WO2020015105A1 - 包含hppd抑制剂类除草剂的二元除草组合物及其应用 - Google Patents

包含hppd抑制剂类除草剂的二元除草组合物及其应用 Download PDF

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WO2020015105A1
WO2020015105A1 PCT/CN2018/105272 CN2018105272W WO2020015105A1 WO 2020015105 A1 WO2020015105 A1 WO 2020015105A1 CN 2018105272 W CN2018105272 W CN 2018105272W WO 2020015105 A1 WO2020015105 A1 WO 2020015105A1
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herbicidal composition
methyl
hppd inhibitor
binary
hppd
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PCT/CN2018/105272
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English (en)
French (fr)
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金涛
赵德
彭学岗
张景远
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青岛清原化合物有限公司
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Publication of WO2020015105A1 publication Critical patent/WO2020015105A1/zh

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M21/00—Apparatus for the destruction of unwanted vegetation, e.g. weeds
    • A01M21/04—Apparatus for destruction by steam, chemicals, burning, or electricity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
    • A01N35/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical at least one of the bonds to hetero atoms is to nitrogen
    • A01N35/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical at least one of the bonds to hetero atoms is to nitrogen containing a carbon-to-nitrogen double bond
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N39/00—Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or, e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
    • A01N39/02—Aryloxy-carboxylic acids; Derivatives thereof
    • A01N39/04—Aryloxy-acetic acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/18—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with sulfur as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/20—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom three- or four-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2

Definitions

  • the invention belongs to the field of pesticides, and particularly relates to a binary herbicidal composition containing an HPPD inhibitor herbicide and its application.
  • Chemical weed control is the most economical and effective method for controlling weeds in farmland.
  • long-term continuous high-dose use of a single variety or single action chemical herbicide can easily cause problems such as resistance and evolution of weeds.
  • oxadiazone is a newly developed HPPD inhibitor herbicide for the treatment of stems and leaves of wheat field seedlings. It has excellent biological activity and can effectively control a variety of malignant weeds in wheat fields.
  • the chemical structural formula of ciclopirox is It belongs to the HPPD inhibitor.
  • HPPD enzyme By inhibiting the activity of the HPPD enzyme, the process of converting p-hydroxypyruvate to uromelic acid is blocked, resulting in the inability to synthesize tocopherols and plastid quinones, affecting the carotenoid synthesis in the target, and causing the leaves to turn white. Affect the normal progress of photosynthesis in plants, and eventually die completely.
  • Reasonable compounding or mixing of herbicide compounds has the advantages of expanding the weed spectrum, improving the control effect, delaying the occurrence and development of weed resistance and resistance, and is one of the most effective methods to solve the above problems. Therefore, there is an urgent need to develop a variety of herbicidal compositions with high safety, broad herbicidal spectrum, which can produce synergistic effects and solve the problem of resistant weeds.
  • the present invention provides a binary herbicidal composition comprising an HPPD inhibitor herbicide and its application.
  • the composition can effectively prevent weed problems such as hog weed, amaranth, yarrow in crop fields, Japanese nymphs, yarrow, thousands of gold, wild oats, brome, ramie and other weeds. Dosage, safety to crops, synergistic effects, and resistance to weeds.
  • a binary herbicidal composition comprising an HPPD inhibitor herbicide, comprising an herbicidally effective amount of active ingredient A and active ingredient B, wherein,
  • the active ingredient A is selected from one or more of the following HPPD inhibitor-type herbicide compounds: HPPD inhibitor-type herbicides: diazoxynone (CAS number: 1622908-18-2), ciclopirox (CAS) No .: 1855929-45-1) and / or its derivatives
  • the active ingredient B is selected from one or more of the following compounds: herbicide (CAS number: 25059-80-7), flupronil (CAS number: 134605-64-4), inulinone (CAS No. 133220-30-1), bixlozone (CAS number: 81777-95-9), clomazone (CAS number: 81777-89-1), dichloroquinolinone (CAS number: 130901-36-8 ), Quinacridone (CAS number: 1639426-14-4), oxazosin (CAS number: 256412-89-2), cyprobenone (CAS number: 139001-49-3), acetodim (CAS number: 99129-21-2), grass grass (CAS number: 51338-27-3), imazapyr (CAS number: 81335-77-5), and / or its salts / esters and other derivatives.
  • herbicide CAS number: 25059-80-7
  • flupronil CAS number: 134605-64-4
  • inulinone CAS No. 133220-30
  • the common name of the active compound all conventional derivatives, such as esters and salts, as well as isomers, especially optical isomers, in particular One or more commercially available forms. If the common name indicates an ester or salt, all other conventional derivatives are also included in each case, such as other esters and salts, free acids and neutral compounds, and isomers, especially optical isomers, especially It is one or more commercially available forms.
  • the given chemical name of a compound represents at least one compound that is covered by a common name, and is generally a preferred compound.
  • salts also include salts formed by the exchange of a cation with a hydrogen atom in a sulfonamide group.
  • the salt of the compound is preferably in the form of a respective alkali metal salt, alkaline earth metal salt or ammonium salt, preferably in the form of a respective alkali metal salt, more preferably in the form of a respective sodium or potassium salt, Most preferred is the form of the respective sodium salt.
  • the weight ratio of A and B is 1 to 200: 200 to 1 and 1 to 150: 150 to 1; preferably 1 to 120: 120 to 1 and 1 to 100: 100 to 1; more preferably 1 to 80:80 to 1 and 1 to 50: 50 to 1; more preferably 1 to 30: 30 to 1 and 1 to 10: 10 to 1.
  • the mass percentage of A and B in the herbicidal composition accounts for 1-95% of the total, preferably 10-80%.
  • the herbicidal composition further includes a conventional auxiliary agent, and the conventional auxiliary agent includes a carrier and a surfactant.
  • carrier herein means an organic or inorganic, natural or synthetic substance. They facilitate the application of the active ingredient, the carriers are generally inert and must be agriculturally acceptable, especially by the treated plants.
  • the carrier can be solid, such as clay, natural or synthetic silicate, silica, resin, wax, solid fertilizer, etc .; or liquid, such as water, alcohols, ketones, petroleum fractions, aromatic or wax hydrocarbons, chlorine Hydrocarbon replacement, liquefied gas, etc.
  • the surfactant may include an emulsifier, a dispersant, or a wetting agent, and it may be ionic or non-ionic.
  • examples which may be mentioned are salts of polyacrylic acid, lignin sulfonates, phenol sulfonic acids or naphthalene sulfonic acids, ethylene oxide with aliphatic alcohols or with aliphatic acids or with aliphatic amines and substituted phenols (particularly Is an alkylphenol or an arylphenol) polymer, a sulfosuccinate, a taurine derivative (especially an taurine alkyl ester), and a phosphate of an alcohol or a polyhydroxyethylated phenol, Alkyl sulfonates, alkylaryl sulfonates, alkyl sulfates, lauryl ether sulfates, fatty alcohol sulfates, and sulfated cetyl-, hepta-
  • composition may also contain various other components such as protective colloids, adhesives, thickeners, thixotropic agents, penetrants, stabilizers, chelating agents, dyes, colorants, and polymers.
  • the binary composition of the present invention can be mixed with the following active substances, for example, "World Encyclopedia of New Pesticide Technology", China Agricultural Science and Technology Press, 2010.9 and the known substances cited in the literature cited here.
  • the herbicide active substances mentioned below (note: the name of the compound, or the common name according to the International Organization for Standardization (ISO), or the chemical name, with a code when appropriate): acetochlor, butachlor, Alachlor, Promethachlor, Metolachlor, Prometachlor, Promechlor, Toxachlor, Chlortochlor, Naproxyl, R-Lonaphal , Fenoxadi, fenoxyfen, fenflufen, chlorfenapyr, flubutyramide, bromobutyramide, methacetamide, high-efficiency methacetamide, ethoxylate Acetochlor, fluoxadi, methachlor, imazapyr, clomazone, high-performance dicamba,
  • the herbicidal composition further includes at least one safener selected from:
  • Dichlorophenylpyrazoline-3-carboxylic acid (S1) compounds and preferred compounds are, for example, 1- (2,4-dichlorophenyl) -5- (ethoxycarbonyl) -5-methyl Ethyl-2-pyrazoline-3-carboxylic acid ethyl ester (S1-1, mefenpyr-diethyl, PM, pages 594-595), as well as described in, for example, WO91 / 07874 and PM (page 594-595).
  • Dichlorophenylpyrazolecarboxylic acid derivatives are, for example, 1- (2,4-dichlorophenyl) -5-methylpyrazole-3-carboxylic acid ethyl ester (S1-2), 1- (2,4-dichlorophenyl) -5-isopropylpyrazole-3-carboxylic acid ethyl ester (S1-3), 1- (2,4-dichlorophenyl) -5- (1 1,1-Dimethyl-ethyl) pyrazole-3-carboxylic acid ethyl ester (S1-4), 1- (2,4-dichlorophenyl) -5-phenylpyrazole-3-carboxylic acid ethyl Esters (S1-5), and related compounds described in EP-A-333131 and EP-A-269806.
  • Triazolecarboxylic acid (S1) compounds and preferred compounds are, for example, fenchlorazole, that is, 1- (2,4-dichlorophenyl) -5-trichloromethyl- (1H) -1 , 2,4-triazole-3-carboxylic acid ethyl ester (S1-6) and related compounds (see EP-A-174562 and EP-A-346620).
  • 5-benzyl- or 5-phenyl-2-isooxazoline-3-carboxylic acids or 5,5-diphenyl-2-isooxazoline-3-carboxylic acids preferably
  • the compound is, for example, 5- (2,4-dichlorobenzyl) -2-isoxazoline-3-carboxylic acid ethyl ester (S1-7) or 5-phenyl-2-isooxazoline-3-carboxylic acid Ethyl Ester (S1-8) and related compounds described in WO91 / 08202, or 5,5-diphenyl-2-isooxazoline- described in patent application (WO-A-95 / 07897) Ethyl 3-carboxylate (S1-9, isoxadifen-ethyl) or 5,5-diphenyl-2-isoxazoline-3-carboxylic acid n-propyl ester (S1-10) Or 5- (4-fluorophenyl) -5-phenyl
  • S2 8-quinolinoxyacetic acid (S2) compounds, preferably 1-methylhex-1-yl (5-chloro-8-quinolinoxy) acetate (S2-1, cloquintocet- mexyl), such as PM (p.195-196), (1,3-dimethylbut-1-yl) (5-chloro-8-quinolinyloxy) acetate (S2-2), 4- Allyloxybutyl (5-chloro-8-quinolinoxy) acetate (S2-3), 1-allyloxyprop-2-yl (5-chloro-8-quinolinoxy Methyl) acetate (S2-4), (5-chloro-8-quinolinyloxy) ethyl acetate (S2-5), (5-chloro-8-quinolinyloxy) acetic acid methyl ester (S2- 6), (5-chloro-8-quinolinoxy) allyl acetate (S2-7), 2- (2-propyleneiminooxy) -1-eth
  • 5-chloro-8-quinolinyloxy) malonic acid compounds and preferred compounds are, for example, (5-chloro-8-quinolinyloxy) malonic acid diethyl ester, (5-chloro-8 -Quinolinoxy) diallyl malonate, (5-chloro-8-quinolinoxy) -methyl malonate and related compounds described in EP-A-0582198.
  • phenoxyacetic acid phenoxypropionic acid or aromatic carboxylic acid active compounds, such as 2,4-dichlorophenoxyacetic acid (and esters) (2,4-D), 4-chloro-2- Methylphenoxypropionate (2-methyl-4-chloropropionic acid (mecoprop)), MCPA or 3,6-dichloro-2-methoxybenzoic acid (and esters) (dicamba) .
  • Corn seed dressings are called safeners to prevent damage from thiourethane herbicides
  • the safener is preferably dibenzoxazolic acid (CAS: 163520-33-0), cyprosulfamide (CAS: 221667-31-8), pyrazolidin (CAS: 135590-91-9), and detoxification quinone (CAS) : 99607-70-2), gibberellic acid (CAS: 7-06-5), furilazole (CAS: 121776-33-8), metcamifen (CAS: 129531-12-0).
  • composition of the present invention can be diluted or used directly by the user before use.
  • the formulation can be prepared by ordinary processing methods, that is, after mixing the active substance with a liquid solvent or a solid carrier, and then adding one or more of a surfactant such as a dispersant, a stabilizer, a wetting agent, a binder, and an antifoaming agent. Species.
  • Specific formulations of the herbicidal composition are dispersible oil suspensions, water suspensions, suspoemulsions, wettable powders, emulsifiable concentrates, water-dispersible granules (dry suspensions), water emulsions, and microemulsions.
  • compositions of the present invention can be mixed with solid and liquid additives conventionally used in formulations of the prior art.
  • the invention also provides an application of the binary herbicidal composition for controlling weeds in crops, and a method for controlling unwanted plant growth, which comprises applying the binary herbicidal composition to plants, Plant parts, plant seeds or areas where plants grow, preferably for selective control of weeds in crops.
  • composition of the present invention can be applied to the leaves of the plant to be treated by spraying, that is, to the weeds, especially to the surface of weeds that are harmful to crop growth or easily affected by the weeds.
  • the herbicidal composition of the present invention When the herbicidal composition of the present invention is applied, an unexpected synergistic effect is obtained, and the herbicidal activity is more significant than the expected sum of the activities using a single herbicide, and the activity of a single herbicide.
  • the synergistic effects are reduced application rates, wider weed control spectrum, faster and longer-lasting weed control, these characteristics are required during weed control practice.
  • these new compositions are clearly superior to existing herbicides, achieving reduced use and being more environmentally friendly.
  • composition of the present invention is environment-friendly and easily degrades in the environment, and is suitable for various crop fields.
  • the herbicidal composition of the present invention has low cost and convenient use, and its promotion and application has huge economic and social benefits.
  • dispersable oil suspending agent processing equipment mixing kettle, colloid mill, sand mill, shearing machine, etc.
  • the above-mentioned dispersible oil suspending agent processing process Put all the materials into the mixing tank, mix and pass the colloid mill, then enter the sand mill three-stage sand mill, and finally cut it uniformly in the shearing machine. After passing the test, transfer Fill to the tank.
  • Pork scallion, amaranth, yarrow, Japanese look Mai Niang, yarrow, Qianjin gold were collected from Xinghua, Jiangsu, wild oats from Henan Zhumadian, brome and ramie from Shandong.
  • the above weeds were cultivated in a pot method. They were placed in plastic enamel dishes with 180 ⁇ 140mm plastic nutrition bowls, and the surface soil (4/5 places) collected from the farmland was air-dried and sieved. The initial humidity of the soil was controlled at 20%. The grains are full and uniform, soaked in warm water at 25 ° C for 6 hours, and germinated in a 28 ° C biochemical incubator (dark). The freshly weed seeds that are just white are evenly placed on the soil surface, and then covered with soil 0.5 -1cm.
  • 3WP-2000 walking spray tower Nanjing Agricultural Machinery Research Institute, Ministry of Agriculture. GA10 type ten thousandth electronic balance (Germany); ZDR2000 intelligent data logger (Hangzhou Zeda Instrument Co., Ltd.); SPX intelligent biochemical incubator (Ningbo Jiangnan Instrument Factory)
  • the required active ingredient B is purchased by the reagent company, and A is produced by the company.
  • the original drugs all use acetone as the solvent, and are diluted with 0.1% emulsifier Tween-80 aqueous solution.
  • Each treatment was repeated 4 times, each treatment was 3 pots, and 20 weed seeds were sown in each pot, for a total of 60 plants per treatment.
  • the trial shared the drug once. When the weeds are in the 1-leaf stage, we need to maintain 15 plants of weeds in each pot and 45 plants per treatment, and then continue to grow to 2-3 leaves for treatment.
  • the cultured test material was evenly placed on a platform with an area of 0.5 m 2 , and sprayed with the stems and leaves of a 3WP-2000 walking spray tower, and the spray volume was 30 kg / ha.
  • Spray pressure is 0.3MPa. After spraying all the chemicals, close the gas valve. After 30 seconds, open the spray tower door and remove the nutrition bowl. Then open the air valve, spray 50mL of clean water, and clean the spray tube.
  • Absolute number survey method was used to cut the whole seedlings of surviving weeds along the soil surface with a blade, and the fresh weeds were weighed with an analytical balance. For dead weeds, the fresh weight is zero.
  • E-E0 values greater than 10% are synergistic effects, less than -10% are antagonistic effects, and between -10% and 10% are additive effects. And determine the optimal ratio according to the actual control effect, the characteristics of the herbicide, the balance of the formula and other factors.
  • X is the fresh weight inhibition rate when the amount of active ingredient A is P
  • Y is the fresh weight inhibition rate when the amount of active ingredient B is Q.
  • Pork scallion, amaranth, yarrow, Japanese look Mai Niang, yarrow, Qianjin gold were collected from Xinghua, Jiangsu, wild oats from Henan Zhumadian, brome and ramie from Shandong.
  • the required active ingredients B are all commercially available drugs, and A is produced by the company.
  • the original drugs all use acetone as the solvent, and are diluted with 0.1% emulsifier T-80 aqueous solution.
  • Each treatment was repeated 4 times, each treatment was 3 pots, and 30 weed seeds were sown in each pot.
  • a field weed effect test was performed using the herbicide composition prepared in Examples 1) to 24).
  • Soil treatment Before the weeds germinate, use a hand sprayer with a water volume of 45 kg / 667m 2 , and evenly spray the soil surface.
  • test agents and dosages are shown in Table 25.
  • the plot area is 50 square meters, and each treatment is repeated 4 times. See Table 25 for the control effect of the investigation 45 days after the application.
  • Example 21 OD 127.5 94.5
  • Example 22 OD 127.5 98.1
  • Example 23 OD 465 94.9
  • Example 24 OD 165 98.1 10% oxadiazon OD Zh 30 34.5 12% ciclopirox OD Zh 135 57.3 10% Herbicide OD Zh 150 25.3 0.5% Flupronil OD Zh 7.5 33.1 5% indone OD Zh 75 37.2 5% bixlozoneOD Zh 75 41.4 30% clomazone OD Zh 450 37.5 20%
  • Dichloroquinolinone OD Zh 300 26.4 1% quinacetone OD Zh 15 24.2 4% oxazolyl OD Zh 60 31.5 2.5% cycloprofenone OD Zh 37.5 22.6 2.5% methotrione OD Zh 37.5 24.7 25% grass grass OD Zh 375 25.6 5% imazapyr OD Zh 75 26.1
  • the present invention unexpectedly found that the composition is used to control weeds such as porcupine burdock, amaranth, yarrow, Japanese maidenhair, yarrow, Qianjin, wild oats, brome, ramie , Has a surprising and unexpected synergistic effect.
  • This synergistic effect is more significant at low doses, which can reduce the amount of medicine used, reduce environmental pollution, and rationally reduce agricultural costs.
  • ACCase inhibitor-resistant weeds are highly effective and have good application prospects.

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Abstract

一种包含HPPD抑制剂类除草剂的二元除草组合物及其应用。所述组合物包括除草有效量的活性成分A和B，其中，A选自以下HPPD抑制剂类除草剂化合物中的一种或多种：HPPD抑制剂类除草剂：双唑草酮、环吡氟草酮和/或其盐/酯等衍生物；B选自以下化合物中的一种或多种：草除灵、氟丙嘧草酯、茚草酮、bixlozone、异噁草松、二氯喹啉草酮、喹草酮、噁唑酰草胺、环苯草酮、烯草酮、禾草灵、咪草烟和/或其盐/酯等衍生物。该组合物能有效防除作物田中的猪殃殃、荠菜、稗草、日本看麦娘、菵草、千金子、野燕麦、雀麦、苘麻等杂草问题，具有扩大杀草谱、减少施用量、对作物安全、能够产生增效作用并解决抗性杂草等特点。

Description

包含HPPD抑制剂类除草剂的二元除草组合物及其应用 技术领域
本发明属于农药领域，具体涉及一种包含HPPD抑制剂类除草剂的二元除草组合物及其应用。
背景技术
化学除草是农田杂草防除中最为经济、有效的手段，但长期连续高剂量地使用单一品种或单一作用方式的化学除草剂，容易造成杂草耐药和抗性演化等问题。
双唑草酮化学结构式为
Figure PCTCN2018105272-appb-000001
是新研发的小麦田苗后茎叶处理的HPPD抑制剂类除草剂，具有优异的生物活性，可以有效防除小麦田多种恶性杂草。
环吡氟草酮化学结构式为
Figure PCTCN2018105272-appb-000002
属于HPPD抑制剂，通过抑制HPPD酶的活性，使对羟基丙酮酸转化为尿黑酸过程受阻，从而导致生育酚及质体醌无法正常合成，影响靶标体内类胡萝卜素合成，导致叶片发白，影响植物体内光合作用的正常进行，最终彻底死亡。
除草剂化合物的合理复配或混配具有扩大杂草谱、提高防除效果、延缓杂草耐药性和抗药性的发生与发展等优点，是解决上述问题的最为有效的方法之一。因此生产上亟需开发安全性高、杀草谱广、能够产生增效作用并解决抗性杂草问题的除草组合物品种。
发明内容
为解决现有技术中存在的上述问题，本发明提供一种包含HPPD抑制剂类除草剂的二元除草组合物及其应用。该组合物能有效防除作物田中的猪殃殃、荠菜、稗草、日本看麦娘、菵草、千金子、野燕麦、雀麦、苘麻等杂草问题，具有扩大杀草谱、减少施用量、对作物安全、能够产生增效作用并解决抗性杂草等特点。
一种包含HPPD抑制剂类除草剂的二元除草组合物，包括除草有效量的活性成分A和活性成分B，其中，
活性成分A选自以下HPPD抑制剂类除草剂化合物中的一种或多种：HPPD抑制剂类除 草剂：双唑草酮(CAS号：1622908-18-2)、环吡氟草酮(CAS号：1855929-45-1)和/或其盐/酯等衍生物；
活性成分B选自以下化合物中的一种或多种：草除灵(CAS号：25059-80-7)、氟丙嘧草酯(CAS号：134605-64-4)、茚草酮(CAS号：133220-30-1)、bixlozone(CAS号：81777-95-9)、异噁草松(CAS号：81777-89-1)、二氯喹啉草酮(CAS号：130901-36-8)、喹草酮(CAS号：1639426-14-4)、噁唑酰草胺(CAS号：256412-89-2)、环苯草酮(CAS号：139001-49-3)、烯草酮(CAS号：99129-21-2)、禾草灵(CAS号：51338-27-3)、咪草烟(CAS号：81335-77-5)和/或其盐/酯等衍生物。
在本说明书的上下文中，如果使用活性化合物的通用名称的缩写形式，则在每种情况下包括所有的常规衍生物，例如酯和盐，以及异构体，特别是光学异构体，特别是一种或多种市售形式。如果通用名称表示酯或盐，则在每种情况下还包括所有其他的常规衍生物，例如其他的酯和盐、游离酸和中性化合物，以及异构体，特别是光学异构体，特别是一种或多种市售形式。给出的化合物的化学名称表示至少一种被通用名称涵盖的化合物，通常是优选的化合物。在磺酰胺如磺酰脲的情况下，盐还包括通过阳离子与磺酰胺基团中的氢原子交换而形成的盐。
在本发明的上下文中，化合物的盐优选为各自的碱金属盐、碱土金属盐或铵盐的形式，优选为各自的碱金属盐的形式，更优选为各自的钠盐或钾盐的形式，最优选为各自的钠盐的形式。
A、B的重量比为1～200:200～1和1～150:150～1；优选为1～120:120～1和1～100:100～1；更优选为1～80:80～1和1～50:50～1；进一步优选为1～30:30～1和1～10:10～1。
所述除草组合物中A、B的质量百分含量占总量的1-95％，优选10-80％。
所述除草组合物中还包含常规助剂，所述常规助剂包括载体、表面活性剂。
本文中的术语“载体”表示一种有机或无机、天然或合成的物质。它们有助于活性成分的施用，该载体一般是惰性的且必须是农业上可接受的，特别是被处理的植物所接受。载体可以是固体的，如陶土、天然或合成的硅酸盐、二氧化硅、树脂、蜡、固体肥料等；或者液体的，如水、醇类、酮类、石油馏分、芳烃或蜡烃、氯代烃、液化气等。
表面活性剂可包括乳化剂、分散剂或润湿剂，它可以是离子型或非离子型的。可提及的实例是聚丙烯酸的盐、木质素磺酸盐、苯酚磺酸或萘磺酸的盐、环氧乙烷与脂肪族醇或与脂族酸或与脂肪族胺与取代苯酚(特别是烷基苯酚或芳基苯酚)的聚合物、磺基琥珀酸盐、牛磺酸衍生物(特别是牛磺酸烷脂)及醇的磷酸酯或多羟乙基化的苯酚的磷酸酯、烷基磺酸盐、烷基芳基磺酸盐、烷基硫酸盐、月桂基醚硫酸盐、脂肪醇硫酸盐，以及硫酸化十六-、十七- 和十八烷醇以及硫酸化脂肪醇乙二醇醚，此外还有萘或萘磺酸与苯酚和甲醛的缩合物、聚氧乙烯辛基苯基醚、乙氧基化异辛基酚、辛基酚或壬基酚、烷基苯基聚乙二醇醚、三丁基苯基聚乙二醇醚、三硬脂基苯基聚乙二醇醚、烷基芳基聚醚醇、醇和脂肪醇/氧化乙烯缩合物、乙氧基化蓖麻油、聚氧乙烯烷基醚、乙氧基化聚氧丙烯、月桂醇聚乙二醇醚缩醛、山梨醇酯、木素亚硫酸盐废液，以及蛋白质、变性蛋白、多糖(例如甲基纤维素)、疏水改性淀粉、聚乙烯醇、聚羧酸盐、聚烷氧基化物、聚乙烯胺、聚乙烯吡咯烷酮及其共聚物。至少需要一种表面活性剂存在，以有利于活性成分在水中的分散并有利于使它们能正确地施用于植物。
上述组合物也可含有各种其他的组分，如保护胶体、粘合剂、增稠剂、触变剂、渗透剂、稳定剂、螯合剂、染料、着色剂和聚合物。
另外，本发明的二元组合物可以与以下活性物质混合，例如《世界农药新品种技术大全》，中国农业科学技术出版社，2010.9和这里引用的文献中的已知物质。例如以下提到的除草剂活性物质，(备注:化合物的名称，或者为根据国际标准化组织(ISO)的普通名称，或者为化学名称，适当的时候有代号):乙草胺、丁草胺、甲草胺、异丙草胺、异丙甲草胺、精异丙甲草胺、丙草胺、毒草胺、克草胺、萘丙酰草胺、R-左旋萘丙酰草胺、敌稗、苯噻酰草胺、双苯酰草胺、吡氟酰草胺、杀草胺、氟丁酰草胺、溴丁酰草胺、二甲噻草胺、高效二甲噻草胺、乙氧苯草胺、氟噻草胺、甲氧噻草胺、吡草胺、异恶草胺、高效麦草伏甲酯、高效麦草伏丙酯、二丙烯草胺、烯草胺、丁酰草胺、环丙草胺、氟磺酰草胺、庚酰草胺、异丁草胺、丙炔草胺、特丁草胺、二甲苯草胺、二甲草胺、落草胺、三甲环草胺、氯甲酰草胺、炔苯酰草胺、戊酰苯草胺、卡草胺、新燕灵、三环赛草胺、丁烯草胺、牧草胺、苄草胺、醌萍胺、苯氟磺胺、萘丙胺、乙酰甲草胺、萘草胺、噻草胺、吡氰草胺、苯草多克死、草克乐、氯酞亚胺、丁脒胺、氟吡草胺、莠去津、西玛津、扑草净、氰草净、西草净、莠灭净、扑灭津、异丙净、氟草净、特丁净、特丁津、三嗪氟草胺、环丙津、甘扑津、草达津、扑灭通、西玛通、叠氮净、敌草净、异戊乙净、环丙青津、灭莠津、另丁津、仲丁通、特丁通、甲氧丙净、氰草净、抑草津、可乐津、莠去通、灭草通、甘草津、三聚氰酸、Indaziflam、绿磺隆、甲磺隆、苄嘧磺隆、氯嘧黄隆、苯磺隆、噻磺隆、吡嘧黄隆、甲基二磺隆、甲基碘磺隆钠盐、甲酰氨基嘧磺隆、醚磺隆、醚苯磺隆、甲嘧磺隆、烟嘧磺隆、胺苯磺隆、酰嘧磺隆、乙氧嘧磺隆、环丙嘧磺隆、砜嘧磺隆、四唑嘧磺隆、啶嘧黄隆、单嘧磺隆、单嘧磺酯、氟唑磺隆、氟啶嘧磺隆、氟吡嘧磺隆、环氧嘧磺隆、唑吡嘧磺隆、氟嘧磺隆、丙苯磺隆、三氟丙磺隆、磺酰磺隆、三氟啶磺隆、氟胺磺隆、三氟甲磺隆、甲磺隆钠盐、氟吡磺隆、甲硫嘧磺隆、嘧苯胺磺隆、Propyrisulfuron(丙嗪嘧磺隆)、嗪吡嘧磺隆、三氟羧草醚、氟磺胺草醚、乳氟禾草灵、乙羧氟草醚、乙氧氟草醚、草枯醚、苯草醚、氯氟草醚乙酯、甲羧除草醚、三氟甲草醚、 甲氧除草醚、三氟硝草醚、氟化除草醚、氟呋草醚、除草醚、甲草醚、二甲草醚、氟酯肟草醚、氟草醚酯、Halosafen、绿麦隆、异丙隆、利谷隆、敌草隆、莎扑隆、氟草隆、苯噻隆、甲基苯噻隆、苄草隆、磺噻隆、异恶隆、特丁噻草隆、炔草隆、氯溴隆、甲基杀草隆、酰草隆、甲氧杀草隆、溴谷隆、甲氧隆、绿谷隆、灭草隆、环草隆、非草隆、氟硫隆、草不隆、枯草隆、草完隆、异草完隆、环莠隆、噻氟隆、丁噻隆、枯莠隆、对氟隆、甲胺噻唑隆、隆草特、三甲异脲、恶唑隆、Monisouron、Anisuron、Methiuron、Chloreturon、四氟隆、甜菜宁、甜菜宁-乙酯、甜菜安、磺草灵、特草灵、燕麦灵、苯胺灵、氯苯胺灵、二氯苄草酯、灭草灵、氯炔灵、Carboxazole、Chlorprocarb、Fenasulam、BCPC、CPPC、Carbasulam、丁草特、禾草丹、灭草猛、禾草特、野麦畏、哌草丹、禾草畏、稗草丹、环草敌、燕麦敌、菌达灭、乙硫草特、坪草丹、克草猛、苄草丹、仲草丹、硫烯草丹、草灭散、Isopolinate、Methiobencarb、2,4-D异辛酯丁酯、2甲4氯钠、2,4-D异辛酯异辛酯、2甲4氯异辛酯、2,4-D异辛酯钠盐、2,4-D异辛酯二甲胺盐、2甲4氯乙硫酯、2甲4氯、2,4-D异辛酯丙酸、高2,4-D异辛酯丙酸盐、2,4-D异辛酯丁酸、2甲4氯丙酸、2甲4氯丙酸盐、2甲4氯丁酸、2,4,5-涕、2,4,5-涕丙酸、2,4,5-涕丁酸、2甲4氯胺盐、麦草畏、抑草蓬、伐草克、赛松、三氯苯酸、氨二氯苯酸、甲氧三氯苯酸、禾草灵、吡氟禾草灵、精吡氟禾草灵、氟吡甲禾灵、高效吡氟氯禾灵、喹禾灵、精喹禾灵、恶唑禾草灵、精恶唑禾草灵、喔草酯、氰氟草酯、恶唑酰草胺、炔草酯、噻唑禾草灵、炔禾灵、羟戊禾灵、三氟禾草肟、异恶草醚、百草枯、敌草快、安磺灵、乙丁烯氟灵、异丙乐灵、甲磺乐灵、环丙氟灵、氨基丙氟灵、乙丁氟灵、氯乙氟灵、氨基乙氟灵、地乐灵、氯乙地乐灵、Methalpropalin、丙硝酚、草甘膦、莎稗膦、草铵膦、甲基胺草磷、草硫膦、哌草膦、双丙氨膦、地散磷、抑草磷、蔓草磷、伐垅磷、双甲胺草磷、草特磷、咪唑烟酸、咪唑乙烟酸、咪唑喹啉酸、甲氧咪草烟、甲氧咪草烟铵盐、甲咪唑烟酸、咪草酯、氯氟吡氧乙酸、氯氟吡氧乙酸异辛酯、二氯吡啶酸、氨氯吡啶酸、三氯吡氧乙酸、氟硫草定、卤草定、三氯吡啶酚、噻草啶、氟啶草酮、氯氨吡啶酸、氟吡草腙、三氯吡氧乙酸丁氧基乙酯、Cliodinate、稀禾啶、烯草酮、噻草酮、禾草灭、环苯草酮、丁苯草酮、肟草酮、吡喃草酮、Buthidazole、嗪草酮、环嗪酮、苯嗪草酮、乙嗪草酮、Ametridione、Amibuzin、溴苯腈、辛酰溴苯腈、辛酰碘苯腈、碘苯腈、敌草腈、二苯乙腈、双唑草腈、羟敌草腈、Iodobonil、唑嘧磺草胺、双氟磺草胺、五氟磺草胺、磺草唑胺、氯酯磺草胺、双氯磺草胺、啶磺草胺、氟草黄、双草醚、嘧啶肟草醚、环酯草醚、嘧草醚、嘧硫草醚、双环磺草酮、硝磺草酮、磺草酮、Tembotrione、Tefuryltrione、Bicyclopyrone、Ketodpiradox、异恶唑草酮、异恶氯草酮、Fenoxasulfone、Methiozolin、异丙吡草酯、吡草醚、吡唑特、野燕枯、苄草唑、吡草酮、吡氯草胺、Pyrasulfotole、苯唑草酮、Pyroxasulfone、唑草胺、氟胺草唑、杀草强、氨唑草酮、 唑啶草酮、氟唑草酮、甲磺草胺、Bencarbazone、双苯嘧草酮、氟丙嘧草酯、除草定、异草定、环草啶、特草定、Flupropacil、吲哚酮草酯、氟烯草酸、丙炔氟草胺、炔草胺、酞苄醚、Flumezin、五氯酚(钠)、地乐酚、特乐酚、特乐酯、戊硝酚、二硝酚、氯硝酚、地乐施、地乐特、丙炔恶草酮、恶草酮、环戊恶草酮、氟唑草胺、嗪草酸甲酯、四唑酰草胺、氟哒嗪草酯、杀草敏、溴莠敏、二甲达草伏、哒草醚、草哒酮、草哒松、哒草伏、Pyridafol、二氯喹啉酸、氯甲喹啉酸、苯达松、哒草特、恶嗪草酮、草除灵、异恶草酮、环庚草醚、异丙酯草醚、丙酯草醚、茚草酮、氯酸钠、茅草枯、三氯醋酸、一氯醋酸、六氯丙酮、四氟丙酸、牧草快、溴酚肟、三唑磺、灭杀唑、呋草酮、呋草磺、乙呋草磺、嘧草胺、氯酞酸、氟咯草酮、稗草稀、丙烯醛、苯草灭、灭草环、燕麦酯、噻二唑草胺、棉胺宁、羟草酮、甲氧苯酮、苯嘧磺草胺、氯酰草膦、三氯丙酸、Alorac、Diethamquat、Etnipromid、Iprymidam、Ipfencarbazone、Thiencarbazone-methyl、Pyrimisulfan、Chlorflurazole、Tripropindan、Sulglycapin、甲硫磺乐灵、Cambendichlor、环丙嘧啶酸、硫氰苯胺、解草酮、解草啶、解草安、解草唑、解草喹、解草腈、解草烷、解草胺腈、解草烯、吡唑解草酯、呋喃解草唑、肟草安、双苯噁唑酸、二氯丙烯胺、氟氯吡啶酯、DOW氯氟吡啶酯、UBH-509、D489，LS 82-556、KPP-300、NC-324、NC-330、KH-218、DPX-N8189、SC-0744、DOWCO535、DK-8910、V-53482、PP-600、MBH-001、KIH-9201、ET-751、KIH-6127和KIH-2023。
所述除草组合物进一步包括至少一种安全剂，其选自：
a)二氯苯基吡唑啉-3-羧酸(S1)类化合物，优选的化合物为例如1-(2,4-二氯苯基)-5-(乙氧基羰基)-5-甲基-2-吡唑啉-3-羧酸乙酯(S1-1，吡唑解草酯(mefenpyr-diethyl)，PM，第594-595页)，以及记载于例如WO91/07874和PM(第594-595页)中的相关化合物。
b)二氯苯基吡唑羧酸衍生物，优选的化合物为例如1-(2,4-二氯苯基)-5-甲基吡唑-3-羧酸乙酯(S1-2)、1-(2,4-二氯苯基)-5-异丙基吡唑-3-羧酸乙酯(S1-3)、1-(2,4-二氯苯基)-5-(1,1-二甲基-乙基)吡唑-3-羧酸乙酯(S1-4)、1-(2,4-二氯苯基)-5-苯基吡唑-3-羧酸乙酯(S1-5)，以及记载于EP-A-333131和EP-A-269806中的相关化合物。
c)三唑羧酸(S1)类化合物，优选的化合物为例如解草唑(fenchlorazole)，即1-(2,4-二氯苯基)-5-三氯甲基-(1H)-1,2,4-三唑-3-羧酸乙酯(S1-6)及相关化合物(参见EP-A-174562和EP-A-346620)。
d)5-苄基-或5-苯基-2-异噁唑啉-3-羧酸类或5,5-二苯基-2-异噁唑啉-3-羧酸类化合物，优选的化合物为例如5-(2,4-二氯苄基)-2-异噁唑啉-3-羧酸乙酯(S1-7)或5-苯基-2-异噁唑啉-3-羧酸乙酯(S1-8)及记载于WO91/08202中的相关化合物，或记载于专利申请(WO-A-95/07897)中的5,5-二苯基-2-异噁唑啉-3-羧酸乙酯(S1-9，双苯噁唑酸(isoxadifen-ethyl))或5,5-二苯基-2-异噁 唑啉-3-羧酸正丙酯(S1-10)或5-(4-氟苯基)-5-苯基-2-异噁唑啉-3-羧酸乙酯(S1-11)。
e)8-喹啉氧基乙酸(S2)类化合物，优选1-甲基己-1-基(5-氯-8-喹啉氧基)乙酸酯(S2-1，解毒喹(cloquintocet-mexyl)，如PM(第195-196页)，(1,3-二甲基丁-1-基)(5-氯-8-喹啉氧基)乙酸酯(S2-2)，4-烯丙基氧基丁基(5-氯-8-喹啉氧基)乙酸酯(S2-3)，1-烯丙基氧基丙-2-基(5-氯-8-喹啉氧基)乙酸酯(S2-4)，(5-氯-8-喹啉氧基)乙酸乙酯(S2-5)，(5-氯-8-喹啉氧基)乙酸甲酯(S2-6)，(5-氯-8-喹啉氧基)乙酸烯丙酯(S2-7)，2-(2-亚丙基亚氨基氧基)-1-乙基(5-氯-8-喹啉氧基)乙酸酯(S2-8)，2-氧代丙-1-基(5-氯-8-喹啉氧基)乙酸酯(S2-9)，以及记载于EP-A-86750、EP-A-94349和EP-A-191736或EP-A-0492366中的相关化合物。
f)(5-氯-8-喹啉氧基)丙二酸类化合物，优选的化合物为例如(5-氯-8-喹啉氧基)丙二酸二乙酯、(5-氯-8-喹啉氧基)丙二酸二烯丙酯、(5-氯-8-喹啉氧基)-丙二酸甲基乙酯和记载于EP-A-0582198中的相关化合物。
g)苯氧基乙酸、苯氧基丙酸或芳族羧酸类活性化合物，例如2,4-二氯苯氧基乙酸(和酯)(2,4-D)、4-氯-2-甲基苯氧基丙酸酯(2-甲-4-氯丙酸(mecoprop))、MCPA或3,6-二氯-2-甲氧基苯甲酸(和酯)(麦草畏(dicamba))。
h)嘧啶类活性化合物，例如“解草啶(fenclorim)”(PM，第386-387页)(＝4,6-二氯-2-苯基嘧啶)，
i)二氯乙酰胺类活性化合物，其常用作苗前安全剂(作用于土壤的安全剂)，例如“二氯丙烯胺(dichloromid)”(PM，第270-271页)(＝N,N-二烯丙基-2,2-二氯乙酰胺)，“AR-29148”(＝3-二氯乙酰基-2,2,5-三甲基-1,3-噁唑烷酮，购自Stauffer)，“解草嗪(benoxacor)”(PM，第74-75页)(＝4-二氯乙酰基-3,4-二氢-3-甲基-2H-1,4-苯并噁嗪)，“APPG-1292”(＝N-烯丙基-N[(1,3-二氧戊环-2-基)-甲基]二氯乙酰胺，购自PPG Industries)，“ADK-24”(＝N-烯丙基-N-[(烯丙基氨基羰基)-甲基]-二氯乙酰胺，购自Sagro-Chem)，“AAD-67”或“AMON4660”(＝3-二氯乙酰基-1-氧杂-3-氮杂-螺[4,5]癸烷，购自Nitrokemia或Monsanto)，“diclonon”或“ABAS145138”或“ALAB145138”(＝(＝3-二氯乙酰基-2,5,5-三甲基-1,3-二氮杂双环[4.3.0]壬烷，购自BASF)，和“furilazol”或“AMON13900”(参见PM，482-483)(＝(RS)-3-二氯乙酰基-5-(2-呋喃基)-2,2-二甲基噁唑烷酮)，
j)二氯丙酮衍生物类活性化合物，例如，“AMG191”(CAS登记号96420-72-3)(＝2-二氯甲基-2-甲基-1,3-二氧戊环，购自Nitrokemia)，
k)氧基亚氨基化合物类活性化合物，其被称为拌种材料，例如，“解草腈(oxabetrinil)”(PM，第689页)(＝(Z)-1,3-二氧戊环-2-基甲氧基亚氨基(苯基)乙腈)，其在拌种中称为安全剂，以防止异丙甲草胺(metolachlor)的损害，“氟草肟(fluxofenim)”(PM，第467-468页)(＝1-(4-氯苯 基)-2,2,2-三氟-1-乙酮O-(1,3-二氧戊环-2-基甲基)-肟，其在拌种中称为安全剂，以防止异丙甲草胺(metolachlor)的损害，和“解草胺腈(cyometrinil)”或“A-CGA-43089”(PM，第983页)(＝(Z)-氰基甲氧基亚氨基(苯基)乙腈)，其在拌种中称为安全剂，以防止异丙甲草胺(metolachlor)的损害，
l)噻唑羧酸酯类活性化合物，其被称为拌种材料，例如“解草安(flurazol)”(PM，第450-451页)(＝2-氯-4-三氟甲基-1,3-噻唑-5-羧酸苄酯)，其在拌种中被称为安全剂，以防止甲草胺(alachlor)和异丙甲草胺的损害，
m)萘二羧酸衍生物类活性化合物，其被称为拌种剂，例如“萘二甲酸酐”(PM，第1009-1010页)(＝1,8-萘二甲酸酐)，其在玉米拌种中称为安全剂，以防止硫代氨基甲酸酯除草剂的损害，
n)色满乙酸(chromaneaceticacid)衍生物类活性化合物，例如，“ACL304415”(CAS登记号31541-57-8)(＝2-84-羧基色满-4-基)乙酸，购自AmericanCyanamid)，
o)除了对有害植物具有除草作用外还对作物植物具有安全剂作用的活性化合物，例如，“哌草丹(dimepiperate)”或“AMY-93”(PM，第302-303页)(＝S-1-甲基-1-苯基乙基哌啶-1-硫代羧酸酯)，“杀草隆(daimuron)”或“ASK23”(PM，第247页)(＝1-(1-甲基-1-苯基乙基)-3-对甲苯基脲)，“苄草隆(cumyluron)”＝“AJC-940”(＝3-(2-氯苯基甲基)-1-(1-甲基-1-苯基-乙基)脲，参见JP-A-60087254)，“苯甲酮(methoxyphenon)”或“ANK049”(＝3,3'-二甲基-4-甲氧基-二苯甲酮)，“CSB”(＝1-溴-4-(氯甲基磺酰基)苯)(CAS登记号54091-06-4，购自Kumiai)。
所述安全剂优选双苯噁唑酸(CAS：163520-33-0)、cyprosulfamide(CAS：221667-31-8)、吡唑解草酯(CAS：135590-91-9)、解毒喹(CAS：99607-70-2)、赤霉酸(CAS：7-06-5)、furilazole(CAS：121776-33-8)、metcamifen(CAS：129531-12-0)中的一种或多种。
本发明的组合物可以由使用者在使用前经稀释或直接使用。其配制可由通常的加工方法制备，即将活性物质与液体溶剂或固体载体混合后，再加入表面活性剂如分散剂、稳定剂、湿润剂、粘合剂、消泡剂等中的一种或几种。
所述除草组合物的具体制剂为可分散油悬浮剂、水悬浮剂、悬乳剂、可湿性粉剂、乳油、水分散粒剂(干悬浮剂)、水乳剂、微乳剂。
简而言之，本发明的组合物可以和现有技术的配方中常规使用的固体和液体添加剂混合。
本发明还提供一种所述二元除草组合物在防治作物中杂草上的应用；以及提供一种防治不想要的植物生长的方法，其包括将所述二元除草组合物施用于植物、植物部位、植物种子或植物生长的区域，优选用于选择性防治作物中的杂草。
另外，本发明的组合物可通过喷雾的方法被施用于待处理植物叶片上，即施用于杂草，特别是对作物生长有害的杂草侵扰或易侵扰影响的表面上。
当施用本发明的除草组合物时，获得了预料不到的增效效果，并且除草活性比使用单个除草剂的活性预期总和，以及单个除草剂的活性更为显著。增效效果表现为施用量减少、更宽的杂草控制谱、除草作用更快、更持久，这些特性是杂草控制实践过程中所需要的。就所描述的特性来说，这些新组合物明显地优越于现有的除草剂，达到减量使用，对环境更友好。
本发明的增效除草组合物还具有下述优点:
(1)本发明的组合物为环境友好型，在环境中均易于降解，适用于多种作物田。
(2)本发明的除草组合物成本低、使用方便，其推广应用有巨大的经济效益和社会效益。
具体实施方式
下列实施例并非限制本发明，而只是用来说明本发明是如何实现的。对于某些杂草，这些实施例显示出特别显著的有效性。举例如下:
A)实施例
1. 12％双唑草酮·草除灵(2+10)可分散油悬浮剂
2％双唑草酮+10％草除灵+5％十二烷基苯磺酸钙+6％脂肪醇聚氧乙烯醚+5％蓖麻油氧乙烯醚+3.0％有机膨润土+2.5％气相法白炭黑+15％100#溶剂油+油酸甲酯补足
2. 5％双唑草酮·氟丙嘧草酯(4+1)可分散油悬浮剂
4％双唑草酮+1％氟丙嘧草酯+5％十二烷基苯磺酸钙+6％脂肪醇聚氧乙烯醚+5％蓖麻油氧乙烯醚+2.6％有机膨润土+2.5％气相法白炭黑+10％100#溶剂油+油酸甲酯补足
3. 7％双唑草酮·茚草酮(2+5)可分散油悬浮剂
2％双唑草酮+5％茚草酮+5％十二烷基苯磺酸钙+6％脂肪醇聚氧乙烯醚+5％蓖麻油氧乙烯醚+2.6％有机膨润土+2.5％气相法白炭黑+10％100#溶剂油+油酸甲酯补足
4. 7％双唑草酮·bixlozone(2+5)可分散油悬浮剂
2％双唑草酮+5％bixlozone+5％十二烷基苯磺酸钙+6％脂肪醇聚氧乙烯醚+5％蓖麻油氧乙烯醚+2.6％有机膨润土+2.5％气相法白炭黑+5％100#溶剂油+油酸甲酯补足
5. 32％双唑草酮·异噁草松(2+30)可分散油悬浮剂
2％双唑草酮+30％异噁草松+5％十二烷基苯磺酸钙+6％脂肪醇聚氧乙烯醚+5％蓖麻油氧乙烯醚+3.0％有机膨润土+2.0％气相法白炭黑+20％100#溶剂油+油酸甲酯补足
6. 22％双唑草酮·二氯喹啉草酮(2+20)可分散油悬浮剂
2％双唑草酮+20％二氯喹啉草酮+5％十二烷基苯磺酸钙+6％脂肪醇聚氧乙烯醚+5％蓖麻油氧乙烯醚+1.6％有机膨润土+1.6％气相法白炭黑+20％100#溶剂油+油酸甲酯补足
7. 3％双唑草酮·喹草酮(2+1)可分散油悬浮剂
2％双唑草酮+1％喹草酮+5％十二烷基苯磺酸钙+6％脂肪醇聚氧乙烯醚+5％蓖麻油氧乙烯 醚+3.0％有机膨润土+2.2％气相法白炭黑+6％100#溶剂油+油酸甲酯补足
8. 6％双唑草酮·噁唑酰草胺(2+4)可分散油悬浮剂
2％双唑草酮+4％噁唑酰草胺+5％十二烷基苯磺酸钙+6％脂肪醇聚氧乙烯醚+5％蓖麻油氧乙烯醚+3.0％有机膨润土+2.6％气相法白炭黑+6％100#溶剂油+油酸甲酯补足
9. 4.5％双唑草酮·环苯草酮(2+2.5)可分散油悬浮剂
2％双唑草酮+2.5％环苯草酮+5％十二烷基苯磺酸钙+6％脂肪醇聚氧乙烯醚+5％蓖麻油氧乙烯醚+2.6％有机膨润土+2.6％气相法白炭黑+6％100#溶剂油+油酸甲酯补足
10. 4.5％双唑草酮·烯草酮(2+2.5)可分散油悬浮剂
2％双唑草酮+2.5％烯草酮+5％十二烷基苯磺酸钙+6％脂肪醇聚氧乙烯醚+5％蓖麻油氧乙烯醚+3.0％有机膨润土+2.5％气相法白炭黑+6％100#溶剂油+油酸甲酯补足
11. 27％双唑草酮·禾草灵(2+25)可分散油悬浮剂
2％双唑草酮+25％禾草灵+5％十二烷基苯磺酸钙+6％脂肪醇聚氧乙烯醚+5％蓖麻油氧乙烯醚+3.0％有机膨润土+2.5％气相法白炭黑+20％100#溶剂油+油酸甲酯补足
12. 7％双唑草酮·咪草烟(2+5)可分散油悬浮剂
2％双唑草酮+5％咪草烟+5％十二烷基苯磺酸钙+6％脂肪醇聚氧乙烯醚+5％蓖麻油氧乙烯醚+3.0％有机膨润土+2.5％气相法白炭黑+20％100#溶剂油+油酸甲酯补足
13.环吡氟草酮·草除灵(6+10)可分散油悬浮剂
6％环吡氟草酮+10％草除灵+5％十二烷基苯磺酸钙+6％脂肪醇聚氧乙烯醚+5％蓖麻油氧乙烯醚+2.5％有机膨润土+2.5％气相法白炭黑+15％100#溶剂油+油酸甲酯补足
14. 13％环吡氟草酮·氟丙嘧草酯(12+1)可分散油悬浮剂
12％环吡氟草酮+1％氟丙嘧草酯+5％十二烷基苯磺酸钙+6％脂肪醇聚氧乙烯醚+5％蓖麻油氧乙烯醚+2.0％有机膨润土+2.0％气相法白炭黑+10％100#溶剂油+油酸甲酯补足
15. 11％环吡氟草酮·茚草酮(6+5)可分散油悬浮剂
6％环吡氟草酮+5％茚草酮+5％十二烷基苯磺酸钙+5％脂肪醇聚氧乙烯醚+6％蓖麻油氧乙烯醚+2.0％有机膨润土+2.0％气相法白炭黑+10％100#溶剂油+油酸甲酯补足
16. 11％环吡氟草酮·bixlozone(6+5)可分散油悬浮剂
6％环吡氟草酮+5％bixlozone+5％十二烷基苯磺酸钙+5％脂肪醇聚氧乙烯醚+6％蓖麻油氧乙烯醚+2.0％有机膨润土+2.0％气相法白炭黑+油酸甲酯补足
17. 36％环吡氟草酮·异噁草松(6+30)可分散油悬浮剂
6％环吡氟草酮+30％异噁草松+5％十二烷基苯磺酸钙+5％脂肪醇聚氧乙烯醚+6％蓖麻油氧乙烯醚+2.5％有机膨润土+2.5％气相法白炭黑+10％100#溶剂油+油酸甲酯补足
18. 26％环吡氟草酮·二氯喹啉草酮(6+20)可分散油悬浮剂
6％环吡氟草酮+20％二氯喹啉草酮+5％十二烷基苯磺酸钙+5％脂肪醇聚氧乙烯醚+6％蓖麻油氧乙烯醚+1.8％有机膨润土+1.5％气相法白炭黑+10％100#溶剂油+油酸甲酯补足
19. 7％环吡氟草酮·喹草酮(6+1)可分散油悬浮剂
6％环吡氟草酮+1％喹草酮+5％十二烷基苯磺酸钙+5％脂肪醇聚氧乙烯醚+6％蓖麻油氧乙烯醚+2.5％有机膨润土+2.5％气相法白炭黑+10％100#溶剂油+油酸甲酯补足
20. 10％环吡氟草酮·噁唑酰草胺(6+4)可分散油悬浮剂
6％环吡氟草酮+4％噁唑酰草胺+5％十二烷基苯磺酸钙+5％脂肪醇聚氧乙烯醚+6％蓖麻油氧乙烯醚+2.5％有机膨润土+2.5％气相法白炭黑+10％100#溶剂油+油酸甲酯补足
21. 8.5％环吡氟草酮·环苯草酮(6+2.5)可分散油悬浮剂
6％环吡氟草酮+2.5％环苯草酮+5％十二烷基苯磺酸钙+5％脂肪醇聚氧乙烯醚+6％蓖麻油氧乙烯醚+2.5％有机膨润土+2.5％气相法白炭黑+10％100#溶剂油+油酸甲酯补足
22. 8.5％环吡氟草酮·烯草酮(6+2.5)可分散油悬浮剂
6％环吡氟草酮+2.5％烯草酮+5％十二烷基苯磺酸钙+5％脂肪醇聚氧乙烯醚+6％蓖麻油氧乙烯醚+2.5％有机膨润土+2.5％气相法白炭黑+10％100#溶剂油+油酸甲酯补足
23. 31％环吡氟草酮·禾草灵(6+25)可分散油悬浮剂
6％环吡氟草酮+25％禾草灵+5％十二烷基苯磺酸钙+5％脂肪醇聚氧乙烯醚+6％蓖麻油氧乙烯醚+2.0％有机膨润土+2.0％气相法白炭黑+20％100#溶剂油+油酸甲酯补足
24. 11％环吡氟草酮·咪草烟(6+5)可分散油悬浮剂
6％环吡氟草酮+5％咪草烟+5％十二烷基苯磺酸钙+5％脂肪醇聚氧乙烯醚+6％蓖麻油氧乙烯醚+2.0％有机膨润土+2.0％气相法白炭黑+10％100#溶剂油+油酸甲酯补足
上述可分散油悬浮剂加工设备：混料釜、胶体磨、砂磨机、剪切机等。
上述可分散油悬浮剂加工过程：将所有物料投入混料釜中，搅拌混合后过胶体磨，之后进入砂磨机三级砂磨，最后在剪切机中剪切均匀，化验合格后，转移至储罐灌装。
B)药效试验
苗后茎叶喷雾处理:
1)试验条件
1.1)、供试靶标
猪殃殃、荠菜、稗草、日本看麦娘、菵草、千金子采自江苏兴化，野燕麦采自河南驻马店，雀麦、苘麻采自山东。上述杂草采用盆栽法培养，用180х140mm塑料营养钵，摆放于搪瓷盘中，内装从农田采回经风干过筛的表层土壤(4/5处)，土壤湿度初期均控制在20％， 挑选籽粒饱满均一的杂草种子，用25℃温水浸泡6小时，在28℃生化培养箱(黑暗)中催芽，将刚刚露白的杂草种子均匀摆放在土壤表面，根据种子粒径大小然后覆土0.5-1cm。
1.2)、培养条件
在可控日光温室内进行，温度20～30℃，自然光照，相对湿度57％～72％。土壤类型为壤土，有机质含量为1.63％，pH＝7.1，碱解氮84.3mg/kg，速效磷38.5mg/kg，速效钾82.1mg/kg。1.3)、仪器设备
3WP-2000型行走式喷雾塔，农业部南京农业机械研究所。GA10型万分之一电子天平(德国)；ZDR2000智能数据记录仪(杭州泽大仪器有限公司)；SPX型智能生化培养箱(宁波江南仪器厂)。
2)试验设计
2.1)、试剂
所需活性成分B由试剂公司购买，A为本公司生产。
原药均采用丙酮作溶剂，用含量0.1％乳化剂吐温-80水溶液稀释，现用现稀释。
2.2)、试验处理
2.2.1)、剂量设置
在确定A与活性成分B配比或含量时，应从两种药剂的作用特点及其毒力等衡量，还要考虑该配方的主要使用目的。本研究在前期预试的基础上，设A、B活性成分单用及混合用量分别见表格。以不含药剂、含相同溶剂及乳化剂的水作为空白对照。
2.2.2)、试验重复
每处理重复4次，每次每处理3盆，每盆播种杂草种子20粒，每处理共60株。
2.3)、处理方式
2.3.1)、处理时间和次数
试验共用药1次。待杂草1叶期，间苗，保持每盆内杂草15株，每处理保留45株，然后继续培养至2-3叶进行处理。
2.3.2)、使用器械和用药方法
将培养好的试材均匀摆放在面积0.5m 2的平台上，用3WP-2000型行走式喷雾塔茎叶喷雾，喷液量按30公斤/公顷计。喷雾压力0.3MPa。待全部药液喷完后，关闭气阀，30秒后，打开喷雾塔门，取出营养钵。然后打开气阀，喷清水50mL，清洗喷液管。
3)试验方法
采用盆栽法。杂草培养见1.1，参照《农药室内生物测定试验准则除草剂》进行。用药方法见2.3.2，采用茎叶处理法。处理后移入温室常规培养，试验期间始终保持1-2cm水层。 4)数据调查与统计分析
4.1)、调查方法
采用绝对数调查法，用刀片沿土壤表面切断存活杂草整株幼苗，用分析天平称量杂草鲜重。对于已经死亡的杂草，按鲜重为零计。
4.2)、调查时间和次数
处理后20天调查，共调查1次。
4.3)、数据统计分析
用Gowing法计算各处理混合组合的理论鲜重抑制率(E0＝X+Y-X*Y/100)，然后与实测抑制率(E)相比较，评价二者混用对杂草的联合作用类型，当E-E0值大于10％为增效作用、小于-10％为拮抗作用、在-10％～10％之间为加成作用。并根据实际防效和除草剂特点、配方的平衡性等因素确定最佳配比。式中X为活性成分A用量为P时的鲜重抑制率；Y为活性成分B用量为Q时的鲜重抑制率。
土壤封闭处理:
1)试验条件
1.1)、供试靶标
猪殃殃、荠菜、稗草、日本看麦娘、菵草、千金子采自江苏兴化，野燕麦采自河南驻马店，雀麦、苘麻采自山东。
1.2)、培养条件
在可控日光温室内进行，温度20～30℃，自然光照，相对湿度57％～72％。土壤类型为壤土，有机质含量为1.63％，pH＝7.1，碱解氮84.3mg/kg，速效磷38.5mg/kg，速效钾82.1mg/kg。试验土壤定量装至盆钵的3/4处，然后从盆钵底部浇灌，使土壤完全湿润至饱和状态。将预处理的供试杂草种子，均匀定量撒播表面，根据种子大小覆土0.5-2cm，播种后24小时备用。1.3)、仪器设备
GA10型万分之一电子天平(德国)；ZDR2000智能数据记录仪(杭州泽大仪器有限公司)；SPX型智能生化培养箱(宁波江南仪器厂)，移液器等。
2)试验设计
2.1)、试剂
所需活性成分B均为市售原药，A为本公司生产。
原药均采用丙酮作溶剂，用含量0.1％乳化剂T-80水溶液稀释，现用现稀释。
2.2)、试验处理
2.2.1)、剂量设置
在确定A与活性成分B各组分配比或含量时，应从两种药剂的作用特点及其毒力等衡量，还要考虑该配方的主要使用目的。本研究在前期预试的基础上，设A、B活性成分单用及混合用量分别见表格。以不含药剂、含相同溶剂及乳化剂的水作为空白对照。
2.2.2)、试验重复
每处理重复4次，每次每处理3盆，每盆播种杂草种子30粒。
3)试验方法
处理前浇灌，保持1-2cm水层。用移液器取定量药液，按照试验设计从低剂量到高剂量分别进行浇灌处理，每次处理4次重复；处理后移入温室常规培养，试验期间始终保持1-2cm水层。
4)数据调查与统计分析
与苗后茎叶喷雾处理相同，故不再赘述。
统计结果见下表1-24。
表1双唑草酮与草除灵混配对猪殃殃的实际防效及联合作用评价
Figure PCTCN2018105272-appb-000003
表2双唑草酮与氟丙嘧草酯混配对雀麦的实际防效及联合作用评价
Figure PCTCN2018105272-appb-000004
表3双唑草酮与茚草酮混配对稗草的实际防效及联合作用评价
Figure PCTCN2018105272-appb-000005
表4双唑草酮与bixlozone混配对荠菜的实际防效及联合作用评价(土壤处理)
Figure PCTCN2018105272-appb-000006
表5双唑草酮与异噁草松混配对野燕麦的实际防效及联合作用评价(土壤处理)
Figure PCTCN2018105272-appb-000007
表6双唑草酮与二氯喹啉草酮混配对千金子的实际防效及联合作用评价
Figure PCTCN2018105272-appb-000008
表7双唑草酮与喹草酮混配对苘麻的实际防效及联合作用评价(土壤处理)
Figure PCTCN2018105272-appb-000009
表8双唑草酮与噁唑酰草胺混配对千金子的实际防效及联合作用评价
Figure PCTCN2018105272-appb-000010
表9双唑草酮与环苯草酮混配对稗草的实际防效及联合作用评价
Figure PCTCN2018105272-appb-000011
表10双唑草酮与烯草酮混配对日本看麦娘的实际防效及联合作用评价
Figure PCTCN2018105272-appb-000012
表11双唑草酮与禾草灵混配对菵草的实际防效及联合作用评价
Figure PCTCN2018105272-appb-000013
表12双唑草酮与咪草烟配对苘麻的实际防效及联合作用评价(土壤处理)
Figure PCTCN2018105272-appb-000014
Figure PCTCN2018105272-appb-000015
表13环吡氟草酮与草除灵混配对猪殃殃的实际防效及联合作用评价
Figure PCTCN2018105272-appb-000016
表14环吡氟草酮与氟丙嘧草酯混配对雀麦的实际防效及联合作用评价
Figure PCTCN2018105272-appb-000017
表15环吡氟草酮与茚草酮混配对稗草的实际防效及联合作用评价
Figure PCTCN2018105272-appb-000018
Figure PCTCN2018105272-appb-000019
表16环吡氟草酮与bixlozone混配对荠菜的实际防效及联合作用评价(土壤处理)
Figure PCTCN2018105272-appb-000020
表17环吡氟草酮与异噁草松混配对野燕麦的实际防效及联合作用评价(土壤处理)
Figure PCTCN2018105272-appb-000021
表18环吡氟草酮与二氯喹啉草酮混配对千金子的实际防效及联合作用评价
Figure PCTCN2018105272-appb-000022
Figure PCTCN2018105272-appb-000023
表19环吡氟草酮与喹草酮混配对苘麻的实际防效及联合作用评价(土壤处理)
Figure PCTCN2018105272-appb-000024
表20环吡氟草酮与噁唑酰草胺混配对千金子的实际防效及联合作用评价
Figure PCTCN2018105272-appb-000025
表21环吡氟草酮与环苯草酮混配对稗草的实际防效及联合作用评价
Figure PCTCN2018105272-appb-000026
Figure PCTCN2018105272-appb-000027
表22环吡氟草酮与烯草酮混配对日本看麦娘的实际防效及联合作用评价
Figure PCTCN2018105272-appb-000028
表23环吡氟草酮与禾草灵混配对菵草的实际防效及联合作用评价
Figure PCTCN2018105272-appb-000029
表24环吡氟草酮与咪草烟配对苘麻的实际防效及联合作用评价(土壤处理)
Figure PCTCN2018105272-appb-000030
Figure PCTCN2018105272-appb-000031
C)大田示范
利用实施例1)-24)制得的除草剂组合物进行田间杂草效果试验。
2017年在河南驻马店试验点进行示范性推广试验。田间发生的杂草主要有：荠菜、牛繁缕、猪殃殃、看麦娘等等。
试验方法:
土壤处理:于杂草发芽前，手动喷雾器，兑水量45公斤/667m 2，采用土壤表面均匀喷雾。
茎叶处理:待杂草处于2-3叶期，手动喷雾器，兑水量30公斤/667m 2，采用茎叶喷雾均匀喷雾。
具体试验药剂及剂量详见表25，小区面积50平方米，每处理重复4次。施药后45天调查防除效果见表25。
Figure PCTCN2018105272-appb-000032
表25所述复配组合物的大田示范效果情况
实施例 剂型 用量(g a.i./ha) 鲜重防效(％)
实施例1 OD 180 93.4
实施例2 OD 37.5 96.5
实施例3 OD 105 95.4
实施例4 OD 105 97.3
实施例5 OD 480 94.7
实施例6 OD 330 96.9
实施例7 OD 45 95.9
实施例8 OD 90 94.6
实施例9 OD 67.5 93.1
实施例10 OD 67.5 95.9
实施例11 OD 405 93.9
实施例12 OD 105 93.7
实施例13 OD 240 95.2
实施例14 OD 97.5 96.1
实施例15 OD 165 97.4
实施例16 OD 165 94.8
实施例17 OD 540 98.3
实施例18 OD 390 97.2
实施例19 OD 105 96.2
实施例20 OD 150 96.6
实施例21 OD 127.5 94.5
实施例22 OD 127.5 98.1
实施例23 OD 465 94.9
实施例24 OD 165 98.1
10％双唑草酮OD   30 34.5
12％环吡氟草酮OD   135 57.3
10％草除灵OD   150 25.3
0.5％氟丙嘧草酯OD   7.5 33.1
5％茚草酮OD   75 37.2
5％bixlozoneOD   75 41.4
30％异噁草松OD   450 37.5
20％二氯喹啉草酮OD   300 26.4
1％喹草酮OD   15 24.2
4％噁唑酰草胺OD   60 31.5
2.5％环苯草酮OD   37.5 22.6
2.5％烯草酮OD   37.5 24.7
25％禾草灵OD   375 25.6
5％咪草烟OD   75 26.1
经过大量试验和探索，本发明意外地发现，所述组合物用于防除猪殃殃、荠菜、稗草、日本看麦娘、菵草、千金子、野燕麦、雀麦、苘麻等杂草，具有令人惊讶的、意想不到的增效作用，这种增效作用在低剂量下表现更为显著，可降低用药量，降低对环境的污染，且合理复配降低了农用成本，对ALS、ACCase抑制剂抗性杂草高效，具有很好的应用前景。同时经过测试在小麦田、玉米田、水稻田、花生、甘蔗、高粱、谷子、马铃薯、油菜、大豆、棉花、蔬菜、早熟禾、高羊茅、结缕草等草坪和作物显示良好的选择性和优异的增效作用，可以开发成广泛市场价值的除草剂混剂。

Claims (10)

  1. 一种包含HPPD抑制剂类除草剂的二元除草组合物，其特征在于，包括除草有效量的活性成分A和活性成分B，其中，
    活性成分A选自以下HPPD抑制剂类除草剂化合物中的一种或多种：双唑草酮、环吡氟草酮和/或其盐/酯等衍生物；
    活性成分B选自以下化合物中的一种或多种：草除灵、氟丙嘧草酯、茚草酮、bixlozone、异噁草松、二氯喹啉草酮、喹草酮、噁唑酰草胺、环苯草酮、烯草酮、禾草灵、咪草烟和/或其盐/酯等衍生物。
  2. 根据权利要求1所述的一种包含HPPD抑制剂类除草剂的二元除草组合物，其特征在于，A、B的重量比为1～200:200～1和1～150:150～1；优选为1～120:120～1和1～100:100～1；更优选为1～80:80～1和1～50:50～1；进一步优选为1～30:30～1和1～10:10～1。
  3. 根据权利要求1或2所述的一种包含HPPD抑制剂类除草剂的二元除草组合物，其特征在于，所述除草组合物中A、B的质量百分含量占总量的1-95％，优选10-80％。
  4. 根据权利要求1至3任意一项所述的一种包含HPPD抑制剂类除草剂的二元除草组合物，其特征在于，所述除草组合物中还包括常规助剂。
  5. 根据权利要求4所述的一种包含HPPD抑制剂类除草剂的二元除草组合物，其特征在于，所述常规助剂包括载体、表面活性剂。
  6. 根据权利要求1至5任意一项所述的一种包含HPPD抑制剂类除草剂的二元除草组合物，其特征在于，所述除草组合物进一步包括至少一种安全剂。
  7. 根据权利要求1至6任意一项所述的一种包含HPPD抑制剂类除草剂的二元除草组合物，其特征在于，所述除草组合物的具体制剂为可分散油悬浮剂、水悬浮剂、悬乳剂、可湿性粉剂、乳油、水分散粒剂、水乳剂或微乳剂。
  8. 如权利要求1至7任意一项所述包含HPPD抑制剂类除草剂的二元除草组合物在防治作物中杂草上的应用。
  9. 一种防治不想要的植物生长的方法，其包括将权利要求1至7任意一项所述包含HPPD抑制剂类除草剂的二元除草组合物施用于植物、植物部位、植物种子或植物生长的区域。
  10. 根据权利要求9所述的方法，其特征在于，用于选择性防治作物中的杂草。
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