WO2020058555A1 - Écran d'absorption de rayonnement diffus - Google Patents

Écran d'absorption de rayonnement diffus Download PDF

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Publication number
WO2020058555A1
WO2020058555A1 PCT/ES2019/070628 ES2019070628W WO2020058555A1 WO 2020058555 A1 WO2020058555 A1 WO 2020058555A1 ES 2019070628 W ES2019070628 W ES 2019070628W WO 2020058555 A1 WO2020058555 A1 WO 2020058555A1
Authority
WO
WIPO (PCT)
Prior art keywords
shield
radiation
semi
shield according
lead
Prior art date
Application number
PCT/ES2019/070628
Other languages
English (en)
Spanish (es)
Inventor
Francisco Manuel Cañete Sánchez
Xavier Louis Etienne Boulvard
Pablo Javier Marrodán Lafuente
Xabier Chamorro Sánchez
Original Assignee
Fundación Rioja Salud
Mondragon Goi Eskola Politeknikoa J. M. Arizmendiarreta S.Coop.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundación Rioja Salud, Mondragon Goi Eskola Politeknikoa J. M. Arizmendiarreta S.Coop. filed Critical Fundación Rioja Salud
Publication of WO2020058555A1 publication Critical patent/WO2020058555A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/16—Measuring radiation intensity
    • G01T1/161—Applications in the field of nuclear medicine, e.g. in vivo counting
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
    • G21F1/00—Shielding characterised by the composition of the materials
    • G21F1/12—Laminated shielding materials
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
    • G21F3/00—Shielding characterised by its physical form, e.g. granules, or shape of the material

Definitions

  • the present invention relates to a scattered radiation absorption shield usable in nuclear medicine. It is especially applicable in lymphoscintigraphy for the identification and biopsy of the sentinel node in breast cancer. However, it can also be used for lymphoscintigraphy in the study of other oncological diseases such as skin cancer, head and neck cancer, etc.
  • Sentinel nodes are the regional lymph nodes that receive lymph directly from the primary tumor, making sentinel nodes the first nodules to receive metastatic cells. Accurate lymph node staging is essential for the prognosis and treatment of different cancer patients.
  • Lymphogammagraphy is an image that allows the visualization of this process, facilitating the location and approach of the sentinel node to the surgeon, allowing the nodes to be observed before the surgical act.
  • This technique is performed by injecting a tracer into the tumor or peritumoral that migrates through the lymphatic routes to the sentinel nodes.
  • the injection site emits a large amount of radiation that makes it difficult to detect the sentinel node to be studied.
  • a lead sheet is used between the injection point (emitter) and the detector (receiver, which receives the signal, translates it and forms the image).
  • This sheet is generally designed in the Radiation Oncology Services using a mold cutter, obtaining a flat and circular lead sheet (coin shape).
  • the invention solves this problem, allowing fast and quality image taking.
  • the invention consists of a shield according to the claims.
  • This scattered radiation absorption shield comprises at least one layer of radiation-absorbing material and, novelty, is bowl-shaped, with the concave side configured for the placement of part of the patient's body inside, the source or origin of radiation being on that side, inside the shield.
  • the shield of the invention we can introduce the injection point in the concavity of the shield, reducing scattered radiation by more than 85% in patients with breast cancer, thus facilitating detection of the sentinel node and decreasing the image acquisition time (there is hardly any replacement of the shield). Therefore, the test duration is reduced and the image quality increases.
  • a preferred embodiment has a radial "hat-brim” rim.
  • the specific shape of the bowl is variable, but the most suitable shapes are considered to be hemispherical and semi-ellipsoidal.
  • Figure 1 Shows two images of an embodiment with the hemispherical shield, in perspective view and cross section.
  • Figure 2 Shows a cross section of a second embodiment with the semi-ellipsoidal shield.
  • Figure 4 Scheme showing the moment in which the scan is performed, using a curved shield according to the present invention.
  • Figure 5 Examples of scintigraphy with a flat shield (above), with a curved shield in the shape of a semi-ellipsoidal bowl (bottom left) and with a curved shield in the shape of a hemispherical bowl (bottom right).
  • Figures 1 and 2 show two exemplary embodiments of the shield (1) of the invention, formed by two bow-shaped bowls.
  • the first example corresponds to a section circular, while the second corresponds to an elliptical section.
  • they will be sectors of a sphere or an ellipsoid, generally being hemispheres or semi-ellipsoids. They can be egg-shaped, oval in section.
  • the shield (1) is configured so that its concave part is oriented towards the patient, so that it can cover a larger area around the injection point (5), the origin of the radiation, in the patient ( Figure 4).
  • the shield (1) is formed by at least one layer of radiation absorbing material, such as lead, tin, bismuth, tungsten, antimony, polyethylene, water, etc., preferably lead.
  • radiation absorbing material such as lead, tin, bismuth, tungsten, antimony, polyethylene, water, etc., preferably lead.
  • Shields (1) can be generated by molding, as explained below.
  • a polymer standard (reference standard) was generated using a 3D printer, such as that sold as SICNOVA JCR 1000 3D.
  • Reference standards can for example be designed using a computer aided design (CAD) program.
  • the mold preferably of sand, is manufactured in accordance with the corresponding reference standard.
  • the mold is filled with a radiation absorbing material, preferably lead, in the molten state. Once this material solidifies, the mold is removed, and then the shield (1) is polished and painted, for example with white acrylic water-based primer paint for surfaces that are difficult to adhere to, and then with 100% acrylic traffic paint. water based.
  • shields (1) can be generated by other manufacturing processes such as injection molding, compression molding, manual lamination molding, vacuum molding, etc., from solid materials, powder, fabric, etc.
  • the shield (1) of the invention will preferably have completely rounded edges. This prevents the edges in theory from acting as antennas, attracting and deflecting the radiation, which could increase the scattering of the radiation and reduce the quality of the image.
  • the radius of each edge can be between 3 and 5 mm.
  • the shield (1) can have a radial flange (2) (like a hat brim). It is independent of the concrete shape of the shield (1).
  • Figure 3 shows the patient lying supine on the stretcher, and we see how with the flat shield of the state of the art, the radiation reaches the detector (6), producing scatter (3) in the scan represented in the upper part of the figure. In the left axillary region, the sentinel node (4) that is close to the scatter (3) is observed.
  • Figure 4 shows the curved shield (1) of the invention arranged around the injection point (5), which prevents radiation from escaping and cancels the scatter, only the image of the sentinel node (4) being observed in the scan, represented again at the top of the figure. It can be seen how the detector cannot receive the radiation from the injection point (5).
  • Figure 5 shows three examples of scans.
  • the upper scan shows a large stain of scattered radiation, despite having a flat shield.
  • the other two correspond to curved shields according to the invention, the lower left scan using the semi-ellipsoid shield and the lower right scan using the hemispherical shield.
  • Example 1
  • Two pure lead alloy shields were made, one semi-ellipsoidal and one semi-spherical. Lymphoscintigraphy was performed on 20 patients with breast cancer after an intratumoral or periareolar injection of 111 MBq of 99mTc-nacoloid albumin. Early images (5 minutes post-injection) and late images (120 minutes post-injection) were performed in anterior and anterior oblique projections, obtaining 2-minute images with each shield, obtaining a total of 225 valid images.
  • Absolute counts and normalized background subtraction were calculated, as well as the percentage of scattered radiation reduction of the hemispherical and semi-ellipsoidal shields in relation to the use of a flat lead shield, both in early studies and in late studies. Likewise, the need to reposition the shield at each projection and with each shield was estimated.

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine (AREA)

Abstract

L'invention concerne un écran (1) d'absorption de rayonnement diffus, caractérisé en ce qu'il comprend au moins une couche de matériau absorbant le rayonnement, et possède une forme de bol, le côté concave étant conçu pour le placement d'une partie du corps du patient à l'intérieur, et la source du rayonnement étant dudit côté.
PCT/ES2019/070628 2018-09-20 2019-09-20 Écran d'absorption de rayonnement diffus WO2020058555A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES201831420U ES1219895Y (es) 2018-09-20 2018-09-20 Escudo de absorción de radiación dispersa
ESU201831420 2018-09-20

Publications (1)

Publication Number Publication Date
WO2020058555A1 true WO2020058555A1 (fr) 2020-03-26

Family

ID=63915408

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2019/070628 WO2020058555A1 (fr) 2018-09-20 2019-09-20 Écran d'absorption de rayonnement diffus

Country Status (2)

Country Link
ES (1) ES1219895Y (fr)
WO (1) WO2020058555A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003255080A (ja) * 2002-02-28 2003-09-10 Nihon Medi Physics Co Ltd 放射線遮蔽体
US6703632B1 (en) * 1999-06-01 2004-03-09 The Cleveland Clinic Foundation Radiation shield
BE1016343A3 (nl) * 2004-12-09 2006-08-01 Janssens Jacques Phillibert Beschermingselement om delen van het lichaam te beschermen tegen schadelijke stralen.
WO2007038238A2 (fr) * 2005-09-22 2007-04-05 Xoft, Inc. Écran léger d’absorption de radiations
US20080027266A1 (en) * 2002-09-10 2008-01-31 Cianna Medical, Inc. Brachytherapy apparatus and methods for using same
US20140048729A1 (en) * 2011-10-04 2014-02-20 Surikat S.A Radiation protection device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6703632B1 (en) * 1999-06-01 2004-03-09 The Cleveland Clinic Foundation Radiation shield
JP2003255080A (ja) * 2002-02-28 2003-09-10 Nihon Medi Physics Co Ltd 放射線遮蔽体
US20080027266A1 (en) * 2002-09-10 2008-01-31 Cianna Medical, Inc. Brachytherapy apparatus and methods for using same
BE1016343A3 (nl) * 2004-12-09 2006-08-01 Janssens Jacques Phillibert Beschermingselement om delen van het lichaam te beschermen tegen schadelijke stralen.
WO2007038238A2 (fr) * 2005-09-22 2007-04-05 Xoft, Inc. Écran léger d’absorption de radiations
US20140048729A1 (en) * 2011-10-04 2014-02-20 Surikat S.A Radiation protection device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 808418, Derwent World Patents Index; AN 2003-808418 *

Also Published As

Publication number Publication date
ES1219895U (es) 2018-10-31
ES1219895Y (es) 2019-01-21

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