WO2020140338A1 - Huile essentielle ayant un composé antalgique, son procédé de préparation et son application - Google Patents

Huile essentielle ayant un composé antalgique, son procédé de préparation et son application Download PDF

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Publication number
WO2020140338A1
WO2020140338A1 PCT/CN2019/080155 CN2019080155W WO2020140338A1 WO 2020140338 A1 WO2020140338 A1 WO 2020140338A1 CN 2019080155 W CN2019080155 W CN 2019080155W WO 2020140338 A1 WO2020140338 A1 WO 2020140338A1
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WO
WIPO (PCT)
Prior art keywords
oil
parts
compound essential
borneol
pain relief
Prior art date
Application number
PCT/CN2019/080155
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English (en)
Chinese (zh)
Inventor
詹若挺
严萍
曾唯雅
卢晓莹
宋晓娟
林翠清
Original Assignee
广州中医药大学(广州中医药研究院)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 广州中医药大学(广州中医药研究院) filed Critical 广州中医药大学(广州中医药研究院)
Publication of WO2020140338A1 publication Critical patent/WO2020140338A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Definitions

  • the invention relates to a massage oil, which belongs to the technical field of daily-use health chemicals, and in particular relates to a compound essential oil for pain relief, and a preparation method and application thereof.
  • Massage massage is a kind of physical therapy and natural therapy. It is safe and effective. It is widely used. It can relieve symptoms and discomfort, promote health and improve the quality of life. It is very popular among the general public. The use of functional massage oil can play a role in strengthening the targeted and improve the therapeutic effect.
  • Essential oils are volatile aromatic substances extracted from the flowers, leaves, stems, roots or fruits of plants by steam distillation, extrusion, cold soaking or solvent extraction. Essential oils contain many different ingredients, some of which can be composed of more than 250 different molecules. Essential oils are lipophilic and easily soluble in oils, because the molecular chains of essential oils are usually relatively short, which makes them very easy to penetrate the skin and enter the body through the rich capillaries under the subcutaneous fat.
  • Chinese herbal medicine essential oils have unique effects.
  • the reasonable combination of Chinese herbal medicine essential oils with different functions can be prepared into Chinese herbal medicine compound essential oils to achieve complementary effects, complement each other and complement each other.
  • the purpose of the present invention is to provide a fast and efficient pain-relieving compound essential oil.
  • Another object of the present invention is to provide a preparation method and application of the above-mentioned rapid and efficient pain relief compound essential oil.
  • the present invention is implemented using the following technical solutions.
  • a compound essential oil for pain relief is formulated, which is composed of olive oil or base oil, borneol, clove oil, and peppermint oil; the base oil One or more selected from sweet almond oil, wheat germ oil, jojoba oil, evening primrose oil, grape seed oil and the like.
  • the raw materials include a combination of base oil, borneol, clove oil, and peppermint oil.
  • the dosage ratio of a kind of pain relief compound essential oil raw material is:
  • the specific ratio of raw materials includes:
  • the raw material dosage ratio of a compound oil for pain relief is:
  • the specific ratio of raw materials includes:
  • base oil 60 to 80 parts of base oil, 3 to 40 parts of borneol, 2 to 35 parts of clove oil and peppermint oil.
  • the raw material dosage ratio of a compound oil for pain relief is:
  • Per 1000mL of compound essential oil for pain relief contains the ratio of borneol, clove oil, peppermint oil and olive oil is (1-2): (94-97); furthermore, 97 parts of olive oil, borneol, clove oil And 1 mint oil each.
  • the specific ratio of raw materials includes:
  • Per 1000mL of compound essential oil for pain relief contains borneol, peppermint oil, clove oil 1 and the ratio of base oil is (1-2): (94-97); preferably, 97 parts of base oil, borneol, 1 serving each of clove oil and mint oil.
  • a preparation process of pain-relieving compound essential oil Under a suitable temperature (25°C), take a clean container, put olive oil and borneol raw materials first, gently stir to mix well, then add clove oil and mint oil raw materials , Stir thoroughly until fully mixed.
  • a method of using compound essential oils for pain relief Before use, clean the skin of uncomfortable parts or meridians, acupuncture points, tendons and veins or massage areas, apply an appropriate amount of this product, usually by a professional physician or masseur. It can be operated by myself or others, using fingers or palms for massage, massage or pressing, etc. The strength, amplitude and duration are properly controlled according to individual and specific circumstances.
  • a pain-relieving compound essential oil product used as a meridian, acupuncture point, skin massage, massage or local application, has the effect of relaxing muscles and muscles, relieving pain, suitable for neck, shoulder, back and back pain, extremity joint pain, stomach, abdomen , Head and other pains, mosquito bites and itching embolism.
  • the ingredients of the present invention are all natural products, without the addition of preservatives, artificial fragrances and hormones, the appearance is golden yellow, no suspension, no precipitation, there is an elegant fragrance of Chinese herbal plant essential oil, the skin feels cool, and there is no irritation to the skin.
  • the present invention adopts a compound essential oil prepared from a combination of borneol, clove oil, peppermint oil, and olive oil to alleviate body pain caused by various reasons, has a rapid onset of effect, and has a significant effect.
  • the present invention uses borneol scent to be elegant and elegant, through all kinds of tricks, to disperse scorching fire, tonic muscles and analgesic, clove oil fragrance is rich and gentle, to remove bad odor, eliminate swelling, bacteriostatic and anti-inflammatory.
  • Skin, brain refreshing, antibacterial cleansing, soothing veins; refreshing and cool with mint oil, soothing body and mind; and olive oil as a base oil has good skin-friendly, the four combined, complement each other, complement each other, a total of It has the effect of relieving pain in body parts caused by various reasons.
  • a pain-relieving compound essential oil of the present invention Before use, clean the skin of the uncomfortable parts or the meridian, acupuncture point, tendon and vein massage or massage parts, apply this product in an appropriate amount, and apply it by a professional physician or masseur. I or other people operate, massage, massage or press with fingers or palms, the strength, amplitude and duration are properly controlled according to individual and specific circumstances.
  • Natural borneol is made from the fresh branches and leaves of the camphor tree Cinnnmomumcamphora (L.) Presl by extraction and processing, or artificially synthesized borneol (C 10 H 18 O).
  • Indications Used for fever, coma, convulsions, stroke phlegm, Qi depression, convulsions, coma, chest pain, heartache, red eyes, mouth sores, sore throat, pus in the ear canal.
  • Source Made from the extraction and processing of the dried flower buds of Myrtleaceae lilac Eugenia caryophllata Thunb.
  • Source Made from the extraction and processing of the dried aerial parts of the mint plant Mentha haplocalyx Briq.
  • Indications Used for wind-heat colds, wind temperature at the beginning, headache, red eyes, throat paralysis, aphthous ulcers, rubella, measles, chest flank swelling.
  • Source Made from the refined stone fruits of olive oil.
  • base oil for massage oil essential oil formula, cooking, etc.
  • Base oil eg sweet almond oil, wheat germ oil, jojoba oil, evening primrose oil, grape seed oil, etc.
  • grape seed oil or wheat germ oil is selected.
  • Grape seed oil the seeds of grapes are extracted by high temperature squeezing method, rich in vitamins, minerals, protein, etc.; light and dry texture, low irritation, good moisturizing effect, strong skin affinity, easy to be absorbed by the skin; Cleansing effect, suitable for all kinds of skin. If you use it during the day, wipe off the excess oil or wash it with water to prevent the oil from staying on the skin. It is easy to cause pigmentation due to ultraviolet rays in the sun.
  • Wheat germ oil It is extracted by high temperature pressing on small hair germ, which is rich in vitamin E, B, protein, empty substance and so on. It can regulate endocrine, lose weight, prevent stains, dark spots and pigmentation; anti-oxidation, reduce the formation of lipid peroxide, delay aging, etc.
  • the efficacy of the compound essential oil for pain relief is not a simple superposition of the above-mentioned traditional Chinese medicine and olive oil, but a reasonable combination of various medicines, highlighting the complex oil and muscle relaxation of this compound essential oil, Efficacy characteristics and therapeutic advantages of pain relief.
  • Olive oil in the examples fresh olive fruit, using pure physical low-temperature pressing method, produced by Guangzhou Xuanyi Flavor & Fragrance Co., Ltd.
  • clove oil lac tree stems and leaves are extracted by steam distillation, Guangzhou Xuanyi Flavor & Fragrance Co., Ltd. Production
  • peppermint oil extracted by steam distillation on stems and leaves, produced by Guangzhou Xuanyi Flavor & Fragrance Co., Ltd.
  • borneol sinthesized, produced by Hebei Anguo Ruiqi Chinese Medicinal Materials Co., Ltd.
  • Each 1000g of compound essential oil for pain relief contains 10g of borneol, clove oil and peppermint oil, and 970g of olive oil.
  • the preparation method of the compound essential oil is as follows:
  • Each 1000g of compound essential oil for pain relief contains 10g of borneol and mint oil, 20g of clove oil, and 950g of grape seed oil.
  • the preparation method of the compound essential oil is as follows:
  • Each 1000g of compound essential oil for pain relief contains 30g of borneol, 40g of clove oil, 30g of peppermint oil, and 900g of base oil (a mixture of wheat germ oil and grape seed oil).
  • the preparation method of the compound essential oil is as follows:
  • Each 1000g of compound essential oil for pain relief contains 30g of borneol, 43g of clove oil, 30g of peppermint oil, and 897g of base oil (a mixture of wheat germ oil and olive oil).
  • the preparation method of the compound essential oil is as follows:
  • Each 1000g of compound essential oil for pain relief contains 10g of borneol, 10g of clove oil, 10g of peppermint oil, and 970g of olive oil.
  • the preparation method of the compound essential oil is as follows:
  • Each 1000g of compound essential oil for pain relief contains 20g of borneol, 20g of clove oil, 20g of peppermint oil, and 940g of olive oil.
  • the preparation method of the compound essential oil is as follows:
  • a suitable temperature 25°C
  • take a clean container put olive oil and borneol raw materials first, and gently stir until they are evenly mixed. Then add the clove oil and mint oil raw materials, and stir thoroughly until they are evenly mixed.
  • Each 1000g of compound essential oil for pain relief contains 20g of borneol, 30g of clove oil, 10g of peppermint oil, and 940g of olive oil.
  • the preparation method of the compound essential oil is as follows:
  • Each 1000g of compound essential oil for pain relief contains 20g of borneol, 30g of clove oil, 10g of peppermint oil, and 940g of olive oil.
  • the preparation method of the compound essential oil is as follows:
  • Each 1000g of compound essential oil for pain relief contains 20g of borneol, 30g of clove oil, 10g of peppermint oil, and 940g of olive oil.
  • the preparation method of the compound essential oil is as follows:
  • Each 1000g of compound essential oil for pain relief contains 20g of borneol, 30g of clove oil, 10g of peppermint oil, and 940g of olive oil.
  • the preparation method of the compound essential oil is as follows:
  • Each 1000g of compound essential oil for pain relief contains 100g of peppermint oil and 900g of olive oil.
  • the preparation method of the compound essential oil is as follows:
  • Each 1000g compound oil used for pain relief contains 50g clove oil, 50g mint oil, and 900g olive oil.
  • the preparation method of the compound essential oil is as follows:
  • Test method 100 male volunteers were divided into 10 groups, and massage was performed for 10 days using the compound massage essential oils prepared in Examples 1-5 and Comparative Examples 1-2 and commercially available products, respectively. It is rated for its comfort ( ⁇ 30), fatigue elimination ( ⁇ 30), and pain relief ( ⁇ 40).
  • the present invention adopts compound essential oil prepared from a combination of borneol, clove oil, peppermint oil, olive oil or other base oils to alleviate pain in body parts caused by various reasons, has a quick onset of effect, and has remarkable effects.
  • the combination of Chinese herbal medicines should follow the compatibility and synergism between the drugs.
  • the compatibility should be simple and not complicated.
  • the inventor conducted a large number of combination tests, carefully selected, and finally selected a combination of borneol, clove oil, peppermint oil, olive oil or other base oils, and the combination of four extracts achieved a single Targeting and synergistic effect, it is very good for alleviating body pain caused by various reasons.
  • the traditional Chinese medicine composition can achieve the best effect, the compatible dosage of the single traditional Chinese medicine and the dosage of the composition are also critical.
  • the composition limit in the present invention is based on the compatibility and mutual synergy of traditional Chinese medicine, and the reasonable and optimal dosage and dosage determination effect obtained through a large number of experiments, and the dosage of the composition is also creative to a certain extent.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne une huile essentielle ayant un composé antalgique et un procédé de fabrication associé. L'huile essentielle ayant un composé antalgique est préparée à partir des matières premières suivantes en parties en poids : 50 à 97 parties d'huile d'olive ou d'une autre huile de base, 1,5 à 35 parties de bornéol, 1,0 à 30 parties d'huile de girofle et 0,5 à 20 parties d'huile de menthe poivrée. L'huile essentielle est appropriée pour éliminer la douleur du cou, de l'épaule, de la taille et du dos, la douleur des articulations des quatre membres, la douleur de l'estomac, de l'abdomen et de la tête, la douleur due aux démangeaisons des piqûres de moustiques, et analogues.
PCT/CN2019/080155 2019-01-03 2019-03-28 Huile essentielle ayant un composé antalgique, son procédé de préparation et son application WO2020140338A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910005254.5A CN109432174A (zh) 2019-01-03 2019-01-03 一种缓解疼痛复方精油及其制备方法与应用
CN201910005254.5 2019-01-03

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Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109432174A (zh) * 2019-01-03 2019-03-08 广州中医药大学(广州中医药研究院) 一种缓解疼痛复方精油及其制备方法与应用
CN114984116B (zh) * 2022-06-02 2024-03-26 广州白云山维一实业股份有限公司 具有舒缓疼痛功效的精油组合物及其应用
CN115708794A (zh) * 2023-01-09 2023-02-24 同芙集团(中国)股份有限公司 一种抑菌精华油

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1579431A (zh) * 2003-08-12 2005-02-16 崔名全 清凉霜
CN103316084A (zh) * 2013-05-20 2013-09-25 钟小强 缓解腰痛的复方精油
CN109432174A (zh) * 2019-01-03 2019-03-08 广州中医药大学(广州中医药研究院) 一种缓解疼痛复方精油及其制备方法与应用

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Publication number Priority date Publication date Assignee Title
US5223257A (en) * 1992-03-11 1993-06-29 Vasu Arora Topical composition for relieving aches and pains

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1579431A (zh) * 2003-08-12 2005-02-16 崔名全 清凉霜
CN103316084A (zh) * 2013-05-20 2013-09-25 钟小强 缓解腰痛的复方精油
CN109432174A (zh) * 2019-01-03 2019-03-08 广州中医药大学(广州中医药研究院) 一种缓解疼痛复方精油及其制备方法与应用

Non-Patent Citations (1)

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Title
SUN, LING-FENG: "The Bioactivities of Plant Essential Oil and the Terpenoids in It", JOURNAL OF JIANGX NORMAL UNIVERSITY, vol. 24, no. 2, 31 May 2000 (2000-05-31), pages 159 - 163, XP055716390, ISSN: 1000-5862, DOI: 10.16357/jcnki.issn.1000-5862.2000.02.016 *

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