WO2019235542A1 - 光学分析システム及び光学分析方法 - Google Patents
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Abstract
Description
本開示の第1実施形態について主に説明する。第1実施形態では、化学反応に関する情報は、主に生成物の収率である。第1実施形態では、生成物の収率に主に着目して説明を行う。初めに、従来技術の問題点について説明する。
本開示の第2実施形態について主に説明する。第2実施形態では、化学反応に関する情報は、主に生成物ABの光学異性に関する情報である。第2実施形態では、生成物ABの光学異性に関する情報に主に着目して説明を行う。初めに、従来技術の問題点について説明する。
本開示の第3実施形態について主に説明する。第3実施形態では、化学反応に関する情報は、主に化学反応に関するパラメータの経時変化である。第3実施形態では、化学反応に関するパラメータの経時変化に主に着目して説明を行う。化学反応に関するパラメータは、例えば生成物ABの収率を含む。
10 光学測定装置
11 照射部
12 検出部
13 制御部
14 通信部
15 記憶部
16 演算部
17 記憶部
20 光学分析装置
21 通信部
22 演算部
23 表示部
24 操作部
25 記憶部
30 化学反応系
31 送液ポンプ
32 フロー化学反応チューブ(流路)
33 マイクロリアクター
40 データ通信ケーブル
A 第1原料
B 第2原料
AB、AB1、AB2 生成物
C 混合物
c1 化合物
c2 光学異性体
L1、L1a、L1b、L1c 照射光
L2、L2a、L2b、L2c 測定光
P1、P2、P3、P4、P5 位置
t1、t2、t3、t4、t5 反応時間
Claims (14)
- 第1原料と第2原料とを合成して生成物を得る化学反応系において、合成開始前の前記第1原料及び前記第2原料それぞれに照射光を照射し、かつ前記第1原料、前記第2原料、及び前記生成物を含む合成開始後の混合物に照射光を照射する照射部と、
前記照射部によって照射された前記照射光に基づく測定光であって、前記第1原料、前記第2原料、及び前記混合物それぞれの分光スペクトルに関する情報を含む前記測定光を検出する検出部と、
前記第1原料、前記第2原料、及び前記混合物それぞれの分光スペクトルを算出し、各分光スペクトルに基づいて、前記生成物の分光スペクトルを算出する演算部と、
を備える、
光学分析システム。 - 前記生成物は、異性化していない化合物、及び互いに光学異性体の関係を有する一対の化合物のうちいずれかを含む、
請求項1に記載の光学分析システム。 - 前記照射部は、前記混合物に前記照射光を複数の反応時間ごとに照射し、
前記演算部は、複数の反応時間ごとに算出された前記生成物の前記分光スペクトルに基づいて、化学反応に関するパラメータの経時変化を算出する、
請求項1に記載の光学分析システム。 - 前記化学反応に関するパラメータは、前記生成物の収率を含む、
請求項3に記載の光学分析システム。 - 前記演算部は、前記混合物の分光スペクトルから前記第1原料及び前記第2原料それぞれの分光スペクトルを差し引くことで、前記生成物の分光スペクトルを算出する、
請求項1乃至4のいずれか1項に記載の光学分析システム。 - 前記化学反応系は、前記第1原料、前記第2原料、及び前記混合物それぞれが流路の内部を流れるフロー式の合成反応系を含む、
請求項1乃至5のいずれか1項に記載の光学分析システム。 - 前記照射部は、前記混合物が流れる前記流路に沿った複数の位置それぞれにおいて前記照射光を照射する、
請求項6に記載の光学分析システム。 - 前記第1原料及び前記第2原料それぞれは、アミノ酸を含み、
前記生成物は、ペプチド結合により形成された化合物を含む、
請求項1乃至7のいずれか1項に記載の光学分析システム。 - 前記測定光が有する波長帯域は、1800nmから2500nmまでの近赤外領域に含まれる、
請求項1乃至8のいずれか1項に記載の光学分析システム。 - 前記測定光は、前記第1原料、前記第2原料、及び前記混合物それぞれを透過した、前記照射光に基づく透過光を含み、
前記分光スペクトルは、光吸収スペクトルを含む、
請求項1乃至9のいずれか1項に記載の光学分析システム。 - 第1原料と第2原料とを合成して生成物を得る化学反応系において、合成開始前の前記第1原料及び前記第2原料それぞれに照射光を照射し、かつ前記第1原料、前記第2原料、及び前記生成物を含む合成開始後の混合物に照射光を照射するステップと、
照射された前記照射光に基づく測定光であって、前記第1原料、前記第2原料、及び前記混合物それぞれの分光スペクトルに関する情報を含む前記測定光を検出するステップと、
前記第1原料、前記第2原料、及び前記混合物それぞれの分光スペクトルを算出し、各分光スペクトルに基づいて、前記生成物の分光スペクトルを算出するステップと、
を含む、
光学分析方法。 - 前記生成物は、異性化していない化合物、及び互いに光学異性体の関係を有する一対の化合物のうちいずれかを含む、
請求項11に記載の光学分析方法。 - 前記照射光を照射するステップにおいて、前記混合物に前記照射光を複数の反応時間ごとに照射し、
複数の反応時間ごとに算出された前記生成物の前記分光スペクトルに基づいて、化学反応に関するパラメータの経時変化を算出するステップを含む、
請求項11に記載の光学分析方法。 - 前記生成物の分光スペクトルを算出するステップにおいて、前記混合物の分光スペクトルから前記第1原料及び前記第2原料それぞれの分光スペクトルを差し引くことで、前記生成物の分光スペクトルを算出する、
請求項11乃至13のいずれか1項に記載の光学分析方法。
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CN112236667A (zh) | 2021-01-15 |
US20210247302A1 (en) | 2021-08-12 |
AU2019283225A1 (en) | 2021-01-07 |
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EP3816610B1 (en) | 2023-05-03 |
EP3816610A4 (en) | 2022-01-26 |
EP3816610A1 (en) | 2021-05-05 |
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