WO2020049388A1 - Stérilisateur à plasma - Google Patents

Stérilisateur à plasma Download PDF

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Publication number
WO2020049388A1
WO2020049388A1 PCT/IB2019/056964 IB2019056964W WO2020049388A1 WO 2020049388 A1 WO2020049388 A1 WO 2020049388A1 IB 2019056964 W IB2019056964 W IB 2019056964W WO 2020049388 A1 WO2020049388 A1 WO 2020049388A1
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WO
WIPO (PCT)
Prior art keywords
microplasma
sterilization
microplasma generating
chamber
item
Prior art date
Application number
PCT/IB2019/056964
Other languages
English (en)
Inventor
Boaz Nitzan
Yuval SHILDERMAN
Original Assignee
Tuttnauer Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tuttnauer Ltd. filed Critical Tuttnauer Ltd.
Publication of WO2020049388A1 publication Critical patent/WO2020049388A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/14—Plasma, i.e. ionised gases
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J37/00—Discharge tubes with provision for introducing objects or material to be exposed to the discharge, e.g. for the purpose of examination or processing thereof
    • H01J37/32—Gas-filled discharge tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A61L2/06—Hot gas
    • A61L2/07—Steam
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2240/00—Testing
    • H05H2240/10—Testing at atmospheric pressure
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2240/00—Testing
    • H05H2240/20—Non-thermal plasma
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2245/00—Applications of plasma devices
    • H05H2245/30—Medical applications
    • H05H2245/36—Sterilisation of objects, liquids, volumes or surfaces

Definitions

  • the present invention relates to a plasma sterilizer. Moreover, the present invention is of a microplasma sterilizer and use thereof in sterilization.
  • Sterilization is carried out routinely in many industries and on diverse items, such as those related to the medical and food industries.
  • One device routinely used for sterilization is an autoclave.
  • the autoclave can provide high pressure steam sterilization.
  • Cold plasma sterilization offers an alternative method of sterilization and may be especially advantageous for heat sensitive or water sensitive materials, which cannot withstand the autoclave conditions.
  • Cold plasma sterilization may also offer the advantage of being quicker to kill microorganisms than steam sterilization.
  • Cold non-equilibrium atmospheric pressure plasma can be produced by high voltage discharges in the atmospheres of various gases, such as electric arc discharges, corona discharges and dielectric barrier discharges. These high voltage methods suffer from safety problems and are not cost effective.
  • Plasma sterilizers have been described wherein the plasma is generated in a separate chamber than the items to be sterilized and is spread by diffusion to the sterilization chamber. Plasma sterilizers have also been described, wherein the plasma is generated directly in the sterilization chamber. Both types suffer from disadvantages of plasma density and non-homogeneity, which is influenced by the amount and type of articles being sterilized. This type of sterilization is problematic with irregular shaped items and articles with apertures, where all the surfaces may not be exposed to the plasma. A further shortcoming is that the amount of ions produced by these sterilizers may be low.
  • the invention may have several aspects.
  • One aspect is a sterilization device.
  • the sterilization device may feature at least one sterilization chamber in which to sterilize at least one item.
  • the sterilization device may feature at least one microplasma generating system for generating microplasma, the microplasma for sterilizing the at least one item, wherein the at least one microplasma generating system is connected to the at least one sterilization chamber.
  • the sterilization device may feature at least one distribution system for distributing a microplasma generating material to the microplasma generating system, wherein the at least one distribution system is connected to the at least one microplasma generating system.
  • the sterilization chamber may be at ambient pressure.
  • the at least one sterilization chamber may include a closeable inlet for receiving air through the inlet and into the at least one microplasma generating system.
  • the at least one microplasma generating system and the at least one item may be positioned within the at least one sterilization chamber.
  • the at least one microplasma generating system may include at least one array of connected microchannels configured to produce microplasma.
  • the microchannels may include spaced apart electrodes configured when a voltage is applied to produce a microplasma from a microplasma generating material introduced in the microchannel.
  • the device may include a plurality of the at least one microplasma generating systems.
  • the at least one array may feature an array of a plurality of microchannels wherein the electrodes are dielectrically isolated from the microchannels.
  • the at least one array may include at least one inlet for the microplasma generating material and at least one outlet for the formed microplasma.
  • the at least one of the at least one inlet and the at least one outlet may include a filter.
  • the at least one array may be a modular array, which may include at least one attachment means for connecting to at least one additional at least one array.
  • the at least one array may be held in a housing.
  • the housing may be a gas permeable container.
  • the gas permeable container may include at least one inlet for introducing the microplasma generating material into the microchannels and at least one outlet for providing the microplasma formed in the microchannels to the at least one item.
  • the shape of the at least one array may be at least one of square, rectangular, circular, oval, triangular, multisided, wafer, flat and bulky.
  • the shape of the at least one array may be configured in the shape of the at least one item to be sterilized or in the shape of at least part of the at least one item to be sterilized.
  • the at least one array may be flexible.
  • the shape of the housing may be in at least part of the shape of the at least one item to be sterilized.
  • the shape of the at least one microplasma generating system may be at least one of square, rectangular, circular, oval, triangular, multisided, wafer, flat and bulky.
  • the at least one microplasma generating system may be attached to a surface of a cavity of the at least one sterilization chamber.
  • a plurality of microplasma generation systems may be attached in spaced apart relation on all the walls of the sterilization chamber.
  • the at least one microplasma generating system may cover the surfaces of the sterilization chamber.
  • the microplasma generating system may include attachment means for attaching to the sterilization device.
  • the sterilization device may include attachment means for attaching the at least one microplasma generating system to the sterilization device.
  • the at least one sterilization chamber may include attachment means for attaching the at least one microplasma generating system to the sterilization device.
  • the microplasma generating system attachment means may include tabs which correspond to attachment means in the sterilization device comprising slots.
  • the sterilization device may include a power source.
  • the power source may supply a power of from about 10W to about 500W to facilitate microplasma generation and sterilization.
  • the at least one microplasma generating system may be in electrical connection with a power source for providing the voltage to form the microplasma.
  • Attachment means of the sterilization device may be configured to attach the at least one microplasma generating system to the sterilization device and facilitate electrical connection with a power source for providing the voltage to form the microplasma.
  • Attachment means of the sterilization device may be configured to attach the at least one microplasma generating system to the sterilization device and connect the at least one microplasma generating system to the at least one distribution system.
  • the sterilization device may include at least one shelf constructed from a gas permeable material for holding the at least one item to be sterilized.
  • the at least one shelf may include at least one divider to prevent contact between more than one item of the at least one items placed on the shelf.
  • the sterilization device may include a plurality of shelves positioned in spaced relation in a horizontal plane or in vertical relation to each other.
  • the at least one shelf may be positioned at the center of the at least one sterilization chamber of the sterilization device.
  • the at least one shelf may be fixed or removable.
  • the sterilization device may include at least one hook on a surface of the at least one sterilization chamber for holding the at least one item to be sterilized.
  • the at least one hook may be a plurality of hooks in spaced apart relation to hold apart each item of a plurality of the at least one items.
  • the at least one microplasma generating system may be attached to an exterior surface of the at least one sterilization chamber.
  • the sterilization device may include at least one container for storing the microplasma generating material.
  • the microplasma generating material may be at least one gas.
  • the at least one gas may be at least one of oxygen, hydrogen, nitrogen, helium, argon and air.
  • the at least one distribution system may include at least one channel for providing the plasma generating material into at least one inlet of the at least one microplasma generating system.
  • the at least one channel may be tubing.
  • the at least one channel may be connected to and extends from at least one container for storing the microplasma generating material to each microplasma generating system of the at least one microplasma generating systems and the at least one channel may include a plurality of closeable outlets, a closeable outlet for connecting to the at least one inlet of each microplasma generating system of the at least one microplasma generating systems.
  • the sterilization device may include a pump for pumping the microplasma generating material through an inlet in the at least one microplasma generating system.
  • the sterilization device may include a spray element connected to the at least one outlet of the at least one microplasma generating system, the spray element for spraying the microplasma onto the at least one item.
  • the sterilization device may include a control, the control providing a means of starting and stopping a sterilization cycle.
  • the sterilization device may include a timer for setting the cycle time for a sterilization cycle and wherein the cycle time is configured for providing exposure for a sterilizing effect of the at least one item to a combination of plasma product, ions, photons, free radicals and electrons.
  • the sterilization device may include a fan to distribute the microplasma.
  • the sterilization device may be for sterilizing at least one item of dental equipment, medical equipment, food equipment and beverage equipment.
  • the sterilization device may include an inlet for providing at least one additional sterilizing agent to the sterilization chamber.
  • the sterilization device with an inlet for providing at least one additional sterilizing agent to the sterilization chamber may be for providing sterilization of the at least one item by the microplasma and the at least one additional sterilizing agent.
  • the sterilization device may be an autoclave.
  • the sterilization device may be configured to provide at least one of steam sterilization and plasma sterilization.
  • the at least one microplasma generating system may be electrically connected to the power source of the autoclave.
  • the sterilization device may include a control, the control providing a means of starting and stopping at least one of steam sterilization and plasma sterilization.
  • An additional aspect is a sterilization device, which may include at least one microplasma generating system, which may feature a plurality of arrays of connected microchannels configured to produce microplasma for sterilization of at least one item.
  • a further aspect is a system for plasma sterilization.
  • the system may feature a sterilization chamber.
  • the sterilization chamber may include spaced apart chamber attachment means affixed on the surfaces of the sterilization chamber and at least one chamber inlet for providing microplasma generating material to the system, the at least one inlet adjacent to the spaced apart attachment means.
  • the system may include at least one array of connected microchannels configured to produce microplasma, wherein the microchannels my feature spaced apart electrodes arranged to produce a microplasma from a microplasma generating material introduced in the microchannel when a voltage is applied.
  • the at least one array may include attachment means corresponding to the chamber attachment means for attaching the at least one array to the sterilization chamber and at least one connectable inlet for connecting to the chamber inlet.
  • the system may include at least one power source connected to the at least one array of connected microchannels for supplying the power to form microplasma in the microchannels.
  • a still further aspect is at least one array of connected microchannels configured to produce microplasma.
  • the microchannels may feature spaced apart electrodes configured when a voltage is applied to produce a microplasma from a microplasma generating material introduced in the microchannel.
  • the at least one array may include attachment means corresponding to attachment means in a sterilization chamber of a sterilization device for attaching the at least one array to the sterilization chamber and at least one connectable inlet for connecting to an inlet of a sterilization device and facilitating flow of a microplasma generating material into the microchannels.
  • the at least one array is a plurality of arrays and one array is connectable to at least one other array of the plurality of arrays.
  • the at least one array may be contained in a container.
  • the container may include attachment means corresponding to attachment means in a sterilization chamber of a sterilization device for attaching the at least one array to the sterilization chamber.
  • the container may include at least one connectable inlet for connecting to an inlet of a sterilization device and facilitating flow of a microplasma generating material into the microchannels.
  • the container may include at least one outlet for providing the sterilization chamber with microplasma produced in the microchannels.
  • Another aspect is a sterilization device configured for sterilizing at least one item.
  • the sterilization device may feature a sterilization chamber.
  • the sterilization chamber may include at least one array of connected microchannels configured to produce microplasma.
  • the at least one array may include a plurality of outlets for the formed microplasma, the plurality of outlets spaced apart and configured in the shape of the at least one item.
  • the sterilization chamber may include a shelf for holding the at least one item, the shelf positioned for proximity to the plurality of outlets and contact of the microplasma with the surfaces of the at least one item.
  • An aspect is a method of sterilizing at least one item.
  • the method may include placing an item in the at least one sterilization chamber of a sterilization device as described hereinabove.
  • the method may include introducing a plasma generating material into the microchannels.
  • the method may include applying a voltage to the microchannels and producing a microplasma and exposing the at least one item to be sterilized to the microplasma.
  • the placing may include placing an item on a shelf made from a gas permeable substance.
  • the placing may include attaching the at least one item to a hook on the sterilization chamber.
  • the plasma generating material may be at least one of oxygen, hydrogen, nitrogen and air.
  • the introducing may feature pumping the plasma generating material through an inlet of the at least one microplasma generating system and into the microchannels.
  • the applying a voltage may include applying a voltage of from about 300V to 2kV and a power of from about 10W to about 500W.
  • the method may include exposing the at least one item to the microplasma for a cycle time of from about 30 seconds to about 30 minutes.
  • An aspect is a method of sterilization featuring supplying a system for plasma sterilization as described hereinabove.
  • the method includes placing at least one item in the sterilization chamber for exposure to the microplasma and sterilization by the microplasma.
  • the method includes attaching the at least one array of connected microchannels to the sterilization chamber, such that the at least one inlet of the at least one array is connected to the at least one chamber inlet.
  • the method includes introducing into the microchannels a microplasma generating material and supplying the power to the at least one array to form microplasma in the microchannels.
  • An aspect is a method of combination sterilization.
  • the method may include placing an item in the sterilization chamber of a sterilization device configured to provide at least one of steam sterilization and plasma sterilization as described herein.
  • the method may include running a steam sterilization cycle and running a plasma sterilization cycle.
  • the autoclave may be a steam sterilizer.
  • Running a plasma sterilization cycle may include introducing a plasma generating material into the microchannels, applying a voltage to the microchannels and producing a microplasma and exposing the item to be sterilized to the microplasma.
  • the method may include running a steam sterilization cycle first and then running the plasma sterilization cycle.
  • the method may include running a plasma sterilization cycle first, followed by a steam sterilization cycle.
  • Running the plasma sterilization cycle may be for less than one minute.
  • Running the steam sterilization cycle may be for about half an hour.
  • An aspect is a method of generating microplasma.
  • the method may include providing a plasma sterilization device as described herein.
  • the method may include connecting the sterilization device to a power supply, so the power supply is in electrical connection with the at least one microplasma generating system.
  • the method may include supplying microplasma generating material to the at least one microplasma generating system.
  • the method may include applying a voltage to the microchannels for formation of microplasma in the microchannels.
  • the supplying microplasma generating material may include supplying microplasma generating material to the at least one distribution system in communication with the at least one microplasma generating system.
  • the supplying microplasma generating material may include delivering microplasma generating material into outlets of channels of the at least one distribution system.
  • the supplying microplasma generating material may include delivering microplasma generating material through the open outlets of the channels of the at least one distribution system into inlets of the at least one microplasma generating system and into the microchannels of the at least one microplasma generating system.
  • the supplying microplasma generating material may include closing and opening of the outlets of the at least one distribution system before the supplying of the microplasma generating material.
  • the method of generating microplasma may include stopping microplasma generation. Stopping microplasma generation may feature at least one of stopping the power supply to the at least one microplasma generating system and closing the outlets of the channels of the at least one distribution system.
  • FIGs la-ld show schematic views of exemplary sterilizing devices according to an aspect of the present invention.
  • FIGs 2a-2c show schematic views of exemplary sterilizing devices according to an aspect of the present invention.
  • FIGs 3a-3c show schematic views of exemplary microplasma generating units and arrays according to an aspect of the present invention
  • FIGs 4a-4d show schematic views of exemplary microplasma generating systems according to an aspect of the present invention.
  • FIGs 5a-5d show schematic views of exemplary microplasma generating systems according to an aspect of the present invention.
  • FIG. 6 shows a schematic view of an exemplary sterilization device for sterilization of dental equipment according to an aspect of the present invention
  • FIGs 7a-7g show schematic views of an exemplary sterilizing device with an exemplary microplasma generating system according to an aspect of the present invention
  • FIGs 8a-8h shows schematic views of exemplary holding means for holding a microplasma generating system in a sterilizing device according to an aspect of the present invention
  • FIGs 9a-9b show schematic views of exemplary sterilizing devices with microplasma generating systems external to the sterilization chamber according to an aspect of the present invention
  • Figs lOa-lOd show schematic views of an exemplary plasma generating material distribution system according to an aspect of the present invention
  • FIGs l la-l lg show schematic views of exemplary means to hold an item to be sterilized in a microplasma device according to an aspect of the present invention
  • FIG 12 shows a schematic view of exemplary sterilization compartments according to an aspect of the present invention.
  • FIG. 13 shows a schematic view of an exemplary sterilization device with a control according to an aspect of the present invention
  • FIGs l4a-l4b show schematic views of an exemplary combination steam sterilizer and plasma sterilizing device according to an aspect of the present invention
  • FIG. 15 shows a schematic view of an exemplary autoclave converted to a plasma sterilizer according to an aspect of the present invention
  • FIGs 16a- 16c show schematic views of an exemplary sterilizing system according to an aspect of the present invention.
  • FIG. 17 shows a flow chart of an exemplary method of generating microplasma according to an aspect of the present invention
  • FIG. 18 shows a flow chart of an exemplary method of sterilization according to an aspect of the present invention
  • FIG. 19 shows a flow chart of an exemplary method of sterilization according to an aspect of the present invention
  • FIG. 20 shows a flow chart of an exemplary method of sterilizing according to an aspect of the present invention
  • FIG. 21 shows a flow chart of an exemplary method of sterilization using a combination steam sterilizer and microplasma sterilizer according to an aspect of the present invention
  • FIG. 22 shows a flow chart of an exemplary method of sterilization using a combination steam sterilizer and microplasma sterilizer according to an aspect of the present invention
  • FIG. 23 shows a flow chart of an exemplary method of sterilization using a combination steam sterilizer and microplasma sterilizer according to an aspect of the present invention.
  • FIG. 24 shows a flow chart of an exemplary method of production of a plasma sterilizer according to an aspect of the present invention.
  • the present invention is of a sterilization device.
  • the device may be a microplasma sterilization device.
  • the present invention provides a system for microplasma sterilization.
  • the present invention is of a combination steam sterilization and microplasma sterilization system.
  • the present invention provides a microplasma generating system for use in a sterilization device.
  • the present invention provides methods of sterilizing an item using a system or device of the present invention.
  • the present invention provides a method of generating microplasma.
  • the system of the present invention has many advantages. It provides faster sterilization than with steam sterilization.
  • the microplasma system may have a power consumption of from about 10W to about 500W, whereas the power consumption of a plasma sterilization system of the art may be from about 1000W to greater than about 5000W.
  • the microplasma system obviates the need for the high power employed in plasma sterilization systems and is therefore relatively non-costly and safe.
  • the modularity of the microplasma producing units facilitates a system that can be adapted to each item being sterilized.
  • the modularity of the microplasma producing units also provides a way of providing more microplasma, by connecting in any suitable way a plurality of the units.
  • microplasma producing units By stacking the microplasma producing units, producing more microplasma is not reliant on the surface area of the sterilization device.
  • the system enables uniform sterilization of any shape and size of item.
  • the micro plasma system of the present invention provides a high concentration of plasma when compared with non-micro plasma sterilization systems. The chance that the microplasma generating material will be converted to microplasma in the very small microchannels is greater than in a system with larger dimensions, as the energy it obtains from the electrical field is greater.
  • the term ‘plasma’ may include the product/s resulting from applying a sufficient electric or magnetic field to a plasma or microplasma generating material.
  • the term may include, but is not limited to an ionized gas of negatively charged unbound electrons and positively charged ions.
  • the term may include free radicals.
  • the plasma’s activated species may also include atoms, molecules, metastables and photons.
  • the term may sometimes be used herein to include the term ‘microplasma’.
  • the term may include plasma breakdown products. The products may interact with any surface they contact.
  • microplasma may include the product/s resulting from applying a sufficient electric or magnetic field to a microplasma generating material in a microplasma generating device.
  • the term may include, but is not limited to a plasma of small dimensions. The small dimensions may include from about tens to thousands of micrometers.
  • the term may include microplasma breakdown products. The products may interact with any surface they contact.
  • plasma breakdown product’ or‘plasma product’ may include any product or species derived from the plasma or resulting from reverting or conversion to different energy states or reaction between species and components of the plasma soup.
  • microplasma breakdown product or ‘microplasma product’ may include any product or species derived from the microplasma or resulting from reverting or conversion to different energy states or reaction between species and components of the microplasma soup.
  • microplasma generating material or ‘plasma generating material’ or ‘plasma starting material’ or ‘microplasma starting material’ may include, but is not limited to any suitable material, which can be converted into microplasma and microplasma products using the conditions of the devices and systems of the present invention.
  • microplasma generating system may include, but is not limited to any suitable system which can convert a microplasma generating material into microplasma on application of a suitable electric or magnetic field.
  • microchannel may include, but is not limited to any suitable channel with a diameter of less than about 2mm.
  • the term‘distribution system’ may include, but is not limited to any suitable means for providing a material from a first location to a second location.
  • the term includes providing a material from one part of a system to another part of a system.
  • sterilization chamber may include, but is not limited to a compartment of a sterilization device where sterilization may be carried out.
  • connection may include, but is not limited to direct and indirect attachment.
  • inlet may include, but is not limited to a means of entry. The term may include any suitable means of entry, such as, but not limited to vents, ducts, pipes, flues and openings.
  • outlet may include, but is not limited to a means of exit.
  • the term may include an opening or passage configured for letting something out.
  • the term may include vents, pipes, ducts and exits for expelling something.
  • channel may include, but is not limited to a passage or a structure, which provides a passage or pathway for a material, such as a gas, vapor or liquid to flow along.
  • the tern may include a channel made from a material resistant to the material it is carrying.
  • the term may include a channel for a separated passage of a material.
  • the term ‘sterilization’ may include, but is not limited to elimination, killing, removal or deactivation of biological agents, such as, but not limited to microorganisms, pathogens, bacteria, viruses, fungi, spore forms and prions from a specified region. Sterilization may be performed using a sterilization process and may run for longer than is required to provide a sterility assurance level. The term may include a process providing a sterility assurance level of at least 10 6 .
  • the term‘disinfection’ may include, but is not limited to a process to destroy microorganisms on a specified region.
  • the term includes a method, which is less effective than sterilization at killing microorganisms and may not kill all microorganisms on a specified area, such as resistant bacterial spores.
  • sterilization cycle may include, but is not limited to at least one stage of a sterilization procedure.
  • the sterilization cycle may include all the stages of the sterilization procedure or only at least one stage.
  • FIG. la shows a schematic view of an exemplary sterilizing device 10 according to an aspect of the present invention.
  • the sterilization device may feature a sterilizing chamber 12.
  • the sterilizing chamber 12 may be any suitable sterilizing chamber and may be constructed from any suitable material, such as, but not limited to stainless steel or polycarbonate.
  • the sterilizing chamber 12 may be of any suitable size and shape for sterilizing at least one item.
  • the sterilization chamber may be a chamber to be sterilized itself, such as, but not limited to an incubator or a refrigerator for sterilization of the incubator or refrigerator.
  • Figures la-ld show an example of a square shaped sterilizing chamber 12, however this is not intended to be limiting.
  • the sterilizing chamber 12 may be a single chamber or may include multiple chambers l2a or multiple sub compartments l2a as shown schematically in Figure lb.
  • the sterilizing chamber 12 may include any suitable door, which can be closed during a sterilization cycle.
  • the door may include any opening and closing mechanism, such as, but not limited to being slide able or hanging on hinges. The door is not shown in the Figures.
  • the sterilizing device 10 may include at least one inlet 14 for providing a gas 16 or other microplasma generating material 16 to a microplasma generating means 18.
  • a first end 15 of the at least one inlet 14 may be in communication with a store of the gas or other microplasma generating material 16.
  • the second end 17 of the at least one inlet 14 may be in communication with a microplasma generating means 18.
  • the at least one inlet 14 is positioned on the ceiling 24 of the sterilizing device 10 and extends into the sterilizing chamber 12.
  • the at least one inlet 14 is positioned on any suitable surface of the sterilizing device 10, which facilitates access of the at least one inlet 14 to a microplasma forming material 16 and provides a means of transporting such as a passage for the plasma forming material 16 to the microplasma generating system 18.
  • the microplasma generating material 16 may be any material which can produce microplasma as a result of a sufficient electric or magnetic field and wherein the produced plasma has sterilizing properties.
  • suitable materials 16 include liquids, gases, vapors and air and combinations thereof, such as but not limited to at least one of hydrogen peroxide, oxygen, hydrogen, helium, argon and nitrogen.
  • the suitable material 16 when in suitable microplasma generating conditions may be excited to higher energy states and may produce, plasma ions, atoms, metastables, electrons, photons and free radicals. The release of photons may result from the atoms and molecules relaxing to their normal lower energy states.
  • microplasma products wherein oxygen is the microplasma generating material may include 0 2 + , 0 2 , 0 3 (ozone), O, 0 + , O , ionized ozone, metastable excited oxygen and free electrons.
  • the sterilizing device 10 may include a pump 20 for pumping the plasma starting material 16 through the inlet 14 and into the microplasma generating means 18. Any suitable pump 20 may be used.
  • the sterilizing device 10 may include a reservoir container 22 for storing the plasma starting material 16.
  • the material 16 may be pumped from the atmosphere without the use of a reservoir container 22.
  • the plasma generating material container 22 may be of any suitable size and shape and constructed from a material non-reactive with the stored plasma starting material 16.
  • the container 22 may be attached to the sterilizing device 10 in any suitable way for providing the microplasma generating means 18 with the plasma starting material.
  • the container 22 is connected to the ceiling 24 of the sterilizing chamber 12. However, the container 22 may be disposed on any surface of the sterilizing chamber 12.
  • the sterilizing device 10 may include a plurality of reservoir containers 22, which may be attached to more than one side of the sterilizing device 10, such as shown schematically in Figure lc.
  • Each reservoir container 22 of a plurality of reservoir containers 22 may include the same plasma starting material 16, a different plasma generating material 16 or a combination of more than one plasma generating materials 16.
  • the reservoir container 22 may include at least one inlet 26 and at least one outlet 28.
  • the inlet 26 may be for introducing plasma starting material 16 into the reservoir 22.
  • the outlet 28 may be for dispensing the plasma starting material 16 to the microplasma generating system 18.
  • the outlet 28 of the reservoir container 22 may replace and function as the previously described inlet 14.
  • At least one reservoir 22 of the plurality of reservoirs may be for storing a sterilizing material 29, which is provided to the chamber 12 and is not connected to or generated into plasma via the microplasma generating system 18.
  • the sterilizing material 29 may provide a sterilizing effect in addition and/or in combination with the microplasma products.
  • the microplasma products may include a material, which is the same as the separately applied sterilizing material 29.
  • a suitable sterilizing material 29, which can be introduced directly into the chamber 12 and not via the microplasma generating system 18 is ozone.
  • the same plasma generating material 16 may be supplied to the at least one or a plurality of microplasma generating devices 18 as shown schematically in Figure 2a.
  • the reservoir container 22 is a plurality of reservoir containers 22 each container 22 storing a different plasma generating material 16
  • the containers 22 may supply a different plasma generating material 16 to the microplasma generating devices 18, according to which plasma generating material is connected to which microplasma generating device 18 as shown schematically in Figure 2b.
  • a combination of different microplasmas may be formed in the sterilization device 10.
  • the container 22 may supply a combination of micro plasma generating materials to a microplasma generating system 18, resulting in a mixture of different plasmas being formed as shown schematically in Figure 2c.
  • the sterilizing device may include any suitable microplasma generating system 18.
  • the microplasma generating system 18 may include any suitable microplasma chip generating system.
  • the semiconductor chip may contain channels with a diameter of less than about a millimeter, which are contained in a network of conductors. The conductors may be connected to a generator for creating an electric field around each microchannel.
  • suitable microplasma generating units and systems 18 for use in the present invention include those described by Prof. Gary Eden, such as, but not limited to those disclosed in WO 2009/140509 and US 20150270110A1.
  • the microplasma generating system may include a microplasma generating unit 30.
  • FIG. 3a shows a schematic view of an exemplary microplasma generating unit 30 according to an aspect of the present invention.
  • the microplasma generating unit 30 may feature at least two electrodes 32, 34 arranged about a microchannel 36.
  • Each electrode 32, 34 may be a continuous electrode or may be split into a plurality of spaced apart electrodes.
  • Figure 3a shows a schematic view of the non limiting example of a plurality of continuous electrodes 32, 34.
  • the electrodes 32, 34 may be made from any suitable material such as, but not limited to copper, silver, gold aluminum, and titanium.
  • the microchannel 36 may be made from any suitable material, such as, but not limited to aluminum oxide and titanium dioxide and polycarbonate.
  • the microplasma generating unit 30 may include an inlet 38 for providing plasma generating material 16 to the microchannel 36.
  • the microplasma generating unit 30 may include an outlet 40 for providing the formed microplasma 42 to the sterilizing device 10.
  • the electrodes 32, 34 may be dielectrically insulated from each other with a dielectric substance 46. Suitable non-limiting examples of dielectric substances 46 include, but are not limited to metal oxides.
  • the electrodes 32, 34 may be connected to a power source 48. Suitable power sources 48 may provide sufficient power and may include at least one of AC, DC, battery, photovoltaic power source, solar power source, RF and microwave. In some embodiments, the power source 48 is a generator.
  • the power source 48 may be configured to provide sufficient power to generate microplasma 42 from the plasma generating material 16.
  • the power source 48 may provide power in the range of from about 10W to about 500 W.
  • the electrodes 32, 34 may be configured such that when a plasma generating material 16 is introduced in the microchannel 36 and a sufficient voltage of from about 0.3KV to about 3KV is applied, a microplasma 42 is formed.
  • the sterilizing device may include a control/s to control the frequency and the voltage.
  • the extent of conversion of the plasma generating material 16 to microplasma 42 may be influenced by the time of the plasma generating material 16 in the microchannel 36, the amount of the material, the properties of the material and the power applied.
  • the rate of a pump used to pump plasma generating material 16 into the microplasma generating unit 30 may be set for optimal plasma generation.
  • the microplasma generating unit 30 may be configured in any shape and any size.
  • the microplasma generating unit 30 may be constructed very thin like a wafer. In some embodiments the unit 30 may be constructed with a thickness of from about 1 mm to about 30mm.
  • the size of a microplasma generating unit 30 may be from about 10mm by 10mm to about 100mm by 100mm.
  • the microplasma generating unit 30 may include attachment means 50 for modular attachment of a microplasma generating unit 30 to at least one other microplasma generating unit 30. In one embodiment, a plurality of microplasma generating units 30 are formed as a connected array 52 as shown schematically in Figure 3b.
  • the connected array 52 may include an inlet 51 for supplying microplasma generating material to the inlet 38 of each microplasma generating unit.
  • the connected array 52 may include an outlet 53 for supplying the microplasma 42 formed in the microchannels of each microplasma generating unit 30.
  • Arrays of microplasma generating units 52 may be joined in any suitable way to each other, which may include, but is not limited to side by side, stacked and rolled.
  • the microplasma generating system 18 of the present invention may include an array 52 or a plurality of arrays of connected microplasma generating units 30.
  • the microplasma generating system 18 may include a container 54 for holding the array of microplasma generating units 52 as shown schematically in FIG. 3c.
  • the container 54 may function as a housing for the microplasma generating system 18.
  • the container 54 may include at least one inlet 56 and at least one outlet 58, the at least one inlet 56 configured to supply microplasma forming material 16 to the microchannels 36 of each microplasma generating unit 30 in the system 18 and the at least one outlet 58 configured to provide the formed microplasma 42 to the sterilization chamber 12 or other unit in which it is disposed.
  • the microplasma system container 54 may be of any suitable size and shape. In some embodiments, the microplasma system container 54 may be flexible.
  • the container 54 may be sufficiently flexible to be manipulated and shaped according to the needs of a user.
  • Figure 4a shows a schematic view of an exemplary microplasma generating system 18, which features an array of microplasma generating units 52 held in a container 54 in a rectangular shape.
  • Figure 4b shows a schematic view of an exemplary microplasma generating system 18, which features an array of microplasma generating units 52 held in a container 54 in a flat circular shape.
  • Figure 4c shows a schematic view of an exemplary microplasma generating system 18, which features an array of microplasma generating units 52 in a container 54 in a cylindrical shape.
  • the present invention provides devices and systems in which at least one microplasma generating system 18 is built in or integrally formed in any suitable way with the device or system.
  • the present invention also provides a standalone microplasma generating system 18, which can be used with any suitable device and can be attached to that device.
  • a standalone microplasma generating system 18 may be any microplasma generating system as described herein.
  • the standalone microplasma generating system 18 may include at least one attachment means 70 for attaching to any device or system such as a plasma sterilizer 10.
  • a standalone microplasma generating system 18 is shown schematically in Figure 4d.
  • a microplasma generating system 18 can be made in the shape of the item 60 to be sterilized and/or with a plurality of microplasma outlets 58 which correspond to the contour and surfaces of the item 60 to be sterilized.
  • the outlets 58 and container 54 form the contour of a dental mirror 60. This is not intended to be limiting and the outlets 58 and contour can be formed according to any item 60 to be sterilized.
  • Such an embodiment may be advantageous for uniform treatment with microplasma 42 of the surfaces of an item 60 to be sterilized.
  • the item may be placed so that it is in line with outlets 58 of the similar shaped microplasma generating system 18, such as shown schematically in Figure 5b.
  • This type of system may also provide uniform plasma treatment of an item 60 to be sterilized, which has non-uniform surfaces.
  • the placement of the outlets 58 and shape of the system 18 may facilitate generated microplasma 42, which is equidistant from each surface and point of the item 60 being sterilized.
  • a plurality of microplasma generating systems 18 can be made wherein each microplasma generating system 18a, 18b, 18c, 18d of the plurality of the microplasma generating systems 18 is in the shape of part of the contour or surfaces of the item 60 to be sterilized.
  • the plurality of microplasma generating systems l8a, l8b, l8c, l8d may be used in combination as shown schematically in Figure 5d and may provide a similar advantage of uniform plasma treatment of an item 60 to be sterilized as described hereinabove and may provide a solution for sterilization of an item 60 with non- uniform surfaces.
  • a sterilization device 10 may include a sterilization chamber 12 shaped according to the intended load of items to be sterilized. The placement and size of the microplasma generating systems 18 may be configured according to the intended load.
  • Figure 6 shows a schematic view of a sterilization device 10 configured for sterilizing dental equipment 60. The Figure shows the non-limiting example of a device for sterilizing a dental drill bit.
  • the device includes a plurality of microplasma generating systems 18 connected by an inlet 14 to a supply of microplasma generating material.
  • the inlet 14 supplies microplasma generating material to a distribution system 80, which includes a plurality of outlets 81.
  • the outlets 81 are connected to inlets 56 of the microplasma generating systems 18.
  • microplasma generating systems 18 combined with the shape of the sterilization chamber 12 and sizing and placement of the microplasma generating material distribution system 80 facilitates a device directed to optimal microplasma sterilization of the dental equipment 60.
  • the same principle can be used for a similar device for sterilization of another type and shape of item 60.
  • the microplasma generating system 18 may be positioned in the sterilization chamber 12.
  • the sterilization chamber may be a closed chamber configured for accommodating an optimal volume of plasma within the chamber.
  • the chamber may be closed in such a way that the plasma and products thereof, which are formed in the chamber are contained for a maximum possible length of time without escaping out of the chamber.
  • a vacuum is not created in the chamber, and the chamber is at ambient pressure. Ambient pressure may facilitate a greater volume of microplasma than a vacuum system with lowered pressure.
  • Such a sterilizing system 10, wherein the at least one microplasma generating system 18 and the at least one item 60 to be sterilized are contained within the same closed sterilization chamber may facilitate optimal volume and concentration of the microplasma, resulting in optimal exposure of the at least one item 60 to the sterilizing effects of all the active species in the microplasma.
  • the microplasma generating system 18 may be attached to at least one surface 64 of the sterilization chamber 12.
  • the microplasma generating system 18 may be attached so that it is relatively flush with the surface of the sterilizing chamber 12.
  • the microplasma generating system 18 may be attached into a groove or cutout 62 of the side 64 of the chamber 12 as shown schematically in Figure 7a, to facilitate a microplasma generating system 18 flush with the wall 64 of the chamber 12.
  • the microplasma generating system 18 may be attached so that it projects out from a surface 64 of the sterilizing chamber 12 as shown schematically in Figure 7b.
  • the microplasma generating system 18 may be fixedly attached to a surface 64 of the sterilizing chamber 12.
  • Figure 7c shows one microplasma generating system 18 attached to the ceiling 24 of the sterilization chamber.
  • a plurality of microplasma generating systems 18 may be attached to a surface of the sterilizing chamber 12 as shown schematically in Figure 7d.
  • Figure 7d shows three microplasma generating systems 18 spaced apart on the top side 24 of the sterilization chamber 12.
  • One or a plurality of microplasma generating systems 18 may be attached to a plurality of sides 64 of the sterilization chamber 12 as can be seen in Figure 7e and Figure 7f.
  • the microplasma generating systems 18 may be connected to the sterilization chamber 12 in order to facilitate a microplasma generating system 18 which substantially surrounds at least one item 60 to be sterilized in the sterilization chamber 12 as shown schematically in Figure 7g.
  • Figure 7g shows two views of a cyclindrical sterilization chamber with spaced apart microplasma generating systems 18 disposed on the surface of the chamber 12 for surrounding an item 60 to be sterilized.
  • a similar arrangement of surrounding microplasma generating systems 18 may be found in a different shaped chamber 12, such as, but not limited to a square shaped chamber 12.
  • the microplasma generating system 18 may be detachably attachable to the sterilization chamber 12.
  • Figure 8a and Figure 8b show schematic views of an exemplary attachment means 70 on the microplasma generating system 18 and corresponding attachment means 72 on the surfaces of the sterilization chamber 12. Any suitable number of attachment means 70 can be used to attach the microplasma generating system 18 to the sterilization chamber.
  • Figure 8a shows a microplasma attachment system with two attachment means 70, but less than or more than two can also be used.
  • Any suitable corresponding attachment 70, 72 means can be used. Non-limiting examples include press studs, clips, sockets, screw attaching means, tabs and slots, ties and links.
  • the non-limiting example shown in Figure 8a and Figure 8b is of a plurality of tabs 70 on the microplasma generating system 18, which correspond and fit into a plurality of slots 72 on the wall 64 of the sterilization chamber.
  • the sterilizing device 10 may include one or a plurality of attachment means 72 and a user may connect any number of microplasma generating systems 18 according to need. Such a system facilitates a sterilizing device 10, which can be used to sterilize a variety of different items 60 and can be tailored according to the requirements of each use.
  • the attachment means 70 on the microplasma generating system 18 is configured so that when it is attached to the sterilization chamber 12 the microplasma generating system 18 is in electrical connection with the power source of the sterilizing device 10.
  • the sterilizing device attachment means such as slots 72 are aligned with outlets of a distribution system of the microplasma generating material.
  • the attachment of the microplasma generating system 18 to the attachment means 72 in the sterilization chamber 12 also provides attachment of an inlet in the microplasma generating system 18 to an outlet of the distribution system of the microplasma generating material 16 for supply of the microplasma generating material 16 to the microplasma generating system 18.
  • the microplasma generating system 18 may be connected to the sterilization device 10 by being suspended in any suitable way in the sterilization chamber 12.
  • a microplasma generating system 18 may be attached to hooks 72 or other suspension attachment means 72 so that the system 18 is not flush against a surface of the sterilization chamber 12, but is suspended.
  • Figure 8c shows schematically a non-limiting example of a microplasma generating system 18 attached to a hook 72 and hanging down from the ceiling of a sterilization chamber 12.
  • Figure 8d shows schematically an alternative non-limiting example, wherein a microplasma generating system 18 is attached at two points to suspension means 72 in a sterilization chamber 12 so that the microplasma generating system 18 hangs horizontally across the sterilization chamber 12.
  • the microplasma generating system 18 may be held on at least one shelf 74 in the sterilization chamber 12 as shown schematically in Figure 8e.
  • a plurality of shelves 74 in the same plane or in different planes may each hold a microplasma generating system 18 as shown schematically in Figures 8f and 8g.
  • the shelves 74 may be sized according to a microplasma generating system 18 for optimal fit.
  • the shelves 74 may include means to retain the microplasma generating system 18 on the shelf 74, such as, for example belts and raised edges.
  • the microplasma generating system 18 may be held with at least one bracket 76 as shown schematically in Figure 8h.
  • the microplasma generating system 18 may be attached to the sterilization device 10, such that it is external to the sterilization chamber 12 as shown schematically in Figure 9a.
  • the microplasma generating system 18 may be in communication with the plasma generating material 16 via an inlet 56 and may be in communication with the interior of the sterilization chamber 12, wherein the item to be sterilized 60 is located, via an outlet 58 of the microplasma generating system 18.
  • the microplasma system 18 may be fixedly attached or detachable.
  • a surface on the sterilization device 10 may include a plurality of attachment means 72 corresponding to attachment means on the microplasma generating system 70 for detachable attachment of the microplasma generating system 18 to the device 10 as shown schematically in Figure 9b.
  • Figure 9b shows the non limiting example of a microplasma generating system 18 with tab attachment means 70 corresponding to slots 72 on the sterilization device 10.
  • the microplasma generating system 18 may be connected directly to the microplasma generating material 16, such as by connection of an inlet of the microplasma generating system 18 to the outlet of the reservoir 22 containing the microplasma generating material 16.
  • the sterilizing device 10 may include a distribution means 79 featuring channels 80 for flow and distribution of the microplasma generating material 16 to at least one microplasma generating system 18 as shown schematically in Figure lOa.
  • the channels 80 may be positioned in the inside of the sterilization chamber 12 as shown schematically in Figure lOb.
  • the channels 80 may be positioned on the outside of the sterilization chamber, with outlets 81 in the channels communicating microplasma generating material 16 into the microplasma generating systems 18 in the sterilization chamber 12 as shown schematically in Figure lOc.
  • the channels 80 may be any suitable means for a separated pathway for flow of the microplasma generating material 16 in the sterilization device 10.
  • the channels 80 may be tubing or piping.
  • the channels 80 may be furcated as shown schematically in Figure lOd for delivery to multiple positions of microplasma generating systems 18 in the sterilization device 10.
  • the channels 80 may be configured so that there is a closeable opening 82 of an outlet 81 of the distribution system 79, such as a tap adjacent to a microplasma generating system 18.
  • the closeable opening 82 may be adjacent to the attachment means 72 for attaching microplasma generating systems 18 to the sterilizing device 10. This design facilitates facile connection of the microplasma generating system 18 to the sterilization device 10 and connection to the plasma generating material 16. A user can control material 16 flow into an attached microplasma generating system 18.
  • the closeable openings 82 may be opened manually or may be electronically controlled.
  • the closeable openings 82 may be configured to attach to an inlet of the microplasma generating system 18.
  • microplasma generating material 16 When the closeable opening 82 is open the microplasma generating material 16 can flow into the microplasma generating system 18.
  • the microplasma generating material 16 can flow into the microchannels of the microplasma generating system 18 to generate microplasma 42, which is expelled from the at least one outlet of the microplasma generating system 18.
  • a user can control which openings/outlets 81 of the channels to be open and which to close so that some outlets 81 may be open and some outlets 81 may be closed at the same time as schematically shown in Figure lOa.
  • microplasma generating material 16 cannot or can no longer enter the microplasma generating system 18 and microplasma 42 is not generated or is no longer generated in this microplasma generating system 18.
  • the sterilizing device 10 of the present invention may be used to sterilize any suitable item 60.
  • the sterilizing device 10 may be used to sterilize one item 60.
  • the sterilizing device 10 may be configured to sterilize more than one item 60 at the same time.
  • the sterilizing device 10 is used to sterilize medical items.
  • the at least one item 60 may be placed in the sterilizing device 10, such that it can be exposed to the formed microplasma 42 for sterilization of the at least one item 60.
  • the at least one item 60 may be placed on the floor 84 of the sterilizing chamber 12 as shown schematically in Figure l la.
  • Figure l la shows the non-limiting example of tweezers 60 on the floor 84 of a cylindrical sterilization chamber 12.
  • the at least one item 60 may be surrounded by at least one microplasma generating system 18 in order that all the surfaces of the at least one item 60 can be contacted by microplasma 40.
  • the at least one item may be placed on at least one shelf 86 as shown in Figure 1 lb.
  • the shelf 86 may be made from a gas permeable material in order that the microplasma 42 can contact the underside 88 or whichever part of the at least one item 60 is resting on the shelf 86.
  • the at least one shelf 86 may include dividers 90 for separation of more than one item 60 placed on the at least one shelf 86 as shown schematically in Figure 1 lc.
  • each item 60 of a plurality of items 60 is separated by using a plurality of shelves 86, wherein each shelf 86 is for one item 60 as shown schematically in Figure 1 ld.
  • the at least one item 60 may be placed on a tray 92 and the tray 92 may be placed on a shelf 86 in the at least one sterilizing chamber 12 as shown schematically in Figure l le.
  • the tray 92 may be made from a gas permeable material, such that it is permeable to plasma.
  • the tray 92 may have dividers 94 for separating items 90 placed on the tray 92.
  • the dividers 94 may be made from a gas permeable material.
  • the tray 92 may include a cover 96.
  • the cover 96 may be made from a material which is permeable to plasma, such as a gas permeable material.
  • Suitable non-limiting examples of gas permeable materials which can be used for the tray 92, dividers 94 and cover 96 include Tyvek or polypropylene. The material may be impermeable to bacteria.
  • the tray 92 may be removable from the sterilization device 10. Such a tray 92 may be useful for storing an item 60 that has been sterilized before use of the item 60.
  • the at least one item 60 may be held in at least one bag 98.
  • the at least one bag 98 may be made of a gas permeable material, which is permeable to plasma.
  • the at least one bag may be made from a material, which is impermeable to bacteria.
  • the at least one bag 98 may be for repeated use or may be disposable.
  • the at least one bag 98 may be washable.
  • the at least one bag 98 may be sealable.
  • the at least one bag 98 may be closed by any suitable means 100, including, but not limited to at least one of a drawstring, a press stud and a zip.
  • the at least one bag 98 may be placed on a shelf 86 as shown schematically in Figure 1 lf.
  • the at least one bag 98 may be placed on a tray, which is disposed on the shelf 86.
  • the at least one bag may be suspended in the at least one chamber 12.
  • the at least one bag 98 may be suspended from any suitable suspension means 102, such as, but not limited to by a hook positioned in the sterilization chamber 12 and a corresponding link, strap or handle 104 on the at least one bag 98 for engaging the hook 102 as shown schematically in Figure l lg.
  • the at least one bag 98 includes a drawstring 100
  • the at least one bag 98 can be suspended from the drawstring 100 attached to the hook 102.
  • a plurality of bags 98 can be suspended from a plurality of attachment means 102 in the sterilization chamber 12.
  • the at least one bag 98 may be for holding one item 60 or may be for holding a plurality of items 60.
  • the at least one bag 98 may include a plurality of bag compartments 106. Each bag compartment 106 may be for holding a separate item 60. The plurality of bag compartments 106 may provide separation of items 60 to be sterilized so that surfaces of items 60 do not touch each other facilitating all surfaces of each item 60 exposable to generated microplasma 42 for optimal sterilization. The at least one bag 98 may also be useful for storing an item 60 that has been sterilized after sterilization until use of the item 60.
  • the sterilization chamber 12 may include a plurality of compartments 12 as aforementioned and shown schematically in Figure lb. Each sub compartment l2a may be for sterilizing a different item 60. Each sub compartment l2a may include a microplasma generating system 18 as described herein in connectable contact with a microplasma generating material 16 and a power source. Each sub compartment l2a may include at least one means for holding an item 60 to be sterilized such as, but not limited to a shelf 86, a tray 92, or a bag 98 as described above. The sub compartments l2a may be fixed.
  • the sub compartments l2a may be modular and can be built by using dividers 112 in the main sterilization chamber 12 as shown schematically in Figure 12.
  • the dividers 112 may be placed in divider connection points 114 in the sterilization chamber 12.
  • the dividers 112 may include hinges and may be foldable for attachment to the device 10, in a way that when not in use they are flush with the surface of the device 10.
  • a user may manipulate the hinges to form the sub compartment l2a.
  • a user can use dividers 112 to introduce the number of chambers l2a needed according to use of the sterilization device 10.
  • the sterilization device 10 may include a control 120 as shown schematically in Figure 13.
  • the control 120 may include a switch 122 to start and stop the sterilization device 10.
  • the control 120 may include power controlling means 124.
  • the control 120 may include a timer 126 for setting the time of the sterilization cycle.
  • the control 120 may include a means for opening and closing inlets 128 for allowing microplasma generating material 16 to enter a microplasma generating system 18.
  • the means for opening and closing inlets 128 may facilitate independent control on each of a plurality of inlets.
  • the control 120 may include a screen 130 and a display 132.
  • the control 120 may include different programs of sterilization cycle 134.
  • the control 120 may include a means for raising and lowering a shelf 136 on which an item to be sterilized is placed in order for the plasma generating outlets to be equidistant from the item to be sterilized.
  • the control 120 may include a means for lowering and/or extending dividers 138 to facilitate providing sub compartments in the sterilization device.
  • FIG. l4a shows a schematic view of a combination autoclave and plasma sterilization system 200 according to an aspect of the present invention.
  • the system may include an autoclave 202, which may be any suitable autoclave for steam sterilization.
  • the autoclave 202 may include all or the main features of a steam sterilizer as known in the art.
  • the autoclave 202 may include a sterilization chamber 204, a steam supply or steam generating means 206 for supplying steam to the chamber 204 and a thermostat 208 for controlling the temperature.
  • the autoclave 202 may include a power supply 210 and electrical connections for powering the device 202.
  • the power supply may be any suitable power supply that supplies power, which may be a power of from about 1000W to about 3000W.
  • the autoclave 202 may include a control 211, which may include preset or programmable programs 212 and a timer for controlling a sterilization cycle.
  • the autoclave 202 may include a safety valve 214 and may include a vacuum system 216 to remove air in the chamber.
  • a micro plasma sterilizer 10 as herein described may include a sterilization chamber 12, a container storing microplasma generating material 22, at least one microplasma generating system 18, a microplasma distribution system 79, a control 120, a power supply 48 and a means to hold an item to be sterilized 86, 102.
  • the autoclave 202 can be adapted to include a micro plasma sterilizer 10 to result in a combination autoclave and plasma sterilization system 200.
  • the sterilization chamber 204 of the autoclave 202 is compatible and may also be used as the sterilization chamber 204 of the plasma sterilizer 10.
  • the power supply 210 of the autoclave is sufficient to provide the power for the plasma sterilizer for conversion of a microplasma generating material 16 to microplasma 42.
  • the other parts of the microplasma sterilizer may be attached to the autoclave 202.
  • the autoclave 202 may be modified to include attachment means 224 for attaching at least one microplasma generating system 18. Attachment means 224 may be any suitable attachment means as described hereinabove.
  • At least one microplasma generating system 18 can be attached to the autoclave by attachment means 226 corresponding to the attachment means 224 on the autoclave 202.
  • the at least one microplasma generating system 18 may be fixedly attached to the autoclave 18.
  • the at least one microplasma generating system 18 may be detachable.
  • the at least one microplasma generating system 18 may be connected in a suitable way so that it is in electrical connection with the power supply 210 of the autoclave.
  • the at least one microplasma generating system 18 may be attached inside the sterilization chamber 204.
  • the at least one microplasma generating system 18 may be attached outside the sterilization chamber 204.
  • the autoclave 202 may be adapted to include at least one inlet 226 for providing the plasma 42 generated from the microplasma generating systems 18 to the sterilization chamber.
  • a reservoir 22 for storing plasma generating material 16 may be attached to the autoclave 202.
  • the reservoir 22 may be a reservoir as previously described hereinabove.
  • a system for distributing the microplasma generating material to the microplasma generating systems 18 may be applied to the autoclave 202.
  • the distribution system 79 may include channels 80 through which the microplasma generating material 16 can flow.
  • the channels 80 may include outlets 81, which may be closed as previously described for Figures lOa-lOd.
  • the channels 80 may be tubing which is positioned in the autoclave 202 so that at least one inlet 230 of the channels 80 is in communication with the microplasma generating material 16 of the reservoir 22 and at least one outlet 81 of the channels 80 is in communication with inlets of the microplasma generating systems 18 as previously described herein.
  • the microplasma generating material distribution system may be affixed in a suitable way on the walls or surface of the sterilization chamber 204 of the autoclave 202.
  • the microplasma generating material distribution system 79 may be connected to the reservoir 22 and to the at least one plasma generating system 18.
  • the shelves of an autoclave 202 do not need to be made from a gas permeable material as all surfaces of an item 60 being sterilized will be heated, even if the item 60 is resting on a shelf made of a non-gas permeable material.
  • the means to hold an item 60 to be sterilized in a plasma sterilizer may be gas permeable in order that all surfaces of the item 60 can be fully exposed to the generated microplasma 42.
  • shelves 86 used in the combined autoclave and plasma sterilizer 200 may be made of gas permeable material, which is heat resistant and may replace any other shelving in the autoclave 202.
  • the positioning of shelves 86 or other suitable holding means in the combined system 200 may also differ from positioning in an autoclave 202.
  • the positioning does not significantly affect the exposure of an item to be sterilized to the heat and steam.
  • the at least one shelf or other suitable holding means 86 may be placed in order that an item 60 to be sterilized is in close proximity to the at least one plasma generating systems 18.
  • the shelves 86 may be positioned so that the at least one item 60 to be sterilized is surrounded by the plasma generating systems 18 and so that each surface of an item 60 is equidistant from the plasma generating systems 18.
  • the at least one shelf 86 may be placed in any position, which allows exposure of an item placed on the shelf to the generated microplasma and microplasma products including species resulting from breakdown or decomposition of the microplasma.
  • the control 211 of the autoclave 202 may be modified to include programs of plasma sterilization 236.
  • the control 211 may include a program to dry the sterilization chamber after a steam sterilization cycle, which may be run before a micro plasma sterilization cycle.
  • a user may use a program of a combination of steam sterilization and microplasma sterilization using this combined system 200.
  • a user may also use this system 200 to perform only one of steam sterilization and plasma sterilization.
  • the combination system 200 may include a fan which may be employed in both the steam sterilizer mode and in plasma sterilizer mode.
  • a pump used to pump steam into the autoclave 202 may be used to pump plasma generating material into the sterilization chamber 204.
  • each type of sterilization use a separate pump.
  • a system that provides both steam sterilization and microplasma sterilization 200 may be advantageous in that it can reduce the time for sterilization as compared to using just steam sterilization.
  • This system 200 may also provide a way of running a quick precautionary microplasma sterilization cycle lasting only a few minutes for items 60 which have undergone steam sterilization at an earlier time or date.
  • Such a system 200 also gives a user the flexibility to choose which type of sterilization to use.
  • This combination system 200 may be more compact, taking up less space and may be less costly than having both a separate autoclave sterilizer and a separate microplasma sterilizer.
  • an autoclave for steam sterilization or parts of an autoclave may be used to construct a microplasma sterilizer 260, which only provides plasma sterilization and does not provide steam sterilization.
  • a steam generating means 206 may be removed from the autoclave.
  • the control 211 may be modified to only provide programs and control of conditions relating to microplasma sterilization.
  • the shelving may be replaced by gas permeable shelving 86.
  • the shelving 86 may be positioned for optimal exposure of an item to be sterilized to formed micro plasma 42, such as, but not limited to in the center of a plurality of microplasma generating systems 18.
  • Microplasma generating systems 18 may be applied to the autoclave, such that they are connected to microplasma generating material and to a power supply.
  • attachment means 224 for attaching microplasma generating systems 18 may be applied to the autoclave and microplasma generating systems 18 may be connected in this way.
  • a reservoir 22 for microplasma generating material 16 may be connected to the autoclave as previously described and a distribution system 79 (80, 81, 82) for distributing the microplasma generating material 16 to the microplasma generating systems 18 may be applied as previously described.
  • the present invention provides a system for plasma sterilization 270 as shown schematically in Figure l6a, wherein the system 270 may feature connectable parts, including connectable microplasma generating systems 18, a connectable power source 48, a sterilization chamber 12 and a connectable reservoir 276 for a microplasma generating material.
  • the system 270 may include an attachable distribution means 79 for distributing microplasma generating material.
  • the resulting system 270 may include at least one sterilization chamber 12, at least one array of attached microchannels 18 configured to produce microplasma 42, a material for producing microplasma 16 connected to the microchannels 18, which may be by the connected distribution system 79 (as shown in Figure l6c) and at least one power source 48 connected to the at least one array 18.
  • the sterilization chamber 12 may include spaced apart attachment means 224 affixed on the surface of the sterilization chamber 12 for attachment of the at least one array 18.
  • the sterilization chamber 12 may include at least one chamber inlet 272 for providing microplasma generating material 16 to the microchannels 18.
  • the at least one chamber inlet 272 may be adjacent to the spaced apart attachment means 224 for facile connection and supply of the microplasma generating material 16 to an attached at least one array 18.
  • the at least one array of connected microchannels 18 configured to produce microplasma may be connectable to the sterilization chamber 12.
  • the at least one array 18 may include attachment means 226 corresponding to the chamber attachment means 224 for attaching the at least one array 18 to the sterilization chamber 12.
  • the microchannels may include spaced apart electrodes arranged to produce a microplasma from a material introduced in the microchannel when a voltage is applied as previously described.
  • the at least one array may include at least one connectable gas inlet 274 for connecting to the chamber gas inlet 272. Connection of the chamber gas inlet 272 to a gas inlet 274 of the at least one array 18 may be direct or indirect via a distribution system.
  • the at least one material for generating microplasma 16 may be connected to the system 270 by a connectable container 276 which may be attached to the sterilization chamber 12 by corresponding attachment means 278.
  • the connectable container 276 may be connected to the at least one array 18 by a distribution system 79 for the microplasma generating material.
  • the distribution system 79 which may be tubing 80 may be attachable to the container 276 and to the sterilization chamber 12 by at least one attachment means 280.
  • the distribution system may be attachable to the at least one array by detachable outlets 81.
  • the system 270 may feature electrical connection 282 for connecting at least one power source 48 to the at least one array of connected microchannels 18 for supplying the power to form microplasma 42 in the microchannels.
  • the system 270 may include instructions showing how each part connects to the system 270.
  • a user may connect the parts of the system 270.
  • the system 270 is provided to a user with the parts connected together, but a user may detach a part of the system 270 and a user may replace connectable parts of the system 270.
  • the present invention provides a method of generating microplasma.
  • FIG 17 shows a flow chart of an exemplary method of generating microplasma according to an aspect of the present invention.
  • a sterilizing device of the present invention is provided 300.
  • the sterilizing device is any suitable sterilization device as described herein.
  • the device is connected to a suitable power source 302 so that the connected power source is in electrical connection with a microplasma generating system as described herein.
  • Microplasma generating material is supplied to at least one microplasma generating system 304.
  • the microplasma generating material is any suitable material as described herein.
  • the microplasma generating material may be delivered to the microplasma generating system by direct connection or via a delivery system.
  • the microplasma generating material may be supplied to the delivery system 306.
  • the delivery system may be any suitable delivery system as described herein.
  • the delivery system may include channels, such as piping and inlets and outlets disposed in connection at one end to a container holding the microplasma generating material and at a second end connected to the microplasma generating system.
  • the delivery channels may be in communication with at least one microplasma generating system. In some embodiments the delivery channels are in communication with all the attached microplasma generating systems.
  • Outlets from the delivery channel may be connected to inlets in the microplasma generating systems.
  • the delivery channel outlets are closeable and only the outlets needed may be opened 308.
  • the outlets can be opened manually. In one non-limiting example the outlets can be opened electronically.
  • the microplasma generating material may be pumped from the container in which it is held through the outlet in the container to the delivery channels.
  • the microplasma generating material may be delivered into the delivery channel outlets 310.
  • the microplasma generating material may be delivered through the open delivery channel outlets into the microplasma generating system inlets 312.
  • the microplasma generating material may be delivered through the microplasma generating system inlets and into the microchannels of the microplasma generating system 314.
  • a voltage such as a voltage in the range of from about 300V to about 2KV, which is sufficient for forming microplasma is applied to the microchannels and microplasma is generated from the microplasma generating material in the microchannels 316.
  • the flow rate of the microplasma generating material may be controlled to facilitate optimal microplasma generation.
  • the formed microplasma is delivered out of the microplasma generating system via an outlet in the microplasma generating system 318.
  • Microplasma generation may be stopped by several steps or combination of steps 320.
  • the delivery channel outlets may be closed to stop delivery of microplasma generating material into the microplasma generating system and to stop generation of microplasma 322.
  • the power supply to the microplasma generating system may be stopped in order to stop generation of microplasma 324.
  • the microplasma may be used for any suitable purpose.
  • the microplasma as herein described may include a plurality of different substances and active species. Each substance in this microplasma soup may have a different lifetime. Each generated substance may have different properties. Some generated substances may be more effective at sterilizing than other generated substances.
  • At least some of the generated substances may be converted to at least one other substance, which may also have sterilizing properties.
  • the effect of the microplasma generated substances may be synergistic.
  • the microplasma generated substances may facilitate sterilization and disinfection by any suitable mechanism.
  • the microplasma generated substances may facilitate sterilization and disinfection by physical and chemical reaction with the microorganism, such as bacteria.
  • the photons in the UV or VUV may facilitate breaking of organic bonds of bacteria or other microorganisms to inactivate them. This may facilitate the action of other species in the microplasma such as, but not limited to ions, electrons and free radicals.
  • the present invention provides a method of sterilizing at least one item.
  • FIG. 18 shows a flow chart of an exemplary method of sterilizing at least one item according to an aspect of the present invention.
  • a microplasma sterilizer may be provided 350.
  • the microplasma sterilizer may be any sterilizer as described herein.
  • the sterilizer may be a fully assembled sterilizer.
  • the sterilizer may be connected to a power source 352.
  • a user may place the item to be sterilized on a means to hold the item 354. In one example the user may place the item on a shelf in the sterilizing chamber.
  • the door of the sterilizer may be closed.
  • a user may select a program for the sterilization cycle.
  • the user activates the sterilizer, by means such as an on switch 356.
  • the generated microplasma may be in sufficient proximity to the at least one item to contact the surfaces of the at least one item 362.
  • the generated microplasma is distributed to the at least one item 364.
  • the generated microplasma may be distributed by a means and method such as, but not limited to a spraying means, or a pump.
  • the generated microplasma reacts with microorganisms and kills them or inactivates them resulting in a sterile at least one item 366.
  • the sterilization cycle may be run for any suitable amount of time, which may be less than about fifteen minutes to result in sterilization of the at least one item being sterilized.
  • the sterilization cycle is then stopped after a time interval or when completion of sterilization is detected by suitable detection means 368.
  • suitable detection means 368 The order of the steps is not meant to be limiting and any suitable order may be used.
  • the present invention provides an additional method of sterilizing at least one item as shown schematically in Figure 19.
  • the item can be any suitable item as described herein.
  • Steps 350-362 are the same as steps 350-362 in the method described in Figure 18.
  • An additional sterilizing material may be directly applied to the sterilization chamber 370.
  • the additional sterilizing material can be any suitable material which has sterilizing properties.
  • the additional sterilizing material may be the same as one of the microplasma generated products.
  • One non-limiting example is ozone.
  • the item to be sterilized is exposed and contacted with the additional sterilizing material 372.
  • the additional sterilizing material is not applied into the microplasma generating system.
  • the item to be sterilized may be sterilized by a combination of the effects of the additional sterilizing material and the microplasma products 374.
  • the additional sterilizing material is the same as one of the microplasma products
  • a greater concentration of this product may facilitate a better sterilizing effect.
  • the present invention provides an additional method of sterilizing at least one item.
  • the item can be any suitable item as described herein.
  • Figure 20 shows a flow chart of an exemplary method of sterilizing at least one item according to an aspect of the present invention.
  • a microplasma sterilizer may be provided 380.
  • the microplasma sterilizer may include detached microplasma generating systems, which may be attached by a user before use of the sterilizer 382.
  • the microplasma generating systems may be attached, by a user connecting at least one microplasma generating system to attachment means in the sterilization chamber 384.
  • the number of microplasma generating systems and how they are spaced may be calculated by a user according to the item to be sterilized and according to the position of the attachment means in the sterilization chamber.
  • a user may attach a plurality of microplasma generating systems to the walls of the sterilization chamber such that each microplasma generating system is positioned equidistant from a surface of the item to be sterilized.
  • a user may attach inlets of the microplasma generating systems to the distribution channels of the microplasma generating material 386.
  • the attachment points in the sterilization chamber for attachment of the microplasma generating system provide attachment to the distribution system of the microplasma generating material without the need for a user to separately connect the microplasma generating system to the distribution system.
  • Formation of the microplasma may be done as described in Figure 17 and to avoid being repetitive, the steps of sterilization of at least one item 388 - 404 may be the same as steps 352 - 368 described in Figure 18.
  • the microplasma generating systems may be removed from the sterilizer 406. In some embodiments, the microplasma generating systems may be reused. In some embodiments, the microplasma generating systems may be disposable. The order of the steps is not meant to be limiting and any suitable order may be used.
  • FIG. 21 shows a flow chart of an exemplary method of sterilization using a combination steam sterilizer and microplasma sterilizer according to an aspect of the present invention.
  • a combination steam sterilizer and microplasma sterilizer as hereinabove described is provided 450.
  • the combination sterilizer is connected to a power source 452.
  • a user may select a sterilization cycle program according to a control of the device 454. Alternatively, a user may manually switch on or off each sterilization mode according to the user’s needs.
  • a user may place at least one item to be sterilized in the combination sterilizer 456.
  • the user may run a steam sterilization cycle 458.
  • a user may run a shortened steam sterilization cycle.
  • the steam sterilization cycle may be stopped 460.
  • the user may run a plasma sterilization cycle 462, such as a microplasma sterilization cycle.
  • the plasma sterilization cycle may be run immediately on stopping of the steam sterilization cycle or may be run at any suitable time after stopping of the steam sterilization cycle, according to the needs of the user.
  • the plasma sterilization cycle may be run just before use of the at least one item.
  • the order of the steps is not meant to be limiting and any suitable order may be used.
  • FIG. 22 shows a flow chart of an additional exemplary method of sterilization using a combination steam sterilizer and microplasma sterilizer according to an aspect of the present invention.
  • a combination steam sterilizer and microplasma sterilizer as hereinabove described is provided 470.
  • the combination sterilizer is connected to a power source 472.
  • a user may select a sterilization cycle program according to a control of the device 474. The user may select to use the combination sterilizer for only running a steam sterilization cycle on at least one item to be sterilized.
  • the at least one item may be placed in the combination sterilizer 476.
  • the steam sterilization cycle may be run 478.
  • the steam sterilization cycle may be stopped 480.
  • the at least one item may be left in the combination sterilizer until use of the at least one item, or may be removed from the sterilizer at any suitable time.
  • the order of the steps is not meant to be limiting and any suitable order may be used.
  • FIG. 23 shows a flow chart of a further exemplary method of sterilization using a combination steam sterilizer and microplasma sterilizer according to an aspect of the present invention.
  • a combination steam sterilizer and microplasma sterilizer as hereinabove described is provided 500.
  • the combination sterilizer is connected to a power source 502.
  • a user may select a sterilization cycle program according to a control of the device 504.
  • the user may select to use the combination sterilizer for only running a plasma sterilization cycle, such as a microplasma sterilization cycle on at least one item to be sterilized.
  • the at least one item may be placed in the combination sterilizer 506.
  • the plasma sterilization cycle may be run 508.
  • the plasma sterilization cycle may be stopped after a suitable time 510.
  • the at least one item may be left in the combination sterilizer until use of the at least one item, or may be removed from the sterilizer at any suitable time.
  • the order of the steps is not meant to be limiting and any suitable order may be used.
  • FIG. 24 shows a flow chart of an exemplary method of production of a microplasma sterilizer according to an aspect of the present invention.
  • a sterilization chamber is provided 520.
  • a container for storing microplasma generating material is attached to the sterilization chamber 522, such as, but not limited to the ceiling of the sterilization chamber.
  • a microplasma generating material distribution system is applied to the chamber 524.
  • At least one piping is connected to an outlet of the container holding the microplasma generating material 526.
  • the at least one piping may include outlets for connecting to microplasma generating systems as described herein.
  • At least one microplasma generating system may be applied to the sterilization chamber, such as to surfaces of the sterilization chamber 528.
  • the microplasma generating system may be applied such that it is in electrical connection with the power source of the sterilizer 530.
  • the microplasma generating material distribution system may be connected to each of the at least one microplasma generating systems, such as to an inlet of the microplasma generating systems 532.
  • a user places surgical tongs in a microplasma sterilizer.
  • the surgical tongs is placed on a shelf positioned at the center of a cylindrical sterilization chamber. Spaced apart along the walls of the sterilization chamber are microplasma generation systems. Each system is about 20 cm in length and is made up of arrays of microchannels as described herein.
  • the microplasma sterilizer is switched on and a voltage is applied to the microchannels, which contain oxygen that is supplied to the microchannels from a reservoir of oxygen held in a container.
  • the oxygen is converted to microplasma and the microplasma is discharged from the microchannels.
  • the expelled microplasma contacts the surfaces of the surgical tongs to sterilize them.
  • the cycle is run for ten minutes, after which the surgical tongs are sterile.
  • the sterilizer is switched off.

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Plasma & Fusion (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

La présente invention concerne un dispositif de stérilisation et un procédé d'utilisation correspondant. Le dispositif de stérilisation comprend au moins une chambre de stérilisation pour stériliser au moins un article, au moins un système de génération de microplasma pour générer un microplasma, le microplasma étant destiné à stériliser ledit au moins un article, ledit au moins un système de génération de microplasma étant relié à ladite au moins une chambre de stérilisation, et au moins un système de distribution pour distribuer un matériau de génération de microplasma au système de génération de microplasma, ledit au moins un système de distribution étant relié audit au moins un système de génération de microplasma. En outre, la présente invention concerne un procédé de génération de microplasma.
PCT/IB2019/056964 2018-09-06 2019-08-19 Stérilisateur à plasma WO2020049388A1 (fr)

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Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19806516A1 (de) * 1998-02-17 1999-08-19 Ruediger Haaga Gmbh Verfahren zum Sterilisieren von Behältern
US5980825A (en) * 1996-04-04 1999-11-09 Johnson & Johnson Medical, Inc. Method of sterilization using pretreatment with hydrogen peroxide
WO2000079843A1 (fr) * 1999-06-23 2000-12-28 Skion Corporation Appareil de traitement par gerbes de plasma produites par decharge d'electrodes capillaires
WO2002099836A1 (fr) * 2001-06-07 2002-12-12 Plasmion Corporation Appareil et procede utilisant une douche de plasma de decharge capillaire pour steriliser et desinfecter des objets
WO2009140509A1 (fr) 2008-05-14 2009-11-19 The Board Of Trustees Of The University Of Illinois Réseaux de dispositifs au plasma à microcavités et microcanaux dans une seule feuille unitaire
KR20100083975A (ko) * 2009-01-15 2010-07-23 최은경 저온 플라즈마를 이용한 고압증기 의료용 소독 멸균장치
US20120063966A1 (en) * 2010-09-07 2012-03-15 National Cheng Kung University Microplasma source and sterilization system including the same
WO2013032182A2 (fr) * 2011-08-29 2013-03-07 Park Chan Hum Appareil à microplasma commandé en parallèle pour traiter des découpes
US20150157870A1 (en) * 2013-12-09 2015-06-11 EP Technologies LLC Shape conforming flexible dielectric barrier discharge plasma generators
US20150270110A1 (en) 2013-09-24 2015-09-24 The Board Of Trustees Of The University Of Illinois Modular microplasma microchannel reactor devices, miniature reactor modules and ozone generation devices
CN106729816A (zh) * 2016-12-15 2017-05-31 合肥优亿科机电科技有限公司 一种便携式高压蒸汽灭菌锅

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5980825A (en) * 1996-04-04 1999-11-09 Johnson & Johnson Medical, Inc. Method of sterilization using pretreatment with hydrogen peroxide
DE19806516A1 (de) * 1998-02-17 1999-08-19 Ruediger Haaga Gmbh Verfahren zum Sterilisieren von Behältern
WO2000079843A1 (fr) * 1999-06-23 2000-12-28 Skion Corporation Appareil de traitement par gerbes de plasma produites par decharge d'electrodes capillaires
WO2002099836A1 (fr) * 2001-06-07 2002-12-12 Plasmion Corporation Appareil et procede utilisant une douche de plasma de decharge capillaire pour steriliser et desinfecter des objets
WO2009140509A1 (fr) 2008-05-14 2009-11-19 The Board Of Trustees Of The University Of Illinois Réseaux de dispositifs au plasma à microcavités et microcanaux dans une seule feuille unitaire
KR20100083975A (ko) * 2009-01-15 2010-07-23 최은경 저온 플라즈마를 이용한 고압증기 의료용 소독 멸균장치
US20120063966A1 (en) * 2010-09-07 2012-03-15 National Cheng Kung University Microplasma source and sterilization system including the same
WO2013032182A2 (fr) * 2011-08-29 2013-03-07 Park Chan Hum Appareil à microplasma commandé en parallèle pour traiter des découpes
US20150270110A1 (en) 2013-09-24 2015-09-24 The Board Of Trustees Of The University Of Illinois Modular microplasma microchannel reactor devices, miniature reactor modules and ozone generation devices
US20150157870A1 (en) * 2013-12-09 2015-06-11 EP Technologies LLC Shape conforming flexible dielectric barrier discharge plasma generators
CN106729816A (zh) * 2016-12-15 2017-05-31 合肥优亿科机电科技有限公司 一种便携式高压蒸汽灭菌锅

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