WO2020006845A1 - Procédé d'évaluation d'une réserve de santé, et dispositif et application de celui-ci - Google Patents

Procédé d'évaluation d'une réserve de santé, et dispositif et application de celui-ci Download PDF

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WO2020006845A1
WO2020006845A1 PCT/CN2018/102289 CN2018102289W WO2020006845A1 WO 2020006845 A1 WO2020006845 A1 WO 2020006845A1 CN 2018102289 W CN2018102289 W CN 2018102289W WO 2020006845 A1 WO2020006845 A1 WO 2020006845A1
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health
reserve
value
data
exercise
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PCT/CN2018/102289
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Chinese (zh)
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曹阳
石波
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深圳迪美泰数字医学技术有限公司
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment

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  • the invention relates to the field of health state assessment, and specifically relates to a health reserve assessment method, device and application thereof.
  • Quantitative health management depends on the quantitative assessment of health reserves, and its applications are extremely widespread. For healthy people, they can maintain health, warn of accidents, and prompt consumption metabolic problems; for sub-healthy people, they can restore health, adjust lifestyle, increase life expectancy, and prompt consumption metabolic problems; for chronically ill people, they can improve health indicators and reduce Or avoid clinical treatment, suggesting the risk of cardiovascular and cerebrovascular accidents, and suggesting wasting metabolic problems; for heart disease patients, it is possible to evaluate the effectiveness of rehabilitation, establish a rehabilitation program, monitor changes in the condition, and reduce the risk of accidents; for cancer patients, it is possible to suggest early consumption Metabolic problems, assist in cancer grading, assist in formulating treatment plans, perform prognostic survival, evaluate rehabilitation effects, guide rehabilitation programs, and monitor the possibility of relapses.
  • the current evaluation of the training dose is mainly based on the athlete's performance and complaints, and a rough estimate of the average heart rate + exercise time. It is impossible to accurately quantify excessive exercise, excessive fatigue, lack of sleep, poor eating, and disease status. Adjustment. For professional athletes, traumatic blood biochemical tests, such as blood lactate levels, serum creatine kinase, and blood urea, are harmful to the human body, not only the risk of infection, but also not suitable for repeated measurements.
  • an object of the present invention is to provide a technology and means that can perform non-invasive, dynamic, and quantitative measurement analysis and assessment of health reserves, which can be used for Its dynamic changes provide quantitative descriptions of health reserve assessment methods, devices, and applications.
  • the present invention provides a health reserve assessment method, which includes the following steps:
  • the step of performing composite variable analysis of the health reserve value of the point process signal data specifically includes performing composite variable analysis of the point process signal data in a time domain, a frequency domain, and a non-linear domain.
  • the method further includes calculating a change degree of the health reserve according to a statistical distribution of the health reserve value obtained through measurement and calculation for multiple periods, so as to evaluate the activity of the individual's health status.
  • the method further includes transmitting the personal health reserve value to a health management expert system, and the health management expert system analyzes, evaluates, and manages the health of the personal health reserve value, the activity, and the accumulated data of the independent balance value through the Internet.
  • the invention also provides a health reserve assessment device, which includes:
  • a data acquisition unit configured to perform steps to obtain a human pulse signal / heart sound signal / cardiac signal
  • a data conversion unit configured to convert the collected signals into point process signal data
  • a data analysis unit configured to perform the step of performing a composite variable analysis of the health reserve value of the point process signal data, and forming a monotonic function reflecting the state of the health reserve;
  • a health state evaluation unit configured to perform a qualitative and quantitative determination of human health according to a statistical distribution parameter of a population's health reserve value
  • the output end of the data acquisition unit is connected to the input end of the data conversion unit; the output end of the data conversion unit is connected to the input end of the data analysis unit; the output end of the data analysis unit is connected to all The input terminal of the health evaluation unit is described.
  • the device further includes an instruction output unit, and an input terminal of the instruction output unit is connected to an output terminal of the health state assessment unit, and is configured to output sound, color, text, or An image to guide the user to follow the content in the indication output unit to change the corresponding behavior.
  • the present invention also provides an application of a health reserve assessment device in the assessment of health improvement, health deterioration, disease risk, and prognosis of health processes, which specifically include:
  • a health reserve assessment device in exercise volume assessment includes:
  • the application of a health reserve assessment device in health status assessment includes:
  • the health reserve assessment method, device and application provided by the present invention obtain a monotonic function reflecting the state of the health reserve by acquiring the human pulse signal / heart sound signal / ECG signal, and performing data processing and analysis.
  • the statistical distribution parameters of the health reserve value can be used for qualitative and quantitative determination of human health. It overcomes the shortcomings in the prior art of assessing human health reserve values and variability values by requiring invasive methods such as corresponding injury or surgery on the human body to obtain human body related parameter information, and achieves users' health under the condition that daily life is not disturbed The effect of the reserve value and its dynamic changes, which in turn guide and manage user health.
  • the heartbeat signal can be obtained through non-invasive methods, and individuals can be easily collected through wearable devices under the condition that daily life is not disturbed. It can be continuously monitored, and the long-term dynamic change trend can reflect small Change, through the big data analysis of the population, can achieve accurate guidance of personal health, and can early warning of many disease risks.
  • the health reserve assessment method of the present invention is simple and reliable, easy to implement, can be repeatedly measured and evaluated, and can be widely used for health assessment, health screening, health guidance, athlete screening and training, sports rehabilitation guidance, disease early warning, Many areas such as treatment dose and course adjustment, early detection of relapse and so on.
  • FIG. 1 is a control flowchart of health reserve assessment according to an embodiment of the present invention
  • FIG. 2 is a real-time heart rate trend graph in one embodiment of the present invention
  • FIG. 3 is a schematic diagram of an analysis result of an individual based on different times of the day according to an embodiment of the present invention
  • FIG. 4 is a schematic diagram of a distribution of CRI with age according to an embodiment of the present invention.
  • FIG. 5 is a schematic diagram of CRI numerical results based on different ages according to an embodiment of the present invention.
  • FIG. 6 is a schematic diagram of a health reserve assessment system according to an embodiment of the present invention.
  • FIG. 7 is a schematic diagram of a system according to an embodiment of the present invention.
  • FIG. 8 is a schematic diagram of a system according to another embodiment of the present invention.
  • Health reserve function At this time, at the level of health management, dietary prescriptions, exercise prescriptions, and sleep prescriptions should be adjusted in a timely manner. When the health reserve is increased, the exercise dose and dietary mix should be increased accordingly to further consolidate the rehabilitation effect. At the level of clinical diagnosis and treatment, measures such as pathological decompensation, infection prevention, wound healing, termination of consumption, detoxification and detoxification should be promptly corrected.
  • the present invention provides a health reserve assessment method.
  • the method includes: the system converts the received human pulse signal or heart sound signal or electrocardiogram signal into point process signal data; the heart rate data is a typical point process The data is derived from the QRS peak extraction of the ECG waveform. The signals such as the ECG to be collected will obtain a series of discrete point sets based on the time distribution.
  • the system will analyze the compound variables of the health reserve value of the above-mentioned point process signal data to form a Monotonic function reflecting the state of health reserve; the system makes qualitative and quantitative judgments of human health based on the statistical distribution parameters of the population's health reserve value.
  • the healthy reserve is the heart reserve, which is defined as the ability of the cardiac output CO to increase from rest to a maximum. CO is directly proportional to HR and it is controlled by the autonomic nerve. Therefore, the degree of heart rate variability also reflects CR and can be a candidate for quantitative estimation of CR. Multiple heart rate variability HRV parameters are affected by autonomic control, but the functional relationship and degree are different, and different interference factors have different degrees of influence on the parameters. Some of these parameters are closely related to sympathetic nerve activity and others are closely related to vagal nerve activity. Multivariate integrals are used to estimate the sympathetic and vagus nerve activities, respectively, to assess the state of autonomic function and accurately reflect the capacity of the healthy reserve (heart reserve).
  • the ECG data acquisition uses, for example, a DiCare-mlCC type miniature electrocardiograph (Dimetek Digital Medical Technology., Ltd., Shenzhen, China).
  • the signal bandwidth is set to 0.6-40 Hz
  • the sampling rate is 200 sps
  • the sampling accuracy is 24 bits.
  • the ECG recording time for age distribution analysis is 3 minutes, which usually contains about 200 heartbeats. Record the status as quiet sitting. Part of the recording time is up to 15 minutes.
  • the user sits on the exercise bike and continuously records the ECG waveform, covering the whole process of pre-, post-, and post-exercise. Another part records different periods and different activity states from the same individual, such as resting state and exercise state, as well as different periods of each day, and is not limited to activities.
  • R-wave automatic extraction algorithms mainly include: threshold method, template matching method, wavelet transform method, neural network method, mathematical morphology algorithm, etc.
  • an adaptive QRS template construction algorithm based on Gaussian approximation is preferably used, and the R wave extraction is completed based on the template.
  • the subject's heart rate must be sinus heart rate. When subjects experience occasional missed or premature beats, singularities appear in the RRI time series. Therefore, these singularities must be eliminated before analysis to reduce the error impact on the analysis results. For the case of missed beat, you need to divide the abnormal RRI value by 2 and insert the same value; for the case of premature beat, you need to add the two abnormal RRI values as one value, and remove the original Outliers.
  • Heart rate data is typical point process data, which is derived from the QRS peak extraction of ECG waveforms.
  • the RR interval is used for HRV analysis of heart rate variability.
  • the heart rate variability HRV has multiple analysis parameters, including RR, HR, SDNN, ASDNN, RMSD, SD50, TP, LF, HF, and so on.
  • HRV frequency domain analysis LF reflects sympathetic control tension and HF reflects vagal control tension.
  • LF reflects sympathetic control tension
  • HF reflects vagal control tension.
  • Transient transient changes such as heart rate acceleration or deceleration tend to change, and the analysis effect becomes worse. At this time, there may be no stable periodic changes in sympathetic and vagal activities.
  • Another method for assessing the slow and rapid changes in heart rate is to analyze the RR interval and its non-linear stroke RR interval standard deviation SD1 and diagonal RR interval standard deviation SD2 by a time domain method. Although this analysis is not sensitive to the non-steady state, it is greatly affected by the occasional RR interval beating.
  • the frequency domain analysis parameters and time domain analysis parameters are used to calculate the slow heart rate change and the fast heart rate change at the same time, which can reduce the error, improve the stability of the analysis result, and reflect the state of plant nerve activity more objectively.
  • HRV time-domain parameters including all normal sinus RRI Mean Mean RR, all normal sinus RRI standard deviation SDNN, and adjacent RRI. Difference in root mean square RMSSD and so on.
  • the SDRR calculation formula is as follows:
  • N is the total number of samples.
  • frequency-domain analysis is power spectral density (PSD) analysis.
  • PSD power spectral density
  • LF norm low frequency power
  • HFnorm standardized HF power
  • Poincaré scatter plot is a two-dimensional coordinate system with the horizontal axis being x and the vertical axis being y. The value on the axis represents the interval, and the value on the axis represents the interval immediately following it.
  • Most researchers use the ellipse fitting method to analyze the Poincaré scatter plot and the SD1 and SD2 standard deviations of the RR interval per stroke. Its formula is:
  • N is the total number of samples.
  • the parameters used to calculate the health reserve index CRI include: total power TP (endpoint symbol P), low frequency power LF (endpoint symbol F), high frequency power HF (endpoint symbol M), and RR interval orthogonal standard deviation SD1 (Endpoint symbol V), RR interval standard deviation SDNN (endpoint symbol H), RR interval backcross standard deviation SD2 (endpoint symbol S), sympathetic nerve activity value SA and vagus nerve activity value VA; among them,
  • the health reserve index CRI is the vector sum of SA and VA:
  • the method further includes calculating a change degree of the health reserve according to the statistical distribution of the health reserve value obtained through measurement and calculation for multiple periods, so as to evaluate the activity of the individual's health status.
  • the daily activities of individuals significantly affect the CRI value of the heart reserve, and the analysis results recorded at different times will vary greatly.
  • FIG. 3 it can be seen from the figure that the daytime activities (9: 00-11: 30) compared with night sleep (11: 00-7: 00) and noon break (11: 45-14: 00), CR Significantly larger, but also subject to change.
  • daytime activities its value is small and the variability is also small.
  • the individual heart reserve variability function is the standard deviation of the individual heart reserve value, and this example reaches 10.19.
  • CRI showed a gradual and gradually changing trend, which is consistent with previous studies.
  • the average CRI value is calculated and displayed as the age.
  • the ECRI for the specified age can be calculated.
  • the individual's own heart reserve value can also change at different periods.
  • the standard deviation of its variation reaches 10.19 ( Figure 3). But compared to the expected SD value of 17.99 of the same age, it is significantly smaller. This result suggests that the changes in CRI caused by one's daily activities tend to be smaller than the differences in resting CRI between individuals.
  • ECRI is the expected normal value of CRI at the specified age, and the degree of variation determines the range of statistical normal values. Referring to Figure 5, measured by the expected standard deviation ESD, the 95% interval is about 2ESD. Above ECRI to ECRI + 2ESD is a supernormal range, and below ECRI to ECRI-2ESD is a subnormal range. Below ECRI-2ESD is a weak CRI range, and beyond ECRI + 2ESD is an unstable range.
  • This solution also includes transmitting the personal health reserve value to a health management expert system, and the health management expert system analyzes, evaluates, and manages the health of the cumulative data of the personal health reserve value, activity, and autonomous balance value via the Internet.
  • the data records are transmitted to the remote data analysis center via the Internet.
  • the analysis center provides the results of the health reserve assessment to monitor the rehabilitation of the patient's health reserve capacity to the maximum extent, while making the operation of the patients the simplest and transparent.
  • Patients need to rent / purchase life reserve analysis terminal equipment, record daily at a specified time period, and automatically upload data.
  • Internet is required in the home environment.
  • the remote data analysis center analyzes the data and gives an evaluation report, and forwards it to a health management expert. This method is characterized by sufficient data, accurate assessment, and accurate and effective health guidance.
  • the health reserve value, activity level, and autonomous balance value calculated according to the data from the heart beat signal are compared with the normal range of the crowd to determine the hyperactivity of yin and yang deficiency, the degree of physical fatigue, the speed of recovery after exercise, the judgment of rehabilitation effects, and cardiac accidents. Risk, cancer occurrence probability, cancer tissue staging, cancer survival, cancer recurrence probability.
  • the system also calculates the degree of change in the health reserve according to the statistical distribution of the health reserve value obtained through measurement and calculation over multiple periods, so as to evaluate the activity of the individual's health status. Activity was lower than one standard deviation of the average of the statistical distribution of the population, and was determined to be abnormal.
  • the change trend of the individual's health and life reserve, and the health state at the expected time are judged.
  • the trend of a gradual increase in health reserve value and / or a gradual increase in activity is judged to be an improvement in health; the trend of a gradual decrease in health reserve value and / or a gradual decrease in activity is judged to be a deterioration in health.
  • cancer screening such as a method for cancer screening, cancer treatment assessment and cancer prognosis assessment, and cancer recurrence risk assessment, which includes the health reserve value and activity calculated from the heart beat signal data, and The data of the autonomous balance value are accumulated and calculated according to the recorded time to obtain the change trend and time change rate of the health reserve value and the time change rate of its activity, and perform cancer patient screening according to the change trend and time change rate, Cancer treatment dose control, cancer development degree and prognosis evaluation, cancer rehabilitation effect evaluation, cancer recurrence risk evaluation.
  • the occurrence of cancer can be detected and warned early through the trend of life reserve value, treatment and rehabilitation can be effectively guided by the change of life reserve, and cancer recurrence can be detected early by continuously monitoring the trend of life reserve.
  • Illness can significantly reduce life reserve, such as acute infection, sudden trauma, wasting disease, drug control or poisoning.
  • life reserve value will drop sharply within a few days.
  • Chronic metabolic diseases can also significantly reduce life reserve values, but the process is long and slow to change, reaching up to several years.
  • Cancers with a high degree of malignancy usually have a steady decline in their life reserve value to a very low level within the range of 1-3 months, and also reflect the continuous progress of their clinical stage.
  • the dynamic change of life reserve value is not a highly specific and sensitive cancer screening method, the evaluation process is simple and non-invasive, and can be used repeatedly for a long time. It is not affected by missed diagnosis of histological examination and is not affected by imaging confirmation. Leukoplasia or nodules. In particular, it can be used as a valuable auxiliary test before the diagnosis of pathology is confirmed. If the test result is negative and the imaging indicates a occupying lesion, the result of the imaging test should be highly suspected; if the test is positive, the life reserve is The value can be used as an estimate of the non-traumatic invasion degree of cancer staging, and continuous monitoring should be performed at least as a diagnostic reference before treatment to assist in the development of a treatment plan.
  • the patient's life reserve value continues to decrease every day, and the decline rate is faster than the cancer development rate.
  • the analysis of the dynamic change trend of the patient's life reserve value can predict the patient's expected end date, and the treatment dose and treatment period must consider the patient's ability to bear.
  • the expected end date can be used as an important reference to control the treatment dose and treatment period at Patient life tolerance. Therefore, during the course of chemoradiotherapy for cancer patients, the dynamic changes and trends of their life reserve values should be continuously monitored. This work is usually performed in medical institutions.
  • Cancer rehabilitation must be quantitatively and effectively managed from many aspects such as diet, health care, sports, psychology, etc., in order to help cancer patients overcome difficulties and restore health.
  • the size of the life reserve value can directly reflect the patient's recent survival probability, which can be determined based on this:
  • dietary prescriptions, exercise prescriptions, psychological prescriptions, and health drug prescriptions should be adjusted dynamically, which should be based on objectively measured changes in life reserve values. If the life reserve value gradually increases, it means that the rehabilitation management plan is effective, and the dose should be maintained and adjusted accordingly. If the life reserve value does not change, it means that the rehabilitation management plan is ineffective or has not yet produced effects. Care should be taken to consider whether the rehabilitation prescription is correct. The value decreases continuously, suggesting that the rehabilitation management plan may be wrong, or the cancer cells have begun to proliferate, which needs to be immediately verified and processed.
  • cancer survivors generally show signs of over-aging, which is essentially due to the fact that the healthy age is far greater than the biological age.
  • age-reverse growth which is as follows: objectively, the life reserve value recovers to a healthy range or even exceeds the age of peers, subjectively is energetic, thinks quickly and acts quickly, and externally looks at the biological age. Therefore, long-term continuous monitoring of the dynamic changes of life reserve and guidance of rehabilitation management and health management will effectively help to establish accurate rehabilitation prescriptions, track rehabilitation effects, correct rehabilitation deviations, and reflect the value of rehabilitation.
  • a method for assessing insufficient or excessive exercise includes: a health reserve assessment device that separately records an individual's health reserve value before and after exercise, and measures the health reserve value after exercise to return to before exercise Time required for level. If the recovery time is too short, the amount of exercise is insufficient; if the recovery time is too long, the exercise training is excessive.
  • heart rate In sports rehabilitation and training, the most commonly used measurement parameter is heart rate.
  • heart rate can be used as a reference indicator for exercise dose adjustment, in fact, because the information reflected by heart rate is too simple, general guidance on exercise dose is not a personalized exercise prescription. Many people exercise, or the training dose is insufficient, or feel Overworked and overworked. Therefore, heart rate is not an accurate exercise dose assessment indicator. Analysis of research data shows that exercise reduces the health reserve value and gradually recovers after stopping exercise, but some people's health reserve cannot be restored quickly, although the heart rate has been restored. It is generally believed that 15-30 minutes after exercise to return to the state before exercise is a suitable exercise dose for the general population, from the perspective of health reserve value, it appears to return to the level before exercise.
  • the health reserve value cannot be recovered within 2 hours after exercise, it indicates that the exercise dose is too large. Many factors, such as diet and sleep, reduce health reserves, affect tolerance to exercise doses, and speed of recovery. On the other hand, if the recovery is too fast, it indicates that the exercise dose is too small to achieve the best effect of exercise rehabilitation. As shown in Table 2 and Table 3.
  • the recovery time of the health reserve value should be taken as an important reference index for adjusting the exercise dose.
  • a method for evaluating a physical health state includes: calculating the health reserve value and activity obtained for multiple periods according to measurement calculations, and the population according to the health reserve
  • the biological age distribution characteristics of the value and the activity degree describe the corresponding healthy age of the individual's health status, and express the health status by the difference between the healthy age and the biological age.
  • the population statistics of health reserve value and active population the health status of individuals is described correspondingly, and the difference between healthy age and biological age is used to express their health status: healthy people show that their healthy age reverses growth and is smaller than biological Age; non-healthy people show that their healthy age is older than biological age; end-of-life people show that their healthy age is close to the limit of life.
  • This technology makes individuals more directional and motivated for health goals, easier to operate, and can understand their healthy age situation at any time.
  • the present invention further provides a health reserve assessment device, which includes:
  • a data acquisition unit configured to perform steps to obtain a human pulse signal / heart sound signal / cardiac signal
  • a data conversion unit configured to execute the step system to convert the received human pulse signal or heart sound signal or electrocardiogram signal into point process signal data
  • a data analysis unit configured to perform step-by-step systematic analysis of the compound variables of the health reserve value of the point process signal data, and form a monotonic function reflecting the state of the health reserve;
  • the health state evaluation unit is configured to perform a step system to make a qualitative and quantitative determination of human health according to a statistical distribution parameter of a population's health reserve value.
  • the device further includes an instruction output unit, and an input terminal of the instruction output unit is connected to an output terminal of the health state assessment unit, and is configured to output sound, color, text, or image when collecting a heart beat signal to guide a user to follow
  • the instructions indicate a corresponding behavior change in the content of the output unit.
  • the data acquisition unit may be a heart beat signal acquisition unit, such as a heart rate monitor or a miniature electrocardiogram / heart sound monitoring unit or a miniature pulse recording unit.
  • this solution also provides a health reserve detection system.
  • the evaluation is performed so that users can know their current health status anytime, anywhere; further, based on the above evaluation results, the system provided by this solution can also give Corresponding guidance helps users to restore health reserves and improves user experience.
  • the present invention also provides a health reserve detection system, including: a heart beat signal acquisition unit, a data conversion unit, a data processing unit (data analysis unit), and a health state assessment unit; the heart beat signal collection The output of the unit is connected to the input of the data conversion unit; the output of the data conversion unit is connected to the input of the data processing unit; the output of the data processing unit is connected to the input of the health evaluation unit connection.
  • the data processing unit may be a component having a processing function such as a microprocessor or a single-chip microcomputer.
  • the heart beat signal acquisition unit is used to collect a human heart beat signal.
  • the heart beat signal acquisition unit is a heart rate monitor or a miniature electrocardiogram / heart sound.
  • Monitoring unit or miniature pulse recording unit used to collect human heart rate / ECG / heart sound signal or pulse beat signal, etc .
  • data conversion unit is used to convert human heart beat signal collected by heart beat signal acquisition unit into point process signal data, data
  • the processing unit analyzes the compound variables of the health reserve value by the point process signal data and forms a monotonic function reflecting the health reserve status; then transmits the processed health reserve data to the health status assessment unit, and the health status assessment unit performs the above data Evaluation, such as judging the changes in personal health and life reserve and their expected health status over time, it performs quantitative health status analysis and evaluation of heart beat signals.
  • the health state evaluation unit can perform calculation and evaluation through an existing health reserve (heart reserve) algorithm.
  • the system further includes a result display unit, and an output end of the health status evaluation unit is connected to an input end of the result display unit for displaying the evaluation result so that the user can intuitively view it. It shows the current state of health and its trends, and provides advice and guidance on individual lifestyles and early warning of potential disease risks.
  • the system further includes a communication module, which is connected to the data processing unit and is used to implement remote data exchange.
  • the system further includes: a remote health service unit and a health management expert system, the remote health service unit transmits personal health reserve data to the health management expert system through a communication module, and the health management expert system
  • the health reserve data is analyzed and evaluated, and health guidance, health warning, health guidance, disease prompts, diagnosis and treatment recommendations, and health management recommendations are given.
  • the personal health reserve value output by the data processing unit is transmitted to the remote health service unit and the health management expert system through the communication module, and the health management expert system can accumulate the personal health reserve value and the active data of the active balance value through the Internet. Etc. for analysis and evaluation and health management.
  • the data records are transmitted to the health management expert system through the Internet.
  • the health management expert system provides the results of the health reserve assessment to monitor the rehabilitation status of the patient's health reserve capacity to the greatest extent, while making the operation of the patients the simplest and transparent.
  • Patients are recorded daily at a specified time period, and the data is automatically uploaded.
  • the data is further processed and analyzed by the health management expert system and forwarded to the health management expert.
  • the system further includes a sound output unit, and an input end of the sound output unit is connected to an output end of the data processing unit for outputting sound to guide a user to adjust breathing according to the sound rhythm. It can be used to guide the subject's breathing, and the time and frequency of guiding the inhalation and its combination, the time and frequency of guiding the exhalation and its combination, the cycle time of the guiding breath, the sound rhythm and the sound effector can be adjusted separately.
  • the sound output unit plays the sound content that guides breathing, and guides the subject to adjust the rate and rhythm of inspiration and expiration.
  • the sound output unit may be a speaker, an earphone, or a speaker, etc., which can output sound, and the specific form of the sound output unit is not limited herein.
  • the system further includes a graphic display unit, and an input end of the graphic display unit is connected to an output end of the data processing unit for outputting an image to guide a user to follow the information displayed by the image to improve the corresponding health status.
  • the graphic display unit can dynamically display the animation content to guide the subject to adjust the rate and rhythm of inspiration and expiration.
  • the result display unit, sound output unit, and graphic display unit of this embodiment may be integrated as an instruction output unit for outputting sound, color, text, or image when collecting a heart beat signal to guide the user to follow the instruction output
  • the content in the unit changes accordingly.
  • This solution also provides a wearable device, which includes the health reserve assessment system / device; wherein the wearable device may be a smart bracelet, a smart watch, a smart necklace, or the like. All of them can realize the portable and convenient human health reserve value, real-time monitoring and management of human body related information.
  • the health reserve evaluation system includes a heart beat signal acquisition unit, a point process signal data analysis unit, a health reserve value calculation unit, and a health state evaluation unit.
  • the output end of the heart beat signal acquisition unit and The input of the point process signal data analysis unit is connected, the output of the point process signal data analysis unit is connected to the input of the health reserve value calculation unit, and the output of the health reserve value calculation unit is connected to the input of the health state evaluation unit.
  • the point process signal data analysis unit and the health reserve value calculation unit of this embodiment may be integrated into one unit. Specifically, it may be a microprocessor, a single-chip microcomputer, or other data processing unit.
  • the heart beat signal acquisition unit converts pulse beat signals or heart sound signals or ECG signals into point process signal data, and transmits the converted data to the point process data analysis unit to perform composite variable analysis of the health reserve value;
  • the point process data analysis unit performs time, frequency, and non-linear composite variable analysis on the point process signal data, and uses the analysis result for numerical analysis of health reserve;
  • the health reserve value calculation unit performs multivariate parameter analysis on two or more time, frequency, and nonlinear domain variable values to form a monotonic value that reflects the state of health reserve, and reflects the relative balance of sympathetic and vagus nerve activity. Negative monotonically varying autonomous balance values;
  • the health status evaluation unit performs normal or abnormal qualitative and quantitative judgments based on the statistical distribution parameters of the population's health reserve value. If the health reserve value is set to be lower than one standard deviation of the average value of the statistical distribution of the population, it is determined that the health status is abnormal.
  • It also includes a result display unit to display the results of the assessment and provide advice and guidance on individual lifestyles and early warning of potential disease risks.
  • an instruction output unit is further provided.
  • the instruction output unit is used to guide the breathing of the subject, and the time for guiding the inhalation, the time for guiding the exhalation, and the cycle time for guiding the breathing are adjustable respectively.
  • the output unit is instructed to dynamically display sound or animation content to guide the subject to adjust the rate and rhythm of inspiration and expiration.
  • the system also includes a sound output unit as described.
  • the sound output unit is used to guide the subject's breathing, and the time and frequency of guiding the inhalation and its combination, the time and frequency of guiding the exhalation and its combination, the cycle time of the guiding breath, the sound rhythm and the sound effector are adjustable respectively. While recording the heartbeat signal, the sound output unit plays the sound content that guides breathing, and guides the subject to adjust the rate and rhythm of inspiration and expiration.
  • a remote health service unit and a health management expert system are also provided.
  • the remote health service unit transmits personal health reserve data to the health management expert system through a communication module, and the health management expert system
  • the health reserve data is analyzed and evaluated, and health guidance, health warning, health guidance, disease prompts, diagnosis and treatment recommendations, and health management recommendations are given.
  • This embodiment overcomes the shortcomings of the prior art that must be performed in a specialized hospital or institution for traumatic surgery, and achieves the effect that users can understand their current health status anytime, anywhere, and improves the user experience. Convenient and safe, and beneficial to the physical and mental health of users.
  • a health reserve assessment device for assessing a health state and a disease state includes:
  • Heart beat data acquisition unit which converts pulse beat signals or heart sound signals or ECG signals into point process signal data, and transmits the converted data to the point process data analysis unit to perform composite variable analysis of the health reserve value;
  • a composite variable data analysis unit that performs composite analysis of the point process signal data in a time domain, a frequency domain, and a non-linear domain, and uses the analysis result for the health reserve numerical analysis
  • the health reserve value calculation unit performs multivariate parameter analysis on two or more of the time domain, frequency domain, and non-linear domain variable values to form a monotonic value that reflects the state of health reserve, and reflects the sympathetic and vagus nerves. Autonomous equilibrium value of monotonic change of positive and negative relative equilibrium activity;
  • the health status evaluation unit performs normal or abnormal qualitative and quantitative judgments based on the statistical distribution parameters of the population's health reserve value. Health reserve values below one standard deviation of the average of the population's statistical distribution were judged as abnormal health status.
  • This program can quantitatively evaluate the health status and dynamic changes of healthy populations, sub-healthy populations, chronically ill populations, heart disease populations, and cancer populations, and correctly guide and quantitatively evaluate health management, health maintenance, disease early warning, and disease rehabilitation Etc. have great application value.
  • It uses a completely non-invasive data analysis method to obtain a comprehensive quantitative assessment of human health, can continuously acquire data in daily life, and can repeatedly and non-invasively monitor personal health status outside the laboratory of a medical institution, while also completely avoiding invasion Potential risks and operational complexity associated with formal inspections. It objectively reflects the changes in the health reserve and health activity of the subjects at different periods, and is used to guide healthy lifestyles, such as exercise volume and sleep time.
  • the personal health reserve big data obtained by the present invention can also be remotely transmitted to a health management expert system via the Internet, which provides individuals with professional health status assessment and health management guidance, and can be compared with the statistical distribution characteristics of the population to determine Yin and Yang deficiency inhibits hyperthyroidism, physical fatigue, recovery speed after exercise, judgment of rehabilitation effect, risk of cardiac accident, probability of cancer occurrence, cancer tissue staging, cancer survival period, and possibility of cancer recurrence.
  • the method for evaluating the health status and changes of the present invention is simple, reliable, and easy to implement. It can be repeatedly measured and evaluated. It can be widely used for health assessment, health screening, health guidance, athlete screening and training, and sports rehabilitation guidance for the general population. , Disease warning, treatment dose and course adjustment, early detection of relapse and many other fields.

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Abstract

Procédé d'évaluation d'une réserve de santé, comprenant: l'obtention d'un signal de pouls humain, d'un signal sonore cardiaque ou d'un signal d'électrocardiographie, et la numérisation de celui-ci; la mise en œuvre d'une analyse variable composite d'une valeur de réserve de santé sur des données, et la formation d'une fonction monotone qui reflète un état de la réserve de santé; la mise en œuvre d'une analyse qualitative et quantitative sur un niveau de santé d'un sujet sur la base d'une distribution statistique des valeurs de réserve de santé d'un groupe de personnes; et la mise en œuvre d'un dépistage de maladies, d'une prédiction de santé ou d'une gestion d'exercice sur la base de la valeur de réserve de santé du sujet. L'invention concerne également un dispositif d'évaluation de la réserve de santé.
PCT/CN2018/102289 2018-07-03 2018-08-24 Procédé d'évaluation d'une réserve de santé, et dispositif et application de celui-ci WO2020006845A1 (fr)

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