WO2020020539A1 - Composition antipelliculaire - Google Patents

Composition antipelliculaire Download PDF

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Publication number
WO2020020539A1
WO2020020539A1 PCT/EP2019/066070 EP2019066070W WO2020020539A1 WO 2020020539 A1 WO2020020539 A1 WO 2020020539A1 EP 2019066070 W EP2019066070 W EP 2019066070W WO 2020020539 A1 WO2020020539 A1 WO 2020020539A1
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WO
WIPO (PCT)
Prior art keywords
composition
oil
dry weight
additionally
weight basis
Prior art date
Application number
PCT/EP2019/066070
Other languages
English (en)
Inventor
Neesha BARCHHA
Dolly Himanshu Desai
Manish Gangopadhyay
Sowmiya RAJAGOPALAN
Pooja Shankardas SERAI
Godfrey Serrao
Original Assignee
Unilever N.V.
Unilever Plc
Conopco, Inc., D/B/A Unilever
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever N.V., Unilever Plc, Conopco, Inc., D/B/A Unilever filed Critical Unilever N.V.
Publication of WO2020020539A1 publication Critical patent/WO2020020539A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations

Definitions

  • This invention relates to an antidandruff shampoo composition.
  • the invention more particularly relates to a shampoo composition that comprises combination of natural actives that delivers the desired anti-dandruff benefits.
  • the invention relates to a shampoo composition that provides desired antidandruff benefits in addition to cleansing of hair and scalp.
  • Hair care compositions generally provide cleansing or conditioning benefits or a combination of the two.
  • Such compositions typically comprise one or more cleansing surfactants which generally aid in cleaning the hair and/or the scalp free of undesirable soil, particles, and fatty matter.
  • anti-dandruff benefit has been provided through hair care compositions.
  • Dandruff is an issue that affects many people globally. The condition is manifested by the shedding of clumps of dead skin cells from the scalp. These are white in colour and provide an aesthetically displeasing appearance.
  • a factor that contributes to dandruff are certain members of the Malassezia yeasts.
  • anti-dandruff products have been developed in the form of hair cleansing shampoos.
  • An example of a known anti-dandruff shampoo comprises sodium lauryl ether sulfate (an ethoxylated anionic surfactant) in combination with an anti-dandruff agent.
  • Typical anti-dandruff agents used in hair care are metal pyrithione e.g., zinc pyrithione (ZPTO), Octopirox (piroctone olamine), azole antimicrobials, selenium sulfide and combinations thereof.
  • ZPTO zinc pyrithione
  • Octopirox piroctone olamine
  • azole antimicrobials selenium sulfide and combinations thereof.
  • the present inventors have experimented with a large number of natural actives some of which have been known for hair care benefit including anti-dandruff benefit to come up with combination of actives that match the performance of ZPTO in providing anti- dandruff activity. They finally hit up on a combination of oil extracted from palmarosa (which has the botanical name Cymbopogon martyinii) along with extracts from herbs like neem ( Azhadirachta indica) and amla ( Phyllanthus emblica) which has been found by way of the present invention to interact synergistically to provide anti- malassezia activity on par with that obtained with ZPTO.
  • palmarosa which has the botanical name Cymbopogon martyinii
  • extracts from herbs like neem Azhadirachta indica
  • amla Phyllanthus emblica
  • WO2010086717 A1 Himalaya
  • the composition comprises extracts of organically certified herbs and polyglucosides wherein the extract is prepared employing a super critical fluid extraction or water extraction process.
  • the herbs are selected from a long list of which Phyllanthus emblica, Azhadirachta indica, Cymbopogon flexuous are three.
  • the invention therein does not clearly and unambiguously disclose the combination of palmarosa oil and an additional herb as claimed in the present invention for anti- malassezia activity.
  • US2005/191267 A1 discloses a process for obtaining high quality Mulberry extract for use in cosmetics to provide whitening effects for darkened skin through anti-tyrosinase activity, and antioxidant and anti-inflammatory properties.
  • an antidandruff shampoo composition comprising 0.1 to 5% palmarosa ( Cymbopogon martyinii) oil and 0.1 to 5% on dry weight basis of aqueous extract of one or more of Azadirachta indica or Phyllanthus emblica, wherein the composition comprises aqueous extracts of Azadirachta indica and Phyllanthus emblica.
  • Another aspect relates to a method of providing anti dandruff benefit to scalp comprising applying a composition of the first aspect on to scalp and optionally followed by rinsing the surface with water.
  • compositions for topical application to skin, hair and/or scalp of mammals, especially humans. Such a composition is generally applied on to the desired topical surface of the body and then preferably rinsed off, in a few minutes thereafter.
  • the composition of the present invention can be in the form of a liquid, lotion, cream, foam, scrub, gel, or bar. Non-limiting examples of such compositions include wash-off shampoos, shampoo- cum-conditioners, shower gels, hair care liquids gels and bars.
  • the composition of the present invention is most preferably a shampoo in the conventional lotion or semi-liquid form.
  • the present invention relates to an antidandruff cleansing composition. It provides synergistic anti-fungal action of palmarosa oil which is also known Cymbopogon martyinii along with an aqueous extract of Azadirachta indica and Phyllanthus emblica.
  • Palmarosa oil is extracted from the leaves of palmarosa. It is a tropical plant which grows in warm and humid climate. It grows wild in the central and southern part of India. It is an aromatic grass that grows all year around. It is also cultivated in areas which have warm climate and has heavy rainfall. In India, it is cultivated in the states of Karnataka, Maharashtra and Tamil Pradesh.
  • Palmarosa has been widely used in Ayurvedic skin care as a cellular stimulator and for supporting cell regulation. Other uses include uses as an antiseptic, for treating nerve pain, fever, and certain infectious diseases. It is also known for digestive properties.
  • oil of palmarosa has been used in perfumery, particularly for blending of soaps due to the lasting rose-note. It predominantly contains geraniol which is known to be stable in contact with alkali.
  • the palmarosa oil for use in the present invention was analysed by GC and found to have the following constitution: Geraniol 80% to 82%; Geranyl Acetate 8% to 10%; Ocimene 2-3%; and linalool 2-3%.
  • Palmarosa oil for use in the present invention is prepared by steam distillation of palmarosa leaves followed by collection of the distillate which is then cooled. The oil phase is then separated from the water phase to prepare the palmarosa oil.
  • Palmarosa oil is included in the shampoo composition of the present invention in 0.1 to 5%, preferably 0.5 to 2.0%, furthermore preferably 0.8 to 1.2% by weight of the composition.
  • composition of the invention also includes 0.1 to 5% on dry weight basis of aqueous extract of one or more of Azadirachta indica or Phyllanthus emblica.
  • Azadirachta indica is known in India as neem and is well known to have very good antimicrobial properties.
  • the extract of Azadirachta indica for use in the present invention is prepared from aqueous extract of the leaves of the plant. It has been sourced as a powder for use in the present invention from Chemiloids, India.
  • the extract of Azadirachta indica is preferably included in the composition on a dry weight basis at 0.1 to 3%, more preferably from 0.1 to 2% by weight of the composition.
  • Phyllanthus emblica is known in India as amla and the fruit of this plant is consumed as food.
  • the extract of Phyllanthus emblica for use in the present invention is prepared from aqueous extract of the fruits of the plant. It has been sourced as a powder for use in the present invention from Chemiloids, India.
  • the extract of Phyllanthus emblica in the composition is preferably included on a dry weight basis at 0.01 to 2%, more preferably 0.05 to 2%, furthermore preferably 0.1 to 2% by weight of the composition.
  • composition of the invention comprises extracts of both Azadirachta indica and Phyllanthus emblica. When both extracts are included they are present in 0.5 to 3%, preferably 0.5 to 2% by weight of the composition.
  • the composition of the invention may optionally additionally include extract of Rosmarinus officinalis, also known as Rosemary oil. It is an essential oil which is extracted from the leaf of the rosemary plant. The oil is generally known for its anti- microbial properties and therefore the present inventors were surprised that when high amounts of this oil was included in the shampoo composition, the odour characteristics was rendered pleasing and acceptable in spite of the inclusion of high amount of other natural extracts which do not have an acceptable odour.
  • the Rosemary oil for use in the present invention was sourced from Shiva Export Corporation, India.
  • the extract of Rosmarinus officinalis is preferably included in the composition on a dry weight basis at 0.01 to 2% preferably 0.05 to 1 % by weight of the composition.
  • the shampoo composition of the invention may additionally comprise 0.01 to 1 % on dry weight basis of Aloe vera (Aloe Barbadenisis) aqueous extract.
  • Aloe vera (Aloe Barbadenisis) is well known herb for its soothing and nourishing properties and is also an anti-microbial agent. It is useful in shampoo formulations for nourishing scalp and works along with the other ingredients for anti-dandruff benefit. It has been sourced as a powder for use in the present invention from Chemiloids, India.
  • the extract of Aloe vera (Aloe Barbadenisis) in the composition is preferably included on a dry weight basis at 0.01 to 2%, more preferably 0.05 to 2%, furthermore preferably 0.1 to 2% by weight of the composition.
  • the Aloe vera for use in the present invention is preferably prepared by a process where the leaves of Aloe barbadensisis are subjected to hot water extraction. The recovered water extract is then concentrated and then dried and crushed to a powder.
  • composition of the present invention may additionally comprise Natural Menthol (, Mentha arvensis) obtained from corn mint, peppermint, or other mint oils.
  • Natural Menthol (, Mentha arvensis) obtained from corn mint, peppermint, or other mint oils.
  • the present invention may additionally comprise an essential oil blend to impart pleasant odour to the shampoo composition.
  • These essential oil blends may additionally enhance the antidandruff efficacy.
  • These essential oil blends may comprise oils from plants like basil, patchouli, turmeric, citronella, cinnamon leaf, cedar wood, peppermint, orange, lemon, lime, petitgrain and lemon grass. Of these, essential oils like lemon oil, petit grain oil, basil and patchouli are more preferred for inclusion in the composition of the invention.
  • These additional essential oils are preferably included in 0.5 to 10% by weight of the composition.
  • the composition of the invention preferably additionally comprises a cosmetically acceptable carrier.
  • the carrier is preferably chosen such that the composition of the invention can be delivered for use as an antidandruff shampoo composition.
  • the cosmetically acceptable carrier is water or an aqueous solution.
  • the carrier additionally comprises a surfactant.
  • the cosmetically acceptable vehicle is such that the composition can be prepared as a shampoo, conditioner, body wash, hand wash or face wash product, cream, lotion, gel, powder, ointment, or a soap bar.
  • the composition is a shampoo.
  • the composition of the invention especially shampoos are formulated with an anionic surfactant e.g. an alkyl sulphate and/or ethoxylated alkyl sulfate surfactant.
  • anionic surfactants are preferably present at a level of from 1 to 20%, preferably 2 to 16%, further more preferably from 3 to 16% by weight of the composition.
  • Preferred alkyl sulfates are C8 to 18 alky sulfates, more preferably C12 to 18 alkyl sulfates, preferably in the form of a salt with a solubilising cation such as sodium, potassium, ammonium or substituted ammonium.
  • Preferred alkyl ether sulfates are those having the formula: R0(CH 2 CH 2 0) n SC> 3 M;
  • R is an alkyl or alkenyl group having from 8 to 18 (preferably 12 to 18) carbon atoms; n is a number having an average value of greater than at least 0.5, preferably between 1 and 3, more preferably between 2 and 3; and M is a solubilising cation such as sodium, potassium, ammonium or substituted ammonium.
  • An example is sodium lauryl ether sulfate (SLES). SLES having an average degree of ethoxylation of from 0.5 to 3, preferably 1 to 3 is especially preferred.
  • Shampoo compositions according to the invention may comprise one or more further anionic cleansing surfactants which are cosmetically acceptable and suitable for topical application to the hair.
  • a composition of the invention preferably additionally comprises an amphoteric surfactant preferably a betaine surfactant preferably an alkyl amidopropyl betaine surfactant for example cocamidopropyl betaine.
  • the composition comprises from 0.1 to 10 wt.%, preferably from 0.5 to 8 wt.%, more preferably from 1 to 5 wt.% of a betaine surfactant.
  • cationic polymers are generally included therein.
  • the composition additionally includes 0.01 to 2.0% of a cationic polymer.
  • the cationic polymer is preferably guar hydroxypropyl trimonium chloride.
  • Guar polymer predominantly contains galactomannan polymer chains. This polymer is available at various molecular weights and degree of cationic substitutions depending on how much the guar has been hydrolysed and cationised.
  • the cationic polymer is preferably present in 0.04 to 0.5%, more preferably 0.08 to 0.25% by weight of the composition.
  • the pH of the composition is preferably equal to or higher than 4.0, more preferably in the range of 5.0 to 10.0.
  • composition of the invention further comprises a suspending agent.
  • suspending agents are selected from polyacrylic acids, cross-linked polymers of acrylic acid, copolymers of acrylic acid with a hydrophobic monomer, copolymers of carboxylic acid-containing monomers and acrylic esters, cross-linked copolymers of acrylic acid and acrylate esters, heteropolysaccharide gums and crystalline long chain acyl derivatives.
  • Suspending agent if included, will generally be present in a shampoo composition of the invention at levels of from 0.1 to 10%, preferably from 0.5 to 6%, more preferably from 0.5 to 4% on the total weight of the composition.
  • composition of the invention may contain other ingredients for enhancing performance and/or consumer acceptability.
  • ingredients include fragrance, dyes and pigments, pH adjusting agents, pearlescers or opacifiers, viscosity modifiers, preservatives, and natural hair nutrients such as botanicals, fruit extracts, sugar derivatives and amino acids.
  • the composition of the invention is preferably aqueous based.
  • Water is a preferred carrier. When water is present, it is preferably present in at least 1 %, more preferably at least 2%, further more preferably at least 5% by weight of the composition.
  • water when water is the carrier, it is preferred that the composition of the invention comprises 10 to 90% by weight water.
  • the composition of the invention preferably comprises high amounts of water preferably from 70 to 95% by weight of the composition.
  • Conditioning benefits may also be delivered through the shampoo composition of the invention by including a conditioning agent therein.
  • the most popular conditioning agents used in hair care compositions are water-insoluble oily materials such as mineral oils, naturally occurring oils such as triglycerides and silicone polymers. Conditioning benefit is achieved by the oily material being deposited onto the hair resulting in the formation of a film, which makes the hair easier to comb when wet and more manageable when dry.
  • An especially useful conditioning agent is a silicone compound, preferably a non-volatile silicone compound.
  • Advantageously compositions herein may include one or more silicones.
  • the silicones are conditioning agents found in dispersed or suspended particulate form. They are intended to deposit onto hair remaining behind after rinsing of the hair with water.
  • Suitable silicone oils may include polyalkyl siloxanes, polyaryl siloxanes, polyalkylaryl siloxanes, polyether siloxane copolymers and mixtures thereof.
  • Amino silicones are often formulated with shampoo compositions. Amino silicones are silicones containing at least one primary amine, secondary amine, tertiary amine or a quaternary ammonium group. High molecular weight silicone gums can also be utilized.
  • Another useful type are the crosslinked silicone elastomers such as Dimethicone/Vinyl/Dimethicone Crosspolymers (e.g. Dow Corning 9040 and 9041 ).
  • Amounts of the silicone in compositions where present may range from about 0.1 to about 10 wt.%, preferably from about 0.1 to about 8wt.%, more preferably from about 0.3 to about 5wt.% by weight of the hair care compositions.
  • compositions may include other known ingredients such as perfumes, pigments, preservatives, emollients, sunscreens, emulsifiers, gelling agents and thickening agents. Choice of these ingredients will largely depend on the format of the composition.
  • the invention also relates to a method of providing anti dandruff benefit to scalp comprising applying a composition of the invention on to scalp and optionally followed by rinsing the surface with water.
  • the method is preferably for providing non-therapeutic benefits.
  • composition for delivering anti- dandruff benefits which is preferably non-therapeutic.
  • Anti dandruff actives was a mixture of 1 % palmarosa oil, 1 % extract of Azhadirachta indica and 0.5% of extract of Phyllanthus emblica (all on dry weight basis)
  • the shampoo samples were tested for antifungal efficacy using the following protocol: Microorganism Used: MJurfur ATCC 14521 and Concentration of the Sample: Neat
  • the working culture was prepared by streaking the test culture from glycerol stock on sterile Modified Dixon Agar (MD), the plates were incubated at 32°C for 72 hrs. Similarly, a second subculture was prepared from first subculture. From second subculture a loopful of culture was inoculated in 10ml sterile Pityrosporum Broth (PB), the tube was incubated at 32°C for 72 to 96 hours. For fourth subculture, 1 ml of broth culture from third subculture was inoculated into fresh 10 ml sterile Pityrosporum Broth (PB), the tube was incubated at 32°C for 48 hours.
  • PB sterile Modified Dixon Agar
  • the Vitro-Skin was cut into 5.2 x 5.2 cm 2 squares using a pair of scissors and ruler which have been pre-sterilized by swabbing with 70% isopropyl alcohol.
  • the dried XRF cells were inoculated with 0.2 ml of agar slurry.
  • the agar slurry was spread on to the surface of the artificial skin using sterile glass rods.
  • the bottle containing the skin and neutralizer was sonicated for 2 min in an ultrasonic water bath.
  • the data on the antifungal activity in terms of log reduction is summarized in Table - 2 below:
  • Table - 2 indicates that a composition as per the invention (Example 1 ) comprising purely natural actives provide provides for anti malassezia efficacy comparable to the best synthetic active (Example - A) presently available.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition antipelliculaire comprenant de 0,1 à 5 % d'huile de Palmarosa (Cymbopogon martyinii) et de 0,1 à 5 % sur une base en poids sec d'extrait aqueux d'un ou de plusieurs éléments choisis parmi Azadirachta indica ou Phyllanthus emblica, la composition comprenant des extraits aqueux d'Azadirachta indica et de Phyllanthus emblica.
PCT/EP2019/066070 2018-07-26 2019-06-18 Composition antipelliculaire WO2020020539A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18185684.0 2018-07-26
EP18185684 2018-07-26

Publications (1)

Publication Number Publication Date
WO2020020539A1 true WO2020020539A1 (fr) 2020-01-30

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Application Number Title Priority Date Filing Date
PCT/EP2019/066070 WO2020020539A1 (fr) 2018-07-26 2019-06-18 Composition antipelliculaire

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AR (1) AR117625A1 (fr)
WO (1) WO2020020539A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050191267A1 (en) 2004-02-04 2005-09-01 Omboon Luanratana Anti-photoaging cosmeceutical composition
WO2010086717A2 (fr) 2009-01-30 2010-08-05 Himalaya Global Holdings Limited Compositions nettoyantes à base de plantes et leur procédés de préparation
WO2014195872A1 (fr) * 2013-06-04 2014-12-11 Vyome Biosciences Pvt. Ltd. Particules enrobées et compositions les comprenant

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050191267A1 (en) 2004-02-04 2005-09-01 Omboon Luanratana Anti-photoaging cosmeceutical composition
WO2010086717A2 (fr) 2009-01-30 2010-08-05 Himalaya Global Holdings Limited Compositions nettoyantes à base de plantes et leur procédés de préparation
WO2014195872A1 (fr) * 2013-06-04 2014-12-11 Vyome Biosciences Pvt. Ltd. Particules enrobées et compositions les comprenant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE GNPD [online] MINTEL; 24 May 2018 (2018-05-24), ANONYMOUS: "Voluminising Jatamansi Hair Cleanser", XP055539489, retrieved from www.gnpd.com Database accession no. 5699875 *

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