WO2019232077A1 - Drug delivery methods and systems - Google Patents
Drug delivery methods and systems Download PDFInfo
- Publication number
- WO2019232077A1 WO2019232077A1 PCT/US2019/034432 US2019034432W WO2019232077A1 WO 2019232077 A1 WO2019232077 A1 WO 2019232077A1 US 2019034432 W US2019034432 W US 2019034432W WO 2019232077 A1 WO2019232077 A1 WO 2019232077A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bioactive agent
- disposable part
- agent
- reservoir
- reusable part
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/10—Wearable devices, e.g. garments, glasses or masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0272—Electro-active or magneto-active materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/14—Detection of the presence or absence of a tube, a connector or a container in an apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
Definitions
- Medicinal drugs are given to people to manage or improve their health for a variety of reasons, such as to prevent or treat a medical condition or disease such as diabetes, Parkinson’s disease, ulcerative colitis, or to manage nicotine or another addiction or dependency, or to manage pain.
- a medical condition or disease such as diabetes, Parkinson’s disease, ulcerative colitis, or to manage nicotine or another addiction or dependency, or to manage pain.
- Some medicinal drugs are rapidly metabolized by the body. As a result, multiple doses of the drug over a period of time are often needed to provide a desired effect.
- medicinal drugs can also have negative side-effects on the body that can range from irritating to life-threatening.
- a person’s body can develop tolerance to a drug, experience a diminished response to the drug after taking it for a period of time, and require higher doses to have an effect, resulting in increased drug use and additional side-effects. It is therefore beneficial to a person taking a drug to minimize the amount of drug he or she takes to prevent or minimize tolerance and other unwanted side-effects while still receiving the desired therapeutic effect from the drug.
- Tobacco use (such as smoking) causes serious health problems and can lead to premature death.
- CDC United States Center for Disease Control
- tobacco use causes more than 5 million deaths per year and contributes to the development of serious illnesses such as cancer, diabetes, heart disease, lung disease (bronchitis, chronic airway destruction, emphysema), and stroke.
- CDC United States Center for Disease Control
- tobacco sales remains a multibillion dollar industry, generating an estimated $35 billion dollars per year in profits.
- Tobacco initially causes physical and mood-altering effects that are temporarily pleasing. Further, it is difficult for a person to stop using a tobacco product because tobacco contains nicotine. Nicotine is highly addictive, and not having the nicotine causes harsh withdrawal symptoms. It is very difficult for a person to overcome a nicotine addiction and stop smoking.
- Medicinal drugs can be taken by tobacco users to help them overcome their nicotine addiction. Some products to help a person stop smoking contain small amounts of nicotine as a medicinal drug to minimize withdrawal symptoms and gradually wean a person from their nicotine addiction. Medicinal smoking cessation drugs such as nicotine have to be taken over an extended period of time (often over the course of many months) to give the body time to adjust to having less nicotine. Medicinal drugs, medical devices, and other products, including smoking cessation products, are regulated in the United States by the U.S. Food and Drug Administration (FDA). FDA approved products on the market to help a person quit smoking include various medicinal drugs that require a doctor’s prescription as well as over-the-counter products.
- FDA FDA approved products on the market to help a person quit smoking include various medicinal drugs that require a doctor’s prescription as well as over-the-counter products.
- a two-part bioactive agent delivery system includes a disposable part, a reusable part, and a solvent removal element.
- the disposable part includes an agent reservoir, a transdermal patch communicating with the agent reservoir and adapted to transdermally deliver the bioactive agent to a user.
- the transdermal patch has a bottom surface adapted to contact skin of the user, a top surface opposite the bottom surface, and a gas permeable membrane disposed over the top surface of the transdermal patch.
- the reusable part includes a power source and control electronics that are adapted to deliver bioactive agent dissolved in a solvent from the agent reservoir to the transdermal patch.
- the solvent removal element includes a gap disposed between the disposable part and the reusable part to create a flow path for gaseous solvent to flow from the gas permeable membrane to ambient air around the bioactive agent delivery system.
- the gap can extend between parallel features on the disposable part and the reusable part.
- the gap can be formed when the disposable part and the reusable part are releasably engaged.
- the gap can be maintained with a spacer disposed between the disposable part and the reusable part.
- the spacer can extend from the disposable part.
- the spacer can extend from the reusable part.
- the system can further include at least one drainage port formed in an exterior surface of the reusable part or the disposable part.
- the disposable part can further include an agent outlet communicating with the agent reservoir and the transdermal patch.
- the agent outlet can be configured to provide the bioactive agent dissolved in the solvent to a space between the transdermal patch and the vapor permeable membrane.
- the agent reservoir can include a piston movably disposed in a chamber.
- the system can further include a spring extending between the agent reservoir piston and a surface to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent solution.
- the system can further include a bolus chamber communicating with the agent reservoir and an agent outlet, and the bolus chamber can include a piston movably disposed in a chamber. The volume of the bolus chamber can be less than the volume of the agent reservoir.
- the system can further include a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the agent outlet.
- the reusable part can include a valve driver, and the control electronics can be adapted to control the valve driver to actuate the valve to deliver bioactive agent solution from the agent reservoir to the bolus chamber and from the bolus chamber to the agent outlet.
- the system can further include a spring extending between the bolus chamber piston and a surface to pressurize the bolus chamber when the spring is compressed and the bolus chamber contains a quantity of bioactive agent solution.
- the system can further include a latch adapted to removably attach the disposable part to the reusable part. The latch can be positioned on one side of the system and a rail can be positioned along a second side of the system.
- the disposable part and the reusable part can be configured to slide relative to one another along the rail until the latch is activated to attach the disposable part to the reusable part.
- the system can further include a connection detector adapted to detect a connection between the disposable part and the reusable part.
- the connection detector can include a magnet.
- the magnet can be disposed in the disposable part.
- the magnet can be disposed in the reusable part.
- the connection detector further can include a magnetoresistive switch.
- a method of delivering bioactive agent includes: connecting a reusable part of a delivery system to a disposable part of the delivery system to form a flow path between the reusable part and the disposable part, delivering the bioactive agent dissolved in a solvent from a reservoir of the disposable part to a transdermal membrane of the disposable part, and allowing the solvent to evaporate and flow from the transdermal membrane through a gas permeable membrane and along the flow path to ambient air around the delivery system.
- the method can further include applying the transdermal membrane to skin of a user.
- the method can further include delivering the bioactive agent to the skin.
- the delivering step can include controlling with the reusable part movement of the bioactive agent dissolved in the solvent from the reservoir to the transdermal membrane.
- the controlling step can include actuating a valve.
- the method can further include detecting a connection between the disposable part and the reusable part.
- the detecting step can include sensing a magnetic field.
- Figure 1 is a perspective view of a two-part bioactive agent delivery system according to an embodiment.
- Figure 2 is a perspective view of a partially connected two-part bioactive agent delivery system according to an embodiment.
- Figure 3 is a perspective view of a portion of the disposable part of the two-part bioactive agent delivery system of Figure 1 or Figure 2.
- Figure 4 is an exploded view of the disposable part of the two-part bioactive agent delivery system of Figure 1 or Figure 2.
- Figure 5 is a side view of a chassis of the disposable part of the two-part bioactive agent delivery system of Figure 1 or Figure 2.
- Figure 6 is a side view of the two-part bioactive agent delivery system of Figure 1 or Figure 2.
- Figure 7 is an exploded view of the reusable part of the two-part bioactive agent delivery system of Figure 1 or Figure 2.
- Figure 8 shows a connection sensor for a two-part bioactive agent delivery system according to an embodiment.
- Figure 9 is a perspective view of a partially connected two-part bioactive agent delivery system according to an embodiment.
- Figure 10 is a perspective view of the two-part bioactive agent delivery system of Figure 9.
- Figure 11 is a top view of the disposable part of the two-part bioactive agent delivery system of Figure 9.
- Figure 12 is a top view of the reusable part of the two-part bioactive agent delivery system of Figure 9.
- Figure 13 is a top view of the two-part bioactive agent delivery system of Figure 9.
- Figures 14-16 are additional perspective views of the partially connected two-part bioactive agent delivery system of Figure 9.
- Figure 17 is another perspective view of the two-part bioactive agent delivery system of Figure 9.
- FIG. 18 is a top view of the chassis of the two-part bioactive agent delivery system of Figure 9.
- Figures 19A-19C are side view of the two-part bioactive agent delivery system of Figure 9.
- Figures 20A-20C are perspective views of the disposable part of the two-part bioactive agent delivery system of Figure 9.
- Figure 21A is another perspective view of the disposable part of the two-part bioactive delivery system of Figure 9.
- Figure 21B is an exploded view of the disposable part of Figure 21A.
- Figure 21C is an exploded view of the fluidics assembly of Figures 21 A and 21B.
- Figure 22 is an exploded view of the reusable part of the two-part bioactive agent delivery system of Figure 9.
- the systems can include two parts: a disposable part and a reusable part.
- the disposable part may include bioactive agent and system parts that come into contact with bioactive agent, and the reusable part may not contain bioactive agent and system parts that come into contact with bioactive agent.
- the disposable part can include an agent reservoir, a bolus chamber, a valve alternately communicating the reservoir with the bolus chamber and the bolus chamber with an outlet, a solvent removal element, and a transdermal membrane receiving the agent from the outlet.
- the reusable part can include a valve driver and control electronics.
- bioactive agent delivery systems described herein can deliver a solution of the bioactive agent to a transdermal patch.
- Solvent from the bioactive agent solution can evaporate from the transdermal patch through the solvent removal element (e.g., a gap between the reusable part and the disposable part) to control the manner in which the bioactive agent passes from the patch into the user’s skin.
- a bioactive agent delivery system as described herein may be useful for delivering a bioactive agent to any part on or in a user’s body.
- a bioactive agent delivery system as described herein may be especially useful for delivering a bioactive agent topically or transdermally to or through a user’s skin to a skin layer or bloodstream.
- Effective topical or transdermally delivery may be aided by use of a skin delivery membrane such as described herein for transferring active agent across the skin that is fully or sufficiently wetted to effectively transfer a dose of bioactive agent to a user’s skin.
- a bioactive agent delivery system may be electronically controlled, programmable, portable, and/or wearable.
- the bioactive agent delivery systems described herein may reproducibly deliver a fixed amount of a bioactive agent to a user, such as to a user’s skin, to have a therapeutic or prophylactic effect on the user.
- the bioactive agent delivery systems may be configured to be wearable and to deliver a fixed amount of a bioactive agent to a user’s skin in a relatively thin, quiet, easy to use, convenient, electronically controlled system.
- the bioactive agent delivery systems may be configured to be attached to a user’s body (such as for a day or shorter or longer), connect with a user’s skin, and deliver a bioactive agent across the user’s skin.
- the bioactive agent delivery systems as described herein may be useful for delivering a bioactive agent to a user for addiction or dependency management or prevention such as for a drug addiction, for diabetes or other disease management or prevention, for pain management or prevention, or for another therapeutic or prophylactic purpose.
- the systems, devices, and methods may be especially useful for delivering multiple doses of a drug or other bioactive agent to a user over time with a safe, inexpensive, convenient, and easy-to-use system that minimizes risk of a drug or other bioactive agent overdose.
- a bioactive agent delivery system as described herein may be configured to deliver multiple doses or boluses during the course of a day and/or for multiple days. Delivering multiple boluses may be especially useful to help a user control cravings or other withdrawal symptoms by delivering a bioactive agent dose (e.g., a dose of nicotine) especially during (or before) a time of day when cravings or withdrawal symptoms are normally most troublesome (such as delivering a dose during the night to prevent cravings upon waking).
- a bioactive agent dose e.g., a dose of nicotine
- having a bioactive agent delivery system with a disposable part may allow the system to be relatively small or flat and easy to wear.
- a system may be relatively small or flat because the disposable part needs only contain a limited amount of bioactive agent and/or the reusable part needs only be imparted with sufficient force or power for a limited number of dose deliveries before being recharged.
- a bioactive delivery system as described herein may be less than about 20 mm, less than about 16 mm, less than about 15 mm, less than about 14 mm, less than about 13 mm, less than about 12 mm, less than about 11 mm or less than about lOmm in thickness and may be less than 40 mm, less than 35 mm in length or width, or less than 30 mm in length or width.
- a system may have less than 1500 mm 2 or less than 1000 mm 2 top (or bottom) surface area. “Bottom” in this context generally refers the part(s) of the system closest to a user.
- bottom may refer to the transdermal patch and to the skin delivery member of a transdermal patch.
- a surface area of one side of a skin delivery member may be at least 100 mm2, at least 500 mm2, at least 1500 mm2, at least 2000 mm2, at least 2500 mm2 at least 3000 mm2 or less than or between any of these numbers (such as at least 500 mm2 and less than 2000 mm2).
- FIGS 1 and 2 show a two-part bioactive agent delivery system according to an embodiment of this invention.
- the system 10 has a reusable part 12 connectable to a disposable part 14.
- An adhesive element 16 (such as, e.g., adhesive foam) extends around the periphery of the disposable part 14, and a removable release liner 18 covers the adhesive surface of the adhesive element 16.
- the disposable part 14 also has a reservoir 20 containing a solution of the bioactive agent (e.g., nicotine) to be delivered transdermally to user.
- the reusable part 12 has control electronics, a user interface button 72, and an LED mode status indicator 24.
- One or more latches 22 may be used to connect and disconnect the disposable part 14 from the reusable part 12.
- An outer surface of the bioactive agent delivery system 10 when the reusable part 12 and the disposable part 14 are connected together may have any shape, such as circular, ovoid, rectangular, square, and may be contoured (or able to be contoured) to better fit a user’s skin
- FIG. 3-5 Further details of the disposable part 14 are shown in Figures 3-5.
- Mounted on a chassis 26 are the reservoir 20, a bolus chamber 28, and a valve chamber 30.
- a manifold communicates the reservoir 20 with the valve chamber 30 and the valve chamber 30 with the bolus chamber 28.
- Movable pistons 32 and 34 are disposed in the reservoir 20 and bolus chamber 28, respectively.
- a rotatable valve element 36 is disposed in valve chamber 30.
- a gas permeable membrane 38 formed, e.g., from Poreflon® polytetrafluoroethylene
- a transdermal drug delivery patch 40 e.g., a Celgard® membrane
- An upper housing 42 supports latch(es) 22 and partially covers reservoir 20, valve chamber 30, bolus chamber 28, and chassis 26.
- An opening 44 in housing 42 leads to a fill port 46 that can be used to add a solution of the bioactive agent to reservoir 20 and bolus chamber 28.
- a fill port plug 48 seals fill port 46 after filling the reservoir and bolus chamber with a solution of the bioactive agent.
- Chassis 26 has supports 53, 54, and 59 engaging the reservoir 20, valve chamber 30, and bolus chamber 28, respectively, to hold the reservoir 20, valve chamber 30, and bolus chamber 28 in place.
- One or more raised spacers 60 extend upwardly from the top side of chassis 26. Open vents 62 in chassis 26 are disposed over the gas permeable membrane 38. Spacers 60 engage the underside of the reusable part 12 to establish a gap 64 forming a flow path for evaporated solvent passing from transdermal patch 40 through gas permeable membrane 38 and chassis vents 62, as described below.
- the one or more spacers 60 may extend from the reusable part instead of, or in addition to, the spacer(s) extending from the disposable part.
- Ramped ledges 99 can transition the chassis from a thinner section 56 to a thicker section 58.
- Figure 7 shows components of the reusable part 12.
- a latch element 86 adapted to engage with the latch 22 of the disposable part is formed in an upper housing 70.
- Disposed between an upper housing 70 and a lower housing 74 are a spring assembly 76 for the reservoir 20 and a spring assembly 78 for the bolus chamber 28.
- the spring assemblies 76 and 78 engage with the pistons 32 and 34, respectively, and the springs of the spring assemblies 76, 78 compress to pressurize the bioactive agent solution in reservoir 20 and bolus chamber 28, respectively.
- a motor assembly 80 engages valve element 36 and operates under the control of a microprocessor on the printed circuit board 82 using power from battery 84 to turn valve element 36 between a position in which reservoir 20 communicates with bolus chamber 28 and a position in which bolus chamber 28 communicates with patch 40.
- a control button 72 in the upper housing 70 communicates with the microprocessor. The control button 72 can further serve as a user input mechanism. It may be depressed, e.g., to power on the electronics; to pair the device with a smartphone application; to provide information about the user, such as the experience of a craving for a cigarette; or to request a device status update or other information.
- Status indicator 24 can indicate the status of the system, e.g., whether the system is delivering fluid, in stand-by mode, or empty of bioactive agent.
- the system 10 may be used to deliver a bioactive agent transdermally to a user.
- Disposable part 14 may be prefilled with a solution of the bioactive agent.
- the disposable part 14 may be connected to the reusable part 12 and latched with latch components 22 and 86. This connection compresses spring assemblies 76 and 78 against pistons 32 and 34 of reservoir 20 and bolus chamber 28, respectively, to pressurize the bioactive agent solution in the reservoir 20 and bolus chamber 28.
- Release liner 18 may be removed so that the adhesive on the underside of adhesive element 16 can be attached to the user’s skin.
- motor assembly 80 turns rotatable valve element 36 to a position in which the contents of bolus chamber 28 are delivered through an agent outlet in chassis 26 to a space between gas permeable membrane 38 and transdermal patch 40.
- solvent from the bioactive agent solution evaporates and passes through gas permeable membrane 38 and the vents 62 in chassis 26 to reach the flow path defined by gap 64. Removal of solvent from the transdermal patch 40 enables the percentage of bioactive agent in liquid solution in the patch to remain high enough to maintain a desired transdermal delivery rate of the bioactive agent until essentially all of the bioactive agent in the bolus of bioactive agent solution has been delivered. Subsequent boluses of bioactive agent may be delivered by actuating the valve element 36 to enable refilling of the bolus chamber 28 with solution from the reservoir 20 followed by movement of the valve element 36 to permit delivery of the next bolus from bolus chamber 28 to the transdermal patch 40. The timing of the bolus deliveries are under the control of the programmed microprocessor.
- the systems described herein can include a sensor to detect connection of a disposable part with the reusable part.
- a system 210 includes a magnetoresistive switch 290 disposed in the reusable part 212 that detects a magnet 292 disposed in the spring assembly 278.
- the magnet can be disposed in the disposable part 214 (see, for example, magnet 392 in Figure 21B).
- Use of the magnetoresistive switch 290 enables the electronics to be encapsulated and waterproof.
- a reed switch or a Hall sensor may be used as an alternative to the magnetoresistive switch.
- Information about the connection times and durations of the reusable part with the disposable part may be used, e.g., to monitor compliance with a drug delivery regimen.
- system 310 includes a reusable part 312 connectable to a disposable part 314, an adhesive element 316, and release liner 318.
- the reusable part 312 has control electronics, a user interface button 372, and an LED mode status indicator 324.
- the upper housing 342 of the disposable part 314 and the housing 370 of the reusable part abut one another to create a substantially smooth outer contour.
- the system 310 further includes a single latch 322 and rail 333 to connect and disconnect the disposable part 314 from the reusable part 312.
- the latch 322 can be on a first side of the disposable part 314 while the rail 333 can be positioned on a second opposite side of the disposable part 314.
- the rail 333 can extend substantially parallel with the longitudinal axis of the system 310.
- the rail 333 can be configured to mate with a sliding element 335 (e.g., a c-shaped element) on the housing 730 of the reusable part 312. In use, the sliding element 335 can slide along the rail 333 as the disposable part 314 and reusable part 312 are engaged.
- a sliding element 335 e.g., a c-shaped element
- the rail 333 can thus advantageously ensure that the disposable part 314 and reusable part 312 remain aligned as they are connected or disconnected.
- the latch 322 can have a cantilevered first end 361 and a sloped or ramped second end 366 (see Figure 11).
- the ramped second end 366 can be connected to the upper housing 342 of the disposable part 314 while the cantilevered first end 361 can be configured to mate with a latch element 386 (e.g., an opening) on the housing 370 of the reusable part 312.
- the latch 322 and latch element 386 can function to hold the disposable part 314 and reusable part 312 together until the latch 322 is depressed by the user.
- the system 310 can include open vents 362 through the chassis 326 so as to expose the membrane 338 thereunder.
- the vents 362 can be positioned in a central portion of the chassis 326 and can be cut so as to maximize the exposure of the surface of the membrane 338.
- the vents 362 can expose 5-30% of the surface of the membrane 338, such as 10-20% of the surface.
- Diagonal struts 375 can extend between the vents 362 to maintain the strength of the chassis 362.
- the vents 326 can connect to gap 364 between the reusable part 312 and the disposable part 314.
- the gap 364 can be formed between the parallel bottom surface 381 of the reusable part 312 and top surface 383 of the disposable part 314.
- the gap 364 can be formed by the framework of the system, including the mating between the rail 333 and sliding element 335 and the mating between the latch 322 and latch element 382. Additionally, one or more spacers 360 can be configured to help maintain the gap 364.
- the spacers 360 can be, for example, cylindrical or semi-spherical elements that protrude upwards (i.e., from the top surface 383 of) the chassis 326. Further, the spacers 360 can be positioned on a side of the chassis 360 that is opposite to the reservoir 320, bolus chamber 320, and valve chamber 330 (e.g., on the thinner section 356).
- Each of the spacers 360 can have a small diameter (e.g., a diameter that is less than 10% of the width of the chassis 26).
- ramped ledges 399 can transition between the thinner section 356 of the chassis 326 and the thicker section 358 of the chassis 326.
- the spacers 360 can engage the bottom surface 381 of the reusable part 312 to maintain the gap 364 and therefore to form a flow path for evaporated solvent passing through the vents 362.
- the one or more spacers may extend from the reusable part instead of, or in addition to, the spacers extending from the disposable part.
- the thick section 358 of the chassis 326 can engage the bottom surface 381 of the reusable part 312 (i.e., can be coincident with the bottom of the reusable part 312), which can further maintain the gap 364 above the thin section 356.
- the system 310 can further include one or more drainage ports 371 therein that are aligned with or connected with the gap 364 and can provide drainage for any excess fluid left in the side of the system 310.
- the drainage ports 371 can be formed in the upper housing 377 of the disposable part 312 proximate to the thicker section 358 of the chassis 326 and can facilitate water drainage (e.g., from the user bathing and/or otherwise getting fluid in or on the system 310).
- the drainage ports 371 can be positioned such that, when the system is worn on the body (e.g., on the arm) and the device 310 is turned vertically, water will exit the device by gravity via ports 371.
- the ports 371 can be sized so as to avoid capillary pooling of water therein.
- the disposable part 314 can further include a transdermal delivery patch 340, a permeable membrane 338 and a foam adhesive 365 with deadening strips 364.
- the deadening strips 364 can provide the user with an edge or small flap to grab onto to help remove the system 310 from the skin.
- An opening 344 in housing 342 leads to a fill port 346 that can be used to add a solution of the bioactive agent to reservoir 320 and bolus chamber 328.
- Movable pistons 332 and 334 are disposed within the reservoir 320 and bolus chamber 328, respectively.
- the reusable part 312 can include a printed circuit board 382 positioned over the lower housing 374, bolus spring assembly 378 (to control piston 334), reservoir spring assembly 376 (to control piston 332).
- a motor 329 can control activation of the valve 336 and spring assemblies 376, 378.
- a power supply 384 e.g., batteries
- a detect magnet 392 can be positioned in the disposable part 314 while a magnetoresistive switch 390 can be positioned on the printed circuit board 382 of the reusable part 312 to detect attachment of the disposable part 314 to the reusable part 312 (i.e., when the magnet 392 and switch 390 are adjacent to one another upon attachment of the reusable part 312 and the disposable part 314).
- the system 310 can operate similar to system 10.
- the disposable part 314 may be connected to the reusable part 312 by sliding the rail 333 and sliding element 382 relative to one another until the components are latched with latch components 322 and 386. This connection compresses spring assemblies 376 and 378 against pistons 332 and 334 of reservoir 320 and bolus chamber 328, respectively, to pressurize the bioactive agent solution in the reservoir 320 and bolus chamber 328.
- motor assembly 380 turns rotatable valve element 336 to a position in which the contents of bolus chamber 328 are delivered to the patient’s skin through the transdermal delivery patch 340.
- a feature or element When a feature or element is herein referred to as being“on” another feature or element, it can be directly on the other feature or element or intervening features and/or elements may also be present. In contrast, when a feature or element is referred to as being“directly on” another feature or element, there are no intervening features or elements present. It will also be understood that, when a feature or element is referred to as being“connected”,“attached” or “coupled” to another feature or element, it can be directly connected, attached or coupled to the other feature or element or intervening features or elements may be present.
- references to a structure or feature that is disposed“adjacent” another feature may have portions that overlap or underlie the adjacent feature.
- Terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
- the singular forms“a”,“an” and“the” are intended to include the plural forms as well, unless the context clearly indicates otherwise.
- the terms“comprises” and/or “comprising,” when used in this specification, specify the presence of stated features, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, and/or groups thereof.
- the term“and/or” includes any and all combinations of one or more of the associated listed items and may be abbreviated as“/”.
- spatially relative terms such as“under”,“below”,“lower”,“over”,“upper” and the like, may be used herein for ease of description to describe one element or feature’s relationship to another element(s) or feature(s) as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if a device in the figures is inverted, elements described as“under” or“beneath” other elements or features would then be oriented“over” the other elements or features. Thus, the exemplary term“under” can encompass both an orientation of over and under.
- the device may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.
- the terms“upwardly”,“downwardly”,“vertical”,“horizontal” and the like are used herein for the purpose of explanation only unless specifically indicated otherwise.
- a numeric value may have a value that is +/- 0.1% of the stated value (or range of values), +/- 1% of the stated value (or range of values), +/- 2% of the stated value (or range of values), +/- 5% of the stated value (or range of values), +/- 10% of the stated value (or range of values), etc.
- Any numerical values given herein should also be understood to include about or approximately that value, unless the context indicates otherwise. For example, if the value“10” is disclosed, then“about 10” is also disclosed. Any numerical range recited herein is intended to include all sub-ranges subsumed therein.
- inventive subject matter may be referred to herein individually or collectively by the term“invention” merely for convenience and without intending to voluntarily limit the scope of this application to any single invention or inventive concept, if more than one is, in fact, disclosed.
- inventive concept any arrangement calculated to achieve the same purpose may be substituted for the specific embodiments shown.
- This disclosure is intended to cover any and all adaptations or variations of various embodiments. Combinations of the above embodiments, and other embodiments not specifically described herein, will be apparent to those of skill in the art upon reviewing the above description.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17/057,318 US11596779B2 (en) | 2018-05-29 | 2019-05-29 | Drug delivery methods and systems |
AU2019279884A AU2019279884A1 (en) | 2018-05-29 | 2019-05-29 | Drug delivery methods and systems |
JP2021517561A JP7420797B2 (en) | 2018-05-29 | 2019-05-29 | Drug delivery methods and systems |
CA3101966A CA3101966A1 (en) | 2018-05-29 | 2019-05-29 | Drug delivery methods and systems |
EP19812316.8A EP3801732A4 (en) | 2018-05-29 | 2019-05-29 | Drug delivery methods and systems |
US18/178,442 US12017029B2 (en) | 2023-03-03 | Drug delivery methods and systems |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862677494P | 2018-05-29 | 2018-05-29 | |
US62/677,494 | 2018-05-29 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US17/057,318 A-371-Of-International US11596779B2 (en) | 2018-05-29 | 2019-05-29 | Drug delivery methods and systems |
US18/178,442 Continuation US12017029B2 (en) | 2023-03-03 | Drug delivery methods and systems |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2019232077A1 true WO2019232077A1 (en) | 2019-12-05 |
Family
ID=68698437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2019/034432 WO2019232077A1 (en) | 2018-05-29 | 2019-05-29 | Drug delivery methods and systems |
Country Status (6)
Country | Link |
---|---|
US (1) | US11596779B2 (en) |
EP (1) | EP3801732A4 (en) |
JP (1) | JP7420797B2 (en) |
AU (1) | AU2019279884A1 (en) |
CA (1) | CA3101966A1 (en) |
WO (1) | WO2019232077A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023272784A1 (en) * | 2021-01-05 | 2023-01-05 | Medtrum Technologies Inc. | A skin patch drug infusion device |
US11596779B2 (en) | 2018-05-29 | 2023-03-07 | Morningside Venture Investments Limited | Drug delivery methods and systems |
US12017029B2 (en) | 2023-03-03 | 2024-06-25 | Morningside Venture Investments Limited | Drug delivery methods and systems |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5254616B2 (en) | 2004-09-13 | 2013-08-07 | クロノ セラピューティクス、インコーポレイテッド | Biosynchronous transdermal drug delivery |
EP3250258A4 (en) * | 2015-01-28 | 2018-09-05 | Chrono Therapeutics, Inc. | Drug delivery methods and systems |
US11724045B2 (en) * | 2019-08-21 | 2023-08-15 | Medtronic Minimed, Inc. | Connection of a stopper and piston in a fluid delivery device |
USD1010106S1 (en) * | 2021-09-27 | 2024-01-02 | Medtrum Technologies Inc. | Drug infusion device |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060271020A1 (en) * | 2005-05-24 | 2006-11-30 | Huang Joseph Z | Portable drug delivery device including a detachable and replaceble administration or dosing element |
US8252321B2 (en) * | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
US20160220798A1 (en) | 2015-01-28 | 2016-08-04 | Zita S. Netzel | Drug delivery methods and systems |
US20160271020A1 (en) | 2015-03-19 | 2016-09-22 | Harry Coffey | Pacifier Holder |
US20170157322A1 (en) * | 2009-12-30 | 2017-06-08 | Medtronic Minimed, Inc. | Connection and alignment detection systems and methods |
US9687186B2 (en) * | 2005-07-21 | 2017-06-27 | Steadymed Ltd. | Drug delivery device |
WO2018148746A1 (en) * | 2017-02-13 | 2018-08-16 | Chrono Therapuetics Inc. | Transdermal drug delivery devices and methods |
Family Cites Families (580)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2183482A (en) | 1936-12-23 | 1939-12-12 | Schmid Inc Julius | Injector |
US3279653A (en) | 1964-12-17 | 1966-10-18 | Frederick W Pfleger | Escapement controlled dispensing apparatus |
US3845217A (en) | 1972-11-16 | 1974-10-29 | Helsingborg L Ab | Buffered smoking substitute compositions |
GB1528391A (en) | 1976-01-05 | 1978-10-11 | Gildemeister V | Aerosol compositions |
GB2030862A (en) | 1978-04-10 | 1980-04-16 | Smith A | A composition for treating drug addiction such as smoking nicotine-containing products |
US4321387A (en) | 1980-03-21 | 1982-03-23 | Philip Morris, Incorporated | Process for the preparation of optically active nicotine analogs |
US4313439A (en) | 1980-03-24 | 1982-02-02 | Biotek, Inc. | Automated, spring-powered medicament infusion system |
US4327725A (en) | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
US4590278A (en) | 1981-01-29 | 1986-05-20 | Philip Morris Incorporated | Nicotine analogs |
US4332945A (en) | 1981-01-29 | 1982-06-01 | Philip Morris, Incorporated | Optically active nicotine analogs and process for their preparation |
US4379454A (en) | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
LU84485A1 (en) | 1982-11-22 | 1984-06-13 | Oreal | NOVEL ANTI-ACNE COMPOSITION BASED ON BENZOYL PEROXIDE AND AT LEAST ONE OTHER ACTIVE INGREDIENT |
GB8301659D0 (en) | 1983-01-21 | 1983-02-23 | Leo Ab | Smoking substitutes |
US4856188A (en) | 1984-10-12 | 1989-08-15 | Drug Delivery Systems Inc. | Method for making disposable and/or replenishable transdermal drug applicators |
GB8317576D0 (en) | 1983-06-29 | 1983-08-03 | Shaw A S W | Consumer tobacco products |
GB2142822B (en) | 1983-06-29 | 1987-02-11 | Alec Stanley Walter Shaw | Nicotine lozenges |
US4708716A (en) | 1983-08-18 | 1987-11-24 | Drug Delivery Systems Inc. | Transdermal drug applicator |
US5865786A (en) | 1983-08-18 | 1999-02-02 | Drug Delivery Systems, Inc. | Programmable control and mounting system for transdermal drug applicator |
BE899037A (en) | 1984-02-29 | 1984-06-18 | Trenker Ady | Nicotine compsn. to help people to stop smoking - is a tablet for sucking, which contains nicotine or its water-soluble acid salt |
US4597961A (en) | 1985-01-23 | 1986-07-01 | Etscorn Frank T | Transcutaneous application of nicotine |
US4953572A (en) | 1985-04-25 | 1990-09-04 | Rose Jed E | Method and apparatus for aiding in the reduction of incidence of tobacco smoking |
US4920989A (en) | 1985-04-25 | 1990-05-01 | Regents Of The University Of California | Method and apparatus for aiding in the reduction of incidence of tobacco smoking |
DE3586595T2 (en) | 1985-06-10 | 1993-04-08 | Drug Delivery Systems Inc | PROGRAMMABLE CONTROL AND BUILDING SYSTEM OF AN ADMINISTRATOR FOR TRANSDERMIC MEDICINES. |
US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
US4853854A (en) | 1985-12-26 | 1989-08-01 | Health Innovations, Inc. | Human behavior modification which establishes and generates a user adaptive withdrawal schedule |
US4772263A (en) | 1986-02-03 | 1988-09-20 | Regents Of The University Of Minnesota | Spring driven infusion pump |
DE3639418A1 (en) | 1986-11-18 | 1988-06-09 | Forschungsgesellschaft Rauchen | NICOTINE-BASED AGENT |
US4917676A (en) | 1986-11-20 | 1990-04-17 | Ciba-Geigy Corporation | User-activated transdermal therapeutic system |
AT391998B (en) | 1987-02-02 | 1990-12-27 | Falko Dr Skrabal | Device for determining the concentration of at least one medicinal substance in living organisms |
US5049387A (en) | 1987-03-09 | 1991-09-17 | Alza Corporation | Inducing skin tolerance to a sensitizing drug |
US5000956A (en) | 1987-03-09 | 1991-03-19 | Alza Corporation | Prevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug |
US5013293A (en) | 1987-05-28 | 1991-05-07 | Drug Delivery Systems Inc. | Pulsating transdermal drug delivery system |
US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
US5388571A (en) | 1987-07-17 | 1995-02-14 | Roberts; Josephine A. | Positive-pressure ventilator system with controlled access for nebulizer component servicing |
US5073380A (en) | 1987-07-27 | 1991-12-17 | Mcneil-Ppc, Inc. | Oral sustained release pharmaceutical formulation and process |
ATE122353T1 (en) | 1987-10-05 | 1995-05-15 | Yamanouchi Pharma Co Ltd | HETEROCYCLIC SPIR COMPOUNDS AND THEIR PRODUCTION. |
JPH01265021A (en) | 1987-10-29 | 1989-10-23 | Hercon Lab Corp | Article for discharging and supplying composition containing pharmacologically active substance to animal tissue in controllable manner |
US4917895A (en) | 1987-11-02 | 1990-04-17 | Alza Corporation | Transdermal drug delivery device |
US4885154A (en) | 1988-03-01 | 1989-12-05 | Alza Corporation | Method for reducing sensitization or irritation in transdermal drug delivery and means therefor |
US5472946A (en) | 1988-04-08 | 1995-12-05 | Peck; James V. | Transdermal penetration enhancers |
US5364630A (en) | 1988-06-14 | 1994-11-15 | Alza Corporation | Subsaturated nicotine transdermal therapeutic system |
US5028428A (en) | 1988-08-09 | 1991-07-02 | Estee Lauder Inc. | Anti-irritant and desensitizing compositions and methods of their use |
US4952928A (en) | 1988-08-29 | 1990-08-28 | B. I. Incorporated | Adaptable electronic monitoring and identification system |
US5496266A (en) | 1990-04-30 | 1996-03-05 | Alza Corporation | Device and method of iontophoretic drug delivery |
US5236714A (en) | 1988-11-01 | 1993-08-17 | Alza Corporation | Abusable substance dosage form having reduced abuse potential |
US5248501A (en) | 1988-11-22 | 1993-09-28 | Parnell Pharmaceuticals | Drug delivery systems containing eriodictyon fluid extract as an excipient, and methods and compositions associated therewith |
IE62662B1 (en) | 1989-01-06 | 1995-02-22 | Elan Corp Plc | Use of nicotine in the treatment of conditions susceptible to said treatment |
JP2638635B2 (en) | 1989-01-31 | 1997-08-06 | 積水化学工業株式会社 | Transdermal formulation |
US4908213A (en) | 1989-02-21 | 1990-03-13 | Schering Corporation | Transdermal delivery of nicotine |
GB2230439A (en) | 1989-04-20 | 1990-10-24 | Alec Stanley Walter Shaw | Nicotine lozenges |
US5262165A (en) | 1992-02-04 | 1993-11-16 | Schering Corporation | Transdermal nitroglycerin patch with penetration enhancers |
US5525351A (en) | 1989-11-07 | 1996-06-11 | Dam; Anders | Nicotine containing stimulant unit |
US5512306A (en) | 1992-06-19 | 1996-04-30 | Pharmica Ab | Smoking substitute |
US5149719A (en) | 1990-04-27 | 1992-09-22 | Minnesota Mining And Manufacturing Company | Composition for transdermal penetration of medicaments |
US5130139A (en) | 1990-07-06 | 1992-07-14 | Alza Corporation | Reduction or prevention of skin irritation by drugs |
US5120545A (en) | 1990-08-03 | 1992-06-09 | Alza Corporation | Reduction or prevention of sensitization to drugs |
US5242941A (en) | 1990-12-04 | 1993-09-07 | State Of Oregon | Methods of treating circadian rhythm disorders |
US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
US5232704A (en) | 1990-12-19 | 1993-08-03 | G. D. Searle & Co. | Sustained release, bilayer buoyant dosage form |
US5221254A (en) | 1991-04-02 | 1993-06-22 | Alza Corporation | Method for reducing sensation in iontophoretic drug delivery |
ES2153360T3 (en) | 1991-05-29 | 2001-03-01 | Abbott Lab | ISOXAZOL AND ISOTIAZOL COMPOUNDS THAT IMPROVE REASONING FUNCTIONS. |
US5149538A (en) | 1991-06-14 | 1992-09-22 | Warner-Lambert Company | Misuse-resistive transdermal opioid dosage form |
US5464387A (en) | 1991-07-24 | 1995-11-07 | Alza Corporation | Transdermal delivery device |
US5273755A (en) | 1991-08-23 | 1993-12-28 | Cygnus Therapeutic Systems | Transdermal drug delivery device using a polymer-filled microporous membrane to achieve delayed onset |
US5273756A (en) | 1991-08-23 | 1993-12-28 | Cygnus Therapeutic Systems | Transdermal drug delivery device using a membrane-protected microporous membrane to achieve delayed onset |
US5352456A (en) | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
US5304739A (en) | 1991-12-19 | 1994-04-19 | Klug Reja B | High energy coaxial cable for use in pulsed high energy systems |
GB9200047D0 (en) | 1992-01-03 | 1992-02-26 | Univ Alberta | Nicotine-containing nasal spray |
US6436078B1 (en) | 1994-12-06 | 2002-08-20 | Pal Svedman | Transdermal perfusion of fluids |
CA2128429A1 (en) | 1992-01-21 | 1993-07-22 | Howard Alliger | Method of treating small mouth ulcers |
IL104365A0 (en) | 1992-01-31 | 1993-05-13 | Gensia Pharma | Method and apparatus for closed loop drug delivery |
CH686816A5 (en) | 1992-02-04 | 1996-07-15 | Asulab Ag | Means for delivering a drug. |
US5212188A (en) | 1992-03-02 | 1993-05-18 | R. J. Reynolds Tabacco Company | Method for treatment of neurodegenerative diseases |
US5242934A (en) | 1992-03-02 | 1993-09-07 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
US5242935A (en) | 1992-03-06 | 1993-09-07 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
US5405614A (en) | 1992-04-08 | 1995-04-11 | International Medical Associates, Inc. | Electronic transdermal drug delivery system |
US5756117A (en) | 1992-04-08 | 1998-05-26 | International Medical Asscociates, Inc. | Multidose transdermal drug delivery system |
US5227391A (en) | 1992-04-10 | 1993-07-13 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
US5232933A (en) | 1992-05-21 | 1993-08-03 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
US5310404A (en) | 1992-06-01 | 1994-05-10 | Alza Corporation | Iontophoretic delivery device and method of hydrating same |
US5501697A (en) | 1992-06-23 | 1996-03-26 | Fisher; Gary R. | Treatment device to aid in long-term cessation of smoking |
CA2072040C (en) | 1992-06-23 | 2002-06-11 | Charles Borg | Method and device to facilitate the cognitive development of alternative response behaviour |
US5248690A (en) | 1992-07-07 | 1993-09-28 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
US5252604A (en) | 1992-07-10 | 1993-10-12 | Hoffmann-La Roche Inc. | Compositions of retinoic acids and tocopherol for prevention of dermatitis |
WO1994004109A1 (en) | 1992-08-25 | 1994-03-03 | Cygnus Therapeutic Systems | Printed transdermal drug delivery device |
IL107184A (en) | 1992-10-09 | 1997-08-14 | Abbott Lab | Heterocyclic ether compounds that enhance cognitive function |
WO1994010987A1 (en) | 1992-11-09 | 1994-05-26 | Pharmetrix Corporation | Combined analgesic delivery methods for pain management |
CA2114968A1 (en) | 1993-02-25 | 1994-08-26 | John Wille | Transdermal treatment with mast cell degranulating agents for drug-induced hypersensitivity |
US5843979A (en) | 1993-02-25 | 1998-12-01 | Bristol-Myers Squibb Company | Transdermal treatment with mast cell degranulating agents for drug-induced hypersensitivity |
US5516793A (en) | 1993-04-26 | 1996-05-14 | Avon Products, Inc. | Use of ascorbic acid to reduce irritation of topically applied active ingredients |
US5445609A (en) | 1993-05-28 | 1995-08-29 | Alza Corporation | Electrotransport agent delivery device having a disposable component and a removable liner |
US5451407A (en) | 1993-06-21 | 1995-09-19 | Alza Corporation | Reduction or prevention of skin irritation or sensitization during transdermal administration of a irritating or sensitizing drug |
EP0716589A4 (en) | 1993-07-23 | 1997-06-11 | Morris Herstein | Cosmetic, skin-renewal stimulating composition with long-term irritation control |
US5549906A (en) | 1993-07-26 | 1996-08-27 | Pharmacia Ab | Nicotine lozenge and therapeutic method for smoking cessation |
US5377258A (en) | 1993-08-30 | 1994-12-27 | National Medical Research Council | Method and apparatus for an automated and interactive behavioral guidance system |
US5533971A (en) | 1993-09-03 | 1996-07-09 | Alza Corporation | Reduction of skin irritation during electrotransport |
US5415629A (en) | 1993-09-15 | 1995-05-16 | Henley; Julian L. | Programmable apparatus for the transdermal delivery of drugs and method |
AU662877B3 (en) | 1993-10-21 | 1995-09-14 | Amal Hakim Khalil | Nicotine lozenges |
US5997501A (en) | 1993-11-18 | 1999-12-07 | Elan Corporation, Plc | Intradermal drug delivery device |
DE4400770C1 (en) | 1994-01-13 | 1995-02-02 | Lohmann Therapie Syst Lts | Plaster containing an active substance for delivery of oestradiol with at least one penetration enhancer, method of producing it and its use |
US5393526A (en) | 1994-02-07 | 1995-02-28 | Elizabeth Arden Company, Division Of Conopco, Inc. | Cosmetic compositions |
WO1995028144A1 (en) | 1994-04-13 | 1995-10-26 | Ciba-Geigy Ag | Temporally controlled drug delivery systems |
US6121276A (en) | 1994-04-22 | 2000-09-19 | Pentech Pharmaceuticals, Inc. | Apomorphine-containing dosage forms for ameliorating male erectile dysfunction |
US5876368A (en) | 1994-09-30 | 1999-03-02 | Becton Dickinson And Company | Iontophoretic drug delivery device having improved controller |
US5445823A (en) | 1994-10-20 | 1995-08-29 | The Procter & Gamble Company | Dermatological compositions and method of treatment of skin lesions therewith |
US5505958A (en) | 1994-10-31 | 1996-04-09 | Algos Pharmaceutical Corporation | Transdermal drug delivery device and method for its manufacture |
US5703100A (en) | 1994-11-10 | 1997-12-30 | Sibia Neurosciences, Inc. | Modulators of acetylcholine receptors |
US5686100A (en) | 1994-11-22 | 1997-11-11 | E.R. Squibb & Sons, Inc. | Prophylactic and therapeutic treatment of skin sensitization and irritation |
US5618557A (en) | 1994-11-22 | 1997-04-08 | E.R. Squibb & Sons, Inc. | Prophylactic treatment of allergic contact dermatitis |
US5697896A (en) | 1994-12-08 | 1997-12-16 | Alza Corporation | Electrotransport delivery device |
DE4444238A1 (en) | 1994-12-13 | 1996-06-20 | Beiersdorf Ag | Cosmetic or dermatological drug combinations of cinnamic acid derivatives and flavone glycosides |
FR2728793A1 (en) | 1994-12-28 | 1996-07-05 | Oreal | Compsns. for treating sensitive skin |
US5562607A (en) | 1995-01-18 | 1996-10-08 | Alza Corporation | Electrotransport device having reusable controller power saver |
US5879322A (en) | 1995-03-24 | 1999-03-09 | Alza Corporation | Self-contained transdermal drug delivery device |
AU5543196A (en) | 1995-04-12 | 1996-10-30 | Robert B. Hopp | Skin patch for use in contact immunotherapy |
US5601839A (en) | 1995-04-26 | 1997-02-11 | Theratech, Inc. | Triacetin as a penetration enhancer for transdermal delivery of a basic drug |
US5882676A (en) | 1995-05-26 | 1999-03-16 | Alza Corporation | Skin permeation enhancer compositions using acyl lactylates |
IL118279A (en) | 1995-06-07 | 2006-10-05 | Abbott Lab | 3 - pyridyloxy (or thio) alkyl heterocyclic compounds, pharmaceutical compositions containing them and their uses in the preparation of medicaments for controlling chemical synaptic transmission |
US6093419A (en) | 1995-06-07 | 2000-07-25 | Lectec Corporation | Compliance verification method and device in compulsory drug administration |
US6245347B1 (en) | 1995-07-28 | 2001-06-12 | Zars, Inc. | Methods and apparatus for improved administration of pharmaceutically active compounds |
EP0853621A1 (en) | 1995-09-22 | 1998-07-22 | Novo Nordisk A/S | Novel substituted azacyclic or azabicyclic compounds |
WO1997011073A1 (en) | 1995-09-22 | 1997-03-27 | Novo Nordisk A/S | Novel substituted azacyclic or azabicyclic compounds |
US5688232A (en) | 1995-09-28 | 1997-11-18 | Becton Dickinson And Company | Iontophoretic drug delivery device having an improved controller |
AU7119096A (en) | 1995-09-28 | 1997-04-17 | Becton Dickinson & Company | Iontophoretic drug delivery system, including reusable device |
EP0874818B1 (en) | 1995-11-17 | 2003-05-21 | MERCK & CO. INC. | Novel substituted aryl compounds useful as modulators of acetylcholine receptors |
US8092224B2 (en) | 1995-11-22 | 2012-01-10 | James A. Jorasch | Systems and methods for improved health care compliance |
WO1997018782A1 (en) | 1995-11-22 | 1997-05-29 | Bristol-Myers Squibb Company | Treatment with calcium channel blockers for drug-induced hypersensitivity |
US5858001A (en) | 1995-12-11 | 1999-01-12 | Elan Medical Technologies Limited | Cartridge-based drug delivery device |
US5846983A (en) | 1996-02-09 | 1998-12-08 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
WO1997034605A1 (en) | 1996-03-21 | 1997-09-25 | Mayo Foundation For Medical Education And Research | Use of nicotine to treat liver disease |
US6271240B1 (en) | 1996-05-06 | 2001-08-07 | David Lew Simon | Methods for improved regulation of endogenous dopamine in prolonged treatment of opioid addicted individuals |
US5785688A (en) | 1996-05-07 | 1998-07-28 | Ceramatec, Inc. | Fluid delivery apparatus and method |
ES2206709T3 (en) | 1996-05-13 | 2004-05-16 | Novartis Consumer Health S.A. | ORAL SUPPLY SYSTEM. |
US5716987A (en) | 1996-06-21 | 1998-02-10 | Bristol-Myers Squibb Company | Prophylactic and therapeutic treatment of skin sensitization and irritation |
GB9614902D0 (en) | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
US5788671A (en) | 1996-08-14 | 1998-08-04 | Sims Deltec, Inc. | Reusable cassette housings and methods |
EP0928155A1 (en) | 1996-08-16 | 1999-07-14 | Roche Diagnostics GmbH | Monitoring system for the regular intake of a medicament |
US5972389A (en) | 1996-09-19 | 1999-10-26 | Depomed, Inc. | Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter |
US5797867A (en) | 1996-09-27 | 1998-08-25 | Becton Dickinson And Company | Iontophoretic drug delivery system, including method for activating same for attachment to patient |
US5919156A (en) | 1996-09-27 | 1999-07-06 | Becton, Dickinson And Company | Iontophoretic drug delivery system, including unit for dispensing patches |
US6746688B1 (en) | 1996-10-13 | 2004-06-08 | Neuroderm Ltd. | Apparatus for the transdermal treatment of Parkinson's disease |
US5800832A (en) | 1996-10-18 | 1998-09-01 | Virotex Corporation | Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces |
CA2272326C (en) | 1996-11-21 | 2005-03-29 | Carole Rossi | Miniature valve for filling the reservoir of an apparatus for the transdermal administration of medicine |
DE19650115C1 (en) | 1996-12-03 | 1998-07-02 | Fraunhofer Ges Forschung | Medication dosing device |
US5908301A (en) | 1996-12-05 | 1999-06-01 | Lutz; Raymond | Method and device for modifying behavior |
US8734339B2 (en) | 1996-12-16 | 2014-05-27 | Ip Holdings, Inc. | Electronic skin patch for real time monitoring of cardiac activity and personal health management |
US6019997A (en) | 1997-01-09 | 2000-02-01 | Minnesota Mining And Manufacturing | Hydroalcoholic compositions for transdermal penetration of pharmaceutical agents |
US6018679A (en) | 1997-01-29 | 2000-01-25 | Novartis Finance Corp. | Iontophoretic transdermal delivery and control of adverse side-effects |
US6020335A (en) | 1997-02-06 | 2000-02-01 | Pfizer Inc | (N-(pyridinylmethyl)-heterocyclic)ylideneamine compounds as nicotinic acetylcholine receptor binding agents |
US5860957A (en) | 1997-02-07 | 1999-01-19 | Sarcos, Inc. | Multipathway electronically-controlled drug delivery system |
US5861423A (en) | 1997-02-21 | 1999-01-19 | Caldwell; William Scott | Pharmaceutical compositions incorporating aryl substituted olefinic amine compounds |
DE69826113T2 (en) | 1997-03-11 | 2005-01-20 | Arakis Ltd., Saffron Walden | R AND S-ENANTIOMER SEPARATED DOSAGE FORMS |
FR2761072B1 (en) | 1997-03-20 | 1999-04-23 | Synthelabo | 2,3-DIHYDROFURO [3,2-B] PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
US5977131A (en) | 1997-04-09 | 1999-11-02 | Pfizer Inc. | Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents |
WO1998046093A1 (en) | 1997-04-14 | 1998-10-22 | Robert Lindburg | Smoking control device |
US6024981A (en) | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
JP2002502383A (en) | 1997-05-30 | 2002-01-22 | ニューロサーアチ・アクティーゼルスカブ | 9-Azabicyclo (3.3.1) non-2-ene and nonane derivatives as cholinergic ligands at the nicotine ACh receptor |
EP0984965B1 (en) | 1997-05-30 | 2004-05-19 | Neurosearch A/S | 8-azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ach receptors |
CA2289576A1 (en) | 1997-05-30 | 1998-12-03 | Neurosearch A/S | Azacyclooctane and heptane derivatives, their preparation and use in therapy |
NZ500643A (en) | 1997-05-30 | 2001-12-21 | Neurosearch As | Spiro-quinuclidine derivatives and their use in treating conditions responsive to nicotinic ACh receptor modulators |
CA2290624C (en) | 1997-06-06 | 2006-12-05 | John W. Shell | Gastric-retentive oral drug dosage forms for controlled release of highly soluble drugs |
FR2765874B1 (en) | 1997-07-09 | 1999-08-13 | Synthelabo | 6-PYRROLIDIN-2-YLPYRINDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
AR013184A1 (en) | 1997-07-18 | 2000-12-13 | Astrazeneca Ab | SPYROZOBICYCLIC HETERO CYCLIC AMINES, PHARMACEUTICAL COMPOSITION, USE OF SUCH AMINES TO PREPARE MEDICINES AND METHOD OF TREATMENT OR PROPHYLAXIS |
US6420622B1 (en) | 1997-08-01 | 2002-07-16 | 3M Innovative Properties Company | Medical article having fluid control film |
US6034079A (en) | 1997-08-11 | 2000-03-07 | University Of South Florida | Nicotine antagonists for nicotine-responsive neuropsychiatric disorders |
ES2234139T3 (en) | 1997-08-11 | 2005-06-16 | Alza Corporation | DOSAGE FORM OF AN ACTIVE PROLONGED RELEASE AGENT ADAPTED FOR GASTRIC RETENTION. |
DE19738855C2 (en) | 1997-09-05 | 2001-01-04 | Lohmann Therapie Syst Lts | Transdermal therapeutic system with adhesive reservoir layer and unidirectional elastic back layer |
US6660295B2 (en) | 1997-09-30 | 2003-12-09 | Alza Corporation | Transdermal drug delivery device package with improved drug stability |
US7011843B2 (en) | 1997-10-01 | 2006-03-14 | Lts Lohmann-Therapie Systeme Ag | Method for protecting a human being against health impairment by ingestion of a transdermal therapeutic system |
US5879292A (en) | 1997-10-09 | 1999-03-09 | Edward A. Sternberg | Bandage including data acquisition components |
WO1999021834A1 (en) | 1997-10-27 | 1999-05-06 | Neurosearch A/S | Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors |
US6162214A (en) | 1997-10-30 | 2000-12-19 | Eclipse Surgical Technologies, Inc. | Corning device for myocardial revascularization |
CN1173972C (en) | 1997-11-05 | 2004-11-03 | 神经研究公司 | Azaring-ether derivatives and their use as nicotinic ach receptor modulators |
KR100648536B1 (en) | 1997-11-10 | 2006-11-24 | 셀러지 파마세우티칼스, 인크 | Penetration enhancing and irritation reducing systems |
US6374136B1 (en) | 1997-12-22 | 2002-04-16 | Alza Corporation | Anhydrous drug reservoir for electrolytic transdermal delivery device |
WO1999032095A1 (en) | 1997-12-22 | 1999-07-01 | Alza Corporation | Rate controlling membranes for controlled drug delivery devices |
US6059736A (en) | 1998-02-24 | 2000-05-09 | Tapper; Robert | Sensor controlled analysis and therapeutic delivery system |
CA2231968A1 (en) | 1998-03-11 | 1999-09-11 | Smoke-Stop, A Partnership Consisting Of Art Slutsky | Method of producing a nicotine medicament |
JP4425465B2 (en) | 1998-03-23 | 2010-03-03 | エラン コーポレーション ピーエルシー | Drug delivery device |
US6057446A (en) | 1998-04-02 | 2000-05-02 | Crooks; Peter Anthony | Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds |
US5945123A (en) | 1998-04-02 | 1999-08-31 | K-V Pharmaceutical Company | Maximizing effectiveness of substances used to improve health and well being |
US20040062802A1 (en) | 1998-04-02 | 2004-04-01 | Hermelin Victor M. | Maximizing effectiveness of substances used to improve health and well being |
EP0955301A3 (en) | 1998-04-27 | 2001-04-18 | Pfizer Products Inc. | 7-aza-bicyclo[2.2.1]-heptane derivatives, their preparation and use according to their affinity for neuronal nicotinic acetylcholine receptors |
US6211194B1 (en) | 1998-04-30 | 2001-04-03 | Duke University | Solution containing nicotine |
US6232316B1 (en) | 1998-06-16 | 2001-05-15 | Targacept, Inc. | Methods for treatment of CNS disorders |
US5967789A (en) | 1998-07-30 | 1999-10-19 | Smoke Stoppers International, Inc. | Method and system for stopping or modifying undesirable health-related behavior habits or maintaining desirable health-related behavior habits |
US6368625B1 (en) | 1998-08-12 | 2002-04-09 | Cima Labs Inc. | Orally disintegrable tablet forming a viscous slurry |
US6365182B1 (en) | 1998-08-12 | 2002-04-02 | Cima Labs Inc. | Organoleptically pleasant in-mouth rapidly disintegrable potassium chloride tablet |
ATE273298T1 (en) | 1998-08-25 | 2004-08-15 | Ortho Mcneil Pharm Inc | PYRIDYL ETHER AND THIOETHER AS NICOTINE-ACETYLCHOLINE RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATION |
US6262124B1 (en) | 1998-10-22 | 2001-07-17 | Gary Maurice Dull | Pharmaceutical compositions and methods for use |
US6211296B1 (en) | 1998-11-05 | 2001-04-03 | The B. F. Goodrich Company | Hydrogels containing substances |
AU761055B2 (en) | 1998-11-27 | 2003-05-29 | Neurosearch A/S | 8-azabicyclo(3.2.1)oct-2-ene and -octane derivatives |
FR2786769B1 (en) | 1998-12-04 | 2002-10-25 | Synthelabo | 2,5-DIAZABICYCLO [2.2.1] HEPTANE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
FR2786770B1 (en) | 1998-12-04 | 2001-01-19 | Synthelabo | NONANE 1,4-DIAZABICYCLO [3.2.2.] DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
AU2368600A (en) | 1998-12-16 | 2000-07-03 | University Of South Florida | Exo-s-mecamylamine formulation and use in treatment |
KR100383252B1 (en) | 1998-12-17 | 2003-07-16 | 주식회사 삼양사 | Transdermal Dosage Compositions Containing Buprenoline and Patches Comprising the Same |
CZ20012716A3 (en) | 1999-01-29 | 2001-11-14 | Abbott Laboratories | Diazabicyclic derivatives functioning as ligands of acetylcholine nicotine receptor |
US6583160B2 (en) | 1999-04-14 | 2003-06-24 | Steve Smith | Nicotine therapy method and oral carrier for assuaging tobacco-addiction |
US6416471B1 (en) | 1999-04-15 | 2002-07-09 | Nexan Limited | Portable remote patient telemonitoring system |
US6454708B1 (en) | 1999-04-15 | 2002-09-24 | Nexan Limited | Portable remote patient telemonitoring system using a memory card or smart card |
ATE245153T1 (en) | 1999-04-26 | 2003-08-15 | Neurosearch As | HETEROARYL-DIAZACYCLOALKANES, THEIR PREPARATION AND USE |
EP1177198B1 (en) | 1999-04-29 | 2002-11-20 | Dow Global Technologies Inc. | Bis(n,n-dihydrocarbylamino)- substituted cyclopentadienes and metal complexes thereof |
US6689380B1 (en) | 1999-05-17 | 2004-02-10 | Kevin S. Marchitto | Remote and local controlled delivery of pharmaceutical compounds using electromagnetic energy |
DE60044084D1 (en) | 1999-06-04 | 2010-05-12 | Georgia Tech Res Inst | DEVICES FOR THE ENLARGED PENETRATION OF MICRONEDES IN BIOLOGICAL HARDENING |
DE19925613A1 (en) | 1999-06-04 | 2000-12-07 | Lohmann Therapie Syst Lts | Composite laminate and process for its manufacture |
US6567785B2 (en) | 1999-06-19 | 2003-05-20 | John Richard Clendenon | Electronic behavior modification reminder system and method |
DE19958554C2 (en) | 1999-07-02 | 2002-06-13 | Lohmann Therapie Syst Lts | Microreservoir system based on polysiloxanes and ambiphilic solvents and their manufacture |
US20040229908A1 (en) | 1999-07-13 | 2004-11-18 | Jodi Nelson | Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias |
US20080138399A1 (en) | 1999-07-16 | 2008-06-12 | Aradigm Corporation | Dual release nicotine formulations, and systems and methods for their use |
US20080138398A1 (en) | 1999-07-16 | 2008-06-12 | Aradigm Corporation | Dual release nicotine formulations, and systems and methods for their use |
US6799576B2 (en) | 1999-07-16 | 2004-10-05 | Aradigm Corporation | System for effecting smoking cessation |
JP4999245B2 (en) | 1999-07-16 | 2012-08-15 | アラディグム コーポレイション | System for achieving quit smoking |
US8256433B2 (en) | 1999-07-16 | 2012-09-04 | Aradigm Corporation | Systems and methods for effecting cessation of tobacco use |
US20080138294A1 (en) | 1999-07-16 | 2008-06-12 | Igor Gonda | Systems and methods for effecting cessation of tobacco use |
US8188043B2 (en) | 1999-07-28 | 2012-05-29 | The Board Of Trustees Of The Leland Stanford Jr. University | Nicotine in therapeutic angiogenesis and vasculogenesis |
JP4397558B2 (en) | 1999-08-18 | 2010-01-13 | マイクロチップス・インコーポレーテッド | Thermally driven microchip chemical delivery device |
US7376700B1 (en) | 1999-08-23 | 2008-05-20 | Wellcoaches Corporation | Personal coaching system for clients with ongoing concerns such as weight loss |
FR2798065B1 (en) | 1999-09-02 | 2003-09-05 | Assist Publ Hopitaux De Paris | USE OF NICOTINE OR DERIVATIVES THEREOF IN A MEDICAMENT FOR THE TREATMENT OF NEUROLOGICAL DISEASES, ESPECIALLY PARKINSON'S DISEASE |
KR20010036685A (en) | 1999-10-11 | 2001-05-07 | 김윤 | Transdermal fentanyl delivery matrix system |
SE9903998D0 (en) | 1999-11-03 | 1999-11-03 | Astra Ab | New compounds |
WO2001037814A1 (en) | 1999-11-23 | 2001-05-31 | Robert Gordon University | Bilayered buccal tablets comprising nicotine |
US6539250B1 (en) | 1999-12-15 | 2003-03-25 | David S. Bettinger | Programmable transdermal therapeutic apparatus |
AU3104301A (en) | 2000-01-20 | 2001-07-31 | Noven Pharmaceuticals, Inc. | Compositions and methods to effect the release profile in the transdermal administration of active agents |
US6261595B1 (en) | 2000-02-29 | 2001-07-17 | Zars, Inc. | Transdermal drug patch with attached pocket for controlled heating device |
JP2001261652A (en) | 2000-03-21 | 2001-09-26 | Suntory Ltd | Disubstituted iminoheterocyclic compound |
AU2000258901A1 (en) | 2000-04-06 | 2001-10-23 | Nicholas V. Perricone | Treatment of skin damage using olive oil polyphenols |
US6489025B2 (en) | 2000-04-12 | 2002-12-03 | Showa Denko K.K. | Fine carbon fiber, method for producing the same and electrically conducting material comprising the fine carbon fiber |
US6955821B2 (en) | 2000-04-28 | 2005-10-18 | Adams Laboratories, Inc. | Sustained release formulations of guaifenesin and additional drug ingredients |
JP4098985B2 (en) | 2000-05-19 | 2008-06-11 | サビンサ コーポレーション | Methods for enhancing the bioavailability of nutrients and pharmaceutical preparations using tetrahydropiperine and analogs and derivatives thereof |
CA2688795C (en) | 2000-06-01 | 2014-07-08 | Science Application International Corporation | Systems and methods for monitoring health and delivering drugs transdermally |
EP1662989B1 (en) | 2000-06-16 | 2014-09-03 | BodyMedia, Inc. | System for monitoring and managing body weight and other physiological conditions including iterative and personalized planning, intervention and reporting capability |
WO2002002081A1 (en) | 2000-07-05 | 2002-01-10 | Capricorn Pharma, Inc. | Rapid-melt semi-solid compositions, methods of making same and methods of using same |
US6589229B1 (en) | 2000-07-31 | 2003-07-08 | Becton, Dickinson And Company | Wearable, self-contained drug infusion device |
JP2002092180A (en) | 2000-09-19 | 2002-03-29 | Hiroko Takahashi | System for supporting abstention from smoking |
EP1330236A2 (en) | 2000-10-12 | 2003-07-30 | Beecham Pharmaceuticals (Pte) Limited | Formulation containing amoxicillin |
GB0026137D0 (en) | 2000-10-25 | 2000-12-13 | Euro Celtique Sa | Transdermal dosage form |
US6569449B1 (en) | 2000-11-13 | 2003-05-27 | University Of Kentucky Research Foundation | Transdermal delivery of opioid antagonist prodrugs |
US6682757B1 (en) | 2000-11-16 | 2004-01-27 | Euro-Celtique, S.A. | Titratable dosage transdermal delivery system |
DE10102817B4 (en) | 2001-01-23 | 2006-01-12 | Lts Lohmann Therapie-Systeme Ag | Device and method for heat pulse-assisted transdermal application of active substances |
DE10103158A1 (en) | 2001-01-24 | 2002-08-01 | Christian Von Falkenhausen | Device for electricity-assisted introduction of active agents into the skin comprises at least two electrodes which are connected through galvanic conduction of the reservoir of the active agent |
DE10105759C1 (en) | 2001-02-08 | 2001-10-25 | Lohmann Therapie Syst Lts | Electrically and magnetically assisted charge carrier delivery device e.g. for transdermal application of pharmaceuticals, has electrical and magnetic fields applied to charge carrier reservoir layer |
CN1556716A (en) | 2001-02-22 | 2004-12-22 | ���Ͽع�����˾ | Modular infusion device and method |
BR0207663A (en) | 2001-02-27 | 2005-10-25 | Univ Michigan | Use of natural egfr inhibitors to prevent side effects due to therapy with retinoids, soaps and other stimuli that activate the epidermal growth factor receptor. |
US20020127256A1 (en) | 2001-03-01 | 2002-09-12 | Howard Murad | Compositions and methods for treating dermatological disorders |
FR2822377A1 (en) | 2001-03-23 | 2002-09-27 | Oreal | USE OF FIBERS AS ANTI-IRRITANT AGENT IN A COSMETIC OR DERMATOLOGICAL COMPOSITION |
NZ528167A (en) | 2001-03-26 | 2005-04-29 | Smithkline Beecham Corp | Nicotine-containing oral dosage form |
EP1372668B1 (en) | 2001-03-26 | 2011-12-07 | Dana-Farber Cancer Institute, Inc. | Method of attenuating reactions to skin irritants |
CA2381630A1 (en) | 2001-04-23 | 2002-10-23 | Leonard Theodore Meltzer | Method for preventing dyskinesias |
PT1397095E (en) | 2001-05-01 | 2009-02-17 | Euro Celtique Sa | Abuse resistant opioid containing transdermal systems |
US6723086B2 (en) | 2001-05-07 | 2004-04-20 | Logiq Wireless Solutions, Inc. | Remote controlled transdermal medication delivery device |
US20040019321A1 (en) | 2001-05-29 | 2004-01-29 | Sage Burton H. | Compensating drug delivery system |
SE0102197D0 (en) | 2001-06-20 | 2001-06-20 | Pharmacia Ab | New product and use and manufacture thereof |
US20030044458A1 (en) | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
US7332182B2 (en) | 2001-08-06 | 2008-02-19 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant |
US6576269B1 (en) | 2001-09-06 | 2003-06-10 | Alexander Y. Korneyev | Treating open skin lesions using extract of sea buckthorn |
GB0121628D0 (en) | 2001-09-07 | 2001-10-31 | Watmough David J | Improved method and apparatus for transdermal drug delivery |
FR2829644A1 (en) | 2001-09-10 | 2003-03-14 | St Microelectronics Sa | Internet digital word watermarking transmission having symmetrical algorithm authentication key before transmission and authentication key watermarking phase and transmission watermarked words |
US7615234B2 (en) | 2001-09-11 | 2009-11-10 | Glide Pharmaceutical Technologies Limited | Drug delivery technology |
US20060122577A1 (en) | 2001-09-26 | 2006-06-08 | Poulsen Jens U | Modular drug delivery system |
SE0103211D0 (en) | 2001-09-27 | 2001-09-27 | Pharmacia Ab | New formulations and use thereof |
US6723077B2 (en) | 2001-09-28 | 2004-04-20 | Hewlett-Packard Development Company, L.P. | Cutaneous administration system |
US6893655B2 (en) | 2001-10-09 | 2005-05-17 | 3M Innovative Properties Co. | Transdermal delivery devices |
US20030119879A1 (en) | 2001-10-15 | 2003-06-26 | Thomas Landh | Nicotine and chocolate compositions |
US20030087937A1 (en) | 2001-10-15 | 2003-05-08 | Nils-Olof Lindberg | Nicotine and cocoa powder compositions |
US6723340B2 (en) | 2001-10-25 | 2004-04-20 | Depomed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
TWI312285B (en) | 2001-10-25 | 2009-07-21 | Depomed Inc | Methods of treatment using a gastric retained gabapentin dosage |
US7429258B2 (en) | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
US20040037879A1 (en) | 2001-11-02 | 2004-02-26 | Adusumilli Prasad S. | Oral controlled release forms useful for reducing or preventing nicotine cravings |
US8329217B2 (en) | 2001-11-06 | 2012-12-11 | Osmotica Kereskedelmi Es Szolgaltato Kft | Dual controlled release dosage form |
US7614857B2 (en) | 2001-11-16 | 2009-11-10 | Medinnovation Ag | Medical pump device |
US7311693B2 (en) | 2001-11-26 | 2007-12-25 | Nilimedix Ltd. | Drug delivery device and method |
US20040052843A1 (en) | 2001-12-24 | 2004-03-18 | Lerner E. Itzhak | Controlled release dosage forms |
SE0104388D0 (en) | 2001-12-27 | 2001-12-27 | Pharmacia Ab | New formulation and use and manufacture thereof |
US6852741B2 (en) | 2001-12-31 | 2005-02-08 | University Of Florida | Compositions and methods for treatment of neurological disorders |
JP2005518411A (en) | 2002-01-16 | 2005-06-23 | エンド ファーマシューティカルズ インコーポレーテッド | Pharmaceutical compositions and methods for treating disorders of the central nervous system |
EP1471838A2 (en) | 2002-01-16 | 2004-11-03 | Encapsulation Systems, Inc | Substance delivery device |
US20030159702A1 (en) | 2002-01-21 | 2003-08-28 | Lindell Katarina E.A. | Formulation and use manufacture thereof |
US7004928B2 (en) | 2002-02-08 | 2006-02-28 | Rosedale Medical, Inc. | Autonomous, ambulatory analyte monitor or drug delivery device |
US20040033253A1 (en) | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
US6861066B2 (en) | 2002-03-11 | 2005-03-01 | Health Plus International Inc. | Method for the delivery of a biologically active agent |
CA2929300C (en) | 2002-03-11 | 2019-04-16 | Nitto Denko Corporation | Transdermal drug delivery patch system, method of making same and method of using same |
US20070168501A1 (en) | 2002-03-29 | 2007-07-19 | Cobb Nathan K | Method and system for delivering behavior modification information over a network |
US6780171B2 (en) | 2002-04-02 | 2004-08-24 | Becton, Dickinson And Company | Intradermal delivery device |
MXPA04010612A (en) | 2002-04-23 | 2005-07-14 | Alza Corp | Transdermal analgesic systems with reduced abuse potential. |
WO2003092764A2 (en) | 2002-04-29 | 2003-11-13 | Kevin Marchitto | Controlled release transdermal drug delivery |
US7417013B2 (en) | 2002-05-01 | 2008-08-26 | Mcneil-Ppc, Inc. | Warming and nonirritating lubricant compositions and method of comparing irritation |
WO2003094900A1 (en) | 2002-05-13 | 2003-11-20 | Alexza Molecular Delivery Corporation | Delivery of drug amines through an inhalation route |
US20040166159A1 (en) | 2002-05-29 | 2004-08-26 | Chien-Hsuan Han | Pharmaceutical dosage forms having immediate and controlled release properties that contain an aromatic amino acid decarboxylase inhibitor and levodopa |
US7767698B2 (en) | 2002-06-03 | 2010-08-03 | Mcneil Ab | Formulation and use thereof |
EA007240B1 (en) | 2002-06-10 | 2006-08-25 | Еуро-Селтик С. А. | Transdermal delivery device disposal system |
AU2002356419A1 (en) | 2002-06-17 | 2003-12-31 | Themis Laboratories Private Limited | Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them |
US8586079B2 (en) | 2002-06-21 | 2013-11-19 | Graphic Productions Inc. | Promotional simulation for transdermal patch sampler |
AU2003280136A1 (en) | 2002-06-28 | 2004-01-19 | Alza Corporation | A reservoir for use in an electrotransport drug delivery device |
US7196619B2 (en) | 2002-06-29 | 2007-03-27 | Neil Perlman | Habit cessation aide |
DE10240165A1 (en) | 2002-08-30 | 2004-03-18 | Disetronic Licensing Ag | Dispensing unit for use in infusion pumps comprises reservoir for infusion liquid fitted with spring-loaded piston, toothed wheel cooperating with locking bar to prevent piston moving |
KR20050059072A (en) | 2002-08-30 | 2005-06-17 | 알자 코포레이션 | Embossable and writable multilaminate backing construction |
US20040052851A1 (en) | 2002-09-16 | 2004-03-18 | Graff Allan H. | Modified release oral dosage form |
US20040259816A1 (en) | 2002-10-01 | 2004-12-23 | Pandol Stephen J. | Compositions comprising plant-derived polyphenolic compounds and inhibitors of reactive oxygen species and methods of using thereof |
US7399401B2 (en) | 2002-10-09 | 2008-07-15 | Abbott Diabetes Care, Inc. | Methods for use in assessing a flow condition of a fluid |
US8999372B2 (en) | 2002-11-14 | 2015-04-07 | Cure Pharmaceutical Corporation | Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use |
NO346973B1 (en) | 2002-12-20 | 2023-03-20 | Niconovum Ab | A physically and chemically stable nicotine-containing particulate material |
US7887842B2 (en) | 2003-02-07 | 2011-02-15 | Teikoku Pharma Usa, Inc. | Methods of administering a dermatological agent to a subject |
AU2003900769A0 (en) | 2003-02-21 | 2003-03-13 | Francis Paul Galea | Medication and smoking cessation watch |
JP2004310742A (en) | 2003-03-26 | 2004-11-04 | Hitachi Ltd | Service processing method and device |
AU2004228038A1 (en) | 2003-04-02 | 2004-10-21 | Advancis Pharmaceutical Corporation | Pulsatile transdermally administered antigens and adjuvants |
US7182955B2 (en) | 2003-04-30 | 2007-02-27 | 3M Innovative Properties Company | Abuse-resistant transdermal dosage form |
SE0301320D0 (en) | 2003-05-06 | 2003-05-06 | Astrazeneca Ab | Positive modulators of nicotinic acetylcholine receptors |
WO2004103283A2 (en) | 2003-05-14 | 2004-12-02 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a central nervous system stimulant for the treatment of central nervous system damage |
US8021334B2 (en) | 2004-05-30 | 2011-09-20 | Nilimedix Ltd. | Drug delivery device and method |
US20050048020A1 (en) | 2003-07-07 | 2005-03-03 | Wille John J. | Novel topical delivery system for plant derived anti-irritants |
US7231839B2 (en) | 2003-08-11 | 2007-06-19 | The Board Of Trustees Of The Leland Stanford Junior University | Electroosmotic micropumps with applications to fluid dispensing and field sampling |
DE10338174A1 (en) | 2003-08-20 | 2005-03-24 | Lts Lohmann Therapie-Systeme Ag | Transdermal drug formulations with drug combinations for the treatment of Parkinson's disease |
US7282217B1 (en) | 2003-08-29 | 2007-10-16 | Kv Pharmaceutical Company | Rapidly disintegrable tablets |
DK1663168T3 (en) | 2003-09-08 | 2009-06-08 | Mcneil Ab | Nicotine formulations and their use |
NZ546662A (en) | 2003-10-20 | 2009-03-31 | Teva Pharma | Composition and dosage form for sustained effect of levodopa |
EP1527792A1 (en) | 2003-10-27 | 2005-05-04 | Novo Nordisk A/S | Medical injection device mountable to the skin |
ATE446111T1 (en) | 2003-10-21 | 2009-11-15 | Novo Nordisk As | INTERNAL FLUID CONNECTOR FOR PRODUCING A FLUID CONNECTION |
WO2005039685A1 (en) | 2003-10-27 | 2005-05-06 | University Of Basel | Transdermal drug delivery method and system |
CN100457064C (en) | 2003-10-28 | 2009-02-04 | 诺芬药品公司 | Transdermal drug delivery systems |
MXPA06005509A (en) | 2003-11-13 | 2007-05-23 | Johnson & Johnson | System and method for transdermal delivery. |
US8589174B2 (en) | 2003-12-16 | 2013-11-19 | Adventium Enterprises | Activity monitoring |
US20050266032A1 (en) | 2003-12-17 | 2005-12-01 | Sovereign Pharmaceuticals, Ltd. | Dosage form containing multiple drugs |
US20050141346A1 (en) | 2003-12-30 | 2005-06-30 | Rawls David K. | Smoking cessation device |
US20050151110A1 (en) | 2004-01-14 | 2005-07-14 | Minor Barbara H. | Fluoroether refrigerant compositions and uses thereof |
US7867511B2 (en) | 2004-01-23 | 2011-01-11 | Travanti Pharma Inc. | Abuse potential reduction in abusable substance dosage form |
ATE426399T1 (en) | 2004-02-23 | 2009-04-15 | Euro Celtique Sa | ABUSE-PROOF TRANSDERMAL OPIOID DELIVERY DEVICE CONTAINING OPIOID ANTAGONIST IN THE FORM OF MICROSPHERES |
IL160578A (en) | 2004-02-25 | 2013-11-28 | Newvaltech Knowledge Services And Invest Ltd | Remote coaching service and server |
RS50817B (en) | 2004-03-30 | 2010-08-31 | Euro-Celtique S.A. | Tamper resistant dosage form comprising an adsorbent and an adverse agent |
US20050226921A1 (en) | 2004-04-13 | 2005-10-13 | Kortzebom Robert N | Non-invasive analysis and controlled dosage transdermal active patch |
DE102004019916A1 (en) | 2004-04-21 | 2005-11-17 | Grünenthal GmbH | Anti-abuse drug-containing patch |
DE102004022678A1 (en) | 2004-05-05 | 2005-12-15 | Humboldt-Universität Zu Berlin | Method for controlling a volume flow of a liquid in an osmotic micropump and osmotic micropump |
CN1332667C (en) | 2004-05-26 | 2007-08-22 | 中国科学院生物物理研究所 | Compound preparation for resisting Parkinson's disease |
US7019622B2 (en) | 2004-05-27 | 2006-03-28 | Research In Motion Limited | Handheld electronic device including vibrator having different vibration intensities and method for vibrating a handheld electronic device |
US8690865B2 (en) | 2004-05-28 | 2014-04-08 | Georgia Tech Research Corporation | Methods and devices for thermal treatment |
WO2006015299A2 (en) | 2004-07-30 | 2006-02-09 | Microchips, Inc. | Multi-reservoir device for transdermal drug delivery and sensing |
EP1790375A4 (en) | 2004-08-12 | 2009-06-17 | Hisamitsu Pharmaceutical Co | Transdermal drug administration apparatus with microneedle |
DE102004044578A1 (en) | 2004-09-13 | 2006-03-30 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system with an adhesive layer, method for siliconizing a backing layer of the system and use of the backing layer |
JP5254616B2 (en) | 2004-09-13 | 2013-08-07 | クロノ セラピューティクス、インコーポレイテッド | Biosynchronous transdermal drug delivery |
WO2006041907A2 (en) | 2004-10-08 | 2006-04-20 | Noven Pharmaceuticals, Inc. | Transdermal delivery of estradiol |
CA2583340C (en) | 2004-10-08 | 2015-09-08 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery device including an occlusive backing |
US20090024004A1 (en) | 2004-10-29 | 2009-01-22 | Chang-Ming Yang | Method and Apparatus for Monitoring Body Temperature, Respiration, Heart Sound, Swallowing, and Medical Inquiring |
US8999356B1 (en) | 2004-12-03 | 2015-04-07 | Omp, Inc. | Drug delivery system |
CA2591092A1 (en) | 2004-12-17 | 2006-06-22 | Alza Corporation | Temperature modulation of transdermal drug delivery |
DE602005019094D1 (en) | 2004-12-22 | 2010-03-11 | Memory Pharmaceutical Corp | NICOTINE ALPHA-7 RECEPTOR LIGANDS AGAINST DISEASES OF THE CNS |
MX2007009152A (en) | 2005-02-01 | 2008-03-06 | Intelliject Llc | Devices, systems, and methods for medicament delivery. |
US8231573B2 (en) | 2005-02-01 | 2012-07-31 | Intelliject, Inc. | Medicament delivery device having an electronic circuit system |
US20060188859A1 (en) | 2005-02-22 | 2006-08-24 | Haim Yakobi | Method and system for computer implemented personal counseling |
US20070042026A1 (en) | 2005-03-17 | 2007-02-22 | Wille John J | Prophylactic and therapeutic treatment of topical and transdermal drug-induced skin reactions |
US8029927B2 (en) | 2005-03-22 | 2011-10-04 | Blue Spark Technologies, Inc. | Thin printable electrochemical cell utilizing a “picture frame” and methods of making the same |
US8137314B2 (en) | 2006-08-23 | 2012-03-20 | Medtronic Minimed, Inc. | Infusion medium delivery device and method with compressible or curved reservoir or conduit |
US8722233B2 (en) | 2005-05-06 | 2014-05-13 | Blue Spark Technologies, Inc. | RFID antenna-battery assembly and the method to make the same |
US7641649B2 (en) | 2005-05-06 | 2010-01-05 | Medtronic Minimed, Inc. | Reservoir support and method for infusion device |
US8688189B2 (en) | 2005-05-17 | 2014-04-01 | Adnan Shennib | Programmable ECG sensor patch |
US20070020339A1 (en) | 2005-07-20 | 2007-01-25 | Pharmorx Inc. | Compositions and methods for controlling abuse of medications |
US8566121B2 (en) | 2005-08-29 | 2013-10-22 | Narayanan Ramasubramanian | Personalized medical adherence management system |
KR20080058433A (en) | 2005-09-30 | 2008-06-25 | 티티아이 엘뷰 가부시키가이샤 | Transdermal drug delivery systems, devices, and methods employing opioid agonist and/or opioid antagonist |
US20070086275A1 (en) | 2005-10-18 | 2007-04-19 | Robinson Robert J | Electronic reminder device |
JP2009514871A (en) | 2005-11-04 | 2009-04-09 | イーストマン ケミカル カンパニー | Carboxyalkylcellulose esters for sustained delivery of pharmaceutically active substances |
JP4355722B2 (en) | 2005-11-17 | 2009-11-04 | セイコーエプソン株式会社 | Fluid transport device |
WO2007075677A2 (en) | 2005-12-20 | 2007-07-05 | Antares Pharma, Inc. | Needle-free injection device |
US20070149952A1 (en) | 2005-12-28 | 2007-06-28 | Mike Bland | Systems and methods for characterizing a patient's propensity for a neurological event and for communicating with a pharmacological agent dispenser |
EP1815784A1 (en) | 2006-02-06 | 2007-08-08 | Mashhour Mustafa Moh'd Bani Amer | System with intelligent cable-less transducers for monitoring and analysing biosignals |
CA2641583C (en) | 2006-02-09 | 2016-06-14 | Deka Products Limited Partnership | Peripheral systems |
US7958887B2 (en) | 2006-03-10 | 2011-06-14 | Aradigm Corporation | Nozzle pore configuration for intrapulmonary delivery of aerosolized formulations |
US20070299400A1 (en) | 2006-03-16 | 2007-12-27 | Seattle Medical Technologies | Infusion device with dome pump |
JP2009529343A (en) | 2006-03-16 | 2009-08-20 | ニコノヴァム エービー | Chewing gum composition providing rapid release of nicotine |
KR101568660B1 (en) | 2006-05-02 | 2015-11-12 | 프로테우스 디지털 헬스, 인코포레이티드 | Patient customized therapeutic regimens |
US20070260491A1 (en) | 2006-05-08 | 2007-11-08 | Pamela Palmer | System for delivery and monitoring of administration of controlled substances |
US7558622B2 (en) | 2006-05-24 | 2009-07-07 | Bao Tran | Mesh network stroke monitoring appliance |
US8684922B2 (en) | 2006-05-12 | 2014-04-01 | Bao Tran | Health monitoring system |
US20070269492A1 (en) | 2006-05-16 | 2007-11-22 | Per Steen | New product and use and manufacture thereof |
US20070279217A1 (en) | 2006-06-01 | 2007-12-06 | H-Micro, Inc. | Integrated mobile healthcare system for cardiac care |
US8614278B2 (en) | 2006-06-06 | 2013-12-24 | Dow Corning Corporation | Silicone acrylate hybrid composition and method of making same |
DE102006028987A1 (en) | 2006-06-24 | 2007-12-27 | Lts Lohmann Therapie-Systeme Ag | Ultrasound-enhanced transdermal therapeutic system |
US20080008747A1 (en) | 2006-07-07 | 2008-01-10 | Royds Robert B | Transdermal patch |
KR101329496B1 (en) | 2006-07-21 | 2013-11-13 | 바이오딜리버리 사이언시스 인터내셔널 인코포레이티드 | Transmucosal delivery devices with enhanced uptake |
US9248104B2 (en) | 2006-08-17 | 2016-02-02 | Core Tech Solutions, Inc. | Transdermal methods and systems for treating Alzheimer's disease |
WO2008024408A2 (en) | 2006-08-22 | 2008-02-28 | Theraquest Biosciences, Inc. | Pharmaceutical formulations of cannabinoids for application to the skin and method of use |
EP2562177A3 (en) | 2006-09-22 | 2013-04-10 | AllTranz Inc. | Transdermally deliverable buprenorphine prodrugs and abuse-resistant compositions thereof |
WO2008054788A2 (en) | 2006-10-31 | 2008-05-08 | Chrono Therapeutics, Inc. | Transdermal delivery techniques for drugs, nutraceuticals and other active substances |
AU2007314150B2 (en) | 2006-11-01 | 2009-06-04 | Smartvet Pty Ltd | Delivery system for remote treatment of an animal |
AU2007325918B2 (en) | 2006-11-03 | 2013-10-17 | Durect Corporation | Transdermal delivery systems comprising bupivacaine |
DE102006054731B4 (en) | 2006-11-21 | 2013-02-28 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system for administration of the active ingredient buprenorphine and use thereof in pain therapy |
DE102006054733A1 (en) | 2006-11-21 | 2008-05-29 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system with high drug utilization rate and dosing accuracy |
WO2008069970A2 (en) | 2006-12-01 | 2008-06-12 | Aradigm Corporation | Nicotine formulations, kits and systems and methods for their use |
WO2008069921A2 (en) | 2006-12-01 | 2008-06-12 | Cima Labs Inc. | Oral transmucosal nicotine dosage form |
US20080152592A1 (en) | 2006-12-21 | 2008-06-26 | Bayer Healthcare Llc | Method of therapeutic drug monitoring |
EP2104525A4 (en) | 2006-12-29 | 2010-12-29 | Amir Genosar | Hypodermic drug delivery reservoir and apparatus |
WO2008091838A2 (en) | 2007-01-22 | 2008-07-31 | Intelliject, Inc. | Medical injector with compliance tracking and monitoring |
US20080195946A1 (en) | 2007-02-13 | 2008-08-14 | Cadence Design Systems, Inc. | Online personal coach for software applications |
US20080199407A1 (en) | 2007-02-15 | 2008-08-21 | Slater Kenneth C | Drug Detoxification Protocol Using Microdosing |
JP2010518914A (en) | 2007-02-16 | 2010-06-03 | ヴィロ・ゲームス・リミテッド | Biosensor device and method |
US7931563B2 (en) | 2007-03-08 | 2011-04-26 | Health Hero Network, Inc. | Virtual trainer system and method |
US7718677B2 (en) | 2007-04-02 | 2010-05-18 | Parkinson's Institute | Methods and compositions for reduction of side effects of therapeutic treatments |
US20180110768A1 (en) | 2007-04-02 | 2018-04-26 | Parkinson's Institute | Methods and compositions for reduction of side effects of therapeutic treatments |
EP2152148A2 (en) | 2007-05-07 | 2010-02-17 | Medingo Ltd. | Reciprocating delivery of fluids to the body with analyte concentration monitoring |
DE102007021549A1 (en) | 2007-05-08 | 2008-11-13 | Novosis Ag | Transdermal therapeutic system containing at least two opioids |
WO2008139460A2 (en) | 2007-05-11 | 2008-11-20 | Medingo Ltd. | A modular skin-patch type medical fluid delivery device |
US9597029B2 (en) | 2007-06-19 | 2017-03-21 | Cardiac Pacemakers, Inc. | System and method for remotely evaluating patient compliance status |
US20090005009A1 (en) | 2007-06-28 | 2009-01-01 | Yolanda Marsili | Habit Braker On The Go Motivational Support System for Diet, Exercise and Quit Smoking |
US9173991B2 (en) | 2007-07-02 | 2015-11-03 | Roche Diabetes Care, Inc. | Device for drug delivery |
US20090010998A1 (en) | 2007-07-03 | 2009-01-08 | Marchitto Kevin S | Drug-delivery patch comprising a dissolvable layer and uses thereof |
US20100178323A1 (en) | 2007-07-10 | 2010-07-15 | Agis Kydonieus | Dermal Delivery Device |
EP2176814A4 (en) | 2007-07-18 | 2012-06-13 | Blue Spark Technologies Inc | Integrated electronic device and methods of making the same |
EP2178583B1 (en) * | 2007-07-20 | 2014-02-12 | Medingo Ltd. | Vented dispensing device |
WO2009016635A2 (en) | 2007-08-01 | 2009-02-05 | Medingo Ltd. | Detachable portable infusion device |
EP2022518A1 (en) | 2007-08-07 | 2009-02-11 | Sensile Pat AG | Modular drug delivery device for administering discrete doses of a medicament |
US9017301B2 (en) | 2007-09-04 | 2015-04-28 | Mylan Technologies, Inc. | Transdermal drug delivery systems comprising a coated release liner |
WO2009076236A2 (en) | 2007-12-06 | 2009-06-18 | Pain Therapeutics, Inc. | Micronized opioid compositions, formulations and dosage forms and methods of making same |
MX2010006699A (en) | 2007-12-17 | 2010-11-30 | New World Pharmaceuticals Llc | Integrated intra-dermal delivery, diagnostic and communication system. |
US9044542B2 (en) | 2007-12-21 | 2015-06-02 | Carticept Medical, Inc. | Imaging-guided anesthesia injection systems and methods |
US20110160640A1 (en) | 2008-01-18 | 2011-06-30 | Yanaki Jamal S | Operation management of active transdermal medicament patch |
US8862223B2 (en) | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
WO2009105337A2 (en) | 2008-02-20 | 2009-08-27 | Dexcom, Inc. | Continuous medicament sensor system for in vivo use |
US9700552B2 (en) | 2008-02-28 | 2017-07-11 | Syntropharma Limited | Pharmaceutical compositions for treatment of addiction |
US9107668B2 (en) | 2008-03-25 | 2015-08-18 | Cook Medical Technologies Llc | Embolic particle mixing syringe |
US20090246265A1 (en) | 2008-03-26 | 2009-10-01 | Alltranz Inc. | Abuse deterrent transdermal formulations of opiate agonists and agonist-antagonists |
US20090259176A1 (en) | 2008-04-09 | 2009-10-15 | Los Gatos Research, Inc. | Transdermal patch system |
WO2009136304A2 (en) | 2008-05-05 | 2009-11-12 | Koninklijke Philips Electronics N.V. | Disposable drug cartridge |
ITMI20080825A1 (en) | 2008-05-07 | 2009-11-08 | Paolo Borlenghi | INTERPERSONAL COMMUNICATION SYSTEM |
US10064819B2 (en) | 2008-05-12 | 2018-09-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
US20100248198A1 (en) | 2008-06-16 | 2010-09-30 | Cerebyte, Inc. | Computer-based first-person behavioral change methodology |
US7976500B2 (en) | 2008-06-26 | 2011-07-12 | Calibra Medical, Inc. | Disposable infusion device with redundant valved safety |
US20100003653A1 (en) | 2008-07-04 | 2010-01-07 | Wendell Brown | System and method for automated behavioral coaching |
US7967785B2 (en) * | 2008-07-14 | 2011-06-28 | Nipro Healthcare Systems, Llc | Insulin reservoir detection via magnetic switching |
CA2930329A1 (en) | 2008-08-18 | 2010-02-25 | Calibra Medical, Inc. | Drug infusion system with reusable and disposable components |
DK2385851T3 (en) | 2008-09-05 | 2015-03-23 | Hoffmann La Roche | Infusion pump for adhering ON SKIN INCLUDING AN RESONANS SUMMER |
US8876802B2 (en) | 2008-09-15 | 2014-11-04 | Leonid Grigorov | Methods and devices for programmable delivery of microdoses of liquid drugs |
US8632497B2 (en) | 2008-10-09 | 2014-01-21 | Roche Diagnostics Operations Inc. | Skin securable drug delivery device with a shock absorbing protective shield |
EP2198903A1 (en) | 2008-12-19 | 2010-06-23 | Sanofi-Aventis Deutschland GmbH | Motor mechanism for a drug delivery device and drug delivery device |
US20120156138A1 (en) | 2009-04-14 | 2012-06-21 | Smith Larry J | Methods and Compositions for the Treatment of Medical Conditions Involving Cellular Reprogramming |
US8140143B2 (en) | 2009-04-16 | 2012-03-20 | Massachusetts Institute Of Technology | Washable wearable biosensor |
US8655441B2 (en) | 2009-04-16 | 2014-02-18 | Massachusetts Institute Of Technology | Methods and apparatus for monitoring patients and delivering therapeutic stimuli |
US20100273738A1 (en) | 2009-04-23 | 2010-10-28 | Valcke Christian P | Integrated patient management and control system for medication delivery |
EP2459267B1 (en) | 2009-07-31 | 2017-12-20 | 3M Innovative Properties Company | Hollow microneedle arrays |
JP5558047B2 (en) | 2009-08-13 | 2014-07-23 | 深江化成株式会社 | Substance supply device |
US8303500B2 (en) | 2009-08-21 | 2012-11-06 | Fazal Raheman | Prescription zero: a non-pharmaceutical prescription device for prescribing, administering, monitoring, measuring and motivating a therapeutic lifestyle regimen for prevention and treatment of chronic diseases |
US9824606B2 (en) | 2009-08-28 | 2017-11-21 | International Business Machines Corporation | Adaptive system for real-time behavioral coaching and command intermediation |
US10092691B2 (en) | 2009-09-02 | 2018-10-09 | Becton, Dickinson And Company | Flexible and conformal patch pump |
EP2295046B1 (en) | 2009-09-14 | 2012-12-19 | Acino AG | Transdermal therapeutic system for application of fentanyl or an analogue material thereof |
KR101325104B1 (en) | 2009-09-16 | 2013-11-07 | 주식회사 삼양바이오팜 | Transdermal delivery system and method for manufacturing the same |
US8666781B2 (en) | 2009-12-23 | 2014-03-04 | Ai Cure Technologies, LLC | Method and apparatus for management of clinical trials |
US20110153360A1 (en) | 2009-12-23 | 2011-06-23 | Al Cure Technologies LLC | Method and Apparatus for Verification of Clinical Trial Adherence |
CN102762243B (en) | 2009-12-14 | 2014-07-23 | Shl集团有限责任公司 | Medicament delivery device |
PL2515886T3 (en) | 2009-12-22 | 2018-08-31 | Luye Pharma Ag | Transdermal therapeutic system for administering rivastigmine or derivatives thereof |
US20110152635A1 (en) | 2009-12-23 | 2011-06-23 | Morris Margaret E | Motivational Profiling for Behavioral Change Technologies: A State-Trait Approach |
US8998840B2 (en) | 2009-12-30 | 2015-04-07 | Medtronic Minimed, Inc. | Connection and alignment systems and methods |
WO2011086505A1 (en) | 2010-01-14 | 2011-07-21 | Sensile Pat Ag | Skin mounted medical patch device |
WO2011088072A2 (en) | 2010-01-14 | 2011-07-21 | Agile Therapeutics, Inc. | Dermal delivery device |
US8872663B2 (en) | 2010-01-19 | 2014-10-28 | Avery Dennison Corporation | Medication regimen compliance monitoring systems and methods |
US20110245633A1 (en) | 2010-03-04 | 2011-10-06 | Neumitra LLC | Devices and methods for treating psychological disorders |
US20110250576A1 (en) | 2010-03-16 | 2011-10-13 | Reid Kevin Hester | System and method for recovering form addictions |
US9327105B2 (en) | 2010-03-26 | 2016-05-03 | Itrace Biomedical Inc. | Active transdermal drug delivery system and the method thereof |
EP2552486B1 (en) | 2010-03-30 | 2020-08-12 | Phosphagenics Limited | Transdermal delivery patch |
US20110241446A1 (en) | 2010-03-30 | 2011-10-06 | Blue Spark Technologies, Inc. | Irreversible circuit activation switch |
WO2011123866A1 (en) | 2010-04-02 | 2011-10-06 | Alltranz Inc. | Abuse-deterrent transdermal formulations of opiate agonists and agonist-antagonists |
CN103108665A (en) | 2010-04-20 | 2013-05-15 | 迷你泵有限责任公司 | Electrolytically driven drug pump devices |
US20110256517A1 (en) | 2010-04-20 | 2011-10-20 | Alaster Drew Swanson | Computer aided real-time behavior coaching |
CA2796186C (en) | 2010-04-21 | 2019-04-09 | Abbott Biotechnology Ltd. | Wearable automatic injection device for controlled delivery of therapeutic agents |
US9655546B2 (en) | 2010-04-22 | 2017-05-23 | Leaf Healthcare, Inc. | Pressure Ulcer Detection Methods, Devices and Techniques |
US20110268809A1 (en) | 2010-04-28 | 2011-11-03 | Paul Andrew Brinkley | Nicotine-Containing Pharmaceutical Compositions |
AU2011284804A1 (en) | 2010-07-30 | 2013-03-21 | Intheshed Australia Pty Ltd | An improved event tag |
US9173994B2 (en) | 2010-08-20 | 2015-11-03 | Purdue Research Foundation | Touch-actuated micropump for transdermal drug delivery and method of use |
US20120203573A1 (en) | 2010-09-22 | 2012-08-09 | I.D. Therapeutics Llc | Methods, systems, and apparatus for optimizing effects of treatment with medication using medication compliance patterns |
US8915879B2 (en) | 2010-09-24 | 2014-12-23 | Perqflo, Llc | Infusion pumps |
US9390427B2 (en) | 2010-09-30 | 2016-07-12 | Fitbit, Inc. | Methods, systems and devices for automatic linking of activity tracking devices to user devices |
US20120171277A1 (en) | 2011-01-03 | 2012-07-05 | Royds Robert B | Abuse resistant transdermal drug delivery patch including a release-enhanced antagonist |
US20120178065A1 (en) | 2011-01-10 | 2012-07-12 | Morteza Naghavi | Advanced Button Application for Individual Self-Activating and Monitored Control System in Weight Loss Program |
US20130253430A1 (en) | 2011-01-18 | 2013-09-26 | Sanofi-Aventis Deutschland Gmbh | Multi-Reservoir Pump Patch |
CA2825142A1 (en) | 2011-01-27 | 2012-08-02 | Novartis Ag | Use of nicotinic acetylcholine receptor alpha 7 activators |
US8753315B2 (en) | 2011-02-17 | 2014-06-17 | Calibra Medical, Inc. | Manual basal bolus drug delivery device |
WO2012116116A1 (en) | 2011-02-22 | 2012-08-30 | Saul Rosenberg | Systems and methods for selecting, ordering, scheduling, administering, storing, interpreting and transmitting a plurality of psychological, neurobehavioral and neurobiological tests |
US8696637B2 (en) | 2011-02-28 | 2014-04-15 | Kimberly-Clark Worldwide | Transdermal patch containing microneedles |
US20120244503A1 (en) | 2011-03-22 | 2012-09-27 | Carrie Neveldine | Method of Attention Recovery and Behavioral Modification |
EP2510962A1 (en) | 2011-04-12 | 2012-10-17 | F. Hoffmann-La Roche AG | Infusion pump device with re-filling scheme for cylinder-piston dosing unit |
US20120316896A1 (en) | 2011-06-10 | 2012-12-13 | Aliphcom | Personal advisor system using data-capable band |
US20120329017A1 (en) | 2011-06-23 | 2012-12-27 | Pham Vu H | Method and system of coaching behavior |
US8758826B2 (en) | 2011-07-05 | 2014-06-24 | Wet Inc. | Cannabinoid receptor binding agents, compositions, and methods |
US20130017259A1 (en) | 2011-07-06 | 2013-01-17 | The Parkinson's Institute | Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients |
AU2012296346A1 (en) | 2011-08-18 | 2014-04-03 | Biodelivery Sciences International, Inc. | Abuse-resistant mucoadhesive devices for delivery of buprenorphine |
EP2753380B1 (en) | 2011-09-05 | 2020-05-06 | Roche Diabetes Care GmbH | Hand-held injection device and disposable module |
US20130123719A1 (en) | 2011-11-12 | 2013-05-16 | Robert Bosch Gmbh | Medication compliance patch and control unit |
US20130184641A1 (en) | 2011-11-18 | 2013-07-18 | MiniPumps,LLC. | Accurate flow control in drug pump devices |
SG11201403162XA (en) | 2011-12-12 | 2014-10-30 | Lohmann Therapie Syst Lts | Transdermal delivery system comprising buprenorphine |
WO2013093666A1 (en) | 2011-12-20 | 2013-06-27 | Koninklijke Philips Electronics N.V. | A method and system for managing feedback to a user |
EP2794793B1 (en) | 2011-12-21 | 2018-11-28 | 3M Innovative Properties Company | Adhesive patch assembly with overlay liner and system and method for making same |
WO2013126557A2 (en) | 2012-02-22 | 2013-08-29 | Mgoodlife, Corp. | Personalization platform for behavioral change |
EP2847749A1 (en) | 2012-05-09 | 2015-03-18 | Koninklijke Philips N.V. | Device and method for supporting a behavior change of a person |
US20130311917A1 (en) | 2012-05-18 | 2013-11-21 | Gal Bar-or | Adaptive interactive media server and behavior change engine |
US9763592B2 (en) | 2012-05-25 | 2017-09-19 | Emotiv, Inc. | System and method for instructing a behavior change in a user |
US9408567B2 (en) | 2012-06-08 | 2016-08-09 | Medtronic Minimed, Inc. | Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods |
WO2014001877A1 (en) | 2012-06-25 | 2014-01-03 | Elevate Technologies Pty Ltd | A method for habit-making towards achieving a goal |
US9333292B2 (en) | 2012-06-26 | 2016-05-10 | Medtronic Minimed, Inc. | Mechanically actuated fluid infusion device |
US9044582B2 (en) | 2012-06-26 | 2015-06-02 | Franklin J. Chang | Apparatus and method for transdermal fluid delivery |
CA3080730C (en) * | 2012-08-13 | 2023-08-08 | Tg Medwise Ltd. | Substance delivery device |
US9962698B2 (en) | 2012-09-05 | 2018-05-08 | President And Fellows Of Harvard College | Removing bubbles in microfluidic systems |
WO2014043495A1 (en) | 2012-09-14 | 2014-03-20 | Wicka James C | Health management system |
US9111085B1 (en) | 2012-09-21 | 2015-08-18 | Girling Kelly Design Group, LLC | Computer-implemented system and method for electronic personal identity verification |
WO2014047638A1 (en) | 2012-09-24 | 2014-03-27 | Minipumps, Llc | Drug-delivery pump with intelligent control |
WO2014051128A1 (en) | 2012-09-28 | 2014-04-03 | 株式会社 ケイ・エム トランスダーム | Transdermal patch |
US20140099614A1 (en) | 2012-10-08 | 2014-04-10 | Lark Technologies, Inc. | Method for delivering behavior change directives to a user |
WO2014070254A1 (en) | 2012-11-01 | 2014-05-08 | Blue Spark Technologies, Inc. | Body temperature logging patch |
US20140163521A1 (en) | 2012-12-12 | 2014-06-12 | Animas Corporation | Medical infusion pump mechanism |
US9210566B2 (en) | 2013-01-18 | 2015-12-08 | Apple Inc. | Method and apparatus for automatically adjusting the operation of notifications based on changes in physical activity level |
US20140207047A1 (en) | 2013-01-22 | 2014-07-24 | Chrono Therapeutics, Inc. | Transdermal drug delivery system and method |
US10105487B2 (en) | 2013-01-24 | 2018-10-23 | Chrono Therapeutics Inc. | Optimized bio-synchronous bioactive agent delivery system |
US20140240124A1 (en) | 2013-02-25 | 2014-08-28 | Exmovere Wireless LLC | Method and apparatus for monitoring, determining and communicating biometric statuses, emotional states and movement |
US20160030412A1 (en) | 2013-02-26 | 2016-02-04 | Ari AZHIR | Compositions and methods for treatment in parkinson's disease patients |
US10772522B2 (en) | 2013-03-12 | 2020-09-15 | Vital Connect, Inc. | Disposable biometric patch device |
US10448849B2 (en) | 2013-03-15 | 2019-10-22 | Vital Connect, Inc. | Contextual heart rate monitoring |
US20140272846A1 (en) | 2013-03-15 | 2014-09-18 | Health Fitness Corporation | Systems and methods for altering an individual's behavior |
US9710761B2 (en) | 2013-03-15 | 2017-07-18 | Nordic Technology Group, Inc. | Method and apparatus for detection and prediction of events based on changes in behavior |
US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
US20140272844A1 (en) | 2013-03-15 | 2014-09-18 | Koninklijke Philips N.V. | Method for increasing the likelihood to induce behavior change in a lifestyle management program |
CA2846907C (en) | 2013-03-15 | 2018-02-27 | Michael E. Ingle | Device and method for self-limiting access to objects and substances |
US20140272845A1 (en) | 2013-03-15 | 2014-09-18 | Koninklijke Philips N.V. | Method for increasing the likelihood to induce behavior change in a lifestyle management program |
US9373269B2 (en) | 2013-03-18 | 2016-06-21 | Lifescan Scotland Limited | Patch pump training device |
US9672472B2 (en) | 2013-06-07 | 2017-06-06 | Mobiquity Incorporated | System and method for managing behavior change applications for mobile users |
EP2815778B1 (en) | 2013-06-21 | 2017-08-16 | F. Hoffmann-La Roche AG | Portable infusion device for infants with refillable small volume dosing unit |
EP3016586B1 (en) | 2013-07-01 | 2020-06-17 | Mayo Foundation for Medical Education and Research | Advanced health monitoring system |
US9538564B2 (en) | 2013-09-05 | 2017-01-03 | Intel Corporation | Techniques for wireless communication between a terminal computing device and a wearable computing device |
US9555277B2 (en) | 2013-09-18 | 2017-01-31 | Preventive Medical Health Care Co., Ltd. | Exercise equipment |
MX363492B (en) | 2013-09-19 | 2019-03-26 | Unaliwear Inc | Assist device and system. |
JP5550775B1 (en) | 2013-10-01 | 2014-07-16 | 合同会社Syndeo | Encapsulant delivery device |
US10556059B2 (en) | 2013-12-31 | 2020-02-11 | Biogen Ma Inc. | Infusion pump drive with compression spring |
US20170007550A1 (en) | 2014-01-22 | 2017-01-12 | 4P Therapeutics | Abuse and misuse deterrent transdermal systems |
GB2525150A (en) | 2014-01-30 | 2015-10-21 | Cellnovo Ltd | Therapeutic product delivery device |
WO2015123012A1 (en) | 2014-02-11 | 2015-08-20 | Smiths Medical Asd, Inc. | Pump startup algorithms and related systems and methods |
US9949935B2 (en) | 2014-04-08 | 2018-04-24 | Teikoku Pharma Usa, Inc. | Rivastigmine transdermal compositions and methods of using the same |
US20150310760A1 (en) | 2014-04-24 | 2015-10-29 | Mobilify Technology, Inc. | System and method for smoking cessation |
CA2948219C (en) | 2014-05-20 | 2023-04-04 | Lts Lohmann Therapie-Systeme Ag | Method for adjusting the release of active agent in a transdermal delivery system |
US11607026B2 (en) | 2014-05-30 | 2023-03-21 | Johnson & Johnson Consumer Inc. | Device for delivery of skin care composition |
ES2785549T3 (en) | 2014-07-18 | 2020-10-07 | Buzzz Pharmaceuticals Ltd | Oxymorphone transdermal patch |
US9513666B2 (en) | 2014-07-25 | 2016-12-06 | VivaLnk, Inc. | Highly compliant wearable wireless patch having stress-relief capability |
US9919096B2 (en) | 2014-08-26 | 2018-03-20 | Bigfoot Biomedical, Inc. | Infusion pump system and method |
US9993203B2 (en) | 2014-09-05 | 2018-06-12 | VivaLnk, Inc. | Electronic stickers with modular structures |
US9623017B2 (en) | 2014-09-24 | 2017-04-18 | Pain Therapeutics, Inc. | 4:3 naltrexone: 5-methyl-2-furaldehyde cocrystal |
EP3206569A2 (en) | 2014-10-15 | 2017-08-23 | Eccrine Systems, Inc. | Sweat sensing device communication security and compliance |
US20160317057A1 (en) | 2014-10-22 | 2016-11-03 | VivaLnk, Inc. | Compliant wearable patch capable of measuring electrical signals |
US20170249433A1 (en) | 2014-10-25 | 2017-08-31 | Sumner Bluffs, Llc. | Pharmaceutical and biological agent delivery system having biometric data acquisition and monitoring capabilities |
EP3219344B1 (en) | 2014-11-11 | 2021-05-05 | Terumo Kabushiki Kaisha | Drug-solution administration device |
WO2016081616A2 (en) | 2014-11-18 | 2016-05-26 | 4P Therapeutics | Transdermal patch formulations for delivery of water soluble drugs, peptides, proteins and oligosaccharides |
US9380698B1 (en) | 2014-12-05 | 2016-06-28 | VivaLnk, Inc. | Stretchable electronic patch having a foldable circuit layer |
US10642960B2 (en) | 2014-12-22 | 2020-05-05 | Koninklijke Philips N.V. | Wearable kit with smart patch |
US9693689B2 (en) | 2014-12-31 | 2017-07-04 | Blue Spark Technologies, Inc. | Body temperature logging patch |
US9656441B2 (en) | 2015-01-08 | 2017-05-23 | Alfred E. Tiefenbacher ( Gmbh & Co. Kg) | Transdermal patch |
KR102565565B1 (en) | 2015-02-06 | 2023-08-09 | 노벤 파머수티컬즈, 인코퍼레이티드 | Pressure-sensitive adhesives for transdermal drug delivery |
US10004887B2 (en) | 2015-02-18 | 2018-06-26 | Alma Therapeutics Ltd. | Transdermal delivery assembly |
WO2016145373A1 (en) | 2015-03-12 | 2016-09-15 | Chrono Therapeutics Inc. | Craving input and support system |
US20180075219A1 (en) | 2015-04-02 | 2018-03-15 | Click Therapeutics, Inc. | Therapeutic system and remote patient monitoring device |
US20160306936A1 (en) | 2015-04-15 | 2016-10-20 | Canon Kabushiki Kaisha | Diagnosis support system, information processing method, and program |
US11420047B2 (en) | 2015-05-08 | 2022-08-23 | Athena E. Ivanoff | Wireless patch system for transdermal, transmucosal and dental electrical drug delivery |
MX2017015586A (en) | 2015-06-01 | 2018-08-23 | Univ Illinois | Miniaturized electronic systems with wireless power and near-field communication capabilities. |
US9974492B1 (en) | 2015-06-05 | 2018-05-22 | Life365, Inc. | Health monitoring and communications device |
GB201511581D0 (en) | 2015-07-01 | 2015-08-12 | Chowdhury Dewan F H | Consumer wellbeing algorithm |
US9636457B2 (en) | 2015-07-19 | 2017-05-02 | Sanmina Corporation | System and method for a drug delivery and biosensor patch |
US10980799B2 (en) | 2015-09-24 | 2021-04-20 | Pain Therapeutics, Inc. | Crystalline salts of naloxone and naltrexone |
US10835499B2 (en) | 2015-12-30 | 2020-11-17 | Corium, Inc. | Systems and methods for long term transdermal administration |
GB201600920D0 (en) | 2016-01-18 | 2016-03-02 | Buzzz Pharmaceuticals Ltd | Transdermal patch |
US11039764B2 (en) | 2016-03-31 | 2021-06-22 | Zoll Medical Corporation | Biometric identification in medical devices |
US10292977B2 (en) | 2016-04-11 | 2019-05-21 | Neurocea, LLC | Compositions and methods for treatment related to fall and fall frequency in neurodegenerative diseases |
US10143687B2 (en) | 2016-04-11 | 2018-12-04 | Neurocea, LLC | Compositions and methods for treatment related to fall and fall frequency in neurodegenerative diseases |
US20180014783A1 (en) | 2016-07-13 | 2018-01-18 | VivaLnk, Inc. | Wearable patch having reliable conductive contacts for measuring electrical signals |
US9735893B1 (en) | 2016-07-21 | 2017-08-15 | Intel Corporation | Patch system for in-situ therapeutic treatment |
US10420473B2 (en) | 2016-07-29 | 2019-09-24 | VivaLnk, Inc. | Wearable thermometer patch for correct measurement of human skin temperature |
US20180028072A1 (en) | 2016-07-29 | 2018-02-01 | VivaLnk, Inc. | Wearable thermometer patch capable of measuring human skin temperature at high duty cycle |
US20180028071A1 (en) | 2016-07-29 | 2018-02-01 | VivaLnk Inc. | Wearable patch for measuring temperature and electrical signals |
US20180028069A1 (en) | 2016-07-29 | 2018-02-01 | VivaLnk Inc. | Wearable thermometer patch for accurate measurement of human skin temperature |
WO2018026759A1 (en) | 2016-08-03 | 2018-02-08 | Noven Pharmaceuticals, Inc. | Pressure-sensitive adhesives for transdermal drug delivery |
EP3518894A1 (en) | 2016-09-28 | 2019-08-07 | Chrono Therapeutics Inc. | Transdermal drug delivery device for delivering opioids |
US20180177455A1 (en) | 2016-11-27 | 2018-06-28 | Isvial Llc | Device and methods for monitoring or preventing misuse or abuse of analgesics |
US20190374482A1 (en) | 2016-12-05 | 2019-12-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
AU2018205529B2 (en) | 2017-01-06 | 2023-08-10 | Morningside Venture Investments Limited | Transdermal drug delivery devices and methods |
AU2018205252A1 (en) | 2017-01-06 | 2019-07-18 | Chrono Therapeutics Inc. | Methods and devices for treating Levodopa induced dyskinesia |
WO2019090125A2 (en) | 2017-11-02 | 2019-05-09 | Chrono Therapeutics Inc. | Smart abuse-deterrent transdermal drug delivery system |
JP7420797B2 (en) | 2018-05-29 | 2024-01-23 | モーニングサイド ベンチャー インベストメンツ リミテッド | Drug delivery methods and systems |
EP3880175A4 (en) | 2018-11-16 | 2022-08-17 | Morningside Venture Investments Limited | Thermally regulated transdermal drug delivery system |
-
2019
- 2019-05-29 JP JP2021517561A patent/JP7420797B2/en active Active
- 2019-05-29 EP EP19812316.8A patent/EP3801732A4/en active Pending
- 2019-05-29 US US17/057,318 patent/US11596779B2/en active Active
- 2019-05-29 WO PCT/US2019/034432 patent/WO2019232077A1/en unknown
- 2019-05-29 AU AU2019279884A patent/AU2019279884A1/en active Pending
- 2019-05-29 CA CA3101966A patent/CA3101966A1/en active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8252321B2 (en) * | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
US20060271020A1 (en) * | 2005-05-24 | 2006-11-30 | Huang Joseph Z | Portable drug delivery device including a detachable and replaceble administration or dosing element |
US9687186B2 (en) * | 2005-07-21 | 2017-06-27 | Steadymed Ltd. | Drug delivery device |
US20170157322A1 (en) * | 2009-12-30 | 2017-06-08 | Medtronic Minimed, Inc. | Connection and alignment detection systems and methods |
US20160220798A1 (en) | 2015-01-28 | 2016-08-04 | Zita S. Netzel | Drug delivery methods and systems |
US20160271020A1 (en) | 2015-03-19 | 2016-09-22 | Harry Coffey | Pacifier Holder |
WO2018148746A1 (en) * | 2017-02-13 | 2018-08-16 | Chrono Therapuetics Inc. | Transdermal drug delivery devices and methods |
Non-Patent Citations (1)
Title |
---|
See also references of EP3801732A4 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11596779B2 (en) | 2018-05-29 | 2023-03-07 | Morningside Venture Investments Limited | Drug delivery methods and systems |
WO2023272784A1 (en) * | 2021-01-05 | 2023-01-05 | Medtrum Technologies Inc. | A skin patch drug infusion device |
US12017029B2 (en) | 2023-03-03 | 2024-06-25 | Morningside Venture Investments Limited | Drug delivery methods and systems |
Also Published As
Publication number | Publication date |
---|---|
CA3101966A1 (en) | 2019-12-05 |
EP3801732A4 (en) | 2022-04-27 |
JP7420797B2 (en) | 2024-01-23 |
JP2021528208A (en) | 2021-10-21 |
US20240001095A1 (en) | 2024-01-04 |
AU2019279884A1 (en) | 2020-12-10 |
EP3801732A1 (en) | 2021-04-14 |
US11596779B2 (en) | 2023-03-07 |
US20210196935A1 (en) | 2021-07-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11596779B2 (en) | Drug delivery methods and systems | |
US11400266B2 (en) | Drug delivery methods and systems | |
AU2021204365B2 (en) | Method and device for vaporization and inhalation of isolated substances | |
AU736245B2 (en) | Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin | |
JP2022524277A (en) | Electronic breath-actuated droplet delivery system with dosage metering capability, inhalation topography method, and related usage | |
US20200030590A1 (en) | Transdermal drug delivery devices and methods | |
JP7413454B2 (en) | Method and device for vaporizing and inhaling isolated substances | |
EP3043860B1 (en) | System for controlling the iontophoretic delivery of therapeutic agents based on user inhalation | |
US12017029B2 (en) | Drug delivery methods and systems | |
EP3565637A1 (en) | Methods and devices for treating levodopa induced dyskinesia | |
US12011560B2 (en) | Drug delivery methods and systems |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 19812316 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 3101966 Country of ref document: CA |
|
ENP | Entry into the national phase |
Ref document number: 2021517561 Country of ref document: JP Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2019279884 Country of ref document: AU Date of ref document: 20190529 Kind code of ref document: A |
|
ENP | Entry into the national phase |
Ref document number: 2019812316 Country of ref document: EP Effective date: 20210111 |