WO2020020205A1

WO2020020205A1 - Endoscopic ultrasonography flexible microwave ablation needle

Info

Publication number: WO2020020205A1
Application number: PCT/CN2019/097425
Authority: WO
Inventors: 于春生; 江荣华; 杨小唤; 隆龙
Original assignee: 南京康友医疗科技有限公司
Priority date: 2018-07-26
Filing date: 2019-07-24
Publication date: 2020-01-30
Also published as: CN108938080B; CN108938080A

Abstract

An endoscopic ultrasonography flexible microwave ablation needle, comprising a handle (01), a radio frequency coaxial connector (7) and a microwave radiation antenna (9), the radio frequency coaxial connector (7) being arranged on the handle (01), the radio frequency coaxial connector (7) being connected to the microwave radiation antenna (9) via a radio frequency coaxial cable (8), a capillary tube (10) and an inner tube (11) being sequentially arranged around the radio frequency coaxial cable (8), the radio frequency coaxial cable (8) being arranged within the capillary tube (10), the capillary tube (10) being arranged within the inner tube (11), the inner tube (11) comprising a first end portion (110) and a second end portion (111), the first end portion (110) extending to the microwave radiation antenna (9), the second end portion (111) being away from the microwave radiation antenna (9), the inner tube (11) gradually thinning from the second end portion (111) to the first end portion (110). The ablation needle is capable of reaching more lesions, and has strong penetrability.

Description

Flexible microwave ablation needle under ultrasound endoscope

Cross-reference to related applications

This disclosure claims the priority of a Chinese patent application filed on July 26, 2018 with the application number of 201810833418.9 and the name "A Flexible Microwave Ablation Needle Under Ultrasound Endoscope" filed with the China Patent Office.

Technical field

The present disclosure relates to the field of microwave therapeutic medical devices, and in particular, to a flexible microwave ablation needle under ultrasound endoscope configured to perform microwave ablation treatment of tumors and diseased tissues inside the abdominal cavity.

Background technique

At present, China's medical industry is developing by leaps and bounds, and at the same time, the demand for products is becoming more and more fine. Microwave ablation, as a minimally invasive surgery, is becoming more and more widely used. Microwave ablation is using the thermal effect of microwave biological tissues to treat lesions. Tissues perform hemostasis, coagulation, burning, anti-inflammatory, swelling, analgesia, or improve local tissue blood circulation to achieve the effect of treating diseases. It has the advantages of less trauma, quick effect and strong penetrating ability, and is accepted by more and more patients.

Most of the existing microwave ablation minimally invasive surgery use ultrasound or X-ray imaging equipment to locate the lesion, and then use an external ablation needle to percutaneously puncture the microwave ablation after reaching the lesion. This minimally invasive microwave ablation is limited by external conditions such as the patient's physical conditions, the location of the lesion, and the length of the ablation antenna. At the same time, the puncture needle path cannot completely ensure that the lesion can be safely and accurately reached. With the increasing maturity of microwave ablation technology, the demand for microwave ablation needles is becoming more and more refined. The emergence of an endoscopic microwave needle has improved the microwave ablation technology to a new level, and the new technology is more intuitive with the help of endoscopes. Direct the microwave radiation antenna to the tumor and diseased tissue. This requires a flexible ablation needle that can pass freely through the endoscope, and also requires that the ablation needle has a certain puncture force. It is also imperative to choose different ablation needles for different parts. Because some organs in the thoracic cavity and abdominal cavity can reach the lesion directly with the help of ultrasound endoscopy, and short hard needles on the market appear to be helpless, flexible endoscopic ablation needles have emerged, providing an additional preferred treatment plan for doctors and patients. It has been clinically recognized by the market. As people pay more and more attention to health, lung cancer, liver cancer and pancreatic cancer increase in society, and flexible endoscopic ablation needles have broad market prospects.

Summary of the Invention

The purpose of the present disclosure includes, for example, providing an ablation needle with good flexibility, which can effectively solve the problems of difficult puncture and positioning of the ablation needle, and can reach more lesions, and has strong penetrability.

The embodiments of the present disclosure are implemented as follows:

An embodiment of the present disclosure provides a flexible microwave ablation needle under ultrasound endoscope, including a handle, a radio frequency coaxial connector, and a microwave radiation antenna. The radio frequency coaxial connector is disposed on the handle, and the radio frequency coaxial The connector is connected to the microwave radiation antenna through a radio frequency coaxial cable, and a capillary tube and an inner tube are sequentially arranged on the periphery of the radio frequency coaxial cable. The radio frequency coaxial cable is placed in the capillary tube, and the capillary tube is disposed. In the inner pipe, the capillary tube communicates with a water inlet pipe as a cooling water passage, the capillary outer wall and the inner pipe inner wall form a drainage pipe, and the drainage pipe communicates with a water outlet pipe, and water entering the cooling water passage passes through the water pipe. The drainage pipe is discharged, the inner pipe includes a first end portion and a second end portion, the first end portion extends to the microwave radiation antenna, the second end portion is far from the microwave radiation antenna, and the inner tube It tapers from the second end to the first end.

Optionally, the inner tube is made of a material that can withstand high temperatures and can be bent, such as poly (phenylene ether ether ketone), polyimide, nickel-titanium alloy tube, PTFE tube, or medical composite material composite braided tube.

Optionally, the capillary is made of a material that can withstand high temperatures and can be bent, such as a nickel-titanium alloy tube, a 304 stainless steel tube, a PTFE tube, a medical composite multilayer braided tube, poly (phenylene ether ether ketone), or polyimide, The capillary is covered outside the microwave radiation antenna.

Optionally, it further includes a first temperature sensor connected to the capillary tube and configured to detect a temperature of the microwave radiation antenna.

Optionally, it further comprises an outer tube connected to the handle, and the outer tube is sleeved outside the inner tube.

Optionally, the outer tube is tapered from an end far from the microwave radiation antenna to an end closer to the microwave radiation antenna.

Optionally, the outer tube is made of a material that can withstand high temperatures and can be bent, such as poly (phenylene ether ether ketone), a nickel-titanium alloy tube, a PTFE tube, a medical composite multilayer braided tube, or a polyimide.

Optionally, it further includes a sliding member, a connecting member, and a plurality of second temperature sensors. The connecting member includes a sliding portion and a plurality of deformed portions connected to the sliding portion. The plurality of deformed portions are along the sliding portion. The sliding members are arranged at intervals in the circumferential direction, and the slider is connected to the sliding portion, and the sliding portion is located between the inner tube and the outer tube, and slides with the inner tube in the axial direction of the inner tube. Fit; the sliding member slides with the handle, and when the connecting member slides relative to the inner tube, the deformed portion can extend out of the inner tube and the outer tube and along the inner tube. Open radially outward, or the deformed portion can be retracted between the inner tube and the outer tube; the plurality of the second temperature sensors correspond to the plurality of the deformed portions one by one and are configured to detect The temperature around the ablation tissue to determine the size of the ablation area.

Optionally, the sliding portion is sleeved outside the inner tube.

Optionally, the sliding portion is provided with a braided tube, and a plurality of the deformed portions are integrally knitted with the braided tube.

Optionally, the handle includes a first handle, a telescopic handle, and a second handle connected in sequence, and the telescopic handle and the first handle or / and the second handle are along the axis of the radio frequency coaxial cable. Sliding cooperation; the RF coaxial connector is disposed on the first handle, a first through hole penetrating through both ends of the length direction of the telescopic handle is provided in the telescopic handle, and the second handle is provided with A second through hole penetrating through both ends in the length direction of the second handle, one end of the radio frequency coaxial cable, the capillary tube, and the inner tube is connected to the first handle, and the radio frequency coaxial cable The other ends of the capillary tube and the inner tube pass through the first through hole and the second through hole in sequence and protrude from the end of the second through hole away from the first through hole.

Optionally, the telescopic handle is slidably connected to the first handle.

Optionally, a locking device is provided between the telescopic handle and the first handle to prevent the two from sliding relative to each other.

Optionally, the locking device includes a snap ring connected to the first handle, the snap ring is provided with a protrusion, the outer peripheral surface of the telescopic handle is provided with a snap groove, and the snap ring can be along a diameter To deform to engage the protrusion in the slot, thereby restricting the first handle from sliding relative to the telescopic handle; or to separate the protrusion from the slot, thereby causing the The first handle and the telescopic handle can slide relative to each other.

Optionally, the first handle is provided with a hollow area, and the telescopic handle is inserted in the hollow area and can slide relative to the first handle.

Optionally, the handle is provided with an isolation cavity, the isolation cavity includes a water inlet cavity and a water outlet cavity separated from each other, the capillary tube communicates with the water inlet pipe through the water inlet cavity, and the drainage channel passes through the water inlet The water outlet cavity communicates with the water outlet pipe.

Optionally, the microwave radiation antenna is a triangular pyramid antenna, a bevel antenna, or a cone antenna.

The beneficial effects of this disclosure include, for example:

1. The inner tube in the present disclosure adopts a tapered diameter to make the front end thin and thick. Under the condition of ensuring the required strength of the inner tube, the front end can be bent to reach more lesions, and the design increases the inner tube. 2. The present disclosure makes full use of the pipe between the inner tube and the capillary tube as a cooling water drainage channel, so that the cooling water in the capillary tube flows to the microwave radiation antenna and is discharged by the drainage channel, so that the cooling water channel and drainage The channels are separated from each other to ensure the cooling efficiency; 3. The inlet and outlet pipes in the present disclosure are arranged on the same side, which facilitates the management of the inlet and outlet cooling water; 4. The outer tube in the present disclosure is arranged outside the inner tube, and The thickness of the inner tube changes in the same direction. On the one hand, it not only protects the microwave radiation antenna and the reduced diameter inner tube from external force damage, but also acts as a freely retractable passage for the reduced diameter inner tube. On the other hand, it can isolate the microwave radiation antenna and prevent damage to the inner wall of the ultrasonic endoscope; The design of the present disclosure using a telescopic handle can change the length of the microwave radiation antenna deep into the body by changing the relative position of the first handle and the telescopic handle to achieve extensibility. Function; 6, the present disclosure isolation chamber such that the inlet chamber and the outlet chamber separated rod designs can effectively reduce the temperature, thus reducing energy consumption during microwave ablation of normal tissue damage, and endoscopy.

BRIEF DESCRIPTION OF THE DRAWINGS

In order to more clearly illustrate the technical solutions of the embodiments of the present disclosure, the drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present disclosure, and therefore are not It should be regarded as a limitation on the scope. For those of ordinary skill in the art, other related drawings can be obtained based on these drawings without paying creative work.

1 is a schematic structural diagram of a flexible microwave ablation needle in an embodiment of the present disclosure;

2 is a schematic cross-sectional view taken along the A-A direction in FIG. 1;

FIG. 3 is a partially enlarged schematic diagram at C in FIG. 1; FIG.

FIG. 4 is a partially enlarged schematic diagram at B in FIG. 1; FIG.

5 is a schematic cross-sectional structure diagram of a flexible microwave ablation needle in an embodiment of the present disclosure.

In the picture:

01-handle; 1-first handle; 2-telescopic rod, 3-second handle; 4-water inlet pipe; 5-water outlet pipe; 6-isolation cavity; 60-partition; 601- water inlet cavity; 602- water outlet Cavity; 7-RF coaxial connector; 8-RF coaxial cable; 9-microwave radiation antenna; 10- capillary; 11- inner tube; 110- first end; 111- second end; 12- outer 13-first temperature sensor; 14-ring; 15-cooling water channel; 16-drain channel; 17-first through hole; 18-second through hole; 19-slider; 20-connecting member; 201 -Sliding part; 202-deformation part; 21-second temperature sensor; 22-controller.

detailed description

In order to make the objectives, technical solutions, and advantages of the embodiments of the present disclosure more clear, the technical solutions in the embodiments of the present disclosure will be described clearly and completely in combination with the drawings in the embodiments of the present disclosure. Obviously, the described embodiments These embodiments are part of, but not all of, the embodiments of the present disclosure. The components of embodiments of the present disclosure, which are generally described and illustrated in the drawings herein, may be arranged and designed in a variety of different configurations.

Accordingly, the following detailed description of embodiments of the present disclosure provided in the accompanying drawings is not intended to limit the scope of the claimed disclosure, but merely to indicate selected embodiments of the present disclosure. Based on the embodiments in the present disclosure, all other embodiments obtained by a person of ordinary skill in the art without making creative efforts fall within the protection scope of the present disclosure.

It should be noted that similar reference numerals and letters indicate similar items in the following drawings, so once an item is defined in one drawing, it need not be further defined and explained in subsequent drawings.

In the description of this disclosure, it should be noted that if the terms "center", "up", "down", "left", "right", "vertical", "horizontal", "inside", "outside" appear The azimuth or positional relationship indicated by "" is based on the azimuth or positional relationship shown in the drawings, or the azimuth or positional relationship commonly used when the invention product is used, and is only for the convenience of describing the present disclosure and simplifying the description, rather than indicating Or it implies that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as a limitation on the present disclosure.

In addition, if the terms "first", "second", "third", etc. appear only to distinguish descriptions, they cannot be understood as indicating or implying relative importance.

In addition, the appearance of the terms "horizontal", "vertical", "overhang", etc. does not mean that the component is absolutely horizontal or overhanging, but may be slightly inclined. For example, “horizontal” simply means that its direction is more horizontal than “vertical”, which does not mean that the structure must be completely horizontal, but it can be tilted slightly.

In the description of the present disclosure, it should also be noted that, unless otherwise specified and limited, the terms "setup", "installation", "connected", "connected", etc. should be understood in a broad sense, for example, it may be A fixed connection can also be a detachable connection or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, or it can be the internal connection of two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present disclosure may be understood on a case-by-case basis.

It should be noted that, in the case of no conflict, the features in the embodiments of the present disclosure may be combined with each other.

As shown in FIG. 1, the flexible microwave ablation needle under ultrasound endoscope in the present disclosure includes a handle 01, a radio-frequency coaxial connector 7, a radio-frequency coaxial cable 8, a microwave radiation antenna 9, a capillary 10, an inner tube 11, and an outer tube. 12. The RF coaxial connector 7 is disposed on the handle 01. One end of the RF coaxial cable 8 is connected to the RF coaxial connector 7. The other end of the RF coaxial cable 8 is connected to a microwave radiation antenna 9. The microwave radiation antenna 9 includes energy transmission. The device is configured to emit the ablated microwaves, and its structure can be designed according to different requirements. For example, the microwave radiation antenna 9 can use a triangular pyramid antenna, a bevel antenna, or a conical antenna, and has excellent puncture function. A radio-frequency coaxial cable 8 passes through the lumen of the capillary tube 10 and protrudes from the capillary 10 at one end. The radio-frequency coaxial cable 8 has a microwave radiation channel. The radio-frequency coaxial cable 8 is configured to connect the microwave radiation antenna 9 and the radio-frequency coaxial cable. The connector 7 and the radio frequency coaxial cable 8 have a high dielectric constant and prevent microwave leakage. The RF coaxial cable 8 includes an outer layer, an intermediate layer, and an inner core which are arranged in order from the outside to the inside. The outer layer is provided as a copper shielding sheath, the middle layer is provided as a PTFE dielectric layer, and the inner core is provided. It is silver-clad steel, and the RF coaxial cable 8 adopts double-layer protection, and the protection effect is good. The capillary tube 10 is arranged in the inner tube 11 and extends from one end of the handle 01 to the microwave radiation antenna 9. The capillary tube 10 is covered by the RF coaxial cable 8. The lumen of the capillary tube 10 is used as the cooling water channel 15, and the cooling water channel 15 is connected. In the water inlet pipe 4, cooling water can enter the capillary tube 10 from the end of the capillary tube 10 far from the microwave radiation antenna 9 to reduce the temperature of the radio frequency coaxial cable 8 and ensure that the temperature of the radio frequency coaxial cable 8 is not excessively high. The inner tube 11 is covered by the capillary tube 10, and a drainage channel 16 is formed between the inner peripheral wall of the inner tube 11 and the outer peripheral wall of the capillary tube 10. The end of the capillary tube 10 that is far from the microwave radiation antenna 9 projects the drain channel 16, and the drain channel 16 and the outlet The water pipe 5 communicates, and the cooling water enters from the end of the capillary tube 10 away from the microwave radiation antenna 9, flows out from the other end of the capillary tube 10 near the microwave radiation antenna 9, enters the drainage channel 16, and is then discharged from the water outlet pipe 5. The outer tube 12 covers the outside of the inner tube 11.

In the present disclosure, optionally, the inner tube 11 is provided in a reduced diameter form. Both ends of the inner tube 11 along the length direction thereof extend to the handle 01 and the microwave radiation antenna 9, respectively. One end of the inner tube 11 connected to the microwave radiation antenna 9 is provided. It is designated as the first end portion 110, and the end of the inner tube 11 connected to the handle 01 is set as the second end portion 111. The pipe diameter (including the inner diameter and the outer diameter) of the inner tube 11 is directed from the second end portion 111 along its length direction. The first end portion 110 gradually becomes smaller, and the minimum diameter of the inner tube 11 is 1 mm. This design enables the thin end of the inner tube 11 to be bent, can reach more lesions, and improves the flexibility and success rate of the operation. In order to ensure the flexibility of the inner tube 11, the inner tube 11 is made of a material that is resistant to high temperatures and can be bent freely, such as PEEK (Polyetheretherketone polyphenylene ether ketone), PI (Polyimide polyimide), nickel-titanium alloy tube, PTFE Polytetrafluoroethylene) tube or medical composite material combined braided tube, these materials have good flexibility, and the bending of the inner tube 11 is more flexible. The inner tube 11 not only protects the capillary tube 10 and the radio-frequency coaxial cable 8, but also the drainage channel 16 formed between the inner peripheral wall of the inner tube 11 and the outer peripheral wall of the capillary tube 10 and the cooling channel 15 formed by the lumen of the capillary tube 10 itself. They are independent from each other, that is, the cooling water channel 15 and the drainage channel 16 are separated from each other, and the cooling water channel 15 is closer to the RF coaxial cable 8 than the drainage channel 16, which improves the cooling efficiency.

Optional in this disclosure, in order to ensure the flexibility of the capillary 10, the capillary 10 is made of a material that is resistant to high temperatures and can be bent freely, such as a nickel-titanium alloy tube, a 304 stainless steel tube, a PTFE (Polytetrafluoroethylene) tube, The medical composite material multi-layer braided tube, PEEK (Poly Ether Ketone Polyphenylene Ether Ketone) or PI (Polyimide Polyimide) makes the capillary 10 have the function of free bending and recoverable deformation, preventing the needle rod from being deformed.

As shown in FIG. 2, FIG. 2 shows a schematic cross-sectional view in the direction A-A in FIG. 1. The needle bar in the present disclosure includes an outer tube 12, an inner tube 11 covered with the outer tube 12, a capillary tube 10 covered with the inner tube 11, and a radio frequency coaxial cable 8 covered with the capillary tube 10. The lumen of the capillary tube 10 serves as the cooling water channel 15. A drainage channel 16 is formed between the outer peripheral wall of the capillary tube 10 and the inner peripheral wall of the inner tube 11. The diameter of the outer tube 12 is the same, and the diameter of the outer tube 12 is gradually tapered from one end to the other along its length. The outer tube 12 is made of materials that can withstand high temperatures and can be bent freely, such as PEEK (Polyetheretherketone), PI (Polyimide), nickel-titanium alloy tubes, PTFE (Polytetrafluoroethylene) Tube or medical composite material multi-layer braided tube. The outer diameter of the outer tube 12 is a maximum of 3.7mm. The outer tube 12 has a good bendability and double protection. On the one hand, it protects the microwave radiation antenna 9 and the inner tube 11 from being damaged. Damaged by external force also serves as a freely retractable channel for the inner tube 11; on the other hand, it can isolate the microwave radiation antenna 9 to prevent damage to the inner wall of the ultrasonic endoscope. Both ends of the outer tube 12 along the length direction thereof extend to the handle 01 and the microwave radiation antenna 9, respectively, and the length of the outer tube 12 is more than 1.5 m.

As shown in FIG. 3, a partially enlarged schematic diagram at C in FIG. 1 is shown in FIG. 3. The microwave radiation antenna 9 adopts a triangular pyramid antenna, a bevel antenna, or a cone antenna, and has excellent puncture function. A first temperature sensor 13 is installed on the needle bar, and the first temperature sensor 13 extends to the front end of the microwave radiation antenna 9 to accurately monitor the temperature of the needle bar in real time to prevent the temperature of the needle bar from being too high and causing damage to normal tissue and internal damage. Mirror, when the temperature detected by the first temperature sensor 13 exceeds a set value, the first temperature sensor 13 can feedback the detected temperature to the control system, and then cut off the microwave output. Optionally, the first temperature sensor 13 is connected to the capillary tube 10 and is disposed near the microwave radiation antenna 9.

As shown in FIG. 4, FIG. 4 shows a partially enlarged schematic diagram at B in FIG. 1. An isolation cavity 6 is provided in the handle 01. The isolation cavity 6 includes a water inlet cavity 601 and a water outlet cavity 602 that are separated from each other. The water inlet cavity 601 and the water outlet cavity 602 are sequentially arranged along the length direction of the needle rod. Optionally, the isolation cavity 6 A partition 60 is provided in the partition, and the partition 60 separates the isolation chamber 6 into an independent water inlet chamber 601 and a water outlet chamber 602. The end of the capillary tube 10 far from the microwave radiation antenna 9 protrudes from the port corresponding to the drainage channel 16. The capillary tube 10 passes through the partition plate 60 and communicates with the water inlet cavity 601. The corresponding end of the drainage channel 16 extends into the water outlet cavity 602 and communicates with the water outlet cavity 602. After the circuit is formed, the cooling water after the cold and heat exchange is led out, thereby reducing the temperature of the needle bar. The water inlet chamber 601 is connected to the water inlet pipe 4 and the water outlet chamber 602 is connected to the water outlet pipe 5. The structural design of the isolation chamber 6 makes the water inlet and the water phase isolated, which can effectively reduce the temperature of the needle bar. The capillary tube 10 and the inner tube 11 are independently connected to the isolation cavity 6 as circulating cooling paths, which can save space. The endoscopic ablation needle can be designed thinner, ensure good cornering performance, and can freely switch directions in the endoscope.

As shown in FIG. 5, a schematic cross-sectional view of an ablation needle is shown. The handle 01 in the present disclosure includes a first handle 1, a telescopic handle 2, and a second handle 3. The telescopic handle 2 is connected to the first handle 1 and the second handle 3. The first handle 1 is provided with a radio-frequency coaxial connector 7 and an isolation cavity 6. The telescopic handle 2 is provided with a first through-hole 17, and the first through-hole 17 extends along the telescope. The length direction of the handle 2 runs through both ends of the telescopic handle 2. A second through hole 18 is provided in the second handle 3, and the second through hole 18 penetrates both ends of the second handle 3 along the length direction of the second handle 3. The RF coaxial cable 8 passes through the first through hole 17 and the second through hole 18 in sequence from the first handle 1 and extends out of the second handle 3. The length extension direction of the capillary tube 10 is consistent with the length extension direction of the inner tube 11. The length of the capillary tube 10 extends from the water inlet cavity 601 of the isolation cavity 6 to the microwave radiation antenna 9, and the length of the inner tube 11 extends from the water outlet cavity 602 of the isolation cavity 6 to the microwave radiation antenna 9. The outer tube 12 is fixed at an end of the second handle 3 away from the telescopic handle 2. The outer tube 12 communicates with the second through hole 18, and the outer tube 12 may be integrated with the second handle 3. The diameter of the outer tube 12 is connected along its length. One end of the second handle 3 is gradually tapered toward the other end, and the length of the outer tube 12 may be set to be more than 1.5m.

In the present disclosure, in order to ensure that the microwave radiation antenna 9 is retractable in the human body, the telescopic handle 2 is slidably connected to the first handle 1. Optionally, one end of the first handle 1 connected to the telescopic handle 2 is hollow, one end of the telescopic handle 2 extends into the hollow area of the first handle 1, and the length of the telescopic handle 2 extending into the first handle 1 is changed by sliding the telescopic handle 2 That is, the distance between the first handle 1 and the second handle 3 is changed, and finally the depth of the microwave radiation antenna 9 protruding into the human body is adjusted.

In order to facilitate fixing the relative positions of the telescopic handle 2 after adjusting the length that the telescopic handle 2 extends into the first handle 1, the first handle 1 and the telescopic handle 2 are connected by a locking device. Optionally, the telescopic handle 2 and the first handle 1 are fixed by using a structure in which the guide rail and the guide groove are engaged with each other to prevent the telescopic handle 2 and the first handle 1 from rotating relatively. Optionally, the locking device includes a snap ring 14 connected to the first handle 1 and located at an end of the first handle 1 connected to the telescopic handle 2. The telescopic handle 2 passes through the snap ring 14 and extends into the first handle 1 Hollow area. A slot is provided on the outer peripheral wall of the telescopic handle 2, and a protrusion corresponding to the slot is provided on the inner peripheral wall of the snap ring 14. After the protrusion is snapped into the slot, the position between the telescopic handle 2 and the first handle 1 is provided. Relatively fixed, the telescopic handle 2 and the first handle 1 cannot slide relative to each other. In order to clearly understand the depth of the needle shaft, a scale is provided on the telescopic handle 2, and the scale can clearly indicate the depth of the ablation needle.

The specific operation of the length adjustment of the handle 01 is: pressing the snap ring 14, the first handle 1 can slide together with the isolation cavity 6, the reducing inner tube 11 and the microwave radiation antenna 9; loosening the snap ring 14, the telescopic handle 2 has The zigzag-shaped clamping grooves and the elastic buckles are embedded in the clamping grooves of the telescopic handle 2 so as to fix the telescopic handle 2 to prevent it from moving back and forth relative to the first handle 1. The snap ring 14 has a built-in elastic buckle. Press the snap ring 14 to release the snap slot to release the snap ring. The snap ring 14 is loosened. The elastic snap catches the snap slot of the telescopic handle 2 by itself. The structure is similar to a lock. End quick plug connector structure.

In the present disclosure, optionally, the microwave ablation needle further includes a slider 19, a connecting member 20, a plurality of second temperature sensors 21, and a controller 22. The slider 19 is slidably connected to the first handle 1, and the sliding of the slider 19 The direction is parallel to the axis direction of the first handle 1, and the slider 19 and the first handle 1 are relatively fixed in the radial direction of the first handle 1, that is, the slider 19 does not fall off from the first handle 1, and the use is safe and reliable. Optionally, the sliding member 19 may be a slider, and the surface of the sliding member 19 may be provided with a non-slip pattern, which increases the friction between the operator's hand and the sliding member 19, facilitates the sliding of the sliding member 19, and is not easy to slip. The connecting member 20 includes a tubular sliding portion 201 and a plurality of deforming portions 202 connected to the sliding portion 201. The plurality of deforming portions 202 are evenly spaced along the circumferential direction of the sliding portion 201. Each deforming portion 202 may be provided as an elastic piece. The sliding portion 201 is sleeved outside the inner tube 11 and is located inside the outer tube 12. In other words, the sliding portion 201 is located between the inner tube 11 and the outer tube 12. The sliding portion 201 can slide back and forth along the axial direction of the inner tube 11 relative to the inner tube 11 or the outer tube 12. During the sliding process of the connecting member 20, the multiple deformed portions 202 may be retracted between the outer tube 12 and the inner tube 11, or the multiple deformed portions 202 may also extend from between the outer tube 12 and the inner tube 11. The deformed portions 202 are deformed outward in the radial direction of the inner tube 11 after being extended, so that the deformed portions 202 are opened. The plurality of second temperature sensors 21 are in one-to-one correspondence with the plurality of deformation portions 202, or, in other embodiments, a plurality of second temperature sensors 21 are provided on each deformation portion 202. A second temperature sensor 21 is installed on each deformed portion 202, and each second temperature sensor 21 opens or retracts following the corresponding deformed portion 202. During the ablation process, the sliding member 19 is pushed so that the deformed portion 202 protrudes from the inner tube 11 and is opened by a certain angle α, for example, 0 ° <α≤150 °. The plurality of second temperature sensors 21 are uniformly arranged around the sliding portion 201 in a dispersed manner, and the plurality of second temperature sensors 21 are distributed around the microwave radiation antenna 9. Each of the second temperature sensors 21 is configured to detect a tissue temperature. In addition, the open range of the second temperature sensor 21 is proportional to the distance pushed by the slider 19, so that the size of the ablation area can be accurately confirmed. The plurality of second temperature sensors 21 are all communicatively connected to the controller 22, for example, the plurality of second temperature sensors 21 and the controller 22 may be connected by a conductor in a braided layer. The controller 22 is connected to the handle 01 and is located inside the handle 01. The controller 22 is configured to obtain the temperature detected by the second temperature sensor 21 and can display the temperature to the terminal, so that the operator can perform corresponding operations according to the obtained temperature value.

In the present disclosure, optionally, the sliding portion 201 is an annular braided tube, the deformed portion 202 is an elastic strip, and the deformed portion 202 is integrally knitted with the annular braided tube.

The present disclosure adopts a combined structure of a reduced inner tube and a reduced outer tube. The outer tube 12 is sleeved outside the inner tube 11, and a channel is formed between the outer tube 12 and the inner tube 11 to isolate the outside. On the one hand, heat is isolated during ablation. The inner tube 11 is in contact with the endoscope clamp channel, which effectively protects the endoscope. On the other hand, the triangular pyramid structure of the microwave radiation antenna 9 and the thicker and thinner inner tube 11 at the front end effectively reduce puncture resistance and are more conducive to puncture. Lesion tissue, internal ablation. At the same time, the outer tube 12 and the inner tube 11 are both provided with a reducing structure made of the materials listed above, which can restore the curved flexible ablation needle to its original state without affecting the cooling ablation effect.

Compared with the existing microwave ablation needles, the present disclosure can effectively solve the problems of difficult puncture and positioning of the needles. It can be positioned endoscopically, can reach the location of the lesion intuitively and clearly, and then use ultrasonic endoscopic clamping to make the flexible The microwave ablation needle is delivered to the location of the lesion. At the same time, the unique isolated multi-cavity structure of the invention can effectively reduce the temperature of the needle rod and reduce the damage to the endoscope and normal tissue by the energy consumption during the microwave ablation process. At the same time, by arranging a plurality of second temperature sensors 21 around the microwave radiation antenna 9, the present disclosure can more accurately estimate the size of the ablation area and achieve more accurate ablation treatment.

The working principle of the present disclosure is: power signal: microwave output device → via RF coaxial connector 7 → RF coaxial cable 8 → through handle 01 → into isolation cavity 6 → inner tube 11 → microwave radiation antenna 9 to radiate energy;

Protection circuit: return water temperature in the drainage pipe 16 → temperature measurement by the first temperature sensor 13 → the temperature of the needle rod exceeds the set value → feedback microwave output device → cut off the microwave output.

Cooling loop: water inlet pipe 4 → water inlet chamber 601 in isolation chamber 6 → capillary 10 → inner tube 11 → first temperature sensor 13 detects the temperature of the needle rod → water outlet chamber 602 in isolation chamber 6 → return water after heat exchange →出水管 5。 Water pipe 5.

Principle of pre-determining the size of the ablation area: Slide 19 forwards → Slide 201 advances → Deformation section 202 opens → Temperature measurement of the second temperature sensor 21 → Transmission of the inner conductor of the braided tube of Slide 201 → Controller 22 at the handle → Feedback to Device display → judge ablation size based on feedback temperature.

The above are only preferred embodiments of the disclosure, and the disclosure is not limited to the content of the embodiments. For those skilled in the art, there can be various changes and modifications within the scope of the technical solution of the present disclosure, and any modification, equivalent replacement, or improvement made is within the protection scope of the present disclosure.

Industrial applicability:

In summary, the present disclosure provides a flexible microwave ablation needle under ultrasound endoscope, which has strong penetrability and good treatment effect.

Claims

A flexible microwave ablation needle under an ultrasound endoscope, comprising a handle, a radio-frequency coaxial connector and a microwave radiation antenna. The radio-frequency coaxial connector is disposed on the handle, and the radio-frequency coaxial connector is connected with the radio-frequency coaxial connector. The microwave radiation antenna is connected by a radio frequency coaxial cable, and a capillary tube and an inner tube are sequentially arranged at the periphery of the radio frequency coaxial cable. The radio frequency coaxial cable is placed in the capillary tube, and the capillary tube is placed in the capillary tube. In the inner pipe, the capillary tube communicates with a water inlet pipe as a cooling water passage, and an outer wall of the capillary tube and an inner wall of the inner pipe form a drainage pipe, and the drainage pipe communicates with a water outlet pipe, and water entering the cooling water passage passes through The drainage pipe is discharged, the inner pipe includes a first end portion and a second end portion, the first end portion extends to the microwave radiation antenna, the second end portion is far from the microwave radiation antenna, and the inner portion The tube tapers from the second end to the first end.
The flexible microwave ablation needle under ultrasound endoscope according to claim 1, wherein the inner tube is made of a material that is resistant to high temperatures and can be bent.
The flexible microwave ablation needle under ultrasound endoscope according to claim 1 or 2, characterized in that: the inner tube is made of poly (phenylene ether ether ketone), polyimide, nickel-titanium alloy tube, PTFE tube or medical composite material combination Made of braided tube.
The flexible microwave ablation needle under ultrasound endoscope according to any one of claims 1-3, characterized in that the capillary is made of a material that is resistant to high temperatures and can be bent.
The flexible microwave ablation needle under ultrasound endoscope according to any one of claims 1-4, wherein the capillary tube is a nickel-titanium wire tube, poly (phenylene ether ether ketone), polyimide, or 304 stainless steel tube. , Nickel-titanium alloy tube, PTFE tube or medical composite multilayer braided tube.
The ultrasonic endoscopic flexible microwave ablation needle according to any one of claims 1-5, further comprising a first temperature sensor, the first temperature sensor being connected to the capillary tube and configured to detect the capillary tube. Microwave radiation antenna temperature.
The flexible microwave ablation needle under ultrasound endoscope according to any one of claims 1-6, further comprising an outer tube, the outer tube is connected to the handle, and the outer tube is sleeved on the Outer tube.
The flexible microwave ablation needle under ultrasound endoscope according to claim 7, wherein the outer tube is tapered from an end far from the microwave radiation antenna to an end closer to the microwave radiation antenna.
The flexible microwave ablation needle under ultrasound endoscope according to claim 7 or 8, wherein the outer tube is made of a material that is resistant to high temperatures and can be bent.
The flexible microwave ablation needle under ultrasound endoscope according to any one of claims 7-9, wherein the outer tube is made of poly (phenylene ether ether ketone), polyimide, nickel-titanium alloy tube, PTFE tube or Made of medical composite multilayer braided tube.
The flexible microwave ablation needle under ultrasound endoscope according to any one of claims 7 to 10, further comprising a sliding member, a connecting member, and a plurality of second temperature sensors, wherein the connecting member includes a sliding portion and a connecting portion. A plurality of deformed parts connected by the sliding part, the plurality of deformed parts are arranged at intervals along the circumferential direction of the sliding part, the sliding part is connected with the sliding part, and the sliding part is located between the inner tube and the inner tube; The outer tube slides and cooperates with the inner tube along the axial direction of the inner tube; the slide member slides with the handle, and when the connecting member slides relative to the inner tube, The deformed portion can extend from the inner tube and the outer tube and open outward in the radial direction of the inner tube, or the deformed portion can be retracted between the inner tube and the outer tube; Each said deformation part is provided with at least one second temperature sensor.
The flexible microwave ablation needle under ultrasound endoscope according to claim 11, wherein the sliding portion is sleeved outside the inner tube.
The flexible microwave ablation needle under ultrasound endoscope according to claim 11 or 12, characterized in that: the sliding portion is provided with a braided tube, and a plurality of the deformed portions are knitted with the braided tube as a whole.
The flexible microwave ablation needle under ultrasound endoscope according to any one of claims 1-13, wherein the handle comprises a first handle, a telescopic handle, and a second handle connected in sequence, and the telescopic handle and the The first handle or / and the second handle slide along the axial direction of the radio-frequency coaxial cable; the radio-frequency coaxial connector is disposed on the first handle, and the telescopic handle is provided with a through hole. A first through hole at both ends in the length direction of the telescopic handle, a second handle provided with a second through hole penetrating through both ends in the length direction of the second handle, the RF coaxial cable, the capillary tube And one end of the inner tube is connected to the first handle, and the radio frequency coaxial cable, the capillary tube, and the other end of the inner tube pass through the first through hole and the second through hole in order. An end of the second through-hole far from the first through-hole is extended.
The flexible microwave ablation needle under ultrasound endoscope according to claim 14, wherein the telescopic handle is slidably connected to the first handle.
The flexible microwave ablation needle under ultrasound endoscope according to claim 14 or 15, wherein a locking device is provided between the telescopic handle and the first handle to prevent the two from sliding relative to each other.
The flexible microwave ablation needle under ultrasound endoscope according to claim 16, wherein the locking device comprises a snap ring connected to the first handle, a bump is provided on the snap ring, and the telescopic A snap groove is provided on the outer peripheral surface of the handle, and the snap ring can be deformed in a radial direction so that the projection is engaged in the snap groove, thereby restricting the first handle from sliding relative to the telescopic handle; or The protrusion is separated from the card slot, so that the first handle and the telescopic handle can slide relative to each other.
The flexible microwave ablation needle under ultrasound endoscope according to any one of claims 15-17, wherein the first handle is provided with a hollow area, and the telescopic handle is inserted into the hollow area and can be opposite to each other. Sliding on the first handle.
The flexible microwave ablation needle under ultrasound endoscope according to any one of claims 1 to 18, characterized in that: the handle is provided with an isolation cavity, and the isolation cavity comprises a water inlet cavity and a water outlet cavity separated from each other, The capillary tube communicates with the water inlet pipe through the water inlet cavity, and the drainage channel communicates with the water outlet pipe through the water outlet cavity.
The flexible microwave ablation needle under ultrasound endoscope according to any one of claims 1 to 19, wherein the microwave radiation antenna is a triangular pyramid antenna, a bevel antenna, or a conical antenna.