WO2020080468A1 - Closure detection device and clamp unit - Google Patents

Closure detection device and clamp unit Download PDF

Info

Publication number
WO2020080468A1
WO2020080468A1 PCT/JP2019/040909 JP2019040909W WO2020080468A1 WO 2020080468 A1 WO2020080468 A1 WO 2020080468A1 JP 2019040909 W JP2019040909 W JP 2019040909W WO 2020080468 A1 WO2020080468 A1 WO 2020080468A1
Authority
WO
WIPO (PCT)
Prior art keywords
load
tube
unit
line
vein
Prior art date
Application number
PCT/JP2019/040909
Other languages
French (fr)
Japanese (ja)
Inventor
広行 ▲高▼畑
章吾 上戸
Original Assignee
株式会社ジェイ・エム・エス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社ジェイ・エム・エス filed Critical 株式会社ジェイ・エム・エス
Priority to CN201980058388.1A priority Critical patent/CN112654379B/en
Publication of WO2020080468A1 publication Critical patent/WO2020080468A1/en

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/28—Clamping means for squeezing flexible tubes, e.g. roller clamps
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
    • G01L7/00—Measuring the steady or quasi-steady pressure of a fluid or a fluent solid material by mechanical or fluid pressure-sensitive elements

Definitions

  • the present invention relates to a blockage detection device and a clamp unit.
  • a blockage detection device including a unit body, a lid portion that opens and closes the unit body, and a load detection sensor that detects a load due to pressure from a tube is known (for example, see Patent Document 1).
  • the load detection sensor will be damaged if a certain load is applied. Therefore, it is desired that the load detection sensor can be restrained from being applied with a load of a predetermined value or more.
  • An object of the present invention is to provide a blockage detection device and a clamp unit capable of suppressing a load of a predetermined value or more from being applied to a load detection sensor that detects a load due to pressure from a tube.
  • the present invention provides a unit main body, a substrate attached to the unit main body, a load detection sensor disposed on the substrate for detecting a load due to pressure from a tube, a lid portion for opening and closing the unit main body, and the lid.
  • a load detection sensor disposed on the substrate for detecting a load due to pressure from a tube
  • a lid portion for opening and closing the unit main body, and the lid.
  • the load absorbing portion is a rod-shaped guide member that is arranged to penetrate the substrate in the thickness direction and movably supports the substrate in the thickness direction, and a load of a predetermined value or more is applied to the load detection sensor.
  • the load detection sensor receives a load less than a predetermined value while allowing the movement of the substrate to the side that absorbs the load applied to the load detection sensor, the load detection sensor is located at the detection position.
  • a biasing member that biases the substrate so as to do so.
  • the biasing member is composed of two spring members, two guide members are provided, and two sets of the spring member and the guide member are provided with the spring member and the guide member as one set. It is preferable that the load detection sensor is arranged at two positions in the plane direction of the substrate with the portion where the load detection sensor is arranged sandwiched therebetween.
  • the load absorbing portion further includes a connecting member that connects the two guide members.
  • the present invention also relates to a clamp unit that includes the blockage detection device and clamps the tube by disposing the tube between the unit body and the lid.
  • a blockage detection device and a clamp unit capable of suppressing a load of a predetermined value or more from being applied to a load detection sensor that detects a load due to pressure from a tube.
  • FIG. 5 is a sectional view taken along the line AA in FIG. 4.
  • FIG. 5 is a sectional view taken along line BB in FIG. 4. It is sectional drawing which shows the structure of a load detection part.
  • the hemodialysis apparatus of the present invention purifies blood of patients with renal failure and drug poisoning, removes excess water in the blood, and supplements (replenishes) water in the blood as necessary.
  • the hemodialyzer 1 as a dialyzer includes a dialyzer 10 as a hemodialyzer, a blood circuit 20, a dialysate circuit 30, a replenisher line 38, and a console 100.
  • the console 100 is provided with an operation panel 70, a clamp unit 60, a part of the blood circuit 20, a part of the dialysate circuit 30, a heater 40 as a temperature control unit, a drug solution pump 231, a replacement fluid pump 39, and a control device 50. Has been done.
  • the dialyzer 10 includes a container body 11 formed in a tubular shape and a dialysis membrane (not shown) housed inside the container body 11. And a dialysate-side flow path (both not shown).
  • the container body 11 is formed with a blood inlet 111 and a blood outlet 112 that communicate with the blood-side channel, and a dialysate inlet 113 and a dialysate outlet 114 that communicate with the dialysate-side channel.
  • the blood circuit 20 includes an artery side line 21, a vein side line 22, a drug line 23, and an overflow line 24.
  • the arterial side line 21, the vein side line 22, the drug line 23, and the overflow line 24 are each mainly configured by a flexible tube through which a liquid can flow.
  • the tubes forming the artery side line 21, the vein side line 22, the drug line 23, and the overflow line 24 are flexible tubes such as polyvinyl chloride (PVC) and silicon (Si). It is formed.
  • PVC polyvinyl chloride
  • Si silicon
  • the tube for example, a tube having an outer diameter of 5.5 mm and an inner diameter of 3.3 mm is used.
  • the tube has a hardness of, for example, about 50 to 85 (JIS K7215).
  • the arterial line 21 has one end connected to the artery of the subject (dialysis patient) and the other end connected to the blood inlet 111 of the dialyzer 10.
  • the console 100 is arranged in the middle of the artery side line 21.
  • the clamp unit 60 and the blood pump 212 are arranged in a portion where the artery side line 21 passes.
  • An arterial side clamp section (clamp section) 65, a load detection section 66, and an arterial side bubble sensor (bubble detection section) 67 are arranged in a portion of the clamp unit 60 through which the artery side line 21 passes. Details of the clamp unit 60 will be described later.
  • Blood pump 212 is arranged downstream of clamp unit 60 in arterial line 21.
  • the blood pump 212 squeezes the tube that constitutes the artery-side line 21 with a roller, and thereby delivers the liquid such as blood and priming fluid inside the artery-side line 21.
  • the vein side line 22 has one end connected to the blood outlet 112 of the dialyzer 10 and the other end connected to the vein of the subject (dialysis patient).
  • the vein side chamber 222 and the console 100 are arranged in the middle of the vein side line 22 in the middle of the vein side line 22 .
  • the clamp unit 60 is arranged at a portion where the vein side line 22 passes.
  • a vein side clamp portion 69 and a vein side bubble sensor 68 are arranged in a portion of the clamp unit 60 through which the vein side line 22 passes. Details of the clamp unit 60 will be described later.
  • the vein side chamber 222 is arranged between the dialyzer 10 and the console 100 in the vein side line 22.
  • the vein side chamber 222 stores a predetermined amount (for example, 20 ml) of blood.
  • the drug line 23 supplies the drug required during hemodialysis to the arterial line 21.
  • One end side (proximal end side) of the drug line 23 is connected to a drug solution pump 231 that delivers a drug, and the other end side (tip end side) is connected between the blood pump 212 and the dialyzer 10 in the arterial side line 21.
  • the overflow line 24 has one end side (base end side) connected to the vein side chamber 222.
  • the overflow line 24 discharges the physiological saline solution, air and the like flowing through the vein side line 22 to the outside in the priming process.
  • An overflow clamp 241 is arranged in the overflow line 24. The overflow clamp 241 opens and closes the flow path of the overflow line 24.
  • the blood extracted from the artery of the subject flows through the artery side line 21 by the blood pump 212 and is introduced into the blood side flow path of the dialyzer 10.
  • the blood introduced into the dialyzer 10 is purified by the dialysate flowing through the dialysate circuit 30 described later through the dialyzing membrane.
  • the blood purified by the dialyzer 10 flows through the vein side line 22 and is returned to the vein of the subject.
  • the dialysate circuit 30 is composed of a so-called closed capacity control type dialysate circuit 30.
  • the dialysate circuit 30 includes a dialysate chamber 31, a dialysate supply line 32, a dialysate introduction line 33, a dialysate outlet line 34, a drain line 35, a bypass line 36, and water removal / reverse filtration. And a pump 37.
  • the dialysate chamber 31 includes a hard container 311 that can store a fixed volume (for example, 300 ml to 500 ml) of dialysate, and a soft diaphragm (diaphragm) 312 that partitions the interior of the container 311.
  • the interior of the dialysate chamber 31 is partitioned by a diaphragm 312 into a liquid feed storage 313 and a drainage storage 314.
  • the dialysate supply line 32 has a proximal end connected to a dialysate supply device (not shown) and a distal end connected to the dialysate chamber 31.
  • the dialysate supply line 32 supplies the dialysate to the liquid delivery container 313 of the dialysate chamber 31.
  • the dialysate introduction line 33 connects the dialysate chamber 31 and the dialysate inlet 113 of the dialyzer 10, and connects the dialysate contained in the solution delivery container 313 of the dialysate chamber 31 to the dialysate-side flow path of the dialyzer 10.
  • the dialysate outlet line 34 connects the dialysate outlet 114 of the dialyzer 10 and the dialysate chamber 31, and leads the dialysate discharged from the dialyzer 10 to the drainage storage portion 314 of the dialysate chamber 31.
  • the drain line 35 is connected to the dialysate chamber 31 on the proximal end side and drains the drainage of the dialysate stored in the drainage container 314.
  • the bypass line 36 connects the dialysate outlet line 34 and the drain line 35.
  • the dewatering / back filtration pump 37 is arranged in the bypass line 36.
  • the water removal / reverse filtration pump 37 sends the dialysate inside the bypass line 36 to the drainage line 35 side (removal direction) and to the dialysate discharge line 34 side (reverse filtration direction). It is composed of a pump that drives liquid.
  • the heater 40 heats the dialysate flowing through the dialysate circuit 30 to a predetermined temperature.
  • the replenisher line 38 is a line for directly supplying the dialysate to the blood circuit 20. As shown in FIG. 1, the upstream side of the replenisher line 38 is connected between the dialysate chamber 31 in the dialysate introduction line 33 of the dialysate circuit 30 and the dialysate inlet 113 of the dialyzer 10.
  • the replenisher line 38 is provided with a replenisher clamp 381. As shown by the solid line in FIG. 1, when the downstream side of the replenisher line 38 is connected between the blood pump 212 and the dialyzer 10 in the arterial line 21, predilution type hemofiltration / dialysis is performed. Further, as shown by the broken line in FIG. 1, when the downstream side of the replenisher solution line 38 is connected to the vein side chamber 222 in the vein side line 22, the post-dilution type hemofiltration dialysis is performed.
  • the clamp unit 60 will be described. As shown in FIG. 1, the clamp unit 60 is configured as a unit and is attached to the console 100. The clamp unit 60 clamps and holds the tube forming the artery side line 21 and the tube forming the vein side line 22. In the clamp unit 60, on one side in the width direction H, the tubes forming the artery side line 21 are arranged in the vertical direction, and on the other side in the width direction H, the tubes forming the vein side line 22 are arranged in the vertical direction. It is arranged over.
  • the clamp unit 60 includes a unit body 61, a lid portion 62 that opens and closes the unit body 61, a hinge portion 63, an opening / closing lever 641, an opening / closing engagement portion 642, and a substrate 664. (See FIG. 5) and a load detection unit 66.
  • the clamp unit 60 fixes the tube by disposing the tube between the unit body 61 and the lid portion 62.
  • the clamp unit 60 is configured such that the inner surface of the unit main body 61 has the tubes forming the artery side line 21 and the tube forming the vein side line 22 arranged therein, and the inner surface of the unit main body 61 is pressed against the inner surface of the lid portion 62.
  • the tube forming the artery side line 21 and the tube forming the vein side line 22 are fixed.
  • the inner surface of the lid portion 62 forms a tube fixing portion that fixes the tube forming the artery side line 21 and the tube forming the vein side line 22 with a constant force.
  • a resin material is used as the material of at least the portion that presses the tube, and ABS resin (acrylonitrile-butadiene-styrene copolymer), ASA resin (butadiene resin of ABS resin) is used. In place of acrylic rubber), synthetic resins such as polypropylene, etc. are used. Accordingly, the inner surface of the lid portion 62 can be fixed with an appropriate holding force that sufficiently holds the tube forming the artery side line 21 and the tube forming the vein side line 22 and does not crush it too much.
  • the hinge portion 63 is arranged at the other end of the clamp unit 60 in the width direction H when the lid portion 62 is closed so that the lid portion 62 can rotate with respect to the unit body 61. Connecting.
  • the opening / closing lever 641 is provided at one end of the lid portion 62 on one side in the width direction H when the lid portion 62 is closed. As shown in FIG. 3, the opening / closing engagement portion 642 is provided at an end portion on one side in the width direction H of the inner surface of the unit body 61 so that the opening / closing lever 641 can be engaged when the lid portion 62 is closed. By operating the opening / closing lever 641, the unit body 61 and the lid 62 are opened / closed.
  • a main body side arterial tube placement section 611 (tube placement section) and a main body side vein side tube placement section 612 (tube placement section) are formed on the inner surface of the unit main body 61.
  • the main body side arterial tube placement section 611 and the main body side vein side tube placement section 612 are arranged on the inner surface of the unit main body 61 so as to be spaced apart in the width direction H of the unit main body 61 and extend linearly.
  • the main body side vein side tube placement portion 612 is placed closer to the hinge portion 63 side in the width direction H than the main body side arterial side tube placement portion 611.
  • a board 664 is attached to the outer surface 613 (see FIG. 8) of the unit main body 61.
  • a force sensor 665 (load detection sensor) of the load detection unit 66 is mounted (disposed) on the first surface 664a (see FIG. 8) of the board 664 on the unit body 61 side (see FIG. 8 described later).
  • the lid portion side arterial tube placement portion 621 that is placed to face the main body side arterial side tube placement portion 611, and the main body side A lid side vein side tube placement portion 622, which is placed so as to face the vein side tube placement portion 612, is formed.
  • the lid side arterial tube placement section 621 and the lid side vein side tube placement section 622 are arranged on the inner surface of the lid section 62 so as to be separated from each other in the width direction H of the lid section 62 and extend linearly.
  • the lid side vein side tube placement portion 622 is placed closer to the hinge portion 63 side in the width direction H than the lid side artery side tube placement portion 621.
  • the tube forming the artery side line 21 is arranged between the main body side arterial tube placement section 611 and the lid side arterial side tube placement section 621, and the main body side vein side tube placement is arranged.
  • the tube forming the vein side line 22 is arranged between the portion 612 and the lid side vein side tube placement portion 622.
  • the configuration provided in the main body side arterial tube placement section 611 and the lid side arterial side tube placement section 621 will be described.
  • FIG. 3 and FIG. 6 when the lid 62 is closed, the arterial upstream tube retainer 601 and the artery side along the main body side arterial tube placement part 611 and the lid side arterial side tube placement part 621.
  • a clamp part 65, a load detection part 66, an artery side air bubble sensor 67 and an artery side downstream tube pressing part 602 are arranged.
  • the artery-side upstream tube pressing portion 601, the artery-side clamping portion 65, the load detecting portion 66, the artery-side bubble sensor 67, and the artery-side downstream tube pressing portion 602 are arranged in the clamp unit 60 from the upstream side to the downstream side. They are arranged side by side in this order from the lower side to the upper side in FIGS. 1 and 3.
  • the main body side artery side tube placement portion 611 is placed on the inner surface of the unit main body 61 as shown in FIG.
  • the arterial side upstream tube holding section is arranged in order from the upstream side to the downstream side (from the lower side to the upper side in FIG. 3) of the liquid flowing through the tube forming the artery side line 21.
  • An arterial-side bubble sensor in which an accommodating recess 601a of 601, an arterial-side movable clamp part 651 of the arterial-side clamp part 65, a load receiving part 662 of the load detecting part 66, and an ultrasonic wave oscillating part 671 of the arterial-side bubble sensor 67 are accommodated inside.
  • the receiving member 672 and the accommodating recess 602a of the artery-side downstream tube pressing portion 602 are arranged side by side.
  • the lid-side artery-side tube placement portion 621 is placed on the inner surface of the lid portion 62, and is placed so as to face the main-body-side artery-side tube placement portion 611 when the lid portion 62 is closed.
  • the lid-side artery-side tube placement portion 621 sequentially holds the arterial-side upstream tube retainer from the upstream side to the downstream side (from the lower side to the upper side in FIG. 3) of the liquid flowing through the tube forming the artery-side line 21.
  • the pressing convex portion 601b of the artery-side upstream tube pressing portion 601 is arranged so as to face the accommodating concave portion 601a arranged in the unit main body 61 when the lid portion 62 is closed, and the liquid flowing through the artery-side line 21 in the clamp unit 60.
  • the tube forming the artery side line 21 is pressed.
  • the artery-side clamp receiving portion 652 is arranged so as to face the artery-side movable clamp portion 651 arranged in the unit main body 61 when the lid portion 62 is closed.
  • the artery-side clamp receiving portion 652 and the artery-side movable clamp portion 651 constitute the artery-side clamp portion 65, and hold the tube constituting the artery-side line 21 by sandwiching it.
  • the artery-side clamp portion 65 includes an artery-side movable clamp portion 651 arranged in the unit body 61, and a solenoid 653 arranged in the unit body 61 and driving the artery-side movable clamp portion 651. , And an artery-side clamp receiving portion 652 arranged on the lid portion 62.
  • the artery-side clamp receiving portion 652 is formed so as to project from the inner surface of the lid portion 62 and extends in the width direction H.
  • the arterial-side movable clamp portion 651 has a distal end formed in a flat shape extending in the width direction H, and a trapezoid shape in which the width on the distal end side is narrow in a cross section cut in the extending direction of the tube placement portion. To be done.
  • An output shaft 653a of a solenoid 653 is connected to the rear end of the artery-side movable clamp portion 651 so as to be able to move forward and backward.
  • the arterial-side movable clamp section 651 clamps the tube forming the arterial-side line 21 by sandwiching the tube forming the arterial-side line 21 between the tip of the arterial-side clamp section 651 and the tip of the arterial-side clamp receiving section 652 by advancing and retracting the output shaft 653a of the solenoid 653.
  • the artery side line 21 is opened and closed.
  • the arterial side clamp part 65 configured as described above is arranged between the unit main body 61 and the lid part 62 by the arterial side movable clamp part 651 and the arterial side clamp receiving part 652 during the normal operation of the hemodialysis apparatus 1.
  • the tube forming the arterial line 21 to be clamped is clamped.
  • the arterial side clamp portion 65 is opened and closed in the priming and blood returning process using physiological saline.
  • the arterial side clamp part 65 moves the arterial side movable clamp part 651 forwards and backwards to crush and open the tube forming the arterial side line 21 and open and close the flow path of the arterial side line 21.
  • On the upstream side of 67 the flow of the liquid flowing through the inside of the tube is made to flow / stop.
  • the load detection unit 66 can detect the load due to the pressure from the tube forming the artery side line 21 and output it as a voltage value. That is, when the tube is closed, the pressure in the tube becomes positive pressure or negative pressure, the radial direction of the tube changes, and the load changes with it, and as a result, it is detected as a change in voltage value.
  • the load detector 66 includes a load retainer 663, a load receiver 662, a force sensor 665 arranged on the substrate 664, and a load absorber 80.
  • the load detection unit 66 constitutes a blockage detection device.
  • the load holding portion 663 is arranged to face the load receiving portion 662 arranged in the unit main body 61 when the lid portion 62 is closed, and constitutes the artery side line 21. Hold down the tube.
  • the load holding unit 663 may have a height-adjustable configuration so that when the diameter of the tube is changed, the voltage values output from the load detecting unit 66 can be similar voltage values. Alternatively, the load holding portions having different heights may be exchangeable.
  • the load receiving portion 662 receives the load due to the pressure from the tube forming the artery side line 21 which is held by the load holding portion 663 when the lid 62 is closed.
  • the load receiving portion 662 transmits the load to the force sensor 665 arranged on the substrate 664.
  • the load receiving portion 662 has a surface sheet portion 662a, a pressing portion 662b, and a transmission shaft portion 662c.
  • the surface sheet portion 662a is arranged on the tube side and is brought into contact with the tube forming the artery side line 21 when the lid portion 62 is closed.
  • the pressing portion 662b and the transmission shaft portion 662c are arranged in the communication hole 615 of the unit body 61.
  • the communication hole 615 communicates with the inner surface of the unit body 61 and the outer surface 613.
  • the surface sheet portion 662a, the pressing portion 662b, and the transmission shaft portion 662c are arranged in this order from the inner surface side of the unit body 61 toward the outer surface 613 side.
  • the force sensor 665 is mounted (disposed) on the first surface 664 a formed on the unit body 61 side of the board 664.
  • the substrate 664 is attached to the outer surface 613 of the unit body 61.
  • the board 664 is arranged so as to close the communication hole 615 and intersect with the direction in which the communication hole 615 extends.
  • the first surface 664a on the unit body 61 side is brought into contact with the outer surface 613 of the unit body 61, and the second surface 664b on the side opposite to the first surface 664a is formed by two spring members 82 and 82 described later. It is pressed toward the unit body 61 side.
  • the force sensor 665 is arranged on the extension line of the communication hole 615 on the outer surface 613 side of the unit main body 61.
  • the load receiving portion 662 is arranged in the communication hole 615 as described above.
  • the artery side line 21 is provided between the load holding portion 663 and the force sensor 665 of the lid portion 62 from the load holding portion 663 side toward the force sensor 665 side.
  • the constituent tubes and the load receiving portion 662 are arranged in this order.
  • the force sensor 665 configured as described above moves from the tube via the load receiving portion 662 as the load receiving portion 662 moves in the radial direction of the tube due to the pressure applied from the tube to the load receiving portion 662.
  • the load due to the pressure of is detected. Accordingly, the force sensor 665 outputs the load due to the pressure of the tube forming the artery side line 21 as a voltage.
  • the load absorbing unit 80 is arranged on the substrate 664 as shown in FIG. In the state where the lid body 62 closes the unit main body 61 and the tube is arranged between the lid portion 62 and the force sensor 665, the load absorbing portion 80 applies a load equal to or more than the allowable load (more than a predetermined value) to the force sensor 665. When applied, it absorbs the load applied to the substrate 664 via the force sensor 665.
  • the load absorbing portion 80 includes two guide posts 81 and 81 (guide members), two spring members 82 and 82 (biasing members), and a connecting member 83 that connects the spring members 82 and 82.
  • the guide post 81 and the spring member 82 are configured with the guide post 81 and the spring member 82 as one set, and in the present embodiment, two sets of the guide post 81 and the spring member 82 are provided.
  • the two sets of the guide post 81 and the spring member 82 are arranged apart from each other in the plane direction of the substrate 664 at two positions sandwiching the portion where the force sensor 665 is arranged.
  • Each of the two guide posts 81, 81 is formed in a cylindrical rod shape and extends in the thickness direction of the substrate 664.
  • the guide post 81 is arranged to penetrate the substrate 664 in the thickness direction and supports the substrate 664 so as to be movable in the thickness direction.
  • the two guide posts 81, 81 are arranged apart from each other in the width direction H of the clamp unit 60.
  • One end side of each of the two guide posts 81, 81 is inserted and fixed in a mounting hole 616 formed in the outer surface 613 of the unit body 61, and the other end side thereof projects from the outer surface 613 of the unit body 61.
  • the two mounting holes 616 are formed to extend in parallel with the communication hole 615, and are arranged in the width direction H of the clamp unit 60 so as to sandwich the communication hole 615 in the surface direction of the substrate 664.
  • the connecting member 83 is formed in a plate shape extending in the width direction H of the clamp unit 60.
  • the connecting member 83 connects the ends of the two guide posts 81, 81 on the other end side. Both ends of the connecting member 83 are fixed to the other end of the guide post 81 by screws 811.
  • the two spring members 82, 82 are each formed in a coil shape to be mounted on the guide post 81.
  • the spring member 82 is arranged so as to be capable of expanding and contracting between the second surface 664b of the substrate 664 and the connecting member 83.
  • the spring member 82 allows the force sensor 665 to move to a side that absorbs the load applied to the force sensor 665 when the load applied to the force sensor 665 is greater than the allowable load, and the force sensor 665 has a load less than the allowable load.
  • the substrate 664 is urged so that the force sensor 665 is located at the detection position.
  • the force sensor 665 when the force sensor 665 is applied with a load equal to or larger than the allowable load, the force sensor 665 is allowed to move toward the side that absorbs the load applied to the force sensor 665. It is possible to suppress the above load.
  • the spring constant of the spring member 82 is not reduced when the force sensor 665 is applied with a load less than the allowable load, and is reduced only when the force sensor 665 is applied with a load equal to or greater than the allowable load. Value is set.
  • the force sensor 665 when the tube is arranged in the clamp unit 60, when the tube is arranged between the unit main body 61 and the lid portion 62, the force sensor 665 has a load larger than the allowable load.
  • the spring member 82 can absorb the load in the thickness direction of the substrate 664. Therefore, it is possible to prevent the force sensor 665 from being applied with a load equal to or more than the allowable load (equal to or more than a predetermined value). Therefore, damage to the force sensor 665 can be prevented.
  • the spring member 82 of the load absorbing section 80 does not shrink. That is, in a normal use state, the spring member 82 of the load absorbing portion 80 is held so that the force sensor 665 is located at the detection position without being contracted. Therefore, the force sensor 665 applies the load due to the pressure from the tube. Can be normally detected. Accordingly, the load absorbing unit 80 does not affect the detection of the load due to the pressure from the tube by the force sensor 665 in the normal use state.
  • the lid portion 62 presses the tube forming the artery side line 21 toward the force sensor 665 side, so that the force sensor 665 presses the pressure from the tube.
  • the load is detected and the load is output as a voltage value.
  • the detection value detected by the load detection unit 66 is transmitted to the control device 50, and it is determined whether or not the tube is closed. Examples of the case where the tube is blocked include, for example, forgetting to remove the forceps after connecting the blood circuit, clogging of the needle tip due to a thrombus when returning blood during treatment, and blood vessel wall of the needle tip during blood removal / dialysis. And the lack of blood flow due to blood vessel conditions during blood removal / dialysis / returning blood.
  • the arterial-side bubble sensor pressing member 674 is arranged so as to face the arterial-side bubble sensor receiving member 672 arranged in the unit main body 61 when the lid 62 is closed. Hold down the tubes that make up the line 21.
  • An ultrasonic wave reception unit 673 is arranged inside the artery-side bubble sensor holding member 674.
  • An ultrasonic oscillator 671 is arranged inside the arterial bubble sensor receiving member 672.
  • the ultrasonic wave receiving unit 673 and the ultrasonic wave oscillating unit 671 form an artery side air bubble sensor 67.
  • the arterial bubble sensor 67 is a sensor that detects the presence or absence of bubbles contained in the liquid flowing inside the artery line 21.
  • the ultrasonic wave receiving unit 673 may be arranged inside the artery-side bubble sensor receiving member 672, and the ultrasonic wave oscillating unit 671 may be arranged inside the artery-side bubble sensor holding member 674.
  • the arterial bubble sensor pressing member 674 presses the tube forming the arterial line 21 against the arterial bubble sensor receiving member 672.
  • the ultrasonic wave receiving unit 673 detects the difference in the transmittance between the liquid and the bubbles by irradiating the liquid flowing in the tube forming the artery side line 21 with the ultrasonic wave generated from the ultrasonic wave oscillating unit 671. Detects the presence of bubbles.
  • the pressing convex portion 602b of the artery-side downstream tube pressing portion 602 is arranged so as to face the accommodating concave portion 602a arranged in the unit main body 61 when the lid portion 62 is closed, and circulates through the artery-side line 21 in the clamp unit 60. On the downstream side (upper side in FIG. 3) of the liquid, the tube forming the artery side line 21 is pressed.
  • the vein side upstream tube pressing portion 603 and the vein side air bubble sensor 68 are arranged along the main body side vein side tube placement portion 612 and the lid side vein side tube placement portion 622.
  • the vein side clamp section 69 and the vein side downstream tube holding section 604 are arranged.
  • the vein-side upstream tube pressing portion 603, the vein-side bubble sensor 68, the vein-side clamping portion 69, and the vein-side downstream tube pressing portion 604 are arranged in the clamp unit 60 from the upstream side to the downstream side (FIG. 1 and FIG. 1). 3 are arranged in this order from the upper side to the lower side).
  • the main body side vein side tube arrangement portion 612 is arranged on the inner surface of the unit main body 61 as shown in FIG.
  • the main body side venous tube placement section 612 has a venous side upstream tube holding section in order from the upstream side to the downstream side (from the upper side to the lower side in FIG. 3) of the liquid flowing through the tube forming the vein side line 22.
  • the accommodation recesses 604a of 604 are arranged side by side.
  • the lid-side vein-side tube placement portion 622 is placed on the inner surface of the lid portion 62, and is placed so as to face the main-body-side vein-side tube placement portion 612 when the lid portion 62 is closed.
  • the lid-side vein-side tube placement portion 622 sequentially holds the vein-side upstream tube holder from the upstream side to the downstream side (from the upper side to the lower side in FIG. 3) of the liquid flowing through the tube forming the vein side line 22.
  • the pressing protrusions 604b of the pressing portion 604 are arranged side by side.
  • the holding convex portion 603b of the vein side upstream tube holding portion 603 is arranged so as to face the housing concave portion 603a arranged in the unit main body 61 when the lid portion 62 is closed, and the liquid flowing through the vein side line 22 in the clamp unit 60.
  • the tube forming the vein side line 22 is pressed.
  • the vein-side bubble sensor pressing member 684 is arranged so as to face the vein-side bubble sensor receiving member 682 arranged in the unit main body 61 when the lid 62 is closed, and presses the tube forming the vein-side line 22.
  • An ultrasonic wave receiving unit 683 is arranged inside the vein-side bubble sensor holding member 684.
  • An ultrasonic wave oscillating unit 681 is arranged inside the vein-side bubble sensor receiving member 682.
  • the ultrasonic wave receiving unit 683 and the ultrasonic wave oscillating unit 681 form a vein side bubble sensor 68.
  • the vein-side bubble sensor 68 is a sensor that detects the presence or absence of bubbles contained in the liquid flowing through the inside of the vein-side line 22.
  • the ultrasonic wave receiving unit 683 may be arranged inside the vein side bubble sensor receiving member 682, and the ultrasonic wave generating unit 681 may be arranged inside the vein side bubble sensor receiving member 684.
  • the vein side bubble sensor pressing member 684 presses the tube forming the vein side line 22 against the vein side bubble sensor receiving member 682 side.
  • the ultrasonic wave receiving unit 683 detects the difference in the transmittance between the liquid and the bubbles by irradiating the liquid flowing in the tube forming the vein side line 22 with the ultrasonic wave generated from the ultrasonic wave oscillating unit 681. Detects the presence of bubbles.
  • the vein side clamp receiving portion 692 is arranged to face the vein side movable clamp portion 691 arranged in the unit main body 61 when the lid portion 62 is closed.
  • the vein side clamp receiving portion 692 and the vein side movable clamp portion 691 form the vein side clamp portion 69, and hold the tube forming the vein side line 22 by sandwiching the tube.
  • the vein side clamp part 69 includes a vein side movable clamp part 691 arranged in the unit main body 61, and a solenoid 693 arranged in the unit main body 61 and driving the vein side movable clamp part 691. , And a vein-side clamp receiving portion 692 arranged on the lid portion 62.
  • the vein side clamp receiving portion 692 is formed to project from the inner surface of the lid portion 62 and extends in the width direction H.
  • the venous side movable clamp portion 691 has a tip end formed in a flat shape extending in the width direction H and a trapezoid shape having a narrow width on the tip end side in a cross section cut in the direction in which the tube placement portion extends.
  • An output shaft 693a of a solenoid 693 is connected to the rear end of the vein side movable clamp portion 691 so as to be able to move forward and backward.
  • the vein side movable clamp section 691 clamps the tube forming the vein side line 22 by sandwiching the tube forming the vein side line 22 between the tip of the vein side movable clamp section 691 and the tip of the vein side clamp receiving section 692 by advancing and retracting the output shaft 693a of the solenoid 693.
  • the vein side line 22 is opened and closed.
  • the vein side clamp part 69 configured as described above is disposed between the unit main body 61 and the lid part 62 by the vein side movable clamp part 691 and the vein side clamp receiving part 692 during the normal operation of the hemodialysis apparatus 1.
  • the tube forming the venous line 22 is clamped. Further, the vein side clamp section 69 is controlled according to the detection result of the bubble by the vein side bubble sensor 68 or the artery side bubble sensor 67.
  • the venous side clamp portion 69 configures the venous side line 22 by advancing the venous side movable clamp portion 691 when the venous side bubble sensor 68 or the arterial side bubble sensor 67 detects more bubbles than a predetermined amount. By crushing the tube and closing the flow path of the venous line 22, the liquid supply flowing through the inside of the tube is stopped on the upstream side of the venous bubble sensor 68.
  • the pressing convex portion 604b of the vein side downstream tube pressing portion 604 is arranged so as to face the accommodation concave portion 604a arranged in the unit main body 61 when the lid portion 62 is closed, and circulates through the vein side line 22 in the clamp unit 60. On the downstream side (lower side in FIG. 3) of the liquid, the tube forming the vein side line 22 is pressed.
  • the clamp unit 60 configured as described above is configured such that the tube forming the artery side line 21 and the tube forming the vein side line 22 are arranged in the unit main body 61, and the lid portion 62 is simply closed. The tube can be securely clamped at 60.
  • the control device 50 is composed of an information processing device (computer), and controls the operation of the dialysis device 1 by executing a control program.
  • the control device 50 controls the operation of the hemodialysis device 1 to operate by executing control programs for various processes. Specifically, the control device 50 controls the operations of various pumps and clamps arranged in the blood circuit 20 and the dialysate circuit 30, the heater 40, and the like to perform various steps (priming) performed by the hemodialysis device 1. Process, blood removal process, dialysis process, fluid replacement process, blood return process, etc.).
  • the load detection unit 66 is provided with the unit main body 61, the substrate 664 attached to the unit main body 61, the force sensor 665 arranged on the substrate 664 to detect the load due to the pressure from the tube, and the unit main body 61 is opened and closed.
  • a load equal to or larger than a predetermined value is applied to the force sensor 665 in a state in which the unit body 61 is closed by the lid unit 62 and the tube is arranged between the lid unit 62 and the force sensor 665, And a load absorbing section 80 that absorbs the load applied to the substrate 664 via the force sensor 665.
  • the tube is arranged between the unit body 61 and the lid portion 62, it is possible to prevent the force sensor 665 from being applied with a load larger than the allowable load. Therefore, when a load less than the allowable load is applied to the substrate 664, the force sensor 665 can be prevented from being applied with a load larger than the allowable load without affecting the detection of the load of the force sensor 665 due to the pressure from the tube. . As a result, damage to the force sensor 665 can be suppressed.
  • the load absorbing portion 80 has a rod-shaped guide post 81 that is arranged to penetrate the substrate 664 in the thickness direction and supports the substrate 664 so as to be movable in the thickness direction, and a force sensor 665 that applies a load of a predetermined value or more. When the load applied to the force sensor 665 is less than a predetermined value, the force sensor 665 is positioned at the detection position while allowing the substrate 664 to move to the side that absorbs the load applied to the force sensor 665 when applied. And a spring member 82 for urging the substrate 664.
  • the load from the spring member 82 in the thickness direction of the substrate 664 is guided by the guide post 81 so that the substrate 664 can move in the thickness direction. Can be absorbed. This makes it possible to absorb the load applied to the force sensor 665 with a simple configuration.
  • the two sets of spring members 82 and guide posts 81 are arranged at two positions in the plane direction of the substrate 664, sandwiching the part where the force sensor 665 is arranged.
  • the load in the thickness direction of the substrate 664 can be absorbed by the two sets of the spring member 82 and the guide post 81 at two positions sandwiching the force sensor 665. Therefore, the load applied to the force sensor 665 can be stably absorbed.
  • the load absorbing portion 80 further includes a connecting member 83 that connects the two guide posts 81.
  • the two guide posts 81 can be kept parallel to each other, and the substrate 644 guided by the two guide posts 81 can be smoothly moved in the thickness direction. Thereby, the load applied to the force sensor 665 can be stably absorbed.
  • the present invention is not limited to the above-described embodiments and can be modified as appropriate.
  • the guide post 81 (guide member) and the spring member 82 (biasing member) are configured in two sets, but the configuration is not limited to this, and one set or three or more sets may be configured. .
  • connection member 83 is configured to connect the two guide posts 81, but the connection member 83 may not be provided.
  • the board 644 on which the force sensor 665 (load detection sensor) is mounted is arranged on the outer surface of the unit body 61, but the invention is not limited to this.
  • a recessed portion may be formed on the inner surface of the unit body 61, and the substrate 644 on which the force sensor 665 (load detection sensor) is mounted may be arranged in the recessed portion on the inner surface of the unit body 61.
  • Hemodialysis machine (dialysis machine) 61 unit main body 62 lid 66 load detector (blockage detector) 80 load absorbing part 81 guide post (guide member) 82 Spring member (biasing member) 83 connection member 664 substrate 665 force sensor (load detection sensor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • External Artificial Organs (AREA)

Abstract

The present invention provides a closure detection device and a clamp unit that can suppress application of a load with a predetermined value or more to a load detection sensor for detecting a load based on pressure from a tube. A closure detection device 66 is provided with: a unit body 61; a substrate 664 mounted to the unit body 61; a load detection sensor 665 that is disposed on the substrate 664 and detects a load based on pressure from a tube; a lid part 62 that opens/closes the unit body 61; a load absorption part 80 that, in a state where the unit body 61 is closed by the lid part 62 and the tube is disposed between the lid part 62 and the load detection sensor 665, when a load with a predetermined value or more is applied to the load detection sensor 665, absorbs a load applied to the substrate 664 via the load detection sensor 665.

Description

閉塞検知装置及びクランプユニットBlockage detection device and clamp unit
　本発明は、閉塞検知装置及びクランプユニットに関する。 The present invention relates to a blockage detection device and a clamp unit.
　従来、ユニット本体と、ユニット本体を開閉する蓋部と、チューブからの圧力による荷重を検出する荷重検出センサと、を備える閉塞検知装置が知られている（例えば、特許文献１参照）。 Conventionally, a blockage detection device including a unit body, a lid portion that opens and closes the unit body, and a load detection sensor that detects a load due to pressure from a tube is known (for example, see Patent Document 1).
特開２０１４－８３０９１号公報JP, 2014-83091, A
　荷重検出センサは、一定以上の荷重が掛かると破損してしまう。そのため、荷重検出センサに所定値以上の荷重が掛かることを抑制できることが望まれる。 The load detection sensor will be damaged if a certain load is applied. Therefore, it is desired that the load detection sensor can be restrained from being applied with a load of a predetermined value or more.
　本発明は、チューブからの圧力による荷重を検出する荷重検出センサに所定値以上の荷重が掛かることを抑制できる閉塞検知装置及びクランプユニットを提供することを目的とする。 An object of the present invention is to provide a blockage detection device and a clamp unit capable of suppressing a load of a predetermined value or more from being applied to a load detection sensor that detects a load due to pressure from a tube.
　本発明は、ユニット本体と、前記ユニット本体に取り付けられた基板と、前記基板に配置され、チューブからの圧力による荷重を検出する荷重検出センサと、前記ユニット本体を開閉する蓋部と、前記蓋部により前記ユニット本体を閉じて前記蓋部と前記荷重検出センサとの間に前記チューブが配置された状態において、前記荷重検出センサに所定値以上の荷重が掛かった場合に、荷重検出センサを介して前記基板に掛かった荷重を吸収する荷重吸収部と、を備える閉塞検知装置に関する。 The present invention provides a unit main body, a substrate attached to the unit main body, a load detection sensor disposed on the substrate for detecting a load due to pressure from a tube, a lid portion for opening and closing the unit main body, and the lid. In a state where the unit main body is closed by a section and the tube is arranged between the lid section and the load detection sensor, when a load of a predetermined value or more is applied to the load detection sensor, the load detection sensor is used. And a load absorbing section for absorbing a load applied to the substrate.
　また、前記荷重吸収部は、前記基板を厚さ方向に貫通して配置され前記基板を厚さ方向に移動可能に支持する棒状のガイド部材と、前記荷重検出センサに所定値以上の荷重が掛かった場合に前記荷重検出センサに掛かった荷重を吸収する側への前記基板の移動を許容しつつ、前記荷重検出センサに所定値未満の荷重が掛かった場合に前記荷重検出センサが検出位置に位置するように前記基板を付勢する付勢部材と、を有することが好ましい。 In addition, the load absorbing portion is a rod-shaped guide member that is arranged to penetrate the substrate in the thickness direction and movably supports the substrate in the thickness direction, and a load of a predetermined value or more is applied to the load detection sensor. When the load detection sensor receives a load less than a predetermined value while allowing the movement of the substrate to the side that absorbs the load applied to the load detection sensor, the load detection sensor is located at the detection position. And a biasing member that biases the substrate so as to do so.
　また、前記付勢部材は、２つのバネ部材で構成され、前記ガイド部材は、２つ設けられ、前記バネ部材及び前記ガイド部材を１組として、２組の前記バネ部材及び前記ガイド部材は、前記基板の面方向における前記荷重検出センサが配置された部分を挟んだ２箇所に配置されることが好ましい。 Further, the biasing member is composed of two spring members, two guide members are provided, and two sets of the spring member and the guide member are provided with the spring member and the guide member as one set. It is preferable that the load detection sensor is arranged at two positions in the plane direction of the substrate with the portion where the load detection sensor is arranged sandwiched therebetween.
　また、前記荷重吸収部は、前記２つのガイド部材を接続する接続部材を更に有することが好ましい。 Moreover, it is preferable that the load absorbing portion further includes a connecting member that connects the two guide members.
　また、本発明は、前記の閉塞検知装置を備え、前記ユニット本体と前記蓋部との間にチューブを配置することでチューブをクランプするクランプユニットに関する。 The present invention also relates to a clamp unit that includes the blockage detection device and clamps the tube by disposing the tube between the unit body and the lid.
　本発明によれば、チューブからの圧力による荷重を検出する荷重検出センサに所定値以上の荷重が掛かることを抑制できる閉塞検知装置及びクランプユニットを提供することができる。 According to the present invention, it is possible to provide a blockage detection device and a clamp unit capable of suppressing a load of a predetermined value or more from being applied to a load detection sensor that detects a load due to pressure from a tube.
本発明の一実施形態に係る血液透析装置の全体構成を示す図である。It is a figure showing the whole hemodialysis machine composition concerning one embodiment of the present invention. クランプユニットの構成を示す正面図である。It is a front view which shows the structure of a clamp unit. クランプユニットの開状態を示す図である。It is a figure which shows the open state of a clamp unit. クランプユニットの閉鎖状態を示す斜視図である。It is a perspective view which shows the closed state of a clamp unit. クランプユニットを下方側から視た斜視図である。It is the perspective view which looked the clamp unit from the lower side. 図４におけるＡ－Ａ線断面図である。FIG. 5 is a sectional view taken along the line AA in FIG. 4. 図４におけるＢ－Ｂ線断面図である。FIG. 5 is a sectional view taken along line BB in FIG. 4. 荷重検出部の構成を示す断面図である。It is sectional drawing which shows the structure of a load detection part.
　以下、本発明のクランプユニット６０を含む血液透析装置の好ましい一実施形態について、図面を参照しながら説明する。本発明の血液透析装置は、腎不全患者や薬物中毒患者の血液を浄化すると共に、血液中の余分な水分を除去し、必要に応じて血液中に水分を補充（補液）する。
　まず、本実施形態の血液透析装置１の全体構成につき、図１を参照しながら説明する。透析装置としての血液透析装置１は、血液透析器としてのダイアライザ１０と、血液回路２０と、透析液回路３０と、補充液ライン３８と、コンソール１００と、を備える。コンソール１００には、操作パネル７０、クランプユニット６０、血液回路２０の一部、透析液回路３０の一部、温度調節部としてのヒータ４０、薬液ポンプ２３１、補液ポンプ３９、及び制御装置５０が配置されている。 Hereinafter, a preferred embodiment of a hemodialysis apparatus including the clamp unit 60 of the present invention will be described with reference to the drawings. INDUSTRIAL APPLICABILITY The hemodialysis apparatus of the present invention purifies blood of patients with renal failure and drug poisoning, removes excess water in the blood, and supplements (replenishes) water in the blood as necessary.
First, the overall configuration of the hemodialysis apparatus 1 of this embodiment will be described with reference to FIG. The hemodialyzer 1 as a dialyzer includes a dialyzer 10 as a hemodialyzer, a blood circuit 20, a dialysate circuit 30, a replenisher line 38, and a console 100. The console 100 is provided with an operation panel 70, a clamp unit 60, a part of the blood circuit 20, a part of the dialysate circuit 30, a heater 40 as a temperature control unit, a drug solution pump 231, a replacement fluid pump 39, and a control device 50. Has been done.
　ダイアライザ１０は、筒状に形成された容器本体１１と、この容器本体１１の内部に収容された透析膜（図示せず）と、を備え、容器本体１１の内部は、透析膜により血液側流路と透析液側流路とに区画される（いずれも図示せず）。容器本体１１には、血液側流路に連通する血液導入口１１１及び血液導出口１１２と、透析液側流路に連通する透析液導入口１１３及び透析液導出口１１４と、が形成される。 The dialyzer 10 includes a container body 11 formed in a tubular shape and a dialysis membrane (not shown) housed inside the container body 11. And a dialysate-side flow path (both not shown). The container body 11 is formed with a blood inlet 111 and a blood outlet 112 that communicate with the blood-side channel, and a dialysate inlet 113 and a dialysate outlet 114 that communicate with the dialysate-side channel.
　血液回路２０は、動脈側ライン２１と、静脈側ライン２２と、薬剤ライン２３と、オーバーフローライン２４と、を備える。動脈側ライン２１、静脈側ライン２２、薬剤ライン２３及びオーバーフローライン２４は、いずれも液体が流通可能な可撓性を有するチューブを主体として構成される。 The blood circuit 20 includes an artery side line 21, a vein side line 22, a drug line 23, and an overflow line 24. The arterial side line 21, the vein side line 22, the drug line 23, and the overflow line 24 are each mainly configured by a flexible tube through which a liquid can flow.
　本実施形態においては、動脈側ライン２１、静脈側ライン２２、薬剤ライン２３及びオーバーフローライン２４を構成するチューブは、例えば、ポリ塩化ビニル（ＰＶＣ）、シリコン（Ｓｉ）等の可撓性のチューブで形成される。チューブとしては、例えば、外径が５．５ｍｍ、内径が３．３ｍｍのものなどが用いられる。チューブの硬度は、例えば、５０～８５程度（ＪＩＳ　Ｋ７２１５）のものなどが用いられる。 In the present embodiment, the tubes forming the artery side line 21, the vein side line 22, the drug line 23, and the overflow line 24 are flexible tubes such as polyvinyl chloride (PVC) and silicon (Si). It is formed. As the tube, for example, a tube having an outer diameter of 5.5 mm and an inner diameter of 3.3 mm is used. The tube has a hardness of, for example, about 50 to 85 (JIS K7215).
　動脈側ライン２１は、一端側が対象者（透析患者）の動脈に接続され、他端側がダイアライザ１０の血液導入口１１１に接続される。動脈側ライン２１の途中には、コンソール１００が配置される。コンソール１００において、動脈側ライン２１が通る部分には、クランプユニット６０及び血液ポンプ２１２が配置される。クランプユニット６０における動脈側ライン２１が通る部分には、動脈側クランプ部（クランプ部）６５、荷重検出部６６、及び動脈側気泡センサ（気泡検知部）６７が配置される。クランプユニット６０の詳細については後述する。 The arterial line 21 has one end connected to the artery of the subject (dialysis patient) and the other end connected to the blood inlet 111 of the dialyzer 10. The console 100 is arranged in the middle of the artery side line 21. In the console 100, the clamp unit 60 and the blood pump 212 are arranged in a portion where the artery side line 21 passes. An arterial side clamp section (clamp section) 65, a load detection section 66, and an arterial side bubble sensor (bubble detection section) 67 are arranged in a portion of the clamp unit 60 through which the artery side line 21 passes. Details of the clamp unit 60 will be described later.
　血液ポンプ２１２は、動脈側ライン２１におけるクランプユニット６０よりも下流側に配置される。血液ポンプ２１２は、動脈側ライン２１を構成するチューブをローラでしごくことにより、動脈側ライン２１の内部の血液やプライミング液等の液体を送り出す。 Blood pump 212 is arranged downstream of clamp unit 60 in arterial line 21. The blood pump 212 squeezes the tube that constitutes the artery-side line 21 with a roller, and thereby delivers the liquid such as blood and priming fluid inside the artery-side line 21.
　静脈側ライン２２は、一端側がダイアライザ１０の血液導出口１１２に接続され、他端側が対象者（透析患者）の静脈に接続される。静脈側ライン２２の途中には、静脈側チャンバ２２２及びコンソール１００が配置される。コンソール１００において、静脈側ライン２２が通る部分には、クランプユニット６０が配置される。クランプユニット６０における静脈側ライン２２が通る部分には、静脈側クランプ部６９及び静脈側気泡センサ６８が配置される。クランプユニット６０の詳細については後述する。 The vein side line 22 has one end connected to the blood outlet 112 of the dialyzer 10 and the other end connected to the vein of the subject (dialysis patient). In the middle of the vein side line 22, the vein side chamber 222 and the console 100 are arranged. In the console 100, the clamp unit 60 is arranged at a portion where the vein side line 22 passes. A vein side clamp portion 69 and a vein side bubble sensor 68 are arranged in a portion of the clamp unit 60 through which the vein side line 22 passes. Details of the clamp unit 60 will be described later.
　静脈側チャンバ２２２は、静脈側ライン２２におけるダイアライザ１０とコンソール１００との間に配置される。静脈側チャンバ２２２は、所定量（例えば、２０ｍｌ）の血液を貯留する。 The vein side chamber 222 is arranged between the dialyzer 10 and the console 100 in the vein side line 22. The vein side chamber 222 stores a predetermined amount (for example, 20 ml) of blood.
　薬剤ライン２３は、血液透析中に必要な薬剤を動脈側ライン２１に供給する。薬剤ライン２３は、一端側（基端側）が薬剤を送り出す薬液ポンプ２３１に接続され、他端側（先端側）が動脈側ライン２１における血液ポンプ２１２とダイアライザ１０との間に接続される。 The drug line 23 supplies the drug required during hemodialysis to the arterial line 21. One end side (proximal end side) of the drug line 23 is connected to a drug solution pump 231 that delivers a drug, and the other end side (tip end side) is connected between the blood pump 212 and the dialyzer 10 in the arterial side line 21.
　オーバーフローライン２４は、一端側（基端側）が静脈側チャンバ２２２に接続される。オーバーフローライン２４は、プライミング工程において静脈側ライン２２を流通する生理食塩液、空気等を外部に排出する。オーバーフローライン２４には、オーバーフロークランプ２４１が配置される。オーバーフロークランプ２４１は、オーバーフローライン２４の流路を開閉する。 The overflow line 24 has one end side (base end side) connected to the vein side chamber 222. The overflow line 24 discharges the physiological saline solution, air and the like flowing through the vein side line 22 to the outside in the priming process. An overflow clamp 241 is arranged in the overflow line 24. The overflow clamp 241 opens and closes the flow path of the overflow line 24.
　以上の血液回路２０によれば、対象者（透析患者）の動脈から取り出された血液は、血液ポンプ２１２により動脈側ライン２１を流通してダイアライザ１０の血液側流路に導入される。ダイアライザ１０に導入された血液は、透析膜を介して後述する透析液回路３０を流通する透析液により浄化される。ダイアライザ１０において浄化された血液は、静脈側ライン２２を流通して対象者の静脈に返血される。 According to the blood circuit 20 described above, the blood extracted from the artery of the subject (dialysis patient) flows through the artery side line 21 by the blood pump 212 and is introduced into the blood side flow path of the dialyzer 10. The blood introduced into the dialyzer 10 is purified by the dialysate flowing through the dialysate circuit 30 described later through the dialyzing membrane. The blood purified by the dialyzer 10 flows through the vein side line 22 and is returned to the vein of the subject.
　透析液回路３０は、本実施形態では、いわゆる密閉容量制御方式の透析液回路３０により構成される。この透析液回路３０は、透析液チャンバ３１と、透析液供給ライン３２と、透析液導入ライン３３と、透析液導出ライン３４と、排液ライン３５と、バイパスライン３６と、除水／逆ろ過ポンプ３７と、を備える。 In the present embodiment, the dialysate circuit 30 is composed of a so-called closed capacity control type dialysate circuit 30. The dialysate circuit 30 includes a dialysate chamber 31, a dialysate supply line 32, a dialysate introduction line 33, a dialysate outlet line 34, a drain line 35, a bypass line 36, and water removal / reverse filtration. And a pump 37.
　透析液チャンバ３１は、一定容量（例えば、３００ｍｌ～５００ｍｌ）の透析液を収容可能な硬質の容器３１１と、この容器３１１の内部を区画する軟質の隔膜（ダイアフラム）３１２と、を備える。透析液チャンバ３１の内部は、隔膜３１２により送液収容部３１３及び排液収容部３１４に区画される。 The dialysate chamber 31 includes a hard container 311 that can store a fixed volume (for example, 300 ml to 500 ml) of dialysate, and a soft diaphragm (diaphragm) 312 that partitions the interior of the container 311. The interior of the dialysate chamber 31 is partitioned by a diaphragm 312 into a liquid feed storage 313 and a drainage storage 314.
　透析液供給ライン３２は、基端側が透析液供給装置（図示せず）に接続され、先端側が透析液チャンバ３１に接続される。透析液供給ライン３２は、透析液チャンバ３１の送液収容部３１３に透析液を供給する。 The dialysate supply line 32 has a proximal end connected to a dialysate supply device (not shown) and a distal end connected to the dialysate chamber 31. The dialysate supply line 32 supplies the dialysate to the liquid delivery container 313 of the dialysate chamber 31.
　透析液導入ライン３３は、透析液チャンバ３１とダイアライザ１０の透析液導入口１１３とを接続し、透析液チャンバ３１の送液収容部３１３に収容された透析液をダイアライザ１０の透析液側流路に導入する。 The dialysate introduction line 33 connects the dialysate chamber 31 and the dialysate inlet 113 of the dialyzer 10, and connects the dialysate contained in the solution delivery container 313 of the dialysate chamber 31 to the dialysate-side flow path of the dialyzer 10. To introduce.
　透析液導出ライン３４は、ダイアライザ１０の透析液導出口１１４と透析液チャンバ３１とを接続し、ダイアライザ１０から排出された透析液を透析液チャンバ３１の排液収容部３１４に導出する。
　排液ライン３５は、基端側が透析液チャンバ３１に接続され、排液収容部３１４に収容された透析液の排液を排出する。 The dialysate outlet line 34 connects the dialysate outlet 114 of the dialyzer 10 and the dialysate chamber 31, and leads the dialysate discharged from the dialyzer 10 to the drainage storage portion 314 of the dialysate chamber 31.
The drain line 35 is connected to the dialysate chamber 31 on the proximal end side and drains the drainage of the dialysate stored in the drainage container 314.
　バイパスライン３６は、透析液導出ライン３４と排液ライン３５とを接続する。
　除水／逆ろ過ポンプ３７は、バイパスライン３６に配置される。除水／逆ろ過ポンプ３７は、バイパスライン３６の内部の透析液を排液ライン３５側に流通させる方向（除水方向）及び透析液導出ライン３４側に流通させる方向（逆ろ過方向）に送液可能に駆動するポンプにより構成される。 The bypass line 36 connects the dialysate outlet line 34 and the drain line 35.
The dewatering / back filtration pump 37 is arranged in the bypass line 36. The water removal / reverse filtration pump 37 sends the dialysate inside the bypass line 36 to the drainage line 35 side (removal direction) and to the dialysate discharge line 34 side (reverse filtration direction). It is composed of a pump that drives liquid.
　ヒータ４０は、透析液回路３０を流通する透析液を所定の温度に加温する。 The heater 40 heats the dialysate flowing through the dialysate circuit 30 to a predetermined temperature.
　補充液ライン３８は、透析液を血液回路２０に直接供給するためのラインである。図１に示すように、補充液ライン３８の上流側は、透析液回路３０の透析液導入ライン３３における透析液チャンバ３１とダイアライザ１０の透析液導入口１１３との間に接続されている。補充液ライン３８には、補充液用クランプ３８１が設けられている。図１の実線で示すように、補充液ライン３８の下流側が、動脈側ライン２１における血液ポンプ２１２とダイアライザ１０との間に接続される場合は、前希釈方式の血液濾過透析となる。また、図１の破線で示すように、補充液ライン３８の下流側が、静脈側ライン２２における静脈側チャンバ２２２に接続される場合は、後希釈方式の血液濾過透析となる。 The replenisher line 38 is a line for directly supplying the dialysate to the blood circuit 20. As shown in FIG. 1, the upstream side of the replenisher line 38 is connected between the dialysate chamber 31 in the dialysate introduction line 33 of the dialysate circuit 30 and the dialysate inlet 113 of the dialyzer 10. The replenisher line 38 is provided with a replenisher clamp 381. As shown by the solid line in FIG. 1, when the downstream side of the replenisher line 38 is connected between the blood pump 212 and the dialyzer 10 in the arterial line 21, predilution type hemofiltration / dialysis is performed. Further, as shown by the broken line in FIG. 1, when the downstream side of the replenisher solution line 38 is connected to the vein side chamber 222 in the vein side line 22, the post-dilution type hemofiltration dialysis is performed.
　クランプユニット６０について説明する。
　クランプユニット６０は、図１に示すように、ユニット化されて構成されており、コンソール１００に取り付けられる。クランプユニット６０は、動脈側ライン２１を構成するチューブ、及び静脈側ライン２２を構成するチューブをクランプして保持する。クランプユニット６０には、幅方向Ｈの一方側において、動脈側ライン２１を構成するチューブが上下方向に亘って配置され、幅方向Ｈの他方側において、静脈側ライン２２を構成するチューブが上下方向に亘って配置される。 The clamp unit 60 will be described.
As shown in FIG. 1, the clamp unit 60 is configured as a unit and is attached to the console 100. The clamp unit 60 clamps and holds the tube forming the artery side line 21 and the tube forming the vein side line 22. In the clamp unit 60, on one side in the width direction H, the tubes forming the artery side line 21 are arranged in the vertical direction, and on the other side in the width direction H, the tubes forming the vein side line 22 are arranged in the vertical direction. It is arranged over.
　クランプユニット６０は、図２～図５に示すように、ユニット本体６１と、ユニット本体６１を開閉する蓋部６２と、ヒンジ部６３と、開閉レバー６４１と、開閉係合部６４２と、基板６６４（図５参照）と、荷重検出部６６と、を備える。クランプユニット６０は、ユニット本体６１と蓋部６２との間にチューブを配置することでチューブを固定する。クランプユニット６０は、ユニット本体６１の内面に動脈側ライン２１を構成するチューブ及び静脈側ライン２２を構成するチューブを配置した状態で、ユニット本体６１の内面側に蓋部６２の内面を押し付けることで、動脈側ライン２１を構成するチューブ及び静脈側ライン２２を構成するチューブを固定する。 As shown in FIGS. 2 to 5, the clamp unit 60 includes a unit body 61, a lid portion 62 that opens and closes the unit body 61, a hinge portion 63, an opening / closing lever 641, an opening / closing engagement portion 642, and a substrate 664. (See FIG. 5) and a load detection unit 66. The clamp unit 60 fixes the tube by disposing the tube between the unit body 61 and the lid portion 62. The clamp unit 60 is configured such that the inner surface of the unit main body 61 has the tubes forming the artery side line 21 and the tube forming the vein side line 22 arranged therein, and the inner surface of the unit main body 61 is pressed against the inner surface of the lid portion 62. The tube forming the artery side line 21 and the tube forming the vein side line 22 are fixed.
　蓋部６２の内面は、動脈側ライン２１を構成するチューブ及び静脈側ライン２２を構成するチューブを一定の力で固定するチューブ固定部を構成する。蓋部６２の内面を構成する部材において、少なくともチューブを押圧する部分の材料としては、例えば、樹脂材料が用いられ、ＡＢＳ樹脂（アクリロニトリル・ブタジエン・スチレン共重合体）、ＡＳＡ樹脂（ＡＢＳ樹脂のブタジエンに代替し、アクリルゴムを重合させたもの）、ポリプロピレン等の合成樹脂などが用いられる。これにより、蓋部６２の内面は、動脈側ライン２１を構成するチューブ及び静脈側ライン２２を構成するチューブを、十分に保持すると共につぶし過ぎないような適切な保持力で固定できる。 The inner surface of the lid portion 62 forms a tube fixing portion that fixes the tube forming the artery side line 21 and the tube forming the vein side line 22 with a constant force. In the member forming the inner surface of the lid portion 62, for example, a resin material is used as the material of at least the portion that presses the tube, and ABS resin (acrylonitrile-butadiene-styrene copolymer), ASA resin (butadiene resin of ABS resin) is used. In place of acrylic rubber), synthetic resins such as polypropylene, etc. are used. Accordingly, the inner surface of the lid portion 62 can be fixed with an appropriate holding force that sufficiently holds the tube forming the artery side line 21 and the tube forming the vein side line 22 and does not crush it too much.
　ヒンジ部６３は、図２に示すように、蓋部６２の閉鎖時に、クランプユニット６０の幅方向Ｈの他方側の端部に配置され、蓋部６２をユニット本体６１に対して回動可能に接続する。 As shown in FIG. 2, the hinge portion 63 is arranged at the other end of the clamp unit 60 in the width direction H when the lid portion 62 is closed so that the lid portion 62 can rotate with respect to the unit body 61. Connecting.
　開閉レバー６４１は、蓋部６２の閉鎖時に、蓋部６２の幅方向Ｈの一方側の端部に設けられる。開閉係合部６４２は、図３に示すように、蓋部６２の閉鎖時に、開閉レバー６４１に係合可能に、ユニット本体６１の内面の幅方向Ｈの一方側の端部に設けられる。開閉レバー６４１を操作することで、ユニット本体６１と蓋部６２との開閉が行われる。 The opening / closing lever 641 is provided at one end of the lid portion 62 on one side in the width direction H when the lid portion 62 is closed. As shown in FIG. 3, the opening / closing engagement portion 642 is provided at an end portion on one side in the width direction H of the inner surface of the unit body 61 so that the opening / closing lever 641 can be engaged when the lid portion 62 is closed. By operating the opening / closing lever 641, the unit body 61 and the lid 62 are opened / closed.
　ユニット本体６１の内面には、図３に示すように、本体側動脈側チューブ配置部６１１（チューブ配置部）と、本体側静脈側チューブ配置部６１２（チューブ配置部）と、が形成されている。本体側動脈側チューブ配置部６１１及び本体側静脈側チューブ配置部６１２は、ユニット本体６１の内面において、ユニット本体６１の幅方向Ｈに離間して配置され、直線状に延びる。本体側静脈側チューブ配置部６１２は、本体側動脈側チューブ配置部６１１よりも幅方向Ｈにおけるヒンジ部６３側に配置される。 As shown in FIG. 3, a main body side arterial tube placement section 611 (tube placement section) and a main body side vein side tube placement section 612 (tube placement section) are formed on the inner surface of the unit main body 61. . The main body side arterial tube placement section 611 and the main body side vein side tube placement section 612 are arranged on the inner surface of the unit main body 61 so as to be spaced apart in the width direction H of the unit main body 61 and extend linearly. The main body side vein side tube placement portion 612 is placed closer to the hinge portion 63 side in the width direction H than the main body side arterial side tube placement portion 611.
　図５に示すように、ユニット本体６１の外面６１３（図８参照）には、基板６６４が取り付けられている。基板６６４のユニット本体６１側の第１面６６４ａ（図８参照）には、荷重検出部６６のフォースセンサ６６５（荷重検出センサ）が実装（配置）されている（後述、図８参照）。 As shown in FIG. 5, a board 664 is attached to the outer surface 613 (see FIG. 8) of the unit main body 61. A force sensor 665 (load detection sensor) of the load detection unit 66 is mounted (disposed) on the first surface 664a (see FIG. 8) of the board 664 on the unit body 61 side (see FIG. 8 described later).
　蓋部６２の内面には、図３に示すように、蓋部６２の閉鎖時に、本体側動脈側チューブ配置部６１１に対向して配置される蓋部側動脈側チューブ配置部６２１と、本体側静脈側チューブ配置部６１２に対向して配置される蓋部側静脈側チューブ配置部６２２と、が形成されている。蓋部側動脈側チューブ配置部６２１及び蓋部側静脈側チューブ配置部６２２は、蓋部６２の内面において、蓋部６２の幅方向Ｈに離間して配置され、直線状に延びる。蓋部側静脈側チューブ配置部６２２は、蓋部側動脈側チューブ配置部６２１よりも幅方向Ｈのヒンジ部６３側に配置される。 As shown in FIG. 3, on the inner surface of the lid portion 62, when the lid portion 62 is closed, the lid portion side arterial tube placement portion 621 that is placed to face the main body side arterial side tube placement portion 611, and the main body side A lid side vein side tube placement portion 622, which is placed so as to face the vein side tube placement portion 612, is formed. The lid side arterial tube placement section 621 and the lid side vein side tube placement section 622 are arranged on the inner surface of the lid section 62 so as to be separated from each other in the width direction H of the lid section 62 and extend linearly. The lid side vein side tube placement portion 622 is placed closer to the hinge portion 63 side in the width direction H than the lid side artery side tube placement portion 621.
　蓋部６２の閉鎖時において、本体側動脈側チューブ配置部６１１と蓋部側動脈側チューブ配置部６２１との間には、動脈側ライン２１を構成するチューブが配置され、本体側静脈側チューブ配置部６１２と蓋部側静脈側チューブ配置部６２２との間には、静脈側ライン２２を構成するチューブが配置される。 When the lid 62 is closed, the tube forming the artery side line 21 is arranged between the main body side arterial tube placement section 611 and the lid side arterial side tube placement section 621, and the main body side vein side tube placement is arranged. The tube forming the vein side line 22 is arranged between the portion 612 and the lid side vein side tube placement portion 622.
　ここで、まず、本体側動脈側チューブ配置部６１１及び蓋部側動脈側チューブ配置部６２１に設けられる構成について説明する。
　図３及び図６に示すように、蓋部６２の閉鎖時において、本体側動脈側チューブ配置部６１１及び蓋部側動脈側チューブ配置部６２１に沿って、動脈側上流チューブ押さえ部６０１、動脈側クランプ部６５、荷重検出部６６、動脈側気泡センサ６７及び動脈側下流チューブ押さえ部６０２が配置される。本実施形態においては、動脈側上流チューブ押さえ部６０１、動脈側クランプ部６５、荷重検出部６６、動脈側気泡センサ６７及び動脈側下流チューブ押さえ部６０２は、クランプユニット６０において、上流側から下流側（図１及び図３における下方側から上方側）に向かって、この順に並んで配置されている。 Here, first, the configuration provided in the main body side arterial tube placement section 611 and the lid side arterial side tube placement section 621 will be described.
As shown in FIG. 3 and FIG. 6, when the lid 62 is closed, the arterial upstream tube retainer 601 and the artery side along the main body side arterial tube placement part 611 and the lid side arterial side tube placement part 621. A clamp part 65, a load detection part 66, an artery side air bubble sensor 67 and an artery side downstream tube pressing part 602 are arranged. In the present embodiment, the artery-side upstream tube pressing portion 601, the artery-side clamping portion 65, the load detecting portion 66, the artery-side bubble sensor 67, and the artery-side downstream tube pressing portion 602 are arranged in the clamp unit 60 from the upstream side to the downstream side. They are arranged side by side in this order from the lower side to the upper side in FIGS. 1 and 3.
　本体側動脈側チューブ配置部６１１は、図３に示すように、ユニット本体６１の内面に配置される。本体側動脈側チューブ配置部６１１には、動脈側ライン２１を構成するチューブを流通する液体の上流側から下流側（図３の下方側から上方側）に向かって順に、動脈側上流チューブ押さえ部６０１の収容凹部６０１ａ、動脈側クランプ部６５の動脈側可動クランプ部６５１、荷重検出部６６の荷重受け部６６２、動脈側気泡センサ６７の超音波発振部６７１が内部に収容された動脈側気泡センサ受け部材６７２、動脈側下流チューブ押さえ部６０２の収容凹部６０２ａが並んで配置される。 The main body side artery side tube placement portion 611 is placed on the inner surface of the unit main body 61 as shown in FIG. In the main body side arterial tube placement section 611, the arterial side upstream tube holding section is arranged in order from the upstream side to the downstream side (from the lower side to the upper side in FIG. 3) of the liquid flowing through the tube forming the artery side line 21. An arterial-side bubble sensor in which an accommodating recess 601a of 601, an arterial-side movable clamp part 651 of the arterial-side clamp part 65, a load receiving part 662 of the load detecting part 66, and an ultrasonic wave oscillating part 671 of the arterial-side bubble sensor 67 are accommodated inside. The receiving member 672 and the accommodating recess 602a of the artery-side downstream tube pressing portion 602 are arranged side by side.
　蓋部側動脈側チューブ配置部６２１は、蓋部６２の内面に配置され、蓋部６２の閉鎖時に本体側動脈側チューブ配置部６１１に対向して配置される。蓋部側動脈側チューブ配置部６２１には、動脈側ライン２１を構成するチューブを流通する液体の上流側から下流側（図３の下方側から上方側）に向かって順に、動脈側上流チューブ押さえ部６０１の押さえ凸部６０１ｂ、動脈側クランプ部６５の動脈側クランプ受け部６５２、荷重検出部６６の荷重押さえ部６６３、動脈側気泡センサ６７の超音波受信部６７３が内部に収容された動脈側気泡センサ押さえ部材６７４、動脈側下流チューブ押さえ部６０２の押さえ凸部６０２ｂが並んで配置されている。 The lid-side artery-side tube placement portion 621 is placed on the inner surface of the lid portion 62, and is placed so as to face the main-body-side artery-side tube placement portion 611 when the lid portion 62 is closed. The lid-side artery-side tube placement portion 621 sequentially holds the arterial-side upstream tube retainer from the upstream side to the downstream side (from the lower side to the upper side in FIG. 3) of the liquid flowing through the tube forming the artery-side line 21. Arterial side in which the pressing convex portion 601b of the portion 601, the arterial side clamp receiving portion 652 of the arterial side clamping portion 65, the load holding portion 663 of the load detecting portion 66, and the ultrasonic wave receiving portion 673 of the arterial side air bubble sensor 67 are housed inside. The bubble sensor pressing member 674 and the pressing convex portion 602b of the artery-side downstream tube pressing portion 602 are arranged side by side.
　動脈側上流チューブ押さえ部６０１の押さえ凸部６０１ｂは、蓋部６２の閉鎖時に、ユニット本体６１に配置される収容凹部６０１ａに対向して配置され、クランプユニット６０における動脈側ライン２１を流通する液体の上流側（図３における下方側）において、動脈側ライン２１を構成するチューブを押さえる。 The pressing convex portion 601b of the artery-side upstream tube pressing portion 601 is arranged so as to face the accommodating concave portion 601a arranged in the unit main body 61 when the lid portion 62 is closed, and the liquid flowing through the artery-side line 21 in the clamp unit 60. At the upstream side (downward side in FIG. 3) of, the tube forming the artery side line 21 is pressed.
　動脈側クランプ受け部６５２は、蓋部６２の閉鎖時において、ユニット本体６１に配置される動脈側可動クランプ部６５１に対向して配置される。動脈側クランプ受け部６５２及び動脈側可動クランプ部６５１は、動脈側クランプ部６５を構成し、動脈側ライン２１を構成するチューブを挟んで保持する。 The artery-side clamp receiving portion 652 is arranged so as to face the artery-side movable clamp portion 651 arranged in the unit main body 61 when the lid portion 62 is closed. The artery-side clamp receiving portion 652 and the artery-side movable clamp portion 651 constitute the artery-side clamp portion 65, and hold the tube constituting the artery-side line 21 by sandwiching it.
　動脈側クランプ部６５は、図３及び図６に示すように、ユニット本体６１に配置される動脈側可動クランプ部６５１と、ユニット本体６１に配置され動脈側可動クランプ部６５１を駆動するソレノイド６５３と、蓋部６２に配置される動脈側クランプ受け部６５２と、を有する。動脈側クランプ受け部６５２は、蓋部６２の内面から突出して形成され、幅方向Ｈに延びる。 As shown in FIGS. 3 and 6, the artery-side clamp portion 65 includes an artery-side movable clamp portion 651 arranged in the unit body 61, and a solenoid 653 arranged in the unit body 61 and driving the artery-side movable clamp portion 651. , And an artery-side clamp receiving portion 652 arranged on the lid portion 62. The artery-side clamp receiving portion 652 is formed so as to project from the inner surface of the lid portion 62 and extends in the width direction H.
　動脈側可動クランプ部６５１は、図６に示すように、先端が幅方向Ｈに延びる平面状に形成されると共にチューブ配置部が延びる方向に切断した断面において先端側の幅が狭い台形状に形成される。動脈側可動クランプ部６５１の後端には、ソレノイド６５３の出力軸６５３ａが、進退可能に接続されている。動脈側可動クランプ部６５１は、ソレノイド６５３の出力軸６５３ａの進退により、動脈側ライン２１を構成するチューブを、動脈側可動クランプ部６５１の先端及び動脈側クランプ受け部６５２の先端で挟み込んでクランプし、又は、動脈側ライン２１を開閉する。 As shown in FIG. 6, the arterial-side movable clamp portion 651 has a distal end formed in a flat shape extending in the width direction H, and a trapezoid shape in which the width on the distal end side is narrow in a cross section cut in the extending direction of the tube placement portion. To be done. An output shaft 653a of a solenoid 653 is connected to the rear end of the artery-side movable clamp portion 651 so as to be able to move forward and backward. The arterial-side movable clamp section 651 clamps the tube forming the arterial-side line 21 by sandwiching the tube forming the arterial-side line 21 between the tip of the arterial-side clamp section 651 and the tip of the arterial-side clamp receiving section 652 by advancing and retracting the output shaft 653a of the solenoid 653. Alternatively, the artery side line 21 is opened and closed.
　以上のように構成される動脈側クランプ部６５は、血液透析装置１の通常動作時に、動脈側可動クランプ部６５１及び動脈側クランプ受け部６５２により、ユニット本体６１と蓋部６２との間に配置される動脈側ライン２１を構成するチューブをクランプする。
　また、動脈側クランプ部６５は、生理食塩水を用いたプライミング及び返血工程で開閉される。動脈側クランプ部６５は、動脈側可動クランプ部６５１を進退させて、動脈側ライン２１を構成するチューブを押し潰したり開放し、動脈側ライン２１の流路を開閉することで、動脈側気泡センサ６７よりも上流側において、チューブの内部を流通する液体の送液を流通／停止させる。 The arterial side clamp part 65 configured as described above is arranged between the unit main body 61 and the lid part 62 by the arterial side movable clamp part 651 and the arterial side clamp receiving part 652 during the normal operation of the hemodialysis apparatus 1. The tube forming the arterial line 21 to be clamped is clamped.
Further, the arterial side clamp portion 65 is opened and closed in the priming and blood returning process using physiological saline. The arterial side clamp part 65 moves the arterial side movable clamp part 651 forwards and backwards to crush and open the tube forming the arterial side line 21 and open and close the flow path of the arterial side line 21. On the upstream side of 67, the flow of the liquid flowing through the inside of the tube is made to flow / stop.
　荷重検出部６６は、動脈側ライン２１を構成するチューブからの圧力による荷重を検出し、電圧値として出力可能である。つまり、チューブが閉塞するとチューブ内の圧力が陽圧または陰圧となり、チューブの径方向が変化し、それと共に荷重が変化し、結果として電圧値の変化として検出される。荷重検出部６６は、図７に示すように、荷重押さえ部６６３と、荷重受け部６６２と、基板６６４に配置されたフォースセンサ６６５と、荷重吸収部８０と、を有する。荷重検出部６６は閉塞検知装置を構成する。 The load detection unit 66 can detect the load due to the pressure from the tube forming the artery side line 21 and output it as a voltage value. That is, when the tube is closed, the pressure in the tube becomes positive pressure or negative pressure, the radial direction of the tube changes, and the load changes with it, and as a result, it is detected as a change in voltage value. As shown in FIG. 7, the load detector 66 includes a load retainer 663, a load receiver 662, a force sensor 665 arranged on the substrate 664, and a load absorber 80. The load detection unit 66 constitutes a blockage detection device.
　荷重押さえ部６６３は、図３、図６及び図７に示すように、蓋部６２の閉鎖時に、ユニット本体６１に配置される荷重受け部６６２に対向して配置され、動脈側ライン２１を構成するチューブを押さえる。なお、荷重押さえ部６６３は、チューブの径を変更した場合に、荷重検出部６６から出力される電圧値が同程度の電圧値を得られるように、高さ調整を可能な構成としてもよいし、高さが異なる荷重押さえ部に交換可能な構成としてもよい。 As shown in FIGS. 3, 6, and 7, the load holding portion 663 is arranged to face the load receiving portion 662 arranged in the unit main body 61 when the lid portion 62 is closed, and constitutes the artery side line 21. Hold down the tube. It should be noted that the load holding unit 663 may have a height-adjustable configuration so that when the diameter of the tube is changed, the voltage values output from the load detecting unit 66 can be similar voltage values. Alternatively, the load holding portions having different heights may be exchangeable.
　荷重受け部６６２は、蓋部６２の閉鎖時に、荷重押さえ部６６３に押さえられた動脈側ライン２１を構成するチューブからの圧力により荷重を受ける。荷重受け部６６２は、基板６６４に配置されたフォースセンサ６６５へ荷重を伝達する。荷重受け部６６２は、図８に示すように、表面シート部６６２ａと、押圧部６６２ｂと、伝達軸部６６２ｃと、を有する。表面シート部６６２ａは、チューブ側に配置され、蓋部６２の閉鎖時に、動脈側ライン２１を構成するチューブに当接される。押圧部６６２ｂ及び伝達軸部６６２ｃは、ユニット本体６１の連通穴６１５に配置される。連通穴６１５は、ユニット本体６１の内面と外面６１３とを連通して形成されている。表面シート部６６２ａ、押圧部６６２ｂ及び伝達軸部６６２ｃは、ユニット本体６１の内面側から外面６１３側に向けてこの順で配置される。 The load receiving portion 662 receives the load due to the pressure from the tube forming the artery side line 21 which is held by the load holding portion 663 when the lid 62 is closed. The load receiving portion 662 transmits the load to the force sensor 665 arranged on the substrate 664. As shown in FIG. 8, the load receiving portion 662 has a surface sheet portion 662a, a pressing portion 662b, and a transmission shaft portion 662c. The surface sheet portion 662a is arranged on the tube side and is brought into contact with the tube forming the artery side line 21 when the lid portion 62 is closed. The pressing portion 662b and the transmission shaft portion 662c are arranged in the communication hole 615 of the unit body 61. The communication hole 615 communicates with the inner surface of the unit body 61 and the outer surface 613. The surface sheet portion 662a, the pressing portion 662b, and the transmission shaft portion 662c are arranged in this order from the inner surface side of the unit body 61 toward the outer surface 613 side.
　フォースセンサ６６５は、図８に示すように、基板６６４におけるユニット本体６１側に形成される第１面６６４ａに実装（配置）されている。基板６６４は、ユニット本体６１の外面６１３に取り付けられる。基板６６４は、連通穴６１５を塞ぐように、連通穴６１５が延びる方向に交差するように配置されている。基板６６４は、ユニット本体６１側の第１面６６４ａが、ユニット本体６１の外面６１３に当接され、第１面６６４ａと反対側の第２面６６４ｂが、後述する２つのバネ部材８２，８２によりユニット本体６１側に向けて押圧されている。 As shown in FIG. 8, the force sensor 665 is mounted (disposed) on the first surface 664 a formed on the unit body 61 side of the board 664. The substrate 664 is attached to the outer surface 613 of the unit body 61. The board 664 is arranged so as to close the communication hole 615 and intersect with the direction in which the communication hole 615 extends. In the board 664, the first surface 664a on the unit body 61 side is brought into contact with the outer surface 613 of the unit body 61, and the second surface 664b on the side opposite to the first surface 664a is formed by two spring members 82 and 82 described later. It is pressed toward the unit body 61 side.
　フォースセンサ６６５は、ユニット本体６１の外面６１３側において連通穴６１５の延長線上に配置されている。連通穴６１５には、前述の通り、荷重受け部６６２が配置されている。 The force sensor 665 is arranged on the extension line of the communication hole 615 on the outer surface 613 side of the unit main body 61. The load receiving portion 662 is arranged in the communication hole 615 as described above.
　蓋部６２によりユニット本体６１を閉じた場合に、蓋部６２の荷重押さえ部６６３とフォースセンサ６６５との間には、荷重押さえ部６６３側からフォースセンサ６６５側に向けて、動脈側ライン２１を構成するチューブ及び荷重受け部６６２がこの順に配置される。 When the unit main body 61 is closed by the lid portion 62, the artery side line 21 is provided between the load holding portion 663 and the force sensor 665 of the lid portion 62 from the load holding portion 663 side toward the force sensor 665 side. The constituent tubes and the load receiving portion 662 are arranged in this order.
　以上のように構成されるフォースセンサ６６５は、荷重受け部６６２に作用するチューブからの圧力により、チューブの径方向に荷重受け部６６２が移動することで、荷重受け部６６２を介して、チューブからの圧力による荷重を検出する。これにより、フォースセンサ６６５は、動脈側ライン２１を構成するチューブの圧力による荷重を電圧として出力する。 The force sensor 665 configured as described above moves from the tube via the load receiving portion 662 as the load receiving portion 662 moves in the radial direction of the tube due to the pressure applied from the tube to the load receiving portion 662. The load due to the pressure of is detected. Accordingly, the force sensor 665 outputs the load due to the pressure of the tube forming the artery side line 21 as a voltage.
　荷重吸収部８０は、図８に示すように、基板６６４に配置される。荷重吸収部８０は、蓋部６２によりユニット本体６１を閉じて蓋部６２とフォースセンサ６６５との間にチューブが配置された状態において、フォースセンサ６６５に許容荷重以上（所定値以上）の荷重が掛かった場合に、フォースセンサ６６５を介して基板６６４に掛かった荷重を吸収する。荷重吸収部８０は、２つのガイドポスト８１，８１（ガイド部材）と、２つのバネ部材８２，８２（付勢部材）と、バネ部材８２，８２を接続する接続部材８３と、を有する。 The load absorbing unit 80 is arranged on the substrate 664 as shown in FIG. In the state where the lid body 62 closes the unit main body 61 and the tube is arranged between the lid portion 62 and the force sensor 665, the load absorbing portion 80 applies a load equal to or more than the allowable load (more than a predetermined value) to the force sensor 665. When applied, it absorbs the load applied to the substrate 664 via the force sensor 665. The load absorbing portion 80 includes two guide posts 81 and 81 (guide members), two spring members 82 and 82 (biasing members), and a connecting member 83 that connects the spring members 82 and 82.
　ガイドポスト８１及びバネ部材８２は、ガイドポスト８１及びバネ部材８２を１組として構成され、本実施形態においては、２組のガイドポスト８１及びバネ部材８２が備えられている。２組のガイドポスト８１及びバネ部材８２は、基板６６４の面方向において、フォースセンサ６６５が配置された部分を挟んだ２箇所に離間して配置される。 The guide post 81 and the spring member 82 are configured with the guide post 81 and the spring member 82 as one set, and in the present embodiment, two sets of the guide post 81 and the spring member 82 are provided. The two sets of the guide post 81 and the spring member 82 are arranged apart from each other in the plane direction of the substrate 664 at two positions sandwiching the portion where the force sensor 665 is arranged.
　２つのガイドポスト８１，８１は、それぞれ、円柱の棒状に形成され、基板６６４の厚さ方向に延びる。ガイドポスト８１は、基板６６４を厚さ方向に貫通して配置され、基板６６４を厚さ方向に移動可能に支持する。２つのガイドポスト８１，８１は、クランプユニット６０の幅方向Ｈに離間して配置される。２つのガイドポスト８１，８１は、それぞれ、一端側が、ユニット本体６１の外面６１３に形成された取付穴６１６に挿入されて固定され、他端側が、ユニット本体６１の外面６１３から突出する。２つの取付穴６１６は、連通穴６１５と平行に延びて形成され、基板６６４の面方向において、連通穴６１５を挟んでクランプユニット６０の幅方向Ｈに離間して配置される。 Each of the two guide posts 81, 81 is formed in a cylindrical rod shape and extends in the thickness direction of the substrate 664. The guide post 81 is arranged to penetrate the substrate 664 in the thickness direction and supports the substrate 664 so as to be movable in the thickness direction. The two guide posts 81, 81 are arranged apart from each other in the width direction H of the clamp unit 60. One end side of each of the two guide posts 81, 81 is inserted and fixed in a mounting hole 616 formed in the outer surface 613 of the unit body 61, and the other end side thereof projects from the outer surface 613 of the unit body 61. The two mounting holes 616 are formed to extend in parallel with the communication hole 615, and are arranged in the width direction H of the clamp unit 60 so as to sandwich the communication hole 615 in the surface direction of the substrate 664.
　接続部材８３は、クランプユニット６０の幅方向Ｈに延びる板状に形成される。接続部材８３は、２つのガイドポスト８１，８１の他端側の端部同士を接続する。接続部材８３の両端部は、それぞれ、ネジ８１１により、ガイドポスト８１の他端部に固定されている。 The connecting member 83 is formed in a plate shape extending in the width direction H of the clamp unit 60. The connecting member 83 connects the ends of the two guide posts 81, 81 on the other end side. Both ends of the connecting member 83 are fixed to the other end of the guide post 81 by screws 811.
　２つのバネ部材８２，８２は、図８に示すように、それぞれ、ガイドポスト８１に外装されるコイル状に形成される。バネ部材８２は、基板６６４の第２面６６４ｂと接続部材８３との間において伸縮可能に配置される。バネ部材８２は、フォースセンサ６６５に許容荷重以上の荷重が掛かった場合に、フォースセンサ６６５に掛かった荷重を吸収する側への基板６６４の移動を許容しつつ、フォースセンサ６６５に許容荷重未満の荷重が掛かった場合に、フォースセンサ６６５が検出位置に位置するように基板６６４を付勢する。 As shown in FIG. 8, the two spring members 82, 82 are each formed in a coil shape to be mounted on the guide post 81. The spring member 82 is arranged so as to be capable of expanding and contracting between the second surface 664b of the substrate 664 and the connecting member 83. The spring member 82 allows the force sensor 665 to move to a side that absorbs the load applied to the force sensor 665 when the load applied to the force sensor 665 is greater than the allowable load, and the force sensor 665 has a load less than the allowable load. When a load is applied, the substrate 664 is urged so that the force sensor 665 is located at the detection position.
　これにより、フォースセンサ６６５に許容荷重以上の荷重が掛かった場合にフォースセンサ６６５に掛かった荷重を吸収する側への基板６６４の移動を許容することで、フォースセンサ６６５に許容荷重以上（所定値以上）の荷重が掛かることを抑制できる。本実施形態においては、バネ部材８２のバネ定数は、フォースセンサ６６５に許可荷重未満の荷重が掛かった場合には縮小せずに、フォースセンサ６６５に許容荷重以上の荷重が掛かった場合のみに縮小される値が設定される。 As a result, when the force sensor 665 is applied with a load equal to or larger than the allowable load, the force sensor 665 is allowed to move toward the side that absorbs the load applied to the force sensor 665. It is possible to suppress the above load. In the present embodiment, the spring constant of the spring member 82 is not reduced when the force sensor 665 is applied with a load less than the allowable load, and is reduced only when the force sensor 665 is applied with a load equal to or greater than the allowable load. Value is set.
　以上のように構成される荷重吸収部８０においては、クランプユニット６０にチューブを配置する場合、チューブをユニット本体６１と蓋部６２との間に配置する際に、フォースセンサ６６５に許容荷重以上の荷重が掛かった場合に、バネ部材８２より基板６６４の厚さ方向への荷重を吸収できる。そのため、フォースセンサ６６５に許容荷重以上（所定値以上）の荷重が掛かることを抑制できる。よって、フォースセンサ６６５の破損を防げる。 In the load absorbing portion 80 configured as described above, when the tube is arranged in the clamp unit 60, when the tube is arranged between the unit main body 61 and the lid portion 62, the force sensor 665 has a load larger than the allowable load. When a load is applied, the spring member 82 can absorb the load in the thickness direction of the substrate 664. Therefore, it is possible to prevent the force sensor 665 from being applied with a load equal to or more than the allowable load (equal to or more than a predetermined value). Therefore, damage to the force sensor 665 can be prevented.
　また、クランプユニット６０の通常の使用状態において、フォースセンサ６６５に掛かる荷重は許容荷重未満の荷重であるため、荷重吸収部８０のバネ部材８２は縮小しない。つまり、通常の使用状態においては、荷重吸収部８０のバネ部材８２は縮小せずに、フォースセンサ６６５が検出位置に位置するように保持されるため、フォースセンサ６６５は、チューブからの圧力による荷重を正常に検出できる。これにより、荷重吸収部８０は、通常の使用状態において、フォースセンサ６６５によるチューブからの圧力による荷重の検出には影響を与えない。 In addition, since the load applied to the force sensor 665 is less than the allowable load when the clamp unit 60 is normally used, the spring member 82 of the load absorbing section 80 does not shrink. That is, in a normal use state, the spring member 82 of the load absorbing portion 80 is held so that the force sensor 665 is located at the detection position without being contracted. Therefore, the force sensor 665 applies the load due to the pressure from the tube. Can be normally detected. Accordingly, the load absorbing unit 80 does not affect the detection of the load due to the pressure from the tube by the force sensor 665 in the normal use state.
　よって、クランプユニット６０の通常の使用状態において、蓋部６２の閉鎖時に、蓋部６２が動脈側ライン２１を構成するチューブをフォースセンサ６６５側に押さえ付けることで、フォースセンサ６６５がチューブからの圧力による荷重を検出して、荷重を電圧値として出力する。荷重検出部６６により検出された検出値は、制御装置５０に送信されて、チューブが閉塞しているか否かが判定される。チューブが閉塞する場合としては、例えば、血液回路の接続後において鉗子を外し忘れた場合や、治療中の返血時の血栓による針先の詰まりや、脱血／透析時の針先の血管壁への張り付きや、脱血／透析／返血時の血管状態による血流量不足などを挙げることができる。 Therefore, in the normal use state of the clamp unit 60, when the lid portion 62 is closed, the lid portion 62 presses the tube forming the artery side line 21 toward the force sensor 665 side, so that the force sensor 665 presses the pressure from the tube. The load is detected and the load is output as a voltage value. The detection value detected by the load detection unit 66 is transmitted to the control device 50, and it is determined whether or not the tube is closed. Examples of the case where the tube is blocked include, for example, forgetting to remove the forceps after connecting the blood circuit, clogging of the needle tip due to a thrombus when returning blood during treatment, and blood vessel wall of the needle tip during blood removal / dialysis. And the lack of blood flow due to blood vessel conditions during blood removal / dialysis / returning blood.
　動脈側気泡センサ押さえ部材６７４は、図３及び図６に示すように、蓋部６２の閉鎖時において、ユニット本体６１に配置される動脈側気泡センサ受け部材６７２に対向して配置され、動脈側ライン２１を構成するチューブを押さえる。動脈側気泡センサ押さえ部材６７４の内部には、超音波受信部６７３が配置される。動脈側気泡センサ受け部材６７２の内部には、超音波発振部６７１が配置される。超音波受信部６７３及び超音波発振部６７１は、動脈側気泡センサ６７を構成する。動脈側気泡センサ６７は、動脈側ライン２１の内部を流通する液体中に含まれる気泡の有無を検知するセンサである。なお、超音波受信部６７３を動脈側気泡センサ受け部材６７２の内部に配置すると共に、超音波発振部６７１を動脈側気泡センサ押さえ部材６７４の内部に配置するように構成してもよい。 As shown in FIGS. 3 and 6, the arterial-side bubble sensor pressing member 674 is arranged so as to face the arterial-side bubble sensor receiving member 672 arranged in the unit main body 61 when the lid 62 is closed. Hold down the tubes that make up the line 21. An ultrasonic wave reception unit 673 is arranged inside the artery-side bubble sensor holding member 674. An ultrasonic oscillator 671 is arranged inside the arterial bubble sensor receiving member 672. The ultrasonic wave receiving unit 673 and the ultrasonic wave oscillating unit 671 form an artery side air bubble sensor 67. The arterial bubble sensor 67 is a sensor that detects the presence or absence of bubbles contained in the liquid flowing inside the artery line 21. The ultrasonic wave receiving unit 673 may be arranged inside the artery-side bubble sensor receiving member 672, and the ultrasonic wave oscillating unit 671 may be arranged inside the artery-side bubble sensor holding member 674.
　蓋部６２の閉鎖時に、動脈側気泡センサ押さえ部材６７４（図３参照）は、動脈側ライン２１を構成するチューブを動脈側気泡センサ受け部材６７２側に押し当てる。超音波受信部６７３は、超音波発振部６７１から発生される超音波が動脈側ライン２１を構成するチューブ内に流れる液体に照射されることで、液体と気泡の透過率の差を検出して気泡の有無を検知する。 When the lid 62 is closed, the arterial bubble sensor pressing member 674 (see FIG. 3) presses the tube forming the arterial line 21 against the arterial bubble sensor receiving member 672. The ultrasonic wave receiving unit 673 detects the difference in the transmittance between the liquid and the bubbles by irradiating the liquid flowing in the tube forming the artery side line 21 with the ultrasonic wave generated from the ultrasonic wave oscillating unit 671. Detects the presence of bubbles.
　動脈側下流チューブ押さえ部６０２の押さえ凸部６０２ｂは、蓋部６２の閉鎖時において、ユニット本体６１に配置される収容凹部６０２ａに対向して配置され、クランプユニット６０における動脈側ライン２１を流通する液体の下流側（図３における上方側）において、動脈側ライン２１を構成するチューブを押さえる。 The pressing convex portion 602b of the artery-side downstream tube pressing portion 602 is arranged so as to face the accommodating concave portion 602a arranged in the unit main body 61 when the lid portion 62 is closed, and circulates through the artery-side line 21 in the clamp unit 60. On the downstream side (upper side in FIG. 3) of the liquid, the tube forming the artery side line 21 is pressed.
　次に、蓋部６２の閉鎖時に、本体側静脈側チューブ配置部６１２及び蓋部側静脈側チューブ配置部６２２に設けられる構成について説明する。
　図３に示すように、蓋部６２の閉鎖時において、本体側静脈側チューブ配置部６１２及び蓋部側静脈側チューブ配置部６２２に沿って、静脈側上流チューブ押さえ部６０３、静脈側気泡センサ６８、静脈側クランプ部６９及び静脈側下流チューブ押さえ部６０４が配置される。本実施形態においては、静脈側上流チューブ押さえ部６０３、静脈側気泡センサ６８、静脈側クランプ部６９及び静脈側下流チューブ押さえ部６０４は、クランプユニット６０において、上流側から下流側（図１及び図３における上方側から下方側）に向かって、この順に並んで配置されている。 Next, the configuration provided in the main body side vein side tube placement portion 612 and the lid side vein side tube placement portion 622 when the lid portion 62 is closed will be described.
As shown in FIG. 3, when the lid portion 62 is closed, the vein side upstream tube pressing portion 603 and the vein side air bubble sensor 68 are arranged along the main body side vein side tube placement portion 612 and the lid side vein side tube placement portion 622. The vein side clamp section 69 and the vein side downstream tube holding section 604 are arranged. In the present embodiment, the vein-side upstream tube pressing portion 603, the vein-side bubble sensor 68, the vein-side clamping portion 69, and the vein-side downstream tube pressing portion 604 are arranged in the clamp unit 60 from the upstream side to the downstream side (FIG. 1 and FIG. 1). 3 are arranged in this order from the upper side to the lower side).
　本体側静脈側チューブ配置部６１２は、図３に示すように、ユニット本体６１の内面に配置される。本体側静脈側チューブ配置部６１２には、静脈側ライン２２を構成するチューブを流通する液体の上流側から下流側（図３の上方側から下方側）に向かって順に、静脈側上流チューブ押さえ部６０３の収容凹部６０３ａ、静脈側気泡センサ６８の超音波発振部６８１が内部に収容された静脈側気泡センサ受け部材６８２、静脈側クランプ部６９の静脈側可動クランプ部６９１、静脈側下流チューブ押さえ部６０４の収容凹部６０４ａが並んで配置される。 The main body side vein side tube arrangement portion 612 is arranged on the inner surface of the unit main body 61 as shown in FIG. The main body side venous tube placement section 612 has a venous side upstream tube holding section in order from the upstream side to the downstream side (from the upper side to the lower side in FIG. 3) of the liquid flowing through the tube forming the vein side line 22. An accommodation recess 603a of 603, a vein side bubble sensor receiving member 682 in which the ultrasonic oscillator 681 of the vein side bubble sensor 68 is accommodated, a vein side movable clamp part 691 of the vein side clamp part 69, a vein side downstream tube pressing part. The accommodation recesses 604a of 604 are arranged side by side.
　蓋部側静脈側チューブ配置部６２２は、蓋部６２の内面に配置され、蓋部６２の閉鎖時に本体側静脈側チューブ配置部６１２に対向して配置される。蓋部側静脈側チューブ配置部６２２には、静脈側ライン２２を構成するチューブを流通する液体の上流側から下流側（図３の上方側から下方側）に向かって順に、静脈側上流チューブ押さえ部６０３の押さえ凸部６０３ｂ、静脈側気泡センサ６８の超音波受信部６８３が内部に収容された静脈側気泡センサ押さえ部材６８４、静脈側クランプ部６９の静脈側クランプ受け部６９２、静脈側下流チューブ押さえ部６０４の押さえ凸部６０４ｂが並んで配置されている。 The lid-side vein-side tube placement portion 622 is placed on the inner surface of the lid portion 62, and is placed so as to face the main-body-side vein-side tube placement portion 612 when the lid portion 62 is closed. The lid-side vein-side tube placement portion 622 sequentially holds the vein-side upstream tube holder from the upstream side to the downstream side (from the upper side to the lower side in FIG. 3) of the liquid flowing through the tube forming the vein side line 22. The holding convex portion 603b of the portion 603, the vein side bubble sensor holding member 684 in which the ultrasonic wave receiving portion 683 of the vein side bubble sensor 68 is housed, the vein side clamp receiving portion 692 of the vein side clamp portion 69, and the vein side downstream tube. The pressing protrusions 604b of the pressing portion 604 are arranged side by side.
　静脈側上流チューブ押さえ部６０３の押さえ凸部６０３ｂは、蓋部６２の閉鎖時に、ユニット本体６１に配置される収容凹部６０３ａに対向して配置され、クランプユニット６０における静脈側ライン２２を流通する液体の上流側（図３における上方側）において、静脈側ライン２２を構成するチューブを押さえる。 The holding convex portion 603b of the vein side upstream tube holding portion 603 is arranged so as to face the housing concave portion 603a arranged in the unit main body 61 when the lid portion 62 is closed, and the liquid flowing through the vein side line 22 in the clamp unit 60. On the upstream side (upper side in FIG. 3) of, the tube forming the vein side line 22 is pressed.
　静脈側気泡センサ押さえ部材６８４は、蓋部６２の閉鎖時において、ユニット本体６１に配置される静脈側気泡センサ受け部材６８２に対向して配置され、静脈側ライン２２を構成するチューブを押さえる。静脈側気泡センサ押さえ部材６８４の内部には、超音波受信部６８３が配置される。静脈側気泡センサ受け部材６８２の内部には、超音波発振部６８１が配置される。超音波受信部６８３及び超音波発振部６８１は、静脈側気泡センサ６８を構成する。静脈側気泡センサ６８は、静脈側ライン２２の内部を流通する液体中に含まれる気泡の有無を検知するセンサである。なお、超音波受信部６８３を静脈側気泡センサ受け部材６８２の内部に配置すると共に、超音波発振部６８１を静脈側気泡センサ受け部材６８４の内部に配置するように構成してもよい。 The vein-side bubble sensor pressing member 684 is arranged so as to face the vein-side bubble sensor receiving member 682 arranged in the unit main body 61 when the lid 62 is closed, and presses the tube forming the vein-side line 22. An ultrasonic wave receiving unit 683 is arranged inside the vein-side bubble sensor holding member 684. An ultrasonic wave oscillating unit 681 is arranged inside the vein-side bubble sensor receiving member 682. The ultrasonic wave receiving unit 683 and the ultrasonic wave oscillating unit 681 form a vein side bubble sensor 68. The vein-side bubble sensor 68 is a sensor that detects the presence or absence of bubbles contained in the liquid flowing through the inside of the vein-side line 22. The ultrasonic wave receiving unit 683 may be arranged inside the vein side bubble sensor receiving member 682, and the ultrasonic wave generating unit 681 may be arranged inside the vein side bubble sensor receiving member 684.
　蓋部６２の閉鎖時に、静脈側気泡センサ押さえ部材６８４（図３参照）は、静脈側ライン２２を構成するチューブを静脈側気泡センサ受け部材６８２側に押し当てる。超音波受信部６８３は、超音波発振部６８１から発生される超音波が静脈側ライン２２を構成するチューブ内に流れる液体に照射されることで、液体と気泡の透過率の差を検出して気泡の有無を検知する。 When the lid portion 62 is closed, the vein side bubble sensor pressing member 684 (see FIG. 3) presses the tube forming the vein side line 22 against the vein side bubble sensor receiving member 682 side. The ultrasonic wave receiving unit 683 detects the difference in the transmittance between the liquid and the bubbles by irradiating the liquid flowing in the tube forming the vein side line 22 with the ultrasonic wave generated from the ultrasonic wave oscillating unit 681. Detects the presence of bubbles.
　静脈側クランプ受け部６９２は、蓋部６２の閉鎖時において、ユニット本体６１に配置される静脈側可動クランプ部６９１に対向して配置される。静脈側クランプ受け部６９２及び静脈側可動クランプ部６９１は、静脈側クランプ部６９を構成し、静脈側ライン２２を構成するチューブを挟んで保持する。 The vein side clamp receiving portion 692 is arranged to face the vein side movable clamp portion 691 arranged in the unit main body 61 when the lid portion 62 is closed. The vein side clamp receiving portion 692 and the vein side movable clamp portion 691 form the vein side clamp portion 69, and hold the tube forming the vein side line 22 by sandwiching the tube.
　静脈側クランプ部６９は、図３及び図７に示すように、ユニット本体６１に配置される静脈側可動クランプ部６９１と、ユニット本体６１に配置され静脈側可動クランプ部６９１を駆動するソレノイド６９３と、蓋部６２に配置される静脈側クランプ受け部６９２と、を有する。静脈側クランプ受け部６９２は、蓋部６２の内面から突出して形成され、幅方向Ｈに延びる。 As shown in FIGS. 3 and 7, the vein side clamp part 69 includes a vein side movable clamp part 691 arranged in the unit main body 61, and a solenoid 693 arranged in the unit main body 61 and driving the vein side movable clamp part 691. , And a vein-side clamp receiving portion 692 arranged on the lid portion 62. The vein side clamp receiving portion 692 is formed to project from the inner surface of the lid portion 62 and extends in the width direction H.
　静脈側可動クランプ部６９１は、先端が幅方向Ｈに延びる平面状に形成されると共にチューブ配置部が延びる方向に切断した断面において先端側の幅が狭い台形状に形成される。静脈側可動クランプ部６９１の後端には、ソレノイド６９３の出力軸６９３ａが、進退可能に接続されている。静脈側可動クランプ部６９１は、ソレノイド６９３の出力軸６９３ａの進退により、静脈側ライン２２を構成するチューブを、静脈側可動クランプ部６９１の先端及び静脈側クランプ受け部６９２の先端で挟み込んでクランプし、又は、静脈側ライン２２を開閉する。 The venous side movable clamp portion 691 has a tip end formed in a flat shape extending in the width direction H and a trapezoid shape having a narrow width on the tip end side in a cross section cut in the direction in which the tube placement portion extends. An output shaft 693a of a solenoid 693 is connected to the rear end of the vein side movable clamp portion 691 so as to be able to move forward and backward. The vein side movable clamp section 691 clamps the tube forming the vein side line 22 by sandwiching the tube forming the vein side line 22 between the tip of the vein side movable clamp section 691 and the tip of the vein side clamp receiving section 692 by advancing and retracting the output shaft 693a of the solenoid 693. Alternatively, the vein side line 22 is opened and closed.
　以上のように構成される静脈側クランプ部６９は、血液透析装置１の通常動作時に、静脈側可動クランプ部６９１及び静脈側クランプ受け部６９２により、ユニット本体６１と蓋部６２との間に配置される静脈側ライン２２を構成するチューブをクランプする。
　また、静脈側クランプ部６９は、静脈側気泡センサ６８または動脈側気泡センサ６７による気泡の検出結果に応じて制御される。静脈側クランプ部６９は、静脈側気泡センサ６８または動脈側気泡センサ６７により気泡が所定量よりも多く検出された場合に、静脈側可動クランプ部６９１を進出させて、静脈側ライン２２を構成するチューブを押し潰して、静脈側ライン２２の流路を閉鎖することで、静脈側気泡センサ６８よりも上流側において、チューブの内部を流通する液体の送液を停止させる。 The vein side clamp part 69 configured as described above is disposed between the unit main body 61 and the lid part 62 by the vein side movable clamp part 691 and the vein side clamp receiving part 692 during the normal operation of the hemodialysis apparatus 1. The tube forming the venous line 22 is clamped.
Further, the vein side clamp section 69 is controlled according to the detection result of the bubble by the vein side bubble sensor 68 or the artery side bubble sensor 67. The venous side clamp portion 69 configures the venous side line 22 by advancing the venous side movable clamp portion 691 when the venous side bubble sensor 68 or the arterial side bubble sensor 67 detects more bubbles than a predetermined amount. By crushing the tube and closing the flow path of the venous line 22, the liquid supply flowing through the inside of the tube is stopped on the upstream side of the venous bubble sensor 68.
　静脈側下流チューブ押さえ部６０４の押さえ凸部６０４ｂは、蓋部６２の閉鎖時において、ユニット本体６１に配置される収容凹部６０４ａに対向して配置され、クランプユニット６０における静脈側ライン２２を流通する液体の下流側（図３における下方側）において、静脈側ライン２２を構成するチューブを押さえる。 The pressing convex portion 604b of the vein side downstream tube pressing portion 604 is arranged so as to face the accommodation concave portion 604a arranged in the unit main body 61 when the lid portion 62 is closed, and circulates through the vein side line 22 in the clamp unit 60. On the downstream side (lower side in FIG. 3) of the liquid, the tube forming the vein side line 22 is pressed.
　以上のように構成されるクランプユニット６０は、動脈側ライン２１を構成するチューブ及び静脈側ライン２２を構成するチューブをユニット本体６１に配置した状態で、蓋部６２を閉鎖するだけで、クランプユニット６０においてチューブを確実にクランプすることができる。 The clamp unit 60 configured as described above is configured such that the tube forming the artery side line 21 and the tube forming the vein side line 22 are arranged in the unit main body 61, and the lid portion 62 is simply closed. The tube can be securely clamped at 60.
　制御装置５０は、情報処理装置（コンピュータ）により構成されており、制御プログラムを実行することにより、透析装置１の動作を制御する。制御装置５０は、各種工程の制御プログラムを実行することにより、血液透析装置１の動作を制御して運転する。具体的には、制御装置５０は、血液回路２０及び透析液回路３０に配置された各種のポンプやクランプ、並びにヒータ４０等の動作を制御して、血液透析装置１により行われる各種工程（プライミング工程、脱血工程、透析工程、補液工程、返血工程等）を実行する。 The control device 50 is composed of an information processing device (computer), and controls the operation of the dialysis device 1 by executing a control program. The control device 50 controls the operation of the hemodialysis device 1 to operate by executing control programs for various processes. Specifically, the control device 50 controls the operations of various pumps and clamps arranged in the blood circuit 20 and the dialysate circuit 30, the heater 40, and the like to perform various steps (priming) performed by the hemodialysis device 1. Process, blood removal process, dialysis process, fluid replacement process, blood return process, etc.).
　以上説明した本実施形態の血液透析装置１によれば、以下のような効果を奏する。 According to the hemodialysis apparatus 1 of the present embodiment described above, the following effects are obtained.
　（１）荷重検出部６６を、ユニット本体６１と、ユニット本体６１に取り付けられた基板６６４と、基板６６４に配置され、チューブからの圧力による荷重を検出するフォースセンサ６６５と、ユニット本体６１を開閉する蓋部６２と、蓋部６２によりユニット本体６１を閉じて蓋部６２とフォースセンサ６６５との間にチューブが配置された状態において、フォースセンサ６６５に所定値以上の荷重が掛かった場合に、フォースセンサ６６５を介して基板６６４に掛かった荷重を吸収する荷重吸収部８０と、を備えて構成した。
　そのため、チューブをユニット本体６１と蓋部６２との間に配置する際に、フォースセンサ６６５に許容荷重以上の荷重が掛かることを抑制できる。そのため、許容荷重未満の荷重が基板６６４に掛かった場合にチューブからの圧力によるフォースセンサ６６５の荷重の検出には影響を与えずに、フォースセンサ６６５に許容荷重以上の荷重が掛かることを抑制できる。これにより、フォースセンサ６６５の破損を抑制できる。 (1) The load detection unit 66 is provided with the unit main body 61, the substrate 664 attached to the unit main body 61, the force sensor 665 arranged on the substrate 664 to detect the load due to the pressure from the tube, and the unit main body 61 is opened and closed. When a load equal to or larger than a predetermined value is applied to the force sensor 665 in a state in which the unit body 61 is closed by the lid unit 62 and the tube is arranged between the lid unit 62 and the force sensor 665, And a load absorbing section 80 that absorbs the load applied to the substrate 664 via the force sensor 665.
Therefore, when the tube is arranged between the unit body 61 and the lid portion 62, it is possible to prevent the force sensor 665 from being applied with a load larger than the allowable load. Therefore, when a load less than the allowable load is applied to the substrate 664, the force sensor 665 can be prevented from being applied with a load larger than the allowable load without affecting the detection of the load of the force sensor 665 due to the pressure from the tube. . As a result, damage to the force sensor 665 can be suppressed.
　（２）荷重吸収部８０は、基板６６４を厚さ方向に貫通して配置され基板６６４を厚さ方向に移動可能に支持する棒状のガイドポスト８１と、フォースセンサ６６５に所定値以上の荷重が掛かった場合にフォースセンサ６６５に掛かった荷重を吸収する側への基板６６４の移動を許容しつつ、フォースセンサ６６５に所定値未満の荷重が掛かった場合にフォースセンサ６６５が検出位置に位置するように基板６６４を付勢するバネ部材８２と、を有する。そのため、許容荷重以上の荷重がフォースセンサ６６５に掛かった場合に、ガイドポスト８１により基板６６４が厚さ方向に移動可能にガイドされた状態で、バネ部材８２より基板６６４の厚さ方向への荷重を吸収することができる。これにより、簡易な構成で、フォースセンサ６６５に掛かる荷重を吸収できる。 (2) The load absorbing portion 80 has a rod-shaped guide post 81 that is arranged to penetrate the substrate 664 in the thickness direction and supports the substrate 664 so as to be movable in the thickness direction, and a force sensor 665 that applies a load of a predetermined value or more. When the load applied to the force sensor 665 is less than a predetermined value, the force sensor 665 is positioned at the detection position while allowing the substrate 664 to move to the side that absorbs the load applied to the force sensor 665 when applied. And a spring member 82 for urging the substrate 664. Therefore, when a force equal to or greater than the allowable load is applied to the force sensor 665, the load from the spring member 82 in the thickness direction of the substrate 664 is guided by the guide post 81 so that the substrate 664 can move in the thickness direction. Can be absorbed. This makes it possible to absorb the load applied to the force sensor 665 with a simple configuration.
　（３）２組のバネ部材８２及びガイドポスト８１は、基板６６４の面方向におけるフォースセンサ６６５が配置された部分を挟んだ２箇所に配置される。これにより、フォースセンサ６６５を挟んだ２箇所において、２組のバネ部材８２及びガイドポスト８１により、基板６６４の厚さ方向への荷重を吸収できる。よって、フォースセンサ６６５に掛かる荷重を安定して吸収させることができる。 (3) The two sets of spring members 82 and guide posts 81 are arranged at two positions in the plane direction of the substrate 664, sandwiching the part where the force sensor 665 is arranged. As a result, the load in the thickness direction of the substrate 664 can be absorbed by the two sets of the spring member 82 and the guide post 81 at two positions sandwiching the force sensor 665. Therefore, the load applied to the force sensor 665 can be stably absorbed.
　（４）荷重吸収部８０は、２つのガイドポスト８１を接続する接続部材８３を更に有する。これにより、２つのガイドポスト８１の平行状態を保つことができ、２つのガイドポスト８１にガイドされる基板６４４を厚さ方向にスムーズに移動させることができる。これにより、フォースセンサ６６５に掛かる荷重を安定して吸収させることができる。 (4) The load absorbing portion 80 further includes a connecting member 83 that connects the two guide posts 81. As a result, the two guide posts 81 can be kept parallel to each other, and the substrate 644 guided by the two guide posts 81 can be smoothly moved in the thickness direction. Thereby, the load applied to the force sensor 665 can be stably absorbed.
　以上、本発明の血液透析装置の好ましい各実施形態について説明したが、本発明は、上述した実施形態に制限されるものではなく、適宜変更が可能である。
　例えば、前記実施形態においては、ガイドポスト８１（ガイド部材）及びバネ部材８２（付勢部材）を２組で構成したが、これに限定されず、１組又は３組以上で構成してもよい。 Although the preferred embodiments of the hemodialysis apparatus of the present invention have been described above, the present invention is not limited to the above-described embodiments and can be modified as appropriate.
For example, in the above embodiment, the guide post 81 (guide member) and the spring member 82 (biasing member) are configured in two sets, but the configuration is not limited to this, and one set or three or more sets may be configured. .
　また、前記実施形態においては、接続部材８３により、２つのガイドポスト８１を接続するように構成したが、接続部材８３を備えなくてもよい。 In addition, in the above-described embodiment, the connection member 83 is configured to connect the two guide posts 81, but the connection member 83 may not be provided.
　また、前記実施形態においては、フォースセンサ６６５（荷重検出センサ）を実装した基板６４４をユニット本体６１の外面に配置したが、これに限定されない。例えば、ユニット本体６１の内面に窪んだ部分を形成し、ユニット本体６１の内面の窪んだ部分に、フォースセンサ６６５（荷重検出センサ）を実装した基板６４４を配置してもよい。 Further, in the above-described embodiment, the board 644 on which the force sensor 665 (load detection sensor) is mounted is arranged on the outer surface of the unit body 61, but the invention is not limited to this. For example, a recessed portion may be formed on the inner surface of the unit body 61, and the substrate 644 on which the force sensor 665 (load detection sensor) is mounted may be arranged in the recessed portion on the inner surface of the unit body 61.
　１　血液透析装置（透析装置）
　６１　ユニット本体
　６２　蓋部
　６６　荷重検出部（閉塞検知装置）
　８０　荷重吸収部
　８１　ガイドポスト（ガイド部材）
　８２　バネ部材（付勢部材）
　８３　接続部材
　６６４　基板
　６６５　フォースセンサ（荷重検出センサ） 1 Hemodialysis machine (dialysis machine)
61 unit main body 62 lid 66 load detector (blockage detector)
80 load absorbing part 81 guide post (guide member)
82 Spring member (biasing member)
83 connection member 664 substrate 665 force sensor (load detection sensor)

Claims (5)

  1. 　ユニット本体と、
    　前記ユニット本体に取り付けられた基板と、
    　前記基板に配置され、チューブからの圧力による荷重を検出する荷重検出センサと、
    　前記ユニット本体を開閉する蓋部と、
    　前記蓋部により前記ユニット本体を閉じて前記蓋部と前記荷重検出センサとの間に前記チューブが配置された状態において、前記荷重検出センサに所定値以上の荷重が掛かった場合に、前記荷重検出センサを介して前記基板に掛かった荷重を吸収する荷重吸収部と、を備える閉塞検知装置。     Unit body,
    A substrate attached to the unit body,
    A load detection sensor which is arranged on the substrate and detects a load due to pressure from the tube,
    A lid for opening and closing the unit body,
    The load detection is performed when a load of a predetermined value or more is applied to the load detection sensor in a state where the unit main body is closed by the cover and the tube is arranged between the cover and the load detection sensor. A blockage detection device, comprising: a load absorption unit that absorbs a load applied to the substrate via a sensor.
  2. 　前記荷重吸収部は、
    　　前記基板を厚さ方向に貫通して配置され前記基板を厚さ方向に移動可能に支持する棒状のガイド部材と、
    　　前記荷重検出センサに所定値以上の荷重が掛かった場合に前記荷重検出センサに掛かった荷重を吸収する側への前記基板の移動を許容しつつ、前記荷重検出センサに所定値未満の荷重が掛かった場合に前記荷重検出センサが検出位置に位置するように前記基板を付勢する付勢部材と、を有する請求項１に記載の閉塞検知装置。     The load absorbing section,
    A rod-shaped guide member that is arranged to penetrate the substrate in the thickness direction and movably supports the substrate in the thickness direction,
    When the load detection sensor is loaded with a load of a predetermined value or more, the load detection sensor receives a load of less than a predetermined value while allowing the substrate to move to the side that absorbs the load applied to the load detection sensor. The blocking detection device according to claim 1, further comprising: a biasing member that biases the substrate so that the load detection sensor is located at the detection position when the load detection sensor is located.
  3. 　前記付勢部材は、２つのバネ部材で構成され、
    　前記ガイド部材は、２つ設けられ、
    　前記バネ部材及び前記ガイド部材を１組として、２組の前記バネ部材及び前記ガイド部材は、前記基板の面方向における前記荷重検出センサが配置された部分を挟んだ２箇所に配置される請求項２に記載の閉塞検知装置。     The biasing member includes two spring members,
    Two guide members are provided,
    2. The spring member and the guide member are set as one set, and two sets of the spring member and the guide member are arranged at two positions sandwiching a portion where the load detection sensor is arranged in the surface direction of the substrate. The blockage detection device according to 2.
  4. 　前記荷重吸収部は、前記２つのガイド部材を接続する接続部材を更に有する請求項３に記載の閉塞検知装置。 The blockage detecting device according to claim 3, wherein the load absorbing portion further includes a connecting member that connects the two guide members.
  5. 　請求項１～４のいずれかに記載の閉塞検知装置を備え、
    　前記ユニット本体と前記蓋部との間にチューブを配置することでチューブをクランプするクランプユニット。     A blockage detection device according to any one of claims 1 to 4,
    A clamp unit for clamping a tube by disposing the tube between the unit body and the lid.
PCT/JP2019/040909 2018-10-19 2019-10-17 Closure detection device and clamp unit WO2020080468A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201980058388.1A CN112654379B (en) 2018-10-19 2019-10-17 Occlusion detection device and clamping unit

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018197891A JP7176345B2 (en) 2018-10-19 2018-10-19 Obstruction detector and clamp unit
JP2018-197891 2018-10-19

Publications (1)

Publication Number Publication Date
WO2020080468A1 true WO2020080468A1 (en) 2020-04-23

Family

ID=70283914

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2019/040909 WO2020080468A1 (en) 2018-10-19 2019-10-17 Closure detection device and clamp unit

Country Status (3)

Country Link
JP (1) JP7176345B2 (en)
CN (1) CN112654379B (en)
WO (1) WO2020080468A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04346044A (en) * 1991-05-23 1992-12-01 Kanegafuchi Chem Ind Co Ltd Pillow-type pressure sensor
WO2017086456A1 (en) * 2015-11-20 2017-05-26 テルモ株式会社 Medical pump and control method therefor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003303999A1 (en) * 2003-01-30 2004-09-30 Jms Co., Ltd. Pressure detector and pressure detecting method
EP2000790B1 (en) * 2006-03-29 2012-09-12 JMS Co., Ltd. Pressure detection device
US8495918B2 (en) * 2010-10-20 2013-07-30 Medtronic Minimed, Inc. Sensor assembly and medical device incorporating same
JP5976302B2 (en) * 2011-11-16 2016-08-23 株式会社トップ Pressure detection device
JP5587958B2 (en) * 2012-10-19 2014-09-10 日機装株式会社 Ironing type pump
DE102017113398A1 (en) * 2017-06-19 2018-06-21 Fresenius Medical Care Deutschland Gmbh Door of a medical sensor device, medical sensor device and medical treatment device

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04346044A (en) * 1991-05-23 1992-12-01 Kanegafuchi Chem Ind Co Ltd Pillow-type pressure sensor
WO2017086456A1 (en) * 2015-11-20 2017-05-26 テルモ株式会社 Medical pump and control method therefor

Also Published As

Publication number Publication date
JP7176345B2 (en) 2022-11-22
CN112654379A (en) 2021-04-13
CN112654379B (en) 2023-09-26
JP2020065558A (en) 2020-04-30

Similar Documents

Publication Publication Date Title
JP6813484B2 (en) Blood purification device
JP2004313522A (en) Dialyzer
WO2014076519A1 (en) Extracorporeal blood treatment device
JP6888433B2 (en) Dialysis machine
JP6571234B1 (en) Blood purification equipment
WO2020080468A1 (en) Closure detection device and clamp unit
US11554202B2 (en) Blood purification apparatus and method of discharging bubbles therefrom
WO2020080466A1 (en) Load detector and clamp unit
JP7132093B2 (en) blood purifier
JP6671159B2 (en) Blood purification device
CN110662564B (en) Clamp unit and dialysis apparatus provided with same
WO2018230399A1 (en) Dialysis device
JP7392345B2 (en) blood purification device
JP7298244B2 (en) Sensor clip and liquid component measuring device
JP2019187789A (en) Replenishment control method, control device and dialyzer
JP2019000167A (en) Dialyzer
JPH06327768A (en) Blood component separating device
JP2011182822A (en) Fixing member, medical instrument, medical fluid storage bag, and blood purifier

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 19874034

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 19874034

Country of ref document: EP

Kind code of ref document: A1