an active integrated configuration.

Hereinafter, an apparatus for removing clots according to a third embodiment will be described.

The obstruction thrombus removal apparatus according to the third embodiment is the same as the first or second embodiment except for those mentioned below. Accordingly, in describing the third embodiment, the same reference numerals are assigned to the configurations common to those of the first embodiment or the second embodiment, and detailed description is omitted.

16 is a diagram showing an apparatus for removing clots according to a third embodiment of the present invention. Referring to FIG. 16, the apparatus 1000 for removing clots according to the third embodiment may include a stent body 100 and a wire 200.

The stent body 100 may include a proximal body 110 and a distal body 120.

The distal body 120 may provide a passage for blood flow. The distal body 120 may limit the movement of the blood clot. The distal body 120 may capture fragmented blood clots in place of the closed seal of the first embodiment. The distal body 120 may conform to the contraction and expansion of the stent body 100.

The distal body 120 may be an elastic body. Since the distal body 120 is provided as an elastic body, the distal body 120 may conform to the contraction and expansion of the obstruction thrombus removal device 1000. The distal body 120 may include a nickel titanium alloy or a material that restores a shape stored at a high temperature when heated. The distal body 120 may be manufactured through a manufacturing method such as laser cutting, micro machining, electrical discharge machining (EDM), and braiding.

The distal body 120 may include a distal strut 121. The distal strut 121 may be a line or a post. The distal strut 121 may be one. The distal strut 121 may be more than one. The distal strut 121 may form the distal body 120 by forming an intersection. The distal strut 121 may have a diameter smaller than that of the strut 101 of the stent body 100.

The distal strut 121 may form a distal cell 123. The distal cell 123 may be smaller than the size of the cell 103 of the stent body 100. The size of the distal cell 123 may be smaller than that of a general blood clot. Through this, the distal cell 123 may prevent the blood clot from escaping from the distal end of the stent body 100 instead of the closed seal of the first embodiment.

The distal ends of the distal body 120 may be gathered at one point. The distal end of the distal strut 121 may be gathered at the attachment point 130. The attachment point 130 may be surrounded by a separate configuration such as a tip.

The stent body 100 may be integral. The proximal end of the distal body 120 may be connected to the proximal body 110 through a connection point 140. The connection point 140 may be connected to at least one of the distal struts 121. When the number of connection points 140 is less than the number of distal struts 121, at least one connection point 140 may be connected to two or more distal struts 121. When the number of connection points 140 is less than the number of distal struts 121, the amount of material (material) located on the circumference of the stent body 100 may be less. Since the stent body 100 contains less material in its circumference, flexibility in the longitudinal direction may be improved.

The connection point 140 may be formed as a line. At this time, the proximal end of the connection line may be connected to the proximal body 110, and the distal end of the connection line may be connected to the distal body 120.

The wire 200 may not be located inside the stent body 100. The wire 200 may be located outside the stent body 100. The wire 200 may be connected to the proximal end of the stent body 100. The wire 200 may transmit a force to the stent body 100 through the proximal end of the stent body 100.

In the above, the configuration and features of the present invention have been described based on the embodiments according to the present invention, but the present invention is not limited thereto, and various changes or modifications can be made within the spirit and scope of the present invention. It will be apparent to those skilled in the art, and therefore, such changes or modifications are found to belong to the appended claims.

The form for carrying out the present invention may include the best form for carrying out the above-described invention, and related matters are described in the best form for carrying out the invention.

Claims

A self-expandable body including a proximal portion having a tubular shape formed through a plurality of first struts and a distal portion having a basket shape formed through a plurality of second struts-each of the second struts is self-expanding at the distal end of the proximal portion Extends to the attachment end configured to move along the longitudinal central axis of the body as possible; And

A sleeve mounted inside the self-expandable body and defining a surface extending along the plurality of second struts from one circumferential end positioned proximal to the distal end of the proximal portion; In the obstruction thrombus removal device comprising a,

The sleeve is self-expanding in a first state of opening the distal end of the self-expandable body according to the proximal movement of the attachment end for moving the other circumferential end of the surface of the sleeve toward the central axis in the longitudinal direction. Changing to a second state closing the distal end of the body possible

Obstruction thrombus removal device.
The method of claim 1,

The sleeve in the first state has a first diameter at the other circumferential end,

The sleeve in the second state has a second diameter at the other circumferential end, and the first diameter is larger than the second diameter

Obstruction thrombus removal device.
The method of claim 1,

In the first state, the attachment end is located distal to the one circumferential end, and the attachment end is located inside the self-expandable body,

In the second state, the attachment end is located proximal to the other circumferential end located proximal to the one circumferential end, and the attachment end and the other circumferential end are located inside the self-expandable body.

Obstruction thrombus removal device.
The method of claim 1, wherein the obstruction thrombus removal device

A pull wire connected to the self-expandable body through the attachment end and moving along a central axis in the longitudinal direction of the self-expandable body; further includes,

According to the proximal movement of the pull wire, the sleeve changes from the first state to the second state.

Obstruction thrombus removal device.
The method of claim 4, wherein the obstruction thrombus removal device

At least one stopper mounted on the pull wire and restricting the movement of the pull wire; further includes,

When the sleeve changes from the first state to the second state,

The distance between the at least one stopper and the proximal end of the self-expandable body decreases.

Obstruction thrombus removal device.
The method of claim 5,

In the second state, at least one stopper transmits a force to move the self-expandable body according to the proximal movement of the pull wire.

Obstruction thrombus removal device.
The method of claim 5,

In the second state, the pull wire transmits a force to the distal portion through the attachment end of the self-expandable body, and the pull wire applies a force to the proximal portion of the self-expandable body through at least one stopper. Conveying,

Obstruction thrombus removal device.
The method of claim 5,

The stopper includes a first stopper located distal to the proximal end of the self-expandable body and a second stopper located proximal to the proximal end of the self-expandable body

Obstruction thrombus removal device.
The method of claim 5, wherein the obstruction thrombus removal device

A tubular member slidably mounted on the pull wire and connected to the proximal end of the self-expandable body; further comprising,

In the second state, at least one stopper contacts the tubular member, and the self-expandable body moves proximally according to the proximal movement of the pull wire.

Obstruction thrombus removal device.
The method of claim 1,

A gap is formed between at least two struts disconnected from each other among the first struts of the self-expandable body

Obstruction thrombus removal device.
A self-expandable body having a plurality of struts;

A seal providing a tube surface having a proximal opening and a distal opening attached to the distal portion of the self-expandable body; And

Includes; a pull wire operatively coupled to the distal opening and configured to be slidable along the longitudinal direction of the self-expandable body,

When the pull wire is positioned in the first position, the thread allows the blood clot to enter the self-expandable body through a distal opening having a diameter similar to that of the proximal opening,

When the pull wire is located in a second position different from the first position, the thread closes the distal opening to prevent the blood clot from escaping from the self-expandable body.

Obstruction thrombus removal device.
The method of claim 11,

When the pull wire is positioned in the second position, the yarn is partially folded toward the pull wire.

Obstruction thrombus removal device.
The method of claim 11,

While the pull wire is located from the first position to the second position, the proximal portion of the self-expandable body does not substantially move.

Obstruction thrombus removal device.
The method of claim 11,

When the pull wire moves from the second position to a third position located opposite the first position, the self-expandable body moves integrally with the pull wire.

Obstruction thrombus removal device.
The method of claim 14,

While the pull wire moves from the second position to the third position, the thread maintains a folded shape.

Obstruction thrombus removal device.
The method of claim 14,

The first position, the second position, and the third position are in sequence from distal to proximal of the self-expandable body.

Obstruction thrombus removal device.
The method of claim 11,

At least one stopper mounted on the pull wire and restricting the movement of the pull wire; further comprising,

When the pull wire moves from the first position to the second position,

The distance between the at least one stopper and the proximal end of the self-expandable body decreases.

Obstruction thrombus removal device.
The method of claim 17,

While the pull wire moves from the second position to a third position located on the opposite side of the first position, the positional relationship between both ends of the pull wire and both ends of the self-expandable body by at least one stopper As it is fixed, the pull wire keeps the length of the self-expandable body constant.

Obstruction thrombus removal device.
The method of claim 11,

A gap is formed between at least two struts disconnected from each other among the struts of the self-expandable body

Obstruction thrombus removal device.
A pull wire provided to be slidably movable in a blood vessel in a longitudinal direction and having a protruding member formed at one point; A tubular member disposed on the pull wire so as to be relatively movable along the length direction with respect to the pull wire, and positioned proximal to the protruding member; A body including a plurality of struts whose one end is connected to the tubular member; And a sleeve provided on the distal end of the body and operatively coupled with the pull wire to open and close the distal end of the body according to the sliding movement of the wire; inserting the obstruction thrombus removal device into the catheter. Positioning the inside of the blood vessel in the state of being turned on;

The obstruction thrombus removal device is deployed as the obstruction thrombus removal device is released from the catheter.- The deployed obstruction thrombus removal device includes the protruding member being spaced apart from the tubular member and of the body. The fabric is deployed in an open state by the sleeve;

As the pull wire moves proximally to a point where the protruding member and the tubular member meet, the clogging thrombus removal device is deformed so that the distal end of the body is closed by the sleeve.- The pull wire and the protruding member While moving proximally to the point where the tubular member meets, the obturator thrombus removal device does not substantially move;

As the pull wire moves proximally from the point where the protruding member and the tubular member meet, the obstruction thrombus removal device moves proximally with the distal end of the body closed by the sleeve-the pull wire is the body By defining the lengths of both ends of the body is prevented from stretching along the longitudinal direction -; including

How to get rid of obstructive blood clots.