WO2020097726A1 - Procédé de fabrication d'huile de vapotage comprenant un cannabinoïde destiné à être utilisé dans un dispositif de vapotage - Google Patents

Procédé de fabrication d'huile de vapotage comprenant un cannabinoïde destiné à être utilisé dans un dispositif de vapotage Download PDF

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Publication number
WO2020097726A1
WO2020097726A1 PCT/CA2019/051618 CA2019051618W WO2020097726A1 WO 2020097726 A1 WO2020097726 A1 WO 2020097726A1 CA 2019051618 W CA2019051618 W CA 2019051618W WO 2020097726 A1 WO2020097726 A1 WO 2020097726A1
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WO
WIPO (PCT)
Prior art keywords
vape
cannabinoid
oil
viscosity
additive
Prior art date
Application number
PCT/CA2019/051618
Other languages
English (en)
Inventor
Max Alsayar
Patrick Woods
Original Assignee
Hexo Operations Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA3024052A external-priority patent/CA3024052A1/fr
Priority claimed from CA3024431A external-priority patent/CA3024431C/fr
Priority claimed from CA3024645A external-priority patent/CA3024645A1/fr
Application filed by Hexo Operations Inc. filed Critical Hexo Operations Inc.
Priority to EP19884098.5A priority Critical patent/EP3880184A4/fr
Priority to CA3119204A priority patent/CA3119204A1/fr
Publication of WO2020097726A1 publication Critical patent/WO2020097726A1/fr
Priority to US16/898,129 priority patent/US20200297025A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A24B15/302—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by natural substances obtained from animals or plants
    • A24B15/303—Plant extracts other than tobacco
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/10—Devices using liquid inhalable precursors
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A24F40/42—Cartridges or containers for inhalable precursors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes

Definitions

  • This application generally relates to the field of manufacturing vape oil including a cannabinoid for use in a vape device.
  • electronic vape devices utilize a liquid supply reservoir that contains a liquid material.
  • the liquid material is drawn toward a heater via a wick, where the heater vaporizes the liquid material, and the vaporized liquid is entrained in an air flow that is discharged into a vaper’s mouth for consumption and ultimately for a desired physiological effect.
  • the liquid material In order for the liquid material to properly operate in the vape device, the liquid material must have properties, which are suitable for the liquid to vaporize, namely the liquid must have a proper viscosity such that it can be adequately metered to the heating element by the capillary action of the wick. For instance, a liquid that is too viscous will not function well because the wick will have difficulty transferring the liquid to the heating element.
  • viscosity requirement for proper operation of the vape device is an important factor that currently limits the effectiveness of vape oils in the recreational or medicinal vaping cannabis industry.
  • viscosity of the active ingredient (i.e., cannabinoid) source material is typically high due to the inherent physicochemical properties of the source material components, and as such, one must dilute the cannabinoid source material in a proper solvent (e.g., carrier oils, polyethylene glycol, etc.), often in large proportions in order to obtain a viscosity which is suitable for proper operation of the vape device.
  • a proper solvent e.g., carrier oils, polyethylene glycol, etc.
  • a number of liquid material formulations have been proposed for use in vape devices, in particular in connection with the nicotine market (e-cigarettes).
  • nicotine market e-cigarettes
  • such formulations are not easily transferrable into other markets, such as the cannabis vaping market.
  • thinning agent is required for cannabis concentrates, which typically have a viscosity which is too high for use in vape devices
  • common thinning agents used in the nicotine market have been reported as negatively affecting the organoleptic properties of cannabis concentrates and/or causing serious health issues.
  • vape oils including a cannabinoid for use in a vape device is not an issue in other forms of cannabis consumption, such as ingestible oils, where viscosity is not a key factor for the cannabis oil formulation.
  • viscosity is not a key factor for the cannabis oil formulation.
  • the oil can be made more viscous to increase the cannabinoid concentration, which from the perspective of oral ingestion is not a problem.
  • vape oils including a cannabinoid when the vape oils including a cannabinoid is vaporized and inhaled, the user experience is different and the cannabinoid concentration matters to achieve the desired physical effect, which the user typically correlates to a number of puffs. Users generally desire to obtain a quick effect with the minimum number of puffs; hence vape oil with a high cannabinoid concentration is desired.
  • the present disclosure relates to a method of manufacturing vape oil including a cannabinoid, the vape oil having a viscosity at room temperature suitable for use in a vape device, the method comprising: (a) selecting a cannabinoid source including a cannabinoid, the cannabinoid having a vaporization temperature, the cannabinoid source having a viscosity at room temperature which is above the viscosity at room temperature suitable for use in the vape device and having a flash point above the vaporization temperature; (b) selecting an additive having a viscosity below the vape oil viscosity and having a flash point below the vaporization temperature, the additive operating to lower the viscosity of the cannabinoid source and operating to
  • the present disclosure relates to a method of manufacturing vape oil including a cannabinoid, the vape oil having a viscosity at room temperature suitable for use in a vape device, the method comprising: (a) selecting a cannabinoid source including the cannabinoid, the cannabinoid having a vaporization temperature, the cannabinoid source having a viscosity at room temperature which is above the viscosity at room temperature suitable for use in the vape device and having a flash point above the vaporization temperature; (b) selecting a terpene having a viscosity below the viscosity at room temperature suitable for use in the vape device and having a flash point below the vaporization temperature, the terpene operating to lower the viscosity of the cannabinoid source and operating to lower a flash point of a mixture of the cannabinoid source and the terpene; (c) determining a concentration of ter
  • the present disclosure relates to a method for manufacturing a vape cartridge for a vape device, the method comprising: a) providing a vape cartridge including: (i) an unfilled reservoir for receiving a vape oil containing a cannabinoid characterized by a vaporization temperature; (ii) vaporization means configured to achieve vaporization of the cannabinoid wherein the vape oil supplied to the vaporization means has a viscosity at room temperature that does not exceed a predetermined viscosity threshold; (b) formulating vape oil according to the viscosity threshold such that the vape oil is suitable for use in the vape cartridge, the formulating including: (i) selecting a cannabinoid source including the cannabinoid, the cannabinoid source having a viscosity at room temperature which is above the viscosity threshold; (ii) selecting an additive having a viscosity below the viscosity threshold and having a flash point
  • the present disclosure relates to a method for manufacturing a vape cartridge for vaping vape oil containing a cannabinoid, the method comprising: a) selecting a cannabinoid to vape in a range of cannabinoids that can be vaped, the selected cannabinoid being characterized by a vaporization temperature, b) providing the vape cartridge including: (i) an unfilled liquid reservoir configured to be filled with vape oil containing the cannabinoid; (ii) vaporization means configured to achieve vaporization of the cannabinoid when the vape oil supplied to the vaporization means has a viscosity at room temperature that does not exceed a predetermined threshold viscosity; c) formulating the vape oil according to the viscosity threshold such that the vape oil is suitable for use in the vape cartridge, the formulating including: (i) selecting a cannabinoid source including the selected cannabinoid, the cannabinoi
  • the present disclosure relates to a method of manufacturing vape oil including a cannabinoid, the vape oil having a viscosity at room temperature suitable for use in a vaping device, the method comprising: a) selecting a cannabinoid source including the cannabinoid, the cannabinoid having a vaporization temperature, the cannabinoid source having a viscosity at room temperature which is above the viscosity at room temperature suitable for use in a vaping device, and having a flash point above the vaporization temperature; b) selecting an additive having a viscosity below the viscosity at room temperature suitable for use in a vaping device and having a flash point below the vaporization temperature, the additive operating to lower the viscosity of the cannabinoid source and operating to lower a flash point of a mixture of the cannabinoid source and additive; c) determining a range of concentrations of additive that (i) will reduce
  • the present disclosure relates to a method of manufacturing vape oil including a cannabinoid, the vape oil having a viscosity at room temperature suitable for use in a vape device, the method comprising: (a) selecting a cannabinoid source including a cannabinoid, the cannabinoid having a vaporization temperature, the cannabinoid source having a viscosity at room temperature which is above the viscosity at room temperature suitable for use in the vape device and having a flash point above the vaporization temperature; (b) selecting an additive having a viscosity below the vape oil viscosity and having a flash point below the vaporization temperature, the additive operating to lower the viscosity of the cannabinoid source and operating to lower a flash point of a mixture of the cannabinoid source and the additive; (c) mixing the cannabinoid source of a) and the additive of b) in proportions such that the
  • the present disclosure relates to a method of manufacturing vape oil including a cannabinoid, where the vape oil is advantageously free of conventional thinning agents, such as for example Vitamin E, medium chain triglycerides (MCT), Vegetable Glycerin (VG), Polyethylene Glycol (PEG), and Propylene Glycol (PG).
  • conventional thinning agents such as for example Vitamin E, medium chain triglycerides (MCT), Vegetable Glycerin (VG), Polyethylene Glycol (PEG), and Propylene Glycol (PG).
  • the herein described methods may have one or more of the following features, in any possible combination:
  • the vaporization means includes a ceramic core
  • vape oil includes cannabidiol (CBD);
  • vape oil includes 3 400 mg/ml of CBD, 3 550 mg/ml of CBD, 3 650 mg/ml of
  • vape oil includes tetrahydrocannabinol (THC);
  • vape oil includes 3 400 mg/ml of THC, 3 550 mg/ml of THC, 3 650 mg/ml of
  • vape oil includes £ 30 mg/ml THC
  • the cannabinoid source is in a proportion of 3 40 wt.% relative to total weight of the vape oil
  • the additive is an oil of plant origin
  • the method further comprises incorporating a volume of the vape oil into a reservoir of a vape cartridge or a vape pen;
  • the vape cartridge includes a connector at one end thereof to engage with a battery compartment of a vape device;
  • the vape cartridge or vape pen comprises a ceramic core for vaporizing the vape oil
  • vape oil includes more than one cannabinoid
  • vape oil includes more than one terpene.
  • FIG. 1 is a plan view of a cartridge component of an electronic vape device in accordance with an embodiment of the present disclosure
  • Fig. 2 is an isometric view of a battery compartment component of an electronic vape device in accordance with an embodiment of the present disclosure
  • FIG. 3 is an isometric view of a vape device in accordance with an embodiment of the present disclosure
  • Fig. 4 is an isometric view of an example vape device tank including a ceramic core in accordance with an embodiment of the present disclosure
  • Fig. 5 is a flowchart illustrating a process for manufacturing a vape oil including a cannabinoid in accordance with an embodiment of the present disclosure
  • FIG. 6 is a flowchart illustrating a process for manufacturing a vape oil including a cannabinoid in accordance with an embodiment of the present disclosure
  • FIG. 7 is a flowchart illustrating a step of the process of Fig. 5 and Fig. 6 in accordance with an embodiment of the present disclosure.
  • vape oil is manufactured while taking into account the vape device operating parameters and the vape oil constituent physicochemical properties in order to obtain a vape oil with suitable viscosity and flash point, as is further described in the specification.
  • the vape oil is free of PEG, VG, PG, MCT and/ or Vitamin E.
  • vape oil [032] Generally speaking, several options exist to obtain the herein described vape oil. [033] In one broad non-limiting practical implementation, one can dilute a cannabinoid source having a viscosity at room temperature which is above the vape device operating viscosity threshold to the point of obtaining a desired viscosity below the vape device operating viscosity threshold. Dilution of the cannabinoid source is performed with an additive, where the additive operates to reduce the viscosity of a mixture of the cannabinoid source and the additive. In particular, the additive is characterized as having a flash point which is below the vape device operating vaporization temperature.
  • the vape device operating vaporization temperature is typically configured to provide sufficient energy to vaporize the cannabinoid present in the vape oil so as to provide the desired user experience after at least one puff event.
  • the proportions of cannabinoid source and additive being mixed is selected such that the mixture has a viscosity below the vape device operating viscosity threshold while maintaining a flash point above the vaporization temperature.
  • Dilution of the first and second cannabinoid sources is performed with an additive to the point of obtaining a desired viscosity below the vape device operating viscosity threshold.
  • the additive operates to reduce the viscosity of a mixture of the first and second cannabinoid sources and the additive.
  • the additive is characterized as having a flash point which is below the vape device operating vaporization temperature.
  • the vape device operating vaporization temperature is typically configured to provide sufficient energy to vaporize the cannabinoid present in the vape oil so as to provide the desired user experience after at least one puff event.
  • the proportions of the first and second cannabinoid sources and additive being mixed is selected such that the mixture has a viscosity below the vape device operating viscosity threshold while maintaining a flash point above the vaporization temperature.
  • the first cannabinoid source may include a CBD distillate oil and the second cannabinoid source may include a THC distillate oil.
  • first cannabinoid source to second cannabinoid source thus impacts on the overall viscosity of the mixture thereof, which then also impacts how much additive is required to dilute to the point of obtaining a desired viscosity for the vape oil which is below the vape device operating viscosity threshold.
  • the cannabinoid source is characterized with a viscosity at room temperature which is above the vape device operating viscosity threshold and thus requires dilution to the point of obtaining a desired viscosity below the vape device operating viscosity threshold.
  • PEG, MCT, VG, PG and Vitamin E as thinning agent
  • the additive is characterized as having a flash point which is below the vape device operating vaporization temperature.
  • the vape device operating vaporization temperature is typically configured to provide sufficient energy to vaporize the cannabinoid present in the vape oil profile so as to provide the desired user experience after at least one puff event.
  • the proportions of cannabinoid source and additive being mixed is selected such that the mixture has a viscosity below the vape device operating viscosity threshold while maintaining a flash point above the vaporization temperature.
  • the herein described methods may further include filling a liquid reservoir of a vape cartridge or vape pen with the vape oil.
  • the person of skill will readily realize that the step of filling the liquid reservoir may be performed by the same person formulating the vape oil or may be performed by another individual, for example. In the latter case, the method of the present disclosure may include a further step of releasing the vape oil such that another individual receiving the vape oil can proceed to fill the liquid reservoir with the vape oil.
  • the present disclosure relates to a method for making a cannabis-based vaping oil which is safe to use in a vaping device.
  • the vaping oil presents a low risk of ignition when it is vaporized by the heating element of the vaping device.
  • vaping oil is heated in a vaping device above the flash point of the mixture, it becomes ignitable, hence not safe to use. In those conditions, a malfunction of the vaping device can cause the vaping oil to catch fire and bum the user.
  • the flash point of a mixture is determined by the flash point of the individual ingredients that make up the mixture.
  • the additives used V G, PEG or PG
  • V G, PEG or PG have much higher flash points than the temperature at which nicotine vaporizes. Accordingly, nicotine-based vaping oils do not present a safety risk, irrespective of the respective proportions of the constituents.
  • Cannabis-based vaping oils provide a vast palette of desirable composition options in terms of taste and physiological and/or psychoactive effect on the user, but that variability also creates a lack of consistency in the potential for ignition. Hence some compositions which may have beneficial effects in terms of user experience, may actually not be safe to use in a vaping device.
  • the present application teaches that one of the implications of using such additives (i.e., having a flash point below the vaporization temperature of the cannabinoid) is that, if too much of it is used, it will operate to reduce the overall flash point of the vape oil to below the vaporization temperature of the cannabinoid contained in the vape oil. Accordingly, when the vape oil is used in a vape device, in which it is heated at or above the vaporization temperature of the cannabinoid contained in the vape oil, the flash point of the vape oil will be exceeded, which presents a safety risk due to combustion risk.
  • the technical challenge faced by the inventors was how to balance a desired composition of vape oil containing a cannabinoid which achieves a desired user experience such as taste (provided by a particular additive) and a desired physiological and/or psychotic effect (provided by a particular cannabinoid) with user safety, i.e., low risk of sustained combustion and the absence of thinning agents that may represent a health risk.
  • the additive includes a compound which operates to lower the viscosity of a mixture of the cannabinoid source and the additive, and has a flash point which is below the vaporization temperature of the cannabinoid in the cannabis concentrate.
  • Examples of additives that are typically used with nicotine-containing or THC- containing vape oils have a flash point above the vaporization temperature include Vitamin E, Vegetable Glycerin (VG), Polyethylene Glycol (PEG), and Propylene Glycol (PG). Objectively, those compounds are not desirable because they are suspected to potentially produce toxic and carcinogenic impurities as a result of the thermal decomposition when vaporizing the vape oil. For example, on September 6, 2019, the FDA issued a Safety Information and Adverse Event Report in which the FDA stated“[w]hile the FDA does not have enough data presently to conclude that Vitamin E acetate is the cause of the lung injury in these cases, the agency believes it is prudent to avoid inhaling this substance.
  • THC vaping products may contain Vitamin E acetate
  • consumers are urged to avoid buying vaping products from the street, and to refrain from using THC oil or modifying/adding any substances to products purchased in stores.”
  • the present specification thus provides an alternative to such undesirable additives.
  • the additive of the present disclosure can be a single material or a blend of different materials.
  • the rate of addition of the additive to the cannabinoid source can be adjusted according to expected storage or the vape device’s operational parameters.
  • a single additive is added to the cannabinoid source. This simplifies the manufacturing of the vape oil and may increase regulatory approval likelihood by local regulatory bodies.
  • two or more different additives to be added to the cannabis concentrate, especially when particular further advantageous properties are to be obtained.
  • a first additive having a flash point above the vaporization temperature may be used together with a second additive having a flash point below the vaporization temperature.
  • the overall proportion of cannabinoid source required to obtain a suitable flash point for the whole mixture may not be as high compared to the situation where the additive(s) has (have) a flash point below the vaporization temperature.
  • cannabinoid source may be required to have a vape oil with suitable flash point, although the person of skill may still wish to include higher proportion of cannabinoid source in other to increase potency of the vape oil, i.e., increase the concentration of cannabinoid(s) in the vape oil.
  • the vape oil containing a cannabinoid of the present disclosure includes a mixture of the cannabinoid source and the additive, where the cannabinoid source and the additive are present in respective proportions such that the vape oil has a viscosity at room temperature which is below the viscosity threshold (i.e., maximum working viscosity) of a vape device.
  • the vape device may have a viscosity threshold of £ 150 000 mPa-s, or £ 125 000 mPa-s, or £ 110 000 mPa-s, or £ 100 000 mPa-s, or £ 95 000 mPa-s.
  • the vape device may have an operational viscosity range of from 1000 to 110 000 mPa-s.
  • a vape device may have a specification relating to the ceramic core characteristics which allow use of a vape oil having low viscosity values (e.g., 1000 mPas-s), however, in some embodiments, use of such low viscosity values for a vape oil may not be desirable, in particular when leakage of vape oil may occur through the airflow system resulting in subpar user experience or, even of more concern, when leakage of vape oil may occur through lower parts of the vape cartridge exposing the vape oil to the battery compartment (e.g., ignition source).
  • the battery compartment e.g., ignition source
  • vape oil containing a cannabinoid with reasonable viscosity values, e.g., in the range of from 4000 to 100 000 mPa-s, or up to 90 000 mPa-s, or up to 80 000 mPa-s, or up to 70 000 mPa-s, or up to 60 000 mPa-s, or up to 50 000 mPa-s, and the like.
  • the cannabinoid source and the additive can be present in respective proportions such as 3 20 wt.%, or 3 30 wt.%, 3 40 wt.%, 3 50 wt.%, 3 60 wt.%, 3 70 wt.%, 3 80 wt.%, 3 90 wt.%, 3 95 wt.%, or about 98 wt.% relative to the weight of the vape oil.
  • the vape oil of the present disclosure retains sufficient free-flowing liquid properties to afford ease of use with the vape device.
  • the additive is of plant origin.
  • the additive can be, but without being limited to, one or more terpene(s) or essential oil(s).
  • the additive may include one or more of d- limonene, Orange sweet (Citrus sinensis), b-myrcene, Pine (Pinus sylvestris), Fir (Abies siberica or Abies balsamea), Juniper Berry (Juniperus communis), lemon Lime Flavor, peppermint oil, and the like.
  • Cannabis is a genus of flowering plants that includes a number of species. The number of species is currently being disputed. There are three different species that have been recognized, namely Cannabis sativa, Cannabis indica and Cannabis ruderalis. Hemp, or industrial hemp, is a strain of the Cannabis sativa plant species that is grown specifically for the industrial uses of its derived products. Hemp has lower concentrations of THC and higher concentrations of cannabidiol (CBD), which decreases or eliminates its psychoactive effects.
  • CBD cannabidiol
  • Cannabisbis plant(s) encomPa-sses wild type Cannabis and also variants thereof, including cannabis chemovars which naturally contain different amounts of the individual cannabinoids.
  • Cannabis strains have been bred to produce minimal levels of THC, the principal psychoactive constituent responsible for the high associated with it and other strains have been selectively bred to produce high levels of THC and other psychoactive cannabinoids.
  • Cannabis plants produce a unique family of terpeno-phenolic compounds called cannabinoids, which produce the“high” one experiences from consuming marijuana. There are 483 identifiable chemical constituents known to exist in the cannabis plant, and at least 85 different cannabinoids have been isolated from the plant. The two cannabinoids usually produced in greatest abundance are cannabidiol (CBD) and/or A9-tetrahydrocannabinol (THC), but only THC is psychoactive.
  • CBD cannabidiol
  • THC A9-tetrahydrocannabinol
  • Cannabis plants are categorized by their chemical phenotype or“chemotype,” based on the overall amount of THC produced, and on the ratio of THC to CBD.
  • THC/CBD ratio is genetically determined and remains fixed throughout the life of a plant.
  • Non-drug plants produce relatively low levels of THC and high levels of CBD, while drug plants produce high levels of THC and low levels of CBD.
  • a cannabinoid is generally understood to include any chemical compound that acts upon a cannabinoid receptor such as CB1 and CB2.
  • a cannabinoid may include endocannabinoids (produced naturally by humans and animals), phytocannabinoids (found in cannabis and some other plants), and synthetic cannabinoids (manufactured artificially).
  • phytocannabinoids include, but are not limited to, cannabigerolic acid (CBGA), cannabigerol (CBG), cannabigerol monomethylether (CBGM), cannabigerovarin (CBGV), cannabichromene (CBC), cannabichromevarin (CBCV), cannabidiol (CBD), cannabidiol monomethylether (CBDM), cannabidiol-C4 (CBD-C4), cannabidivarin (CBDV), cannabidiorcol (CBD-C1), delta-9-tetrahydrocannabinol (A 9 -THC), delta-9- tetrahydrocannabinolic acid A (THCA-A), delta-9-tetrahydrocannabionolic acid B (THCA-B), delta-9-tetrahydrocannabinolic acid-C4 (THCA-C4), delta-9-tetrahydrocannabino
  • the terms“cannabidiol” or“CBD” are generally understood to refer to one or more of the following compounds, and, unless a particular other stereoisomer or stereoisomers are specified, includes the compound“A 2 -cannabidiol.” These compounds are: (1) D 5 - cannabidiol (2-(6-isopropenyl-3-methyl-5-cyclohexen-l-yl)-5-pentyl-l,3-benzenediol); (2) D 4 - cannabidiol (2- (6-isopropenyl-3-methyl-4-cyclohexen-l-yl)-5-pentyl-l,3-benzenediol); (3) D 3 - cannabidiol (2-(6- isopropenyl-3-methyl-3-cyclohexen-l-yl)-5-pentyl-l,3-benzenediol); (4) D 3 ’ 7 - cannabidiol (2-(6- is
  • Examples of synthetic cannabinoids include, but are not limited to, naphthoylindoles, naphthylmethylindoles, naphthoylpyrroles, naphthylmethylindenes, phenylacetylindoles, cyclohexylphenols, tetramethylcyclopropylindoles, adamantoylindoles, indazole carboxamides, and quinolinyl esters.
  • a cannabinoid may be in an acid form or a non-acid form, the latter also being referred to as the decarboxylated form since the non-acid form can be generated by decarboxylating the acid form.
  • the cannabinoid can be in its acid or non-acid form, or be a mixture of both acid and non-acid forms.
  • Terpenes are produced by a large variety of plants. As used herein, terpenes include terpenoids.
  • Terpenes may be classified in various ways, such as by their sizes.
  • suitable terpenes may include monoterpenes, sesquiterpenes, or triterpenes. At least some terpenes are expected to interact with, and potentiate the activity of, cannabinoids.
  • Examples of terpenes known to be extractable from cannabis include aromadendrene, bergamottin, bergamotol, bisabolene, borneol, 4-3-carene, caryophyllene, cineole/eucalyptol, p- cymene, dihydroj asmone, elemene, farnesene, fenchol, geranylacetate, guaiol, humulene, isopulegol, limonene, linalool, menthone, menthol, menthofuran, myrcene, nerylacetate, neomenthylacetate, ocimene, perillylalcohol, phellandrene, pinene, pulegone, sabinene, terpinene, terpineol, 4-terpineol, terpinolene, and derivatives thereof.
  • terpenes include nerolidol, phytol, geraniol, alpha-bisabolol, thymol, genipin, astragaloside, asiaticoside, camphene, beta-amyrin, thujone, citronellol, 1,8- cineole, cycloartenol, and derivatives thereof.
  • the cannabinoid source includes a semi-synthetic cannabinoid.
  • the manufacture of cannabinoid compounds and their analogs using semi-synthetic means involves contacting an appropriate substrate with one of the cannabinoid synthase enzymes.
  • tetrahydrocannabinolic acid (THCA) or its analogs can be manufactured semi-synthetically by contacting cannabigerolic acid (CBGA) or an appropriately substituted derivative of CBGA with THC synthase to obtain the corresponding THCA or THCA analog respectively.
  • CBGA cannabigerolic acid
  • Other means for manufacturing semi-synthetically cannabinoids may involve, for example, cell culture of genetically modified cells, which have been modified so as to produce cannabinoids.
  • the cannabinoid source is obtained by an extraction process from plant materials, such as a cannabis plant (including hemp).
  • plant materials such as a cannabis plant (including hemp).
  • Extraction in natural products chemistry is a separation process comprising the separation of a substance from a matrix of natural materials and includes liquid-liquid extraction, solid phase extraction and what is commonly referred to as super-critical extraction.
  • the distribution of any given compound or composition between two phases is an equilibrium condition described by partition theory. This is based on exactly how the desired material moves from a first solution, typically water or other material capable of dissolving a desired material with a first solubility of the desired material, into second material, typically an organic or other immiscible layer having a second solubility of the desired material layer.
  • Super-critical (supercritical) extraction involves entirely different phenomenon and will be described below.
  • There exist several types of extraction including liquid-liquid extraction, solid-phase extraction, solid-phase microextraction, Soxhlet extraction, fizzy extraction and super-critical C0 2 (supercritical carbon dioxide) extraction.
  • a first option one may extract plant materials using C0 2 extraction (under sub- critical or super-critical conditions) in order to obtain the cannabinoid source.
  • the process is exempt of a winterization, evaporation or distillation step so as to retain some waxes and/or terpenes endogeneously present in the plant materials.
  • Subcritical C0 2 defines C0 2 at the state between 5-10°C (278.15-283.15K, 41-50°F) and a pressure of between 800-1500psi (54.43-102.06atm, 5.51-10.24MPa). At this temperature and pressure, C0 2 behaves as a thick fluid.
  • US 7,700,368 generally describes extraction/purification of cannabinoids or cannabinoid acids from any plant material known to contain such cannabinoids or cannabinoid acids, such as wild type Cannabis sativa and also variants thereof, including cannabis chemovars (varieties characterised by virtue of chemical composition) which naturally contain different amounts of the individual cannabinoids, also Cannabis sativa subspecies indica including the variants var. indica and var. kafiristanica, Cannabis indica and also plants which are the result of genetic crosses, self-crosses or hybrids thereof.
  • cannabinoids or cannabinoid acids such as wild type Cannabis sativa and also variants thereof, including cannabis chemovars (varieties characterised by virtue of chemical composition) which naturally contain different amounts of the individual cannabinoids, also Cannabis sativa subspecies indica including the variants var. indica and var. kafiristanica, Cannabis indica and also plants which are the result of genetic
  • US 2004/0049059 generally describes a method for producing an extract from cannabis plant matter, containing tetrahydrocannabinol, cannabidiol and optionally the carboxylic acids thereof, from industrial hemp and from drug-producing hemp.
  • a second option one may extract plant materials using polar solvent extraction (e.g., ethanol, butane, etc.).
  • polar solvent extraction e.g., ethanol, butane, etc.
  • this process is also exempt of a winterization, evaporation or distillation step so as to retain some waxes and/or terpenes endogeneously present in the plant materials, which can operate as the herein described solubilizing aiding agent.
  • the cannabinoid source will still include some waxes and/or terpenes which are endogenously present in the hemp or cannabis plant material.
  • the presence of these waxes and/ or terpenes can have the benefit of being able to operate as a solubilizing aiding agent.
  • the presence of such compounds in the resulting cannabinoid source may render the cannabinoid source too viscous for use in a vape device and also may impart a dark color to the vape oil, which makes the cannabinoid source less visually attractive for direct use in a vape device that typically have clear liquid reservoir for holding the vape oil.
  • the cannabinoid source can be diluted in an additive / carrier oil (e.g., at least one thereof) which is less opaque and less viscous than the cannabinoid source.
  • the cannabinoid source when the cannabinoid source is obtained by extraction from cannabis plant materials (including hemp) through an extraction process exempt of a winterization step, the cannabinoid source is, thus, exempt of a winterization solvent, e.g., ethanol.
  • a winterization solvent e.g., ethanol
  • An objective manner to assess whether the cannabinoid source is prepared from a process exempt of such winterization step is to measure the amount of winterization solvent (e.g., ethanol) present in the cannabinoid source prior to mixing with the additive / carrier oil.
  • the herein described cannabinoid source is, thus, free from winterization solvent.
  • Another practical way of assessing whether the cannabinoid source is prepared from a process exempt of such winterization step is to determine whether the cannabinoid source still includes endogenous plant waxes and/or terpenes which are typically removed through the winterization step.
  • a winterization step such as a winterization step, evaporation step and/or a distillation step.
  • US 2016/0346339 which is incorporated by reference in its entirety, describes a process for extracting cannabinoids from hemp or cannabis plant material using solvent extraction followed by filtration, and evaporation of the solvent in a distiller to obtain a distillate. Implementing these processes is said to result in a cannabinoid having a chromatographic purity of greater than 99%.
  • the endogenous waxes and/or terpenes are removed by the purification step(s) and one obtains a cannabinoid source which can be substantially one or more pure cannabinoid(s).
  • a cannabinoid source can be in crystal form or in semi-solid form (highly viscous composition) such that it is not suitable for direct use in the vape device.
  • In order to make the cannabinoid source suitable for use in the vape device requires dilution in an additive / carrier oil which is less viscous.
  • One or more of the above discussed options may include a decarboxylation step performed prior to or after the extraction step.
  • This decarboxylation step is optional in that at least some portion of the cannabinoid present in the vape oil may be decarboxylated during use in the vape device due to the high vaporization heat applied to the vape oil in the device.
  • Viscosity values for cannabinoid sources extracted from cannabis or hemp plant materials have been reported in the art, for example: W02017180660 describes CBD 80%, 60°C: 1240mPa-s, CBD 80%, 70°C: 670mPa-s, THC 80%, 60°C: 5830mPa-s, THC 80%, 70°C: 2200mPa-s; Rheosense (Rheometer manufacturers) have an application note on analyzing cannabinoid oils where they have measured viscosities at 25°C between 10 000 to 80 000 mPa-s using an unspecified shear rate between 60-200Hz; Monica Vialpando, Ph.D.— Pharmaceutical Development, Vialpando LLCy made a presentation entitled Pharmaceutical Formulation Technologies Applicable to Cannabis Product Development at the Emerald Conference 2018 (available on line), where the viscosity of THC was reported at 25°C to be 100 000 mPa-s.
  • the cannabinoid source includes one or more cannabinoid(s).
  • the cannabinoid source may include a mixture of tetrahydrocannabinol (THC) and cannabidiol (CBD).
  • THC tetrahydrocannabinol
  • CBD cannabidiol
  • the w/w ratio of THC to CBD in the vape oil may be about 1:1000, about 1:900, about 1:800, about 1:700, about 1:600, about 1:500, about 1:400, about 1:300, about 1:250, about 1:200, about 1:150, about 1:100, about 1:90, about 1:80, about 1:70, about 1:60, about 1:50, about 1:45, about 1:40, about 1:35, about 1:30, about 1:29, about 1:28, about 1:27, about 1:26, about 1:25, about 1:24, about 1:23, about 1:22, about 1:21, about 1:20, about 1:19, about 1:18, about 1:17, about 1:16, about 1:15, about 1:14, about 1:13, about 1:12, about 1:11, about 1:10, about 1
  • the vape oil of the present disclosure includes a high concentration of a cannabinoid.
  • the vape oil can include, but without being limited to, at least 300 mg/ml, or at least 350 mg/ ml, or at least 400 mg/ ml, or at least 450 mg/ ml, or at least 500 mg/ ml, or at least 550 mg/ ml, or at least 600 mg/ ml, or at least 650 mg/ ml, or more of the cannabinoid.
  • the vape oil may include more than one cannabinoid.
  • the vape oil may include relatively high concentrations of all such cannabinoids or, alternatively, of only one.
  • the vape oil may include a high concentration (3 300 mg/ml) of one cannabinoid and a low concentration (£ 30 mg/ ml) of another cannabinoid, or alternatively, the vape oil may include a high concentration (3 300 mg/ml) of all cannabinoids contained therein.
  • the vape oil includes tetrahydrocannabinol (THC).
  • the vape oil includes cannabidiol (CBD).
  • the vape oil includes more than one cannabinoid, e.g., THC and
  • the vape oil includes delta-8 THC and delta 9-THC. 7. Vape device
  • vape oil of the present disclosure can be used in any suitable cartridge component of a vape device.
  • Fig. 1 is a plan view of a non-limiting example of a cartridge 100 component of an electronic vape device.
  • the cartridge 100 includes a vapor outlet 50 at one end thereof, which includes a tip 40 and sidewalls 20 and 25, which could be sides or parts of the same cylindrical sidewall in some embodiments.
  • the cartridge 100 further includes a liquid reservoir 60 for containing the vape oil which includes the cannabinoid.
  • the vapor outlet 50 in addition to sealing an end of an interior space of the liquid reservoir 60, also provides a mouth-piece portion through which a user can draw vapor from the electronic vape device.
  • the mouthpiece could be tapered, as shown, or otherwise shaped for a user’s comfort.
  • the present disclosure is not limited to any particular shape of the vapor outlet 50.
  • the vapor outlet 50 could be made from one or more materials including metal, ceramic, wood, or a combination thereof. However, other materials could also or instead be used.
  • the liquid reservoir 60 holds the vape oil prior to vaporization.
  • the liquid reservoir 60 includes outer walls 10 and 15, which could be a single wall such as a cylindrical sidewall.
  • the outer walls 10 and 15 of the liquid reservoir 60 could be made from one or more transparent or translucent materials, such as medical grade glass, in order to enable a user to visibly determine the quantity of vape oil in the chamber.
  • the liquid reservoir 60 engages the vapor outlet 50, and could be coupled to the vapor outlet 50, via an engagement or connection at 116.
  • a gasket or other sealing member could be provided between the liquid reservoir 60 and the vapor outlet 50 to seal the vape oil in the liquid reservoir 60.
  • liquid reservoir are “non-recloseable” (or sealable) and cannot be opened after initial filling
  • others are recloseable chambers in which the engagement at 116, between the vapor outlet 50 and the liquid reservoir 60, is releasable.
  • the vapor outlet 50 could be a cover that releasably engages the liquid reservoir 60 and seals a vape oil in the liquid reservoir 60, thereby preventing the vape oil from leaking out of the liquid reservoir 60.
  • a releasable engagement could include, for example, a threaded engagement or other type of connection, or an abutment between the liquid reservoir 60 and the vapor outlet 50, without necessarily an actual connection between the chamber and the vapor outlet.
  • Such a releasable engagement permits the vapor outlet 50 to be disengaged or removed from the liquid reservoir 60 so that the chamber can be cleaned, emptied, and/ or filled with a vape oil, for example.
  • the vapor outlet 50 could then re-engage with the liquid reservoir 60 to seal the vape oil inside the chamber.
  • Fig. 1 also illustrates a stem 110 inside the liquid reservoir 60.
  • the stem 110 is a hollow tube or air channel through which vapor can be drawn into and through vapor outlet 50.
  • the stem 110 may also be referred to as a central column, a central post, a chimney, a hose or a pipe. Materials such as stainless steel, other metal alloys, plastics and ceramics could be used for stems such as the stem 110.
  • the stem 110 couples the vapor outlet 50 via an engagement or connection (not shown).
  • the stem 110 may include at its base one or more intake holes (not shown) having a suitable opening size, such as for example 1.2 or 1.6 mm.
  • screwing the vapor outlet 50 onto the stem 110 could also engage the vapor outlet 50 with the liquid reservoir 60, or similarly screwing the vapor outlet 50 onto the liquid reservoir 60 could also engage the vapor outlet 50 with the stem 110.
  • Fig. 2 shows a battery compartment 200 that includes supplies power to the cartridge 100.
  • the battery compartment 200 engages, and could also be coupled to the cartridge 100 via a female engagement 130 defined within a receiving body 120, which receives a male thread 30 present at an end of the cartridge 100.
  • the engagement 130 and thread 30 is a releasable engagement.
  • this could be a fixed connection.
  • the thread 30 may take the form of a 510 thread, which typically may include a connector having a length of 5 mm and having 10 threads.
  • the batery compartment 200 generally includes circuitry to supply power to the cartridge 100.
  • the batery compartment 200 could include electrical contacts that connect to corresponding electrical contacts with the battery.
  • the batery compartment 200 could further include electrical contacts that connect to corresponding electrical contacts in the cartridge 100.
  • the battery compartment 200 could reduce, regulate or otherwise control the power/voltage /current output from the batery.
  • this functionality could also or instead be provided by the battery itself.
  • the battery compartment 200 could be made from one or more materials including metals, plastics, elastomers and ceramics, for example, to carry or otherwise support other base components such as contacts and/or circuitry. However, other materials could also or instead be used.
  • the battery compartment 200 includes sidewalls 140 and 141, a bottom 142 and a button 144.
  • the sidewalls 140 and 141 could be a single wall such as a cylindrical sidewall.
  • the battery compartment 200 could include single-use batteries or rechargeable batteries such as lithium-ion batteries.
  • the battery compartment 200 powers the vape device and allows powered components of the vape device, including at least the cartridge 100, to operate.
  • Other powered components could include, for example, one or more light-emiting diodes (LEDs), speakers or other indicators of device power status (on / off), device usage status (on when a user is drawing vapor), etc.
  • speakers and/ or other audible indicators could produce long, short or intermittent“beep” sounds as a form of indicator of different conditions.
  • the vapor outlet 50, the liquid reservoir 60, the stem 110, and the battery compartment 200 are cylindrical in shape or otherwise shaped in a way such that sidewalls that are separately labeled in Fig. 1 and/or Fig. 2 could be formed by a single sidewall.
  • the sidewalls 140 and 141 represent sides of the same sidewall. Similar comments apply to outer walls 10 and 15, and sidewalls 20 and 25, and other walls that are shown in the drawings and/or described herein.
  • vapor outlets, liquid reservoirs, stems, cartridges, battery compartments that are not cylindrical in shape are also contemplated.
  • these components could be rectangular, triangular, or otherwise shaped.
  • the example cartridge 100 and the example battery compartment 200 are solely for the purpose of illustration.
  • the vape device could be a multi-chamber device vape device or a pen-and-pod device as commercialized by PAX (e.g., the PAX EraTM).
  • Fig. 3 is an isometric view of another example vape device 300.
  • Reference number 301 in Fig. 3 generally designates a vape device tank, with a ceramic core 302 coupled to a chamber 303 that stores a vape oil.
  • the vape device tank 301 is powered by a power source (e.g., a battery) inside a compartment 305 that physically and electrically connects to the vape device tank.
  • the vape device 300 has a control system (not shown) for controlling the supply of power from the power source to the vape device tank 301.
  • the vape oil from the chamber 303 flows or seeps into the ceramic core 302, which heats the vape oil using a heating element (not shown) enough to atomize or vaporize the vape oil, thereby producing vapor.
  • the vapor can be drawn out of the ceramic core 302 through a stem 304 and out of the vape device 300 through a mouthpiece 306.
  • the structure and operation of the vape device 300 are consistent with those of the example vape device in Figs. 1 and 2, and is presented as a further example to illustrate another shape and form factor of a vape device. Embodiments of the present disclosure may be implemented in conjunction with these and/ or other types of vape devices.
  • Fig. 4 is an isometric view of an example vape device tank 400 including a ceramic core 402.
  • the vape device tank 400 is shown with a section removed so that internals of the vape device tank can be seen.
  • the vape device tank 400 and the ceramic core 402 are cylindrical in shape.
  • the vape device tank 400 can be implemented in a vape device, a non-limiting example of which are shown in Fig 3. It is to be understood that the vape device tank 400 is a very specific example and is provided for illustrative purposes only.
  • the vape device tank 400 has a chamber 407 for storing the vape oil including the cannabinoid.
  • the chamber 407 is cylindrical in shape and at least partially surrounds the ceramic core 402, and is in fluid communication with the ceramic core via an inlet 401.
  • the ceramic core 402 receives the vape oil from the chamber 407 through the inlet 401.
  • there is no such inlet 401 or chamber 407 and the vape oil is supplied to the ceramic core 402 by other means such as manual application by a user, for example.
  • the ceramic core 402 has a heating element 404 at least partially embedded therein.
  • the heating element 404 heats the ceramic core and produces a vapor from the vape oil. More generally, a heating element could be coupled to a ceramic core in other ways, such as being coupled to a surface of the ceramic core.
  • a physical characteristic of the ceramic core 402, such as density or porosity, enables the vape oil to flow through the ceramic core, particularly when the vape oil has been heated by the heating element 404 to reduce its viscosity.
  • Ceramics include a combination of ingredients, for example water, resin and other binders. Many ceramics also include a combination of oxides and/or nitrides such as those formed by compounds of aluminum, lead, silicon, boron, magnesium, and titanium for example. Some notable examples include aluminium oxide, silicon nitride, beryllium oxide, and aluminum nitride. In some applications, these compounds may be combined with oxides of nickel manganese, cobalt, and/or iron. Silica may also be used in microporous ceramics. In some embodiments, a ceramic core may be made from 99A1 2 0 3 , 97A1 2 0 3 , sapphire and/ or Zr0 2 . The ceramic core 402, as well as the other ceramic cores disclosed herein, could be formed of different combinations of ingredients to achieve different physical characteristics such as porosity or density, for example, to obtain a plurality of nanoscale holes.
  • the vape device tank 400 has an element or component to feed the vape oil to the ceramic core 402.
  • An example of such an element or component is a wick as shown at 403, disposed between the ceramic core 402 and the chamber 407.
  • the wick 403 is made from cotton or any other suitable material that has a lower porosity than the ceramic core 402.
  • the porosity of the wick 403 is high enough so that the vape oil can easily flow through and make contact with the ceramic core 402 even without any heating from the heating element 404 embedded in the ceramic core.
  • the wick 403 may help provide more even contact between the vape oil and the ceramic core 402.
  • a vape device tank has no such wick 403.
  • the heating element 404 is a coil heater with a number of coil turns or loops embedded in the ceramic core 402. Three of these coil turns or loops are identified by an oval in the illustrated example, but more coil turns or loops are visible in Fig. 4. The number of coil turns or loops is implementation specific. Other examples of heaters or heating elements are also provided herein.
  • the coil heater 404 is embedded into the ceramic core 402 during manufacture of the ceramic core in some embodiments.
  • the ceramic core 402 has a heat capacity, and thus embedding the coil turns or loops in the ceramic core can help to avoid a faulty situation in which the coil turns or loops directly contact the vape oil and become too hot, burning rather than vaporizing the vape oil or at least certain components of the vape oil.
  • a channel 405 is in fluid communication with the ceramic core 402 to receive vapor from the ceramic core.
  • the ceramic core 402 at least partially surrounds the channel 405.
  • the heating element 404 is positioned closer to an inside or interior portion of the ceramic core 402 and closer to the channel 405 as shown, such that the vape oil may reach progressively higher temperatures as it flows through the ceramic core towards the channel 405.
  • the vape oil flowing through the ceramic core 402 is sufficiently heated, it is atomized or vaporized to produce a vapor, which can be drawn out through the channel 405.
  • the heating element 404 is positioned in a middle portion of the ceramic core 402.
  • the heating element 404 is positioned outside of the ceramic core 402 and around or in the channel 405.
  • the temperature at which the vape oil is vaporized to produce the vapor may depend on any one or more of a number of factors such as the vape oil being used, the cannabinoid to be vaporized, thermal conductivity of the ceramic core 402, and/or thermal conductivity of the vape oil itself.
  • the temperature at which the vape oil is vaporized may be around 300°F or higher. In a specific example, the temperature of the vape oil should not exceed 600°F or else it may burn.
  • the heating element 404 heats up the ceramic core 402 and generates vapor by vaporizing the vape oil flowing through the ceramic core.
  • the vapor can be drawn out through the channel 405, and an air inlet 406 is disposed beneath the ceramic core 402 to facilitate airflow for the channel 405.
  • the heating element 404 is powered by a power source (not shown) and controlled by a control system (not shown).
  • the power source and the control system are disposed in a compartment that physically and electrically connects to the vape device tank 400. Such connections include electrical connections (not shown) between the heating element 404 and the power source and/or the control system.
  • a practical implementation of a method 500 of manufacturing a vape device for vaping a cannabinoid such as a vape oil cartridge or vape pen in accordance with an embodiment of the present disclosure.
  • step 510 one is provided with the vape device, where the vape device is characterized with operating parameters for vaping a vape oil, for example, a vape oil containing a cannabinoid.
  • operating parameters may include, for example, ceramic core porosity and mass transfer characteristics, heating element resistance, working range of vape oil viscosity, volume for liquid reservoir, and the like.
  • one is not provided with the actual physical vape device, but rather, one can be provided with only one or more relevant operating parameters of the vape device, for example.
  • one is not provided with the actual physical vape device or with the operating parameters of the vape device, but rather, one determines the one or more relevant operating parameters of the vape device based on information stored in an electronic database, information provided by the vape device manufacturer, and the like.
  • Step 550 one formulates the vape oil containing the cannabinoid at least based on one or more relevant operating parameters of the vape device obtained and/or determined in step 510.
  • Step 550 may include, for example, selecting a cannabinoid source including a cannabinoid, the cannabinoid having a vaporization temperature, the cannabinoid source having a viscosity at room temperature which is above the viscosity at room temperature suitable for use in the vape device and having a flash point above the vaporization temperature.
  • Step 550 may further include selecting an additive having a viscosity below the vape oil viscosity and having a flash point below the vaporization temperature, the additive operating to lower the viscosity of the cannabinoid source and operating to lower a flash point of a mixture of the cannabinoid source and the additive.
  • Step 550 may further include mixing the cannabinoid source and the additive in proportions such that the additive is in a concentration that (i) will reduce the viscosity of the cannabinoid source sufficiently low for the mixture to be suitable for use in the vape device and (ii) while avoiding reducing the flash point of the mixture below the vaporization temperature.
  • step 590 one fills a reservoir of the vape device with the vape oil obtained in step 550, for example using a pipette.
  • step of filling the reservoir may be performed by the same person formulating the vape oil or may be performed by another individual, for example.
  • Fig. 6 illustrates a process 600 which implements the latter case.
  • the process 600 also includes step 550 of formulating the vape oil containing the cannabinoid at least based on one or more relevant operating parameters of the vape device obtained and/or determined as previously discussed.
  • the vape oil is then packaged and released for transportation to another location (e.g., at a 3 rd party). At this other location, the vape oil is filled into the reservoir of the vape device in a step 650.
  • Fig. 7 illustrates a process 700 whereby at step 555 one selects a cannabinoid source containing a cannabinoid.
  • This selection can be based on at least one of a customer request, a desired cannabinoid profile (e.g., a given ratio of THC to CBD), a desired user experience (e.g., high potency THC vs low potency THC), and the like.
  • the cannabinoid source has a viscosity at room temperature which is above the viscosity at room temperature suitable for use in the vape device and the cannabinoid has a vaporization temperature.
  • one selects an additive having a flash point below the vaporization temperature, the additive operating to lower the viscosity of the cannabinoid source and operating to lower a flash point of a mixture of the cannabinoid source and the additive.
  • one mixes the cannabinoid source and the additive in predetermined proportions so as to obtain a vape oil having a viscosity suitable for use in the vape device and a flash point above the vaporization temperature.
  • the amount of additive required to obtain a suitable flash point and viscosity for the mixture can be determined / selected based on an actual calculation of the suitable additive concentration. In other embodiments, the amount of additive required to obtain a suitable flash point and viscosity for the mixture can be determined / selected based on measurements of the viscosity using a rheometer and/or of the flash point using a suitable ASTM test.
  • the amount of additive required to obtain a suitable flash point and viscosity for the mixture can be determined / selected based on previously calculated and/or measured viscosity and flash point values, e.g., looking up in an internal standard operating procedure (SOP) or in an internal database for a recipe that provides the proportions for a given formulation.
  • SOP standard operating procedure
  • other examples of implementation will become apparent to the person of skill and for conciseness sake will not be further described here.
  • the expression“viscosity threshold” in reference to the operating parameter for a vape device means the highest viscosity value at room temperature for a vape oil which remains suitable for use in the vape device and allow proper use of that vape device, e.g., for properly feeding the vape oil through the ceramic core of the vape device in order to vaporize the cannabinoid contained in the vape oil while minimizing clogging of internal components of the cartridge, for assisting with the performance of the vape device such as by preventing or minimizing leakage of the vape oil from the vape device when not in use, and optimizing the performance of the vape device and its delivery of the cannabinoid, and the like.
  • the expression“cannabis oil” refers to an oil that contains a cannabinoid and that is in liquid form at a temperature of 22 ⁇ 2°C.
  • MCT medium chain triglycerides
  • Rich food sources for commercial extraction of MCT include palm kernel oil and coconut oil.
  • VG vegetable glycerin
  • PEG polyethylene glycol
  • PEO polyethylene oxide
  • POE polyoxyethylene
  • propane-1, 2-diol propane-1, 2-diol and refers to a synthetic organic compound with the chemical formula C 3 H 8 0 2 .
  • the term“of plant origin” is used interchangeably with “plant-based” or with “plant-derived” and refers to a compound that is extracted or prepared from plant raw material. In one embodiment, this compound can be synthetic.
  • essential oil does not mean indispensable as with the terms essential amino acid or essential fatty acid which are so called since they are nutritionally required by a given living organism, rather, the essential oil is “essential” in the sense that it contains the“essence of’ or“at least a portion of the essence of’ the plant’s fragrance - the characteristic fragrance of the plant from which it is derived.
  • Essential oils are generally extracted by distillation, often by using steam. Other processes include expression, solvent extraction, sfumatura, absolute oil extraction, resin tapping, wax embedding, and cold pressing. As such, in the present disclosure, essential oils are a concentrated hydrophobic liquid containing volatile aroma compounds from plants.
  • flash point refers to the lowest temperature at which vapors of a material will ignite, when given an ignition source.
  • Methods for determining the flash point of a liquid are specified in many standards. For example, testing by the Pensky-Martens closed cup method is detailed in ASTM D93, IP34, ISO 2719, DIN 51758, JIS K2265 and AFNOR M07-019. Determination of flash point by the Small Scale closed cup method is detailed in ASTM D3828 and D3278, EN ISO 3679 and 3680, and IP 523 and 524.
  • vaporization temperature in reference to a cannabinoid means the temperature required to vaporize the cannabinoid, e.g., the temperature at which the cannabinoid in the vape oil exposed to said temperature is converted into a vapor.
  • vape cartridges or vape pens were used in order to test vape oils prepared in the present application.
  • an A3-C full ceramic vape cartridge (Transpring Technology, USA) can be used, having a full ceramic heating core, a 0.5 ml liquid reservoir, a resistance of 1.4/1.6W, and 1.2 mm/1.6 mm oil intake hole size.
  • the liquid reservoir is made of medical grade glass and the rest of the cartridge is made of chrome -plated brass.
  • the cartridge includes a 510 thread for coupling with the battery compartment.
  • a Jupiter Tiquid 6 cartridge (Jupiter Research, Arizona, USA) can be used, having a CCETT Technology designed for high viscosity oils, porcelain ceramic mouthpiece, a 0.5 ml liquid reservoir, 2.0 mm oil intake hole size, nichrome heating element and a ceramic core.
  • the cartridge includes a 510 connection— M7 threaded connection for coupling with the battery compartment.
  • a number of battery packs can be used with vape cartridges.
  • an T0-A vape battery compartment (Transpring Technology) can be used 1.
  • the T0-A vape battery has a capacity of 320 mAh, an output voltage of 2.6-4.0V with 3 adjustable voltages (green 2.6V, blue 3.3V, red 4.0V), a preheating output of 1.8V, a preheating time of 15 seconds, and 2 optional vaping ways: vape directly / vape with button-pressing.
  • an T6 vape power supply (Jupiter Research) can be used.
  • the T6 vape power supply has a capacity of 340 mAh, a resistance of 0.9— 3.0 W, and an activation time of 0- 10 seconds.
  • an additive having a proper flash point i.e., at least 200 °F (at least 93.3 °C). This is because a number of cannabinoids require temperatures of at least 200 °F in order to vaporize (e.g., CBD is within the range of 320-356 °F, THC is about 315 °F, CBN is about 365 °F such that having a cannabis vape oil containing an additive with a flash point below 200 °F in proportions sufficient to reduce the flash point of the mixture to values below 200 °F would likely represent a fire / explosion hazard when heated in the vaping device.
  • CBD is within the range of 320-356 °F
  • THC is about 315 °F
  • CBN is about 365 °F
  • the inventors first set out to identify the flash point of a number of candidate additives.
  • the following table 1A sets out the flash point of these candidate additives as reported in the literature:
  • the additives assessed are petroleum-based propylene glycol (PG) and polyethylene glycol 400 (PEG 400), and natural agents vegetable glycerin (V G) and medium chain triglycerides (MCT). Troutt and DiDonato Altern Complement Med. 2017 Nov;23(ll):879-884) report that heating these oils at temperatures appropriate for cannabis oil vaporization (e.g., at 230 °C) resulted in formation of vapor containing harmful carbonyls, such as acetaldehyde, acrolein, and formaldehyde.
  • PG propylene glycol
  • PEG 400 polyethylene glycol 400
  • V G vegetable glycerin
  • MCT medium chain triglycerides
  • each thinning agent was vaporized in 3 blocks of 25‘puffs’, for a total of 75 puffs per agent. Puffs were vaporized every 30 seconds, each for a duration of 4 seconds and a volume of 55 mL. The vapor was then analyzed using high-performance liquid chromatography (HPLC) to individually measure amounts of acetaldehyde, acrolein, and formaldehyde.
  • HPLC high-performance liquid chromatography
  • the inventors have concluded that the PG, PEG and VG typically used in nicotine-based vaping devices are not without health risk when used in a vape oil. Therefore, the vape oil of the present disclosure is preferably devoid of any of PG, PEG and VG.
  • the cannabinoid source even though an additive mixed with the cannabinoid source has a flash point below the desired vaporization temperature, the cannabinoid source, nevertheless, owing to its relatively high flash point operates to increase the flashpoint of the mixture such that it is above the desired vaporization temperature. Accordingly, it is therefore possible to provide a vape oil for vaping that is safe, in terms of reducing the likelihood of explosion in the vape device that would otherwise result while being compatible with the operating parameters of the vape device, e.g., that has a viscosity which is in the proper range for use in a given vape device (below the threshold viscosity).
  • vape oil formulations prepared by mixing a cannabinoid source obtained from a C0 2 extraction process and contained 2.14% THC and 84.6 % CBD, which was not been winterized / distilled and diluted with 50 ml peppermint oil at room temperature without heating.
  • the first calculation took into effect the contribution of CBD to peppermint oil, with the following equation: l/(wt.% CBD x CBD average flash point) + (wt.% peppermint oil x peppermint oil average flash point).
  • the first calculation gave a first calculated flash point of 93.69 °C— higher than the flash point of peppermint oil on its own.
  • the inventors made a second calculation using a similar formula by adding the contribution of THC, which resulted in a second calculated flash point of 98.48 °C.
  • the inventors then made a third calculation by taking into account the remaining cannabinoids and wax content present in the cannabinoid source (as determined from a certificate of analysis which determined the fatty acid content of the cannabinoid source using Gas Chromatography with Flame Ionization Detector [GC-FID] ) in terms of their effect on the flash point; the inventors calculated that the contribution of the remaining cannabinoids was a factor of 1.68, which resulted in a third calculated flash point of 157.39 °C (314.6 °F).
  • GC-FID Gas Chromatography with Flame Ionization Detector
  • the inventors sought to test the amount of cannabinoid which could be solubilized in a carrier oil with a cannabinoid source in presence of a solubilizing aiding agent.
  • the solubilizing aiding agent is an endogenous component present in the cannabis plant material, e.g., plant waxes and/or terpenes.
  • the cannabinoid source was obtained from a C0 2 extraction process and contained 2.14% THC and 84.6 % CBD, which was not been winterized / distilled and diluted with 50 ml peppermint oil at room temperature without heating.
  • vape oil having up to 2880 mg/ ml CBD could be obtained, which still flows at room temperature and can still be pipetted in a pipette, i.e., meeting the desired characteristic that the mixture remains liquid at room temperature.
  • the inventors repeated the experiment with a cannabinoid source containing THC and a cannabinoid source containing CBD and obtained a first vape oil comprising 30 mg/ml of THC and 666 mg/ ml CBD and a second vape oil comprising 20 mg/ ml of THC and 466 mg/ ml CBD, where the first and second vape oils each still have a suitable viscosity for use in the vape cartridge.
  • Example 6 was repeated with the same cannabinoid source diluted with 100 ml peppermint oil at room temperature without heating.
  • the steady-state viscosity values at various temperatures of different cannabinoid sources was measured using an MCR 92 from Anton Paar, with a 25 mm Cone- Plate measuring geometry operated in rotational mode at 25°C and a constant shear rate of 10 Hz (15 points across 45 seconds).
  • the additives in blend #1 are present in a relative ratio of about 2:1:1, i.e., humulene (oc- Caryophyllene) : beta pinene : natural myrcene.
  • additives in blend #2 are present in a relative ratio of about 1:1.
  • the additives in blend #3 are present in a relative ratio of about 2:1, i.e., humulene (oc- Caryophyllene) : D-limonene.
  • the additives in blend #4 are present in a relative ratio of about 2:1:1, i.e., humulene (oc- Caryophyllene) : delta 3 carene : caryophyllene acetate.
  • the additives in blend #5 are present in a relative ratio of about 2:1:1, i.e., caryophyllene acetate : humulene (oc-Caryophyllene) : natural myrcene.
  • additives in blend #6 are present in a relative ratio of about 1.5:1, i.e., D-limonene : humulene (oc-Caryophyllene).
  • the additives in blend #7 are present in a relative ratio of about 1:1.
  • the additives in blend #8 are present in a relative ratio of about 1:1:1.
  • the additives in blend #8 are present in a relative ratio of about 1.5:1, i.e., caryophyllene acetate : orange terpenes.
  • the additives in blend #9 are present in a relative ratio of about 7:1, i.e., orange terpenes : maltol isobutyrate.
  • the cannabinoid source was obtained from a C0 2 extraction process with an additional distillation step.
  • the inventors mixed a number of terpenes with a cannabinoid source in various proportions to test for the modulating effect of terpenes on the viscosity of cannabinoid distillate.
  • the cannabinoid source was THC obtained from a C0 2 extraction process with an additional distillation step.
  • cannabinoid source having certain levels of CBD and/or THC
  • cannabinoid source having different levels of these cannabinoids, or having different cannabinoids other than THC and/ or CBD.
  • the terms“around”,“about” or“approximately” shall generally mean within the error margin generally accepted in the art. Hence, numerical quantities given herein generally include such error margin such that the terms “around”,“about” or “approximately” can be inferred if not expressly stated.

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Abstract

La présente invention concerne un procédé de fabrication à l'échelle industrielle pour la fabrication d'huile de vapotage comprenant un cannabinoïde, l'huile de vapotage ayant une viscosité à température ambiante appropriée pour être utilisée dans un dispositif de vapotage avec la dilution d'une source de cannabinoïde avec un additif pour obtenir une telle viscosité tout en évitant de réduire le point d'éclair du mélange au-dessous de la température de vaporisation du cannabinoïde.
PCT/CA2019/051618 2018-11-13 2019-11-13 Procédé de fabrication d'huile de vapotage comprenant un cannabinoïde destiné à être utilisé dans un dispositif de vapotage WO2020097726A1 (fr)

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EP19884098.5A EP3880184A4 (fr) 2018-11-13 2019-11-13 Procédé de fabrication d'huile de vapotage comprenant un cannabinoïde destiné à être utilisé dans un dispositif de vapotage
CA3119204A CA3119204A1 (fr) 2018-11-13 2019-11-13 Procede de fabrication d'huile de vapotage comprenant un cannabinoide destine a etre utilise dans un dispositif de vapotage
US16/898,129 US20200297025A1 (en) 2018-11-13 2020-06-10 Method of manufacturing vape oil including a cannabinoid for use in a vape device

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CA3024052 2018-11-13
CA3024052A CA3024052A1 (fr) 2018-11-13 2018-11-13 Huile de cannabis pour vapotage et methode d`utilisation et de fabrication
CA3024431A CA3024431C (fr) 2018-11-15 2018-11-15 Huile de cannabis pour vapotage, methode d'utilisation et de fabrication associee
CA3024431 2018-11-15
CA3024645 2018-11-19
CA3024645A CA3024645A1 (fr) 2018-11-19 2018-11-19 Huile de cannabis a haute teneur en cannabinoide destinee au vapotage, methode d'utilisation et de fabrication associee

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220378104A1 (en) * 2021-05-28 2022-12-01 Shenzhen Eigate Technology Co., Ltd. Atomizer and electronic cigarette comrpising the same
WO2023002191A1 (fr) * 2021-07-22 2023-01-26 Nicoventures Trading Limited Système de distribution comprenant un dispositif de génération d'aérosol et un matériau aérosolisable

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220211660A1 (en) * 2020-10-24 2022-07-07 Mason Cave High viscosity thc product and method of manufacture thereof
CA3217137A1 (fr) * 2021-04-29 2022-11-03 Christopher Adair Formulations dans lesquelles le cannabidiol est le constituant dominant, leurs procedes de fabrication et leurs utilisations

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2974292A1 (fr) * 2015-01-31 2016-08-04 Constance Therapeutics, Inc. Procedes de preparation d'extraits d'huile de cannabis et compositions
US20160309774A1 (en) * 2015-04-27 2016-10-27 Michael D. Wand Terpene carrier
CA3006182A1 (fr) * 2015-11-24 2017-06-01 Constance Therapeutics, Inc. Compositions d'huile de cannabis et leurs procedes de preparation
US9744200B1 (en) * 2017-01-19 2017-08-29 Oak and Crane, LLC System for producing a terpene-enhanced cannabinoid concentrate

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10639439B2 (en) * 2013-01-30 2020-05-05 Midwest Pharmaceuticals, Llc Smokeless THC and administration method thereof
US20160136213A1 (en) * 2014-11-14 2016-05-19 Charles William Paul Process to suspend cannabis oil in glycerin
US20170119040A1 (en) * 2015-10-30 2017-05-04 Lunatech, Llc Water-based vaporizable liquids, methods and systems for vaporizing same
DK3558278T3 (da) * 2016-12-22 2021-08-09 Nordiccan As Flydende cannabinoidsammensætning
WO2018152637A1 (fr) * 2017-02-22 2018-08-30 Gene Bernaudo Systèmes de composition d'agent de mélange de cigarettes électroniques
EP3600284A4 (fr) * 2017-03-20 2020-12-09 Kanabo Research Ltd. Compositions vaporisables comprenant du cannabinol
US20180221333A1 (en) * 2017-03-22 2018-08-09 Rise Research Inc Optimized cannabis-based aphrodisiac and mood enhancer
US10034907B1 (en) * 2017-04-07 2018-07-31 Gerald Echavarry Flavored and edible cannabinoid composition and method of manufacturing

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2974292A1 (fr) * 2015-01-31 2016-08-04 Constance Therapeutics, Inc. Procedes de preparation d'extraits d'huile de cannabis et compositions
US20160309774A1 (en) * 2015-04-27 2016-10-27 Michael D. Wand Terpene carrier
CA3006182A1 (fr) * 2015-11-24 2017-06-01 Constance Therapeutics, Inc. Compositions d'huile de cannabis et leurs procedes de preparation
US9744200B1 (en) * 2017-01-19 2017-08-29 Oak and Crane, LLC System for producing a terpene-enhanced cannabinoid concentrate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HRISTOVA ET AL.: "CALCULATION OF FLASH POINTS AND FLAMMABILITY LIMITS OF SUBSTANCES AND MIXTURES", JOURNAL OF THE UNIVERSITY OF CHEMICAL TECHNOLOGY AND METALLURGY, vol. 41, no. 3, 2006, pages 291 - 296, XP055708524 *
See also references of EP3880184A4 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220378104A1 (en) * 2021-05-28 2022-12-01 Shenzhen Eigate Technology Co., Ltd. Atomizer and electronic cigarette comrpising the same
WO2023002191A1 (fr) * 2021-07-22 2023-01-26 Nicoventures Trading Limited Système de distribution comprenant un dispositif de génération d'aérosol et un matériau aérosolisable

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