WO2020049584A1 - Formulation de granulés mouillables pesticides synergique comprenant du benzoate d'émamectine et du profénofos - Google Patents

Formulation de granulés mouillables pesticides synergique comprenant du benzoate d'émamectine et du profénofos Download PDF

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WO2020049584A1
WO2020049584A1 PCT/IN2019/050269 IN2019050269W WO2020049584A1 WO 2020049584 A1 WO2020049584 A1 WO 2020049584A1 IN 2019050269 W IN2019050269 W IN 2019050269W WO 2020049584 A1 WO2020049584 A1 WO 2020049584A1
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formulation
synergistic
stable
present
profenofos
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PCT/IN2019/050269
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English (en)
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Keshav ANAND
Uday ANAND
Sarvind DHIMAN
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Parijat Industries (India) Private Limited
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Publication of WO2020049584A1 publication Critical patent/WO2020049584A1/fr

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/12—Powders or granules
    • A01N25/14—Powders or granules wettable
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system

Definitions

  • Embodiments of the present invention generally relate to the field of pesticidal formulations, and, more particularly, to a synergistic and stable pesticidal granular formulation.
  • pesticides are substances meant to control pests or weeds.
  • the Food and Agriculture Organization has defined a pesticide as,“any substance or mixture of substances intended for preventing, destroying, or controlling any pest, including vectors of human or animal disease, unwanted species of plants or animals, causing harm during or otherwise interfering with the production, processing, storage, transport, or marketing of food, agricultural commodities, wood and wood products or animal feedstuffs, or substances that may be administered to animals for the control of insects, arachnids, or other pests in or on their bodies”.
  • the term further includes substances intended for use as a plant growth regulator, defoliant, desiccant, or agent for thinning fruit or preventing the premature fall of fruit.
  • Pesticides are also used as substances that are applied to crops either before or after harvest to protect the commodity from deterioration during storage and transport.
  • Emamectin benzoate is widely used in the United States of America and Canada as an insecticide because of its chloride channel activation properties.
  • Emamectin benzoate works as a chloride channel activator by binding gamma amino butyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods.
  • GABA gamma amino butyric acid
  • the compound stimulates the release of GABA from the synapses between nerve cells and while additionally increasing GABA’s affinity for its receptor on the post-junction membrane of muscle cells in insects and arthropods.
  • the stronger binding of GABA increases the cells permeability to chloride ions within the cell due to the hypotonic concentration gradient. Neurotransmission is thereby reduced by subsequent hyperpolarization and the elimination of signal transduction.
  • Profenofos can be used on a variety of crops including cotton and vegetables such as maize, potato, soybean, and sugar beet. In the United States, it is used exclusively on cotton and is primarily
  • Profenofos is available in market as emulsifiable concentrate (EC) formulation and ultra-low volume liquid (UL) formulation. Profenofos is also available in mixture with cypermethrin, beta-cypermethrin, phoxim, imidacloprid and deltamethrin. Profenofos is a non-systemic insecticide. Profenofos can be used against cotton mealybug, cabbage caterpillar, plutella xylostella and asparagus caterpillars, as well as against wheat and cabbage aphids.
  • Profenofos mechanism of action is via the inhibition of the acetyl cholinesterase enzyme.
  • the S (-) isomer is a more potent inhibitor.
  • an active substance when an active substance is in a liquid state at ambient temperatures, then it has been formulated in a number of ways that to varying extents, so that formulated products are adapted for ease of transport, handling and application. It is generally desirable with these various formulations that the active substance be delivered in the form of an aqueous spray. Examples of types of formulations that may be applied in this manner are emulsifiable concentrates (EC), suspension concentrates (SC) and oil dispersion (OD) etc. Limitations of EC and OD formulations include the dangers in packaging, storing and handling highly flammable solvents. SC formulations can have storage problems and are difficult to clean up after spillage.
  • Wettable granule (WG) or Water dispersible granule (WDG) formulations offer significant advantages in packaging, ease of handling and safety.
  • these consist of small granules and preferably of uniform size and which are free flowing, low dusting and readily disperse in water to form homogenous suspension of very small particles that may pass through conventional spray nozzles.
  • wettable granule or water dispersible granule formulations when dispersed in water under gentle agitation for few minutes have residues of less than 0.01 % on a 150 pm sieve screen and less than 0.5% on a 53 pm screen.
  • the granules can usually be measured accurately by volume which is convenient for the end user.
  • this prior art is claiming specifically azamethiphos, cypermethrin high-cis and fenoxycarb in combination with Emamectin benzoate. Therefore, this prior art is not specifically for Profenofos in combination with Emamectin benzoate. Also, liquid active ingredient like Profenofos in the synergistic, stable and safe wettable granule formulation of the instant invention is present in higher amount in comparison to this prior art. Even due to presence of higher amount of liquid active ingredient like Profenofos, the granules of present invention are dustless and free flow with other advanced quality of formulation, which is a technically advanced step in comparison to this prior art.
  • US patent application US 2006/0093637 A1 discloses an insecticidal composition comprising insecticide and phosphonates or derivatives thereof.
  • Australian Patent Application No. AU 2007230693 B2 discloses a dry spreadable
  • At least one substantially water-insoluble active chemical agent at least one substantially water-insoluble active chemical agent; and iii) an emulsifier system capable of forming a microemulsion of the at least one substantially water-insoluble active chemical agent (ii) upon dilution in water.
  • Chinese Patent Application No. CN 102047905A discloses emulsion in water (EW) formulation having the mass percent of the Emamectin benzoate to the Profenofos is (0.1-20): (5-80).
  • EW emulsion in water
  • the present invention has advantages over this prior art in the form of efficacy, stability and safety by wettable granule formulation comprising liquid active ingredient Profenofos and Emamectin benzoate.
  • Chinese Patent Application No. CN 101601406 A discloses about water dispersible granule formulation comprising Pymetrozine and Profenofos, wherein in preferred examples maximum amount of Profenofos used is 25%, further this composition is used to control rice planthopper.
  • the drawback of this prior art is that it is not used in broad spectrum against pest and in various crops.
  • Indian Patent Application No. IN 705/DEL/2013 discloses an insecticidal composition of Emamectin benzoate amount ranging from 0.5 to 3% by weight and thiamethoxam amount ranging from 10-15% by weight of the composition, here both active ingredients are in solid form, thus it is easy to prepare granular formulation of solid active ingredients, rather this document is not specifically describing synergistic and stable wettable granule formulation comprising Emamectin benzoate and Profenofos, having water content less than 3.0%. Also, one of the active ingredient Profenofos, of present invention is in liquid form, thus it is a technically advance step to prepare its granular formulation having its broader synergistic amount in comparison to prior art.
  • Indian Patent IN 263280 discloses the process for the preparation of water dispersible granular formulation where suspension concentrate or dispersion of solid active ingredient was done which then be granulated. Further on this granule, the emulsifiable solution of liquid active ingredient is absorbed i.e. sprayed. This whole process is lengthy and also even spraying of emulsifiable solution of liquid active ingredient is not environmentally friendly.
  • the formulation of this document had two agrochemically acceptable excipients, whereas present invention is specifically for synergistic and stable wettable granule formulation comprising Emamectin benzoate and Profenofos. Even also the process for the preparation of present invention formulation is economical and commercially viable.
  • PCT Patent Application No. WO/2017/180658 A1 discloses EC formulations (emulsifiable concentrate) comprising 10-40% by weight of one or more actives among the organophosphates. Profenofos is not disclosed in the specification of this document. Further, due to use of organic solvent EC formulation causes environmental pollution and phytotoxicity to plants. Accordingly, there exists a need in the art for developing a suitable wettable granule composition comprising two or more active ingredients, because the use of instant granular formulation is less risky for farmers then the corresponding liquid formulation, as the exposure to hazardous chemicals gets reduced. However, the solid pesticidal composition such as wettable granule (WDG or WG) containing combination of agriculture actives with different mode of action can be difficult to produce.
  • WDG or WG wettable granule
  • solid formulation such as wettable granule typically requires the active ingredients to be in the form of appropriate dispersed particle in order to achieve optimal suspensibility in water.
  • direct grinding of the discrete solid of that active ingredient can be difficult due to melting or softening of the active ingredient itself during grinding when subject to range of temperature and shear stress which is normally encountered during processing and storage.
  • the storage stability of granule formulation containing low melting active ingredient or liquid active ingredient in the form of solid particles can be negatively impacted by the tendency of the solid particles to soften and then coalesce or agglomerate into large particles.
  • Such physical instability can lead to granule formulation that does not disperse well in water and forms unstable suspension that delivers substandard biological efficacy due to poor delivery on target locus of the pests after application.
  • Multiple embodiments of the present invention relate to a synergistic and stable pesticidal wettable granule formulation having excellent insecticidal property comprising an effective amount of Emamectin benzoate and Profenofos as active ingredients.
  • the present invention also relates to process for preparing the said stable granular formulation comprising an Emamectin benzoate, 1 to 3% by weight of formulation and Profenofos, 32% to 40% by weight of formulation.
  • Yet another aspect of the present invention is to make a safe, free flowing, dustless dispersible granular formulation along with inactive excipients.
  • the present invention also related to process for preparing synergistic water dispersible granular formulation comprising an Emamectin benzoate, 1 to 3% by weight of formulation and Profenofos, 32% to 40% by weight of formulation.
  • Yet another aspect of the present invention is that it synergistically acts to have excellent pesticidal utility in control of several Coleopteran and Lepidopteran species like Armyworm ( Spodoptera fugiperda), Fruit Borer (Helicoverpa armigera), Tobacco caterpillar (Spodoptera litura), Semilooper (Agrotis ipsilon), Bihar hairy Caterpillar (Spilosoma obliqua), Spotted Pod borer (Earias vittella), Bollworm complex-Fruit borer (Helicoverpa armigera), Pink Bollworm (Pectinophora gossypiella), Spotted bollworm (Earias vittella), Spiny bollworm (Earias insulana ), Fruit and shoot borer(Leucinodes orbonalis), Diamond back moth (Plutella xylostella), Pod Borer (Helicoverpa armigera), Looper caterpillar (Biston supress
  • Embodiments of the present invention disclose a synergistic and stable pesticidal granule formulation includes, an effective amount of a first ingredient and a liquid active ingredient.
  • the first ingredient is Emamectin benzoate and the liquid active ingredient is an organothiophosphate.
  • the liquid active ingredient is an organophosphate insecticide. Specifically, the liquid active ingredient is Profenofos.
  • the synergistic and stable pesticidal granule formulation is a synergistic and stable water dispersible granular formulation (WDG or WG).
  • Emamectin benzoate is present in a range of approximately 1 % to 3% by weight of formulation.
  • Profenofos is present in a range of approximately 32% to 40% by weight of formulation.
  • the present invention is related to a synergistic and stable pesticidal wettable granule formulation comprising an effective amount of Emamectin benzoate and Profenofos.
  • the present invention also relates to process for preparing the said stable granular formulation comprising an Emamectin benzoate, 1 to 3% by weight of formulation and Profenofos, 32% to 40% by weight of formulation.
  • An adjuvant used in the present invention to make it a stable, safe, free flowing, dustless dispersible granular formulation comprises inert fillers, surfactant, emulsifier, binder and wetting agent.
  • pestesticidally effective amount or“effective amount” means the amount of a pesticide needed to achieve an observable effect on a pest and/or activity of a pest in a locus; this effect may come about when pest populations are repulsed from a locus, pests are incapacitated in or around a locus and/or pests are exterminated in or around a locus. Of course, a combination of these effects can occur.
  • pest populations or activity or both are desirably reduced more than fifty percent, preferably more than 90 percent and most preferably more than 99 percent.
  • the formulation of present invention synergistically acts to have excellent effect on pests thus it has excellent pesticidal utility in control of pest.
  • Synergism is the interaction or cooperation of two or more organizations, substances, or other agents to produce a combined effect greater than the sum of their separate effects.
  • the phrase“synergistically effective amount” of the formulation means a sufficient amount of the formulation to provide the desired pesticidal effect.
  • the formulation is employed in amounts that do not cause phytotoxic damage to any part of the plant and also it is safe to natural enemies.
  • the amount of the formulation may vary depending on specific crops and other factors.
  • the formulation of present invention acts synergistically to control pest in various crops.
  • the pesticidal utility of present invention in excellent control of pest of several Coleopteran and Lepidopteran species in various crops is given in Table 1.
  • An adjuvant used in the present invention is any material that is added to an agrochemical formulation to enhance or modify the performance of the formulation.
  • An adjuvant used in the present invention to make it a stable, safe, free flowing, dustless dispersible granular formulation comprises inert fillers, surfactant, emulsifier, binder and wetting agent.
  • the term“adjuvants” is similar to“inactive excipients” and used interchangeably in this whole specification.
  • the synergistic composition further comprises one or more agriculturally acceptable adjuvants.
  • One or more inert fillers used herein can be selected from the group comprising of Water, Precipitated silica, Fused silica, Magnesium alumina silica, Calcium carbonate, Bentonite or a blend thereof.
  • Emulsifier used in the present invention is selected from the group comprising of Linear dodecylbenzene sulfonate calcium salt in 2- ethylhexanol solution, Benzenesulfonic acid, 4-C10-14-alkyl derivatives, calcium salts, Sodium dioctyl sulfosuccinate, Ethoxylated propoxylated polyarylphenol, Thiophospharyl succinate salt, Taurine derivatives (in particular alkyl taurate), Polyoxyethylene alcohol or Phenol phosphoric acid ester, Fatty acid esters of polyols.
  • Surfactant used in the present invention is selected from the group comprising of Sodium N-methyl-N-oleyl taurate (Commercially available with trade name Geropon T-77), 2,5-Furandione, polymer with 2,4,4- trimethylpentene, sodium salt (Commercially available with trade name Geropon T-36), an anionic surfactant of trade name Geropon SA, Sodium alkyl naphthalene sulfonate, Sodium naphthalene sulfonate, Calcium lignosulfonate, Sodium lignosulfonate, Ammonium lignosulfonate and mixtures thereof.
  • One or more binder used in the present invention is selected from the group comprising of Lactose, Polyvinylpyrrolidone K-30 (PVK-30), Starch, Nimbid, Xanthan gum, Agar-agar and Arabic gum or a mixture thereof.
  • titanium dioxide as whitening agent may be used in the present invention.
  • the synergistic and stable granular formulation of present invention is wettable granule formulation (WG) or water dispersible granular formulation (WDG).
  • the synergistic granular formulation of present invention is stable, safe, free flowing and dustless formulation.
  • Emamectin benzoate is present in the rage of 1 to 3% by weight of formulation and Profenofos is in the range of 32% to 40% by weight of formulation.
  • embodiments of the instant invention also relate to a process for preparing the said stable granular formulation and its pesticidal utility.
  • the formulation of present invention is stable and synergistically acts to have excellent pesticidal utility in control of Armyworm ( Spodoptera fugiperda), Fruit Borer (Helicoverpa armigera), Tobacco caterpillar (Spodoptera litura), Semilooper (Agrotis ipsilon), Bihar hairy Caterpillar (Spilosoma obliqua), Spotted Pod borer (Earias vittella), Bollworm complex- Fruit borer (Helicoverpa armigera), Pink Bollworm (Pectinophora gossypiella), Spotted bollworm (Earias vittella), Spiny bollworm (Earias insulana ), Fruit and shoot borer(Leucinodes orbonalis), Diamond back moth (Plutella xylostella), Pod Borer (Helicoverpa armigera), Looper caterpillar (Biston supressaria) and American bollworm (Spodoptera litura).
  • the present invention has excellent use in various crop family such as Poaceae, Solanaceae, Leguminaceae, Malvaceae, Brassicaceae, Fabaceae, Theaceae and Cucurbitaceae without causing harm to natural enemies.
  • a synergistic and stable pesticidal granule formulation includes, an effective amount of a first ingredient and a liquid active ingredient.
  • the first ingredient is Emamectin benzoate and the liquid active ingredient is an organothiophosphate.
  • the liquid active ingredient is an organophosphate insecticide. Specifically, the liquid active ingredient is Profenofos.
  • the synergistic and stable pesticidal granule formulation is a synergistic and stable water dispersible granular formulation (WDG).
  • WDG synergistic and stable water dispersible granular formulation
  • Emamectin benzoate is present in a range of approximately 1 % to 3% by weight of formulation.
  • Profenofos is present in a range of approximately 32% to 40% by weight of formulation.
  • the formulation further includes multiple adjuvants for making the formulation a stable, safe, free flowing, dustless and dispersible granular formulation.
  • the adjuvants are selected from a group including one or more inert fillers, one or more surfactants, one or more emulsifiers, one or more binders and one or more wetting agents.
  • the adjuvants are selected from a group including one or more agriculturally acceptable adjuvants.
  • the one or more inert fillers are selected from a group including of water, precipitated silica, fused silica, Magnesium alumina silica, Calcium carbonate, Bentonite or a blend thereof.
  • the one or more emulsifiers are selected from a group including of Linear dodecylbenzene sulfonate calcium salt in 2-ethylhexanol solution, Benzenesulfonic acid, 4- C10-14-alkyl derivatives, calcium salts, Sodium dioctyl sulfosuccinate, Ethoxylated propoxylated polyarylphenol, Thiophospharyl succinate salt, Taurine derivatives (in particular alkyl taurate), Polyoxyethylene alcohol or Phenol phosphoric acid ester, Fatty acid esters of polyols.
  • the one or more surfactants are selected from a group including of Sodium N-methyl-N-oleyl taurate (Commercially available with trade name Geropon T-77), 2,5- Furandione, polymer with 2,4,4-trimethylpentene, sodium salt (Commercially available with trade name Geropon T-36), an anionic surfactant of trade name Geropon SA, Sodium alkyl naphthalene sulfonate, Sodium naphthalene sulfonate, Calcium lignosulfonate, Sodium lignosulfonate, Ammonium lignosulfonate and mixtures thereof.
  • the one or more binders are selected from a group including of Lactose, Polyvinylpyrrolidone K-30 (PVK-30), Starch, Nimbid, Xanthan gum, Agar-agar and Arabic gum or a blend thereof.
  • the formulation further includes a whitening agent.
  • the whitening agent is titanium dioxide.
  • the formulation as disclosed herein is a synergistic and stable wettable granule formulation (WDG or WG).
  • the formulation as disclosed herein by way of one or more embodiments is capable of being employed in an amount that does not cause phytotoxic damage to any part of a plant and wherein the formulation is safe to multiple natural enemies.
  • the following examples are intended to illustrate, but in no way limit the scope of the present invention.
  • Table A and B are depicting the specification of Profenofos and Emamectin benzoate technicals used for the preparation of desired wettable granule (WDG or WG) formulation:
  • the stable synergistic wettable granule (WDG or WG) formulation with above desired composition can be prepared by following procedure:
  • Step -1 Preparation of active ingredient micronized mixture
  • Emamectin benzoate technical 1 .5 parts by weight of Emamectin benzoate technical was charged in pre- mixer blender. Add ppt. silica 20 parts under stirring to Emamectin benzoate technical followed by addition of lactose 20 parts at 30°C to 35°C. Stir the mixture for further 30 minutes. After completion of mixing, the grinding of mixture was done through jet mill to obtain micronized mass.
  • micronized mass add 35 parts by weight of Profenofos technical under stirring at 30°C to 35°C, mixing was continued for further 30 minutes to get homogenous active ingredients mass of particle size less than 75 microns.
  • Step-2 Preparation of surfactants slurry
  • Step-3 Preparation of granules
  • the stable synergistic wettable granule (WDG or WG) formulation with above desired composition can be prepared by the following procedure: Step -1 : Preparation of active ingredient micronized mixture
  • Emamectin benzoate technical 1.5 parts by weight of Emamectin benzoate technical was charged in pre-mixer blender. Subsequently, ppt. silica 22 parts were added under stirring to Emamectin benzoate technical followed by addition of lactose 15 parts at 30°C to 35°C. Subsequently, the mixture was stirred for further 30 minutes. After completion of mixing, the grinding of mixture was done through jet mill to obtain micronized mass.
  • Step-2 Preparation of surfactants slurry
  • Step-3 Preparation of granules
  • micronized powder of Step-1 was transferred into the bowl of FBD (Fluidized Bed Dryer cum processor), where it was fluidized by air under temperature 70°C to 80°C.
  • surfactant slurry of Step-2 was sprayed on micronized active ingredients mass at the flow rate of 5 ml to 10 ml per minute.
  • Temperature of FBD was gradually increased up to 90°C under air flow for maximum granulation.
  • obtained dry granules were sieved to get wettable granules in the size rage of 0.1 mm to 1.0 mm (moisture content ⁇ 3.0%).
  • Insects are the most diverse species of animals living on earth. Herbivorous insects are said to be responsible for destroying one fifth of the world's total crop production annually. Several Coleopteran and Lepidopteran species attack crops both in the field and in store. This causes major problem to plants. This problem has resolved by the present invention in excellent synergistic manner.
  • R&D study was performed with Emamectin 1.5% + Profenofos 35% WDG for studying the effect of the combination on Lepidopteran, Coleopteran and other pests.
  • the test molecule was evaluated against two major lepidopteron pest larvae in controlled lab conditions. Spodoptera litura (Tobacco caterpillar) and Helicoverpa armigera (American bollworm) were artificially reared for in House study purpose.
  • Example-4 Study on Spodoptera litura
  • Example-5 Study on Helicovema armiciera The study was conducted via leaf dip method. Cotton leaves were dipped in the test stock solution and then fed to 2 nd instar larvae of Helicoverpa armigera that had been kept under starvation for 12 hrs.
  • the Experiment in field was conducted in the Randomized block design fashion.
  • the pests considered for this experiment were Army worm (Spodoptera fugiperda) in Maize, Fruit borer ( Helicoverpa armigera) in Tomato and Tobacco caterpillar ( Spodoptera litura) on Soybean.
  • Example-6 Experiment on Maize ⁇ Zea mays
  • the spray was conducted in Maize against Army worm at the emergence of pest. 200 lit of water was used to spray 1 Acre area. The spray was conducted with the help of Battery operated Knapsack sprayer.
  • the spray was conducted in Tomato against Fruit Borer at the emergence of pest. 200 lit of water was used to spray 1 Acre area. The spray was conducted with the help of Battery operated Knapsack sprayer.
  • Example-8 Experiment on Tobacco caterpillar ( Spodoptera Litura) in Soybean The experiment was conducted in Madhya Pradesh, where experiment was laid out with a set of 9 treatments having 3 replications each.
  • the spray was conducted in Soybean against Tobacco Caterpillar, at the emergence of pest. 200 lit of water was used to spray 1 Acre area. The 5 spray was conducted with the help of Battery operated Knapsack sprayer.
  • the formulation of present invention was safe to natural enemies present in plant eco-system. The result was taken from 1 meter 2 area of sampling and tabulated in Table 9.
  • a method for preparing a synergistic and stable pesticidal granule formulation comprises the steps of: adding an effective amount of Emamectin benzoate in a range 5 of approximately 1% to 3% by weight of formulation; and, adding a liquid active ingredient as Profenofos in a range of approximately 32% to 40% by weight of formulation.
  • this formulation is, a synergistic and stable water dispersible granular formulation (WDG) or wettable granule formulation (WG).
  • the method further comprises the step of adding a plurality of adjuvants for making said formulation a stable, safe, free flowing, dustless and dispersible granular formulation.
  • the 15 further comprises the step of adding a whitening agent.
  • the whitening agent is titanium dioxide.
  • embodiments of the instant invention provide significant advantages over prior art.
  • embodiments of the present invention as disclosed hereinbelow disclose a stable and synergistic agrochemical wettable granule formulation having effective amount of high concentration of Profenofos, wherein the amount of liquid ingredient Profenofos is in the range of 32% to 40% by weight of formulation, along with adjuvants like inert fillers, surfactant, binder and wetting agent, wherein the preparation of stable, safe and efficacious granular formulation with more amount of liquid active ingredient by economically efficient and ecologically safe route is making the present invention not obvious to person skilled in the art.
  • the present invention provides the enhanced efficacious synergistic effect against various pest and has broad pesticidal utility in many crops.
  • Emamectin benzoate discloses the combination of Emamectin benzoate and one or more of the compound(s) selected from the group consisting of Profenofos as one of the group members.
  • the amount of any of the second compound selected from the group in combination with Emamectin benzoate is present in between 5%-21 %.
  • this prior art is claiming specifically azamethiphos, cypermethrin high-cis and fenoxycarb in combination with Emamectin benzoate.
  • the embodiments of present invention are specifically for Profenofos in combination with Emamectin benzoate in the synergistic, stable and safe wettable granule formulation present in higher amount in comparison to this prior art.
  • liquid active ingredient like Profenofos has lower melting point in comparison to azamethiphos, cypermethrin high-cis and fenoxycarb as claimed in prior art.
  • the granules of present invention are dustless and free flow with other advanced quality of formulation like not phytotoxic and safer to natural enemies along with synergistic pesticidal utility against coleopteran and lepidopteran species which are the major problematic pest of present scenario, therefore the present invention is a technically advanced step in comparison to prior art also it is not obvious to a person skilled in the art. Further, the present invention is fulfilling the long felt need.
  • embodiments of the present invention disclose the formulation comprising high percentage of liquid active ingredient Profenofos along with Emamectin benzoate, which is difficult to prepare as per the disclosures of the prior art. Also, the formulation of the present invention is stable and has broad pesticidal utilities.
  • the embodiments of the present invention disclose synergistic and stable wettable granule formulations comprising Emamectin benzoate and Profenofos as active ingredients with other inactive excipients, having excellent pesticidal utility with the following advantages:
  • Granular formulation is stable, safe, free flowing, dustless dispersible granular formulation comprising Profenofos a liquid active ingredient in 32% to 40% by weight of formulation and can be prepared without much complex manufacturing process.
  • Granular formulation of present invention synergistically acts in wider aspect in control of pest in various crops.
  • the granules of the present invention typically have an average particle size in the range between about 0.1 mm to about 1.0 mm.
  • the granules of present invention virtually can be in any desired shape, for example, spheres, cylinders, ellipses, rods, cones, discs, needles and irregular shapes.
  • the granules are approximately spherical and cylinders, which lends to desired flow characteristics of the granules in bulk form.
  • Granular formulation have significant advantages in packaging, ease of handling and safety and phytotoxicity relative to liquid formulations
  • Granular formulation of present invention results in significant grain yield after crop treatment.
  • Granular formulation of present invention is safe by having no harmful effects on natural enemies.

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  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention concerne une formulation de granulés pesticides synergique et stable comprenant une quantité efficace d'un premier ingrédient et d'un ingrédient actif liquide. En utilisation, le premier ingrédient est le benzoate d'émamectine et l'ingrédient actif liquide est un organothiophosphate. Dans un autre mode de réalisation, l'ingrédient actif liquide est un insecticide organophosphaté. Plus précisément, l'ingrédient actif liquide est le profénofos. La formulation de granulés pesticides synergique et stable est une formulation granulaire dispersible dans l'eau synergique et stable (WDG ou WG). De plus, le benzoate d'émamectine est présent dans une plage d'environ 1 % à 3 % en poids de formulation. En utilisation, le profénofos est présent dans une plage d'environ 32 % à 40 % en poids de formulation.
PCT/IN2019/050269 2018-09-03 2019-03-31 Formulation de granulés mouillables pesticides synergique comprenant du benzoate d'émamectine et du profénofos WO2020049584A1 (fr)

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IN201811033003 2018-09-03
IN201811033003 2018-09-03

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2363023A1 (fr) * 2010-03-04 2011-09-07 Basf Se Mélanges insecticides et fongicides synergiques
US8846569B2 (en) * 2009-12-04 2014-09-30 Merial Limited Pesticidal bis-organosulfur compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846569B2 (en) * 2009-12-04 2014-09-30 Merial Limited Pesticidal bis-organosulfur compounds
EP2363023A1 (fr) * 2010-03-04 2011-09-07 Basf Se Mélanges insecticides et fongicides synergiques

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