WO2020076018A1 - Applicateur de microstructure - Google Patents

Applicateur de microstructure Download PDF

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Publication number
WO2020076018A1
WO2020076018A1 PCT/KR2019/013074 KR2019013074W WO2020076018A1 WO 2020076018 A1 WO2020076018 A1 WO 2020076018A1 KR 2019013074 W KR2019013074 W KR 2019013074W WO 2020076018 A1 WO2020076018 A1 WO 2020076018A1
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WO
WIPO (PCT)
Prior art keywords
microstructure
drug
liquid
skin
plate
Prior art date
Application number
PCT/KR2019/013074
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English (en)
Korean (ko)
Inventor
정형일
양휘석
김현준
장민규
Original Assignee
연세대학교 산학협력단
주식회사 주빅
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020180119648A external-priority patent/KR102215571B1/ko
Priority claimed from KR1020190116617A external-priority patent/KR102174568B1/ko
Application filed by 연세대학교 산학협력단, 주식회사 주빅 filed Critical 연세대학교 산학협력단
Publication of WO2020076018A1 publication Critical patent/WO2020076018A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Definitions

  • the present invention relates to a microstructure applicator.
  • a number of drugs and therapeutic agents have been developed for the treatment of diseases, but in delivering drugs into the body, problems with passage of biological barriers (e.g., skin, oral mucosa and brain-vessel barriers) and efficiency of drug delivery Still remains to be improved.
  • biological barriers e.g., skin, oral mucosa and brain-vessel barriers
  • Drugs are generally orally administered in tablet or capsule form, but a number of drugs cannot be effectively delivered by the above administration method alone due to reasons such as digestion or absorption in the gastrointestinal tract or loss by the mechanism of the liver. Moreover, some drugs cannot effectively spread through the intestinal mucosa. In addition, patient compliance is also a problem, for example, in critically ill patients who need to take medication at specific intervals or who cannot take medication.
  • Microstructures developed to date have been mainly used for drug delivery in vivo, blood collection, and analyte detection in the body.
  • the existing biodegradable microstructures or microstructures required a separate adhesive sheet to adhere to the skin and fix it for a long time. Due to the use of the adhesive sheet, the user may feel a foreign body sensation and an allergic reaction may occur. In addition, there is a problem in that there is a limit to the application to the skin with severe joints, flexed skin, or hairy skin.
  • one embodiment of the present invention is to provide a microstructure applicator capable of simultaneously applying a microstructure and a liquid drug.
  • one embodiment of the present invention is to provide a microstructure applicator that can promote the action of the microstructure in the skin while reducing pain when used.
  • the main body A microstructure embedded in the main body or coupled to the lower side and including a first drug; And a liquid supply unit provided in the main body and supplying a liquid second drug, wherein the liquid second drug is applied to the surface of the skin before or after the microstructure is implanted into the skin.
  • An applicator is provided.
  • the microstructure applicator is provided in the main body, a pressing member for pressing the microstructure; And a button portion for sequentially or independently pressing the pressing member and the liquid supplying portion by external force, wherein the main body is a hollow body, coupled to one side of the body, and at least one through hole is formed.
  • the main body is a hollow body, coupled to one side of the body, and at least one through hole is formed.
  • An upper cover portion and a lower cover portion coupled to the other side of the body and having a plurality of openings formed therein, the liquid supply portion is formed with an outlet at its lower side, and the pressing member pressurizes the microstructure to the plurality of opening sides.
  • the liquid supply unit when the button portion is pressed at a first depth, the liquid supply unit is pressed so that the liquid second drug is discharged to the surface of the skin, and when pressed at a second depth greater than the first depth, the microstructure The pressing member may be pressed to be implanted into the skin.
  • the pressing member is a plate-shaped first plate; And a plurality of pressurized protrusions protruding from the first plate toward the lower cover portion, and the microstructure is formed at one end.
  • the pressing member when the button portion is pressed at a first depth, the pressing member is pressed so that the microstructure is implanted into the skin, and when pressed at a second depth greater than the first depth, the second drug in the liquid is the skin.
  • the liquid supply may be pressed to discharge to the surface.
  • the pressing member is a plate-shaped first plate; A plurality of pressurized protrusions protruding from the first plate toward the lower cover part and having the microstructure formed at one end; And an extension part extending one side of the first plate and the button part.
  • the microstructure applicator is provided on the lower side of the liquid supply unit to discharge or block the liquid second drug as at least one of the plurality of openings as the liquid supply unit is pressed and moved toward the plurality of openings. It may further include an opening and closing portion.
  • the liquid supply unit accommodates the second drug in the liquid and the receiving portion is formed on the bottom surface of the outlet; And a flow path portion connecting at least one of the plurality of openings from the outlet, and the receiving portion can be movably disposed outside the flow path through the outlet.
  • the plurality of openings may include a plurality of first openings through which the microstructure is shot and at least one second opening through which the liquid second drug is discharged.
  • the lower cover portion may communicate with the at least one second opening to form at least one flow path having a groove shape having a predetermined depth.
  • the plurality of first openings and the at least one second opening are arranged in an array, the at least one second opening is disposed between the plurality of first openings, and the lower cover part is A side wall may be formed along the outer periphery of the lower surface.
  • the microstructure is provided in the microstructure module
  • the body is the microstructure module is coupled to the lower side
  • the microstructure is inserted into the skin by an external force by the user
  • the liquid supply unit is the upper side of the body It is provided on and supplies the second liquid medicament to the microstructure module side
  • the liquid second medicament is applied on the skin after the microstructure is implanted into the skin, and the skin penetrates, dissolves, and within the microstructure. At least one of diffusion and absorption into the skin.
  • the microstructure module includes a plate-like support plate in which a through hole coupled to the main body is provided at the center, and micro-protrusions are projected downward at regular intervals, and the micro-structure is the micro-projections. It can be formed on.
  • the second drug in the liquid may flow out through the first flow path formed by the fine protrusions and flow out through the through-hole to be applied to the skin.
  • the support plate is provided with a second flow path orthogonal to the through-hole in the support plate, and the second flow path can communicate with the microscopic projections.
  • the body comprises a handle for the user to hold; A seating part provided inside the handle part and mounted with the liquid supply part; A plate-shaped support part protruding downward from which the microstructure module is coupled; An extension portion extending the support portion and the handle portion; And a flow path portion formed from the seating portion to the coupling portion and through which the liquid second drug flows.
  • the liquid supply unit is a receiving unit for receiving the second drug of the liquid; And a drawing portion for flowing the liquid second drug through the main body, and the receiving portion may flow the liquid second drug into the drawing portion in a dropper manner.
  • the liquid second drug may be repeatedly supplied at regular time intervals.
  • the liquid second drug may include at least one of minoxidil, triamcinolone and finasteride.
  • the liquid supply unit may be integrally provided with the main body or detachably provided with the main body.
  • the microstructure applicator according to an embodiment of the present invention can maximize the drug delivery efficiency by improving the dissolution rate of the microstructure by applying a substance that helps dissolution of the microstructure to the skin before and after implantation of the microstructure.
  • the microstructure applicator by applying a liquid drug on the surface of the skin immediately before the microstructure is implanted into the skin, the drug contained in the microstructure can be delivered deeper to the skin. Therefore, the efficacy of drug delivery can be improved.
  • microstructure applicator according to an embodiment of the present invention can use the microstructure and the liquid drug together, so that the microstructure and the liquid drug can be applied to the skin at the same time. Can be reduced.
  • microstructure applicator can diversify the type of delivery drug because the drug, which is difficult to manufacture with the microstructure, is applied in a liquid state together with the microstructure.
  • the microstructure applicator according to an embodiment of the present invention is a drug because it can promote the permeation, dissolution, diffusion, and absorption of the microstructure by introducing a second drug to assist the action of the microstructure after the microstructure is inserted into the skin. It can improve the efficacy of delivery.
  • microstructure applicator according to an embodiment of the present invention is inserted into the skin by the user's pressing force, thereby reducing the pain of the user, thereby improving user convenience.
  • FIG. 1 is a cross-sectional view showing a microstructure applicator according to a first embodiment of the present invention
  • Figure 2 is a cross-sectional view showing a state in which the button portion is pressed to the first depth in Figure 1,
  • FIG. 3 is a cross-sectional view showing a state in which the button portion is pressed to the second depth in FIG. 2,
  • FIG. 4 is a plan view showing various examples of the lower cover part in FIG. 1;
  • FIG. 5 is a perspective view showing various examples in which a flow path is formed in the lower cover part in FIG. 1;
  • Figure 6 is a perspective view showing an example of the lower cover portion in Figure 1,
  • Figure 7 is a perspective view showing another example of the lower cover portion in Figure 1,
  • FIG. 9 is a cross-sectional view showing a microstructure applicator according to a second embodiment of the present invention.
  • FIG. 10 is a cross-sectional view showing a state in which the first button is pressed in FIG. 9,
  • FIG. 11 is a cross-sectional view showing a state in which the second button is pressed in FIG. 9,
  • FIG. 12 is a cross-sectional view showing a microstructure applicator according to a third embodiment of the present invention.
  • FIG. 13 is a cross-sectional view showing a state in which the button portion is pressed to the first depth in FIG. 12,
  • FIG. 14 is a cross-sectional view showing a state in which the button portion is pressed to the second depth in FIG. 12,
  • FIG. 15 is a cross-sectional view showing a microstructure applicator according to a fourth embodiment of the present invention.
  • FIG. 16 is a cross-sectional view showing a state in which the first button portion is pressed in FIG. 15,
  • FIG. 17 is a cross-sectional view showing a state in which the second button is pressed in FIG. 15,
  • FIG. 18 is a perspective view of a microstructure applicator according to a fifth embodiment of the present invention.
  • FIG. 19 is an exploded perspective view of FIG. 18,
  • FIG. 20 is a cross-sectional view of the body of FIG. 18,
  • FIG. 21 is a perspective view of the body of FIG. 18,
  • FIG. 22 is a cross-sectional view of an example of the microstructure module of FIG. 18,
  • FIG. 23 is a cross-sectional view of another example of the microstructure module of FIG. 18,
  • FIG. 24 is a cross-sectional view showing a state in which the microstructure is inserted into the skin by the microstructure applicator according to the fifth embodiment of the present invention.
  • 25 is a cross-sectional view showing a state in which the second drug is applied to the skin after FIG. 24.
  • FIG. 1 is a cross-sectional view showing a microstructure applicator according to a first embodiment of the present invention
  • FIG. 2 is a cross-sectional view showing a state in which the button portion is pressed to a first depth in FIG. 1
  • FIG. 3 is a button portion in FIG. It is a sectional view showing a state pressed to a second depth.
  • the microstructure applicator 100 includes a body 110, a pressing member 120, a liquid supply unit 130, an opening / closing unit 140, and a button unit 150.
  • This microstructure applicator 100 is for shooting to implant the microstructure 10 into the skin 1 by pressure applied from the outside.
  • shooting means that the microstructure 10 is separated from the microstructure applicator 100 and moves forward.
  • the present invention is to apply the liquid second drug 20, which is difficult to manufacture with the microstructure 10, with the shooting of the microstructure 10 to the skin 1. That is, the microstructure applicator 100 is for applying the liquid second drug 20 on the surface of the skin 1 before or after the microstructure 10 is implanted into the skin.
  • the application of the liquid second drug 20 before the microstructure 10 corresponds to the first and second embodiments
  • the liquid second drug 20 is applied to the microstructure 10 Applying later is equivalent to the third and fourth embodiments.
  • Drugs that can be used in the microstructure 10 in the present invention are not particularly limited.
  • the drug may include chemical drugs, protein drugs, peptide drugs, nucleic acid molecules for gene therapy, nanoparticles, functional cosmetic active ingredients, and cosmetic ingredients.
  • drugs that can be used in the present invention for example, anti-inflammatory drugs, analgesics, anti-arthritis agents, antispasmodics, antidepressants, antipsychotic drugs, neurostabilizers, anti-anxiety drugs, drug antagonists, anti-Parkins disease drugs, cholinergic agonists, Anti-cancer drugs, anti-angiogenesis inhibitors, immunosuppressants, antiviral agents, antibiotics, appetite suppressants, analgesics, anticholinergics, antihistamines, antimigraine agents, hormones, coronary vessels, cerebrovascular or peripheral vasodilators, contraceptives, antithrombotic agents, diuretics , Antihypertensive agents, cardiovascular disease treatment agents, cosmetic ingredients (eg, wrinkle improvement agents, skin aging inhibitors and skin whitening agents), but are not limited thereto.
  • cosmetic ingredients eg, wrinkle improvement agents, skin aging inhibitors and skin whitening agents
  • the material forming the microstructure 10 in the present invention includes a biocompatible or biodegradable material.
  • biocompatible material refers to a material that is substantially non-toxic to the human body, chemically inert, and non-immunogenic.
  • biodegradable substance refers to a substance that can be degraded in vivo by body fluids or microorganisms.
  • the microstructure 10 may be formed by spotting a viscous composition of the above drugs.
  • viscous composition refers to a composition having the ability to form a microstructure by changing shape.
  • the liquid second drug 20 functions as an auxiliary agent to help dissolution or drug delivery of the microstructure 10.
  • the microstructure 10 is dissolved more rapidly in the skin 1, or the microstructure
  • the drug delivery efficiency from (10) to the skin (1) can be maximized, and thus the drug delivery time by the microstructure (10) can be reduced.
  • the liquid second drug 20 may be a drug that is difficult to form into the microstructure 10 in the same manner as spotting by a viscous composition.
  • the liquid second drug 20 may include not only medical drugs, but also cosmetic ampoules.
  • the type of drug delivered to the skin 1 is not limited to the microstructure 10 as a medium for delivering the drug.
  • the microstructure applicator 100 is for transplanting the microstructure 10 into the skin 1 after applying the liquid second drug 20 to the skin 1.
  • the button unit 150 is the first pressing step when pressed to the first depth, pressurizing the liquid supply unit 130 so that the liquid second drug 20 is discharged to the surface of the skin 1, the second When pressed to the depth, the pressing member 120 may be pressed so that the microstructure 10 is implanted into the skin 1 as a second pressing step.
  • the second depth may be greater than the first depth.
  • the body 110 may include an upper cover portion 112, a lower cover portion 114 and a body 116.
  • the upper cover part 112 is coupled to the upper side of the body 116, and a through hole 112a may be formed.
  • the through hole 112a may be inserted such that one side of the button portion 150 as described later protrudes outward.
  • the lower cover portion 114 is coupled to the lower side of the body 116 and a plurality of openings 114a and 114b may be formed.
  • the openings 114a and 114b include a plurality of first openings 114a through which the microstructure 10 is shot, and at least one second opening 114b through which the liquid second drug 20 is discharged.
  • the lower cover portion 114 may have a flow path 114c communicating with the second opening 114b at its lower surface.
  • the side wall 114d may be formed along the outer periphery of the lower cover portion 114.
  • the body 116 may be formed in a hollow shape. That is, the body 116 may accommodate a pressing member 120, a liquid supply unit 130, an opening / closing unit 140, and a button unit 150 therein.
  • the pressing member 120 is provided in the main body 110 to press the microstructure 10 toward the first opening 114a, a plurality of pressing protrusions 122, a first plate 124 and a first elastic member (126).
  • the pressing protrusion 122 may be provided in plural, and may be formed to protrude from the first plate 124 toward the lower cover portion 114.
  • the microscopic structure 10 may be formed at one end toward the lower cover portion 114 of the pressing protrusion 122.
  • the pressing protrusion 122 may be provided interchangeably. That is, at least one of the microstructure 10 and the pressing projection 122 may be formed for a single use. In addition, only the microstructure 10 may be provided to be replaceable.
  • the first plate 124 is formed in a plate shape and may be disposed to be movable in the vertical direction within the body 116.
  • the first plate 124 may have a plurality of pressing protrusions 122 formed on one surface facing the lower cover portion 114.
  • the first elastic member 126 may be disposed between the first plate 124 and the lower cover portion 114.
  • the first elastic member 126 may restore the first plate 124 pressed by an external force to its original position.
  • the first elastic member 126 may be provided outside the pressure projection 122, but is not particularly limited thereto.
  • the liquid supply unit 130 is for supplying the liquid second drug 20, and may include a receiving unit 132 and a flow path unit 136.
  • the receiving portion 132 has a constant receiving space formed therein, and can accommodate the second drug 20 in a liquid state.
  • the receiving portion 132 may be formed with a discharge port 134 for discharging the liquid second drug 20 on its bottom surface.
  • the flow path portion 136 may connect at least one second opening 114b from the outlet 134 of the receiving portion 132. That is, the flow path portion 136 is provided on the lower side of the receiving portion 132 and the outside may be disposed to be inserted into the outlet 134. At this time, the flow path portion 136 is one end is formed only to approximately the center of the outlet, 134 does not extend to the inner bottom surface of the receiving portion 132.
  • the receiving portion 132 may be disposed to be movable in the vertical direction through the outlet 134 from the outside of the flow path portion 136.
  • the opening / closing part 140 is for discharging or blocking the liquid second drug 20 from the liquid supply part 130, and may include a blocking part 142 and a support part 144.
  • the blocking portion 142 may be formed larger than the width of the outlet 134 formed on the lower surface of the receiving portion 132. That is, the blocking portion 142 is disposed on the upper surface of the discharge port 134 to block the discharge of the liquid second drug 20.
  • the support part 144 may be formed to extend from the lower side of the blocking part 142 to the lower cover part 114. That is, the support part 144 may be disposed to be coupled to each of the blocking part 142 and the lower cover part 114. Here, the support portion 144 may be disposed inside the flow path portion 136.
  • the liquid supply unit 130 is pressed and moves vertically toward the lower cover portion 114, the bottom surfaces of the blocking portion 142 and the receiving portion 132 are separated, so that the liquid second drug 20 is at least. It may be discharged through one second opening 114b.
  • the button unit 150 is for sequentially pressing the pressing member 120 and the liquid supply unit 130 by external force, and the pressing unit 152, the second plate 154, the protrusion 156, and the second elastic member 158.
  • the pressing portion 152 may protrude outward through the through hole 112a of the main body 110.
  • the pressing portion 152 may be a portion to which an external force is applied by the user.
  • the second plate 154 is formed on one side of the pressing portion 152 and may be disposed to be movable in the vertical direction within the body 110.
  • the second plate 154 is formed in a plate shape and may pressurize the liquid supply unit 130 by an external force through the pressing unit 152. That is, the second plate 154 may be directly or indirectly connected to the upper end of the receiving portion 132 through one surface facing the liquid supply unit 130.
  • the protrusion 156 may protrude from the bottom surface of the second plate 154 toward the first plate 124. At this time, the protrusion 156 may be formed to be spaced apart from the first plate 124 at a predetermined interval. Therefore, the external force is not transmitted to the first plate 124 until the protrusion 156 reaches the first plate 124. That is, the distance between the protrusion 156 and the first plate 124 may correspond to the first depth by the first pressing of the pressing portion 152.
  • the second elastic member 158 may be disposed between the first plate 124 and the second plate 154.
  • the second elastic member 158 may restore the second plate 154 pressed by external force to its original position.
  • the second elastic member 158 may be provided outside the receiving portion 132, but is not particularly limited thereto.
  • FIG. 4 is a plan view showing various examples of the lower cover portion in FIG. 1
  • FIG. 5 is a perspective view showing various examples in which a flow path is formed in the lower cover portion in FIG. 1
  • FIG. 6 is an example of the lower cover portion in FIG.
  • FIG. 7 is a perspective view showing another example of the lower cover portion in FIG. 1
  • FIG. 8 is a perspective view showing another example of the lower cover portion.
  • the plurality of first openings 114a and at least one second opening 114b may be arranged in an array form on the lower surface of the lower cover portion 114. That is, each of the first opening 114a and the second opening 114b may be disposed at equal intervals in the first direction and at equal intervals in the second direction perpendicular to the first direction. At this time, the second opening 114b may be disposed between the first opening 114a.
  • the second opening 114b may be formed in the center of the four first openings 114a (see FIG. 4 (a)).
  • only one second opening 114b may be formed in the center of the lower cover portion 1141 (see FIG. 4B).
  • the second opening 114b may be formed in a corner at the lower cover portion 1142 (see FIG. 4 (c)).
  • the first opening 114a may be formed in a cross shape with respect to the center.
  • the microstructure 10 is shot in the first opening 114a, and the second drug 20 in the liquid state may be discharged in the second opening 114b.
  • the lower cover portions 1143 to 1145 may have at least one flow path having a groove shape having a constant depth communicating with at least one second opening 114b.
  • the flow path 1143c may be formed in both directions of the first direction and the second direction around the second opening 114b at the lower surface of the lower cover portion 1143 (see FIG. 5 (a)), At this time, as shown in FIG. 7, the flow path 1147c may be formed in a groove shape having a predetermined depth from the lower surface of the lower cover portion 1147.
  • the flow path 1146c may be formed only in one of the first direction and the second direction about the second opening 114b at the lower surface of the lower cover portion 1146. It might be.
  • the lower cover portion 1143 may be formed with side walls 1143d along the outer periphery so that the liquid second drug 20 does not flow out of the microstructure applicator 100 (FIG. 5 (a)) Reference).
  • the flow path 1144c may be formed in the first direction and the second direction around one second opening 114b formed in the center of the lower cover portion 1144 (FIG. 5B) Reference). That is, the flow path 1144c may be formed in a cross shape on the lower surface of the lower cover portion 1144. Thereby, the liquid second drug 20 may be transferred from the second opening 114b to the four sides of the lower cover portion 1144.
  • the lower cover portions 1145 and 1148 may have sidewalls 1145d and 1148d along the outer periphery of its lower surface instead of forming a groove-shaped flow path (FIGS. 5 (c) and 8). Reference). That is, the lower cover portions 1145 and 1148 may be formed with flow paths 1145c and 1148c in a space corresponding to the heights of the side walls 1145d and 1148d. Thereby, the flow path is formed over the entire lower surface of the microstructure applicator 100, so that the liquid second drug 20 can be applied to the skin 1 more efficiently.
  • the liquid supply unit 130 may be pressed by the second plate 154 to move vertically toward the lower cover unit 114 side.
  • the bottom surface of the receiving portion 132 is positioned equal to or lower than one end of the flow path portion 136. Therefore, by blocking the blocking portion 142 from the bottom surface of the receiving portion 132, the liquid second drug 20 may be discharged to the flow path portion 136 through the discharge port 134.
  • the liquid second drug 20 may be discharged through at least one second opening 114b communicating with the flow path portion 136. Therefore, the discharged liquid drug 20 'may be applied on the surface of the skin 1 through the flow path 114c.
  • the button unit 150 may be maintained at a first depth until all of the liquid second drug 20 accommodated in the receiving unit 132 is discharged.
  • the protrusion 156 formed on the lower surface of the second plate 154 may reach the first plate 124. That is, before the protruding portion 156 reaches the first plate 124, the pressing member 120 is not pressed, and only the liquid supply unit 130 is pressed by the second plate 154, so that the liquid drug 20 ' ) May be first applied to the surface of the skin 1.
  • the pressing protrusion 122 vertically moves toward the lower cover portion 114, so that the microstructure 10 protrudes outward of the first opening 114a and the skin 1 ).
  • the drug in the liquid improves the dissolution rate of the microstructure
  • the drug contained in the microstructure can be delivered deeper to the skin, and thus the efficacy of drug delivery can be improved.
  • the microstructure applicator of the present invention is provided with two button portions to independently press the liquid supply and the pressing member.
  • the microstructure applicator 200 according to the second embodiment of the present invention may include a first button portion and a second button portion 256.
  • the same components as the first embodiment use the same reference numerals, and detailed descriptions thereof will be omitted.
  • FIG. 9 is a cross-sectional view showing a microstructure applicator according to a second embodiment of the present invention
  • FIG. 10 is a cross-sectional view showing a state in which the first button portion is pressed in FIG. 9
  • FIG. 11 is a second button portion in FIG. It is a sectional view showing a pressed state.
  • the microstructure applicator 200 may include a main body 210, a pressing member 120, a liquid supply unit 130, an opening / closing unit 140, and a button unit 250.
  • the pressing member 120, the liquid supply unit 130 and the opening and closing unit 140 are the same as the microstructure applicator 100 of the first embodiment.
  • the main body 210 includes an upper cover portion 212, a lower cover portion 114, and a body 116, and is the same as the main body 110 of the first embodiment except for the second through hole 212b.
  • the upper cover part 212 may further include a second through hole 212b at a position corresponding to the second button part 256 in addition to the first through hole 112a corresponding to the pressing part 152.
  • the button unit 250 may include a first button unit and a second button unit 256.
  • the first button unit is for pressing the liquid supply unit 130, and may include a pressing unit 152, a second plate 254, and a second elastic member 158.
  • the first button portion is the same as the button portion 150 of the first embodiment.
  • the second plate 254 may be formed with a third through hole 254a at a position corresponding to the first through hole 212b.
  • the second button unit 256 is for pressing the pressing member 120 and may be formed to extend from the first plate 124 toward the second plate 154. That is, the second button portion 256 may protrude outward through the second through hole 212b of the upper cover portion 212 and the third through hole 254a of the second plate 254.
  • the liquid supply portion 130 may be pressed by the second plate 154 to move vertically toward the lower cover portion 114 side.
  • the bottom surface of the receiving portion 132 is positioned equal to or lower than one end of the flow path portion 136. Therefore, by blocking the blocking portion 142 from the bottom surface of the receiving portion 132, the liquid second drug 20 may be discharged to the flow path portion 136 through the discharge port 134.
  • the liquid second drug 20 may be discharged through at least one second opening 114b communicating with the flow path portion 136. Therefore, the discharged liquid drug 20 'may be applied on the surface of the skin 1 through the flow path 114c.
  • the pressing portion 152 may be maintained until all of the liquid second drug 20 accommodated in the receiving portion 132 is discharged.
  • the first button unit may be maintained in a previous state.
  • the liquid supply unit 130 may be maintained as it is without moving downward.
  • a flange or plate supporting the second elastic member 158 may be further provided to maintain the compressed state of the second elastic member 158.
  • the pressing protrusion 122 vertically moves toward the lower cover portion 114, so that the microstructure 10 protrudes outward of the first opening 114a and the skin 1 ).
  • the microstructure and the liquid drug can be applied to the skin substantially simultaneously, the time difference between drug delivery by each can be reduced, and two types of drugs can be individually used as a single device. It can provide convenience.
  • the microstructure applicator 300 is for implanting the microstructure 10 into the skin 1 and then applying the liquid second drug 20 to the skin 1. .
  • the rate at which the liquid second drug 20 dissolves the microstructure 10 is fast, it may be applied on the surface of the skin 1 after implantation of the microstructure 10.
  • the button portion 350 is a first pressing step when pressed to a first depth, pressing the pressing member 320 so that the microstructure 10 is implanted into the skin 1, and when pressed to a second depth 2
  • the liquid supply unit 330 may be pressed so that the liquid second drug 20 is discharged to the surface of the skin 1.
  • the second depth may be greater than the first depth.
  • FIG. 12 is a cross-sectional view showing a microstructure applicator according to a third embodiment of the present invention
  • FIG. 13 is a cross-sectional view showing a state in which the button portion is pressed to a first depth in FIG. 12
  • FIG. 14 is a button portion in FIG. 12 It is a sectional view showing a state pressed to a second depth.
  • the microstructure applicator 300 includes a main body 310, a pressing member 320, a liquid supply unit 330, an opening / closing unit 340, and a button unit 350.
  • the body 310 may include an upper cover portion 312, a lower cover portion 314 and a body 316.
  • the main body 310 is the same as the main body 110 of the first embodiment, so a detailed description is omitted.
  • the pressing member 320 may include a pressing protrusion 322, a first plate 324, a first elastic member 326, a blocking portion 327, an extension portion 328 and a locking portion 329.
  • the pressing projection 322 and the first elastic member 326 are the same as the pressing projection 122 and the first elastic member 126 of the first embodiment, detailed description thereof will be omitted.
  • the pressing projection 322 may be formed shorter than the pressing projection 122 of the first embodiment because the vertical movement distance to the lower cover portion 314 is shorter than the pressing projection 122 of the first embodiment.
  • the first plate 324 is formed in a plate shape and may be disposed to be movable in the vertical direction within the body 316.
  • the first plate 324 may have a plurality of pressing protrusions 322 formed on one surface facing the lower cover portion 314.
  • the first plate 324 may have a groove portion 324a formed on one surface facing the second plate 354.
  • the groove portion 324a may be formed to a width corresponding to the width of the extension portion 328, and may be formed to a depth corresponding to a distance at which the liquid agent supply portion 330 vertically moves. That is, one end of the extension portion 328 may be inserted into the groove portion 324a during the second pressing of the button portion 350.
  • the blocking part 327 may protrude from the lower cover part 314 toward the first plate 324. At this time, the blocking portion 327 may be formed to be spaced apart from the first plate 324 by a predetermined interval. The blocking portion 327 may block the pressurization of the first plate 324. That is, the blocking unit 327 may block the first plate 324 from moving downward when the button 350 is pressed a second time.
  • the extension portion 328 may extend the first plate 324 and the second plate 354.
  • the extension portion 328 may be formed to extend from the second plate 354 toward the first plate 324. Accordingly, when the button portion 350 is pressed to the first depth, the first plate 324 may also be pressed together with the pressing of the second plate 354.
  • the locking portion 329 may be provided at one end of the first plate 324 in the extension portion 328.
  • the locking portion 329 supports one end of the extension portion 328 when the button portion 350 is pressed to a first depth. Accordingly, the extension part 328 may maintain a constant distance between the second plate 354 and the first plate 324.
  • the locking portion 329 may be inserted into the extension portion 328 by the support force of the first plate 324. That is, when the button portion 350 is pressed to the second depth, the first plate 324 is no longer moved downward by the blocking portion 327, and a supporting force is generated. Due to the support force generated as described above, the locking portion 329 may be inserted into the extension portion 328 and thus one side of the extension portion 328 may be inserted into the groove portion 324a. Accordingly, the distance between the first plate 324 and the second plate 354 can be reduced.
  • extension portion 328 is illustrated and described as being extended from the second plate 354 to the first plate 324 side, but is not limited thereto. That is, the extension part 328 may be formed to extend from the first plate 324 to the second plate 354. In this case, the groove portion 324a is formed on the side of the second plate 354, and the engaging portion 329 may be provided on the side of the second plate 354 in the extension portion 328.
  • the liquid supply part 330 may include a receiving part 332, a flow path part 336, and a second elastic member 338.
  • the liquid supply unit 330 is the same as the liquid supply unit 130 of the first embodiment except for the second elastic member 338, a detailed description thereof will be omitted.
  • the flow path unit 336 is longer than the flow path unit 136 in the first embodiment. Can be short.
  • the second elastic member 338 may be disposed between the receiving portion 332 and the lower cover portion 314.
  • the second elastic member 338 may restore the receiving portion 132 pressed by an external force to its original position.
  • the second elastic member 338 may be provided outside the flow path portion 336, but is not particularly limited thereto.
  • the opening / closing portion 340 may include a blocking portion 342 and a supporting portion 344.
  • the opening and closing portion 340 is the same as the opening and closing portion 140 of the first embodiment, a detailed description is omitted.
  • the support portion 344 may be shorter in length than the support portion 144 of the first embodiment.
  • the button part 350 may include a pressing part 352, a second plate 354, and a protruding part 356.
  • the button portion 350 is the same as the button portion 150 of the first embodiment except for the protruding portion 356, detailed description thereof will be omitted.
  • the protrusion 356 may be formed to protrude from the second plate 354 toward the liquid supply unit 330. At this time, the protrusion 356 may be formed to be spaced apart from the liquid supply unit 330 at a predetermined interval. Therefore, the external force is not transmitted to the liquid supply unit 330 until the protrusion 356 reaches the liquid supply unit 330. That is, the distance between the protrusion 356 and the liquid supply unit 330 may correspond to the first depth due to the first pressing of the pressing unit 352.
  • the first plate 324 when the button portion 350 is pressed to a first depth, the first plate 324 is pressed by the second plate 354 through the extension portion 328 to the lower cover portion 314 side. It can move vertically. At this time, the locking portion 329 may be supported on both sides of the groove portion 423 of the first plate 324. Therefore, the first plate 324 may be vertically moved while being pressed simultaneously with the second plate 354.
  • the pressing protrusion 322 vertically moves toward the lower cover portion 314, so that the microstructure 10 protrudes outward of the first opening 314a and the skin 1 Can be implanted in.
  • the protrusion 356 formed on the lower surface of the second plate 354 may reach the liquid supply unit 330. That is, before the protruding portion 356 reaches the receiving portion 332, the liquid supply unit 330 is not pressurized, and only the first plate 324 is pressed by the second plate 354, so that the microstructure 10 is It can be implanted first on the surface of the skin 1.
  • the lower surface of the first plate 324 may reach the blocking portion 327. That is, the first plate 324 is not pressed any more by the blocking portion 327 and can maintain its position.
  • the receiving portion 332 may move vertically toward the lower cover portion 314 as the liquid supply portion 330 is pressed. At this time, the bottom surface of the receiving portion 332 is positioned equal to or lower than one end of the flow path portion 336. Therefore, by blocking the blocking portion 342 from the bottom surface of the receiving portion 332, the liquid second drug 20 may be discharged to the flow path portion 336 through the discharge port 334.
  • the liquid second drug 20 may be discharged through at least one second opening 314b communicating with the flow path portion 336. Therefore, the discharged liquid drug 20 'may be applied on the surface of the skin 1 through the flow path 114c.
  • the button portion 350 may be maintained at a second depth until all of the liquid second drug 20 accommodated in the receiving portion 232 is discharged.
  • the drug which is difficult to manufacture with the microstructure, is applied in a liquid state together with the microstructure, the type of the delivery drug can be diversified.
  • the microstructure applicator of the present invention is provided with two button portions to independently press the liquid supply and the pressing member.
  • the microstructure applicator 400 according to the fourth embodiment of the present invention may include a first button portion and a second button portion 456.
  • the same components as the third embodiment use the same reference numerals, and detailed description thereof will be omitted.
  • FIG. 15 is a cross-sectional view showing a microstructure applicator according to a fourth embodiment of the present invention
  • FIG. 16 is a cross-sectional view showing a state in which the first button portion is pressed in FIG. 15
  • FIG. 17 is a second button portion in FIG. 15 It is a sectional view showing a pressed state.
  • the microstructure applicator 400 may include a main body 410, a pressing member 420, a liquid supply unit 330, an opening / closing unit 340, and a button unit 450.
  • the liquid supply unit 330 and the opening / closing unit 340 are the same as the microstructure applicator 300 of the third embodiment.
  • the body 410 includes an upper cover portion 412, a lower cover portion 314, and a body 316, and is the same as the body 310 of the third embodiment except for the second through hole 412b.
  • the upper cover part 412 may further include a second through hole 412b at a position corresponding to the second button part 456 in addition to the first through hole 312a corresponding to the pressing part 452.
  • the pressing member 420 is the same as the pressing member 320 of the third embodiment except for the first plate 424 and the extension 428.
  • the groove portion 324a is not formed in comparison with the first plate 324 of the third embodiment, and the extension portion 428 may be connected. That is, the extension portion 428 may be coupled to both sides of the first plate 424 and the second plate 454.
  • the button part 450 may include a first button part and a second button part 456.
  • the first button portion is for pressing the pressing member 420, and may include a pressing portion 352, a second plate 454, and a second elastic member 358.
  • the first button portion is the same as the button portion 350 of the third embodiment except for the third through hole 454a and the protruding portion 356.
  • the second plate 454 may be formed with a third through hole 454a at a position corresponding to the first through hole 312b.
  • the second button unit 456 is for pressing the liquid supply unit 330 and may be formed to extend from the liquid supply unit 330 toward the second plate 454. That is, the second button portion 456 may protrude outward through the second through hole 412b of the upper cover portion 412 and the third through hole 454a of the second plate 454.
  • the first plate 424 is pressed by the second plate 454 through the extension portion 428 to the lower cover portion 314 side. It can move vertically.
  • the pressing projection 322 may move vertically toward the lower cover portion 314. Therefore, the microstructure 10 may protrude outward of the first opening 314a and be implanted in the skin 1.
  • the liquid supply unit 330 is pressed and moves vertically toward the lower lid unit 314. You can.
  • the first button portion may be maintained in a previous state.
  • the bottom surface of the receiving portion 332 is positioned equal to or lower than one end of the flow path portion 336. Therefore, by blocking the blocking portion 342 from the bottom surface of the receiving portion 332, the liquid second drug 20 may be discharged to the flow path portion 336 through the discharge port 334.
  • the liquid second drug 20 may be discharged through at least one second opening 314b communicating with the flow path portion 336. Therefore, the discharged liquid drug 20 'may be applied on the surface of the skin 1 through the flow path 314c.
  • the microstructure and the liquid drug can be applied to the skin substantially simultaneously, the time difference between drug delivery by each can be reduced, and two types of drugs can be individually used as a single device. It can provide convenience.
  • the first to fourth embodiments of the present invention is a form of shooting a microstructure using an elastic force, which may cause pain in the skin by the shooting force. Therefore, a method of reducing pain when inserting a microstructure into the skin is required.
  • the microstructure applicator 500 according to the fifth embodiment of the present invention can implant the microstructure into the skin by an external force by the user.
  • FIG. 18 is a perspective view of a microstructure applicator according to a fifth embodiment of the present invention
  • FIG. 19 is an exploded perspective view of FIG. 18.
  • the microstructure applicator 500 includes a liquid supply unit 510, a body 520, and a microstructure module 530.
  • the microstructure applicator 500 is for implanting the microstructure of the microstructure module 530 into the skin by an external force by the user.
  • the "external force” is a pressing force by the user, and may be a force that presses the microstructure applicator 500 in the direction of the skin.
  • the external force may be an external force by a mechanical device.
  • the user's pain can be reduced compared to the first to fourth embodiments or the conventional shooting device, thereby improving user convenience.
  • the microstructure may include a first drug.
  • the microstructure applicator 500 supplies the second drug 516 for promoting the action of the microstructure through the liquid supply unit 510.
  • the action of the microstructure refers to a series of processes in which the microstructure penetrates the skin, dissolves, and diffuses and absorbs in the skin.
  • the second drug 516 may be a liquid drug applied to the skin.
  • the present invention is not limited thereto, and the second drug 516 may not include a specific drug and may include only a solvent.
  • the liquid second drug 516 may include at least one of minoxidil, triamcinolone and finasteride.
  • the liquid second drug 516 is applied on the skin after the microstructure is implanted into the skin to promote at least one of skin penetration, dissolution, diffusion in the skin, and absorption into the skin.
  • microstructure helps the action of the microstructure after being inserted into the skin, it is possible to improve the efficacy of drug delivery contained in the microstructure.
  • the liquid supply unit 510 is provided on the upper side of the main body 520 and supplies the second liquid 516 in the liquid state to the microstructure module 530 side. At this time, the liquid supply unit 510 may be detachably provided on the main body 520. That is, the liquid supply unit 510 may be provided separately from the main body 520. Alternatively, the liquid supply unit 510 may be integrally provided with the main body 520.
  • the main body 520 is a microstructure module 530 is coupled to the lower side to insert the microstructure into the skin to the external force by the user.
  • the main body 520 may be a portion that the user grasps and exerts a force.
  • the main body 520 may transfer the liquid second drug 516 supplied from the liquid supply unit 510 to the microstructure module 530 side.
  • the microstructure module 530 is provided with a microstructure including the first drug.
  • the microstructure module 530 may be a portion that is in close contact with the user's skin.
  • the micro-structure module 530 may flow to apply the liquid second drug 516 supplied from the liquid supply unit 510 through the main body 520 on the skin.
  • the liquid supply unit 510 may include a receiving unit 512 and a drawing unit 514.
  • the receiving part 512 may accommodate the second drug 516 in a liquid state.
  • the accommodation unit 512 may have a constant accommodation space.
  • the receiving portion 512 may be formed in an oval shape. At this time, the receiving portion 512 may flow the liquid second drug 516 into the withdrawal portion 514 in a dropper manner.
  • the receiving portion 512 may be provided to protrude at least a portion of the body 520 to the outside. That is, the user presses the receiving portion 512 using the protruding portion of the receiving portion 512, so that the liquid second drug 516 accommodated in the receiving portion 512 flows through the drawing portion 514. You can.
  • the liquid second drug 516 may be supplied in full quantity at a time or divided into several times. For example, when the liquid second drug 516 is supplied in a divided manner, it may be repeatedly supplied at regular time intervals. That is, by the eyedropper method, the receiving part 512 may supply the second drug 516 in a liquid state at a predetermined parallax interval.
  • the working effect of the microstructure can be improved by supplying the liquid second drug 516 at regular intervals according to the action steps of the microstructure inserted into the skin.
  • the receiving unit 512 may be configured to be sealed when the liquid supply unit 510 is configured separately from the main body 520, that is, when the liquid supply unit 510 is replaceable.
  • the receiving unit 512 may include an injection port for injecting the second drug 516 in the liquid phase.
  • the lead-out portion 514 may be formed to extend from the lower side of the receiving portion 512. At this time, the withdrawal part 514 may flow the liquid second drug 516 through the main body 520.
  • the receiving portion 512 and the drawing portion 514 may be integrally formed.
  • the liquid supply unit 510 may be made of a soft material to supply the liquid second drug 516 in a dropper method.
  • the liquid supply unit 510 may be made of polyethylene material.
  • FIG. 20 is a cross-sectional view of the body of FIG. 18, and FIG. 21 is a perspective view of the body of FIG. 18.
  • the body 520 may include a handle part 521, an extension part 522, and a support part 523.
  • the main body 520 may be approximately stamped. That is, the main body 520 has a handle portion 521 formed convexly, an extension portion 522 formed concavely, and a support plate 531 may be formed flat from the extension portion 522.
  • the handle part 521 is a part for a user to grasp.
  • the handle portion 521 may be provided with a seating portion 525 for mounting the liquid supply portion 510 therein.
  • the seating portion 525 may have a shape corresponding to the shape of the liquid supply unit 510.
  • the handle portion 521 may be formed in a cylindrical shape so that the user is easy to hold and the liquid supply portion 510 is mounted.
  • the seating portion 525 may be provided with a projection 526 at regular intervals on the inner wall surface.
  • the protrusion 526 may be in close contact with the receiving portion 512 of the liquid supply unit 510.
  • a certain space may be formed between the protrusion 526 and the protrusion 526.
  • the deformed portion is accommodated between the protruding portions 526, so that the protruding portion 526 is a receiving portion in the process in which the receiving portion 512 operates in an eyedropper manner. It can be assisted to maintain the shape of (512).
  • the contact area between the inside of the seating portion 525 and the receiving portion 512 is reduced, and The frictional force between the inner surface of the portion 525 and the outer surface of the receiving portion 512 is reduced to induce the receiving portion 512 to be smoothly mounted on the seating portion 525.
  • the extension part 522 may be formed to extend from the handle part 521 to the support part 523.
  • the extension portion 522 may be formed to be concave compared to the handle portion 521. That is, the diameter of the extension portion 522 may be smaller than the diameter of the handle portion 521.
  • the support 523 may be formed in a plate shape perpendicular to the extension 522.
  • the support portion 523 may be a portion to which the microstructure module 530 is coupled.
  • the support part 523 may be formed radially from the extension part 522. That is, the extension part 522 may be disposed at the center of the support part 523.
  • the support 523 may be formed in a shape corresponding to the planar shape of the microstructure module 530.
  • the support portion 523 may be formed with a coupling portion 524 to which the micro-structure module 530 is coupled to the lower side protruding.
  • the coupling portion 524 may be disposed at the center of the support portion 523.
  • the coupling portion 524 may be formed in a circular shape.
  • the outer diameter of the coupling portion 524 may be substantially the same as the inner diameter of the through hole 534 of the microstructure module 530.
  • the microstructure module 530 may be coupled to the main body 520 in a forced fit manner.
  • the flow path portions 527 and 528 may be formed to extend from the seating portion 525 to the coupling portion 524.
  • the flow path portions 527 and 528 are passages for flowing the liquid second drug 516. That is, the flow path portions 527 and 528 may be formed from the bottom surface of the seating portion 525 to the coupling portion 524.
  • the flow path parts 527 and 528 may be formed in various shapes inside the body 520.
  • the flow path portions 527 and 528 are illustrated and described as being vertically formed, but are not limited thereto.
  • the flow path portions 527 and 528 may be formed in a zigzag, straight or curved shape in the horizontal direction inside the main body 520.
  • the flow path portion 528 may function as a guide. That is, a part of the withdrawal portion 514 may be inserted into the flow path portion 528.
  • a stepped portion may be provided at the boundary between the flow path portion 527 and the flow path portion 528. That is, the diameter of the flow path portion 527 may be smaller than the diameter of the flow path portion 528. Therefore, the end of the withdrawal portion 514 may be supported on the stepped portion.
  • FIG. 22 is a cross-sectional view of an example of the microstructure module of FIG. 18.
  • the microstructure module 530 may include a support plate 531, microscopic protrusions 532 and a microstructure 533.
  • the microstructure module 530 may be integrally formed with the microstructure 533.
  • the microstructure module 530 may be formed for a single use.
  • the support plate 531 may be formed in a plate shape corresponding to the support portion 523 of the main body 520.
  • the support plate 531 may be formed with a through hole 534 in the center thereof.
  • the present invention is not limited thereto, and the through hole 534 may be formed at a different position on the support plate 531.
  • the through-hole 534 is for coupling to the coupling portion 524 of the body 520, it may have a shape corresponding to the coupling portion (524).
  • the through hole 534 may have a circular shape.
  • the fine protrusions 532 may be protruded at regular intervals from the lower side of the support plate 531.
  • between the fine protrusions 532 and the fine protrusions 532 may function as a first flow path 535 through which the liquid second drug 516 flows. That is, in the state in which the microstructure 533 is inserted into the skin, the fine protrusions 532 may form a first flow path 535 between the skin and the support plate 531.
  • liquid second drug 516 flowing from the main body 520 flows out through the first flow passage 535 formed by the fine protrusions 532 and flows through the first passage 535 formed by the fine protrusions 532. Can be applied.
  • the microstructure 533 may be formed on the fine protrusion 532. At this time, the microstructure 533 may be formed by spotting after applying a viscous composition to the fine protrusions 532.
  • the viscous composition may be formed by a biocompatible or biodegradable material as described above, or a drug that can be injected into the body and combinations thereof.
  • the microstructure 533 may include a first drug.
  • the first drug may be integrally formed with the microstructure 533.
  • the microstructure 533 may have a horizontal cross-section.
  • the micro-structure 533 may be formed in a circular shape having a constant area in the area to be joined to the micro-projection (532).
  • the microstructure 533 may include a pointed tip having a pointed shape on a portion implanted into the skin.
  • the microstructure 533 can be administered to the skin to a certain depth as soon as the first drug loaded therein is implanted into the skin.
  • FIG. 23 is a cross-sectional view of another example of the microstructure module of FIG. 18.
  • the microstructure module 530 ′ may be provided with an additional flow path on the support plate 531. That is, the microstructure module 530 'may further include a second flow path 536 and a third flow path 537.
  • the second flow passage 536 may be provided on the support plate 531 to be orthogonal to the through hole 534. That is, the second flow path 536 may be formed horizontally on the support plate 531 in the direction in which the fine protrusions 532 are formed.
  • the third flow path 537 may be formed on the support plate 531 such that the first flow path 535 and the second flow path 536 communicate. That is, the third flow path 537 may be formed vertically in the support plate 531 to communicate with the space between the fine protrusions 532.
  • liquid second drug 516 flowing into the through-hole 534 can flow more smoothly within the support plate 531. Therefore, the liquid second drug 516 may be more uniformly applied to the skin.
  • FIG. 24 is a cross-sectional view showing a state in which the microstructure is inserted into the skin by the microstructure applicator according to the fifth embodiment of the present invention, and FIG. 25 shows the state in which the second drug is applied to the skin after FIG. 24 It is a cross section.
  • the microstructure 533 is in the skin 1 by the microprotrusion 532. Is inserted.
  • a first flow path 535 between the microscopic projections 532 may be formed between the support plate 531 and the skin 1.
  • the liquid second drug 516 passes through the withdrawal portion 514 and the flow path portion 527 to finally pass through ( 534) can be applied to the skin (1).
  • liquid second drug 516 may be flowed through the first flow path 535 between the fine protrusions 532 so that the microstructure 533 is spread over the entire portion of the inserted skin 1. .
  • liquid second drug 516 is applied on the skin 1 after the microstructure 533 is transplanted to the skin 1, and the skin penetrates, dissolves, diffuses into the skin and spreads into the skin. It can promote at least one of the absorption.
  • the liquid second drug 516 may be supplied in full quantity at one time or divided into several times. For example, when the liquid second drug 516 is supplied in a divided manner, it may be repeatedly supplied at regular time intervals. That is, by the eyedropper method, the receiving part 512 may supply the second drug 516 in a liquid state at a predetermined parallax interval.

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention concerne un applicateur de microstructure. Un applicateur de microstructure selon un mode de réalisation de la présente invention comprend : un corps principal ; une microstructure intégrée dans le corps principal ou accouplée au côté inférieur du corps principal, et contenant un premier médicament ; et une unité d'alimentation en liquide, disposée dans le corps principal, permettant d'alimenter la phase liquide en un second médicament. Dans la présente invention, le second médicament dans la phase liquide est appliqué sur la surface de la peau avant ou après l'implantation de la microstructure dans la peau.
PCT/KR2019/013074 2018-10-08 2019-10-04 Applicateur de microstructure WO2020076018A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2018-0119648 2018-10-08
KR1020180119648A KR102215571B1 (ko) 2018-10-08 2018-10-08 마이크로 구조체 슈팅 디바이스
KR10-2019-0116617 2019-09-23
KR1020190116617A KR102174568B1 (ko) 2019-09-23 2019-09-23 스탬프형 마이크로구조체 어플리케이터

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WO2020076018A1 true WO2020076018A1 (fr) 2020-04-16

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PCT/KR2019/013074 WO2020076018A1 (fr) 2018-10-08 2019-10-04 Applicateur de microstructure

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WO (1) WO2020076018A1 (fr)

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CN114748778A (zh) * 2021-01-11 2022-07-15 苏州纳生微电子有限公司 传动结构、应用传动结构的给液装置及其使用方法

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KR20100064669A (ko) * 2008-12-05 2010-06-15 폴 곽 마이크로 니들 피부 미용기
KR20110098398A (ko) * 2010-02-26 2011-09-01 주식회사 유니온 메디칼 주입식 마이크로니들 스탬프
KR20140012336A (ko) * 2012-07-19 2014-02-03 (주)아모레퍼시픽 노즐 장치 및 이를 포함하는 최소 침습형 주입 장치
KR101608179B1 (ko) * 2015-11-24 2016-03-31 지승구 피부용 약물주입장치
JP2017185162A (ja) * 2016-03-31 2017-10-12 コスメディ製薬株式会社 マイクロニードルアプリケータ

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Publication number Priority date Publication date Assignee Title
KR20100064669A (ko) * 2008-12-05 2010-06-15 폴 곽 마이크로 니들 피부 미용기
KR20110098398A (ko) * 2010-02-26 2011-09-01 주식회사 유니온 메디칼 주입식 마이크로니들 스탬프
KR20140012336A (ko) * 2012-07-19 2014-02-03 (주)아모레퍼시픽 노즐 장치 및 이를 포함하는 최소 침습형 주입 장치
KR101608179B1 (ko) * 2015-11-24 2016-03-31 지승구 피부용 약물주입장치
JP2017185162A (ja) * 2016-03-31 2017-10-12 コスメディ製薬株式会社 マイクロニードルアプリケータ

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114748778A (zh) * 2021-01-11 2022-07-15 苏州纳生微电子有限公司 传动结构、应用传动结构的给液装置及其使用方法
CN114748778B (zh) * 2021-01-11 2024-05-03 苏州纳生微电子有限公司 传动结构、应用传动结构的给液装置及其使用方法

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