WO2020107206A1 - Traditional chinese medicine composition, and preparation process therefor and use thereof - Google Patents

Traditional chinese medicine composition, and preparation process therefor and use thereof Download PDF

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WO2020107206A1
WO2020107206A1 PCT/CN2018/117653 CN2018117653W WO2020107206A1 WO 2020107206 A1 WO2020107206 A1 WO 2020107206A1 CN 2018117653 W CN2018117653 W CN 2018117653W WO 2020107206 A1 WO2020107206 A1 WO 2020107206A1
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parts
chinese medicine
traditional chinese
medicine composition
pinellia
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PCT/CN2018/117653
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French (fr)
Chinese (zh)
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刘志杰
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深圳市得道健康管理有限公司
刘志杰
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Priority to PCT/CN2018/117653 priority Critical patent/WO2020107206A1/en
Priority to CN201880028342.0A priority patent/CN111491646A/en
Publication of WO2020107206A1 publication Critical patent/WO2020107206A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888Pinellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system

Definitions

  • the invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine composition and its preparation process and application.
  • the human back can be divided into three areas from top to bottom: upper coke, middle coke and lower coke, where upper coke includes heart and lung, middle coke includes spleen and stomach, lower coke includes liver and kidney, upper coke fire, lower coke cold Common symptoms are summarized according to this. Usually, the hot symptoms of dizziness, sore throat and other upper parts are called scorching fire. The weak spleen and kidney lead to insufficient blood and dysfunction, and insufficient blood and blood can not support liver blood.
  • Deficiency and yin deficiency lead to yang sheng, so liver fire is strong, resulting in scorching fire, and due to weak spleen and kidney, spleen blood deficiency, qi and blood mutualization, so blood deficiency causes qi deficiency, qi deficiency is Qi dysfunction, Can not warm the scorch to cause scorch cold.
  • the technical problem to be solved by the present invention is how to propose a Chinese medicine composition that can effectively relieve the symptoms described in the background art, and its preparation process and application.
  • the technical solutions of the present invention are:
  • the present invention provides a traditional Chinese medicine composition.
  • the composition consists of 30-150 parts of Qianhu, 10-50 parts of ginseng, 10-50 parts of ginger, 15-75 parts of yellow cens, and 15-45 parts of roast, by weight.
  • Licorice 20-100 parts jujube, 20-130 parts pinellia.
  • the composition consists of 35-60 parts of Qianhu, 10-25 parts of ginseng, 10-25 parts of ginger, 15-30 parts of yellow cens, 15-20 parts of licorice root, 24-50 parts Jujube, 20-50 parts Pinellia composition.
  • the composition consists of 65-90 parts of Qianhu, 30-40 parts of ginseng, 30-40 parts of ginger, 35-50 parts of yellow cens, 25-30 parts of licorice root, 52-64 parts by weight Jujube, consisting of 55-75 parts Pinellia.
  • the composition consists of 95-145 parts of Qianhu, 42-48 parts of ginseng, 42-48 parts of ginger, 55-70 parts of yellow cens, 32-40 parts of licorice root, and 70-96 parts by weight.
  • Jujube, 80-125 parts Pinellia composition is preferably used.
  • the composition consists of 120 parts of Qianhu, 45 parts of ginseng, 45 parts of ginger, 45 parts of yellow cens, 30 parts of licorice root, 48 parts of jujube, and 130 parts of pinellia in parts by weight.
  • the invention also provides a process for preparing the traditional Chinese medicine composition, which comprises the following steps:
  • the medicine residue is filtered to obtain the medicine juice.
  • the mass ratio of pinellia to water is 1:18.5-120, the soaking time is 50-80min, and the boiling time is 20-40min.
  • the boiling temperature is 100-115°C, and the boiling time is 90-120min.
  • the amount of medicinal juice obtained in step S3 is 3/16-1/4 of the amount of water.
  • the invention also provides the application of the traditional Chinese medicine composition in the preparation of yin and yang, anti-stress and debilitating drugs.
  • the traditional Chinese medicine composition according to the present invention is composed of 30-150 parts of Qianhu, 10-50 parts of ginseng, 10-50 parts of ginger, 15-75 parts of yellow cens, and 15-45 parts of roast in terms of parts by weight.
  • Patients treated with the above composition have scorching depression and scorching cold; stagnation of drinking water and stagnation of drinking water cause the heart to be upset, and patients often have symptoms of relief and ease, so paeonia can not be used to prevent paeonia from aggravating The patient's condition.
  • Qianhu has the effects of lowering gas and reducing phlegm, dispersing wind and clearing heat.
  • FIG. 1 is a process flow diagram of preparing the traditional Chinese medicine composition according to an embodiment of the present invention.
  • This embodiment provides a traditional Chinese medicine composition, which can be used to alleviate upper scorching heat, lower scorch deficiency cold, drinking water upside down, drinking water stagnation and heat, upset, uncomfortable, lowering the stool and dizziness, dryness of the throat , Nausea, dysphagia, fullness of mind, ruffling pain, cold and heat, cold pain in the abdomen and other symptoms.
  • the traditional Chinese medicine composition is composed of 30 g of Qianhu, 50 g of ginseng, 10 g of ginger, 75 g of yellow cens, 15 g of licorice root, 100 g (25 pieces) of jujube and 20 g of pinellia.
  • This embodiment also provides a process for preparing the Chinese medicine composition, which includes the following steps:
  • Qianhu has the effects of dispersing wind and clearing heat, lowering qi and reducing phlegm, and can be used for phlegm and heat, fullness of phlegm, thickening of phlegm, cough and phlegm of wind and heat;
  • ginseng has the enzyme activity of increasing liver metabolism of various substances, making the liver The detoxification ability of the body is enhanced, thereby enhancing the body's tolerance to various chemical substances, supplementing the five internal organs, calming the spirit, calming the soul, stopping the palpitations, removing evil spirits, bright eyes happy puzzle and other effects; ginger has divergence, vomiting, cough, etc.
  • Huang Cen has the effects of clearing away heat and dampness, purging fire and detoxifying. It is mainly used for treating fever, upper respiratory tract infection, lung heat cough, damp heat yellow gallbladder, pneumonia, dysentery, hemoptysis, red eyes, fetal restlessness, hypertension, carbuncle.
  • Boils and embolism licorice root has the effects of nourishing qi and nourishing yin, and Tongyang rejuvenating the pulse;
  • jujube has the effects of nourishing the spleen and stomach, replenishing qi and replenishing qi, replenishing qi and qi, removing boredom, nourishing blood and liver;
  • Pinellia has dryness
  • the functions of dampening phlegm, reducing antrum and reducing vomiting, and eliminating boils for health use are prepared by decoction.
  • the medicinal effects of each component cooperate with each other to produce a synergistic effect.
  • the traditional Chinese medicine composition can be used for preparing medicines for reconciling yin and yang, reducing adverse effects and removing pimples.
  • This embodiment provides a traditional Chinese medicine composition, which is composed of 150 g of Qianhu, 10 g of ginseng, 50 g of ginger, 15 g of yellow cens, 45 g of roasted licorice, 20 g (5 pieces) of jujube, and 130 g of Pinellia.
  • This embodiment also provides a process for preparing the Chinese medicine composition, which includes the following steps:
  • the traditional Chinese medicine composition can be used for preparing medicines for reconciling yin and yang, reducing adverse effects and removing pimples.
  • the traditional Chinese medicine composition consists of 120 g of Qianhu, 45 g of ginseng, 45 g of ginger, 45 g of yellow cens, 30 g of licorice root, 48 g (12 pieces) of jujube and 130 g of pinellia by weight. composition.
  • This embodiment also provides a process for preparing the Chinese medicine composition, which includes the following steps:
  • the traditional Chinese medicine composition can be used for preparing medicines for reconciling yin and yang, reducing adverse effects and removing pimples.
  • Examples 4-12 provide the traditional Chinese medicine compositions in the ratios shown in Table 1, and the preparation process of the traditional Chinese medicine compositions in each ratio is the same as that in Examples 1-3.
  • a total of 97 patients with cold, heat, and abdominal pain caused by evil invaders were selected from the decade of 2008 to 2018. Of the 97 patients, 45 were male and 52 were female, with ages ranging from 6-50 years old. Symptoms are caused by cold and hot exchanges, abdominal pain, and dizziness of the head, dryness of the throat, vomiting, inability to eat, full of heart and chest pain, swollen pain, cold and heat, cold pains in the abdomen, lower profits, etc.
  • Treatment method The traditional Chinese medicine composition prepared by the invention is taken three times in the morning, middle and evening, 200ml each time for one week.
  • Criteria for curative effect cure: the symptoms and signs disappear completely; marked effect: most of the symptoms and signs disappear after treatment; ineffective: the symptoms and signs have not been alleviated or even aggravated.
  • Curative effect statistics 97 patients treated with the combination of traditional Chinese medicine according to the present invention, 73 cases cured, 15 cases markedly effective, 9 cases ineffective, and the effective rate can reach 90.7%. Chinese medicinal composition for removing guilt.

Abstract

Disclosed are a traditional Chinese medicine composition, a preparation process therefor and the use of the composition in the preparation of a drug for regulating Yin and Yang, calming adverse-rising energy and eliminating pain. The traditional Chinese medicine composition is composed of 30-150 parts of Peucedani radix, 10-50 parts of Ginseng radix et rhizoma, 10-50 parts of Zingiberis rhizoma recens, 15-75 parts of Scutellariae radix, 15-45 parts of Glycyrrhizae radix et rhizoma praeparata cum melle, 20-100 parts of Jujubae fructus, and 20-130 parts of Pinelliae rhizoma.

Description

一种中药组合物及其制备工艺与应用Chinese medicine composition and its preparation process and application 技术领域Technical field
本发明属于中药技术领域,具体地说涉及一种中药组合物及其制备工艺与应用。The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine composition and its preparation process and application.
背景技术Background technique
从中医学角度,人体后背可由上至下划分为三个区:上焦、中焦和下焦,其中,上焦包括心肺、中焦包括脾胃、下焦包括肝肾,上焦火、下焦寒这种常见症状就是依此划分总结而来。通常,头昏、咽喉肿痛等偏上部位的火热症状称之为上焦火,脾肾虚弱导致气血不足而运行不畅,气血不足又导致无法供养肝血,肝血不足则为阴虚,阴虚导致阳盛,所以肝火旺盛,从而产生上焦火的现象,又由于脾肾虚弱,脾脏生血虚,气血互化,所以血虚引起气虚,气虚则气万养的功能失调,不能温暖下焦导致下焦虚寒。From the perspective of Chinese medicine, the human back can be divided into three areas from top to bottom: upper coke, middle coke and lower coke, where upper coke includes heart and lung, middle coke includes spleen and stomach, lower coke includes liver and kidney, upper coke fire, lower coke cold Common symptoms are summarized according to this. Usually, the hot symptoms of dizziness, sore throat and other upper parts are called scorching fire. The weak spleen and kidney lead to insufficient blood and dysfunction, and insufficient blood and blood can not support liver blood. Deficiency and yin deficiency lead to yang sheng, so liver fire is strong, resulting in scorching fire, and due to weak spleen and kidney, spleen blood deficiency, qi and blood mutualization, so blood deficiency causes qi deficiency, qi deficiency is Qi dysfunction, Can not warm the scorch to cause scorch cold.
上焦火下焦寒从中医角度来讲是心肾不交引起的,心在中医属于阳,肾属于阴,正常的情况下,心里的阳气下行到下焦来中和肾的阴气,肾的阴气上升到上焦来中和心的阳气,这样阴阳平衡,人体处于健康的状态,而心肾不交,则出现下焦阴气过多,出现怕冷,上焦火气较旺,出现上焦郁热、下焦虚寒、水饮上逆、水饮郁热互结、心烦不舒、下利便溏等症状,具体表现为头晕目眩、咽干、易呕、食不下、心胸烦闷、痞痛、往来寒热、腹中冷痛等,对于上述症状,目前尚无药效良好的中药配方。Upper scorching fire and lower scorching cold are caused by heart-kidney disagreement from the perspective of Chinese medicine. The heart belongs to yang in Chinese medicine, and the kidney belongs to yin. Under normal circumstances, the yang in the heart descends to the lower coke to neutralize the yin of the kidney. The yin qi rises to the upper coke to neutralize the yang of the heart, so that the yin and yang balance, the human body is in a healthy state, and the heart and kidney do not intersect, there is too much yin qi under the coke, there is fear of cold, the scorching anger is more vigorous, the upper Symptoms such as scorching heat, scorching cold, drinking water upside down, drinking water and stagnation of heat, upset, and diarrhea. The specific manifestations are dizziness, dry throat, vomiting, lack of food, anxiety, ruffling pain, contacts Cold and heat, cold pain in the abdomen, etc. For the above symptoms, there is currently no effective Chinese medicine formula.
发明内容Summary of the invention
为此,本发明所要解决的技术问题在于如何提出一种可有效缓解背景技术中所述症状的中药组合物及其制备工艺与应用。To this end, the technical problem to be solved by the present invention is how to propose a Chinese medicine composition that can effectively relieve the symptoms described in the background art, and its preparation process and application.
为解决上述技术问题,本发明的技术方案为:To solve the above technical problems, the technical solutions of the present invention are:
本发明提供一种中药组合物,以重量份计,所述组合物由30-150份前胡、10-50份人参、10-50份生姜、15-75份黄岑、15-45份炙甘草、20-100份大枣、20-130份半夏组成。The present invention provides a traditional Chinese medicine composition. The composition consists of 30-150 parts of Qianhu, 10-50 parts of ginseng, 10-50 parts of ginger, 15-75 parts of yellow cens, and 15-45 parts of roast, by weight. Licorice, 20-100 parts jujube, 20-130 parts pinellia.
作为优选,以重量份计,所述组合物由35-60份前胡、10-25份人参、10-25份生姜、15-30份黄岑、15-20份炙甘草、24-50份大枣、20-50份半夏组成。Preferably, in terms of parts by weight, the composition consists of 35-60 parts of Qianhu, 10-25 parts of ginseng, 10-25 parts of ginger, 15-30 parts of yellow cens, 15-20 parts of licorice root, 24-50 parts Jujube, 20-50 parts Pinellia composition.
作为优选,以重量份计,所述组合物由65-90份前胡、30-40份人参、30-40份生姜、35-50份黄岑、25-30份炙甘草、52-64份大枣、55-75份半夏组成。Preferably, the composition consists of 65-90 parts of Qianhu, 30-40 parts of ginseng, 30-40 parts of ginger, 35-50 parts of yellow cens, 25-30 parts of licorice root, 52-64 parts by weight Jujube, consisting of 55-75 parts Pinellia.
作为优选,以重量份计,所述组合物由95-145份前胡、42-48份人参、42-48份生姜、55-70份黄岑、32-40份炙甘草、70-96份大枣、80-125份半夏组成。Preferably, the composition consists of 95-145 parts of Qianhu, 42-48 parts of ginseng, 42-48 parts of ginger, 55-70 parts of yellow cens, 32-40 parts of licorice root, and 70-96 parts by weight. Jujube, 80-125 parts Pinellia composition.
作为优选,以重量份计,所述组合物由120份前胡、45份人参、45份生姜、45份黄岑、30份炙甘草、48份大枣、130份半夏组成。Preferably, the composition consists of 120 parts of Qianhu, 45 parts of ginseng, 45 parts of ginger, 45 parts of yellow cens, 30 parts of licorice root, 48 parts of jujube, and 130 parts of pinellia in parts by weight.
本发明还提供一种制备所述的中药组合物的工艺,其包括如下步骤:The invention also provides a process for preparing the traditional Chinese medicine composition, which comprises the following steps:
S1、将半夏用水浸泡后第一次煎煮;S1, the first decoction after soaking Pinellia in water;
S2、第一次煎煮结束后按比例加入前胡、人参、生姜、黄岑、炙甘草和大枣,第二次煎煮;S2. After the first frying, add Qianhu, ginseng, ginger, yellow cens, roasted licorice and jujube in proportion to the second frying;
S3、第二次煎煮结束后过滤药渣得到药汁。S3. After the second decoction, the medicine residue is filtered to obtain the medicine juice.
作为优选,所述步骤S1中,所述半夏与水的质量比为1∶18.5-120,浸泡时间为50-80min,煎煮时间为20-40min。Preferably, in the step S1, the mass ratio of pinellia to water is 1:18.5-120, the soaking time is 50-80min, and the boiling time is 20-40min.
作为优选,所述步骤S2中,煎煮的温度为100-115℃,煎煮时间为90-120min。Preferably, in the step S2, the boiling temperature is 100-115°C, and the boiling time is 90-120min.
作为优选,所述步骤S3得到的药汁的量为水量的3/16-1/4。Preferably, the amount of medicinal juice obtained in step S3 is 3/16-1/4 of the amount of water.
本发明还提供一种所述的中药组合物在制备调和阴阳、降逆除痞药物中的应用。The invention also provides the application of the traditional Chinese medicine composition in the preparation of yin and yang, anti-stress and debilitating drugs.
本发明的上述技术方案相比现有技术具有以下优点:Compared with the prior art, the above technical solution of the present invention has the following advantages:
本发明所述的中药组合物,以重量份计,所述组合物由30-150份前胡、 10-50份人参、10-50份生姜、15-75份黄岑、15-45份炙甘草、20-100份大枣、20-130份半夏组成。上述组合物治疗的病人上焦郁热、下焦虚寒;水饮上逆、水饮郁热互结心中,所以导致心烦不舒,而病人往往有下利便溏的症状,所以不能使用芍药,防止芍药加重患者下利的病情。且组合物中,前胡具有降气化痰、散风清热的功效,与柴胡相比,具有更强的推陈出新、清泄热邪、疏解半表里不畅的功效,临床疗效更佳。上述组分按照“君、臣、佐、使”的配伍关系相互配合,协同作用,有效缓解了病人上焦郁热、下焦虚寒、水饮上逆、水饮郁热互结、心烦不舒、下利便溏、头晕目眩、咽干、易呕、食不下、心胸烦闷、痞痛、往来寒热、腹中冷痛等症状。The traditional Chinese medicine composition according to the present invention is composed of 30-150 parts of Qianhu, 10-50 parts of ginseng, 10-50 parts of ginger, 15-75 parts of yellow cens, and 15-45 parts of roast in terms of parts by weight. Licorice, 20-100 parts jujube, 20-130 parts pinellia. Patients treated with the above composition have scorching depression and scorching cold; stagnation of drinking water and stagnation of drinking water cause the heart to be upset, and patients often have symptoms of relief and ease, so paeonia can not be used to prevent paeonia from aggravating The patient's condition. Moreover, in the composition, Qianhu has the effects of lowering gas and reducing phlegm, dispersing wind and clearing heat. Compared with Bupleurum, it has a stronger effect of innovating, clearing away heat and evil, and relieving unsatisfactory appearance. The clinical effect is better. The above components cooperate with each other according to the compatibility relationship of "Jun, Chen, Zuo, Shi", and synergistic effect, effectively alleviate the patient's scorching heat, scorching cold, water drink on the reverse, water drink stagnation of heat and heat, upset, down Convenient for diarrhea, dizziness, dry throat, nausea, dysphagia, anxiety in the chest, ruffling pain, cold heat, cold pain in the abdomen and other symptoms.
附图说明BRIEF DESCRIPTION
为了使本发明的内容更容易被清楚的理解,下面根据本发明的具体实施例并结合附图,对本发明作进一步详细的说明,其中In order to make the content of the present invention easier to understand clearly, the present invention will be further described in detail based on specific embodiments of the present invention and the accompanying drawings, in which
图1是本发明实施例所述的制备所述中药组合物的工艺流程图。FIG. 1 is a process flow diagram of preparing the traditional Chinese medicine composition according to an embodiment of the present invention.
具体实施方式detailed description
实施例1Example 1
本实施例提供一种中药组合物,所述中药组合物可用于缓解上焦郁热、下焦虚寒、水饮上逆、水饮郁热互结、心烦不舒、下利便溏以及头目眩晕、咽干、易呕、食不下、心胸烦满、痞痛、往来寒热、腹中冷痛等症状。This embodiment provides a traditional Chinese medicine composition, which can be used to alleviate upper scorching heat, lower scorch deficiency cold, drinking water upside down, drinking water stagnation and heat, upset, uncomfortable, lowering the stool and dizziness, dryness of the throat , Nausea, dysphagia, fullness of mind, ruffling pain, cold and heat, cold pain in the abdomen and other symptoms.
所述中药组合物由30g前胡、50g人参、10g生姜、75g黄岑、15g炙甘草、100g(25枚)大枣和20g半夏组成。The traditional Chinese medicine composition is composed of 30 g of Qianhu, 50 g of ginseng, 10 g of ginger, 75 g of yellow cens, 15 g of licorice root, 100 g (25 pieces) of jujube and 20 g of pinellia.
本实施例还提供一种制备该中药组合物的工艺,其包括如下步骤:This embodiment also provides a process for preparing the Chinese medicine composition, which includes the following steps:
S1、将半夏用120倍质量的水(2400ml)在煎药罐中浸泡50min,然后大火煮开后换小火,第一次煎煮40min。S1. Immerse Pinellia with 120 times the quality of water (2400ml) in the decoction pot for 50min, then boil it on high heat and then change it to low heat, boil for 40min for the first time.
S2、第一次煎煮后,按照上述配比,加入剩余组分:前胡、人参、生姜、黄岑、炙甘草和大枣,保持100℃的加热温度第二次煎煮120min。S2. After the first frying, add the remaining components: Qianhu, ginseng, ginger, yellow cens, licorice root and jujube according to the above ratio, and maintain the heating temperature of 100°C for the second frying for 120 min.
S3、关火冷却,用纱布过滤分离药渣与药液,得到加入水量1/4(600ml) 的药液。S3. Turn off the fire and cool, filter and separate the medicine residue and the medicine liquid with gauze to obtain the medicine liquid with 1/4 (600ml) of added water.
上述组合物中,前胡具有散风清热,降气化痰的功效,可用于痰热喘满、咯痰黄稠、风热咳嗽痰多;人参具有增加肝脏代谢各物质的酶活性,使肝脏的解毒能力增强,从而增强机体对各种化学物质的耐受力、补五脏、安精神、定魂魄、止惊悸、除邪气、明目开心益智等功效;生姜具有发散、止呕、止咳等功效;黄岑具有清热燥湿、泻火解毒等功效,主治温热病、上呼吸道感染、肺热咳嗽、湿热黄胆、肺炎、痢疾、咳血、目赤、胎动不安、高血压、痈肿疖疮等症;炙甘草具有有益气滋阴,通阳复脉的功效;大枣具有补脾和胃、益气生津、补中益气、除烦闷、养血补肝等功效;半夏具有燥湿化痰、降逆止呕、生用消疖肿作用,上述组分经煎煮制备,各组分的药效相互配合,产生了协同增效的作用。In the above composition, Qianhu has the effects of dispersing wind and clearing heat, lowering qi and reducing phlegm, and can be used for phlegm and heat, fullness of phlegm, thickening of phlegm, cough and phlegm of wind and heat; ginseng has the enzyme activity of increasing liver metabolism of various substances, making the liver The detoxification ability of the body is enhanced, thereby enhancing the body's tolerance to various chemical substances, supplementing the five internal organs, calming the spirit, calming the soul, stopping the palpitations, removing evil spirits, bright eyes happy puzzle and other effects; ginger has divergence, vomiting, cough, etc. Efficacy; Huang Cen has the effects of clearing away heat and dampness, purging fire and detoxifying. It is mainly used for treating fever, upper respiratory tract infection, lung heat cough, damp heat yellow gallbladder, pneumonia, dysentery, hemoptysis, red eyes, fetal restlessness, hypertension, carbuncle. Boils and embolism; licorice root has the effects of nourishing qi and nourishing yin, and Tongyang rejuvenating the pulse; jujube has the effects of nourishing the spleen and stomach, replenishing qi and replenishing qi, replenishing qi and qi, removing boredom, nourishing blood and liver; Pinellia has dryness The functions of dampening phlegm, reducing antrum and reducing vomiting, and eliminating boils for health use are prepared by decoction. The medicinal effects of each component cooperate with each other to produce a synergistic effect.
所述中药组合物可用于制备调和阴阳、降逆除痞的药物。The traditional Chinese medicine composition can be used for preparing medicines for reconciling yin and yang, reducing adverse effects and removing pimples.
实施例2Example 2
本实施例提供一种中药组合物,所述中药组合物由150g前胡、10g人参、50g生姜、15g黄岑、45g炙甘草、20g(5枚)大枣和130g半夏组成。This embodiment provides a traditional Chinese medicine composition, which is composed of 150 g of Qianhu, 10 g of ginseng, 50 g of ginger, 15 g of yellow cens, 45 g of roasted licorice, 20 g (5 pieces) of jujube, and 130 g of Pinellia.
本实施例还提供一种制备该中药组合物的工艺,其包括如下步骤:This embodiment also provides a process for preparing the Chinese medicine composition, which includes the following steps:
S1、将半夏用18.5倍质量的水(2405ml)在煎药罐中浸泡80min,然后大火煮开后换小火,第一次煎煮20min。S1. Immerse Pinellia with 18.5 times the quality of water (2405ml) in the decoction pot for 80 minutes, then boil it on high heat and then change it to low heat, decoction for the first time for 20 minutes.
S2、第一次煎煮后,按照上述配比,加入剩余组分:前胡、人参、生姜、黄岑、炙甘草和大枣,保持115℃的加热温度第二次煎煮120min。S2. After the first frying, add the remaining components according to the above ratio: Qianhu, ginseng, ginger, yellow cens, licorice and jujube, and maintain the heating temperature of 115°C for 120min for the second frying.
S3、关火冷却,用纱布过滤分离药渣与药液,得到加入水量3/16(450.1ml)的药液。S3. Turn off the fire and cool, filter and separate the medicine residue and the medicine liquid with gauze to obtain the medicine liquid with the added water amount of 3/16 (450.1ml).
所述的中药组合物可用于制备调和阴阳、降逆除痞的药物。The traditional Chinese medicine composition can be used for preparing medicines for reconciling yin and yang, reducing adverse effects and removing pimples.
实施例3Example 3
本实施例提供一种中药组合物,以重量份计,所述中药组合物由120g前胡、45g人参、45g生姜、45g黄岑、30g炙甘草、48g(12枚)大枣和130g 半夏组成。This example provides a traditional Chinese medicine composition. The traditional Chinese medicine composition consists of 120 g of Qianhu, 45 g of ginseng, 45 g of ginger, 45 g of yellow cens, 30 g of licorice root, 48 g (12 pieces) of jujube and 130 g of pinellia by weight. composition.
本实施例还提供一种制备该中药组合物的工艺,其包括如下步骤:This embodiment also provides a process for preparing the Chinese medicine composition, which includes the following steps:
S1、将半夏用24.6倍质量的水(3200ml)在煎药罐中浸泡60min,然后大火煮开后换小火,第一次煎煮30min。S1, soak Pinellia with 24.6 times the quality of water (3200ml) in the decoction pot for 60min, then boil it on high heat and change to low heat, decoction for the first time for 30min.
S2、第一次煎煮后,按照上述重量份的配比,加入剩余组分:前胡、人参、生姜、黄岑、炙甘草和大枣,保持105℃的加热温度第二次煎煮110min。S2. After the first frying, add the remaining components: Qianhu, ginseng, ginger, yellow cens, roasted licorice and jujube according to the proportion of the above parts by weight, and maintain the heating temperature of 105℃ for the second frying for 110min .
S3、关火冷却,用纱布过滤分离药渣与药液,得到加入水量7/32(700ml)的药液。S3. Turn off the fire and cool, filter and separate the medicine residue and medicine liquid with gauze to obtain the medicine liquid with the added water amount of 7/32 (700ml).
所述的中药组合物可用于制备调和阴阳、降逆除痞的药物。The traditional Chinese medicine composition can be used for preparing medicines for reconciling yin and yang, reducing adverse effects and removing pimples.
实施例4-12Example 4-12
实施例4-12提供如表1所示配比的中药组合物,各配比下的中药组合物制备工艺与实施例1-3相同。Examples 4-12 provide the traditional Chinese medicine compositions in the ratios shown in Table 1, and the preparation process of the traditional Chinese medicine compositions in each ratio is the same as that in Examples 1-3.
表1Table 1
Figure PCTCN2018117653-appb-000001
Figure PCTCN2018117653-appb-000001
Figure PCTCN2018117653-appb-000002
Figure PCTCN2018117653-appb-000002
实验例Experimental example
选取2008年-2018年十年间97名由邪侵体而导致的寒热往来、腹痛的患者,97个患者中,男性45例、女性52例,年龄分布在6-50岁之间,所有患者的症状均为由外邪侵体而导致的寒热往来、腹痛,以及头目眩晕,咽干,易呕,食不下,心胸烦满、痞痛,往来寒热,腹中冷痛、下利等。A total of 97 patients with cold, heat, and abdominal pain caused by evil invaders were selected from the decade of 2008 to 2018. Of the 97 patients, 45 were male and 52 were female, with ages ranging from 6-50 years old. Symptoms are caused by cold and hot exchanges, abdominal pain, and dizziness of the head, dryness of the throat, vomiting, inability to eat, full of heart and chest pain, swollen pain, cold and heat, cold pains in the abdomen, lower profits, etc.
治疗方式:采用本发明所制得的中药组合物,分早中晚三次服用,每次服用200ml,服用一周。Treatment method: The traditional Chinese medicine composition prepared by the invention is taken three times in the morning, middle and evening, 200ml each time for one week.
疗效判断标准:治愈:症状和体征完全消失;显效:治疗后大部分的症状和体征消失;无效:症状和体征没有得到缓解甚至有加重的趋势。Criteria for curative effect: cure: the symptoms and signs disappear completely; marked effect: most of the symptoms and signs disappear after treatment; ineffective: the symptoms and signs have not been alleviated or even aggravated.
疗效统计:采用本发明所述的中药组合治疗后的97例病患,治愈73例、显效15例、无效9例,有效率可达90.7%,是一种药效良好的调和阴阳、 降逆除痞的中药组合物。Curative effect statistics: 97 patients treated with the combination of traditional Chinese medicine according to the present invention, 73 cases cured, 15 cases markedly effective, 9 cases ineffective, and the effective rate can reach 90.7%. Chinese medicinal composition for removing guilt.
显然,上述实施例仅仅是为清楚地说明所作的举例,而并非对实施方式的限定。对于所属领域的普通技术人员来说,在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无需也无法对所有的实施方式予以穷举。而由此所引伸出的显而易见的变化或变动仍处于本发明创造的保护范围之中。Obviously, the above examples are only examples for clear explanation, and are not limitations on the implementation. For those of ordinary skill in the art, other different forms of changes or changes can be made based on the above description. There is no need to exhaustively list all implementations. The obvious changes or changes derived from this are still within the protection scope created by the present invention.

Claims (10)

  1. 一种中药组合物,其特征在于,以重量份计,所述组合物由30-150份前胡、10-50份人参、10-50份生姜、15-75份黄岑、15-45份炙甘草、20-100份大枣、20-130份半夏组成。A traditional Chinese medicine composition, characterized in that the composition consists of 30-150 parts of Qianhu, 10-50 parts of ginseng, 10-50 parts of ginger, 15-75 parts of yellow cens, 15-45 parts by weight It consists of roasted licorice, 20-100 parts of jujube and 20-130 parts of pinellia.
  2. 根据权利要求1所述的中药组合物,其特征在于,以重量份计,所述组合物由35-60份前胡、10-25份人参、10-25份生姜、15-30份黄岑、15-20份炙甘草、24-50份大枣、25-50份半夏组成。The traditional Chinese medicine composition according to claim 1, characterized in that, based on parts by weight, the composition is composed of 35-60 parts of Qianhu, 10-25 parts of ginseng, 10-25 parts of ginger, 15-30 parts of yellow cen , 15-20 parts licorice, 24-50 parts jujube, 25-50 parts Pinellia.
  3. 根据权利要求1所述的中药组合物,其特征在于,以重量份计,所述组合物由65-90份前胡、30-40份人参、30-40份生姜、35-50份黄岑、25-30份炙甘草、52-64份大枣、55-75份半夏组成。The traditional Chinese medicine composition according to claim 1, characterized in that, based on parts by weight, the composition is composed of 65-90 parts of Qianhu, 30-40 parts of ginseng, 30-40 parts of ginger, 35-50 parts of yellow cen , 25-30 parts licorice, 52-64 parts jujube, 55-75 parts Pinellia.
  4. 根据权利要求1所述的中药组合物,其特征在于,以重量份计,所述组合物由95-145份前胡、42-48份人参、42-48份生姜、55-70份黄岑、32-40份炙甘草、70-96份大枣、80-125份半夏组成。The traditional Chinese medicine composition according to claim 1, characterized in that, based on parts by weight, the composition is composed of 95-145 parts of Qianhu, 42-48 parts of ginseng, 42-48 parts of ginger, 55-70 parts of yellow cen , 32-40 parts of licorice, 70-96 parts of jujube, 80-125 parts of Pinellia.
  5. 根据权利要求1所述的中药组合物,其特征在于,以重量份计,所述组合物由120份前胡、45份人参、45份生姜、45份黄岑、30份炙甘草、48份大枣、130份半夏组成。The traditional Chinese medicine composition according to claim 1, characterized in that the composition consists of 120 parts of Qianhu, 45 parts of ginseng, 45 parts of ginger, 45 parts of yellow cens, 30 parts of licorice root, 48 parts by weight Jujube, 130 Pinellia composition.
  6. 一种制备如权利要求1-5任一项所述的中药组合物的工艺,其特征在于,包括如下步骤:A process for preparing the Chinese medicine composition according to any one of claims 1-5, characterized in that it comprises the following steps:
    S1、将半夏用水浸泡后第一次煎煮;S1, the first decoction after soaking Pinellia in water;
    S2、第一次煎煮结束后按比例加入前胡、人参、生姜、黄岑、炙甘草和大枣,进行第二次煎煮;S2. After the first frying, add Qianhu, ginseng, ginger, yellow cens, roasted licorice and jujube in proportion for the second frying;
    S3、第二次煎煮结束后过滤药渣得到药汁。S3. After the second decoction, the medicine residue is filtered to obtain the medicine juice.
  7. 根据权利要求6所述的中药组合物的制备工艺,其特征在于,所述步骤S1中,所述半夏与水的质量比为1∶18.5-120,浸泡时间为50-80min,煎煮时间为20-40min。The preparation process of the traditional Chinese medicine composition according to claim 6, characterized in that, in the step S1, the mass ratio of pinellia to water is 1:18.5-120, the soaking time is 50-80min, the decoction time 20-40min.
  8. 根据权利要求7所述的中药组合物的制备工艺,其特征在于,所述步骤S2中,煎煮的温度为100-115℃,煎煮时间为90-120min。The preparation process of the traditional Chinese medicine composition according to claim 7, characterized in that in step S2, the decoction temperature is 100-115°C and the decoction time is 90-120min.
  9. 根据权利要求8所述的中药组合物的制备工艺,其特征在于,所述步骤S3得到的药汁的量为水量的3/16-1/4。The preparation process of the traditional Chinese medicine composition according to claim 8, characterized in that the amount of medicinal juice obtained in step S3 is 3/16-1/4 of the amount of water.
  10. 一种如权利要求1-5任一项所述的中药组合物在制备调和阴阳、降逆除痞药物中的应用。The use of the traditional Chinese medicine composition according to any one of claims 1 to 5 in the preparation of a medicine for reconciling Yin and Yang and lowering the pimple.
PCT/CN2018/117653 2018-11-27 2018-11-27 Traditional chinese medicine composition, and preparation process therefor and use thereof WO2020107206A1 (en)

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