WO2020042020A1

WO2020042020A1 - Ultrasonic elasticity detection device and shear wave elasticity imaging method and apparatus

Info

Publication number: WO2020042020A1
Application number: PCT/CN2018/103039
Authority: WO
Inventors: 徐志安; 李双双; 董腾驹
Original assignee: 深圳迈瑞生物医疗电子股份有限公司; 深圳迈瑞科技有限公司
Priority date: 2018-08-29
Filing date: 2018-08-29
Publication date: 2020-03-05
Also published as: CN110573084B; CN110573084A

Abstract

An ultrasonic elasticity detection device and a shear wave elasticity imaging method. The method comprises: controlling an ultrasonic probe (101) to transmit an ultrasonic wave to a region of interest of a target tissue (108) for a first duration (T1), so as to detect a first shear wave passing through the region of interest, and receiving an echo of the ultrasonic wave so as to obtain a first collected sample (step 11); and obtaining a second duration (T2) according to the first collected sample (step 13); then, controlling the ultrasonic probe (101) to transmit an ultrasonic wave to the region of interest of the target tissue (108) for a second duration (T2), so as to detect a second shear wave passing through the region of interest, and receiving an echo of the ultrasonic wave so as to obtain a second collected sample (step 15); and calculating elasticity parameters of the region of interest based on multiple pieces of data in the first and second collected samples (step 18). By using the method of automatically optimizing multiple sample collection times during a sample collection process, the collection efficiency of ultrasonic elasticity detection can be improved, and the validity of shear wave elasticity imaging results are further improved.

Description

Ultrasonic elasticity detection equipment and shear wave elasticity imaging method and device

Technical field

The invention relates to an ultrasonic device, in particular to an ultrasonic elasticity detection device and a shear wave elastic imaging method.

Background technique

Shear wave elastography is an emerging tissue imaging technology. Shear wave elastography can be used to determine some mechanical characteristics of biological tissues, such as the elasticity of the tissue. Furthermore, the acquired elasticity information can assist in determining whether the target tissue is related to Certain pathological symptoms are associated, such as the auxiliary detection of cancerous lesions in tissues, benign and malignant discrimination, assessment of prognostic recovery, and the degree of fibrosis in certain tissues and organs (such as the liver).

The basic principle of shear wave elastography is to generate a shear wave in the target tissue, and at the same time, continuously emit an ultrasonic wave to the region of interest of the target tissue. The ultrasonic wave forms a scanning section in the region of interest and receives the scanning section. The ultrasonic echoes can then be subjected to specific processing on the received ultrasonic echo signals, so that various characteristic parameters of the shear wave propagating inside the target tissue can be determined, for example, the propagation speed of the shear wave. Since there is a certain relationship between the characteristic parameters of the shear wave propagating inside the target tissue and the elasticity of the target tissue, based on the determined shear wave characteristic parameters (for example, the propagation speed of the shear wave), it can assist the Target organization for analysis, diagnosis, or treatment.

According to the different methods of generating shear waves, it can be divided into a variety of different methods of shear wave elastic imaging, such as elastic imaging or elastic measurement of shear waves based on acoustic radiation force, and instantaneous elasticity of shear waves based on external vibration. Imaging. However, no matter what kind of shear-wave elastography technology, if you only rely on the shear-wave characteristic parameters obtained from a single sample collection, you may not be able to truly reflect the elasticity of the target tissue, such as the degree of liver fibrosis. Therefore, the doctor may wish to perform multiple inspections to obtain multiple collection samples of the same collection section, and calculate the shear wave characteristic parameters calculated from the multiple collection samples to reflect the elasticity of the target tissue.

In actual operation, if multiple acquisition samples of the same acquisition section are to be obtained, the doctor is required to keep the position of the probe in a stable position, that is, to keep the ultrasound emission position and angle unchanged. However, doctors are often affected by factors such as breathing, and it is difficult to keep the position of the probe in a stable position, so it is difficult to obtain multiple samples of the same section. However, the shear wave characteristic parameters (for example, shear wave propagation speed) of different cut planes may be different due to different tissue characteristics and are not statistically significant.

Summary of the Invention

The invention mainly provides an ultrasonic elasticity detection device and a shear wave elasticity imaging method, which make it easier for a doctor to obtain multiple collection samples of the same section.

According to an aspect of the present invention, a shear wave elastography method is provided, including:

Detecting the first collected sample specifically includes: controlling an ultrasound probe to emit ultrasound to a region of interest of a target tissue for a first duration to detect a first shear wave passing through the region of interest, and receiving an echo of the ultrasound to obtain a first A collection sample;

Obtaining a second duration according to the first collected sample;

Detecting the second collected sample specifically includes: controlling the ultrasound probe to transmit ultrasonic waves to the region of interest of the target tissue for a second duration to detect the second shear wave passing through the region of interest, and receiving the echo of the ultrasonic wave to obtain the first Two collection samples;

The elasticity parameter of the region of interest is calculated based on a plurality of data in the first collected sample and the second collected sample.

According to another aspect of the present invention, an ultrasonic elasticity detection device is provided, including:

A transducer for transmitting ultrasound waves to a region of interest of a target tissue and receiving echoes of the ultrasound waves;

The transmitting and receiving controller is used to control the ultrasonic probe to transmit ultrasonic waves to the region of interest of the target tissue for a first duration to detect the first shear wave passing through the region of interest, and receive the echo of the ultrasonic wave to obtain the first acquisition. For the sample, when the second duration is obtained, the ultrasound probe is controlled to transmit ultrasonic waves to the region of interest of the target tissue for the second duration to detect the second shear wave passing through the region of interest, and receive the echo of the ultrasonic wave to obtain the first Two collection samples;

The data processor is configured to obtain a second duration according to the first collected sample, and calculate an elasticity parameter of the region of interest based on a plurality of data in the first collected sample and the second collected sample.

According to another aspect of the present invention, there is provided a computer-readable storage medium including a program that can be executed by a processor to implement the method as described above.

According to another aspect of the present invention, a shear wave elastic imaging device is provided, including:

The first sample acquisition detection unit is configured to control the ultrasonic probe to transmit ultrasonic waves to the region of interest of the target tissue for a first duration to detect the first shear wave passing through the region of interest, and receive the echo of the ultrasonic wave to obtain the first A collection sample;

A second duration obtaining unit, configured to obtain a second duration according to the first collected sample;

The second sample acquisition detection unit is configured to control the ultrasound probe to transmit ultrasonic waves to the region of interest of the target tissue for a second period of time to detect the second shear wave passing through the region of interest, and receive the echo of the ultrasonic wave to obtain the first Two collection samples;

An elasticity parameter calculating unit is configured to calculate an elasticity parameter of a region of interest based on a plurality of data in the first and second collected samples.

According to the ultrasonic elasticity detection device and the shear wave elastic imaging method of the above embodiment, the time of multiple sample acquisition during the sample collection process is automatically optimized to improve the collection efficiency of the ultrasonic elasticity detection, thereby improving the result of the shear wave elasticity imaging. Effectiveness.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a schematic structural diagram of an ultrasonic elasticity detection device;

FIG. 2 is a schematic diagram of a propagation path of a shear wave in vivo; FIG.

FIG. 3 is a schematic diagram of a process of automatically optimizing the entire sampling time;

4 is a flowchart of a process for performing elasticity detection on biological tissue in an embodiment;

FIG. 5 is a schematic diagram of obtaining a second duration T2 according to a propagation path diagram of shear waves in biological tissues according to an embodiment.

detailed description

The present invention will be further described in detail below through specific embodiments in combination with the accompanying drawings. In the different embodiments, similar elements are labeled with associated similar elements. In the following embodiments, many details are described so that the present application can be better understood. However, those skilled in the art can effortlessly realize that some of these features can be omitted in different situations, or can be replaced by other elements, materials, and methods. In some cases, some operations related to this application are not shown or described in the description. This is to prevent the core part of this application from being overwhelmed by excessive descriptions. For those skilled in the art, detailed description of these operations The related operations are not necessary, they can fully understand the related operations according to the description in the description and the general technical knowledge in the field.

In addition, the features, operations, or features described in the specification can be combined in any suitable manner to form various embodiments. At the same time, the steps or actions in the method description can also be sequentially swapped or adjusted in a manner obvious to those skilled in the art. Therefore, the various orders in the description and drawings are only for clearly describing a certain embodiment, and are not meant to be a necessary order, unless otherwise stated that a certain order must be followed.

The serial numbers of components in this article, such as "first", "second", etc., are only used to distinguish the described objects and do not have any order or technical meaning. The terms “connection” and “connection” in this application include direct and indirect connections (connections) unless otherwise specified.

Please refer to FIG. 1. The structure of the ultrasonic elasticity detection device 100 is shown in FIG. 1 and includes an ultrasonic probe 101, a transmitting and receiving controller 102, a data processor 105, a display device 106, and a memory 107. In a specific embodiment, the ultrasonic elasticity detection device 100 further includes a transmitting and receiving circuit 103 and an echo signal processor 104. The transmitting and receiving controller 102 is signal-connected to the ultrasonic probe 101 through the transmitting and receiving circuit 103, and the ultrasonic probe 101 is connected to the ultrasonic probe 101 through the transmitting and receiving circuit. 103 is signally connected to the echo signal processor 104, the output terminal of the echo signal processor 104 is connected to the data processor 105, and the output terminal of the data processor 105 is connected to the display device 106. The memory 107 is connected to the data processor 105.

The ultrasound probe 101 includes a plurality of transducers, which are also called array elements, and are used to realize the mutual conversion of electrical pulse signals and ultrasonic waves, so as to achieve the detection of biological tissues (such as biological tissues in the human body or animal body) 108 Transmits ultrasound waves and receives ultrasound echoes reflected back from the tissue. Multiple transducers can be arranged in a row to form a linear array, or arranged in a two-dimensional matrix to form an area array, and multiple transducers can also form a convex array. The transducer can transmit ultrasonic waves according to the excited electrical signals, or transform the received ultrasonic waves into electrical signals. Therefore, each transducer can be used to transmit ultrasonic waves to biological tissues in the region of interest, and can also be used to receive ultrasonic echoes returned by the tissue. When performing ultrasonic testing, it is possible to control which transducers are used to transmit ultrasonic waves, which transducers are used to receive ultrasonic waves, or to control the transducers to be used to transmit ultrasonic waves or receive ultrasonic echoes by transmitting and receiving sequences. All transducers participating in ultrasonic emission can be simultaneously excited by electrical signals, thereby transmitting ultrasonic waves simultaneously; or the transducers participating in ultrasonic emission can also be excited by several electrical signals with a certain time interval, thereby continuously transmitting ultrasonic waves with a certain time interval .

The transmitting and receiving controller 102 is configured to generate a transmitting sequence and output the transmitting sequence to an ultrasound probe. The transmitting sequence is used to control part or all of multiple array elements to transmit ultrasonic waves to biological tissues in a region of interest. The transmitting sequence also provides transmitting parameters ( For example, the amplitude, frequency, number of waves, wave angle, wave shape and / or focus position of the ultrasonic wave, etc.). According to different purposes, the wave pattern, transmission direction and focus position of the transmitted ultrasound can be controlled by adjusting the transmission parameters. The wave pattern of the ultrasound can be pulsed ultrasound, plane wave, etc.

The transmitting and receiving circuit 103 is connected between the ultrasonic probe and the transmitting and receiving controller 102 and the echo signal processor 104, and is used for transmitting the transmitting sequence of the transmitting and receiving controller 102 to the ultrasonic probe 101 and transmitting the ultrasound received by the ultrasonic probe 101. The echo signal is transmitted to the echo signal processor 104.

The echo signal processor 104 is configured to process an ultrasonic echo signal, for example, perform processing such as filtering, amplification, and beam combining on the ultrasonic echo signal to obtain ultrasonic echo data. In a specific embodiment, the echo signal processor 104 may output the ultrasonic echo data to the data processor 105, or may store the ultrasonic echo data in the memory 107 first. When a calculation is required based on the ultrasonic echo data, The data processor 105 reads the ultrasonic echo data from the memory 107.

The memory 107 is used to store data and programs, and the programs may include a system program of an ultrasound device, various application programs, or algorithms that implement various specific functions.

The data processor 105 is configured to acquire ultrasonic echo data and obtain relevant parameters or images by using a related algorithm.

The data processor 105 may generate an ultrasonic image according to the ultrasonic echo data, or obtain elastic modulus data according to the ultrasonic echo data to generate a shear wave elastic image.

In order to generate a shear wave in the tissue, in one embodiment, the ultrasound probe 101 further includes a vibrator, and the vibrator may be disposed in the housing of the probe or outside the housing. The vibrator vibrates according to a predetermined frequency, and the tissue on the traction surface vibrates with it, and uses the adhesion between the tissues to generate a shear wave propagating deep into the tissue. In another embodiment, the ultrasound probe 101 promotes tissue movement by transmitting ultrasound waves, and uses adhesion between the tissues to generate a shear wave that propagates within the tissue.

However, no matter which method is used to generate the shear wave, when detecting the shear wave, the ultrasonic probe needs to continuously emit ultrasonic waves for a period of time and receive echoes of the ultrasonic waves. This period of time is referred to as the ultrasonic detection time.

During the research and development of the present invention, the inventors found that due to the influence of individual case differences, the shear wave propagation speed of patients with different degrees of fibrosis is different, and the depth of the sampling frame is also different. The entire propagation path of the shear wave can be collected, and the ultrasonic detection time is usually set longer. Figure 2 is a schematic diagram of the propagation path of the shear wave in the body. The shear waves w1 and w2 propagate from the depth h1 to h2 at the speeds v1 and v2, respectively. The shear wave w1 needs time t1 and the shear wave w2 needs time t2, when v1> v2, t1 <t2. However, in order to ensure that the entire propagation path of the shear wave of different individuals is collected, the ultrasonic detection time is generally set to T1, and T1> t1, T1> t2. When it is necessary to obtain n collection samples of the same acquisition section, an ultrasonic probe is required to first generate a shear wave on a certain section selected by the user, and then transmit an ultrasonic wave of T1 duration to detect the shear wave. This process is referred to herein as One sample test. After detecting the first collected sample, control the ultrasound probe to generate a second shear wave on the same slice selected by the user, and then emit an ultrasonic wave of T1 duration to detect the second shear wave to obtain a second collected sample. , And so on, to obtain n collection samples, the whole process time is n (Tx + T1). Because the entire test takes a long time, it is difficult for the doctor to keep the operation posture unchanged during this process. Therefore, the inventors realized that if the ultrasonic detection time is set according to the time required by each individual, the time of the entire process can be reduced, and the shorter the time, the easier it is for the doctor to keep the operating posture unchanged, so that the ultrasound can be maintained The position and angle of the probe transmitting ultrasonic waves are not changed, that is, it is ensured that the n collection samples collected are data of the same collection section.

Based on the above ideas, the concept of the present invention is shown in FIG. 3: first generate a shear wave in the tissue, and use the default ultrasonic emission duration T1 (that is, the first duration) to detect the shear wave and receive the ultrasonic wave. The echo is used to obtain the first collected sample, and the second duration T2 is obtained according to the first collected sample. The subsequent n-1 shear waves are detected using the second duration T2. Therefore, the entire detection process takes nTx + T1 + ( n-1) T2, when T2 <T1, T1 + (n-1) T2 <nT1, thereby reducing the measurement time of the entire process.

For the convenience of description, the shear wave detected using the first time T1 is referred to as the first shear wave, and the shear wave detected using the second time T2 is referred to as the second shear wave. The detection process is performed on the same object. In the method, it takes the same time to transmit the first shear wave and the second shear wave, and the transmission mode and transmission parameters are the same.

There may be multiple schemes for obtaining the second duration T2 according to the first collected sample, which are described separately below.

In one embodiment, the elasticity detection process of biological tissue is described in a manner of generating a shear wave by vibration, please refer to FIG. 4.

Step 10: Generate a first shear wave. The ultrasonic probe 101 is provided with a vibrator. The vibrator can generate low-frequency vibrations. When the vibrator contacts the surface of a living body, a first shear wave propagating inward in the living body can be generated, and the shear wave will pass through the region of interest.

Step 11: Transmit an ultrasonic wave of a first duration T1 and receive an echo. The ultrasonic probe 101 is in stable contact with the surface of the biological body 108, and the ultrasonic wave is transmitted to the region of interest according to the set transmission parameters (such as the set amplitude, frequency, and transmission angle, etc.), and the first duration T1 is maintained, so that the sense of passage The first shear wave of the region of interest is detected. During the process of transmitting ultrasonic waves, echoes of ultrasonic waves are continuously received. For the convenience of explanation, the echo of the ultrasonic wave received for the first duration T1 is referred to as the first sample.

Step 12: Calculate a propagation velocity of the first shear wave according to the first collected sample. The echo signal processor 104 processes the ultrasonic echo signal of the first collected sample, and the data processor 105 performs correlation calculation on the processed data to obtain the displacement of the first shear wave in the tissue. To obtain the propagation velocity of the first shear wave.

Step 13: Determine the second duration according to the propagation speed of the first shear wave. When the depth of the region of interest and the propagation speed of the first shear wave are known, the time it takes for the first shear wave to reach the bottom of the region of interest can be calculated, for example, the depth of the region of interest divided by the first shear wave The propagation velocity of the shear wave can be calculated as the time it takes for the shear wave to reach the bottom of the region of interest. The second duration T2 is determined according to the time. For example, the second duration T2 may be equal to or slightly longer than the time when the shear wave reaches the bottom of the region of interest. Generally, T2 <T1.

Step 14. Generate a second shear wave. A second shear wave can be generated in the same manner as in step 10.

Step 15: Transmit an ultrasonic wave of a second duration T2 and receive an echo. Use the same position and the same transmission parameters as in step 11 to transmit ultrasonic waves to the region of interest for a second duration T2, so as to detect the second shear wave passing through the region of interest. Similarly, during the process of transmitting ultrasonic waves, echoes of ultrasonic waves are continuously received. For the convenience of explanation, the echo of the ultrasonic wave received for the second duration T2 is referred to as the second sample.

Step 16. Calculate the propagation speed of the second shear wave according to the second collected sample.

Step 17. Determine whether the collected samples are sufficient. When it is determined that the collected samples are sufficient, go to step 18; otherwise, go to step 14 and execute steps 14 to 16 to obtain more collected samples.

Step 18: Calculate the elasticity parameter of the region of interest according to the propagation speed obtained from the multiple collected samples. The elasticity parameter is used to evaluate the elasticity of the tissue, which can be the propagation speed of the shear wave or the Young's modulus. When the elastic parameter is the propagation velocity of the shear wave, the propagation velocity obtained from multiple collected samples can be averaged, and the average value can be used as the propagation velocity of the shear wave traveling through the region of interest. The larger the propagation velocity, the region of interest is represented. The greater the flexibility.

When the elastic parameter is the elastic modulus, the following relationship exists between the propagation velocity of the shear wave and the elastic modulus of the tissue:

Among them, formula (1) is also called Young's modulus, where E represents the elastic modulus of the region of interest of the biological tissue to be detected, ρ represents the density of the region of interest of the biological tissue to be detected, and C _s represents emission to Detect the shear wave propagation velocity of a region of interest in a biological tissue.

After calculating the average value of the propagation velocity of the shear wave traveling through the region of interest, the average value is taken into formula (1) to calculate the Young's modulus. In another embodiment, the Young's modulus may also be calculated according to the propagation velocity obtained by each collected sample, and then multiple Young's moduli may be averaged.

In this embodiment, when the position and posture of the doctor holding the ultrasound probe remain unchanged, the ultrasound scanning section formed in step 15 and the ultrasound scanning section in step 11 are the same scanning section. Since T2 is less than or equal to T1, this embodiment reduces the measurement time compared to the scheme that uses the first duration T1 to transmit ultrasound, so that the doctor can complete the test in a shorter time, and reduces the chance that the doctor changes the position and posture of the probe. , Which can ultimately help improve the accuracy of the test results.

In some examples, the detection ultrasonic wave is transmitted at the same time as the shear wave is transmitted. Since the time to transmit the shear wave is shorter than the time to transmit the detection ultrasonic wave, the time required to obtain a sample is T1, which is obtained after the above steps 10-13. The second duration T2 is still less than or equal to T1, so the doctor's measurement time can also be reduced.

In one embodiment, the second time period T2 may be determined by using a method different from the foregoing embodiment.

In this embodiment, the ultrasonic elasticity detection device 100 transmits an ultrasonic wave of a first duration T1 and receives an echo, wherein the biological tissue of the region of interest traveled by the first shear wave is shown as a rectangular frame region in a fan-shaped image on the left in FIG. 5. As shown, the image display area on the right in FIG. 5 shows a propagation path diagram of the corresponding first shear wave in the biological tissue. The echo signal processor 104 processes the ultrasonic echo signal of the first collected sample, and the data processor 105 performs correlation calculation on the processed data to obtain a propagation path diagram of the first shear wave in the biological tissue, as shown in the figure. The white dotted line in the right image in 5 is shown. When the propagation path of the first shear wave is known, by calculating the time interval between the start and end points of the first shear wave, the time when the first shear wave reaches the bottom of the region of interest can be obtained. The ultrasonic elasticity detection device 100 determines the second time period T2 according to the first shear wave time parameter calculated above, and uses the second time period T2 for the elasticity detection process of the biological tissue, so that the doctor can complete the detection in a shorter time.

In the above embodiment, the ultrasonic probe 101 generates a shear wave by using a low-frequency vibration signal method. In other embodiments, the ultrasonic probe 101 may also use other methods in the prior art (such as a method of acoustic radiation) to detect the organism. The region of interest of the tissue 108 emits a shear wave.

In the above embodiment, the first collection sample used to determine the second duration is not limited to transmitting and receiving a shear wave signal and detection data obtained by corresponding ultrasonic signals, and may also be a method of transmitting and receiving multiple shear wave signals and corresponding The calculation result of the detection data obtained by the ultrasonic signal; similarly, the second collected sample is not limited to transmitting and receiving the shear wave signal and the detection data obtained by the corresponding ultrasonic signal, but may also be the transmission and reception of the multiple shear wave signal and the corresponding Calculation results of the detection data obtained from the ultrasonic signals. That is, there may be multiple first collected samples or multiple second collected samples. That is, the elasticity parameter of the region of interest can be calculated based on the multiple data of the first collected sample and the second collected sample. There can be multiple data source combinations for calculation. For example, the second duration is obtained by collecting the sample data for the first time, and the second collection sample data is obtained based on the second duration data. The elasticity parameter is obtained by calculating the data of the collected sample twice; One sample data is collected to obtain the second duration, and the second time sample data is used to obtain the second collected sample data. The elasticity parameter is obtained by calculating the multiple times of the collected sample data. The first parameter data may also be used to obtain the first time. Two durations, according to the second duration data, multiple second collection sample data is obtained, and the elasticity parameter is obtained by calculating the multiple collection data of the sample; the second duration may also be obtained through multiple first collection sample data, according to The data of the second duration is obtained a plurality of times of the second collected sample data, and the elasticity parameters are obtained by calculating the times of the collected data of the samples. The multiple collection samples are selected from the first collection sample and the second collection sample.

Those skilled in the art may understand that all or part of the functions of the various methods in the foregoing embodiments may be implemented by hardware, or by computer programs. When all or part of the functions in the foregoing embodiments are implemented by means of a computer program, the program may be stored in a computer-readable storage medium. The storage medium may include: a read-only memory, a random access memory, a magnetic disk, an optical disk, a hard disk, etc. The computer executes the program to realize the above functions. For example, the program is stored in the memory of the device, and when the processor executes the program in the memory, all or part of the functions described above can be implemented. In addition, when all or part of the functions in the above embodiments are implemented by a computer program, the program may also be stored in a storage medium such as a server, another computer, a magnetic disk, an optical disk, a flash disk, or a mobile hard disk, and saved by downloading or copying. To the memory of the local device, or to update the system of the local device, when the program in the memory is executed by the processor, all or part of the functions in the foregoing embodiments can be implemented.

Reference is made herein to various exemplary embodiments. However, those skilled in the art will recognize that changes and modifications may be made to the exemplary embodiments without departing from the scope of this document. For example, various operating steps and components for performing the operating steps can be implemented differently depending on the particular application or considering any number of cost functions associated with the operation of the system (e.g., one or more steps can be deleted, Modify or incorporate into other steps).

In addition, as understood by those skilled in the art, the principles herein may be reflected in a computer program product on a computer-readable storage medium, which is pre-loaded with computer-readable program code. Any tangible, non-transitory computer-readable storage medium can be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD-ROM, DVD, Blu Ray, etc.), flash memory, and / or the like . These computer program instructions can be loaded on a general-purpose computer, special-purpose computer, or other programmable data processing device to form a machine, so that these instructions executed on the computer or other programmable data processing device can generate a device that implements a specified function. These computer program instructions can also be stored in a computer-readable memory, which can instruct a computer or other programmable data processing device to operate in a specific manner, so that the instructions stored in the computer-readable memory can form one piece Articles of manufacture, including implements that implement specified functions. Computer program instructions can also be loaded onto a computer or other programmable data processing device, thereby performing a series of operating steps on the computer or other programmable device to produce a computer-implemented process, which makes the computer or other programmable device execute Instructions can provide steps for implementing specified functions.

Although the principles herein have been shown in various embodiments, many modifications of structures, arrangements, proportions, elements, materials, and components that are particularly suitable for specific environmental and operational requirements may be made without departing from the principles and scope of this disclosure. use. The above modifications and other changes or modifications will be included within the scope of this article.

The foregoing detailed description has been described with reference to various embodiments. However, those skilled in the art will recognize that various modifications and changes may be made without departing from the scope of the present disclosure. Accordingly, the consideration of this disclosure will be in an illustrative rather than a restrictive sense, and all such modifications are intended to be included within its scope. Also, there are solutions to the advantages, other advantages, and problems of the various embodiments as described above. However, benefits, advantages, solutions to problems, and any elements that produce or make them more explicit should not be interpreted as critical, required, or necessary. As used herein, the term "including" and any other variations thereof are non-exclusive inclusions, such that a process, method, article, or device that includes a list of elements includes not only those elements but also those that are not explicitly listed or are not part of the process , Method, system, article, or other element of equipment. Furthermore, the term "coupled" and any other variations thereof as used herein refers to a physical connection, an electrical connection, a magnetic connection, an optical connection, a communication connection, a functional connection, and / or any other connection.

Those skilled in the art will recognize that many changes can be made to the details of the above-described embodiments without departing from the basic principles of the invention. Accordingly, the scope of the invention should be determined only by the following claims.

Claims

A shear wave elastography method includes:

Detecting the first collected sample specifically includes: controlling an ultrasound probe to emit ultrasound to a region of interest of a target tissue for a first duration to detect a first shear wave passing through the region of interest, and receiving an echo of the ultrasound to obtain a first A collection sample;

Obtaining a second duration according to the first collected sample;

Detecting the second collected sample specifically includes: controlling the ultrasound probe to transmit ultrasonic waves to the region of interest of the target tissue for a second duration to detect the second shear wave passing through the region of interest, and receiving the echo of the ultrasonic wave to obtain the first Two collection samples;

The elasticity parameter of the region of interest is calculated based on a plurality of data in the first collected sample and the second collected sample.
The method according to claim 1, wherein the obtaining the second duration according to the first collected sample comprises:

Calculating the speed of the first shear wave according to the first collected sample;

Calculating the time when the shear wave reaches the bottom of the region of interest according to the depth of the region of interest and the speed of the first shear wave;

Determine the second duration based on time.
The method according to claim 1, wherein the obtaining the second duration according to the first collected sample comprises:

Generating a shear wave propagation path map according to the first collected sample;

The time taken for the shear wave to reach the bottom of the region of interest is obtained according to the shear wave propagation path diagram, and the second time is determined based on the time.
The method according to claim 1, wherein there are a plurality of first collected samples, and the second duration is obtained according to the plurality of first collected samples.
The method according to claim 1, wherein there are a plurality of second collection samples.
An ultrasonic elasticity detection device, comprising:

A transducer for transmitting ultrasound waves to a region of interest of a target tissue and receiving echoes of the ultrasound waves;

The transmitting and receiving controller is used to control the ultrasonic probe to transmit ultrasonic waves to the region of interest of the target tissue for a first duration to detect the first shear wave passing through the region of interest, and receive the echo of the ultrasonic wave to obtain the first acquisition. For the sample, when the second duration is obtained, the ultrasound probe is controlled to transmit ultrasonic waves to the region of interest of the target tissue for the second duration to detect the second shear wave passing through the region of interest, and receive the echo of the ultrasonic wave to obtain the first Two collection samples;

The data processor is configured to obtain a second duration according to the first collected sample, and calculate an elasticity parameter of the region of interest based on a plurality of data in the first collected sample and the second collected sample.
The ultrasonic elasticity testing device according to claim 6, wherein the obtaining, by the data processor, the second duration according to the first collected sample comprises:

Calculating the speed of the first shear wave according to the first collected sample;

Calculating the time when the shear wave reaches the bottom of the region of interest according to the depth of the region of interest and the speed of the first shear wave;

Determine the second duration based on time.
The ultrasonic elasticity testing device according to claim 6, wherein the obtaining, by the data processor, the second duration according to the first collected sample comprises:

Generating a shear wave propagation path map according to the first collected sample;

The time taken for the shear wave to reach the bottom of the region of interest is obtained according to the shear wave propagation path diagram, and the second time is determined based on the time.
The ultrasonic elasticity detection device according to claim 6, wherein there are a plurality of first collected samples, and the second duration is obtained based on the plurality of first collected samples.
The ultrasonic elasticity detection device according to claim 6, wherein there are a plurality of second collection samples.
A computer-readable storage medium, comprising a program, which can be executed by a processor to implement the method according to any one of claims 1-5.
A shear-wave elastography device includes:

The first sample acquisition detection unit is configured to control the ultrasonic probe to transmit ultrasonic waves to the region of interest of the target tissue for a first duration to detect the first shear wave passing through the region of interest, and receive the echo of the ultrasonic wave to obtain the first A collection sample;

A second duration obtaining unit, configured to obtain a second duration according to the first collected sample;

The second sample acquisition detection unit is configured to control the ultrasound probe to transmit ultrasonic waves to the region of interest of the target tissue for a second period of time to detect the second shear wave passing through the region of interest, and receive the echo of the ultrasonic wave to obtain Two collection samples;

An elasticity parameter calculating unit is configured to calculate an elasticity parameter of a region of interest based on a plurality of data in the first and second collected samples.
The device according to claim 12, further comprising: the second duration obtaining unit is configured to calculate a speed of the first shear wave according to the first collected sample, and according to the depth of the region of interest and the first shear wave The velocity calculates the time it takes for the shear wave to reach the bottom of the region of interest, and the second duration is determined based on this time.
The apparatus according to claim 12, further comprising: the second duration obtaining unit is configured to generate a shear wave propagation path map according to the first collected sample, generate a shear wave propagation path map according to the first collected sample, and The shear wave propagation path map is used to obtain the time when the shear wave reaches the bottom of the region of interest, and the second time is determined according to the time.
The device according to claim 12, further comprising: a plurality of first collected samples, and the second duration obtained according to the plurality of first collected samples.
The apparatus according to claim 12, further comprising: a plurality of second collection samples.