WO2020110222A1

WO2020110222A1 - Concentration measurement device, concentration measurement method, and non-transitory storage medium

Info

Publication number: WO2020110222A1
Application number: PCT/JP2018/043732
Authority: WO
Inventors: 石原　康利
Original assignee: 学校法人明治大学
Priority date: 2018-11-28
Filing date: 2018-11-28
Publication date: 2020-06-04
Also published as: JPWO2020110222A1; JP7197205B2

Abstract

One embodiment of the present invention is a concentration measurement device comprising a first emission unit for emitting light having a first wavelength, a second emission unit for emitting light having a second wavelength, a first acquisition unit for acquiring a physical quantity caused by a change in an object of measurement when light having the first wavelength and light having a first intensity and the second wavelength are emitted onto the object of measurement, a second acquisition unit for acquiring a physical quantity caused by a change in the object of measurement when light having the first wavelength and light having a second intensity different from the first intensity and the second wavelength are emitted onto the object of measurement, a temperature information acquisition unit for using the acquired physical quantities to acquire information about variation in the temperature of the object of measurement, and a concentration acquisition unit for using the information about the variation in temperature and the acquired physical quantities to acquire the non-target-component concentration of the object of measurement.

Description

Density measuring device, density measuring method and non-transitory recording medium

The present invention relates to a concentration measuring device, a concentration measuring method, and a non-transitory recording medium.

The number of diabetic patients has increased explosively in recent years, and it is predicted that the number of diabetic patients will reach 550 million worldwide in 2030 (see Non-Patent Document 1). The basic treatment for diabetes is diet/exercise based on blood glucose level control, and it is necessary to measure the blood glucose level several times a day for the blood glucose level control. Although a general blood glucose meter requires blood sampling, it has problems with pain, hygiene, and medical waste. Therefore, the establishment of a non-invasive and non-invasive blood glucose level measuring device is eagerly desired.

In response to such demands, methods for measuring blood glucose levels from information on light transmission/reflection/scattering have been vigorously studied (see Patent Documents 1 to 4 and Non-Patent Document 2). However, these methods have a problem that it is difficult to accurately estimate the blood glucose level because the transmitted light intensity is insufficient with respect to the measurement accuracy (about ±10 milligrams/deciliter) required for managing the blood glucose level.

On the other hand, a blood glucose level measuring method using a photoacoustic effect in which light energy absorbed by a substance is converted into a heat wave and an elastic wave has been studied (see Patent Documents 5 to 6). These methods have a feature that a detection signal is larger than a method using transmitted light and that the measurement region can be specified in the depth direction by controlling the modulation frequency of the excitation light (see Non-Patent Document 3). ).

However, when the above-mentioned method is used, there is a problem that noise due to a signal derived from water, which is a non-target component, is mixed in the measurement result, and the reliability and accuracy of the measured blood glucose level are significantly reduced. This is because the spectral spectrum of glucose and the spectral spectrum of water contained in the living body to be measured overlap each other.

That is, when the glucose concentration is measured using only the energy obtained with light of a certain wavelength, there is a problem that it cannot be distinguished whether the energy is derived from glucose or water. Furthermore, there is a possibility that the glucose concentration may be erroneously measured even if the amount of water contained in the living body is slightly changed due to various factors.

As one method to solve this problem, a method of measuring the spectral spectrum detected from the target object at a plurality of wavelengths and using multivariate analysis or a neural network to estimate the concentration of the substance contained in the measurement target is known. (See Non-Patent Document 4).

JP, 10-325794, A JP, 11-216131, A Japanese Patent Laid-Open No. 2004-147706 JP, 2005-37253, A JP, 2008-191160, A JP, 2009-165634, A

However, as in the method described in Non-Patent Document 4 described above, when measuring a spectral spectrum at a plurality of wavelengths, it is necessary to arrange a light source and a detection device for a plurality of wavelengths, which complicates the device and makes measurement. There is a problem that it takes time. In particular, the amount of glucose in the living body is very small, and high measurement accuracy is required at all wavelengths for measuring the spectrum. Therefore, when the method described in Non-Patent Document 4 is used, the problems of complication of the device and lengthening of the measurement become prominent.

Therefore, in order to solve these problems, an object of the present invention is to provide a technique capable of measuring the concentration of a target component contained in a measurement target using a simple device.

One embodiment of the present invention includes a first irradiation unit that irradiates a measurement target having a target component and a non-target component with light having a first wavelength, and light having a second wavelength that is a wavelength different from the first wavelength. A second irradiation unit that irradiates the measurement target with the first irradiation unit irradiates the measurement target with light having the first wavelength, and the second irradiation unit first emits light having the second wavelength. When irradiating the measurement target with intensity, a first acquisition unit that acquires a physical quantity resulting from a change in the measurement target, and the first irradiation unit irradiates the measurement target with light of the first wavelength, The 2nd acquisition which acquires the physical quantity resulting from the change of the above-mentioned measuring object, when the above-mentioned 2nd irradiation part irradiates the above-mentioned measuring object with the 2nd intensity different from the 1st above-mentioned light of the 2nd wavelength. Unit, a temperature information acquisition unit that acquires temperature information that is information related to a temperature change of the measurement target based on the physical quantity acquired by the first acquisition unit and the physical quantity acquired by the second acquisition unit, and the temperature information. And a concentration acquisition unit that acquires the concentration of the non-target component based on the physical quantity acquired by the first acquisition unit and the physical quantity acquired by the second acquisition unit.

One aspect of the present invention is the above-described concentration measuring device, wherein the concentration acquisition unit acquires the concentration by multivariate analysis.

One mode of the present invention is the above-mentioned concentration measuring device, wherein the concentration acquisition unit is a learning model learned in advance, and the physical quantity acquired by the first acquisition unit and the second acquisition unit are acquired. The concentration is acquired based on a learning model representing the relationship among the physical quantity, the temperature information, and the concentration.

One aspect of the present invention is the above-described concentration measuring device, wherein the second wavelength is a wavelength at which the absorbance of the target component is smaller than that of the non-target component.

One aspect of the present invention is the above-described concentration measuring device, wherein the second wavelength is a wavelength that changes the absorption spectrum of the non-target component to a predetermined magnitude or more.

One aspect of the present invention is the above-described concentration measuring device, wherein the second wavelength is a wavelength at which the absorbance of the non-target component is maximum.

One aspect of the present invention is the above-described concentration measuring device, wherein the second wavelength is within a range of ±70 nanometers centered on the wavelength at which the absorbance of the non-target component is maximum.

One aspect of the present invention is the above-described concentration measuring device, wherein the first wavelength is within a range of ±70 nanometers centered on the wavelength at which the absorbance of the target component is maximum.

One aspect of the present invention is the above-described concentration measuring device, wherein the first wavelength is a wavelength at which the absorbance of the target component is maximum.

One mode of the present invention is the above-mentioned concentration measuring device, showing the influence of the environment on the physical quantity based on the physical quantity acquired by the first acquisition section and the physical quantity acquired by the second acquisition section. A correction unit that acquires a correction coefficient that is a value and corrects the physical quantity acquired by the first acquisition unit and the physical quantity acquired by the second acquisition unit by the acquired correction coefficient is further included.

One aspect of the present invention is the above-mentioned concentration measuring device, wherein the influence of the environment is the amount of the non-target component.

One mode of the present invention is the above-mentioned concentration measuring device, wherein the influence of the environment is the absorbance of the non-target component with respect to the first wavelength and the absorbance of the non-target component with respect to the second wavelength. ..

One aspect of the present invention is the above-described concentration measuring device, wherein the influence of the environment is the performance of the light receiving unit that receives the light of the first wavelength.

One aspect of the present invention is the above-mentioned concentration measuring device, wherein at least one of the light of the first wavelength and the light of the second wavelength is coded light.

One embodiment of the present invention is the above-described concentration measuring device, comprising an n-th irradiation unit (n is an integer of 3 or more) that irradiates a measurement target having a target component and a non-target component with light having an n-th wavelength. Further prepare.

One aspect of the present invention is the above-described concentration measuring device, wherein the second wavelength and the third wavelength are wavelengths having a predetermined correlation with respect to the shift of the absorption spectrum of the non-target component.

One embodiment of the present invention is the above-described concentration measuring apparatus, wherein the second wavelength and the third wavelength have opposite signs with respect to the origin of the wavelength of the peak of the absorption spectrum of the non-target component. It is the wavelength located at the position.

One embodiment of the present invention is the above-described concentration measuring apparatus, wherein the second wavelength and the third wavelength have opposite signs with respect to the wavelength of the inflection point of the absorption spectrum of the non-target component as the origin. Is a wavelength located at a position.

One aspect of the present invention is the above-mentioned concentration measuring device, wherein the physical quantity is intensity of transmitted light, scattered light, or reflected light of the light with which the measurement target is irradiated.

One aspect of the present invention is the above-described concentration measuring device, wherein the physical quantity is the intensity of transmitted light with which the measurement target is irradiated.

One aspect of the present invention is the above-described concentration measuring device, wherein the physical quantity is an amplitude of a vibration wave generated in the measurement target by the light with which the measurement target is irradiated.

One aspect of the present invention is the above-described concentration measuring device, wherein the vibration wave is an amplitude of a heat wave generated in the measurement target by the light with which the measurement target is irradiated.

One aspect of the present invention is the above-described concentration measuring device, wherein the vibration wave is an amplitude of a sound wave due to a heat wave generated in the measurement target by the light with which the measurement target is irradiated.

One embodiment of the present invention is the above-described concentration measuring device, wherein a piezoelectric body that generates a voltage proportional to the magnitude of the pressure when pressure is applied, and a tension member that applies tension to the piezoelectric body A holder that is in close contact with the measurement target is provided, and the first acquisition unit and the second acquisition unit acquire the physical quantity based on the voltage generated by the piezoelectric body.

One aspect of the present invention is the above-described concentration measuring device, wherein the temperature information is a shift amount of the absorption spectrum of the non-target component.

One embodiment of the present invention includes a first irradiation unit that irradiates a measurement target having a target component and a non-target component with light having a first wavelength, and light having a second wavelength that is a wavelength different from the first wavelength. A second irradiation unit that irradiates the measurement target with the first irradiation unit irradiates the measurement target with light having the first wavelength, and the second irradiation unit first emits light having the second wavelength. When irradiating the measurement target with intensity, a first acquisition unit that acquires a physical quantity resulting from a change in the measurement target, and the first irradiation unit irradiates the measurement target with light of the first wavelength, The 2nd acquisition which acquires the physical quantity resulting from the change of the above-mentioned measuring object, when the above-mentioned 2nd irradiation part irradiates the above-mentioned measuring object with the 2nd intensity different from the 1st above-mentioned light of the 2nd wavelength. Unit, a temperature information acquisition unit that acquires temperature information that is information related to a temperature change of the measurement target based on the physical quantity acquired by the first acquisition unit and the physical quantity acquired by the second acquisition unit, and the temperature information. And a concentration acquisition unit that acquires the concentration of the non-target component based on the physical quantity acquired by the first acquisition unit and the physical quantity acquired by the second acquisition unit. There, a first irradiation step of irradiating the measurement target with light of the first wavelength, a second irradiation step of irradiating the measurement target with light of the second wavelength, and the first irradiation unit A physical quantity resulting from a change in the measurement target when the measurement target is irradiated with light of a first wavelength and the second irradiation unit irradiates the measurement target with light of the second wavelength at a first intensity. A first acquisition step of acquiring, and the first irradiation unit irradiates the measurement target with light having the first wavelength, and the second irradiation unit sets light having the second wavelength as the first intensity. When the measurement target is irradiated with different second intensities, a second acquisition step of acquiring a physical quantity due to a change of the measurement target, a physical quantity acquired by the first acquisition unit, and the second acquisition unit A temperature information acquisition step of acquiring temperature information that is information related to the temperature change of the measurement target based on the physical quantity that has been measured, the temperature information, the physical quantity acquired by the first acquisition unit, and the physical quantity acquired by the second acquisition unit. And a concentration acquisition step of acquiring the concentration of the non-target component based on the following.

One aspect of the present invention is a non-transitory recording medium that stores a program for causing a computer to function as the concentration measuring device according to claim 1.

According to the present invention, it becomes possible to measure the concentration of the target component contained in the measurement target using a simple device.

It is a figure showing an example of functional composition of concentration measuring device 1 of a 1st embodiment. It is a figure which shows the relationship between the absorption spectrum of the target component of the light of the 1st wavelength in the 1st Embodiment, and the light of the 2nd wavelength, and the absorption spectrum of a non-target component. It is a figure showing an example of functional composition of information processor 100 in a 1st embodiment. 5 is a flowchart showing an example of a flow of processing in which the information processing unit 100 according to the first embodiment acquires a glucose concentration. It is a 1st figure which shows the simulation result which shows the dependence with respect to the intensity|strength of the 2nd wavelength of the absorption spectrum of the biological body 9 in 1st Embodiment. It is a 2nd figure which shows the simulation result which shows the dependence with respect to the intensity|strength of the 2nd wavelength of the absorption spectrum of the biological body 9 in 1st Embodiment. It is a figure which shows an example of a functional structure of the concentration measuring apparatus 2 of 2nd Embodiment. It is a figure which shows an example of a structure of the pressure sensitive part 26 in 2nd Embodiment. It is a figure which shows an example of a functional structure of the information processing part 200 in 2nd Embodiment. 11 is a flowchart showing an example of the flow of a process in which the information processing unit 200 according to the second embodiment acquires a glucose concentration. It is a figure showing an example of functional composition of concentration measuring device 1a of a modification. It is a figure which shows an example of a functional structure of the information processing part 100a in a modification. It is a figure which shows an example of the absorption spectrum of water and glucose used for simulation. It is a 1st figure which shows an example of the simulation result which shows the error with the true value of the concentration of glucose acquired by the multivariate analysis. It is a 2nd figure which shows an example of the simulation result which shows the error with the true value of the concentration of glucose acquired by the multivariate analysis. It is a figure which shows an example of the difference|error of the concentration of glucose and true value which the

concentration measuring devices

1, 2, and 1a acquired based on the learning result of machine learning.

Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. Hereinafter, as an example of an embodiment of the present invention, a form for measuring a blood glucose level (glucose concentration) in a living body will be described as an example, and it is assumed that a target component of measurement is glucose and a non-target component is water. To do. However, even when these target substances are different or the number of non-target components is plural, the present invention can be applied by the same concept. For example, glucose is used as the target component and water, protein and lipid are used as the non-target components, and hemoglobin is used as the target component and proteins and lipids are used as the non-target components.

(Outline of principle)
First, the outline of the principle of the embodiment will be described. Before explaining, some words are defined. Hereinafter, light having a wavelength at which glucose has a high absorbance is referred to as target component excitation light. Hereinafter, light having a wavelength at which water absorbs light is referred to as non-target component excitation light. Hereinafter, the target component excitation light is transmitted when the target component excitation light and the non-target component excitation light whose intensity is E1 (hereinafter referred to as “first non-target component excitation light”) are applied to the living body to be measured. The light is called the first target component transmitted light. Hereinafter, the transmitted light of the non-target component excitation light I1 when the target component excitation light and the first non-target component excitation light are applied to the living body to be measured is referred to as the first non-target component transmitted light. Hereinafter, the target component excitation light when the target component excitation light and the non-target component excitation light whose intensity is the second intensity E2 (hereinafter referred to as “second non-target component excitation light”) are irradiated to the living body to be measured. The transmitted light is referred to as the second target component transmitted light. The second strength E2 is a value larger than the first strength E1. Hereinafter, the transmitted light of the non-target component excitation light of the second intensity when the target component excitation light and the non-target component excitation light of the second intensity are applied to the living body to be measured is referred to as the second non-target component transmitted light.

Returning to the explanation of the outline of the principle of the embodiment. In the invention of the embodiment, the difference between the intensity of the first target component transmitted light and the intensity of the second target component transmitted light and the difference between the intensity of the first non-target component transmitted light and the intensity of the second non-target component transmitted light. Based on and, the glucose concentration is acquired.
When the intensity of the non-target component excitation light with which the living body 9 is irradiated changes, the temperature of water changes, so that the absorption spectrum of water shifts. Therefore, based on the difference between the intensity of the first target component transmitted light and the intensity of the second target component transmitted light, and the difference between the intensity of the first non-target component transmitted light and the intensity of the second non-target component transmitted light. , The shift amount of the absorption spectrum of water is acquired. The magnitude of the change in the absorption spectrum of glucose with respect to the change in the intensity of the excitation light of the non-target component with which the living body 9 is irradiated is so small as to be negligible with respect to the magnitude of the change in the absorption spectrum of water. This means that the difference between the intensity of the first target component transmitted light and the intensity of the second target component transmitted light is due to the change in the water absorption spectrum at the wavelength of the target component excitation light. Therefore, the influence of water on the absorbance of the target component excitation light is acquired based on the shift amount of the absorption spectrum of water and the difference between the intensity of the first target component transmitted light and the intensity of the second target component transmitted light. Since the influence of water on the absorbance of the target component excitation light is acquired, the influence of glucose on the absorbance of the target component excitation light based on the difference between the intensity of the first target component transmitted light and the intensity of the second target component transmitted light. Is obtained and the concentration of glucose is obtained.
In the invention of the embodiment, it is not always necessary to acquire transmitted light to acquire glucose concentration. In the invention of the embodiment, the concentration of glucose may be acquired by a physical quantity that is proportional to the intensity of the transmitted light of the light with which the living body 9 is irradiated, such as the amplitude of a vibration wave. The vibration waves include elastic waves and sound waves generated by heat waves.
The first intensity E1 may be 0. The first intensity E1 being 0 means that the first target component excitation light is not irradiated.
This is the end of the description of the outline of the principle of the embodiment.

(First embodiment)
FIG. 1 is a diagram illustrating an example of a functional configuration of the concentration measuring device 1 according to the first embodiment.
The concentration measuring device 1 includes a CPU (Central Processing Unit) 11, a memory 12, an auxiliary storage device 13 and the like connected by a bus, and executes a program to input the input unit 10, the first irradiation unit 14, and the second irradiation unit. It functions as a device including the light receiving unit 16, the light receiving unit 16, and the output unit 17. The concentration measuring apparatus 1 controls the operations of the input unit 10, the first irradiation unit 14, the second irradiation unit 15, and the light receiving unit 16 by executing the program, and based on the result of light reception by the light receiving unit 16, the purpose Get the concentration of an ingredient.

The auxiliary storage device 13 is configured by using a storage device such as a magnetic hard disk device or a semiconductor storage device. The auxiliary storage device 13 stores a program relating to the operation of the concentration measuring device 1.
The CPU 11 functions as the information processing unit 100 by executing the program stored in the memory 12 or the auxiliary storage device 13.
The input unit 10 is configured to include an input device such as a mouse, a keyboard, and a touch panel. The input unit 10 may be configured as an interface that connects these input devices to the own device. The input unit 10 receives an input of information to its own device. The input unit 10 outputs the input information to the information processing unit 100.

The 1st irradiation part 14 irradiates the living body 9 which is a measuring object with the light of the 1st wavelength. In the present embodiment, the light of the first wavelength is the target component excitation light. The light having the first wavelength is light having a wavelength of 1600 nanometers at which the absorbance of glucose is maximum. The light of the first wavelength does not necessarily have to have the wavelength at which the absorbance of glucose is maximum.
The light having the first wavelength may be, for example, light having a wavelength of 1600±70 nm, which is a wavelength in the vicinity of the wavelength at which the absorbance of glucose is substantially maximum. That is, the first wavelength may be a wavelength within a range of ±70 nanometers around the wavelength at which the absorbance of glucose is maximum.
The light having the first wavelength may be, for example, light having a wavelength of 1600±30 nanometers at which the absorbance of glucose is approximately maximum. When the light of the first wavelength is the light of the wavelength of 1600±30 nanometer where the absorbance of glucose is approximately maximum, the light of the first wavelength is more than the light of the wavelength of 1600±70 nanometer. The glucose concentration is accurately measured.
The light having the first wavelength may be, for example, light having a wavelength of 1600 nanometers at which the absorbance of glucose is approximately maximum. When the light of the first wavelength is the light of the wavelength of 1600 nanometers at which the absorbance of glucose is approximately maximum, the light of the first wavelength is higher than that of the light of the wavelength of 1600±30 nanometers. The glucose concentration is accurately measured.

The first irradiator 14 may irradiate light of the first wavelength in any way. The 1st irradiation part 14 may be equipped with a laser diode driver and a semiconductor laser, for example, and may irradiate the light of the 1st wavelength with a laser diode driver and a semiconductor laser. The 1st irradiation part 14 may be equipped with a general purpose cheap laser, and may irradiate the light of the wavelength of 1600 +/-70 nanometer, for example. The light emitted by the first irradiator 14 is CW (Continuous Wave) light.

In addition, the first irradiation unit 14 emits light of the first wavelength, a distance between the first light source, which is a light source of the light of the first wavelength, and the living body 9, an irradiation angle of the light, A first irradiation unit adjustment mechanism that is a mechanism that adjusts the radiation intensity of light of the first wavelength is provided. The first irradiation unit 14 controls the intensity of light emitted by the first irradiation unit adjustment mechanism. Since the first irradiation unit 14 includes the first irradiation unit adjustment mechanism, the concentration measuring device 1 can measure the glucose concentration with a constant accuracy regardless of the angle or distance between the first light source and the living body 9. You can However, it is not necessary to provide all the irradiation distance, angle, and intensity adjustment mechanisms, and an alternative function can be provided as necessary, but it can be appropriately omitted depending on the application and performance.

The second irradiation unit 15 irradiates the living body 9, which is the measurement target, with light having a second wavelength, which is a wavelength at which the absorbance of glucose as a target component is smaller than the absorbance of water as a non-target component. The light of the second wavelength is the non-target component excitation light.

The light of the second wavelength is, for example, light of 1450 nm, which is a wavelength at which the absorbance of glucose is smaller than that of water and the absorbance of water is maximum. It should be noted that the light of the second wavelength does not necessarily have the wavelength at which the absorbance of water is maximum.
For example, the light having the second wavelength may be light having a wavelength of 1450±70 nm, which is a wavelength in the vicinity of the wavelength where the absorbance of water is maximum. That is, the second wavelength may be a wavelength within a range of ±70 nanometers around the wavelength at which the absorbance of water is maximum.
The light having the second wavelength may be light having a wavelength of 1450±50 nanometers, which is a wavelength at which the absorbance of water is approximately maximum. When the light of the second wavelength is the light of the wavelength of 1450±50 nanometers, which is the wavelength at which the absorbance of water is approximately maximum, the light of the second wavelength is the light of the wavelength of 1450±70 nanometers. The glucose concentration is measured more accurately than in some cases.
The light having the second wavelength may be light having a wavelength of 1450 nm, which is a wavelength at which the absorbance of water is maximum. When the light of the second wavelength is the light of the wavelength of 1450 nm, which is the wavelength at which the absorbance of water is maximum, the light of the second wavelength is more than the light of the wavelength of 1450±50 nm. The glucose concentration can be accurately measured.

The second irradiation unit 15 may irradiate light of the second wavelength in any way. The second irradiation unit 15 may include, for example, a laser diode driver or a semiconductor laser, and the laser diode driver or the semiconductor laser may irradiate light of the second wavelength. The second irradiation unit 15 may include, for example, a general-purpose inexpensive laser, and may irradiate light having a wavelength of 1450±70 nanometers with the general-purpose inexpensive laser. The light emitted by the second irradiation unit 15 is CW (Continuous Wave) light.

Further, the second irradiation unit 15 irradiates the irradiation direction of the light of the second wavelength, the distance between the second light source, which is the light source of the light of the second wavelength, and the living body 9, the irradiation angle of the light, A second irradiation unit adjustment mechanism that is a mechanism that adjusts the radiation intensity of light of two wavelengths is provided. The second irradiation unit 15 controls the intensity of light emitted by the second irradiation unit adjustment mechanism. Since the second irradiation unit 15 includes the second irradiation unit adjustment mechanism, the concentration measuring device 1 can measure the glucose concentration with a constant accuracy regardless of the angle or distance between the second light source and the living body 9. You can However, it is not necessary to provide all the irradiation distance, angle, and intensity adjustment mechanisms, and an alternative function can be provided as necessary, but it can be appropriately omitted depending on the application and performance.

The light receiving unit 16 includes a detector such as lead sulfide (PbS) having a photoelectric effect or indium gallium arsenide (InGaAs) having a photovoltaic effect. The light receiving unit 16 receives the light emitted by the first irradiation unit 14 and transmitted through the living body 9. The light receiving unit 16 receives the light emitted by the second irradiation unit 15 and transmitted through the living body 9.
The light receiving unit 16 may receive the transmitted light of the light of the first wavelength and the transmitted light of the light of the second wavelength in any way. The light receiving unit 16 includes, for example, a bandpass filter that passes only the light of the first wavelength and the light of the second wavelength between the light receiving unit 16 and the living body 9, and thus the light of the first wavelength Only the transmitted light and the transmitted light of the light of the second wavelength may be received.

The output unit 17 outputs the concentration of the target component acquired by the own device. The output unit 17 may be any unit as long as it can output the concentration of the target component acquired by the own device. The output unit 17 may be configured to include, for example, an interface for connecting the own device to an external device. The output unit 17 may be configured to include a display device such as a CRT (Cathode Ray Tube) display, a liquid crystal display, and an organic EL (Electro-Luminescence) display. The output unit 17 may be configured as an interface that connects these display devices to the own device, for example.

FIG. 2 is a diagram showing the relationship between the absorption spectra of the target component and the non-target component of the light of the first wavelength and the light of the second wavelength in the first embodiment.
The horizontal axis of FIG. 2 represents wavelength. The vertical axis of FIG. 2 represents the absorbance. In FIG. 2, the target component is glucose. In FIG. 2, the non-target component is water. FIG. 2 shows that the first wavelength is 1600 nanometers where the absorption spectrum of glucose is approximately maximum. FIG. 2 shows that the second wavelength is 1450 nm, where the absorption spectrum of water is approximately maximum.

FIG. 3 is a diagram illustrating an example of a functional configuration of the information processing unit 100 according to the first embodiment.
The information processing unit 100 includes a control unit 110, a first intensity acquisition unit 120, a second intensity acquisition unit 130, a correction unit 140, a temperature information acquisition unit 150, and a concentration acquisition unit 160.

The control unit 110 controls the operations of the first irradiation unit 14, the second irradiation unit 15, and the light receiving unit 16. The control unit 110 controls, for example, the timing at which the first irradiation unit 14 and the second irradiation unit 15 irradiate the living body 9 with light. The control unit 110 can be configured to control the irradiation distance, angle, and intensity of the first irradiation unit 14 and the second irradiation unit 15, for example.

The 1st intensity acquisition part 120 acquires the intensity|strength of the light which the light-receiving part 16 received, when the living body 9 was irradiated with the light of the 1st wavelength, and the light of the 2nd wavelength of intensity|strength E1. When the living body 9 is irradiated with the light of the first wavelength and the light of the second wavelength having the intensity E1, the light received by the light receiving unit 16 is the first target component transmitted light and the first non-target component transmitted light. Is. When the living body 9 is irradiated with the light of the first wavelength and the light of the second wavelength having the intensity E1, the temperature of water is the light of the first wavelength and the light of the second wavelength having the intensity E2. 9 is lower than the temperature of water when irradiated. Hereinafter, the state of water when the living body 9 is irradiated with the light of the first wavelength and the light of the first wavelength having the intensity E1 is referred to as a low temperature state. Hereinafter, the light transmitted through the water in the low temperature state and received by the light receiving unit 16 is referred to as the transmitted light in the low temperature state.
The first intensity acquisition unit 120 outputs the acquired intensity of the transmitted light in the low temperature state to the temperature information acquisition unit 150 and the concentration acquisition unit 160.

The second intensity acquisition unit 130 acquires the intensity of the light received by the light receiving unit 16 when the living body 9 is irradiated with the light having the first wavelength and the light having the second wavelength having the intensity E2. When the living body 9 is irradiated with the light of the first wavelength and the light of the second wavelength having the intensity E2, the light received by the light receiving unit 16 is the second target component transmitted light and the second non-target component transmitted light. Is. Hereinafter, the state of water when the living body 9 is irradiated with the light of the first wavelength and the light of the second wavelength having the intensity E2 is referred to as a high temperature state. Hereinafter, the light transmitted through the water in the high temperature state and received by the light receiving unit 16 is referred to as the transmitted light in the high temperature state.
The second intensity acquisition unit 130 outputs the acquired intensity of the transmitted light in the high temperature state to the temperature information acquisition unit 150 and the concentration acquisition unit 160.

The correction unit 140 acquires the first correction coefficient based on information indicating the intensity of transmitted light in the low temperature state and the intensity of transmitted light in the high temperature state (hereinafter referred to as “first measurement result information”). The first correction coefficient is a value that corrects the intensity of transmitted light in the low temperature state and the intensity of transmitted light in the high temperature state, which are measurement results.
The first correction coefficient is a value that changes according to the amount of water. The first correction coefficient is a value that changes according to the wavelength of the light with which the living body 9 is irradiated. The first correction coefficient is a value according to the performance of the light receiving unit 16.
That is, the first correction coefficient is a value representing the influence of the environment. The environmental influence is, for example, the amount of water. The environmental influence is, for example, the absorbance of water for the first wavelength and the absorbance of water for the second wavelength. The influence of the environment is, for example, the performance of the light receiving unit 16.

The correction unit 140 may acquire the amount of water of the living body 9 based on the first measurement result information, and may acquire the first correction coefficient based on the acquired amount of water. The correction unit 140 acquires the amount of water of the living body 9 based on the first measurement result information, and acquires the first correction coefficient based on the acquired amount of water, the first wavelength, and the second wavelength. You may.

The correction unit 140 may acquire the amount of water in any way. The correction unit 140 may acquire the amount of water by multivariate analysis, for example. The correction unit 140 is based on, for example, a learning model that is learned in advance by a machine learning method such as a neural network and that represents the relationship between the intensity of transmitted light in a low temperature state, the intensity of transmitted light in a high temperature state, and the amount of water. The amount of water may be obtained. The correction unit 140 is, for example, the intensity of the transmitted light in the low temperature state, the intensity of the transmitted light in the high temperature state, the first wavelength, the second wavelength, and the amount of water, which have been learned in advance by a machine learning method such as a neural network. The amount of water may be acquired based on a learning model representing the relationship with.

The correction unit 140 corrects the intensity of the transmitted light in the low temperature state and the intensity of the transmitted light in the high temperature state based on the acquired first correction coefficient.
Hereinafter, for simplicity of description, the value after the correction of the intensity of the transmitted light in the low temperature state acquired by the first intensity acquisition unit 120 is also referred to as the intensity of the transmitted light in the low temperature state. Hereinafter, for simplicity of explanation, the value after correction of the intensity of transmitted light in the high temperature state acquired by the second intensity acquisition unit 130 is also referred to as the intensity of transmitted light in the high temperature state.

The temperature information acquisition unit 150 acquires information (hereinafter referred to as “temperature information”) regarding the temperature change of the living body 9 at the light irradiation location based on the first measurement result information. The temperature information is the information about the temperature change of the living body 9 at the light irradiation position, which is a part or all of the position where the light of the first wavelength and the light of the second wavelength are irradiated. It may be any information as long as it is, for example, the shift amount of the absorption spectrum of water.
The temperature information acquisition unit 150 may acquire the temperature information by any method as long as the temperature information can be acquired. The temperature information acquisition unit 150 may acquire the temperature information by multivariate analysis, for example. The temperature information acquisition unit 150 may acquire the temperature information based on a learning model that is learned in advance by a machine learning method such as a neural network and that represents the relationship between the first measurement result information and the temperature information.

The concentration acquisition unit 160 acquires the glucose concentration by the first concentration acquisition method based on the temperature information acquired by the temperature information acquisition unit 150 and the first measurement result information. The first concentration acquisition method may be any method as long as it can acquire the glucose concentration based on the temperature information and the first measurement result information. The first concentration acquisition method may be, for example, a multivariate analysis method. The first concentration acquisition method may be a method of acquiring the glucose concentration based on the first concentration learning model when the first concentration learning model is stored in the auxiliary storage device 13 in advance. The first concentration learning model is a learning model learned by machine learning such as a neural network, and is a learning model representing the relationship between the temperature information and the first measurement result information and the glucose concentration.

FIG. 4 is a flowchart showing an example of the flow of processing in which the information processing unit 100 according to the first embodiment acquires the glucose concentration.
The first irradiation unit 14 irradiates the living body 9 with light of the first wavelength, and the second irradiation unit 15 irradiates the living body 9 with light of the second wavelength having the intensity E1. The first intensity acquisition unit 120 acquires the intensity of transmitted light in a low temperature state. The first intensity acquisition unit 120 outputs the acquired intensity of the transmitted light in the low temperature state to the temperature information acquisition unit 150 and the concentration acquisition unit 160 (step S101). The irradiation by the first irradiation unit 14 and the irradiation by the second irradiation unit 15 may be performed at the same time, or may be executed with a predetermined time difference.

The first irradiation unit 14 irradiates the living body 9 with light of the first wavelength, and the second irradiation unit 15 irradiates the living body 9 with light of the second wavelength having the intensity E2. The second intensity acquisition unit 130 acquires the intensity of transmitted light in a high temperature state. The second intensity acquisition unit 130 outputs the acquired intensity of the transmitted light in the high temperature state to the temperature information acquisition unit 150 and the concentration acquisition unit 160. (Step S102). The irradiation by the first irradiation unit 14 and the irradiation by the second irradiation unit 15 may be performed at the same time, or may be executed with a predetermined time difference.

The correction unit 140 acquires the first correction coefficient based on the intensity of the transmitted light in the low temperature state and the intensity of the transmitted light in the high temperature state, and based on the acquired first correction coefficient, the intensity of the transmitted light in the low temperature state and the high temperature state. And the intensity of the transmitted light are corrected (step S103).

The temperature information acquisition unit 150 acquires temperature information based on the first measurement result information (step S104).
The concentration acquisition unit 160 acquires temperature information based on the first measurement result information and the temperature information, and acquires the glucose concentration by the first concentration acquisition method based on the temperature information and the first measurement result (step S105).

(Experimental result)
Here, FIGS. 5 and 6 show that the absorption spectrum of the living body 9 is changed by the irradiation of the living body 9 with the second wavelength in the first embodiment.
FIG. 5: is a figure which shows the simulation result which shows the dependence with respect to the intensity|strength of the 2nd wavelength of the absorption spectrum of the wavelengths 1590 nanometer to 1610 nanometer of the biological body 9 in 1st Embodiment.
FIG. 5 shows absorption spectra when the intensity of the second wavelength is 0 mW, 10 mW, 15 mW, and 20 mW.
FIG. 5 shows that the absorption spectrum changes as the intensity of the second wavelength changes. The amount of change in the absorption spectrum of the living body 9 is substantially the same as the amount of change in the absorption spectrum of water.

FIG. 6 is a diagram showing a simulation result showing the dependence of the absorption spectrum of the living body 9 from the wavelength 1386 nm to the wavelength 1392 nm on the intensity of the second wavelength in the first embodiment.
FIG. 6 shows absorption spectra when the intensity of the second wavelength is 0 mW, 10 mW, 15 mW, and 20 mW.
FIG. 6 shows that the absorption spectrum changes as the intensity of the second wavelength changes. The amount of change in the absorption spectrum of the living body 9 is substantially the same as the amount of change in the absorption spectrum of water.

FIG. 5 shows that, when the living body 9 is irradiated with the second wavelength of 20 mW, the change in absorbance is 1.4% at the wavelength of 1600 nm. FIG. 6 shows that when the living body 9 is irradiated with the second wavelength of 20 mW, the change in absorbance at the wavelength of 1390 nanometers is 1.7%. This means that the temperature of the living body 9 has changed by about 2 degrees due to the second wavelength of 20 mW.

As shown in FIGS. 5 and 6, the second wavelength causes a shift in the absorption spectrum of water of the living body 9 to the extent that the concentration measuring device 1 of the first embodiment can observe it. Therefore, the concentration measuring device 1 of the first embodiment can detect the shift of the water absorption spectrum of the living body 9, and can measure the glucose concentration based on the change of the water absorption spectrum of the living body 9.

Since the concentration measuring device 1 of the first embodiment configured as described above includes the temperature information acquisition unit 150 and the concentration acquisition unit 160, it is possible to acquire the glucose concentration of the living body 9 based on the first measurement result information. You can Therefore, the concentration measuring device 1 of the first embodiment can measure the concentration of the target component contained in the measurement target using a simple device.

Note that the concentration measuring device 1 does not necessarily need to measure the concentration of the target component by the transmitted light. The concentration measuring device 1 may measure the concentration of the target component by reflected light or scattered light.

(Second embodiment)
FIG. 7 is a diagram illustrating an example of a functional configuration of the concentration measuring device 2 according to the second embodiment. The concentration measuring device 2 according to the second embodiment modulates the intensity of the light with which the living body 9 is irradiated, and measures the glucose concentration at the target depth of the living body 9 using photoacoustic spectroscopy. Note that the target depth is the depth of the living body 9 whose glucose concentration should be measured.
Hereinafter, components having the same functions as those of the functional units included in the concentration measuring device 1 are denoted by the same reference numerals as those in FIGS. 1 and 3, and description thereof will be omitted.

The concentration measuring device 2 includes a CPU (Central Processing Unit) 21, a memory 22, an auxiliary storage device 23, and the like connected by a bus, and executes a program to input the input unit 10, the first irradiation unit 14, and the first modulation unit. It functions as a device including the section 24, the second irradiation section 15, the second modulation section 25, the pressure sensing section 26, and the output section 17. The concentration measuring device 2 controls the operations of the input unit 10, the first irradiation unit 14, the first modulation unit 24, the second irradiation unit 15, the second modulation unit 25, and the pressure-sensitive unit 26 by executing the program. The concentration of the target component is obtained based on the result obtained by the pressure sensing unit 26.

The first modulator 24 modulates the intensity of light emitted by the first irradiator 14 with a frequency ω1 (first frequency) and a frequency ω2 (second frequency). The frequency ω1 is a frequency at which the vibration wave generated in the living body 9 at the target depth reaches the pressure sensitive unit 26 when the living body 9 is irradiated with the light of the frequency ω1. Further, the frequency ω2 is a frequency at which, when the living body 9 is irradiated with light having the frequency ω2, the vibration wave generated in the living body 9 at the target depth is attenuated before reaching the pressure sensing unit 26. That is, the vibration wave generated in the living body 9 by the light modulated at the frequency ω1 reflects the vibration wave generated from the mixture of the vibration wave generated from the living body water existing near the dermis and the glucose in the blood vessel bed. On the other hand, the vibration wave generated in the living body 9 by the light modulated at the frequency ω2 mainly reflects the vibration wave generated from the body water existing near the dermis. The intensity of the vibration wave is inversely proportional to the frequency and the depth. The frequency ω2 is higher than the frequency ω1.

The second modulator 25 modulates the intensity of the light emitted by the second irradiator 15 at the frequency ω3, which is a frequency different from the frequencies ω1 and ω2. The concentration measuring device 2 does not necessarily need to include only one second modulator 25. The concentration measuring device 2 may include two or more second modulators 25.

FIG. 8 is a diagram showing an example of the structure of the pressure-sensitive section 26 in the second embodiment.
The pressure sensing unit 26 detects a vibration wave generated in the living body 9 by the light emitted by the first irradiation unit 14. The pressure-sensitive portion 26 includes a piezoelectric film 261 formed of a piezoelectric material such as polyvinylidene fluoride, and a holder 262 that holds the piezoelectric film 261 while applying tension to the piezoelectric film 261. When pressure is applied, the piezoelectric body generates a voltage proportional to the magnitude of the applied pressure. The piezoelectric body may be any piezoelectric body that generates a voltage proportional to the magnitude of the applied pressure when the pressure is applied. The piezoelectric body may be, for example, a microphone.
The holder 262 is made of an elastic material such as silicon rubber, covers one surface of the piezoelectric film 261, and is connected to the outer edge of the piezoelectric film 261. The holder 262 is formed so as not to come into contact with the piezoelectric film 261 except at the outer edge thereof.
As a result, by pressing the piezoelectric film 261 against the living body 9 and pressing the holder 262 against the living body 9, an elastic force of the holder 262 is generated outward with respect to the outer edge of the piezoelectric film 261, and the piezoelectric film 261 is tensioned. Given. As an example of the shape of the holder 262, as shown in FIG. 8, a shape in which the inner surface and the outer surface facing the piezoelectric film 261 are formed in a hemispherical shape can be mentioned.
The holder 262 may include an acoustic tube. An acoustic tube is a device that enhances vibration of sound waves generated by heat waves.
In this way, when the piezoelectric film 261 and the living body 9 are in contact with each other, tension is applied to the piezoelectric film 261 so that the piezoelectric film 261 and the living body 9 can be brought into close contact with each other.

FIG. 9 is a diagram illustrating an example of a functional configuration of the information processing unit 200 according to the second embodiment.
The information processing unit 200 includes a control unit 210, a first amplitude acquisition unit 220, a second amplitude acquisition unit 230, a correction unit 240, a temperature information acquisition unit 250, and a concentration acquisition unit 260.

The control unit 210 controls the operations of the first irradiation unit 14, the first modulation unit 24, the second irradiation unit 15, the second modulation unit 25, and the pressure sensitive unit 26. The control unit 210 controls, for example, the timing at which the first irradiation unit 14 and the second irradiation unit 15 irradiate the living body 9 with light. The controller 210 controls, for example, the modulation frequency of the first modulator 24 and the modulation frequency of the second modulator 25.

When the living body 9 is irradiated with the light of the first wavelength and the light of the second wavelength having the intensity E1, the first amplitude acquisition unit 220 detects the amplitude of the vibration wave detected by the pressure sensing unit 26 (hereinafter, “low temperature”). "Amplitude of state"). More specifically, the first amplitude acquisition unit 220 acquires the amplitude in the low temperature state based on the voltage generated by the piezoelectric body included in the pressure sensing unit 26. The amplitude of the vibration wave is proportional to the intensity of the transmitted light of the light with which the living body 9 is irradiated.

The second amplitude acquisition unit 230 detects the amplitude of the vibration wave detected by the pressure sensing unit 26 when the living body 9 is irradiated with the light of the first wavelength and the light of the second wavelength having the intensity E2 (hereinafter, referred to as “high temperature state”). "Amplitude of."). More specifically, the second amplitude acquisition unit 230 acquires the amplitude in the high temperature state based on the voltage generated by the piezoelectric body included in the pressure sensing unit 26. The second amplitude acquisition unit 230 outputs the acquired amplitude of the vibration wave to the correction unit 240.

The correction unit 240 acquires the second correction coefficient based on the information indicating the amplitude in the low temperature state and the amplitude in the high temperature state (hereinafter referred to as “second measurement result information”).
The second correction coefficient is a value that corrects the amplitude in the low temperature state and the amplitude in the high temperature state, which are the measurement results. The second correction coefficient is a value that changes according to the amount of water. The second correction coefficient is a value that changes depending on the wavelength of the light with which the living body 9 is irradiated. The second correction coefficient is a value according to the performance of the pressure sensitive unit 26.
That is, the second correction coefficient is a value representing the influence of the environment. The environmental influence is, for example, the amount of water, and the environmental influence is, for example, the absorbance of water for the first wavelength and the absorbance of water for the second wavelength. The influence of the environment is, for example, the performance of the pressure sensitive unit 26.

The correction unit 240 acquires the amount of water of the living body 9 based on the second measurement result information, and acquires the second correction coefficient based on the acquired amount of water. The correction unit 240 acquires the amount of water of the living body 9 based on the amplitude of the low temperature state and the amplitude of the high temperature state, and based on the acquired amount of water, the first wavelength, and the second wavelength, 2 The correction coefficient may be acquired.

The correction unit 240 may acquire the amount of water in any way. The correction unit 240 may acquire the amount of water by multivariate analysis, for example. The correction unit 240 acquires the amount of water based on, for example, a learning model that is learned in advance by a machine learning method such as a neural network and that represents the relationship between the amplitude of the low temperature state, the amplitude of the high temperature state, and the amount of water. May be. The correction unit 240, for example, learns the relationship between the amplitude in the low temperature state, the amplitude in the high temperature state, the first wavelength, the second wavelength, and the amount of water, which has been learned in advance by a machine learning method such as a neural network. The amount of water may be obtained based on the model.

The correction unit 240 corrects the amplitude in the low temperature state and the amplitude in the high temperature state based on the acquired second correction coefficient.
Hereinafter, for the sake of simplicity of description, the corrected value of the amplitude of the vibration wave acquired by the first amplitude acquisition unit 220 is also referred to as the low temperature state amplitude. Hereinafter, for the sake of simplicity of description, the corrected value of the amplitude of the vibration wave acquired by the second amplitude acquisition unit 230 is also referred to as the high temperature state amplitude.

The temperature information acquisition unit 250 acquires temperature information based on the second measurement result information. The temperature information acquisition unit 250 may acquire the temperature information by any method as long as the temperature information can be acquired. The temperature information acquisition unit 250 may acquire the temperature information by multivariate analysis, for example. The temperature information acquisition unit 250 may acquire the temperature information based on a learning model that is learned in advance by a machine learning method such as a neural network and that represents the relationship between the second measurement result information and the temperature information.

The concentration acquisition unit 260 acquires the glucose concentration in the living body 9 by the second concentration acquisition method based on the second measurement result information and the temperature information. The second concentration acquisition method may be any method as long as the glucose concentration can be acquired based on the second measurement result information and the temperature information. The second concentration acquisition method may be, for example, a multivariate analysis method. The second concentration acquisition method may be a method of acquiring the glucose concentration based on the second concentration learning model when the second concentration learning model is stored in advance in the auxiliary storage device 23. The second concentration learning model is a learning model learned by machine learning such as a neural network, and represents the relationship between the temperature information and the second measurement result information and the glucose concentration.

FIG. 10 is a flowchart showing an example of the flow of processing in which the information processing unit 200 according to the second embodiment acquires the glucose concentration.
The first irradiation unit 14 irradiates the living body 9 with light of the first wavelength, and the second irradiation unit 15 irradiates the living body 9 with light of the second wavelength having the intensity E1. The first amplitude acquisition unit 220 acquires the amplitude in the low temperature state based on the vibration wave detected by the pressure sensing unit 26. The first amplitude acquisition unit 220 outputs the acquired amplitude in the low temperature state to the correction unit 240 (step S201). The irradiation by the first irradiation unit 14 and the irradiation by the second irradiation unit 15 may be performed at the same time, or may be executed with a predetermined time difference.

The first irradiation unit 14 irradiates the living body 9 with light of the first wavelength, and the second irradiation unit 15 irradiates the living body 9 with light of the second wavelength having the intensity E2. The second amplitude acquisition unit 230 acquires the amplitude in the high temperature state based on the vibration wave detected by the pressure sensing unit 26. The second amplitude acquisition unit 230 outputs the acquired amplitude in the high temperature state to the correction unit 240 (step S202). The irradiation by the first irradiation unit 14 and the irradiation by the second irradiation unit 15 may be performed at the same time, or may be executed with a predetermined time difference.

The correction unit 240 acquires the second correction coefficient based on the amplitude of the low temperature state and the amplitude of the high temperature state, and corrects the amplitude of the low temperature state and the amplitude of the high temperature state based on the acquired second correction coefficient (step S203). ).

The temperature information acquisition unit 250 acquires temperature information based on the second measurement result information (step S204).
The concentration acquisition unit 260 acquires the glucose concentration by the second concentration acquisition method based on the temperature information and the second measurement result information (step S205).

Since the concentration measuring device 2 of the second embodiment configured as described above includes the concentration acquisition unit 260, the glucose concentration of the living body 9 can be acquired based on the second measurement result information. Therefore, the concentration measuring device 2 of the second embodiment can measure the concentration of the target component contained in the measurement target using a simple device.

Note that the pressure sensitive portion 26 in the second embodiment is not limited to the pressure sensitive portion 26 shown in FIG. For example, the pressure sensitive portion 26 may be formed only from the piezoelectric film 261, and may be attached or wound around the surface of the living body. Further, the pressure-sensitive section 26 may be an element such as a microphone or a piezoelectric element instead of the piezoelectric film 261, or a system that applies a laser beam to detect a minute fluctuation.

(Modification)
Note that the concentration measuring device 1 of the first embodiment and the concentration measuring device 2 of the second embodiment perform irradiation of excitation light under different conditions a plurality of times, so that the glucose concentration of the living body 9 is reduced. You may measure.
In this way, the

concentration measuring devices

1 and 2 measure the glucose concentration according to the measurement results of irradiation of the excitation light a plurality of times under different conditions, so that the

concentration measuring devices

1 and 2 measure the glucose concentration. The measurement accuracy can be improved.

The correction unit 140 does not necessarily need to acquire the first correction coefficient based on the first measurement result information. The correction unit 140 may acquire a value calculated in advance as the first correction coefficient by performing an experiment in which water having a wavelength of 1600 nanometers and light having a wavelength of 1450 nanometers is irradiated on water.
The correction unit 240 does not necessarily need to acquire the second correction coefficient based on the second measurement result information. The correction unit 240 may acquire a value calculated in advance as the second correction coefficient by performing an experiment in which water having a wavelength of 1600 nm and light having a wavelength of 1450 nm are irradiated.

In the concentration measuring device 1, the light with which the living body 9 is irradiated is not necessarily CW light. The light with which the living body 9 is irradiated may have a predetermined pattern and may be coded light. The light with which the living body 9 is irradiated may be encoded by the power of light, the irradiation time, or the observation wavelength.
As described above, the coded light is irradiated as the light for irradiating the living body 9, so that the measurement accuracy of the glucose concentration by the concentration measuring device 1 is higher than that when the light for irradiating the living body 9 is the CW light. Is improved.
Note that the concentration measuring device 1 includes, for example, a first modulator 24 and a second modulator 25, and controls the operations of the first modulator 24 and the second modulator 25 by the controller 110 so that the living body 9 can be controlled. The illuminating light may be encoded.
Note that the concentration measuring device 1a may irradiate the living body 9 with coded light having a predetermined irradiation pattern, similarly to the concentration measuring device 1.

The second wavelength is a wavelength at which the absorbance of glucose, which is the target component, is smaller than the absorbance of water, which is the non-target component, and is a wavelength that changes the absorption spectrum of water to a predetermined magnitude or more. Can be any wavelength.
If the second wavelength is a wavelength that shifts the absorption spectrum of the non-target component such that the shift amount of the absorption spectrum of the non-target component can be measured by the concentration measuring device 1, for example, Such a wavelength may be used. The light of the second wavelength may be a terahertz wave or ultraviolet light, for example.
The second wavelength may be the wavelength at the position of the inflection point of the absorption spectrum of the non-target component.

It should be noted that the

concentration measuring devices

1 and 2 do not necessarily need to include only one second irradiation unit 15. The concentration measuring device 1 and the concentration measuring device 2 may include two or more second irradiation units 15.
Hereinafter, for simplicity of description, a case where the concentration measuring device 1 includes two or more second irradiation units 15 will be described. However, in the following description, the concentration measuring device 2 includes two or more second irradiation units 15. The case is the same except that the glucose concentration is acquired based on the amplitude of the vibration wave instead of the glucose concentration is acquired based on the intensity of transmitted light.
Hereinafter, the concentration measuring device 1 including one or more second irradiation units 15 is referred to as a concentration measuring device 1a. Hereinafter, each of the second irradiation units 15 included in the concentration measuring device 1a is referred to as an nth irradiation unit 15-(n-1) (n is an integer of 2 or more and N or less. N is an integer of 2 or more). The second irradiation unit 15-1 is, for example, the second irradiation unit 15 in the first embodiment. The second irradiation unit 15 with n=3 is, for example, the third irradiation unit 15-2.

FIG. 11 is a diagram showing an example of a functional configuration of the concentration measuring device 1a according to the modification. Hereinafter, components having the same functions as those of the functional units included in the concentration measuring device 1 are denoted by the same reference numerals as those in FIGS. 1, 3, 7, and 9, and the description thereof will be omitted.

The concentration measuring device 1a includes an n-th irradiation unit 15-(n-1) in place of the second irradiation unit 15, a light receiving unit 16a in place of the light receiving unit 16, and an information processing unit 100 in place. The information processing unit 100a is included in the concentration measuring device 1.
The second irradiation unit 15-1 is the same as the second irradiation unit 15 in the first embodiment. The nth irradiator 15-(n-1) irradiates the light of the nth wavelength. The n-th irradiation unit 15-(n-1) is the same as the second irradiation unit 15 except that the wavelength of the light to be irradiated is the n-th wavelength. The nth wavelength is the non-target component excitation light.

The light receiving unit 16a not only receives the light emitted by the first irradiation unit 14 and transmitted through the living body 9 and the light emitted by the second irradiation unit 15 and transmitted through the living body 9, The light receiving unit 16 is different from the light receiving unit 16 in that the light emitted by the n-th irradiation unit 15-(n-1) and transmitted through the living body 9 is also received.

The information processing unit 100a replaces the result of irradiation of the living body 9 by the first irradiation unit 14 and the second irradiation unit 15 with N number of the first irradiation unit 14 and the n-th irradiation unit 15-(n-1). The information processing unit 100 differs from the information processing unit 100 in that the concentration of glucose is acquired based on the result of irradiation of the living body 9 by the irradiation unit.

FIG. 12 is a diagram illustrating an example of a functional configuration of the information processing unit 100a in the modified example.
The information processing unit 100 a includes a control unit 110 a in place of the control unit 110, a first intensity acquisition unit 120 a in place of the first intensity acquisition unit 120, and a second intensity acquisition unit 130 in place of the second intensity acquisition unit 130. The information processing unit 100a differs from the information processing unit 100a in that the two-strength acquisition unit 130a is provided.

The control unit 110a controls the operations of the first irradiation unit 14, the nth irradiation unit 15-(n-1), and the light receiving unit 16a. The control unit 110a controls the timing at which the first irradiation unit 14 and the nth irradiation unit 15-(n-1) irradiate the living body 9 with light, for example.

The first intensity acquisition unit 120a acquires the intensity of the transmitted light in the low temperature state and outputs it to the temperature information acquisition unit 150 and the concentration acquisition unit 160. The low temperature state in the concentration measuring device 1a is a state of water when the living body 9 is irradiated with the light of the first wavelength and the light of the nth wavelength having the intensity E1_n. The transmitted light in the low temperature state in the concentration measuring device 1a is the light transmitted through the water in the low temperature state and received by the light receiving unit 16a.

The second intensity acquisition unit 130a acquires the intensity of transmitted light in a high temperature state and outputs it to the temperature information acquisition unit 150 and the concentration acquisition unit 160. The high temperature state in the concentration measuring device 1a is a state of water when the living body 9 is irradiated with the light of the nth wavelength and the light of the nth wavelength of the intensity E2_n. The intensity E2_n is a value larger than the intensity E1_n. The transmitted light in the high temperature state in the concentration measuring device 1a is the light transmitted through the water in the high temperature state and received by the light receiving unit 16a.

The concentration measuring apparatus 1a of the modified example configured in this way acquires the glucose concentration based on the result of irradiating the living body 9 with a plurality of non-target component excitation lights. The number is greater than that of the concentration measuring device 1. Therefore, the concentration measuring device 1a can measure the glucose concentration with accuracy higher than the measurement precision of the glucose concentration by the concentration measuring device 1a.

In the concentration measuring device 1a of the modified example, the second wavelength and the third wavelength may be any wavelengths as long as they have a predetermined correlation with respect to the shift of the absorption spectrum of the non-target component. Good. The wavelength having a predetermined correlation is a wavelength that changes in correlation with each other due to the shift of the absorption spectrum of the non-target component.
The wavelengths having the predetermined correlation may be, for example, two wavelengths located at positions whose signs are opposite to each other with the wavelength of the peak of the absorption spectrum of the non-target component being the origin. The two wavelengths located at positions where the signs are opposite to each other with the wavelength of the peak of the absorption spectrum of the non-target component as the origin are, for example, when the non-target component is water, a wavelength of 1450+70 nm and a wavelength of 1450 nm. It may be two wavelengths, with a wavelength of -70 nanometers. Two wavelengths located at positions whose signs are opposite to each other with the wavelength of the peak of the absorption spectrum of the non-target component being the origin are, for example, when the non-target component is water, a wavelength of 1450+20 nanometers and a wavelength of 1450 nm. It may be two wavelengths, with a wavelength of -50 nanometers. Two wavelengths located at positions where the signs of the peaks of the absorption spectrum of the non-target component are opposite to each other are the inflection points where the signs of the peaks of the absorption spectrum of the non-target component are opposite to the origin. The wavelength may be located at the position of.

The wavelengths having a predetermined correlation may be, for example, two wavelengths located at positions whose signs are opposite to each other with the wavelength of the inflection point of the absorption spectrum of the non-target component as the origin. Two wavelengths located at positions whose signs are opposite to each other with the wavelength of the inflection point of the absorption spectrum of the non-target component being the origin are, for example, a wavelength of H+10 nanometers and a wavelength of H-10 nanometers. It may be one wavelength. H is the wavelength of the inflection point of the absorption spectrum of the non-target component. Two wavelengths located at positions whose signs are opposite to each other with the wavelength of the inflection point of the absorption spectrum of the non-target component being the origin are, for example, a wavelength of H+7 nanometers and a wavelength of H-5 nanometers. It may be one wavelength.

When the concentration measuring device 1a of the modified example has three or more irradiation units that irradiate the non-target component excitation light, the wavelengths of the respective non-target component excitation lights are wavelengths having a predetermined correlation. is there. The predetermined correlation between three or more non-target component excitation lights means that, for example, approximately half of the wavelengths are located on the positive side with the wavelength of the peak of the absorption spectrum of the non-target component as the origin, and the remaining non-target components. The relationship may be such that the wavelength of the component excitation light is located on the negative side.
Up to this point, the description of the modified concentration measuring device 1a shown in FIG. 11 is completed.

Note that the

information processing units

100 and 100a may acquire the amount of water based on the first measurement result information. The

information processing units

100 and 100a may acquire the amount of water in any way. The

information processing units

100 and 100a may acquire the amount of water by multivariate analysis, for example. The

information processing units

100 and 100a are, for example, learning models that have been learned in advance by a machine learning method such as a neural network, and the intensity of transmitted light in a low temperature state, the intensity of transmitted light in a high temperature state, and the amount of water. The amount of water may be acquired based on a learning model representing the relationship.

When the first wavelength is a wavelength belonging to a wavelength band in which the change in the absorbance of water with respect to the temperature change is linear, the concentration measuring device 1 and the concentration measuring device 2 are machine-learned by a method of multivariate analysis. The glucose concentration can be measured with an accuracy equal to or higher than the measurement accuracy of the glucose concentration measured by the method.

On the other hand, when the first wavelength is a wavelength belonging to a wavelength band in which the change of the absorbance of water with respect to the temperature change is non-linear, the concentration measuring device 1 and the concentration measuring device 2 are often subjected to the machine learning method. The glucose concentration can be measured with accuracy higher than the measurement accuracy of the glucose concentration measured by the method of variable analysis.
In the case where the concentration measuring device 1 and the concentration measuring device 2 measure the concentration by the method of multivariate analysis, there is a correlation between the wavelengths with respect to the change occurring in the living body 9 for each wavelength with which the living body 9 is irradiated. The measurement accuracy is improved. On the other hand, in the case where the concentration measuring device 1 and the concentration measuring device 2 measure the concentration by the method of machine learning, the change occurring in the living body 9 for each wavelength with which the living body 9 is irradiated may not necessarily have a correlation.

The results of simulating the error between the glucose concentration and the true value acquired by the multivariate analysis by the

concentration measuring devices

1, 2 and 1a will be described with reference to FIGS. 13 to 15.
FIG. 13 is a diagram showing an example of absorption spectra of water and glucose used in the simulation.
The water used in the simulation has a spectrum with a maximum at 1450 nanometers. Glucose used in the simulation is a spectrum having a maximum value at 1600 nanometers. In FIG. 13, the analysis wavelength point indicates a candidate for the second wavelength in the simulation.

FIG. 14 shows an error from the true value of the glucose concentration obtained by the multivariate analysis by the

concentration measuring devices

1, 2 and 1a when only the light of the second wavelength is irradiated as the non-target component excitation light. It is a figure which shows an example of a simulation result.
The simulation is an absorption spectrum of the living body 9 when the temperature of the living body 9 is 28° C. and the glucose concentration is 0%, 0.05%, 0.1%, 0.15% and 0.2% respectively. The absorption spectrum of the living body 9 and the absorption spectrum of the living body 9 when the temperature of the living body 9 is 30° C. and the concentrations of glucose are 0%, 0.05%, 0.1%, 0.15% and 0.2%. The absorption spectrum of the living body 9 in each case and the absorption spectrum of the living body 9 when the temperature of the living body 9 is 32° C. and the concentration of glucose are 0%, 0.05%, 0.1%, 0.15%, 0 A total of 15 spectra with the absorption spectrum of organism 9 in each case of 0.2% were carried out as known.
The simulation was performed assuming a true value of 31° C. and a glucose concentration of 0.07%.

The horizontal axis of FIG. 14 represents wavelength. The vertical axis of FIG. 14 represents the error. In FIG. 14, the water estimation error is an error calculated by the simulation, and represents an error between the amount of water acquired by the

concentration measuring devices

1, 2 and 1a and the true value. In FIG. 14, the Glc estimation error is an error calculated by the simulation, and represents an error between the glucose concentration acquired by the

concentration measuring devices

1, 2 and 1a and the true value. In FIG. 14, the temperature estimation error is the error calculated by the simulation, and represents the error between the temperature of water and the true value acquired by the

concentration measuring devices

1, 2 and 1a.
FIG. 14 shows that the glucose concentration acquired by the multivariate analysis by the

concentration measuring devices

1, 2 and 1a when the non-target component excitation light is irradiated with only the light of the second wavelength has an error of 20 from the true value. % To 25%.

FIG. 15 shows the concentration of glucose acquired by the multivariate analysis by the

concentration measuring devices

1, 2 and 1a when the light of the second wavelength and the light of the third wavelength are irradiated as the non-target component excitation light. It is a figure which shows an example of the simulation result which shows the error with a true value.
The simulation was performed assuming that the same information as in FIG. 14 is known. That is, also in FIG. 15, the simulation is the absorption spectrum of the living body 9 when the temperature of the living body 9 is 28° C., and the glucose concentrations are 0%, 0.05%, 0.1%, 0.15%, 0. The absorption spectrum of the living body 9 in each case of 2% and the absorption spectrum of the living body 9 when the temperature of the living body 9 is 30° C. and the concentration of glucose is 0%, 0.05%, 0.1%, 0.15. % And 0.2% of the absorption spectrum of the living body 9 and the absorption spectrum of the living body 9 when the temperature of the living body 9 is 32° C. and the glucose concentrations are 0%, 0.05% and 0.1%, respectively. , 0.15%, 0.2% in each case, and a total of 15 spectra with the absorption spectrum of living body 9 were performed as known.
Also, as in FIG. 14, the simulation was performed assuming that the true value was 31° C. and the glucose concentration was 0.07%.

The horizontal axis of FIG. 15 represents wavelength. The vertical axis of FIG. 15 represents the error. FIG. 15 shows that when the light of the second wavelength and the light of the third wavelength longer than 1450 nm are irradiated as the non-target component excitation light, the

concentration measuring devices

1, 2 and 1a are analyzed by the multivariate analysis. The obtained glucose concentration has an error of 5% to 10% from the true value.
In addition, FIG. 15 shows that when the light of the second wavelength and the light of the third wavelength of 1450 nm or less are irradiated as the non-target component excitation light, the

concentration measuring devices

1, 2 and 1 a are multivariate. The glucose concentration obtained by the analysis shows that the error from the true value is 20% to 25%.
When the light of the second wavelength and the light of the third wavelength of 1450 nm or less are irradiated as the non-target component excitation light, the

concentration measuring devices

1, 2 and 1a are based on the learning result of the machine learning. It is desirable to obtain the glucose concentration.

FIG. 16 is a diagram showing an example of the error between the glucose concentration and the true value acquired by the

concentration measuring devices

1, 2 and 1a based on the learning result of machine learning.
The machine learning teacher data for obtaining the result of FIG. 16 is that the true value of the glucose concentration is changed in steps of 0.01% from 0.08 to 0.17%, and the temperature is changed from 35° C. to 37° C. This is the concentration of the glucose concentration acquired by the

concentration measuring devices

1, 2 and 1a when changed in steps of 0.2° C.
FIG. 16 shows the concentration measurement in the case where the

concentration measuring devices

1, 2 and 1a acquire the concentration of glucose having a true value of 0.085 to 0.165% at a temperature of 36° C. based on the learned model. The error between the concentration of glucose acquired by the

devices

1, 2 and 1a and the true value is shown.
FIG. 16 also shows the error between the temperature and the true value acquired by the

concentration measuring devices

1, 2 and 1a.
FIG. 16 shows that the error between the concentration of glucose and the true value acquired by the

concentration measuring devices

1, 2 and 1a is 2% or less when based on the learned model.

All or part of each function of the

concentration measurement devices

1, 2 and 1a is realized by using hardware such as ASIC (Application Specific Integrated Circuit), PLD (Programmable Logic Device) and FPGA (Field Programmable Gate Array). May be done. The program may be recorded in a computer-readable recording medium. The computer-readable recording medium is, for example, a portable medium such as a flexible disk, a magneto-optical disk, a ROM, a CD-ROM, or a storage device such as a hard disk built in a computer system. The program may be transmitted via a telecommunication line.

Note that the

information processing units

100, 200, and 100a may be implemented by using a plurality of information processing devices communicatively connected via a network. Further, the

information processing units

100, 200 and 100a may output the measurement result. In addition, the

information processing units

100, 200, and 100a may include a display device that displays the measurement result. In this case, the functional units included in the

information processing units

100, 200, and 100a may be distributed and implemented in a plurality of information processing devices. For example, the control unit 110, the first intensity acquisition unit 120 and the second intensity acquisition unit 130, the correction unit 140, the temperature information acquisition unit 150, and the concentration acquisition unit 160 may be implemented in different information processing devices. ..

The

concentration measuring devices

1, 2 and 1a may be implemented by using a plurality of devices communicably connected via a network.
In this case, the concentration measuring device 1 includes, for example, a light measuring device including the control unit 110, the first irradiation unit 14, the second irradiation unit 15, and the light receiving unit 16, the first intensity acquisition unit 120, and the second intensity acquisition unit 130. , A processing unit including the correction unit 140, the temperature information acquisition unit 150, and the concentration acquisition unit 160.

Note that the strength E2 does not necessarily have to be stronger than the strength E1 as long as the strength E2 is different from the strength E1. The intensity of the transmitted light and the amplitude of the vibration wave are physical quantities whose squared dimension is proportional to energy. The intensity of the transmitted light and the amplitude of the vibration wave are examples of physical quantities due to changes in the measurement target. In addition, the 1st intensity|strength acquisition part 120 and the 1st amplitude acquisition part 220 are examples of a 1st acquisition part. The second intensity acquisition unit 130 and the second amplitude acquisition unit 230 are examples of the second acquisition unit. The strength E1 is an example of the first strength. The strength E2 is an example of the second strength. The third irradiation unit 15-2 to the Nth irradiation unit 15-(N-1) are examples of M irradiation units. Note that M is an integer of 1 or more. The shift amount of the absorption spectrum is an example of change in the absorption spectrum. The change in the absorption spectrum is not limited to the change in the shift amount and may be the change in the shape of the absorption spectrum.

The embodiment of the present invention has been described in detail above with reference to the drawings, but the specific configuration is not limited to this embodiment, and includes a design etc. within the scope not departing from the gist of the present invention.

1, 2, 1a... Concentration measuring device, 11, 21... CPU, 12, 22... Memory, 13, 23... Auxiliary storage device, 14... First irradiation unit, 15... Second irradiation unit, 16, 16a... Light receiving unit , 100, 100a... Information processing unit, 110, 210... Control unit, 120... First intensity acquisition unit, 130... Second intensity acquisition unit, 140, 240... Correction unit, 150, 250... Temperature information acquisition unit, 160, 260... concentration acquisition section, 24... first modulation section, 25... second modulation section, 26... pressure sensitive section, 220... first amplitude acquisition section, 230... second amplitude acquisition section

Claims

A first irradiation unit that irradiates a measurement target having a target component and a non-target component with light having a first wavelength;
A second irradiation unit that irradiates the measurement target with light having a second wavelength that is different from the first wavelength;
The measurement is performed when the first irradiation unit irradiates the measurement target with light having the first wavelength and the second irradiation unit irradiates the measurement target with light having the second wavelength at the first intensity. A first acquisition unit that acquires a physical quantity resulting from a change in the target;
The first irradiation unit irradiates the measurement target with light of the first wavelength, and the second irradiation unit measures the measurement target with light of the second wavelength at a second intensity different from the first intensity. A second acquisition unit that acquires a physical quantity resulting from a change in the measurement target when the object is irradiated with
A temperature information acquisition unit that acquires temperature information that is information related to a temperature change of the measurement target based on the physical quantity acquired by the first acquisition unit and the physical quantity acquired by the second acquisition unit;
A concentration acquisition unit that acquires the concentration of the non-target component based on the temperature information, the physical quantity acquired by the first acquisition unit, and the physical quantity acquired by the second acquisition unit;
A concentration measuring device comprising.
The concentration acquisition unit acquires the concentration by multivariate analysis,
The concentration measuring device according to claim 1.
The concentration acquisition unit is a learning model that has been learned in advance, and is a learning model that represents the relationship between the physical quantity acquired by the first acquisition unit, the physical quantity acquired by the second acquisition unit, the temperature information, and the concentration. Based on, obtaining the concentration,
The concentration measuring device according to claim 1.
The second wavelength is a wavelength at which the absorbance of the target component is smaller than the absorbance of the non-target component,
The concentration measuring device according to claim 1.
The second wavelength is a wavelength that changes the absorption spectrum of the non-target component to a predetermined magnitude or more,
The concentration measuring device according to claim 4.
The second wavelength is a wavelength at which the absorbance of the non-target component is maximum,
The concentration measuring device according to claim 5.
The second wavelength is a wavelength within a range of ±70 nanometers centering on the wavelength at which the absorbance of the non-target component is maximum,
The concentration measuring device according to claim 5.
The first wavelength is a wavelength within a range of ±70 nanometers around the wavelength at which the absorbance of the target component is maximum,
The concentration measuring device according to claim 1.
The first wavelength is a wavelength at which the absorbance of the target component is maximum,
The concentration measuring device according to claim 2.
Based on the physical quantity acquired by the first acquisition unit and the physical quantity acquired by the second acquisition unit, a correction coefficient that is a value representing the influence of the environment on the physical quantity is acquired, and by the acquired correction coefficient, A correction unit that corrects the physical quantity acquired by the first acquisition unit and the physical quantity acquired by the second acquisition unit,
The concentration measuring device according to claim 1, further comprising:
The environmental impact is the amount of the non-target component,
The concentration measuring device according to claim 10.
The influence of the environment is the absorbance of the non-target component for the first wavelength and the absorbance of the non-target component for the second wavelength.
The concentration measuring device according to claim 10.
The influence of the environment is the performance of the light receiving unit that receives the light of the first wavelength,
The concentration measuring device according to claim 10.
At least one of the light of the first wavelength and the light of the second wavelength is coded light,
The concentration measuring device according to claim 1.
Further, M (M is an integer of 1 or more) irradiation units for irradiating a measurement object having a target component and a non-target component with light,
The concentration measuring device according to claim 1.
The wavelength of the light emitted by at least one of the M irradiation units is the third wavelength,
The second wavelength and the third wavelength are wavelengths having a predetermined correlation regarding the shift of the absorption spectrum of the non-target component,
The concentration measuring device according to claim 15.
The second wavelength and the third wavelength are wavelengths located at positions with opposite signs with respect to the wavelength of the peak of the absorption spectrum of the non-target component as the origin.
The concentration measuring device according to claim 16.
The second wavelength and the third wavelength are wavelengths located at positions whose signs are opposite to each other with the wavelength of the inflection point of the absorption spectrum of the non-target component being the origin.
The concentration measuring device according to claim 16.
The physical quantity is the intensity of transmitted light, scattered light, or reflected light of the light with which the measurement target is irradiated,
The concentration measuring device according to claim 1.
The physical quantity is the intensity of transmitted light of the light applied to the measurement object,
The concentration measuring device according to claim 19.
The physical quantity is the amplitude of an oscillating wave generated in the measurement object by the light applied to the measurement object,
The concentration measuring device according to claim 1.
The vibration wave is the amplitude of the elastic wave generated in the measurement object by the light applied to the measurement object,
The concentration measuring device according to claim 21.
The vibration wave is the amplitude of a thermal wave generated in the measurement object by the light applied to the measurement object,
The concentration measuring device according to claim 21.
A piezoelectric body that generates a voltage proportional to the magnitude of the pressure when pressure is applied,
A holder for applying tension to the piezoelectric body to bring the piezoelectric body into close contact with the measurement target,
The first acquisition unit and the second acquisition unit acquire the physical quantity based on the voltage generated by the piezoelectric body,
The concentration measuring device according to claim 21.
The temperature information is a shift amount of the absorption spectrum of the non-target component,
The concentration measuring device according to claim 1.
A first irradiation unit that irradiates a measurement target having a target component and a non-target component with light having a first wavelength, and irradiates the measurement target with light having a second wavelength that is different from the first wavelength. A second irradiation unit and the first irradiation unit irradiate the measurement target with light having the first wavelength, and the second irradiation unit irradiates the measurement target with light having the second wavelength at the first intensity. In that case, a first acquisition unit that acquires a physical quantity resulting from a change in the measurement target, and the first irradiation unit irradiates the measurement target with light having the first wavelength, and the second irradiation unit A second acquisition unit that acquires a physical quantity resulting from a change in the measurement target when the measurement target is irradiated with light having a second wavelength at a second intensity different from the first intensity; and the first acquisition A temperature information acquisition unit that acquires temperature information, which is information related to a temperature change of the measurement target, based on the physical quantity acquired by the unit and the physical quantity acquired by the second acquisition unit; and the temperature information and the first acquisition unit. A concentration measuring method performed by a concentration measuring device comprising: a concentration acquiring unit that acquires the concentration of the non-target component based on the acquired physical amount and the physical amount acquired by the second acquiring unit,
A first irradiation step of irradiating the measurement object with the light of the first wavelength;
A second irradiation step of irradiating the measurement target with light of the second wavelength;
The measurement is performed when the first irradiation unit irradiates the measurement target with light having the first wavelength and the second irradiation unit irradiates the measurement target with light having the second wavelength at the first intensity. A first acquisition step of acquiring a physical quantity resulting from a change in the target,
The first irradiation unit irradiates the measurement target with light of the first wavelength, and the second irradiation unit measures the measurement target with light of the second wavelength at a second intensity different from the first intensity. A second acquisition step of acquiring a physical quantity resulting from the change of the measurement target when the irradiation is performed on
A temperature information acquisition step of acquiring temperature information, which is information regarding a temperature change of the measurement target, based on the physical quantity acquired by the first acquisition section and the physical quantity acquired by the second acquisition section;
A concentration acquisition step of acquiring the concentration of the non-target component based on the temperature information, the physical quantity acquired by the first acquisition unit, and the physical quantity acquired by the second acquisition unit;
And a method for measuring concentration.
A non-transitory recording medium that stores a program for causing a computer to function as the concentration measuring device according to claim 1.