WO2020155081A1

WO2020155081A1 - Sealing sensor and sensing device

Info

Publication number: WO2020155081A1
Application number: PCT/CN2019/074363
Authority: WO
Inventors: 张笑宇; 于钱; 杨凯洪; 沈晓梅
Original assignee: 浙江凯立特医疗器械有限公司
Priority date: 2019-02-01
Filing date: 2019-02-01
Publication date: 2020-08-06

Abstract

A sealing sensor (100) and a sensing device. The sealing sensor (100) comprises a sensor frame (110), an electrode structure (120), sealing gaskets (130), and conduction members (140). The sealing gaskets (130) are at least partially filled in the sensor frame (110) so as to form an accommodation space (111) isolated from the external. The electrode structure (120) comprises a detection portion (121) and a circuit contact portion (122). The detection portion (121) is provided outside the accommodation space (111). The circuit contact portion (122) is provided in the accommodation space (111). The conduction members (140) are sealably penetrated in the sealing gaskets (130). One end of the conduction member (140) is electrically connected to the circuit contact portion (122), and the other end of the conduction member (140) is exposed outside the accommodation space (111). According to the sensor, the electrode structure can be isolated from the external environment to avoid the influence of the external environment on an electrode, ensure the stability of operation of the electrode, and prolong the service life thereof.

Description

Sealed sensor and sensing device

Technical field

The present invention relates to the technical field of biosensors, and more specifically, to a sensor sealing structure and a sensing device.

Background technique

Biosensors refer to devices that use physical and chemical detection methods to detect analytes containing biological components. They are the product of the interdisciplinary combination of modern biotechnology and microelectronics, optics, electromagnetics, and thermals. Currently, biosensors are mostly used in fields closely related to life sciences, such as medical inspection, food industry, bioengineering, agriculture, and animal husbandry. Since the 1960s, from the first use of enzyme-catalyzed processes and specificity of catalysis to form enzyme sensors with high sensitivity and strong selectivity, to later immunosensors, microbial sensors, and enzyme thermistor sensors, etc., Biosensors have been developed rapidly. So far, the development of biosensors has overcome the disadvantages of traditional biosensors, such as consuming reagents and destroying samples, and can be directly analyzed and used repeatedly, with simple operation. These characteristics have made important contributions to the development of basic medical research, clinical diagnosis and environmental medicine.

At present, in order to continuously monitor certain physiological data of the human body for a long time in clinical practice, a biosensor is fixedly placed on the subject for data collection. For example, the blood glucose sensor is used to continuously monitor the blood glucose change of the subject for a long time. Into the subject's subcutaneous tissue, the other part is fixed on the skin surface. This type of sensor needs to be fixed on the human body for a long time, so only with excellent waterproof and dustproof performance can the stability of the detection electrode be ensured and its service life can be extended as much as possible. Therefore, how to make the sensor structure have excellent sealing performance is an urgent problem for those skilled in the art to solve.

Summary of the invention

In view of this, the object of the present invention is to provide a sealed sensor that can seal and isolate the electrode structure from the external environment, prevent the influence of external environmental factors on the electrode, ensure the stability of the electrode work, and prolong the service life of the electrode.

Another object of the present invention is to provide a sensing device that not only has excellent sealing performance, but also can communicate with other terminals.

In order to achieve the above objective, the present invention provides the following technical solutions:

A sealed sensor, comprising a sensor frame, an electrode structure, a sealing gasket, and a conductive element; the sealing gasket is at least partially filled inside the sensor frame to form an accommodation space sealed to the outside; the electrode structure has a detection part And the circuit contact part, the detection part is arranged outside the accommodating space, the circuit contact part is arranged inside the accommodating space; the conductive member is sealed and penetrated in the sealing gasket, and one end of The circuit contact part is electrically connected, and the other end is exposed outside the accommodating space.

Further, the plane of the upper end surface of the sealing gasket is at the same height as the plane of the upper end of the conductive element.

Further, the sealing gasket is made of an elastic material, and the plane position of the upper end surface of the sealing gasket is higher than the plane of the upper end of the conducting member.

Further, the conductive member is an elastic conductive member that is compressible under an external force.

Further, the conductive member includes a fixed housing, two telescopic contacts, two springs and a partition, the partition is fixedly arranged inside the fixed housing, and the fixed housing The interior is divided into an upper chamber and a lower chamber. One end of the spring is connected to the upper and lower surfaces of the partition, one is located in the upper chamber and the other is located in the lower chamber; one end of the two telescopic contacts passes through the The openings of the fixed shell are respectively connected with springs, and the other end extends out of the fixed shell.

Further, when the conducting element is in a naturally extended state, the plane of the upper end surface of the sealing gasket is lower than the plane of the upper end of the conducting element, and the conducting element is in a compressed conducting state When the height of the plane of the upper end of the sealing gasket and the plane of the upper end of the conductive element is equal.

Further, the sealing gasket is made of an elastic material, the upper end surface of the sealing gasket is located on a plane equal to or higher than the plane of the upper end of the conducting member, and the conducting member is in a compressed and conductive state When the height of the plane of the upper end surface of the sealing gasket is equal to the plane of the upper end of the conductive element.

Further, the thickness of the contact part of the sealing gasket and the conductive element is greater than the thickness of other parts.

Further, a part of the upper surface of the sealing gasket protrudes to form a sealing column.

Further, the electrode structure includes a working electrode, a counter electrode, a blank electrode, and a reference electrode, and the electrodes are located on the same plane to form a flat structure or overlap to form a layered step structure.

A sensing device, including:

Like any of the aforementioned sealed sensors; and

A transmitter for transmitting the signal of the measured object obtained by the sealed sensor, and the sealed sensor is electrically connected to the transmitter through a conductive member.

Further, the transmitter includes an electrode contact point and a signal sending module, and the electrode contact point is electrically connected to the signal sending module.

Further, it also includes a skin base and a transmitter housing, the skin base is detachably connected to the transmitter housing; the signal transmission module is arranged inside the transmitter housing, and the electrode contact point is arranged at The transmitter housing is partially exposed to the outside, and the sealed sensor is arranged in a groove on the skin base.

The sealed sensor provided by the present invention includes a sensor frame, an electrode structure, a sealing gasket and a conductive element. The sealing gasket is at least partially filled inside the sensor frame, so as to form an accommodating space sealed and isolated from the outside with the sensor frame. The circuit contact part of the electrode structure is arranged inside the accommodating space, so that the circuit contact part is isolated from the external environment, which can effectively prevent dust, moisture or other substances from entering the accommodating space from affecting the circuit contact part, thereby ensuring The working stability of the electrode structure extends the service life of the electrode. The conductive element is sealed and penetrated in the sealing gasket, one end of which is electrically connected to the circuit contact part, and the other end is exposed to the outside of the accommodating space for connection with other functional modules, so as to connect the electrode The detected object data obtained by the structure is transmitted outwards.

The sensor device provided by the present invention includes the aforementioned sealed sensor and a transmitter electrically connected to the sealed sensor through a conductive member. The transmitter is used to send the measured object signal obtained by the sealed sensor to other terminals or receive control instructions sent by other terminals. In addition, the combination of the housing of the transmitter and the structure of the sealed sensor can further improve the overall sealing performance of the sensor device and ensure the stability of the work.

Description of the drawings

In order to explain the embodiments of the present invention or the technical solutions in the prior art more clearly, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only It is an embodiment of the present invention. For those of ordinary skill in the art, other drawings can be obtained according to the provided drawings without creative work.

Figure 1 is a schematic diagram of the structure of a sealed sensor in an embodiment of the present invention;

Figure 2 is a schematic diagram of a tiled electrode structure in an embodiment of the present invention;

Figure 3 is a schematic diagram of a stepped electrode structure in an embodiment of the present invention;

Fig. 4 is a schematic diagram of an accommodation space in an embodiment of the present invention;

Figure 5 is a schematic diagram of the thickness of the sealing gasket at different positions in an embodiment of the present invention;

6 is a schematic diagram of the positional relationship between the upper end surface of the sealing gasket and the upper end point of the conductive member in an embodiment of the present invention;

Figure 7 is a schematic diagram of a sealing column in an embodiment of the present invention;

Fig. 8 is a schematic structural diagram of a compressible conductive member in an embodiment of the present invention;

9 is a schematic diagram of the positional relationship between the upper end surface of the sealing gasket and the upper end point of the conductive element in an embodiment of the present invention;

Fig. 10 is a schematic structural diagram of a sensing device in an embodiment of the present invention.

Among them, the signs in the drawings are as follows:

100-seal sensor, 110-sensor frame, 111-accommodating space, 120-electrode structure, 121-detection part, 122-circuit contact part, 130-seal, 131-seal column, 140-conductor, 141- Fixed housing, 142- telescopic contact, 143- spring, 144- partition, 1411-upper chamber, 1412-lower chamber, 200-transmitter, 210-electrode contact point, 220-signal sending module, 230- Transmitter housing, 240-skin base.

detailed description

The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention.

Please refer to Figures 1 to 10. Figure 1 is a schematic diagram of a sealed sensor in an embodiment of the present invention; Figure 2 is a schematic diagram of a tiled electrode structure in an embodiment of the present invention; Figure 3 is a stepped type electrode structure in an embodiment of the present invention A schematic diagram of the electrode structure; Figure 4 is a schematic diagram of the accommodating space in an embodiment of the present invention; Figure 5 is a schematic diagram of the thickness of the gasket at different positions in an embodiment of the present invention; Figure 6 is the upper end surface of the gasket in an embodiment of the present invention and A schematic diagram of the plane positional relationship of the upper end points of the conducting element; FIG. 7 is a schematic diagram of the sealing column in an embodiment of the present invention; FIG. 8 is a schematic structural diagram of a compressible conducting element in an embodiment of the present invention; FIG. 9 is an implementation of the present invention In the example, a schematic diagram of the positional relationship between the upper end surface of the sealing gasket and the upper end point of the conductive element; FIG. 10 is a schematic structural diagram of a sensing device in an embodiment of the present invention.

As shown in FIG. 1, the present invention proposes a sealed sensor 100, which includes a sensor frame 110, an electrode structure 120, a sealing gasket 130 and a conductive member 140.

The gasket 130 is at least partially filled in the sensor frame 110 so as to form an accommodating space 111 sealed and isolated from the external environment by enclosing the sensor frame 110.

The electrode structure 120 has a detection portion 121 and a circuit contact portion 122. The detection part 121 is arranged outside the accommodating space 111 for detecting the signal of the test object. The detection method may be an existing method, and the detection part 121 may be located outside the skin for detection, such as detecting the signal of the test object in sweat. The detection unit 121 can also be implanted into the subcutaneous tissue structure for detection, such as implanting in the subcutaneous tissue to detect the signal of the test object in the tissue fluid or blood. The circuit contact portion 122 is disposed inside the accommodating space 111 for connection with the conductive member 140.

The conductive member 140 is sealed and penetrated in the sealing gasket 130, one end of which is electrically connected to the circuit contact portion 122, and the other end is exposed to the outside of the accommodating space 111. The conductive member 140 may be a conventional wire, one end of which is welded to the circuit contact portion 122 as a whole, and the other end is exposed outside the accommodating space 111 for connection with other circuits or modules. The conductive member 140 may also be an independent electrical conductive device, one end of which is electrically connected to the circuit contact portion 122 by contact, and the other end is exposed outside the accommodating space 111 for connecting with other circuits. Or module connection.

In order to increase the accuracy of electrode detection data, in the prior art, the chemical electrode structure generally includes two or more types of electrodes, such as a blank electrode, a reference electrode, etc. in addition to a working electrode and a counter electrode. The present invention does not specifically limit the number of electrode types in the electrode structure 120, and preferably two or more types.

In an embodiment of the present invention, as shown in FIG. 2, the electrode structure 120 includes four types of electrodes: a working electrode 1211, a counter electrode 1212, a blank electrode 1213 and a reference electrode 1214. The four kinds of electrodes are arranged in parallel in the same plane in sequence, the front part is the detection part 121, the back part is the circuit contact part 122, and the detection part 121 is electrically connected to the land through a wire.

In another embodiment of the present invention, as shown in FIG. 3, the electrode structure 120 includes four types of electrodes: a sheet-shaped working electrode 1211, a counter electrode 1212, a blank electrode 1213, and a reference electrode 1214. The four kinds of electrodes form a stepped structure in a superimposed manner, while reducing the volume, it also ensures that the detection portion 121 and the circuit contact portion 122 of each electrode can be exposed to the outside without blocking each other. Further, the detection part 121 of the electrode structure 120 may be made of a flexible material, which facilitates its implantation in the subcutaneous tissue.

The sealing gasket 130 may be partially filled inside the sensor frame 110, and another part may be exposed outside the sensor frame 110, or may be entirely located inside the sensor frame 110.

The size of the accommodating space 111 formed by the sealing gasket 130 and the sensor frame 110 sealed and isolated from the external environment can be determined by itself, provided that the space occupied by the circuit contact portion 122 of the electrode structure 120 is satisfied.

In an embodiment of the present invention, as shown in FIG. 4, in order to provide the best sealing effect as much as possible, except for the space occupied by the circuit contact portion 122, other spaces inside the sensor frame 110 are all sealed by a gasket 130. At this time, the accommodating space 111 is the space occupied by the circuit contact portion 122.

In another embodiment of the present invention, as shown in FIG. 1, under the premise of ensuring the sealing effect, in order to save the material used in the sealing gasket 130, the sealing gasket 130 is designed as a sealing sheet. At this time, the sheet and the sensor The space formed by the frame 110 is the accommodating space 111.

In another embodiment of the present invention, as shown in FIG. 5, since the conductive member 140 is penetrated in the sealing gasket 130, in order to ensure the sealing performance of the penetration position of the conductive member 140, the sealing gasket 130 The thickness of the position where the conductive member 140 is inserted is appropriately increased. At this time, the thickness of the position where the conductive member 140 is inserted is greater than the thickness of other positions.

Considering that the sealed sensor is sometimes detachably combined with a housing outside, in order to ensure the overall sealing performance after the housing and the sealed sensor are combined, it is necessary to set the plane of the upper end surface of the sealing gasket 130 and the conducting member 140 Adjust the positional relationship between the planes where the upper endpoint is located.

In an embodiment of the present invention, as shown in FIG. 6, the plane of the upper end surface of the sealing gasket 130 is at the same height as the plane of the upper end of the conductive member 140. At this time, when the housing cover is coupled to the upper side of the sealed sensor, the inner surface of the housing just makes sealing contact with the upper end surface of the sealing gasket 130 to play a sealing role, and the upper end of the conductive member 140 can also be connected to the housing The electrode contact point is turned on.

In another embodiment of the present invention, the gasket 130 is made of an elastic material, which can produce a certain compression deformation when pressed by an external force. The plane of the upper end surface of the sealing pad 130 may be slightly higher than the plane of the upper end of the conducting member 140. At this time, when the housing cover is coupled to the top of the sealed sensor, the electrode contact points on the housing are exactly at the same level. The upper end of the conducting member 140 is in contact and conduction, and the inner surface of the housing presses the sealing gasket 130, causing a certain compression deformation on the upper end surface thereof, so that the inner surface of the housing contacts the upper end surface of the sealing gasket 130 The position sealing effect is better, thereby further improving the overall sealing performance. As for how much higher the plane of the upper end surface of the gasket is than the plane of the upper end of the conductive element, it can be set according to the compression performance of the gasket. No matter how it is set, the final effect is the shell A compression seal is formed between the inner surface and the upper end surface of the gasket.

In another embodiment of the present invention, in consideration of saving materials for the sealing gasket 130, when the housing is covered and combined above the sealed sensor, the sealing gasket 130 and the housing are not in full contact, but partially in contact. As shown in FIG. 7, the upper surface of the sealing gasket 130 partially protrudes to form a sealing column 131, and the plane formed by the upper end of the sealing column 131 is the upper end surface of the sealing gasket 130. As mentioned above, the plane of the upper end surface of the sealing gasket 130 can be at the same height as the plane of the upper end of the conductive element 140. When the sealing pad 130 is made of elastic material and compressible, the plane of the upper end surface of the sealing pad 130 formed by the upper end of the sealing column 130 may be slightly higher than the plane of the upper end of the conducting member 140. On this basis, the lower surface of the sealing gasket 130 may partially protrude to form a supporting column, which supports the entire sealing gasket 130 to a certain extent.

In order to ensure sufficient contact between the conductive member 140 and the electrode contact points on other structures, the conductive member 140 is a longitudinally stretchable electrical conduction device, which is compressed when an external force is applied to it, and resumes when the external force is removed. The natural stretched state ensures close contact between the conductive member 140 and the external contact. As shown in FIG. 8, in an embodiment of the present invention, the conductive member 140 includes a fixed housing 141, two telescopic contacts 142, two springs 143 and a partition 144. The partition 144 is fixed inside the fixed housing 141, and divides the inside of the fixed housing 141 into an upper chamber 1411 and a lower chamber 1412. One ends of the two springs 143 are respectively connected to the two surfaces of the partition 144, one is located in the upper chamber 1411 and the other is located in the lower chamber 1412. One ends of the two telescopic contacts 142 are respectively connected to the spring 143 through the opening of the fixed housing 141, and the other end extends out of the fixed housing 141. When the electrode contact points on other structures are in contact with the telescopic contact 142, the spring 143 is squeezed, which will give a certain pressure to the telescopic contact 142, so that the telescopic contact 142 and the electrode contact point form closer contact, increasing The stability of electrical conduction. In addition, the partition 144 divides the inside of the fixed housing 141 into an upper chamber 1411 and a lower chamber 1412 that are isolated from each other, which can prevent foreign dust, moisture and other impurities from entering the accommodating space 111 through the conductive member 140. , Further increase the sealing performance of the sealed sensor 100.

As shown in FIG. 9, in an embodiment of the present invention, the conducting member 140 is compressible. When a housing is detachably combined with the outside of the sealed sensor 100, in order to ensure the integrity of the housing and the sealed sensor 100 after being combined Sealability. When the conducting element 140 is in a naturally extended state, the plane of the upper end surface of the gasket 130 is lower than the plane of the upper end of the conducting element 140, and the conducting element 140 is In the compressed conduction state, the plane of the upper end surface of the sealing gasket 130 and the plane of the upper end of the conducting member 140 are at the same height, that is, in the same plane, to achieve an overall sealing effect.

Further, the sealing gasket 130 is made of elastic material. Under the condition of being compressible, when the conducting member 140 is in a natural extended state, the upper end surface of the sealing gasket 130 is at a plane position equal to or slightly higher than When the upper end of the conductive member 140 is located on a plane, and the conductive member 140 is in a compressed and conductive state, the upper end surface of the gasket 130 is located on the plane and the upper end of the conductive member 140 is located The plane heights are equal, and at this time, a compression seal is formed between the inner surface of the housing and the upper end surface of the gasket 130, which further improves the overall sealing effect.

As shown in FIG. 10, the present invention proposes a sensing device, which includes the sealed sensor 100 in the foregoing embodiment and a transmitter 200 for transmitting the signal of the measured object obtained by the sealed sensor 100. The sealed sensor 100 It is electrically connected to the transmitter 200 through the conductive member 140.

In an embodiment of the present invention, the transmitter 200 includes an electrode contact point 210 and a signal sending module 220. The electrode contact point 210 is electrically connected to the signal sending module 220. The connection method may be an existing technology, such as Connect by wire. The conductive member 140 is in contact with the electrode contact point 210 to realize the electrical conduction connection between the sealed sensor 100 and the transmitter 200, so that the measured object data acquired by the electrode structure 120 of the sealed sensor 100 can be transmitted to The signal sending module 220 and the signal sending module 220 then transmit the data to other terminals to facilitate operations such as analysis and viewing. Of course, the signal sending module 220 can also receive instructions sent by other terminals to control the data collection work of the sealed sensor 100, such as when to start the collection, when to end the collection, and the collection time interval.

On the basis of the previous embodiment, the transmitter 200 further includes a transmitter housing 230 and a skin base 240, the signal transmission module 220 is provided inside the transmitter housing 230, and the electrode contact point 210 is provided On the housing of the transmitter housing 230 and partially exposed to the outside. A groove is provided on the skin base 240, and the sensor frame 110 of the sealed sensor 100 is arranged in the groove. The connection between the transmitter housing 230 and the skin base 240 may be a threaded connection, or an existing connection such as a snap connection. The skin base 240 can be fixed on the skin surface. On the one hand, it is used to fix the sealed sensor 100, and on the other hand, it forms a protective cover for the sealed sensor 100 together with the transmitter housing 230, which can effectively isolate external dust and moisture. Such impurities can avoid the influence of external environmental factors on the sealed sensor 100, thereby increasing the working stability of the sealed sensor 100 and extending the service life.

The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be obvious to those skilled in the art, and the general principles defined in this document can be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown in this text, but should conform to the widest scope consistent with the principles and novel features disclosed in this text.

Claims

A sealed sensor, which is characterized in that it comprises a sensor frame, an electrode structure, a sealing gasket, and a conductive element; the sealing gasket is at least partially filled inside the sensor frame to form a housing space sealed from the outside; the electrode The structure has a detection part and a circuit contact part, the detection part is arranged outside the accommodating space, the circuit contact part is arranged inside the accommodating space; the conductive member is sealed and penetrated in the sealing gasket One end is electrically connected to the circuit contact part, and the other end is exposed outside the accommodating space.
The sealed sensor according to claim 1, wherein the height of the upper end surface of the sealing gasket is equal to the height of the upper end of the conductive element.
The sealed sensor according to claim 1, wherein the sealing gasket is made of elastic material, and the upper end surface of the sealing gasket is located at a higher plane than the upper end of the conductive member.
The sealed sensor according to claim 1, wherein the conductive member is a compressible elastic conductive member.
The sealed sensor according to claim 4, wherein the conductive member includes a fixed housing, two telescopic contacts, two springs and a partition, and the partition is fixed on the fixed housing. The inside of the body divides the inside of the fixed housing into an upper chamber and a lower chamber. One end of the spring is connected to the upper and lower surfaces of the partition, one is located in the upper chamber and the other is located in the lower chamber. One ends of the two telescopic contacts are respectively connected to the springs through the openings of the fixed shell, and the other ends extend out of the fixed shell.
The sealed sensor according to claim 4, wherein when the conductive member is in a naturally extended state, the plane of the upper end surface of the sealing gasket is lower than the plane of the upper end of the conductive member, And when the conductive element is in a compressed conduction state, the plane of the upper end of the sealing gasket is at the same height as the plane of the upper end of the conductive element.
The sealed sensor according to claim 4, wherein the sealing gasket is made of elastic material, and the plane of the upper end surface of the sealing gasket is equal to or higher than the plane of the upper end of the conductive member, And when the conductive element is in a compressed conduction state, the plane of the upper end surface of the sealing gasket is at the same height as the plane of the upper end of the conductive element.
The sealed sensor according to any one of claims 1 to 7, wherein the thickness of the contact part of the gasket and the conductive member is greater than the thickness of other parts.
7. The sealed sensor according to any one of claims 1 to 7, wherein a part of the upper surface of the sealing gasket protrudes to form a sealing column.
The sealed sensor according to any one of claims 1 to 7, wherein the electrode structure includes a working electrode, a counter electrode, a blank electrode, and a reference electrode, and the electrodes are located on the same plane to form a flat structure or Stacked to form a layered step structure.
A sensing device, characterized in that it comprises:

The sealed sensor as claimed in any one of claims 1 to 10; and

A transmitter for transmitting the signal of the measured object obtained by the sealed sensor, and the sealed sensor is electrically connected to the transmitter through a conductive member.
The sensing device according to claim 11, wherein the transmitter comprises an electrode contact point and a signal sending module, and the electrode contact point is electrically connected to the signal sending module.
The sensor device according to claim 12, further comprising a skin base and a transmitter housing, the skin base is detachably connected to the transmitter housing; the signal transmission module is provided in the transmitter housing In the interior of the device housing, the electrode contact points are arranged on the transmitter housing and partly exposed to the outside, and the sealed sensor is arranged in a groove on the skin base.