WO2019237857A1 - 溶配药器 - Google Patents

溶配药器 Download PDF

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Publication number
WO2019237857A1
WO2019237857A1 PCT/CN2019/086112 CN2019086112W WO2019237857A1 WO 2019237857 A1 WO2019237857 A1 WO 2019237857A1 CN 2019086112 W CN2019086112 W CN 2019086112W WO 2019237857 A1 WO2019237857 A1 WO 2019237857A1
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WO
WIPO (PCT)
Prior art keywords
puncture
puncture device
hole
dispensing
dissolving
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Application number
PCT/CN2019/086112
Other languages
English (en)
French (fr)
Inventor
刘伟强
陈煊
赵罗瑞斯
Original Assignee
上海螭宿医药科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 上海螭宿医药科技有限公司 filed Critical 上海螭宿医药科技有限公司
Publication of WO2019237857A1 publication Critical patent/WO2019237857A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly

Definitions

  • the present disclosure relates to, but is not limited to, the field of infusion dispensing devices, and in particular, to a dissolving and dispensing device for automatically dissolving and dispensing drugs.
  • infusion solution dispensing basically uses a syringe and other simple forms for manual dispensing.
  • continuous preparation cannot be performed, the efficiency is low, the speed is slow, and the labor intensity is large.
  • the vial and the infusion were repeatedly punctured.
  • the rubber stopper of the container is easy to cause leakage and particle contamination.
  • the rubber stoppers of the vials and infusion containers are repeatedly punctured, which is prone to drug spillage.
  • the present disclosure provides a dissolving and dispensing device, including:
  • each of the trocar assemblies includes a plurality of trocars that are sequentially set, and the interior of the trocar is hollow and the A through hole in the sidewall;
  • a plurality of elastic infusion hoses, and the punctures in two of the puncture devices are in one-to-one correspondence with each other through the plurality of elastic infusion hoses.
  • each puncture device includes a first end and a second end, the first end is a puncture end for extending into the medicine container, and the second end is a connection end for communicating with the Flexible infusion hose connection.
  • the first end of the puncture device on the inner side protrudes from the first end of the puncture device on the outer side, and the puncture on the inner side
  • the protruding portion of the first end of the device is provided with a first through hole.
  • a first end of the puncture device located on the outer side is tapered, and is sealed and fixed with a side wall of the puncture device located on the inner side,
  • a second through hole is provided on a side wall of the puncture device located on the outside.
  • the puncture on the inner side is made of medical stainless steel, and the puncture on the outer side is made of medical plastic.
  • the first end of the puncture device on the inner side is located in the puncture device on the outer side.
  • a first through hole is provided on the side wall of the puncture device on the inner side
  • a second through hole is provided on the side wall of the puncture device on the outer side
  • the first and second through holes are provided.
  • the cross-sectional area of the first through-hole is smaller than the cross-sectional area of the second through-hole;
  • a first through hole is provided on a side wall of the puncture device on the inner side, and a second through hole and a third through hole are provided on the outer puncture device, and the first through hole is connected to the first through hole through a communication pipe.
  • Three through holes communicate.
  • the puncture on the inner side is made of medical plastic
  • the puncture on the outer side is made of medical stainless steel.
  • a connection end of the puncture device on the inner side protrudes from a connection end of the puncture device on the outer side.
  • each puncture assembly includes two punctures: a first puncture located on the outside and a second puncture located on the inside, and the dissolving and dispensing device includes two of the elastic infusion hoses;
  • the two first punctures of the two puncture assemblies communicate with each other through one of the two flexible infusion hoses, and the two second punctures of the two puncture assemblies are connected with each other through the two flexible infusion hoses.
  • the other is connected; or, the first puncture of one puncture assembly and the second puncture of the other puncture assembly are communicated through any one of the two flexible infusion hoses, and the first The two trocars communicate with the first trocar of another trocar assembly through the other of the two flexible infusion hoses.
  • At least one of the first puncture device and the second puncture device of the puncture device component is in communication with two of the elastic infusion hoses through a connecting member.
  • connection end of the second puncture device protrudes from the connection end of the first puncture device
  • the connecting piece is a tee, and the tee has a first connection port, a second connection port, and a third connection port, wherein the first connection port is in communication with the connection end of the first puncture device, so The second connection port is in communication with one of the elastic infusion hoses, the connection end of the second puncture device passes through the third connection port and is in communication with another of the elastic infusion hoses, and the A seal is formed between the side wall and the third connection port.
  • the lengths of the two first punctures are equal or different;
  • the lengths of the two second punctures are equal or different.
  • the medicine liquid in the medicine container is not easy to leak after puncture, and because only one puncture hole is formed in the rubber stopper, so the medicine container can rotate around the puncture device component during the dissolving or dispensing process, or the puncture device component relatively holds the medicine The container rotates, so that the liquid is continuously sprayed on the inner wall of the medicine container to accelerate the dissolution of the medicine.
  • this dissolving and dispensing device When using this dissolving and dispensing device to dissolve medicine, it is not necessary to repeatedly insert and withdraw the puncture device, which can realize a completely closed dissolving and dispensing process, which not only reduces the labor intensity of dispensing, but also realizes continuous preparation and improved efficiency; in addition, it avoids the leakage of liquid and The leakage caused the harm to the dispensing personnel; meanwhile, it reduced or avoided the pollution of particulates and secondary pollution of microorganisms.
  • the dissolving and dispensing device of this embodiment realizes automated, high-efficiency, pollution-free dispensing, and has a simple structure and low manufacturing cost.
  • FIG. 1 is a schematic structural diagram of a dissolving and dispensing device according to Embodiment 1 of the present disclosure
  • FIG. 2 is a schematic cross-sectional structure diagram of the dissolving and dispensing device shown in FIG. 1;
  • FIG. 3 is a schematic cross-sectional view of a partial structure of a puncture device component connected to a tee in the dissolving and dispensing device shown in FIG. 1;
  • FIG. 4 is a schematic partial cross-sectional view of a first structure of a puncture device assembly in a medicine dispensing device according to Embodiment 2 of the present disclosure
  • FIG. 5 is a schematic partial cross-sectional view of a second structure of a puncture device assembly in a medicine dispensing device according to Embodiment 2 of the present disclosure.
  • an embodiment of the present disclosure provides a dissolving and dispensing device, including: two puncture bases 1 and 2, two puncture components, and a plurality of flexible infusion hoses.
  • two trocar assemblies are respectively fixed on two trocar bases 1 and 2, each trocar assembly includes a plurality of trocars, and the interior of the trocar is hollow and forms a trocar channel.
  • Each puncture device is set in turn; the number of flexible infusion hoses is equal to the number of punctures in each puncture component, and the punctures in the two puncture components are in one-to-one correspondence through a plurality of flexible infusion hoses.
  • the two ends of the elastic infusion hose are respectively communicated with the two punctures in the puncture device components on both sides to form a dissolving and dispensing channel.
  • a puncture device assembly on the puncture device base 1 pierces a medicine-containing container (not shown), and a puncture device assembly on the puncture device base 2 pierces another medicine-containing container ( (Not shown)
  • the two medicine holding containers communicate with each other through an elastic infusion hose and a solution dispensing channel formed by a puncture channel;
  • each elastic infusion hose is configured to be squeezed by a peristaltic pump (not shown) connected to it,
  • the peristaltic pump can drive the fluid (such as liquid, gas, liquid-solid mixture) in the elastic infusion hose to flow, so that the contents in the two medicine-containing containers flow and mix with each other, so as to realize automatic dissolution and dispensing. How the specific peristaltic pump drives the fluid flow in the flexible infusion hose will not be repeated here.
  • a plurality of puncture devices in the puncture device assembly fixedly installed on the same puncture base 1 or 2 are sleeved in order, and have a sleeve structure, with a gap between the barrels, and the plurality of punctures are fixed at a distance from each other.
  • the puncture device base when the puncture device penetrates the rubber stopper of the medicine container, only one puncture hole is formed in the rubber stopper, the puncture is convenient, and the probability of leakage of the medicinal solution after the puncture is reduced.
  • the multiple puncture devices are set together, which can also reduce the space occupied by the puncture devices and reduce the chance of puncture operators stabbing operators.
  • the medicine container can rotate around the puncture device component during the dissolving or dispensing process, or the puncture device component rotates relative to the medicine container, so that the liquid is continuously sprayed on the medicine container.
  • the inner wall of the container accelerates the dissolution of the drug.
  • it is not necessary to repeatedly insert and withdraw the puncture device, so that a fully closed dissolving and dispensing process can be realized, which not only reduces the labor intensity of dispensing, but also realizes continuous preparation and improves the efficiency;
  • it can avoid causing leakage and leakage of liquid. Injuries caused by dispensing personnel; meanwhile, particle pollution and secondary pollution of microorganisms are reduced or avoided.
  • the elastic infusion hose is elastic.
  • the pump head of the peristaltic pump clamps the elastic infusion hose together with the clamp block, the pump head of the peristaltic pump is rotated, which can be squeezed by the rotation of the roller of the peristaltic pump to drive the elastic infusion hose.
  • the internal fluid continuously flows, which in turn provides continuous power to achieve dissolution.
  • each of the trocar assemblies includes two trocars nested with each other, for example, the trocar assembly fixed on the trocar base 1 includes a first The puncture device 7 and the second puncture device 5 located on the inside.
  • the puncture device assembly fixed on the puncture device base 2 includes a first puncture device 8 located on the outside and a second puncture device 6 located on the inside.
  • the dissolving and dispensing device includes two elastic infusion hoses 3-4, and the first punctures 7 and 8 of the two puncture components are connected through the elastic infusion hose 3 to form a dissolving and dispensing channel, and two puncture components
  • the second puncture devices 5 and 6 communicate with each other through the elastic infusion hose 4 to form another dissolving and dispensing channel.
  • the first puncture device of one puncture device and the second puncture device of the other puncture device can also be connected through an elastic infusion tube, for example, the first puncture device 7 and the second puncture device 6 are connected through an elastic infusion solution.
  • the flexible tube (such as the flexible infusion tube 3) is connected, and the first puncture device 8 and the second puncture device 5 are connected through another flexible infusion tube (such as the flexible infusion tube 4) to form two independent dissolving and dispensing channels. .
  • the first dissolution dispensing channel and the second dissolution dispensing channel are in parallel, so that when the two puncture components pierce the two medicine containing containers respectively, the two medicine containing containers communicate through the two medicine dispensing channels, and the two medicine dispensing channels
  • Different flow modes such as double co-direction, double reverse, and convection internal circulation
  • the puncture device has two ends, a first end and a second end, respectively.
  • the first end is used to extend into the medicine container, and the second end is used to connect with the elastic infusion tube and is the connection end.
  • the first end of the inner puncture is the puncture end and protrudes from the first end of the outer puncture, and the first end of the inner puncture is protruded from the outside.
  • a part of the puncture device is provided with a first through hole, and an outer puncture device is provided with a second through hole.
  • the first end (ie, the lower end) of the second puncture device 5 located on the inside is a sharp puncture end and
  • the first puncture device 7 protruding from the outer side, that is, the second puncture device 5 on the inner side is exposed to the outside of the puncture base 1 longer than the first puncture device 7 on the outer side, and the lower end of the second puncture device 5 is protruded from the first
  • a part of a puncture device 7 is provided with a first through hole 9.
  • the first through hole 9 may be provided on an end surface or a side surface of the lower end of the second puncture device 5, and a second passage is provided on the outer first puncture device 7.
  • the hole 11 and the second through hole 11 are provided on the tapered portion or the non-tapered portion of the first end (ie, the lower end) of the first puncture device 7.
  • the first end (ie, the lower end) of the second trocar 6 located on the inside is a sharp-shaped puncture end and
  • the first puncture device 8 protruding from the outer side, that is, the second puncture device 6 on the inner side is exposed to the outside of the puncture base 2 longer than the first puncture device 8 on the outer side, and the lower end of the second puncture device 6 is protruded from the first
  • a portion of a puncture device 8 is provided with a first through hole 10, and a first puncture device 8 on the outside is provided with a second through hole 12.
  • the puncture ends of the inner punctures 5 and 6 are sharp and convex.
  • the puncture component pierces the medicine container
  • the protruding sharp puncture ends pierce the medicine container, thereby making the entire puncture device assembly Enter the medicine container.
  • the lower ends of the second puncture devices 5 and 6 on the inner side protrude from the first puncture devices 7 and 8 on the outer side are respectively provided with first through holes 9 and 10
  • the first puncture devices 7 and 8 on the outer side are respectively provided with first through holes 9 and 10.
  • the two through holes 11 and 12 make the puncture channel inside the second puncture device 5 and 6 communicate with the outside world, and the passage between the inner wall of the first puncture device 7 and 8 and the outer wall of the second puncture device 5 and 6 communicate with the outside world.
  • the puncture channel inside the second puncture device 5, 6 and the passage between the inner wall of the first puncture device 7, 8 and the outer wall of the second puncture device 5, 6 can be It communicates with the medicine container, so that the two medicine containers can communicate with each other, and the medicine can be mixed.
  • first puncture device 7 and the second puncture device 5 and the first puncture device 8 and the second puncture device 6 are puncture devices with a long and short fit. This design can cooperate with the power of the dual-solution dispensing channel. In this way, more turbulent flow can be generated in the medicine container, which promotes the dissolution and mixing of the medicine.
  • the first end of the trocar located on the outer side is tapered, and is sealed and fixed with the side wall of the trocar located on the inner side.
  • the first ends of the first outer punctures 7 and 8 are tapered, so that the first ends of the outer first punctures 7 and 8 are respectively connected to the second inner sides of the first puncture 7 and 8.
  • the side walls of the puncture devices 5 and 6 are sealed and fixed, so that the first puncture device 7 and the second puncture device 5 on the inside, the first puncture device 8 and the second puncture device 6 are fixedly connected as a whole, which increases the strength of the puncture device assembly and The strength of the puncture end, and this structure allows the two puncture channels to be combined into a puncture end, so that when puncturing the rubber stopper of the medicine container, only a puncture hole is formed on the rubber stopper, avoiding the first puncture device 7 and the second puncture on the inner side Occurrence of a gap between the puncture end of the device 5, the puncture end of the first puncture device 8 and the second puncture device 6, the cutting of a rubber plug at the gap, and the like.
  • first ends of the outer first puncture devices 7 and 8 are tapered to reduce the puncture resistance and make the puncture operation labor-saving.
  • the puncture ends of the second puncture devices 5 and 6 on the inner side protrude, they mainly serve as puncture rubber plugs, and generally require higher strength of the puncture ends, and because of the size of the first puncture devices 5, 6 It is small, so the optional materials of the second puncture devices 5 and 6 are steel materials, such as medical stainless steel.
  • the first puncture devices 7 and 8 on the outer side have low strength requirements.
  • plastic materials can be used, such as medical plastic.
  • connection end of the inner trocar is protruded from the connection end of the outer trocar.
  • the connecting ends (the upper ends in the figure) of the second puncture devices 5, 6 on the inner side are respectively protruded from the connecting ends of the corresponding first puncture devices 7, 8 on the outer side, So that the first puncture device 7 and the second puncture device 5 are connected to one end of the elastic infusion hoses 3 and 4, respectively, and the first puncture device 8 and the second puncture device 6 are connected to the other ends of the elastic infusion hoses 3 and 4, respectively.
  • the two trocars of the trocar assembly are in communication with the elastic infusion hose through a connecting member.
  • the connecting member is a tee 13
  • the tee 13 has three connection ports, namely a first connection port 130, a second connection port 131, and a third connection port 132, wherein
  • the first connection port 130 is connected to the connection end of the first puncture device 7, and the second connection port 131 is connected to an elastic infusion tube 3. Since the first connection port 130 and the second connection port 131 communicate with each other through a channel inside the tee 13, the internal channel between the inner wall of the first puncture device 7 and the outer wall of the second puncture device 5 communicates with the elastic infusion tube 3. .
  • connection end of the second puncture device 5 is longer than the connection end of the first puncture device 7, and passes through the third connection port 132 and communicates with another elastic infusion tube 4.
  • a seal 14 is used to seal the outer wall of the second puncture device 5 and the inner wall of the third connection port 132.
  • a seal 14 is used to seal the outer wall of the first puncture device 7 and the inner wall of the first connection port 130.
  • a sealing member 14 is used to seal between the second connection port 131 and the elastic infusion tube 3.
  • the three-way pipe 13 is provided to realize the communication between the first puncture device 7 and the second puncture device 5 and the elastic infusion hoses 3 and 4, respectively.
  • the first puncture device 8 and the second puncture device 6 can also use a similar tee to communicate with the elastic infusion tubes 3 and 4.
  • the lengths of the first punctures 7, 8 of the two puncture assemblies are equal or unequal.
  • the lengths of the second punctures 5, 6 of the two puncture assemblies are equal or unequal.
  • the elastic infusion hose is made of medical PVC, TPE, TPU or medical silicone.
  • This embodiment provides a dissolving and dispensing device, which is different from the first embodiment in the structure of the puncture end of the puncture device assembly.
  • the first end of the inner puncture device (that is, the first end protruding into the medicine container) is located in the outer puncture device, and the outer puncture device
  • the first end of the device is a sharp-shaped puncture end.
  • the first end (lower end in the figure) of the second puncture device 5 on the inner side is located inside the first puncture device 7 on the outer side, that is, the second puncture device 5 on the inner side is exposed on the puncture base.
  • the outer length is shorter than the first puncture device 7 on the outer side. Since the first end of the second puncture device 5 is located inside the first puncture device 7, there is no need to set the first end of the second puncture device 5 into a sharp puncture. It is only necessary to set the first end of the first puncture device 7 into a sharp-shaped puncture end for puncturing the rubber stopper of the medicine container.
  • the second puncture device 5 and the first A hole is made in the puncture device 7.
  • the first puncture device 5 on the inner side is provided with a first through hole 9
  • the second puncture device 7 on the outer side is provided with a second through hole 11
  • the cross-sectional area of the first through hole 9 is It may be smaller than the cross-sectional area of the second through hole 11.
  • the first through-holes 9 and the second through-holes 11 are respectively disposed on the side walls of the second puncture device 5 and the first puncture device 7 and have corresponding positions.
  • the cross-sectional area of the second through-hole 11 is larger than the cross-sectional area of the first through-hole 9.
  • the first puncture device 5 on the inner side is provided with a first through hole 9
  • the second puncture device 7 on the outer side is provided with a second through hole 11 and a third through hole 16
  • the first The through-hole 9 communicates with the third through-hole 16 through a communication pipe 15.
  • the puncture channel in the second puncture device 5 communicates with the medicine container through the first through hole 9, the communication pipe 15, and the third through hole 16, and the second puncture device 5 and The internal passage between the first punctures 7 is communicated with the medicine container through the second through hole 11.
  • the second puncture device 5 on the inner side does not need to pierce the rubber plug, so its strength requirement is low.
  • a plastic material can be used, such as medical plastic.
  • the second puncture device 5 can also be made of steel, for example, it can be made of medical stainless steel.
  • Example 1 Solution formulation of powder vials and freeze-dried powder vials for vials
  • Example 1 The preparation process using the dissolving and dispensing device shown in Example 1 is:
  • two elastic infusion hoses 3-4 are respectively fixed in position on two peristaltic pumps of the automatic dispensing and dispensing system.
  • the two elastic infusion hoses 3-4 are clamped and fixed separately, which can be rolled by rollers. .
  • the automatic dispensing system drives the infusion container to move, so that the puncture device assembly at one end of the dissolving dispenser pierces into the infusion container.
  • the automatic dispensing system drives the movement of the vial drug container in the vial to insert the puncture device assembly in the other end of the vial into the vial container.
  • the depth of insertion is controlled by the automatic dispensing and dispensing system, so that the first puncture devices 7, 8 inserted into the vial bottled drug container have just penetrated the stopper of the vial bottled drug container, which can maximize the transfer of the drug.
  • Two peristaltic pumps simultaneously drive two flexible infusion hoses 3-4 to quickly pump the solution in the infusion container into the vial bottled drug container. The duration of the pump liquid is controlled by an intelligent software program.
  • one of the peristaltic pumps is reversed to drive the solution from the vial bottled drug container into the infusion container, and the other peristaltic pump continues to pump the solution from the infusion container into the vial bottled drug container, thus in the Xilin A circulating backflow state is formed between the bottled drug container and the infusion container, and a fierce circulating turbulence is formed in the Xilin bottled drug container.
  • the vial can also be rotated around the puncture unit to continuously and vigorously disturb the medicinal solution and undissolved medicine in the vial of the vial, and continuously and dynamically pump in and out of the vial to inject the vial in the vial
  • concentration of the solution in a limited volume is continuously and rapidly diluted, which accelerates the dissolution of the drug.
  • the two peristaltic pumps completely pump the medicine solution in the vial bottled medicine container into the infusion container. After the pumping liquid is over, the medicine dissolution operation in the vial bottled medicine container is ended.
  • the automatic dissolving and dispensing system drives the infusion container and the vial bottled drug container to move, so that the two puncture components are pulled out from the infusion container and the vial bottled drug container to complete the dissolving and dispensing operation.
  • the preparation process using the dissolving and dispensing device shown in the second embodiment is basically the same as the dissolving and dispensing device shown in the first embodiment.
  • Example 1 The preparation process using the dissolving and dispensing device shown in Example 1 is:
  • the peristaltic pump fixes two elastic infusion hoses 3-4 to the two peristaltic pumps of the automatic dispensing and dispensing system, respectively.
  • the two elastic infusion hoses 3-4 are clamped and fixed separately, which can be used for rollers. Crushing.
  • the automatic dispensing system drives the infusion container to move, so that the puncture device assembly at one end of the dissolving dispenser pierces into the infusion container.
  • the automatic dispensing system drives the movement of the vial drug container in the vial to insert the puncture device assembly in the other end of the vial into the vial container.
  • the depth of insertion is controlled by the automatic dispensing and dispensing system, so that the first puncture devices 7, 8 inserted into the vial bottled drug container have just penetrated the stopper of the vial bottled drug container, which can maximize the transfer of the drug.
  • the peristaltic pump is used to drive the flexible infusion tube 3 or 4 connected to the second puncture device 5 or 6 in the Xilin bottled drug container, and the medicinal solution in the Xilin bottled drug container is directly pumped into the infusion container.
  • Another dissolving and dispensing channel provides air pressure balance during operation, so that the medicinal solution can be easily and quickly drawn out.
  • the automatic dissolving and dispensing system drives the infusion container and the vial bottled drug container to move, so that the two puncture components are pulled out from the infusion container and the vial bottled drug container to complete the dissolving and dispensing operation.
  • the preparation process using the dissolving and dispensing device shown in the second embodiment is basically the same as the dissolving and dispensing device shown in the first embodiment.
  • Example 1 The preparation process using the dissolving and dispensing device shown in Example 1 is:
  • the peristaltic pump fixes two elastic infusion hoses 3-4 to the two peristaltic pumps of the automatic dispensing and dispensing system, respectively.
  • the two elastic infusion hoses 3-4 are clamped and fixed separately, which can be used for rollers. Crushing.
  • the automatic dispensing system drives the infusion container to move, allowing the puncture device component at one end of the dissolving dispenser to pierce the infusion container, while the automatic dispensing system drives the ampoule drug container to move, so that the puncture device at the other end of the dissolving dispenser is inserted into the ampoule drug container Inside, the depth of insertion is controlled by the automatic dispensing and dispensing system, allowing the second puncture device 5 or 6 inserted into the ampoule drug container to puncture to the bottom of the ampoule, which can maximize drug transfer.
  • the peristaltic pump is used to drive the flexible infusion tube 3 or 4 which is in communication with the second puncture device 5 or 6 in the ampoule bottled medicine container, and the medicinal solution in the ampoule bottled medicine container is directly pumped into the infusion container ;
  • Another dissolving and dispensing channel provides air pressure balance during operation, so that the medicinal solution can be easily drawn out quickly and pumped into the infusion container.
  • the automatic dissolving and dispensing system drives the infusion container and the ampoule drug container to move, so that the two puncture components are pulled out from the infusion container and the ampoule drug container to complete the dissolving and dispensing operation.
  • the peristaltic pump fixes two elastic infusion hoses 3-4 to the two peristaltic pumps of the automatic dispensing and dispensing system, respectively.
  • the two elastic infusion hoses 3-4 are clamped and fixed separately, which can be used for rollers. Crushing.
  • the automatic dispensing system drives the infusion container to move, allowing the puncture device component at one end of the dissolving dispenser to pierce the infusion container, while the automatic dispensing system drives the ampoule drug container to move, so that the puncture device at the other end of the dissolving dispenser is inserted into the ampoule bottle Inside, the depth of insertion is controlled by the automatic dispensing and dispensing system, allowing the first puncture device 7 or 8 inserted into the ampoule drug container to puncture to the bottom of the ampoule, which can maximize the transfer of the drug.
  • the peristaltic pump is used to drive the flexible infusion tube 3 or 4 connected to the first puncture device 7 or 8 in the ampoule bottled medicine container, and the medicinal solution in the ampoule bottled medicine container is directly pumped into the infusion container ;
  • Another dissolving and dispensing channel provides air pressure balance during operation, so that the medicinal solution can be easily drawn out quickly and pumped into the infusion container.
  • the automatic dissolving and dispensing system drives the infusion container and the ampoule drug container to move, so that the two puncture components are pulled out from the infusion container and the ampoule drug container to complete the dissolving and dispensing operation.
  • the design of the dissolving and dispensing device can make it easy to install in the automatic dissolving and dispensing system, and perform fast and automatic dissolution and preparation of medicines, which improves the efficiency of dissolving and dispensing medicines;
  • the puncture device components on the two puncture device bases are inserted into the infusion container and the vial (or ampoule) at the same time or separately, thereby forming a closed system interconnected within the dual-solution dispensing channel, which does not need to be repeatedly performed in the process of dissolving and preparing the drug.
  • the puncture greatly reduces the labor intensity of the medical staff; and the medical staff does not need to contact the drug and need not perform repeated puncture, which effectively reduces the harm of the drug to the medical staff during the dissolving and dispensing process, at the same time reduces the drug exposure and secondary pollution of the drug, and improves the infusion Safety is conducive to protecting the health of medical staff and patients;
  • the controllable two-way drive of two peristaltic pumps provides dual-power two-way fluid (such as liquid, gas, liquid-solid mixture) transportation during the process of dissolving and dispensing.
  • the fluid is in the infusion container, vial.
  • Different flow modes can be formed between the ampoule and the two channels (such as double co-direction, double reverse, internal circulation), which can form intense turbulence in the vial and ampoule, and the vial and ampoule can Rotate around the puncture device component, so that the medicine in the vial and ampoule can be quickly dissolved and mixed uniformly, and the air pressure in the vial, ampoule and infusion container can be balanced by the internal circulation flow method, which avoids the pressure difference during manual operation and single channel operation.
  • the balance makes it difficult to extract and inject the medicinal solution, so that the medicinal solution can be quickly dissolved and transferred to the infusion container, so that the dissolving efficiency is high and the effect of dissolving and dissolving the
  • the dissolving and dispensing device includes two dissolving and dispensing channels, that is, the puncture device assembly includes two puncture devices, and the dissolving and dispensing device includes two elastic infusion tubes.
  • the dissolving and dispensing device may also include only one dissolving and dispensing channel or three or more (including three) dissolving and dispensing channels.
  • the fluid in the dissolution dispensing channel can alternately flow in the forward and reverse directions to mix and dissolve the contents of the two medicine-containing containers for dissolution dispensing; when more than three dissolution dispensing channels are included
  • the process of dissolving and dispensing can be the same as or similar to the process of the above two dissolving and dispensing channels, and because three or more channels are formed between the two medicine holding containers, the efficiency of dissolving and dispensing is higher.
  • the dissolving and dispensing device of the present application can be used not only for dissolving medicine between an infusion container and a vial, between an infusion container and an ampoule, but also for other medicine-containing containers, such as between two infusion containers or between a vial and an ampoule. Dissolve between drugs and so on.
  • the punctures in the two puncture components are in one-to-one correspondence through a plurality of flexible infusion hoses
  • one puncture in a puncture component is in communication with one flexible infusion hose
  • One of the puncture devices in the other puncture device is connected.
  • the puncture device in the same position in the two puncture components may be the same, such as the innermost puncture device in the two puncture components. It can be a puncture device located at different positions of the two puncture components, for example, one of the puncture devices is an innermost puncture device of the puncture component, and the other puncture device is a puncture device of the puncture component.

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Abstract

一种溶配药器，用于自动溶配药，包括：两个穿刺器基座（1）和（2）；两个穿刺器组件，分别固定在两个穿刺器基座（1）和（2）上，每一个穿刺器组件均包括多个穿刺器，穿刺器内部中空并形成穿刺器通道，每一个穿刺器组件的多个穿刺器依次套设；和多个弹性输液软管，两个穿刺器组件中的穿刺器通过多个弹性输液软管一一对应相连通。

Description

溶配药器 技术领域
本公开涉及但不限于输液配药器械领域，特别是一种用于自动溶配药的溶配药器。
背景技术
目前的输液溶配药基本使用注射器及其他简易的形式手工配药，在配药的过程中，不能连续配制，效率低，速度慢，劳动强度大；西林瓶装药物配制时，由于多次穿刺西林瓶及输液容器的胶塞，容易造成漏液及微粒污染；在配制细胞毒性药物、化疗药物、易致敏药物、高活性等药物时，多次穿刺西林瓶及输液容器的胶塞，易产生药物溅出和挥发，对于配药人员造成长期伤害，可能带来不可逆的后果；多次穿刺西林瓶及输液容器的胶塞，由于针头暴露在非无菌环境，微生物会污染针头，污染的微生物可能会随着多次穿刺造成输液微生物二次污染；人工操作易受到操作人员精神状态和配药速度要求的影响。国家要求医疗机构配药中心的建立，需要配药方式的革新，以迄自动化、高效率、无污染的配药方式出现。
发明概述
以下是对本公开详细描述的主题的概述。本概述并非是为了限制权利要求的保护范围。
本公开提供了一种溶配药器，包括：
两个穿刺器基座；
两个穿刺器组件，其分别固定在两个所述穿刺器基座上，每一个所述穿刺器组件均包括依次套设的多个穿刺器，所述穿刺器内部中空且所述穿刺器的侧壁上具有通孔；和
多个弹性输液软管，两个所述穿刺器组件中的所述穿刺器通过多个所述弹性输液软管一一对应相连通。
可选地，每个穿刺器都包括第一端和第二端，所述第一端为穿刺端，用于伸入盛药容器内，所述第二端为连接端，用于与所述弹性输液软管连接。
可选地，所述穿刺器组件的相邻两个所述穿刺器中，内侧的所述穿刺器的第一端凸出于外侧的所述穿刺器的第一端，且内侧的所述穿刺器的第一端的凸出部分上设有第一通孔。
可选地，所述穿刺器组件的相邻两个所述穿刺器中，位于外侧的所述穿刺器的第一端呈锥形，并与位于内侧的所述穿刺器的侧壁密封固定，且位于外侧的所述穿刺器的侧壁上设有第二通孔。
可选地，所述穿刺器组件的相邻两个所述穿刺器中，内侧的所述穿刺器采用医用不锈钢制成，外侧的所述穿刺器采用医用塑胶制成。
可选地，所述穿刺器组件的相邻两个所述穿刺器中，内侧的所述穿刺器的第一端位于外侧的所述穿刺器内。
可选地，内侧的所述穿刺器的侧壁上开设有第一通孔，外侧的所述穿刺器的侧壁上设有第二通孔，且所述第一通孔和第二通孔的位置相对应，所述第一通孔的截面积小于所述第二通孔的截面积；或者
内侧的所述穿刺器的侧壁上开设有第一通孔，外侧的所述穿刺器上设有第二通孔和第三通孔，且所述第一通孔通过连通管道与所述第三通孔连通。
可选地，所述穿刺器组件的相邻两个所述穿刺器中，内侧的所述穿刺器采用医用塑胶制成，外侧的所述穿刺器采用医用不锈钢制成。
可选地，所述穿刺器组件的相邻两个所述穿刺器中，内侧的所述穿刺器的连接端凸出于外侧的所述穿刺器的连接端。
可选地，每个穿刺器组件都包括两个穿刺器：位于外侧的第一穿刺器和位于内侧的第二穿刺器，所述溶配药器包括两个所述弹性输液软管；
两个穿刺器组件的两个第一穿刺器通过两个所述弹性输液软管中的一个相连通，两个穿刺器组件的两个第二穿刺器通过两个所述弹性输液软管中的另一个相连通；或者，一个穿刺器组件的第一穿刺器与另一个穿刺器组件的第二穿刺器通过两个所述弹性输液软管中的任一个相连通，且该穿刺器组件 的第二穿刺器与另一个穿刺器组件的第一穿刺器通过两个所述弹性输液软管中的另一个相连通。
可选地，所述穿刺器组件的所述第一穿刺器与所述第二穿刺器中的至少一个通过连接件与两个所述弹性输液软管相连通。
可选地，所述第二穿刺器的连接端凸出于所述第一穿刺器的连接端，
所述连接件为三通管，所述三通管具有第一连接端口、第二连接端口和第三连接端口，其中所述第一连接端口与所述第一穿刺器的连接端连通，所述第二连接端口与一个所述弹性输液软管连通，所述第二穿刺器的连接端穿过第三连接端口并与另一个所述弹性输液软管连通，且所述第二穿刺器的侧壁与所述第三连接端口之间密封。
可选地，两个所述第一穿刺器的长度相等或不等；
或者，两个所述所述第二穿刺器的长度相等或不等。
本公开提供的溶配药器，具有如下有益效果：
本公开实施例提供的溶配药器，在溶配药过程中，由于安装在同一穿刺器上的两个穿刺器呈套筒结构，这样穿刺盛药容器的胶塞时在胶塞上仅形成一个穿刺孔，穿刺后盛药容器内的药液不易泄露，且由于在在胶塞上仅形成一个穿刺孔，这样盛药容器在溶配药过程中能够围绕穿刺器组件旋转，或穿刺器组件相对盛药容器旋转，使液体不断旋转地喷洒在盛药容器的内壁，加快药物的溶解。采用该溶配药器溶配药时，不需将穿刺器反复插入抽出，可实现全封闭的溶配药过程，既减轻了配药的劳动强度，同时实现了连续配制，效率提高；此外避免造成漏液及漏液对配药人员造成的伤害；同时减少或避免了微粒污染、微生物的二次污染。本实施例的溶配药器实现了自动化、高效率、无污染的配药，且结构简单，制造成本低。
本公开的其它特征和优点将在随后的说明书中阐述，并且，部分地从说明书中变得显而易见，或者通过实施本公开而了解。本公开的目的和其他优点可通过在说明书、权利要求书以及附图中所特别指出的结构来实现和获得。
附图概述
附图用来提供对本公开技术方案的进一步理解，并且构成说明书的一部分，与本申请的实施例一起用于解释本公开的技术方案，并不构成对本公开技术方案的限制。
图1是根据本公开实施例一的溶配药器的结构示意图；
图2是图1所示的溶配药器的剖面结构示意图；
图3是图1所示的溶配药器中穿刺器组件与三通管连接的局部结构的剖视示意图；
图4是根据本公开实施例二的溶配药器中穿刺器组件的第一种结构的局部剖视示意图；
图5是根据本公开实施例二的溶配药器中穿刺器组件的第二种结构的局部剖视示意图。
其中，图1-图5中附图标记与部件名称之间的关系为：
1-2穿刺器基座；3-4弹性输液软管；5、6第二穿刺器；7、8第一穿刺器；9-10第一通孔；11-12第二通孔；13三通管，130第一连接端口，131第二连接端口；132第三连接端口；14密封件；15连通通道，16第三通孔。
详述
下文中将结合附图对本公开的实施例进行详细说明。需要说明的是，在不冲突的情况下，本申请中的实施例及实施例中的特征可以相互任意组合。
实施例一
如图1-3所示，本公开的实施例提供了一种溶配药器，包括：两个穿刺器基座1和2、两个穿刺器组件和多个弹性输液软管。其中，两个穿刺器组件分别固定在两个穿刺器基座1和2上，每一个穿刺器组件均包括多个穿刺器，穿刺器内部中空并形成穿刺器通道，每一个穿刺器组件的多个穿刺器依次套设；弹性输液软管的数量与每一穿刺器组件中穿刺器的数量相等，且两个穿刺器组件中的穿刺器通过多个弹性输液软管一一对应相连通。
弹性输液软管的两端分别与两侧穿刺器组件中的两个穿刺器相连通，以 组成溶配药通道。在溶配药器使用时，一穿刺器基座1上的穿刺器组件刺穿一盛药容器(未示出)，另一穿刺器基座2上的穿刺器组件刺穿另一盛药容器(未示出)，两个盛药容器通过弹性输液软管及穿刺器通道形成的溶配药通道相连通；每一弹性输液软管配置成受与其连接的蠕动泵(未示出)的挤压，该蠕动泵可驱动弹性输液软管内的流体(如：液体、气体、液固混合体)流动，使两个盛药容器内的内容物互相流动、混合，以实现自动溶配药。具体蠕动泵如何驱动弹性输液软管内的流体流动，在此不再赘述。
其中，固定安装在同一穿刺器基座1或2上的穿刺器组件中的多个穿刺器依次套设，呈套筒结构，筒与筒之间有间隙，与多个穿刺器彼此间隔地固定在穿刺器基座上相比，该穿刺器组件穿刺入盛药容器的胶塞时在胶塞上仅形成一个穿刺孔，穿刺方便，且可减少刺穿后药液泄露的几率。此外，多个穿刺器套设在一起，还可减少穿刺器占用的空间，减少穿刺器刺伤操作人员的几率。
此外，由于在在胶塞上仅形成一个穿刺孔，这样盛药容器在溶配药过程中能够围绕着穿刺器组件旋转，或穿刺器组件相对盛药容器旋转，使液体不断旋转地喷洒在盛药容器的内壁，加快药物的溶解。且溶配药过程中，不需将穿刺器反复插入抽出，可实现全封闭的溶配药过程，既减轻了配药的劳动强度，同时实现了连续配制，效率提高；此外避免造成漏液及漏液对配药人员造成的伤害；同时减少或避免了微粒污染、微生物的二次污染。
此外，弹性输液软管具有弹性，当蠕动泵的泵头与夹块一起将该弹性输液软管夹紧后，转动蠕动泵泵头，可配合蠕动泵的滚轮转动挤压，驱动弹性输液软管内的流体不断流动，进而为实现溶配药提供持续的动力。
在图1、图2和图3所示的示例中，每一个穿刺器组件包括两个相互套设的穿刺器，如：固定在穿刺器基座1上的穿刺器组件包括位于外侧的第一穿刺器7和位于内侧的第二穿刺器5，固定在穿刺器基座2上的穿刺器组件包括位于外侧的第一穿刺器8和位于内侧的第二穿刺器6。相应地，溶配药器包括两个弹性输液软管3-4，两个穿刺器组件的第一穿刺器7、8通过弹性输液软管3相连通，组成一个溶配药通道，两个穿刺器组件的第二穿刺器5、6通过弹性输液软管4相连通，组成另一个溶配药通道。当然，也可以将一个穿刺 器组件的第一穿刺器与另一个穿刺器组件的第二穿刺器通过弹性输液软管相连通，如：第一穿刺器7与第二穿刺器6通过一个弹性输液软管(如弹性输液软管3)相连通，第一穿刺器8与第二穿刺器5通过另一个弹性输液软管(如弹性输液软管4)相连通，组成两个独立的溶配药通道。
第一溶配药通道和第二溶配药通道呈并联状态，这样当两个穿刺器组件分别刺穿两个盛药容器后，两个盛药容器通过两个溶配药通道连通，两个溶配药通道可根据需要形成不同的流动方式(如双同向、双反向、对流内循环)，以在盛药容器内形成激烈的湍流，便于盛药容器内的药物快速溶解、混合。
可选地，穿刺器具有两端，分别为第一端和第二端，第一端用于伸入盛药容器内，第二端用于与弹性输液软管连接，为连接端。
穿刺器组件的相邻两个穿刺器中，内侧的穿刺器的第一端为穿刺端并凸出于外侧的穿刺器的第一端，且内侧的穿刺器的第一端的凸出于外侧的穿刺器的部分上设有第一通孔，外侧的穿刺器上设有第二通孔。
在图1和图2所示的实施例中，固定在穿刺器基座1上的穿刺器组件中，位于内侧的第二穿刺器5的第一端(即下端)为尖锐状的穿刺端且凸出于外侧的第一穿刺器7，即内侧的第二穿刺器5暴露在穿刺器基座1外部的长度较外侧的第一穿刺器7长，且第二穿刺器5下端凸出于第一穿刺器7的部分上设有第一通孔9，第一通孔9可以设置在第二穿刺器5下端的端面或下端的侧面上，外侧的第一穿刺器7上设有第二通孔11，第二通孔11设置在第一穿刺器7第一端(即下端)的锥形部分或非锥形部分上。类似地，固定在穿刺器基座2上的穿刺器组件中，相互套设的两个穿刺器中，位于内侧的第二穿刺器6的第一端(即下端)为尖锐状的穿刺端且凸出于外侧的第一穿刺器8，即内侧的第二穿刺器6暴露在穿刺器基座2外部的长度较外侧的第一穿刺器8长，且第二穿刺器6下端凸出于第一穿刺器8的部分上设有第一通孔10，外侧的第一穿刺器8上设有第二通孔12。
内侧的第二穿刺器5和6的穿刺端为尖锐状且凸出，在穿刺器组件刺穿盛药容器时，该凸出的尖锐的穿刺端刺穿盛药容器，进而使得整个穿刺器组件进入盛药容器内。内侧的第二穿刺器5、6下端凸出于外侧的第一穿刺器7、8的部分上分别设有第一通孔9、10，外侧的第一穿刺器7、8上分别设有第 二通孔11、12，使得第二穿刺器5、6内部的穿刺器通道与外界连通，第一穿刺器7、8的内壁与第二穿刺器5、6的外壁之间的通道与外界连通，以便穿刺器组件刺穿盛药容器后，第二穿刺器5、6内部的穿刺器通道以及第一穿刺器7、8的内壁与第二穿刺器5、6的外壁之间的通道均能够与盛药容器连通，从而使两个盛药容器相连通，能够进行药物的混合。
每一个穿刺器组件中，第一穿刺器7与第二穿刺器5以及第一穿刺器8与第二穿刺器6为长短配合的穿刺器，这种设计，可以在双溶配药通道动力的配合下，能够在盛药容器内产生更剧烈的湍流，促进药物溶解、混合。
可选地，穿刺器组件的相邻两个穿刺器中，位于外侧的穿刺器的第一端呈锥形，并与位于内侧的穿刺器的侧壁密封固定。在图1和图2所示的实施例中，外侧的第一穿刺器7、8的第一端呈锥形，方便外侧的第一穿刺器7、8的第一端分别与内侧的第二穿刺器5、6的侧壁密封固定，使第一穿刺器7与内侧的第二穿刺器5、第一穿刺器8与第二穿刺器6固定连接为一体，增加了穿刺器组件的强度以及穿刺端的强度，且此结构使两个穿刺通道合并成一个穿刺端，这样穿刺入盛药容器的胶塞时仅在胶塞上形成一个穿刺孔，避免第一穿刺器7与内侧的第二穿刺器5的穿刺端、第一穿刺器8与第二穿刺器6的穿刺端之间存在间隙、间隙处切割胶塞等情况发生。
此外，外侧的第一穿刺器7、8的第一端呈锥形，减小穿刺阻力，使得刺穿操作省力。
穿刺器组件中，由于内侧的第二穿刺器5、6的穿刺端凸出，主要起刺穿胶塞的作用，对穿刺端的强度一般要求较高，且由于第一穿刺器5、6的尺寸较小，所以第二穿刺器5、6可选材料为钢材料，如可以采用医用不锈钢制成。外侧的第一穿刺器7、8的强度要求低，一般可采用塑胶材料，如可以采用医用塑胶制成。
溶配药器工作时，根据溶配药物调整穿刺器插入盛药容器内的位置，如使第二穿刺器5、6触及盛药容器的瓶底或者刚刺穿胶塞等，以使药物更好地实现交换。
可选地，穿刺器组件的相邻两个穿刺器中，内侧的穿刺器的连接端凸出于外侧的穿刺器的连接端。
具体地，如图1-3所示，内侧的第二穿刺器5、6的连接端(图中的上端)分别凸出于其所对应的外侧的第一穿刺器7、8的连接端，以便第一穿刺器7和第二穿刺器5分别与弹性输液软管3、4的一端连接，第一穿刺器8和第二穿刺器6分别与弹性输液软管3、4的另一端连接。
可选地，穿刺器组件的两个穿刺器通过连接件与弹性输液软管相连通。
具体地，如图1-3所示，连接件为三通管13，三通管13具有三个连接端口，分别为第一连接端口130、第二连接端口131和第三连接端口132，其中，第一连接端口130与第一穿刺器7的连接端连接，第二连接端口131与一个弹性输液软管3连通。由于第一连接端口130和第二连接端口131通过三通管13内部的通道连通，使得第一穿刺器7的内壁与第二穿刺器5的外壁之间的内部通道与弹性输液软管3连通。第二穿刺器5的连接端较第一穿刺器7的连接端长，其穿过第三连接端口132并与另一个弹性输液软管4连通。且采用一个密封件14将第二穿刺器5的外壁与第三连接端口132的内壁之间进行密封，采用一个密封件14将第一穿刺器7的外壁与第一连接端口130的内壁之间进行密封，采用一个密封件14将第二连接端口131与弹性输液软管3之间进行密封。
通过设置三通管13，实现了第一穿刺器7与第二穿刺器5分别与弹性输液软管3和4的连通。第一穿刺器8与第二穿刺器6也可以采用类似的三通管实现与弹性输液软管3和4的连通。
可选地，两个穿刺器组件的第一穿刺器7、8的长度相等或不相等。
可选地，两个穿刺器组件的第二穿刺器5、6的长度相等或不相等。
可选地，弹性输液软管采用医用PVC、TPE、TPU或医用硅胶制成。
实施例二
本实施例提供了一种溶配药器，其与实施例一不同之处在于：穿刺器组件的穿刺端的结构。
在本实施例中，穿刺器组件的相邻两个穿刺器中，内侧的穿刺器的第一 端(即伸入盛药容器内的第一端)位于外侧的穿刺器内，且外侧的穿刺器的第一端为尖锐状的穿刺端。
如图4和图5所示，内侧的第二穿刺器5的第一端(图中的下端)位于外侧的第一穿刺器7内，即内侧的第二穿刺器5暴露在穿刺器基座外部的长度较外侧的第一穿刺器7短，由于第二穿刺器5的第一端位于第一穿刺器7内部，因此，无需将第二穿刺器5的第一端设置成尖锐状的穿刺端，而是仅需将第一穿刺器7的第一端设置成尖锐状的穿刺端，用于刺穿盛药容器的胶塞。
为实现第二穿刺器5的穿刺器通道以及第二穿刺器5与第一穿刺器7之间的内部通道连通至外界(如与盛药容器连通)，需在第二穿刺器5和第一穿刺器7上开孔。
在图4所示的示例中，内侧的第二穿刺器5上开设有第一通孔9，外侧的第一穿刺器7上设有第二通孔11，且第一通孔9的截面积可以小于第二通孔11的截面积。可选地，第一通孔9与第二通孔11分别设置在第二穿刺器5与第一穿刺器7的侧壁上，且位置相对应。
第二通孔11的截面积大于第一通孔9的截面积，这样穿刺器组件刺穿盛药容器后，第二穿刺器5内的穿刺器通道以及第二穿刺器5与第一穿刺器7之间的内部通道均能够通过该第二通孔11实现与盛药容器的连通，使盛药容器内的药物在第二穿刺器5内的穿刺器通道、第二穿刺器5与第一穿刺器7之间的内部通道以及盛药容器之间流动。
在图5所示的示例中，内侧的第二穿刺器5上开设有第一通孔9，外侧的第一穿刺器7上设有第二通孔11和第三通孔16，且第一通孔9通过连通管道15与第三通孔16连通。
穿刺器组件刺穿盛药容器后，第二穿刺器5内的穿刺器通道通过第一通孔9、连通管道15以及第三通孔16实现与盛药容器的连通，第二穿刺器5与第一穿刺器7之间的内部通道通过第二通孔11实现与盛药容器的连通。
本实施例的穿刺器组件中，由于，外侧的第一穿刺器7
内侧的第二穿刺器5不需要刺穿胶塞，故其强度要求低，一般可采用塑 胶材料，如可以采用医用塑胶制成。当然，第二穿刺器5也可以选用钢材料，如可以采用医用不锈钢制成。
下面结合具体示例说明本实施例的溶配药器进行溶配药的过程。
示例一：粉针、冻干粉针西林瓶装药物的溶配药方案
采用实施例一所示的溶配药器进行配制的过程为
进行溶配药时，将两根弹性输液软管3-4分别对位固定在自动溶配药系统两个蠕动泵上，两根弹性输液软管3-4被分别夹紧固定，可供滚轮碾压。
自动溶配药系统驱动输液容器移动，使溶配药器一端的穿刺器组件刺入输液容器内，同时自动配药系统驱动西林瓶装药物容器移动，使溶配药器另一端的穿刺器组件插入西林瓶装药物容器内，插入的深度由自动溶配药系统控制，使插入西林瓶装药物容器的第一穿刺器7、8刚刺穿西林瓶装药物容器的胶塞，这样能最大限度转移药物。两个蠕动泵同时驱动两根弹性输液软管3-4，将输液容器内的溶液快速泵入西林瓶装药物容器中，泵液的持续时间由智能软件程序控制。
泵入结束后，将其中一个蠕动泵反向，驱动溶液从西林瓶装药物容器内泵入输液容器中，另一个蠕动泵则继续从输液容器中向西林瓶装药物容器内泵入溶液，从而在西林瓶装药物容器和输液容器之间形成循环回流状态，并在西林瓶装药物容器内形成激烈的循环湍流。在溶配过程中，还可将西林瓶围绕穿刺器组件转动，持续剧烈扰动西林瓶装药物容器内药液和未溶解的药物，且通过输液持续动态的泵入、泵出，使西林瓶装药物容器内有限容积的溶液浓度被不断快速稀释，从而使药物加快溶解。药物完全溶解后，两个蠕动泵将西林瓶装药物容器内的药液完全泵入输液容器内，泵液结束后，西林瓶装药物容器内的药物溶配操作结束。
自动溶配药系统驱动输液容器和西林瓶装药物容器移动，使两个穿刺器组件从输液容器和西林瓶装药物容器中拔出，完成药物溶配操作。
采用实施例二所示的溶配药器进行配制的过程与实施例一所示的溶配药器基本一致。
示例二：液体西林瓶配药方案
采用实施例一所示的溶配药器进行配制的过程为
进行溶配药时，蠕动泵将两根弹性输液软管3-4分别对位固定在自动溶配药系统两个蠕动泵上，两根弹性输液软管3-4被分别夹紧固定，可供滚轮碾压。
自动溶配药系统驱动输液容器移动，使溶配药器一端的穿刺器组件刺入输液容器内，同时自动配药系统驱动西林瓶装药物容器移动，使溶配药器另一端的穿刺器组件插入西林瓶装药物容器内，插入的深度由自动溶配药系统控制，使插入西林瓶装药物容器的第一穿刺器7、8刚刺穿西林瓶装药物容器的胶塞，这样能最大限度转移药物。通过智能软件程序控制，用蠕动泵驱动与西林瓶装药物容器内的第二穿刺器5或6相连通的弹性输液软管3或4，将西林瓶装药物容器内的药液直接泵入输液容器中；另一溶配药通道则在操作过程中提供气压平衡，使药液很容易迅速抽出。泵液结束后，西林瓶装药物容器内的药物配制操作结束。
自动溶配药系统驱动输液容器和西林瓶装药物容器移动，使两个穿刺器组件从输液容器和西林瓶装药物容器中拔出，完成药物溶配操作。
采用实施例二所示的溶配药器进行配制的过程与实施例一所示的溶配药器基本一致。
示例三：安瓿瓶配药方案
采用实施例一所示的溶配药器进行配制的过程为
进行溶配药时，蠕动泵将两根弹性输液软管3-4分别对位固定在自动溶配药系统两个蠕动泵上，两根弹性输液软管3-4被分别夹紧固定，可供滚轮碾压。
自动溶配药系统驱动输液容器移动，使溶配药器一端的穿刺器组件刺入输液容器内，同时自动配药系统驱动安瓿瓶装药物容器移动，使溶配药器另一端的穿刺器组件插入安瓿瓶装药物容器内，插入的深度由自动溶配药系统控制，使插入安瓿瓶装药物容器的第二穿刺器5或6刺至安瓿瓶底，这样能最大限度转移药物。通过智能软件程序控制，用蠕动泵驱动与安瓿瓶装药物容器内的第二穿刺器5或6相连通的弹性输液软管3或4，将安瓿瓶装药物容器内的药液直接泵入输液容器中；另一溶配药通道则在操作过程中提供气压 平衡，使药液很容易迅速抽出并泵入输液容器中。泵液结束后，安瓿瓶装药物容器内的药物配制操作结束。
自动溶配药系统驱动输液容器和安瓿瓶装药物容器移动，使两个穿刺器组件从输液容器和安瓿瓶装药物容器中拔出，完成药物溶配操作。
采用实施例二所示的溶配药器进行配制的过程
进行溶配药时，蠕动泵将两根弹性输液软管3-4分别对位固定在自动溶配药系统两个蠕动泵上，两根弹性输液软管3-4被分别夹紧固定，可供滚轮碾压。
自动溶配药系统驱动输液容器移动，使溶配药器一端的穿刺器组件刺入输液容器内，同时自动配药系统驱动安瓿瓶装药物容器移动，使溶配药器另一端的穿刺器组件插入安瓿瓶装药物容器内，插入的深度由自动溶配药系统控制，使插入安瓿瓶装药物容器的第一穿刺器7或8刺至安瓿瓶底，这样能最大限度转移药物。通过智能软件程序控制，用蠕动泵驱动与安瓿瓶装药物容器内的第一穿刺器7或8相连通的弹性输液软管3或4，将安瓿瓶装药物容器内的药液直接泵入输液容器中；另一溶配药通道则在操作过程中提供气压平衡，使药液很容易迅速抽出并泵入输液容器中。泵液结束后，安瓿瓶装药物容器内的药物配制操作结束。
自动溶配药系统驱动输液容器和安瓿瓶装药物容器移动，使两个穿刺器组件从输液容器和安瓿瓶装药物容器中拔出，完成药物溶配操作。
本公开上述两个实施例的溶配药器具有如下有益效果：
溶配药器的设计可使其便于安装在自动溶配药系统中，进行快速、自动化的溶解配制药物，提高了溶配药物的效率；
两个穿刺器基座上的穿刺器组件同时或分别刺入输液容器和西林瓶(或安瓿瓶)中，从而形成双溶配药通道内联通的封闭系统，在溶解配制药物过程中，无需反复进行穿刺，大大降低了医护人员的劳动强度；且医护人员无需接触药物，无需反复进行穿刺，有效降低溶配药过程中药物对医护人员的伤害，同时降低了药物暴露和药物二次污染，提高了输液安全性，有利于保护医护人员和患者的健康；
通过两个蠕动泵的可控双向驱动，在溶配药过程中提供双动力双向流体 (如：液体、气体、液固混合体)输送，在溶配药物过程中，流体在输液容器、西林瓶、安瓿瓶及两个通道之间可根据需要形成不同的流动方式(如双同向、双反向、内循环)，可在西林瓶、安瓿瓶内形成激烈的湍流，且西林瓶、安瓿瓶可围绕穿刺器组件旋转，使西林瓶、安瓿瓶内药物快速溶解、混合均匀，并能通过内循环的流动方式平衡西林瓶、安瓿瓶和输液容器内气压，避免人工操作和单通道操作时气压不平衡造成药液抽出注入困难的情况，从而可快速溶配转移药液至输液容器内，使得溶配效率高，溶配药的效果好。
需要说明的是，上述实施例中，溶配药器包括两个溶配药通道，即穿刺器组件包括两个穿刺器，溶配药器包括两个弹性输液软管。当然，溶配药器也可以仅包括一个溶配药通道或三个以上(包括三个)的溶配药通道。当仅包括一个溶配药通道时，可通过使溶配药通道内的流体交替进行正反向流动来使两个盛药容器内的内容物混合溶解，进行溶配药；当包括三个以上的溶配药通道时，其溶配药过程可与上述两个溶配药通道的过程相同或相似，且由于在两个盛药容器之间形成了三个或三个以上的通道，使得溶配药的效率更高。
本申请的溶配药器不仅可用于输液容器与西林瓶之间、输液容器与安瓿瓶之间的溶配药，还可以用于其他盛药容器，如两个输液容器之间或者西林瓶与安瓿瓶之间的溶配药等。
需要说明的是，本申请中的术语“多个”指两个或更多个。
需要说明的是，本申请中，“两个穿刺器组件中的穿刺器通过多个弹性输液软管一一对应相连通”仅指一个穿刺器组件中的一个穿刺器通过一个弹性输液软管与另一个穿刺器组件中的一个穿刺器连通，至于连通的两个穿刺器，既可以是两个穿刺器组件中位于同一位置的穿刺器，如两个穿刺器组件中最内侧的穿刺器，也可以是两个穿刺器组件中位于不同位置的穿刺器，如其中一个穿刺器是一个穿刺器组件中最内侧的穿刺器，另一个穿刺器是穿刺器组件中外侧的穿刺器。
以上公开内容规定为说明性的而不是穷尽性的。对于本领域技术人员来说，本说明书将暗示许多变化和可选择方案。所有这些可选择方案和变化规定为被包括在本权利要求的范围内。本领域技术人员应认识到此处的实施方 案的其它等效变换，这些等效变换也规定为由本权利要求所包括。
在此完成了对本申请可选择的实施方案的描述。本领域技术人员可认识到此处的实施例仅用于说明本申请，其中溶配药器的元件或结构等都是可以有所变化的，凡是在本申请技术方案的基础上进行的等同变换和改进，均不应被排除在本申请的保护范围之外。
虽然本公开所揭露的实施方式如上，但所述的内容仅为便于理解本公开而采用的实施方式，并非用以限定本公开。任何本公开所属领域内的技术人员，在不脱离本公开所揭露的精神和范围的前提下，可以在实施的形式及细节上进行任何的修改与变化，但本公开的专利保护范围，仍须以所附的权利要求书所界定为准。

Claims (13)

  1. 一种溶配药器，包括：
    两个穿刺器基座；
    两个穿刺器组件，其分别固定在两个所述穿刺器基座上，每一个所述穿刺器组件均包括依次套设的多个穿刺器，所述穿刺器内部中空且所述穿刺器的侧壁上具有通孔；和
    多个弹性输液软管，两个所述穿刺器组件中的所述穿刺器通过多个所述弹性输液软管一一对应相连通。
  2. 如权利要求1所述的溶配药器，其中，每个穿刺器都包括第一端和第二端，所述第一端为穿刺端，用于伸入盛药容器内，所述第二端为连接端，用于与所述弹性输液软管连接。
  3. 如权利要求2所述的溶配药器，其中，所述穿刺器组件的相邻两个所述穿刺器中，内侧的所述穿刺器的第一端凸出于外侧的所述穿刺器的第一端，且内侧的所述穿刺器的第一端的凸出部分上设有第一通孔。
  4. 如权利要求3所述的溶配药器，其中，所述穿刺器组件的相邻两个所述穿刺器中，位于外侧的所述穿刺器的第一端呈锥形，并与位于内侧的所述穿刺器的侧壁密封固定，且位于外侧的所述穿刺器的侧壁上设有第二通孔。
  5. 如权利要求4所述的溶配药器，其中，所述穿刺器组件的相邻两个所述穿刺器中，内侧的所述穿刺器采用医用不锈钢制成，外侧的所述穿刺器采用医用塑胶制成。
  6. 如权利要求2所述的溶配药器，其中，所述穿刺器组件的相邻两个所述穿刺器中，内侧的所述穿刺器的第一端位于外侧的所述穿刺器内。
  7. 如权利要求6所述的溶配药器，其中，
    内侧的所述穿刺器的侧壁上开设有第一通孔，外侧的所述穿刺器的侧壁上设有第二通孔，且所述第一通孔和第二通孔的位置相对应，所述第一通孔的截面积小于所述第二通孔的截面积；或者
    内侧的所述穿刺器的侧壁上开设有第一通孔，外侧的所述穿刺器上设有 第二通孔和第三通孔，且所述第一通孔通过连通管道与所述第三通孔连通。
  8. 如权利要求7所述的溶配药器，其中，所述穿刺器组件的相邻两个所述穿刺器中，内侧的所述穿刺器采用医用塑胶制成，外侧的所述穿刺器采用医用不锈钢制成。
  9. 如权利要求2-8中任一项所述的溶配药器，其中，所述穿刺器组件的相邻两个所述穿刺器中，内侧的所述穿刺器的连接端凸出于外侧的所述穿刺器的连接端。
  10. 如权利要求2-8中任一项所述的溶配药器，其中，每个穿刺器组件都包括两个穿刺器：位于外侧的第一穿刺器和位于内侧的第二穿刺器，所述溶配药器包括两个所述弹性输液软管；
    两个穿刺器组件的两个第一穿刺器通过两个所述弹性输液软管中的一个相连通，两个穿刺器组件的两个第二穿刺器通过两个所述弹性输液软管中的另一个相连通；或者，一个穿刺器组件的第一穿刺器与另一个穿刺器组件的第二穿刺器通过两个所述弹性输液软管中的任一个相连通，且该穿刺器组件的第二穿刺器与另一个穿刺器组件的第一穿刺器通过两个所述弹性输液软管中的另一个相连通。
  11. 如权利要求10所述的溶配药器，其中，所述穿刺器组件的所述第一穿刺器与所述第二穿刺器中的至少一个通过连接件与两个所述弹性输液软管相连通。
  12. 如权利要求11所述的溶配药器，其中，所述第二穿刺器的连接端凸出于所述第一穿刺器的连接端，
    所述连接件为三通管，所述三通管具有第一连接端口、第二连接端口和第三连接端口，其中所述第一连接端口与所述第一穿刺器的连接端连通，所述第二连接端口与一个所述弹性输液软管连通，所述第二穿刺器的连接端穿过第三连接端口并与另一个所述弹性输液软管连通，且所述第二穿刺器的侧壁与所述第三连接端口之间密封。
  13. 如权利要求10所述的溶配药器，其中，两个所述第一穿刺器的长度相等或不等；
    或者，两个所述第二穿刺器的长度相等或不等。
PCT/CN2019/086112 2018-06-12 2019-05-09 溶配药器 WO2019237857A1 (zh)

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