WO2020108442A2

WO2020108442A2 - Substance for treating and/or preventing motor system diseases, and design method and preparation method therefor

Info

Publication number: WO2020108442A2
Application number: PCT/CN2019/120689
Authority: WO
Inventors: 董福田
Original assignee: 董福田
Priority date: 2018-11-28
Filing date: 2019-11-25
Publication date: 2020-06-04
Also published as: CN116096419A

Description

Substance for treating and/or preventing diseases of sports system, and design method and preparation method thereof

Technical field

The invention belongs to the fields of medicines, health foods, food additives and the like, and specifically relates to substances for the treatment and/or prevention of sports system diseases and their design methods and preparation methods.

Background technique

The motor system consists of three organs: bone, joint and skeletal muscle. The bones are connected together in different forms to form the bones. It forms the basic form of the human body and provides attachment to the muscles. Under the innervation, the muscles contract and pull the bones they attach to, using the movable bone connection as the hub to produce the lever movement. The sports system has the functions of exercising, supporting and protecting the human body. Sports system diseases are diseases that occur in bones, joints, muscles, and ligaments. It can be manifested as a local disease or a systemic disease. Local cases such as trauma, fracture, dislocation, deformity, etc. Systemic diseases such as rheumatoid arthritis can occur in the hands, wrists, knees, and hips.

Sports system diseases are common diseases and frequently-occurring diseases that seriously endanger people's health, and have already constituted major problems affecting public health. Not only the incidence of sports system diseases is high, but many diseases start with hidden attacks, and the disease period is long and difficult to cure, which puts a heavy burden on society and the national economy.

The present invention recognizes life from the perspective of a structural system based on a new medical model—structural information medicine, restores the dynamic balance of the structural system by allowing the body to recognize the information of a specific structure, and using the adaptive and self-organizing functions of the body structural system To achieve the purpose of preventing and curing diseases.

1. Medical models of traditional Chinese medicine and western medicine

The existing medical system mainly includes Western medicine and traditional Chinese medicine. Western medicine is based on the microscopic local material structure, which is longer than the lattice and shorter than the poor theory. Traditional Chinese medicine is based on the macroscopic overall functional system, which is good at poor theory and poor at the lattice. The two have complementary strengths, but the theoretical system and research methods are in opposition to each other. Western medicine mainly relies on scientific experiments, using basic research methods such as anatomy and physiology, biochemistry and molecular sciences, and clinical trials, to analyze the material nature of diseases through segmentation reduction theory. Therefore, Western medicine pays more attention to the structural material of the lesion, analyzes the changes of the specific structure, and then uses chemical drugs, surgery, radiation, etc. to directly damage the insufficiency at the level of the local material structure, such as H2 receptor antagonists for the treatment of hyperacidity , Hormone replacement therapy, etc. This kind of treatment takes effect quickly, and it has been effective in some acute diseases, surgical diseases and infectious diseases. However, Western medicine lacks a holistic understanding of the body. This treatment can only temporarily solve the problem of local structure. Long-term use will have an adverse effect on other structures of the body and destroy the balance of the body. In fact, since 2010, one-third of the world's diseases are drug-induced diseases, these diseases are caused by the inevitable side effects of drugs. Moreover, Western medicine has little effect on chronic degenerative diseases with complex pathogenic factors and multiple factors such as cardio-cerebrovascular disease, multiple sclerosis, and senile dementia, and it is difficult to contain its increasing morbidity and mortality.

Traditional Chinese medicine regards life as a whole, unifying people with society, psychology, and environment, with syndrome differentiation as the core, reflecting the objective laws of nature and people, health and disease. The health of TCM is about the relative balance of the body's yin and yang in the subjective and objective environment, and the coordinated and orderly state, that is, the balance of the functional system. When this balance is broken, the order and steady state of the human body are disturbed and destroyed, that is, the functional system of the human body is out of balance, and diseases will occur. Traditional Chinese medicine diagnoses the nature of the disease by asking a lot of information about the functional system, and then adjusts the functional system of the body through drugs, acupuncture, massage, etc., as a whole, it will damage the surplus, make up for its deficiencies, correct the evil and restore the body. Steady state. The traditional Chinese medicine method takes effect slowly, but it can reduce the toxic and side effects of the use of alternative methods or antagonists, and it is quite effective in disease prevention and health rehabilitation.

All in all, Western medicine pays more attention to the micro-structural balance, and Chinese medicine pays more attention to the macro-functional system balance. The purpose of both is to correct the imbalance of the body on different levels. But the two are completely different in epistemology and methodology of disease and health. In order to make the two medical models complement each other, we need to integrate the two with a more inclusive perspective and theory to develop a more effective treatment of disease Substances make a more outstanding contribution to human health.

2. Structural Information Medicine

(1) Integrate the basic theory of Western medicine and traditional Chinese medicine with a structural system

After the Big Bang, positive and negative charges appear, and the two interact to form a simple structure of hydrogen, and then the interaction between the structures forms a more complex structure, which eventually forms a macroscopic matter, including the entire biological world, so all things in the universe are unified.于结构。 Yu structure. The matter, energy, and information that make up everything in the universe are also unified in structure. First of all, different structures constitute different substances. Matter is a specific structure and the basis for realizing functions. The structure and function of a living system are matched. What kind of specific structure has a specific function, and the specific structure changes. Naturally, it will affect the specific functions of the corresponding system; secondly, the bond energy of the interaction between the structures is a relatively abstract structure, indicating the stability of the structure, and the energy is the internal power of the interconnection of the structures; finally, the relationship between the structures and Order is information, and information is the most abstract structure among the three. It plays a role in combining and controlling matter and energy, reflecting the internal laws and essence of the structure. For example, the nature of a living being is determined by its abstract structural genes. Therefore, structure is the unity of matter, energy and information, that is, the unity of concrete structure and abstract structure.

Biology is an organic system, essentially an organic structure system dominated by abstract structures. A structural system is an organic structural whole with a certain function composed of a relatively stable connection between several elements, organizational order and its spatial and temporal relationship. Any element itself is also a structural system, a subsystem that constitutes the original system, and the subsystem must be composed of sub-subsystems... The structural system of biology is composed of structural subsystems of different levels, such as the immune system, gastrointestinal system Biology itself is a subsystem of a larger structural system. For example, biology is a subsystem of a larger structural system in nature, and maintains its own existence and reproduction in the constant exchange of matter, energy and information with nature.

DNA, as the genetic material of living things, stores all the information in the process of life activities, including growth, development, aging and death. Dr. Roger Williams showed in the biochemical individualization theory that the differences in the biochemical composition of the human body stem from the differences in genes and gene expression, that is, the differences in the molecular spatial structure of gene expression. The Nobel Prize in Physiology, Dr. Reagan Jinchuan, showed that all diseases except trauma are related to genes. The causes of disease mainly include two aspects: first, the structure of the body is damaged or changed by the structural environment; second, the inappropriate expression of genes, the fundamental cause of structural imbalance is the change in abstract structure, that is, the change in gene expression, Such as abnormal histone acetylation, methylation, abnormal gene methylation, etc. If the specific structure changes, as long as the genes related to the structure can be expressed normally, the body's metabolism will gradually replace the structure with the diseased structure by the normal structure, and the body can return to a healthy state. Therefore, the core of biological health lies in genes and gene expression.

Western medicine studies the specific structural changes, using the disease as a model and using the model to treat the disease. Western medicine focuses on the study of local tissues and functions in structural systems, which can be inspected by instruments to penetrate into specific and microscopic material structures, focusing on and emphasizing the existence of specific human material structures and forms, such as anatomy and molecular biology. , Cytology, histology and embryology, etc. These disciplines all use experimental methods to study and observe the specific structure in the structural system from different angles, which is insufficient in abstract thinking and ignores the integrity of the body as a structural system. Therefore, it is easy to have limitations in understanding and practice. Western medicine mainly directly intervenes in specific structures, and uses drugs to change and affect the local structure of the body to achieve a new balance, including the study of genes, and also tends to directly change genes. Or gene expression. The traditional Chinese medicine is a human model, which is under the guidance of holism-led thinking, to study the functions of various organs of the body and the interrelationships and functions of the functions. Chinese medicine does not detect the specific material structure, but diagnoses the disease through the performance of the function and external information. However, the function is determined by the structure. The essence of the functional system is the structural system. The symbiosis between the functional subsystems is essentially the mutual promotion and mutual restriction between the structural subsystems. Traditional Chinese medicine achieves overall balance by adjusting the functional order and strength of the body. Its essence is to restore the dynamic balance of the structural system. However, due to the lack of in-depth understanding of the specific body structure, it also has great limitations. Western medicine mainly builds a disease model from the perspective of microstructure, while traditional Chinese medicine builds a life model from the perspective of macrofunction. The microstructure of Western medicine has found the material basis for the TCM certificate, that is, the TCM certificate has the material support of gene expression, that is, the structural support, which is essentially a microscopic structural imbalance. In the structural system, based on the unity of micro and macro, partial and whole, concrete and abstract, the specific structure of local and micro can be used to identify the specific structure through the body and convert the specific structure into abstract structural information. Stimulate the adaptive and self-organizing functions of the body to adjust the expression of genes or genes, and regain the balance of the structural system.

As a system, a structural system has the basic characteristics of system integrity, openness, stability, and self-organization. Compared with the environment, the system is the unity of closedness and openness. The interaction between structures within a structural system is premised on the interaction between structure and environment, and is conditioned on the external environment of the structure. The evolution of the same structural system depends on the external structure. Gene expression changes and adjustments in accordance with changes in external structure are the basic functions of organisms to adapt to the environment, maintain survival, and maintain their own health. If they lack such functions, they will generally be eliminated. The structural system of the human body has such a powerful self-health function. Structural information medicine is to mobilize and regulate the structural system, including genes, molecules, cells, tissues and organs, and other subsystems of different levels through structural information of specific structures. Relatively complex, highly ordered, autonomously regulated mechanism of action, which restores the balance of the body’s structure and achieves the purpose of preventing and curing diseases. It not only combines Western medicine’s theory of specific structure and function as the research object, but also integrates traditional Chinese medicine through regulating the body itself. To restore the theory of balance.

(2) Problems solved by structural information medicine

The living body cannot exist independently from the environment. The external structural environment interacts with the body's structural system through structure, that is, matter, energy, and information. Each individual is a unique structural system obtained by the combined action of genes and environment. Structural information medicine emphasizes the internal structure system of biology and its dynamic balance with the external structural environment. It is this dynamic balance that deduces the process of life. In addition to restoring the dynamic balance of the body's own structural system and increasing the body's resistance, structural information medicine focuses on symbiosis and advancement. Symbiosis means that the body no longer blindly resists and defends the external structure, but continuously internalizes the external structure information to achieve the balance between the biological body's structural system and the external structure through the self-adaptation and self-organization functions of the biological body. Turn the enemy into friends, even for my use. Co-progression refers to the structural system of biological organisms obtaining structural characteristics in other biological organisms that are beneficial to biological health, survival and reproduction through structural information. The present invention is based on the established theoretical system of structural information medicine, using the stable structure corresponding to the substance, through the self-adaptation and self-organization of the biological structure system to regulate the expression of its genes or genes, and the treatment is related to the substance Disease.

Summary of the invention

The object of the present invention is to provide a method for designing a substance for treating and/or preventing diseases related to the motor system in view of the above-mentioned defects of the prior art.

Another object of the invention is to provide substances designed according to this method.

Another object of the present invention is to provide a preparation method and application of the substance.

The biological structural system is an organic structural system with uniform stability and adaptability. It can adapt to the environment and maintain the dynamic balance between itself and the external environment, thereby achieving better survival and reproduction of itself. The adaptability of the biological structure system is premised on the stability of the biological structure, which is the dominant structure that plays a key role.

The biological structure system is an organic giant system formed by the spiral development of the core structure composed of concrete structure and abstract structure. The core structure of the biological structure system, that is, the complex of the specific structure and the abstract structure in the nucleic acid-protein structure system, as a genetic information carrier and expression system, plays a dominant role in the function of the biological structure system, and the core structure The dominant structure is the stability structure. At the atomic level, abstract structural DNA and specific structural proteins in the core structure are all biological macromolecules based on carbon as an organic substance. There are 4 electrons in the outermost layer of the carbon atom. It is not easy to lose electrons or get electrons. This structure is conducive to the formation of 4 covalent bonds. The stability of the covalent bond is high, which is the strongest force between organic molecules. The single bond formed mainly by carbon atoms is about 300-500KJ/moL, and the thermal cracking temperature is 500-800℃.

The primary structure of DNA determines the double helix secondary structure of DNA through the effects of base hydrogen bonding and base stacking force. That is, the stable primary structure determines its adaptive secondary structure. The core of genetic information is stable Sexually. DNA transfers genetic information to RNA through transcription, and finally RNA expresses genetic information into protein through translation. This is the rule followed by all cellular organisms. The establishment of the central law clarifies the information transmission path of genetic information from DNA to RNA to protein, from the base sequence in the DNA primary structure to the base sequence in the RNA primary structure to the amino acid sequence in the protein primary structure The genetic information carrier linearly corresponds the information to the amino acids of the functional information carrier through base pairing and triple codons. Therefore, this information transmission path is based on the stability structure of these biological macromolecules, and the stability structure of the abstract structure is transferred to the stability structure of the concrete structure.

The covalent backbone in the primary structure of a protein contains hundreds of single bonds that can rotate freely, but the rigid planar nature of the peptide bonds in the primary structure, the number and position of hydrophilic and hydrophobic amino acids and acid-base amino acids Factors such as these limit the freedom of rotation of each single bond, and ultimately form the most thermodynamically stable three-dimensional structure. Therefore, in fact, the control component of the final structure of the protein, that is, the amino acid sequence was formed very early, these stable structures that dominate the protein conformation form a framework, and the protein is assembled according to this framework during the folding of the polypeptide chain. The final form. The amino acid sequence of a protein contains all the information that determines its three-dimensional structure, and the structure of the protein determines the function of the protein. Therefore, consistent with genetic information, the essence of functional information is that the stability structure determines the adaptive structure.

From a system perspective, the stability of a biological structural system is the self-stabilizing ability of an organic structural system composed of structural interactions. Each structure has a structure that promotes it and a structure that inhibits it. Form a dynamic balance, that is, there will be no lack or too much, and it can self-adjust according to environmental changes within a certain range, so as to maintain and restore the original order state, that is, maintain its own order in an unbalanced state, Among them, the interaction between the stable structures plays a dominant role. For example, in the identification of structural information, the innate immune system in animals and plants can recognize the structural characteristics of pathogens through pattern recognition receptors (PRRs). These characteristics are common to different types of pathogens and are not easily mutated on stable molecular structures (such as all bacteria There are cell walls composed of LPS). Such as food allergies, even if foods containing allergens are cooked at high temperature, they can also cause allergies, and their immune recognition is also a stable structure for identifying allergens. Taking neurotransmitter opioid peptides as an example again, opioid peptides with different stereo conformations have different selectivity for cell membrane receptors. Endorphin-1 is the biologically active peptide with the highest affinity and selectivity for μ receptors known today. The adaptive structure is the molecular basis for the binding of the signal molecule to the receptor, and from the perspective of the changes in its stable structural amino acids, endomorphine-1 differs from other opioid peptides mainly in three amino acids. By changing the amino acid residues, it forms an appropriate spatial layout, changes the three-dimensional spatial conformation, and plays a role of correct positioning for the binding of such transmitters to receptors. The interaction of the stability structure can cause a significant change in the adaptive structure, which plays a huge role in information recognition. In the process of information transmission, the receptors on the cell membrane need to bring information to the nucleus, which mainly depends on the modification of proteins. The basis of protein modification is the chemical reactivity of amino acid residues in the primary structure. Under the action of enzymes, the high-level structure of the protein can be adjusted to the functional requirements of specific space-time conditions by adjusting the stable structure of the protein, with reversibility and versatility , Such as protein phosphorylation and dephosphorylation. The information transmitted to the nucleus, the cell will eventually make corresponding feedback through the change of gene expression, and again pass the instruction through the signal path. Therefore, the stability structure interaction or structural adjustment determines the change of the adaptive structure. Of course, the adaptive structure can also react to the stable structure.

Among the biological structural systems, no structure is "isolated". The interaction, mutual restriction and interdependence between the structures and the sub-structural systems constitute the biological organic structural system. All living things are made up of cells. Cells are the sub-structural systems of the large structural system of the body. According to the complexity of biological organisms, they are composed of hundreds, tens of thousands, or even hundreds of millions of cells that perform various specific functions. Division of labor and cooperation is an orderly and controllable cellular society. This social maintenance not only depends on the material metabolism and energy metabolism of the cell, but also depends on the intercellular communication and signal regulation to coordinate the behavior of the cell, such as the cell. Growth, division, differentiation, apoptosis and other various physiological functions realize the complete life activity process of multicellular organisms. The essence of intercellular communication and signal regulation is also the interaction between structures to determine the behavior and fate of cells, including structural and functional differentiation, location and life-and-death choices. The morphological structure of cells, life activities and their position in the body are regulated and controlled by the body, local tissues, surrounding cells and extracellular signaling molecules, such as nerve cells, immune cells and endocrine cells through social connection, participate and maintain together The body's steady-state balance. The interaction of the structure in the biological structure system allows the cells to distinguish themselves from aliens, and can distinguish between cells of the same species and different species. The mutual recognition and identification of cells, as well as the recognition of oneself and molecules of alien substances, is called cell recognition. On the basis of identification, cells adhere to each other or establish a stable connection with a certain morphological structure, so as to influence and interact with each other. Many important life activities are related to the recognition ability of cells. Cell recognition is also a very important link in the process of cell development and differentiation. Cells form different types of tissues through recognition and adhesion. Body immunity is actually a recognition phenomenon of cells. White blood cells in the blood can recognize invading bacteria and engulf them, but never engulf their own normal cells in the blood. This is cell recognition between different species. When doing allogeneic tissue transplantation clinically, the body will reject the transplanted allogeneic tissue, which is caused by cell recognition between allogeneic cells. In addition, many physiological and pathological processes such as blood coagulation, inflammatory response, thrombosis, pathogenic microbial infection and tumor cell metastasis are related to the complex mutual recognition and adhesion between the same species or different species and the effects induced by them. Structural identification is based on the interactions between structures, which are the basis of adaptive, self-organizing organic structural systems formed by organisms.

The openness of structural systems is not only the opening of specific structures, but also the opening of relationships. The adaptive self-organizing ability of the structural system is mainly reflected in the stability of the system under the stimulation of external environment. The structural system of the body, through the transmission and processing of information, self-adjusts and organizes itself, constantly overcoming the uncertainty of the structural system and keeping it in a dynamic balance. The exchange between the structural system and its environment is not only the exchange of matter, but mainly the exchange of energy or information. To maintain the stability of the internal environment in a constantly changing environment, organisms need the ability of cells to sense these changes and respond. The ability of cells to receive and transmit information and execute instructions is the basis for organisms to respond to changes in internal and external environments. Protein is the executor of various physiological activities in the cell (such as catalyzing chemical reactions and regulating gene expression), and changes in the state of the protein itself will also change its functional state. So organisms use protein molecules owned by cells to build a signaling system. Because the shape of protein molecules can change, the functions closely related to the shape of protein molecules will also change accordingly, and the change of one protein state will change the state of downstream molecules through interaction with downstream protein molecules, and downstream molecules can Changing the state of molecules further downstream, such that the state of the level changes one by one, is the way the information is transmitted in the cell. Moreover, proteins are molecules with biological functions that make a final response to signals after their state changes, becoming effect molecules. The effector molecules at the end of the information transfer chain are mostly transcription factors, which respond to signals by regulating the expression of genes.

Taking the immune system as an example, any external structure entering the body will be recognized and evaluated by the immune system. For example, when bacteria or viruses enter the human body, immune cells interact with foreign structures to recognize their structural information, and then secrete different cytokines according to the structural information to transmit the information to B lymphocytes and regulate the gene expression and synthesis of B cells. IgG antibody, combined with the antigen structure to form a complex, is eventually cleared by macrophages, thus resisting the invasion of foreign objects. When parasitic pathogens invade, immune cells interact with foreign structures. The recognized structural information activates B cells and regulates gene expression to synthesize IgE antibodies. These antibodies bind to mast cells and basophils to release them. Substances such as toxic granule proteins cause the parasite to die.

During this immune response, the identified structure determines the specific feedback effect of the body. Through the interaction with the structure, the specific structure is transformed into an abstract structure-structural information, the body recognizes the structural information, mobilizes multiple cells in the immune system to cooperate, regulate gene expression, and release different active substances to foreign objects. The role of adaptability to achieve a new stable and harmonious structural system. At the same time, the immune system interacts with other systems to exchange material, energy, and information to achieve collaboration between different subsystems in the structural system. This shows that the structural system of the body has structural information recognition and self-regulation, restores the balance of the structural system, and even establishes a new structural balance mechanism with the external structure.

The structure and functions of the human body are very complicated. From the perspective of Western medicine, cells and interstitial cells with similar functions and structures are organically combined to form tissues with specific functions. Various tissues are combined into organs with certain morphological characteristics and physiological functions. The structural characteristics of organs are compatible with their functions. The sum of multiple organs composed of one or several physiological functions is called a system. The whole human body can be divided into 8 systems: sports system, circulatory system, respiratory system, digestive system, urinary system, reproductive system, nervous system and endocrine system. The human body is such a complete unity composed of many organs and systems, and no organ can survive without the whole.

From the perspective of traditional Chinese medicine, the normal health status of the environment inside the human body and the environment outside the human body is harmonious and unified. To put it simply, the human body has five organs, six organs, four limbs and hundreds of skeletons, five senses and nine tips, and skin and muscle veins. These tissues and organs are intricately connected by the strange meridians and eight veins throughout the body. Connection, mutual restraint, coordinated and orderly organic whole. According to the theory of Tibetan elephants, the human body connects the internal organs of the internal organs through the meridian system to form an organic whole. The pathological changes of the internal organs can be reflected by the external organs, the internal organs and the internal organs. Therefore, by observing the external manifestations of the disease, you can understand the location of the disease, distinguish the attributes of the evil and the evil, and grasp the true and false of the qi. The Tibetan elephant theory is a theory that studies the physiological functions, pathological changes and interrelationships of various organs of the human body. The Tibetan finger refers to the internal organs hidden in the body, and the elephant finger refers to the physiological and pathological phenomena manifested outside. Tibetan elephants include various signs of internal organs and their physiological activities and pathological changes. That is to build a larger structural system on the basis of organs and tissues such as organs and tissues such as liver, heart, spleen, lung, and kidney. Five subsystems relative to the overall structural system of the human body.

Lungs and large intestine are associated with genus, which is in the hair, they are filled in the skin, and they are open to the nose; spleen and stomach are connected in the genus, which is in the white lips, they are filled with muscles, and they are open to the mouth; , Qihua is on the face, it is filled with blood veins, and it is open to the tongue; liver and gallbladder are connected, it is in the claw, it is filled with tendons, and it is opened to the eye; In the bone, open the ear and Er Yin.

In response to this organic whole and the five subsystems, the Five Elements doctrine proposes how the multi-dimensional bidirectional adjustment of the internal, external, internal organs, meridians, and other sub-systems of the human body through life, restraint, restraint, and chemistry can achieve the above-mentioned relative balance and coordination of yin and yang. Ordered self-regulation model. The development of neurophysiology, pathology and endocrinology today recognizes the very delicate and important role of neuro-humoral fluids in organisms, and feedback regulation reveals the overall connection of organisms. Traditional Chinese medicine puts the human body in a large system, explores the intersecting relationship between the various levels and factors of the human body from a series of multi-levels, multi-factors, and multi-variables, and recognizes and processes them through corresponding information The relationship between them, and use the steady-state principle of "adjusting yin and yang for a period of peace" to adjust the relationship between them to make them in a more coordinated state of health. Traditional Chinese medicine "syndrome" reflects the nature of the disease, and distinguishes the "syndrome" for treatment. The "syndrome" is neither a disease or symptom mentioned by Western medicine nor a generalization of a single factor or linear causality of the disease. It is based on the uniqueness of traditional Chinese medicine. Theories and methods show the understanding and generalization of the body's reaction state by linking various physiological and pathological factors such as the etiology, disease location, pathogenesis, pathological nature, right and evil, etc. of the disease at a certain stage. It focuses on the unity of opposites of the human body's contradiction between right and evil. Therefore, "supporting the right to eliminate evil" and "relieving the evil to ensure the right", focusing on both the right and the evil, adjusting the yin and yang of the human body, restoring its relative balance, coordinating the steady state of the right and evil is the basic rule of traditional Chinese medicine.

Western medicine studies the relationship between structure and function from a concrete and microscopic perspective. Western medicine studies the relationship between the multi-dimensional and bidirectional adjustment of the human body's functional system from the abstract and macroscopic perspectives. From the structural point of view, the essence of living beings is the dynamic balance, coordinated and orderly adaptive, self-organizing organic structural system formed by the interaction between body structures. Structural information medicine recognizes life from the perspective of structural systems based on the basic theory of structural fusion of Chinese and Western medicine. By allowing the body to recognize the information of specific structures, and using the self-adaptation and self-organization functions of the body structural system, the dynamic balance of the structural system is restored to achieve The purpose of disease prevention. The present invention combines the specific structure of Western medicine research and the macro theory established by traditional Chinese medicine to treat and/or prevent diseases from the perspective of biological systems. Relatively speaking, the system is limited, and the diseases are unlimited, because different diseases of the same organ will produce Different diseases, different individuals have the same symptoms of the same disease, especially when the specific structure of the disease cannot be determined or it is not easy to separate the structure of the disease. The division of traditional Chinese medicine is the same, even between humans, pigs, cattle, sheep, and primates, so the corresponding cells, tissues, or organs that contain this diseased structure (that is, unbalanced structure) are used. Stable structure for disease treatment and/or prevention is more versatile and easier to obtain and prepare. Therefore, according to the system to design the treatment and/or prevention of diseases, for diseases caused by internal disease of the organism, only the specific diseased cells, tissues or organs need to be known, and it is not necessary to explore the mechanism through which the disease is caused and the specific symptoms of the disease The system in which the disease-related substances are located, or the cells, tissues, or organs in the system must be used as the external structure to act on the biological structural system. The biological structural system can make the organism adapt to the structure 、Self-organization to establish a balance with the structure of external substances or restore the internal structural imbalance of the biological structure system, thereby eliminating, alleviating disease, or preventing the occurrence of disease, such as treatment and/or prevention with a stable structure corresponding to pig lung Asthma or diseases on the nose that interact with the structure of the lungs. Allergic rhinitis, which is a disease related to the lungs. The method for designing a substance for treating and/or preventing diseases according to the present invention mainly includes correcting evil with evil and correcting evil with positive:

Lesions that make up the internal structure of the system are often imbalances in structural interactions. For example, for a structure in a biological structure system, the expression of genes that lack the structure that restricts it or the structure that promotes it is lacking. Overexpression of genes will break the balance between structures. For example, tumor suppressor genes and proto-oncogenes restrict each other to maintain the relative stability of positive and negative regulatory signals. When such genes are mutated, deleted or inactivated, they break the balance of the interaction between the structures, which will cause malignant transformation of cells and lead to tumors. In the present invention, the unbalanced structure in the biological structure system is called "inner evil", and the biological structure system is called "positive". The stable structure corresponding to the substance with unbalanced internal structure of the organism disclosed by the present invention acts as an external structure on the structure system of the organism. Due to the functions of adaptation, self-organization and self-stabilization of the biostructure system, the According to the structural information in the external structure, the biological structure system regulates the expression of genes in the structure that interacts with it, so as to achieve a balance with the external structure, thus achieving the restoration of internal imbalances in the biological structure system. The structure is restored to balance and the disease is treated, that is, to support "righteousness" with "inner evil".

Every normal structure in the composition system has a structure that interacts with it, that is, a balanced structure. This application refers to both the balanced structure and the biological structure system as "positive". The stable structure corresponding to the normally non-lesioned substance in the composition system is used as an external structure to act on the biological structure system. Due to the self-organization, self-organization and self-stabilization functions of the biological structure system, the biological structure system According to the structural information of each structure in the external structure, the gene expression of the structure interacting with it is adjusted to a normal level, so the unbalanced structure naturally restores balance. As disclosed in the present invention, the stable structure corresponding to the substance without lesions is used as a substance for treating or preventing diseases caused by lesions of the same or similar substances as the substance without lesions, that is ".

The balance of the biological structure system is dynamic, especially the balance between the biological structure system and the structure of the environment, for example, for substances that can cause disease, but not for a certain organism, then the certain organism The structure of the system and the structure of the disease-causing substance can reach a balance when interacting, that is to say, the structure of a certain organism and the disease has interaction with the structure of the disease-causing substance and The organisms are not allowed to produce the structures of the disease, and these structures are not isolated in the biostructural system, but also exist and interact with each other to form a balance. The stable structure corresponding to the substance related to the disease in the certain organism is used as an external structure to act on the biological structure system that needs to treat the disease, due to the adaptive, self-organizing and Self-stabilization and other functions, the biostructural system will adjust the genes or gene expression of interacting structures according to the structural information of each structure in the external structure, so that the biostructural system and the disease-causing Reaching balance between the structure of matter is also a way to support "positive" with "positive".

Features of the invention:

According to the established theoretical system of structural information medicine, the present invention acts on the biological structural system with the stable structure corresponding to the substance, and adjusts the expression of its genes or genes through the self-adaptation and self-organization capabilities of the biological structural system to treat Diseases related to the substance.

In view of this, the present invention provides a substance for treating and/or preventing diseases related to the sports system, and a design method and a preparation method thereof. The specific solutions are as follows:

A method for designing a substance for treating and/or preventing diseases related to a sports system, using a stable structure corresponding to a substance in the sports system as a substance for treating and/or preventing diseases related to the sports system.

Preferably, the stable structure refers to a structure of a substance that still exists in a solid state after being processed at a high temperature above 500 degrees Celsius.

Preferably, the stable structure corresponding to the substance in the exercise system is selected as one or more of the following substances for treating and/or preventing diseases related to the exercise system:

The stable structure corresponding to the substances in the exercise system includes the stable structure corresponding to all the substances in the exercise system as substances for treating and/or preventing diseases related to the exercise system;

The stable structure corresponding to the substance in the exercise system includes the stable structure corresponding to a certain substance or a combination of certain substances in the exercise system as a substance for treating and/or preventing diseases related to the exercise system;

The stable structure corresponding to the substance constituting the exercise system includes the stable structure corresponding to a certain part or a combination of several parts in the exercise system as a substance for treating and/or preventing diseases related to the exercise system.

In another preferred embodiment, the stable structure corresponding to the substance in the exercise system is selected as one or more of the following substances for treating and/or preventing diseases related to the exercise system:

The stable structure corresponding to the substance in the motionless system without disease is used as a substance for the treatment and/or prevention of diseases caused by the same or similar substances as the substance in the motionless system without disease;

The stable structure corresponding to the substance constituting the lesion in the motor system is used as a substance for treating and/or preventing diseases caused by the same or similar substance as the substance constituting the lesion in the motor system;

The stable structure corresponding to the substance constituting the inhibitory structure of the exercise system disease in the exercise system is used as a substance for treating and/or preventing diseases related to the exercise system.

The substances for treating and/or preventing diseases related to the motor system are designed according to the above method.

Preparation method of the above-mentioned substance for treating and/or preventing diseases related to sports system:

The stable structure corresponding to the substances in the motion system is prepared by high-temperature carbonization.

The use of the above-mentioned substances for treating and/or preventing diseases related to the exercise system in the preparation of medicines, health products, foods, and food additives.

A method for designing a substance for treating and/or preventing bone-related diseases, using a stable structure corresponding to a substance constituting bone or a substance containing bone as a substance for treating and/or preventing bone-related diseases.

Preferably, the substance constituting bone or the stable structure corresponding to the substance containing bone is selected from one or more of the following as a substance for treating and/or preventing diseases related to the bone:

The stable structure corresponding to the bone-constituting substance or bone-containing substance includes the stable structure corresponding to the bone-containing substance as a substance for treating and/or preventing bone-related diseases;

The stable structure corresponding to the bone-constituting substance or bone-containing substance includes the partial stabilizing structure including the bone-constituting substance as a substance for treating and/or preventing bone-related diseases;

The stable structure corresponding to the substance constituting the bone or the substance containing the bone includes the stable structure corresponding to all the substances in the bone as a substance for treating and/or preventing bone-related diseases;

The stable structure corresponding to the bone-constituting substance or bone-containing substance includes a stable structure corresponding to a certain substance or a combination of several substances in the bone as a substance for treating and/or preventing bone-related diseases.

In another preferred aspect, the substance constituting the bone or the stable structure corresponding to the bone-containing substance is selected from one or more of the following as a substance for treating and/or preventing diseases related to the bone:

The stable structure corresponding to the bone-forming substance or bone-containing substance includes the stable structure corresponding to the disease-forming substance in the bone-forming substance or the bone-containing substance as a substance for treating and/or preventing diseases related to the bone ;

The stable structure corresponding to the bone-constituting substance or bone-containing substance includes a bone-constituting substance or bone-containing substance without a lesion as a substance for treating and/or preventing diseases related to the bone;

The stable structure corresponding to the bone-constituting substance or bone-containing substance includes the bone-constituting substance or bone-containing substance containing the stable structure corresponding to the substance that inhibits the bone-related diseases as a treatment and/or prevention and treatment Describe the substance of bone related diseases.

The substances for treating and/or preventing bone-related diseases are designed according to the method described above.

In the above method for preparing a substance for treating and/or preventing bone-related diseases, the stable structure corresponding to the substance constituting bone or the substance containing bone is prepared by a method of high-temperature carbonization.

The application of the above-mentioned substances for treating and/or preventing bone-related diseases in the preparation of medicines, health products, foods and food additives.

A method for designing a substance for treating and/or preventing joint-related diseases, using a stable structure corresponding to a substance constituting a joint or a substance containing a joint as a substance for treating and/or preventing diseases related to the joint.

Preferably, the substance constituting the joint or the stabilizing structure corresponding to the substance containing the joint is selected as one or more of the following substances for treating and/or preventing diseases related to the joint:

The stable structure corresponding to the substance constituting the joint or the substance containing the joint includes the stable structure corresponding to the substance containing the joint as a substance for treating and/or preventing joint-related diseases;

The stable structure corresponding to the substance constituting the joint or the substance containing the joint includes the stable structure corresponding to the substance including part of the joint as a substance for treating and/or preventing joint-related diseases;

The stable structure corresponding to the substance constituting the joint or the substance containing the joint includes the stable structure corresponding to all substances in the joint as a substance for treating and/or preventing joint-related diseases;

The stable structure corresponding to the substance constituting the joint or the substance containing the joint includes a stable structure corresponding to a certain substance or a combination of several substances in the joint as a substance for treating and/or preventing joint-related diseases.

In another preferred aspect, the stable structure corresponding to the substance constituting the joint or the substance containing the joint is selected from one or more of the following as a substance for treating and/or preventing diseases related to the joint:

The stable structure corresponding to the substance constituting the joint or the substance containing the joint includes the stable structure corresponding to the substance constituting the joint or the substance containing the disease as a substance for treating and/or preventing diseases related to the joint ;

The stable structure corresponding to the substance constituting the joint or the substance containing the joint includes a stable structure corresponding to the substance constituting the joint or the substance containing the joint without disease as a substance for treating and/or preventing diseases related to the joint;

The stabilizing structure corresponding to the substance constituting the joint or the substance containing the joint includes the stabilizing structure corresponding to the substance that inhibits the joint-related disease in the substance constituting the joint or the substance containing the joint as a treatment and/or prevention and treatment Describe the substance of joint-related diseases.

The substances for treating and/or preventing joint-related diseases are designed according to the method described above.

In the above method for preparing a substance for treating and/or preventing joint-related diseases, the stable structure corresponding to the substance constituting the joint or the substance containing the joint is prepared by a high-temperature carbonization method.

The use of the aforementioned substances for treating and/or preventing joint-related diseases in the preparation of medicines, health products, foods, and food additives.

A method for designing a substance for treating and/or preventing degenerative osteoarthropathy, using a stable structure corresponding to a substance related to degenerative osteoarthropathy as a substance for treating and/or preventing the degenerative osteoarthropathy.

Preferably, the stable structure corresponding to the substance related to degenerative osteoarthropathy is selected as one or more of the following substances for treating and/or preventing the degenerative osteoarthropathy: the organism itself and degenerative osteoarthropathy Related substances, substances containing structures that inhibit degenerative osteoarthropathy.

In another preferred aspect, the degenerative osteoarthropathy-related substance is derived from a biological movement system.

In another preferred aspect, the degenerative osteoarthropathy-related substance is derived from a substance related to a biological joint, preferably a biological joint.

Degenerative osteoarthropathy, also known as osteoarthritis, degenerative arthritis, and senile arthritis, is a degenerative change that develops with age. It is more common in the middle-aged and elderly people, and it is more likely to occur in weight-bearing joints and joints with more activity. The biological joint contains substances related to degenerative osteoarthropathy and is easily available. Therefore, the stable structure corresponding to the biological joint is preferred as a substance for treating and/or preventing degenerative osteoarthropathy. If other organs or tissues also contain substances related to degenerative osteoarthropathy, it is also preferable to use the stable structure corresponding to the organ or tissue containing degenerative osteoarthropathy as a treatment and/or prevention of degenerative osteoarthropathy Substances, which can simplify complex problems, and can design and prepare substances for the treatment and/or prevention of degenerative osteoarthropathy without knowing the specific lesion structure and pathogenic mechanism. Therefore, the present invention preferably uses the stable structure corresponding to the biological joint as a substance for treating and/or preventing the degenerative osteoarthropathy.

The substances for treating and/or preventing degenerative osteoarthropathy are designed according to the above method.

In the above method for preparing a substance for treating and/or preventing degenerative osteoarthropathy, the stable structure corresponding to the substance related to degenerative osteoarthropathy is prepared by a method of high-temperature carbonization.

The application of the above-mentioned substances for treating and/or preventing degenerative osteoarthropathy in the preparation of medicines, health products, foods and food additives.

A method for designing a substance for treating and/or preventing diseases related to skeletal muscle, using a stable structure corresponding to a substance constituting skeletal muscle or a substance containing skeletal muscle as a treatment and/or prevention of diseases related to skeletal muscle substance.

Preferably, the stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle is selected from one or more of the following substances for treating and/or preventing diseases related to the skeletal muscle:

The stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle includes the stable structure corresponding to the substance containing skeletal muscle as a substance for treating and/or preventing diseases related to skeletal muscle;

The stabilizing structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle includes the stabilizing structure corresponding to the substance comprising part of skeletal muscle as a substance for treating and/or preventing diseases related to skeletal muscle;

The stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle includes the stable structure corresponding to all substances in skeletal muscle as a substance for treating and/or preventing diseases related to skeletal muscle;

The stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle includes the stable structure corresponding to a certain substance or a combination of several substances in skeletal muscle as a substance for treating and/or preventing diseases related to skeletal muscle .

In another preferred aspect, the stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle is selected from one or more of the following substances for treating and/or preventing diseases related to the skeletal muscle:

The stabilizing structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle includes the stabilizing structure corresponding to the diseased substance in the substance constituting skeletal muscle or the substance containing skeletal muscle as a treatment and/or prevention Substances related to diseases;

The stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle includes the stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle without disease as treatment and/or prevention related to the skeletal muscle Substance of the disease;

The stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle includes the substance corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle containing the stable structure corresponding to the substance which inhibits the diseases related to skeletal muscle as a treatment and And/or substances that prevent diseases related to the skeletal muscle.

A substance designed to treat and/or prevent skeletal muscle-related diseases according to the method described above.

In the method for preparing a substance for treating and/or preventing skeletal muscle-related diseases, the stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle is prepared by a high-temperature carbonization method.

The use of the above-mentioned substances for treating and/or preventing skeletal muscle-related diseases in the preparation of medicines, health products, foods, food additives.

A method for designing a substance for treating and/or preventing fibromyalgia syndrome, using a stable structure corresponding to a substance related to fibromyalgia syndrome as a substance for treating and/or preventing the fibromyalgia syndrome.

Preferably, the stable structure corresponding to the substance related to the fibromyalgia syndrome is selected as one or more of the following substances for treating and/or preventing the fibromyalgia syndrome: the organism itself and the fibromyalgia syndrome Related substances, substances containing structures that inhibit fibromyalgia syndrome.

In another preferred embodiment, the substance related to fibromyalgia syndrome is derived from a biological motor system.

Another preferred, the substance related to fibromyalgia syndrome is derived from biological muscle.

Fibromyalgia syndrome is a chronic disease that is difficult to cure. It is a diffuse muscle pain, such as neck cramps, shoulder thoracic muscles such as chest pain, lower back such as back pain, and thigh pain such as thigh and quadriceps Symptoms such as stiffness are more common. Therefore, any fibrous muscle tissue of the organism can be affected, and they are all related to fibromyalgia syndrome.

The obtained substance for treating and/or preventing fibromyalgia syndrome is designed according to the above method.

In the above method for preparing a substance for treating and/or preventing fibromyalgia syndrome, the stable structure corresponding to the substance related to fibromyalgia syndrome is prepared by a high-temperature carbonization method.

The application of the above-mentioned substances for treating and/or preventing fibromyalgia syndrome in the preparation of medicines, health products, foods and food additives.

In the content of the present invention, a stable structure corresponding to a substance is prepared by a high-temperature carbonization method. If the substance is derived from living things, it is preferably a pig, cow, sheep, or primate.

The essence of health is the dynamic balance of the structural system. This dynamic balance is the result of the interaction between the structures in the structural system. The most basic interaction is the promotion and restriction. In a biological structural system, if a structure lacks the structure that promotes it, the structure will be lacking. If it lacks the structure that restricts it, the structure will be too much, which will cause the imbalance of the structural system. The essence of disease is the imbalance of biological structure system. It can be seen from the above technical solutions that the method for treating or preventing diseases disclosed in the present invention is to use the stable structure of the disease-related substance as an external structure to act on a biological structural system (such as oral). Identification and transmission of structural information of external structures, self-adaptation, self-organization and other functions, regulation of gene or gene expression, treatment or prevention of diseases related to the substance.

As can be seen from the above technical solutions, the substances for treating and/or preventing diseases disclosed in the present invention and the design methods and preparation methods thereof, the beneficial effects include:

1. The design method and preparation method of the substance for treating and/or preventing diseases of the present invention, the emphasis is not on the specific structure of the substance causing the disease, nor the specific mechanism of the disease, but on the use of the same external substances or substances in the body that cause the disease or The stable structure corresponding to the similar substance acts as an external structure on the biological structure system. The external structure can make the organism adapt to the structure and self-organize to eliminate, alleviate the disease, or prevent the occurrence of the disease, so it is versatile.

2. The present invention combines the specific structure of Western medicine research and the macro theory established by traditional Chinese medicine to treat and/or prevent disease from the perspective of a biological system. Relatively speaking, the system is limited, and the disease is unlimited, because the same organ has different lesions. Different diseases will occur, and the symptoms of the same disease will not be the same among different individuals. From a systematic point of view, whether people are divided according to Western medicine or Chinese medicine, even people and pigs, cattle, sheep and primates Creatures are basically the same. Therefore, according to the system to design the treatment and/or prevention of diseases, for diseases caused by internal disease of the organism, only the specific diseased cells, tissues or organs need to be known, and it is not necessary to explore the mechanism through which the disease is caused and the specific symptoms of the disease. The system in which the disease-related substances are located, or the cells, tissues, or organs in the system must be used as the external structure to act on the biological structural system. The biological structural system can make the organism adapt to the structure 1. Self-organization to establish balance with the structure of external substances or restore the internal structural imbalance of the biological structure system, thereby eliminating, alleviating disease, or preventing the occurrence of disease.

3. The substance for treating and/or preventing diseases of the present invention and its design method and preparation method avoid the research on the disease mechanism and greatly save the investment of time, manpower, material resources and financial resources. It greatly reduces the cost of treatment of periodic diseases in drug development, and is the ultimate simplification of drug development, disease diagnosis, and treatment.

detailed description

The invention discloses a substance for treating and/or preventing diseases of sports system, and a design method and a preparation method thereof. Those skilled in the art can refer to the content of this article, can use different substances, can improve the process implementation or other similar process preparation, and they are all considered to be included in the present invention. In particular, it should be noted that all similar substitutions and modifications are obvious to those skilled in the art, and they are all considered to be included in the present invention. The methods and products of the present invention have been described through preferred embodiments, and it is obvious that relevant persons can modify or appropriately modify and combine the methods described herein without departing from the content, spirit, and scope of the present invention to implement and apply this method. Invention technology.

In order to further understand the present invention, the technical solutions in the embodiments of the present invention will be described clearly and completely in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, but not all the embodiments . Based on the embodiments of the present invention, all other embodiments obtained by a person of ordinary skill in the art without making creative efforts fall within the protection scope of the present invention.

The specific implementation method is as follows:

Example 1: A substance for treating and/or preventing degenerative osteoarthropathy and its design method and preparation method

Degenerative osteoarthropathy, also known as osteoarthritis, degenerative arthritis, and senile arthritis, is a degenerative change that develops with age. It is more common in the middle-aged and elderly people, and it is more likely to occur in weight-bearing joints and joints with more activity. The biological joint contains substances related to degenerative osteoarthropathy and is easily available. Therefore, the stable structure corresponding to the biological joint is preferred as a substance for treating and/or preventing degenerative osteoarthropathy. If other organs or tissues also contain substances related to degenerative osteoarthropathy, it is also preferable to use the stable structure corresponding to the organ or tissue containing degenerative osteoarthropathy as a treatment and/or prevention of degenerative osteoarthropathy Substances, which can simplify complex problems, and can design and prepare substances for the treatment and/or prevention of degenerative osteoarthropathy without knowing the specific lesion structure and pathogenic mechanism. Therefore, in this embodiment, the bovine joints are selected to obtain substances for treating and/or preventing degenerative osteoarthropathy by means of high-temperature carbonization.

Example 2: The clinical application test of the substance prepared in Example 1 for the treatment of degenerative osteoarthropathy

The present invention uses the substance prepared in the above Example 1 to verify the efficacy, and the specific cases are as follows:

1. Clinical data: A total of 17 patients with degenerative osteoarthropathy were collected in the present invention, including 4 males and 13 females, aged 42-59 years.

2. Diagnostic criteria: refer to the 1994 "Diagnostic Criteria for Traumatology and Traumatology Disorders of Traditional Chinese Medicine", and exclude degenerative osteoarthropathy caused by non-osseous joint disease.

3. Treatment method: The substance for treating degenerative bone and joint prepared in Example 1 was orally administered 3g/time, once/day, for 7 days of continuous treatment, and followed up for 6 months.

4. Evaluation standard of curative effect: The marked effect is that the patient's joint movement after treatment is not subject to any restrictions, and clinical symptoms such as pain and discomfort all disappear. It is effective for the patient's pain situation to improve after treatment, joint movement limitation is reduced, discomfort and pain have been improved. Inefficiency is that after treatment, the patient's clinical symptoms such as pain and discomfort have not improved, and the condition has even worsened, which has a serious impact on daily life. Total efficiency = significant efficiency + efficiency.

5. Treatment results: According to 6 months of follow-up, the efficacy was observed. Among the 17 cases, 11 were markedly effective, 5 were effective, and 1 was ineffective. The total effective rate was 94.12%.

Claims

A method of designing a substance for treatment and/or prevention of diseases related to the motor system, characterized by:

Use the stable structure corresponding to the substance in the exercise system as a substance to treat and/or prevent diseases related to the exercise system;

The stable structure is characterized by the structure of the substance that still exists in a solid state after being processed at a high temperature above 500 degrees Celsius.
The method according to claim 1, wherein the stable structure corresponding to the substance in the exercise system is selected from one or more of the following as a substance for treating and/or preventing diseases related to the exercise system :

The stable structure corresponding to the substances in the exercise system includes the stable structure corresponding to all the substances in the exercise system as substances for treating and/or preventing diseases related to the exercise system;

The stable structure corresponding to the substance in the exercise system includes the stable structure corresponding to a certain substance or a combination of certain substances in the exercise system as a substance for treating and/or preventing diseases related to the exercise system;

The stable structure corresponding to the substance constituting the exercise system includes the stable structure corresponding to a certain part or a combination of several parts in the exercise system as a substance for treating and/or preventing diseases related to the exercise system.
The method according to claim 1, wherein the stable structure corresponding to the substance in the exercise system as a substance for treating and/or preventing diseases related to the exercise system includes:

The stable structure corresponding to the substance in the non-lesion-forming kinematic system is used as a substance for treating and/or preventing diseases caused by lesions of the same or similar substances as those in the non-lesion-forming kinematic system.
The method according to claim 1, wherein the stable structure corresponding to the substance in the exercise system as a substance for treating and/or preventing diseases related to the exercise system includes:

The stable structure corresponding to the substance constituting the lesion in the motor system is used as a substance for treating and/or preventing diseases caused by the same or similar substance as the substance constituting the lesion in the motor system.
The method according to claim 1, wherein the stable structure corresponding to the substance in the exercise system as a substance for treating and/or preventing diseases related to the exercise system includes:

The stable structure corresponding to the substance constituting the inhibitory structure of the exercise system disease in the exercise system is used as a substance for treating and/or preventing diseases related to the exercise system.
The substance designed to treat and/or prevent diseases related to the motor system according to the method of any one of claims 1-5.
The method for preparing a substance for treating and/or preventing diseases related to a motor system according to claim 6, characterized in that:

The stable structure corresponding to the substances in the motion system is prepared by high-temperature carbonization.
A method for designing a substance for treating and/or preventing bone-related diseases, characterized by:

Using the bone-constituting substance or the stable structure corresponding to the bone-containing substance as a substance for treating and/or preventing diseases related to the bone;

The stable structure corresponding to the substance is characterized by the structure of the substance that still exists in a solid state after being processed at a high temperature above 500 degrees Celsius.
The method according to claim 8, characterized in that the substance constituting bone or the stable structure corresponding to the substance containing bone is selected from the following one as a substance for treating and/or preventing diseases related to the bone or Several:

The stable structure corresponding to the bone-constituting substance or bone-containing substance includes the stable structure corresponding to the bone-containing substance as a substance for treating and/or preventing bone-related diseases;

The stable structure corresponding to the bone-constituting substance or bone-containing substance includes the partial stabilizing structure including the bone-constituting substance as a substance for treating and/or preventing bone-related diseases;

The stable structure corresponding to the substance constituting the bone or the substance containing the bone includes the stable structure corresponding to all the substances in the bone as a substance for treating and/or preventing bone-related diseases;

The stable structure corresponding to the bone-constituting substance or bone-containing substance includes a stable structure corresponding to a certain substance or a combination of several substances in the bone as a substance for treating and/or preventing bone-related diseases.
The method according to claim 8, characterized in that the substance constituting bone or the stable structure corresponding to the substance containing bone is selected from the following one as a substance for treating and/or preventing diseases related to the bone or Several:

The stable structure corresponding to the bone-forming substance or bone-containing substance includes the stable structure corresponding to the disease-forming substance in the bone-forming substance or the bone-containing substance as a substance for treating and/or preventing diseases related to the bone ;

The stable structure corresponding to the bone-constituting substance or bone-containing substance includes a bone-constituting substance or bone-containing substance without a lesion as a substance for treating and/or preventing diseases related to the bone;

The stable structure corresponding to the bone-constituting substance or bone-containing substance includes the bone-constituting substance or bone-containing substance containing the stable structure corresponding to the substance that inhibits the bone-related diseases as a treatment and/or prevention and treatment Describe the substance of bone related diseases.
A substance designed to treat and/or prevent bone-related diseases according to the method of any one of claims 8-10.
The method for preparing a substance for treating and/or preventing bone-related diseases according to claim 11, characterized in that:

The stable structure corresponding to the bone-constituting substance or the bone-containing substance is prepared by a high-temperature carbonization method.
A method for designing a substance for treating and/or preventing joint-related diseases, characterized by:

Using the substance constituting the joint or the stable structure corresponding to the substance containing the joint as a substance for treating and/or preventing diseases related to the joint;

The stable structure corresponding to the substance is characterized by the structure of the substance that still exists in a solid state after being processed at a high temperature above 500 degrees Celsius.
The method according to claim 13, wherein the substance constituting the joint or the stabilizing structure corresponding to the substance containing the joint is selected from the following one as a substance for treating and/or preventing diseases related to the joint Several:

The stable structure corresponding to the substance constituting the joint or the substance containing the joint includes the stable structure corresponding to the substance containing the joint as a substance for treating and/or preventing joint-related diseases;

The stable structure corresponding to the substance constituting the joint or the substance containing the joint includes the stable structure corresponding to the substance including part of the joint as a substance for treating and/or preventing joint-related diseases;

The stable structure corresponding to the substance constituting the joint or the substance containing the joint includes the stable structure corresponding to all substances in the joint as a substance for treating and/or preventing joint-related diseases;

The stable structure corresponding to the substance constituting the joint or the substance containing the joint includes a stable structure corresponding to a certain substance or a combination of several substances in the joint as a substance for treating and/or preventing joint-related diseases.
The method according to claim 13, wherein the substance constituting the joint or the stabilizing structure corresponding to the substance containing the joint is selected from the following one as a substance for treating and/or preventing diseases related to the joint Several:

The stable structure corresponding to the substance constituting the joint or the substance containing the joint includes the stable structure corresponding to the substance constituting the joint or the substance containing the disease as a substance for treating and/or preventing diseases related to the joint ;

The stable structure corresponding to the substance constituting the joint or the substance containing the joint includes a stable structure corresponding to the substance constituting the joint or the substance containing the joint without disease as a substance for treating and/or preventing diseases related to the joint;

The stabilizing structure corresponding to the substance constituting the joint or the substance containing the joint includes the stabilizing structure corresponding to the substance that inhibits the joint-related disease in the substance constituting the joint or the substance containing the joint as a treatment and/or prevention and treatment Describe the substance of joint-related diseases.
A substance designed to treat and/or prevent joint-related diseases according to the method of any one of claims 13-15.
The method for preparing a substance for treating and/or preventing joint-related diseases according to claim 16, characterized in that:

The stable structure corresponding to the substance constituting the joint or the substance containing the joint is prepared by a high-temperature carbonization method.
A method for designing a substance for treating and/or preventing degenerative osteoarthropathy, characterized by:

Using a stable structure corresponding to a substance related to degenerative osteoarthropathy as a substance for treating and/or preventing the degenerative osteoarthropathy;

The stable structure corresponding to the substance is characterized by the structure of the substance that still exists in a solid state after being processed at a high temperature above 500 degrees Celsius.
The method according to claim 18, characterized in that the stable structure corresponding to the substance related to degenerative osteoarthropathy is selected from one or more of the following as a substance for treating and/or preventing the degenerative osteoarthropathy Species: Substances related to degenerative osteoarthropathy and substances containing structures that inhibit degenerative osteoarthropathy.
The method according to claim 18, wherein the substance related to degenerative osteoarthropathy is derived from a biological movement system.
The method according to claim 18, wherein the degenerative osteoarthropathy-related substance is derived from a biological joint-related substance, preferably a biological joint.
A substance designed to treat and/or prevent degenerative osteoarthropathy according to the method of any one of claims 18-21.
The method for preparing a substance for treating and/or preventing degenerative osteoarthropathy according to claim 22, characterized in that:

The stable structure corresponding to the substance related to degenerative osteoarthropathy is prepared by a high-temperature carbonization method.
A method for designing a substance for treating and/or preventing skeletal muscle-related diseases, characterized by:

Using a substance constituting skeletal muscle or a stable structure corresponding to a substance containing skeletal muscle as a substance for treating and/or preventing diseases related to the skeletal muscle;

The stable structure corresponding to the substance is characterized by the structure of the substance that still exists in a solid state after being processed at a high temperature above 500 degrees Celsius.
The method according to claim 24, wherein the stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle is selected as the substance for treating and/or preventing diseases related to the skeletal muscle One or more types:

The stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle includes the stable structure corresponding to the substance containing skeletal muscle as a substance for treating and/or preventing diseases related to skeletal muscle;

The stabilizing structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle includes the stabilizing structure corresponding to the substance comprising part of skeletal muscle as a substance for treating and/or preventing diseases related to skeletal muscle;

The stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle includes the stable structure corresponding to all substances in skeletal muscle as a substance for treating and/or preventing diseases related to skeletal muscle;

The stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle includes the stable structure corresponding to a certain substance or a combination of several substances in skeletal muscle as a substance for treating and/or preventing diseases related to skeletal muscle .
The method according to claim 24, wherein the stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle is selected from the following substances for treating and/or preventing diseases related to the skeletal muscle One or more types:

The stabilizing structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle includes the stabilizing structure corresponding to the diseased substance in the substance constituting skeletal muscle or the substance containing skeletal muscle as a treatment and/or prevention Substances related to diseases;

The stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle includes the stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle without disease as treatment and/or prevention related to the skeletal muscle Substance of the disease;

The stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle includes the substance corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle containing the stable structure corresponding to the substance which inhibits the diseases related to skeletal muscle as a treatment and And/or substances that prevent diseases related to the skeletal muscle.
A substance designed to treat and/or prevent skeletal muscle-related diseases according to the method of any one of claims 24-26.
The method for preparing a substance for treating and/or preventing skeletal muscle-related diseases according to claim 27, characterized in that:

The stable structure corresponding to the substance constituting skeletal muscle or the substance containing skeletal muscle is prepared by a high-temperature carbonization method.
A method for designing a substance for treatment and/or prevention of fibromyalgia syndrome, characterized by:

Using the stable structure corresponding to the substance related to fibromyalgia syndrome as a substance for treating and/or preventing the fibromyalgia syndrome;

The stable structure corresponding to the substance is characterized by the structure of the substance that still exists in a solid state after being processed at a high temperature above 500 degrees Celsius.
The method according to claim 29, wherein the stable structure corresponding to the substance related to fibromyalgia syndrome is selected from one or more of the following as a substance for treating and/or preventing the fibromyalgia syndrome Species: Substances related to fibromyalgia syndrome, substances containing structures that inhibit fibromyalgia syndrome.
The method according to claim 29, wherein the substance related to fibromyalgia syndrome is derived from a biological motor system.
The method according to claim 29, wherein the substance related to fibromyalgia syndrome is derived from biological muscle.
A substance designed to treat and/or prevent fibromyalgia syndrome according to the method of any one of claims 29-32.
The method for preparing a substance for treating and/or preventing fibromyalgia syndrome according to claim 33, characterized in that:

The stable structure corresponding to the substance related to fibromyalgia syndrome is prepared by a high-temperature carbonization method.
Use of the substance according to any one of claims 6, 11, 16, 22, 27, 33 in the preparation of medicines, health products, foods, food additives.