WO2020138923A1

WO2020138923A1 - Uterine tissue collection instrument

Info

Publication number: WO2020138923A1
Application number: PCT/KR2019/018410
Authority: WO
Inventors: 정민호; 김지현
Original assignee: 주식회사 엔도비전; 정민호; 김지현
Priority date: 2018-12-24
Filing date: 2019-12-24
Publication date: 2020-07-02

Abstract

The present invention relates to a uterine tissue collection instrument. The uterine tissue collection instrument, which collects uterine cell tissue when inserted into the uterine cervix, comprises: a manipulation rod extending in the length direction and provided with a handle at the rear end portion thereof; and a collection brush having a rod-shaped core portion which is fixed to the front end portion of the manipulation rod and provides support, a roll brush portion which is installed on a partial region of the core portion and comes into contact with the uterine cervix, and an inclined brush portion which is installed between the ends of the roll brush portion and the manipulation rod and which, when the roll brush portion comes into contact with the uterine cervix, simultaneously comes into contact with the inlet portion.

Description

Uterine tissue collection tool

The present invention relates to a tissue harvesting tool used for intrauterine tissue examination, and more particularly, to a uterine tissue harvesting tool capable of effectively collecting tissue cells with little pain of a patient.

Among various diseases occurring in the female genital organs, as a disease related to the uterus, uterine myoma, adenomyosis, endometriosis, endometrial cancer, and cervical cancer are known. Of these, cervical cancer is a cancer that occurs in the cervix, which is the entrance to the uterus. It begins with epithelial dysplasia and develops into invasive cervical cancer through cervical epithelial cancer if not treated in time. In addition, endometrial cancer is a disease in which abnormal cancer cells grow because endometrial cells that cover the inner space of the uterus cause genetic variation.

Meanwhile, for accurate diagnosis of diseases related to the uterus, a sample for microscopic examination is required, and a brush is often used as a means for securing the sample. For example, in a medical examination institution such as a hospital or a public health center, a sample is collected by rubbing the test site of the uterus with a soft brush.

The brush is composed of an elongated handle portion to be inserted into the womb and a sample collection portion located at the end of the handle portion. The handle part is a rod-shaped member made of flexible synthetic resin, and the sample collection part is made of a support wire made by twisting a wire, and a thin brush that is fixed by being inserted into the support wire.

However, the above-mentioned conventional brush has a drawback that the sample collection part simply extends in a straight line, and thus the contact area of the sample collection part with respect to the inspection part is narrow, so that sampling is not smooth. For example, when the sample for cervical cancer examination is sampled, the end portion of the sample collection portion is erected with respect to the surface of the entrance portion of the cervix, and therefore, the entrance portion must be used several times. Needless to say, the carelessness of the harvester can leave a scar on surrounding tissue including the cervix.

In addition, in the case of the endometrium, since the endometrium spreads from side to side through the cervix, it is not easy to bring the rod-shaped sample collection unit close to the endometrium itself. In order to access the sample collection section to the endometrium, the handle must be tilted or turned back and forth, which extends the time of sample collection, and the patient feels pain as the patient.

In addition, in some cases, a curette is used for tissue collection, but there is a burden of local anesthesia because the curette involves pain when used.

The present invention was created to solve the above problems, and it is possible to quickly collect samples, as well as to quickly collect samples for the entrance portion of the uterus and the passage portion inside the cervix at the same time. It is an object of the present invention to provide a useful uterine tissue collection tool when a large amount of a sample is required because it can be efficiently performed and the sample can be taken out by a suction method.

The uterine tissue collection tool of the present invention as a solution for solving the problem for achieving the above object is to be inserted into the cervix, to collect the cellular tissue of the entrance and cervix of the cervix and extend in the longitudinal direction. An operation rod having a handle at the rear end; It is fixed to the distal end of the operation rod and provides a rod-shaped core portion that provides support, and is installed between a portion of the core portion and a roll brush portion contacting the cervical canal portion, between the roll brush portion and the end of the operation rod, and the roll brush portion is cervical A collection brush having an inclined brush portion which is in contact with the inlet portion at the same time when it comes into contact with the tube portion is included.

In addition, as a cylindrical member for receiving and protecting the collecting brush therein in a state supported by the operation rod, a protective cap for moving the handle to expose the collecting brush is further provided for use of the collecting brush.

In addition, the operation rod, a locking projection is formed to prevent the separation of the protective cap, the protective cap is in the form of a cylinder with one end open, and the other end is provided with a locking jaw supported by the locking projection do.

In addition, the operation rod is provided with a notch-shaped cutting portion that is concentrated and cut when the user applies a bending force, and a marking portion is formed on the side of the cutting portion to guide the position of the cutting portion.

In addition, the uterine tissue harvesting tool of the present invention as a solution to the problem for achieving the above object is to reach the inside of the uterine body constituting the uterus, to collect the cell tissue of the endometrium, extending in the longitudinal direction thereof An operation rod having a handle at the rear end; A harvesting brush fixed to the distal end of the operation rod and provided with a rod-shaped deep portion providing support force and a roll brush portion fixed to the deep portion to obtain cell tissue of the endometrium; It includes an outer tube that simultaneously covers a part of the collection brush and the operation rod.

In addition, the end of the operation rod is further provided with a shape memory deformation portion that is deformed after the collection brush is inserted into the uterine body portion to bring the collection brush closer to the uterine wall.

In addition, an insertion protrusion is formed on the inner circumferential surface of the outer tube, and the operation rod accommodates the insertion protrusion of the retracted outer tube to prevent the movement of the outer tube and guide the position of the holding groove. The marking portion is formed.

In addition, the uterine tissue collection tool of the present invention as a solution to the problem for achieving the above object is extended, extending in the longitudinal direction, the hollow rod is formed with at least one side hole open to the side; A sealing cap sealing the leading end of the hollow rod; A collection brush supported by the sealing cap and acquiring cell tissue of a region of interest inside the uterus; It is inserted into the hollow rod and includes an operation handle that is pulled by the user to form a negative pressure in the hollow rod, so that the tissue around the side hole is sucked into the hollow rod.

In addition, the operation handle has a suction bar with its rear end extending out of the hollow rod while being inserted into the hollow rod, and a handle fixed to the rear end of the suction rod.

In addition, a piston that is in contact with the inner circumferential surface of the hollow rod is mounted at the tip of the suction bar.

In addition, the piston is made of rubber or synthetic resin having elasticity, and the outer circumferential surface is in close contact with the inner circumferential surface of the hollow rod to form a negative pressure inside the hollow rod when it moves to the rear of the hollow rod by the suction bar.

In addition, a collection housing groove is formed in the piston for accommodating the suction sucked into the hollow rod through the side hole by the negative pressure formed when the piston is retracted.

In addition, the collecting brush; It is composed of a rod-shaped core portion providing a supporting force and a brush portion fixed to the core portion, and the brush portion is inclined forward so as to have an acute angle between the core portions.

In addition, a safety lapping unit is provided at the distal end of the core to prevent damage to the intrauterine tissue by the core.

And, the hollow rod is made of a translucent synthetic resin, and the suction bar is equipped with an O-ring of a color that can be visually confirmed from the outside of the hollow rod.

The uterine tissue collection tool of the present invention made as described above has a large contact area with respect to the surface to be sampled, enabling efficient and rapid sample collection, as well as samples for the entrance of the uterus and the passageway inside the cervix. As it can be quickly collected, it is convenient to use.

In addition, since the movement of the brush portion that has entered the internal space of the uterus is possible, the proximity of the brush portion to the endometrium is easy, and thus the sampling of the endometrial portion can be efficiently performed.

In addition, it is useful when a large amount of sample is needed, as the sample may be taken out by a suction method by applying a negative pressure that is lower than atmospheric pressure, if necessary.

1 is a partial cross-sectional view for explaining the configuration of a uterine tissue collection tool according to a first embodiment of the present invention.

FIG. 2 is a view showing a method of using the collecting tool shown in FIG. 1.

3 is a partial cross-sectional view showing another example of a utensil tissue collecting tool according to the first embodiment of the present invention.

4 and 5 are views for explaining a method of using the utensil tissue collection tool shown in FIG.

6 is a side view showing another example of a utensil tissue collecting tool according to the first embodiment of the present invention.

FIG. 7 is a view for explaining an example of using the utensil tissue collecting tool shown in FIG. 6.

8 is a perspective view showing a collection brush that can be applied to the uterine tissue collection tool according to the first and second embodiments of the present invention.

9 is a cross-sectional view showing the configuration of a uterine tissue collecting tool according to a second embodiment of the present invention.

10A and 10B are cross-sectional views showing a part of the hollow rod applicable to the uterine tissue harvesting tool shown in FIG. 9.

11 is a partial cross-sectional view showing another example of a uterine tissue collection tool according to a second embodiment of the present invention.

12 is an exploded cross-sectional view showing a part of the operation handle shown in FIG. 11.

13 is a view showing another example of a uterine tissue collecting tool according to the second embodiment of the present invention.

14 is a view showing another example of a uterine tissue collecting tool according to a second embodiment of the present invention.

15 is a side view showing a modified example of the sealing cap shown in FIG. 11.

Hereinafter, one embodiment according to the present invention will be described in more detail with reference to the accompanying drawings.

1 is a partial cross-sectional view for explaining the configuration of the uterine tissue collection tool 20 according to the first embodiment of the present invention, and FIG. 2 is a view showing a method of using the collection tool shown in FIG. 1.

Uterine tissue collection tool 20 according to the first embodiment has a feature capable of simultaneously collecting tissue cells of the cervical duct 12a and the inlet 12b of the uterus 10.

The basic configuration of the collection tool 20 is to insert the cervical tissue into the cervix and insert the cervical tissue into the cervix, extending in the longitudinal direction and having a handle at the rear end. Wow; It is fixed to the distal end of the operation rod and provides a rod-shaped core portion that provides support, and is installed between a portion of the core portion and a roll brush portion contacting the cervical canal portion, between the roll brush portion and the end of the operation rod, and the roll brush portion is cervical It is made of a collecting brush having an inclined brush portion which is in contact with the inlet portion at the same time when it comes into contact with the tube portion.

The operation rod 21 is made of a flexible material and consists of a rod body 21b and a handle 21a extending in the longitudinal direction. The size of the rod body 21b may vary depending on the case, and the shape of the handle 21a may be variously designed in consideration of ergonomic convenience.

A locking protrusion 21d is formed on the outer circumferential surface of the distal end of the rod body 21b. The locking protrusion 21d is a portion protruding in the radial direction, and the locking cap 23b of the protective cap 23 to be thickened is prevented from falling off.

In addition, a cutting portion 21c and a marking portion 21e are provided at the rear side of the engaging projection portion 21d. The cutting portion 21c is a notched groove formed convexly, so that the rod body 21b can be easily cut. For example, when a user applies a bending force, stress is concentrated and cut.

The reason for cutting the rod body 21b is to seal the specimen, that is, the collecting brush 25 in which the cell tissue is buried in the whole liquid. In other words, the cutting portion 21c is broken and placed in a bottle containing a chemical solution for inspection.

The marking portion 21e is a display portion for guiding the position of the cutting portion 21c. For example, it functions to allow the user to know the location of the cutting part 21c immediately. Since the rod body 21b is thin and the cut portion 21c is not easily seen, the marking portion 21e can be applied to be used more conveniently. The shape or position of the marking portion can be variously changed.

Particularly, as shown in FIG. 2, the collection brush 25 has a structure capable of simultaneously collecting cell tissue from the cervical canal 12a and the inlet 12b. It is composed of a rod-shaped core portion 25a, a roll brush portion 25b, and an inclined brush portion 25c.

The core portion 25a is a rod-like member fixed to the front end portion of the rod body 21b of the operation rod 21, and serves to support the roll brush portion 25b and the inclined brush portion 25c. The core portion 25a may be formed by twisting stainless steel wire or may be formed of synthetic resin. The synthetic resin core is made at the same time when the rod body 21b is molded.

The roll brush portion 25b occupies approximately half of the longitudinal direction of the core portion 25a and extends in the radial direction of the core portion 25a. It looks like a brush for eyebrow makeup. Roll brush portion (25b) is inserted into the cervical portion (12a) of the cervix (12) in the state of the cervical portion (12a) by sweeping the inner wall surface to collect the cell tissue.

In addition, the inclined brush portion 25c has a form inclined forward while being fixed to the core portion 25a. For example, it is inclined to have an angle between 40 and 50 degrees with respect to the core portion 25a. Each hair constituting the inclined brush portion 25c is longer than the roll brush portion 25b.

In addition, the inclined brush portion 25c waits in a pressed state by the protective cap 23 as shown in FIG. 1 and spreads when the protective cap 23 is removed, taking the form of FIG. 2.

The protective cap 23 is a cylindrical member opened to the front (opposite to the direction in which the handle is located) and receives and protects the collecting brush 25 therein. A locking jaw 23b is formed on the inner circumferential surface of the rear end of the protective cap 23. The locking jaw 23b is a protrusion that is caught by the locking protrusion 21d, and prevents the protective cap 23 from moving forward. The protective cap 23 is movable backward, that is, in the direction of the arrow a.

The method of using the collecting tool 20 having the above configuration is as follows.

First, the front end of the collection tool 20 in a state where the protective cap 23 is covered is reached in front of the cervix 12, and then the protective cap 23 is moved backward. As the protective cap 23 retracts, the collecting brush 25 and the inclined brush portion 25c, which have been accommodated therein, are exposed.

In this state, the roll brush portion 25b is inserted into the cervix portion 12a. As the roll brush portion 25b is inserted into the cervical canal portion 12a, the inclined brush portion 25c automatically comes into contact with the inlet portion 12b. If the roll brush portion 25b is in contact with the cervical canal portion 12a and the inclined brush portion 25c is in contact with the inlet portion 12b, grab the handle 21a and arrow the rod body 21b. It moves in the g direction or vice versa and up and down directions.

According to the axial rotation of the rod body 21b, the roll brush part 25b collects the cell tissue in the cervical canal part 12a, and the inclined brush part 25c acquires the cell tissue of the inlet part 12b.

When the above process is completed, the roll brush part 25b is pulled out of the cervical canal 12a and the protective cap 23 that has been retracted is advanced again, so that the collecting brush 25 is completely accommodated inside the protective cap 23. Afterwards, the extraction tool 20 is removed from the womb. The protective cap 23 serves to prevent the collection brush 25 having cell tissue from contacting the inner wall of the vagina. If the collected cells are cancer cells, the cancer may be metastasized by the harvested cells, so the collection brush 25 must be wrapped with a protective cap 23. However, in some cases, the protective cap 23 may not be advanced again, and the collecting brush 25 may be removed as it is.

3 is a partial cross-sectional view showing another example of the uterine tissue collecting tool 20 according to the first embodiment of the present invention, and FIGS. 4 and 5 illustrate a method of using the uterine tissue collecting tool illustrated in FIG. 3 It is a drawing for.

Hereinafter, the same reference numerals as those described above denote the same members having the same function.

Uterine tissue harvesting apparatus according to another example, to reach the interior of the uterine body constituting the uterus to collect the cell tissue of the endometrium, extending in the longitudinal direction and having an operation rod having a handle at the rear end; A harvesting brush fixed to the distal end of the operation rod and provided with a rod-shaped deep portion providing support force and a roll brush portion fixed to the deep portion to obtain cell tissue of the endometrium; It has a basic structure including an outer tube that simultaneously covers a part of the collection brush and the operation rod.

3 to 5, for example, the harvesting tool 20 is inserted into the uterine body portion 16 to collect the cellular tissue of the endometrium 14.

The collecting tool 20 having such a purpose is composed of an operation rod 21, a collecting brush 25, and an outer tube 27.

The operation rod 21 is composed of a rod body 21b, which is a synthetic resin member extending in the longitudinal direction, and a handle 21a at the rear end of the rod body 21b. The rod body 21b has a flexible property and has a holding groove 21f and a marking portion 21e on its outer circumferential surface.

The holding groove 21f extends in the circumferential direction of the rod body 21b to receive and support the insertion projections 27a formed on the outer tube 27 as constricted portions where both ends meet, thereby restraining the movement of the outer tube 27 do. The marking unit 21e is a display unit that informs the position of the holding groove 21f.

Of course, the shape of the holding groove 21f may be variously changed in consideration of convenience of use or productivity of the product. For example, a plurality of holding grooves may be applied, but the holding grooves may be arranged at regular intervals, or the shape of the holding grooves itself may be applied, such as a sheath. Of course, the holding groove itself can be omitted.

A collecting brush 25 is mounted on the leading end of the rod body 21b. The collecting brush 25 is composed of a rod-shaped core portion 25a and a roll brush portion 25b. As shown in Fig. 5, the collecting brush 25 serves to collect tissue cells of the endometrium 14 by moving from side to side while inserted into the uterine body 16.

The outer tube 27 is a hollow pipe-shaped member that simultaneously receives a portion of the collecting brush 25 and the rod body 21b of the operation rod therein. An insertion protrusion 27a is formed on the inner circumferential surface of the rear end of the outer tube 27. The insertion protrusion 27a is fitted into the holding groove 21f in a state where the outer tube 27 is retracted toward the handle 21a. In particular, the outer tube 27 has a flexible property that can be bent by external force.

In order to use the collecting tool 20, first, as shown in FIG. 4, the collecting brush 25 covered by the outer tube 27 is placed in the uterine body portion 16 through the cervical tube portion 12a. Reach. Subsequently, the outer tube 27 is retracted in the direction of the arrow b so that the insertion protrusion 27a is fitted into the holding groove 21f. When the outer tube 27 is retracted, as shown in FIG. 5, the collecting brush 25 is exposed to the outside. In this state, the handle 21a is moved from side to side, so that the roll brush portion 25b collects the cell tissue of the endometrium 14.

If the collecting operation is completed, the outer tube 27 is advanced again to accommodate the collecting brush 25 inside the outer tube 27, and then the collecting tool 20 is removed from the uterus. In some cases, the collecting brush 25 may be removed without moving the outer tube 27 again.

6 is a side view showing another example of a uterine tissue harvesting tool according to a first embodiment of the present invention, and FIG. 7 is a view for explaining an example of using the uterine tissue harvesting tool shown in FIG. 6.

Referring to the drawings, it can be seen that the shape memory deformation portion 29 is applied between the collecting brush 25 and the rod body 21b. The shape memory deformation portion 29 is a rod-shaped member made of a shape memory alloy, and connects the core portion 25a and the rod body 21b. The shape memory deformation part 29 maintains a straight line at normal temperature and has a property of bending in an atmosphere of body temperature. For example, it is bent sideways in the range of 34°C to 40°C.

Therefore, by moving the outer tube 27 forward, the collecting brush 25 and the shape memory deformed portion 29 are wrapped, and the collecting brush 25 is placed in the uterine body portion 25, and then the outer tube 27 ) When retracted, the collecting brush 25 is bent sideways by the action of the shape memory deformed portion 29 to automatically come into contact with the endometrium 14. It is possible for the user to collect the tissue of the endometrium 14 even if the user does not move the operation rod 21 from side to side but only rotates the shaft on the spot.

In addition, as described above, since the outer tube 27 has a flexible property, even if the shape memory deformation portion 29 is bent, the outer tube 27 can be moved forward to accommodate the collecting brush 25. have. That is, after the collection of the cell tissue through the collecting brush 25 is completed, the outer tube 27 is advanced to be taken out of the uterus while surrounding the collecting brush 25.

After taking out the collecting cart 20 from the uterus, the collecting brush 25 is put in the liquid phase and shaken to separate the collected cell tissue and seal the liquid.

8 is a perspective view of another type of harvesting brush 25 that can be applied to a uterine tissue harvesting tool according to the present invention.

The collecting brush 25 shown in FIG. 8 is composed of a rod-shaped core portion 25a and a screw brush portion 25d. The screw brush portion 25d has a shape in which a plurality of hairs parallel to each other are twisted at a predetermined angle while going in the longitudinal direction of the core portion 25a.

9 is a cross-sectional view showing the configuration of the uterine tissue harvesting tool 40 according to the second embodiment of the present invention, FIGS. 10A and 10B are hollow rods 41 applicable to the uterine tissue harvesting tool shown in FIG. 9 ) Is a sectional view showing a part.

Uterine tissue retrieval tool 40 according to the second embodiment has a collection brush 25 as a basic configuration, and in addition, additionally has a suction function capable of aspirating a specimen. The suction function, for example, creates a negative pressure environment, such as a syringe, and serves to extract the cell tissue of a region of interest. Thus, since the acquisition of the sample is performed in a dual manner, the acquisition rate of the sample can be increased by increasing the number of acquisitions that can be collected at one time.

As will be described later, the uterine tissue collection mechanism of the second embodiment uses the suction function to suck the cancer cells present in the lumen in a state away from the intrauterine tumor, scratch the intrauterine cavity using a collection brush, or malignant cells in the tumor mass It has the dual effect of increasing the tissue collection rate by dropping.

The harvesting tool 40 includes a hollow rod extending in the longitudinal direction and having at least one side hole open to the side; A sealing cap sealing the leading end of the hollow rod; A collection brush supported by the sealing cap and acquiring cell tissue of a region of interest inside the uterus; It has a basic structure that is inserted into the hollow rod and pulled by the user to form a negative pressure in the hollow rod so that the tissue around the side hole is sucked into the hollow rod.

The hollow rod 41 is open at both ends and has at least one side hole 41b as a hollow pipe type member having a certain inner diameter. The hollow rod 41 has flexible properties and can be molded and manufactured from various types of synthetic resins.

The side hole 41b is a hole having a certain inner diameter or a hole having a long hole shape, and when negative pressure is formed in the straight passage 41a inside the hollow rod 41, the outer cell tissue is moved into the straight passage 41a. It is an induction passage. The position of the side hole (41b) is designed to be fitted in the cervical canal (12a), with the collection brush (25) inserted into the uterine body (16). As long as the design condition can be satisfied, the number of the side holes 41b, the detailed location, and the size can be changed.

In addition, a locking protrusion 41c is formed on the outer circumferential surface of the front end of the hollow rod 41. The locking protrusion 41c serves to support the locking jaw 23b of the protective cap 23 to prevent the protective cap 23 from coming off. The locking protrusion 41c is the same as the locking jaw 23b described with reference to FIG. 1. The protective cap 23 serves to receive and protect the collecting brush 25 in a state fitted to the distal end of the hollow rod 41.

The front end of the hollow rod 41 is closed with a sealing cap 45. The sealing cap 45 serves to seal the end portion of the hollow rod 41 and to support the collecting brush 25. The sealing cap 45 can be made of synthetic resin or stainless steel.

In addition, a collecting brush holder 45a is provided at the center of the collecting brush 25. The collecting brush holder 45a fixes the core portion 25a detachably.

The piston 43c is provided inside the hollow rod 41. The piston 43c is a member made of synthetic resin or rubber and has an O-ring groove 43e on its outer circumferential surface. Naturally, the O-ring 43d is fitted in the O-ring groove 43e. O-ring (43d) serves to seal between the inner circumferential surface of the hollow rod 41 and the piston (43c).

The piston 43c is located between the sealing cap 45 and the side hole 41b. The reason why the piston 43c is positioned in front of the side hole 41b is to obtain a stronger initial suction power. When the piston 43c starts to move backward by pulling the handle 43b, which will be described later, the negative pressure starts to be formed in the straight passage 41a, and the formed negative pressure acts as the piston 43c meets the side hole 41b. Bring the sample inside. After that, even if the piston 43c is further retracted, it goes without saying that the extraction of the sample continues.

In addition, on the surface facing the collecting brush holder 45a in the piston 43c, a concave shape collecting housing 43f is formed. The collection receiving groove 43f is a groove that can contain the collected cell tissue therein. After obtaining the collected object, when the collecting tool 40 is placed vertically, the sample inside the straight passage 41a flows into and collects in the collecting housing 43f.

The suction bar 43a is fixed to the piston 43c so that the piston 43c can be pulled back. The suction bar 43a is a rod-shaped member extending rearward in a state coupled to the piston 43c and has a handle 43b at its rear end. When the suction bar 43a is pulled by grasping the handle 43b, the piston 43c moves rearward and forms a negative pressure in the straight passage 41a to absorb surrounding tissue.

The method of using the collecting tool 40 having the above configuration is as follows. First, while the protective cap 23 surrounds the collecting brush 25, the collecting tool 40 is inserted into the inside of the uterus. If the collecting brush 25 is located in the uterine body portion 16, the protective cap 23 is retracted toward the handle 43b. At this time, the protective cap 23 should not cover the side hole 41b.

When the collecting brush 25 is exposed by retracting the protective cap 23, the hollow rod 41 is moved left and right to cause the collecting brush 25 to collect the cellular tissue of the endometrium 14. In addition, with this, the suction bar (43a) is pulled backward to aspirate the cell tissue inside the cervical canal (12a). The aspirated cell tissue is collected inside the straight passage (41a).

When the above process is completed, the protective cap 23 is moved forward to return to the original position, and the retrieval tool 40 is removed from the uterus and then a subsequent process is performed. If necessary, the collecting brush 25 may be removed without moving the protective cap 23 forward.

11 is a partial cross-sectional view showing another example of a uterine tissue collecting tool according to the second embodiment of the present invention, and FIG. 12 is an exploded cross-sectional view showing a part of the operation handle shown in FIG. 11.

The collecting tool 40 shown in FIGS. 11 and 12 is a type in which the above-described piston (43c in FIG. 9) is omitted. Instead of the piston 43c being omitted, the outer circumferential surface of the suction bar 43a is almost in contact with the inner circumferential surface of the hollow rod 41, and the suction bar 43a is filled with an O-ring 43d. The O-ring (43d) acts to create a negative pressure in the vacuum rod (41) when the suction bar (43a) is taken out from the hollow rod (41). The handle 43b has a concave central portion in consideration of ergonomic convenience.

In addition, the hollow rod 41 is made of a translucent synthetic resin and the O-ring 43d may have a color that can be visually identified from the outside of the hollow rod 41. For example, the hollow rod 41 is molded into a white series translucent, and the O-ring 43d is red or blue or has a different color. Thus, by making the O-ring 43d visible from the outside of the hollow rod 41, it is possible to easily grasp the position of the suction bar 43a inside the hollow rod 41.

On the other hand, the other end of the hollow rod 41 is filled with a sealing cap 52 of another form. The basic function of the sealing cap 52 is to seal the tip of the hollow rod 41, as described above. The sealing cap 52 can be made of stainless steel or synthetic resin.

The sealing cap 52 has a structure of an insertion portion 52a, a fixed tooth portion 52b, and a cover portion 52d. The insertion portion 52a is a cylindrical portion having a certain diameter, and is a portion that is driven into the tip portion of the hollow rod 41 by a press-fit method. In addition, the fixed tooth portion 52b is a triangular serrated projection integrally formed on the outer circumferential surface of the insertion portion 52a, and prevents the sealing cap 52 embedded in the hollow rod 41 from falling out. Since the hollow rod 41 is made of synthetic resin, the inner circumferential surface of the hollow rod 41 is fixed to the fixed toothed portion 52b, so to speak, so that the escape of the sealing cap 52 is prevented.

The cover portion 52d covers the front end surface of the hollow rod 41. Of course, the maximum diameter of the cover portion 52d is the same as the outer diameter of the hollow rod 41. By applying the cover portion 52d as described above, the edge portion of the tip of the hollow rod 41 is not exposed, so that the internal tissue is not damaged when entering the uterus.

On the other hand, the collecting brush 53, the core portion formed by twisting the wire (53a), the inclined brush portion (53c) supported by the core portion (53a), and a safety lapping portion covering the tip of the core portion (53a) ( 53b). The inclined brush portion 53c is obtained by sweeping the intrauterine tissue, and takes a form inclined forward to have an acute angle between the deep portions 53a. Said angle may be approximately 40 to 50 degrees.

In addition, the safety wrapping portion 53b is a portion formed of polyurethane, and wraps the tip of the core portion 53a. Since the core portion 53a is manufactured by twisting a metal wire, it is possible to injure the endometrium when entering the uterus, thus applying the safety lapping portion 53b to prevent the induction of the wound.

13 is a view showing another example of the uterine tissue collecting tool 40 according to the second embodiment of the present invention.

Referring to the drawing, it can be seen that the fixed scale 41d is displayed on the outer circumferential surface of the hollow rod 41. At this time, the hollow rod 41 has translucent translucency. Since the fixed scale 41d is formed on the translucent hollow rod 41, it is possible to easily grasp the position or the moving distance of the suction bar 43a fitted inside the hollow rod 41.

14 is a view showing another example of the uterine tissue collecting tool 40 according to the second embodiment of the present invention.

A moving scale 43f is formed on the suction bar 43a of the collecting tool 40 shown in FIG. 14, and a stopper portion 43g is provided between the suction bar 43a and the handle 43b. The moving scale 43f starts from the stopper portion 43g. That is, the starting point (0 point) of the scale is located at the connection portion between the suction bar 43a and the stopper portion 43g.

The stopper portion 43a contacts the rear end portion 41e of the hollow rod 41 in a state where the suction bar 43a is completely inserted into the hollow rod 41. Therefore, when the suction bar 43a completely inserted into the hollow rod 41 starts to be pulled out to the rear, the movement scale 43f starts to appear, and the movement distance of the suction bar 43a is moved through the movement scale 43f. Able to know.

15 is a side view showing a modification of the sealing cap 52 shown in FIG. 11.

The sealing cap 52 shown in FIG. 15 is formed with a fixing screw portion 52c that takes the form of a male screw. The sealing cap 52 at the end of the hollow rod 41 can be fixed by being spirally driven.

As described above, the present invention has been described in detail through specific embodiments, but the present invention is not limited to the above embodiments, and various modifications can be made by those skilled in the art within the scope of the technical spirit of the present invention.

Claims

As it is inserted into the cervix, the cell tissue of the entrance and cervix of the cervix is collected,

An operation rod extending in the longitudinal direction and having a handle at its rear end;

It is fixed to the distal end of the operation rod and provides a rod-shaped core, which is mounted on a partial area of the core and is in contact with the cervical canal, is installed between the roll brush and the end of the operation rod, and the roll brush is hysteroscope A uterine tissue collection tool including a collecting brush having an inclined brush portion that simultaneously touches the inlet portion when it comes into contact with the tube.
According to claim 1,

A uterine tissue collecting tool further comprising a protective cap that receives and protects the collecting brush therein while being supported by the operation rod, and moves to the handle side to expose the collecting brush for use of the collecting brush.
According to claim 2,

On the operation rod, a locking protrusion for preventing the protection cap from being detached is formed,

The protective cap is a uterine tissue collection tool having a cylindrical shape with one end open and a locking jaw supported by the locking protrusion at the other end.
The method of claim 2 or 3,

The operation rod is provided with a notch-shaped cutting portion that is cut by focusing stress when the user applies a bending force, and on the side of the cutting portion, a uterine tissue collection tool is formed with a marking portion to guide the location of the cutting portion.
As for reaching the inside of the uterine body constituting the uterus and collecting the cell tissue of the endometrium,

An operation rod extending in the longitudinal direction and having a handle at its rear end;

A harvesting brush fixed to the distal end of the operation rod and provided with a rod-shaped deep portion providing support force and a roll brush portion fixed to the deep portion to obtain cell tissue of the endometrium;

Uterine tissue collection tool comprising an outer tube to simultaneously cover a portion of the collection brush and the operation rod.
The method of claim 5,

At the end of the operation rod, a collection brush is inserted into the uterine body, and then is deformed, and a shape memory deformation unit for bringing the collection brush closer to the uterine wall is further provided.
The method of claim 5 or 6,

Insertion projections are formed on the inner circumferential surface of the outer tube,

In the operation rod, a uterine tissue collecting tool is formed with a holding groove for receiving the insertion protrusion of the retracted outer tube to prevent movement of the outer tube and a marking portion for guiding the position of the holding groove.
A hollow rod extending in the longitudinal direction and having at least one side hole open to the side;

A sealing cap sealing the leading end of the hollow rod;

A collection brush supported by the sealing cap and acquiring cell tissue of a region of interest inside the uterus;

Uterine tissue collection tool, which is inserted into the hollow rod and is pulled by the user to form a negative pressure within the hollow rod, thereby operating the tissue around the side hole to be sucked into the hollow rod.
The method of claim 8,

The operation handle,

A suction bar with its rear end extended out of the hollow rod while being inserted into the hollow rod,

Uterine tissue collection tool having a handle fixed to the rear end of the suction bar.
The method of claim 9,

A uterine tissue collection tool equipped with a piston in contact with the inner circumferential surface of the hollow rod at the distal end of the suction bar.
The method of claim 10,

The piston is made of rubber or synthetic resin having elasticity, and the outer circumferential surface is in close contact with the inner circumferential surface of the hollow rod to move the rear of the hollow rod by the suction bar to form a negative pressure inside the hollow rod.
The method of claim 11,

In the piston, a uterine tissue collection tool having a collection housing groove for accommodating the suction sucked into the hollow rod through the side hole by the negative pressure formed when the piston is retracted.
The method of claim 8,

The collecting brush;

It is composed of a rod-shaped core portion providing a supporting force and a brush portion fixed to the core portion,

The brush portion is a uterine tissue collecting tool inclined forward so as to have an acute angle between the deep portions in the longitudinal direction.
The method of claim 13,

Uterine tissue collection tool provided with a safety lapping portion to prevent damage to the intrauterine tissue by the deep portion by wrapping the tip portion at the distal end of the core portion.
The method of claim 9,

The hollow rod is made of a translucent synthetic resin,

The suction bar, a uterine tissue collection tool equipped with a collar O-ring that can be visually confirmed from the outside of the hollow rod.