WO2019227637A1 - Dispositif optique numérique utilisé pour modéliser la réticulation cornéenne - Google Patents

Dispositif optique numérique utilisé pour modéliser la réticulation cornéenne Download PDF

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Publication number
WO2019227637A1
WO2019227637A1 PCT/CN2018/096583 CN2018096583W WO2019227637A1 WO 2019227637 A1 WO2019227637 A1 WO 2019227637A1 CN 2018096583 W CN2018096583 W CN 2018096583W WO 2019227637 A1 WO2019227637 A1 WO 2019227637A1
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WO
WIPO (PCT)
Prior art keywords
ultraviolet light
projection
optical device
linking
micro
Prior art date
Application number
PCT/CN2018/096583
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English (en)
Chinese (zh)
Inventor
弥胜利
周一鸣
胡迎炳
杨帅涛
刘长勇
杜志昌
Original Assignee
清华大学深圳研究生院
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Application filed by 清华大学深圳研究生院 filed Critical 清华大学深圳研究生院
Publication of WO2019227637A1 publication Critical patent/WO2019227637A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A61N2005/0647—Applicators worn by the patient the applicator adapted to be worn on the head
    • A61N2005/0648—Applicators worn by the patient the applicator adapted to be worn on the head the light being directed to the eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0661—Radiation therapy using light characterised by the wavelength of light used ultraviolet

Definitions

  • the present invention relates to ophthalmic medical instruments, and in particular, to a digital optical device for patterned corneal cross-linking.
  • the cornea is a transparent tissue at the front end of the eyeball, and plays an important role in the optical system of the eyeball. Its refractive power accounts for more than half of the power of the eyeball refractive system, and slight changes in the shape of the cornea can cause large changes in vision.
  • Keratoconus is an eye disease in which the cornea is dilated and the center thins and protrudes to make the cornea conical. It changes the corneal shape in a wide range and causes a sharp decline in vision.
  • Myopia, hyperopia, and astigmatism are all eye diseases involving the refractive power of the eyeball system. By changing the refractive power of the cornea, the condition can be alleviated and the vision can be restored.
  • Corneal cross-linking is a treatment method for keratoconus disease. It uses the following reaction principle.
  • the photosensitizer applied on the surface of the cornea cross-links with the collagen fibers of the cornea under the irradiation of ultraviolet light, thereby improving the mechanical strength of the cornea. Relieves further deterioration of keratoconus disease.
  • the treatment methods of the existing corneal cross-linking instruments are still very rough. Most of the treatment instruments are limited in the controllability and accuracy of the optical system. They can only illuminate the entire range of the corneal center. A slightly better device can change the size of the irradiation spot. And the light intensity distribution along the radius can not meet the personalized treatment needs of patients with corneal disease.
  • the main purpose of the present invention is to overcome the deficiency of the optical system of the existing corneal cross-linking instrument that cannot meet the personalized treatment needs of patients with keratoconus, and provide a digital optical device for patterned corneal cross-linking, which flexibly meets the individualization. Treatment needs and significantly improve the treatment effect and efficiency of corneal cross-linking surgery.
  • the present invention adopts the following technical solutions:
  • a digital optical device for patterned corneal cross-linking includes an ultraviolet light source system and a collimation system, the ultraviolet light source system is used to provide stable ultraviolet light with adjustable power, and the collimation system is used to collimate an ultraviolet beam
  • the optical device further includes a beam modulation system, a projection lighting system, and a control system.
  • the beam modulation system includes a digitized light projection chip having a micro-mirror array, and the digitized light projection chip subdivides the collimated ultraviolet light beam.
  • the control system controls the deflection of each micro-mirror of the digital light projection chip in a predetermined manner to achieve the use of each corresponding small beam, and controls each micro-mirror
  • the ratio of the deflection time to the undeflected time per unit time that is, the duty cycle, to control the illumination energy of each small beam per unit time to generate irradiation with different predetermined intensity distributions corresponding to different predetermined areas.
  • the projection lighting system projects the modulated light beam to the illumination area to realize the range and energy of the corneal cross-linking area. Refinement and dynamic control of quantity distribution.
  • the uniform light system includes a microlens group and a mirror group, and the microlens group and the mirror group are used for collimation.
  • the UV beam is homogenized and then transmitted to the beam modulation system for modulation.
  • the collimation system includes a spherical reflector and a collimating lens group, and an ultraviolet beam is collected through the spherical reflector, and then the collimating lens group is used to collimate the ultraviolet beam.
  • the ultraviolet light source system includes an ultraviolet light source and a power source module.
  • the luminous power of the ultraviolet light source is not greater than 5 watts, and the emitted ultraviolet wavelength is 360 to 370 nm.
  • the power source module provides a continuously adjustable current of 0 to 5A.
  • the ultraviolet light source system further includes a curved reflector arranged around the light source for reflecting and condensing the ultraviolet light.
  • the projection lighting system is arranged so that its projection distance can be controlled by the control system.
  • the projection lighting system includes a lens group, and the relative positions of the lenses in the lens group can be set to be fine-tuned to control the range of the irradiation area.
  • the lens group of the projection lighting system is set so that the control system can adjust the relative position between the lenses to fine-tune the size of the projection image formed at a fixed projection distance.
  • the beam modulation system is set to achieve a control accuracy of 50 micrometers for the illumination image.
  • a digital optical device for patterning corneal cross-linking, for providing a corneal cross-linking illumination image includes an ultraviolet light source system and a collimation system, and the ultraviolet light source system is used for providing adjustable power stability Ultraviolet light, the collimation system is used to collimate ultraviolet light beams, the device further includes a beam modulation system, a projection lighting system, and a control system, the beam modulation system includes a digital light projection chip with a micro-mirror array, the The digital light projection chip subdivides the collimated ultraviolet light beam into a plurality of controllable small beams, and the control system controls the deflection of each micro-mirror of the digital light projection chip in a predetermined manner to achieve the corresponding
  • the optical device provided by the present invention has the ability to control the range and energy distribution of the corneal cross-linked area, can realize the refinement and dynamic control of the range and energy distribution of the corneal cross-linked area, can realize the generation of specific lighting images, and flexibly meet
  • Patients with keratoconus can be used for the treatment of myopia, hyperopia, astigmatism and other eye diseases related to the refractive power of the eyeball optical system. It can reduce the corneal irradiation area and corneal damage while achieving better treatment results, greatly improving
  • the treatment effect and efficiency of corneal cross-linking surgery provide research possibilities and superior experimental equipment for accurate corneal cross-linking mechanical modeling.
  • the present invention also provides an optical device for generating a specific illumination treatment pattern. Unlike the existing device which generates a circular light spot, the optical device of the present invention generates a specific star-shaped illumination treatment pattern, which reduces the cross-linking area and reduces In order to damage the cornea, it can achieve a good therapeutic effect and reach the set corneal strength.
  • the digital optical device for patterned corneal cross-linking of the present invention can also be used for experiments related to patterned corneal cross-linking, to explore the effect of corneal cross-linking on the overall mechanical properties of corneal tissue, and to realize the modeling of corneal cross-linking reactions. Eventually provide a good vision recovery program for specific corneal diseases.
  • FIG. 1 is a structural block diagram of a patterned corneal cross-linked digital optical device according to an embodiment of the present invention
  • FIG. 2 is a schematic diagram of an optical path of a patterned corneal cross-linked digital optical device according to an embodiment of the present invention
  • FIG. 3 is a corneal cross-linked illumination pattern generated by a patterned corneal cross-linked digital optical device according to an embodiment of the present invention
  • FIG. 4 shows several other corneal cross-linked illumination patterns generated by a patterned corneal cross-linked digital optical device according to an embodiment of the present invention.
  • a digital optical device for patterned corneal cross-linking includes an ultraviolet light source system and a collimation system 1, a beam modulation system 3, a projection lighting system 4, and a control system.
  • the ultraviolet light source system is used to provide stable ultraviolet light with adjustable power
  • the collimation system is used to collimate ultraviolet light beams
  • the beam modulation system 3 includes a digitized light projection chip having a micro-mirror array, the digitization The light projection chip subdivides the collimated ultraviolet beam into a plurality of controllable small beams, and the control system controls the deflection of each micro-mirror of the digital light projection chip in a predetermined manner to achieve the corresponding small beams.
  • the modulated light beam is projected onto the illuminated area by the projection lighting system 4 to achieve the cornea Fine and dynamic control of the domains and the range of energy distribution.
  • the optical device can realize the fine and dynamic control of the range and energy distribution of the corneal cross-linking, which greatly improves the treatment effect and efficiency of corneal cross-linking surgery, and provides research possibilities and precise research on the mechanical modeling of corneal cross-linking. Superior experimental equipment. Because the optical device has the ability to finely and dynamically control the range and energy distribution of the corneal cross-linking area, it can achieve a good therapeutic effect while reducing the corneal irradiation area and the corneal injury.
  • the optical device further includes a uniform light system 2 disposed between the collimation system and the beam modulation system 3.
  • the uniform light system 2 includes a micro lens group and a mirror group. The micro-lens group and the mirror group perform homogenization processing on the collimated ultraviolet light beam, and then transmit the homogenized ultraviolet light beam to the light beam modulation system 3 for modulation.
  • the collimation system includes a spherical mirror and a collimating lens group, and an ultraviolet beam is focused by the spherical mirror, and then the collimating lens group is used to collimate the ultraviolet beam.
  • the ultraviolet light source system includes an ultraviolet light source and a power module.
  • the ultraviolet light source has a luminous power of not more than 5 watts, and the emitted ultraviolet wavelength is 360 to 370 nm.
  • the power module provides 0 to 5A continuous power. Regulated current.
  • the ultraviolet light source system further includes a curved reflector disposed around the light source, for reflecting and condensing the ultraviolet light.
  • the projection lighting system 4 is configured to be capable of controlling its projection distance by the control system.
  • the projection lighting system 4 includes a lens group, and the relative position of each lens in the lens group is set to be fine-tunable to control the range of the irradiation area.
  • the lens group of the projection lighting system 4 is set so that the control system can adjust the relative position between the lenses to fine-tune the size of the projection image formed at a fixed projection distance.
  • the beam modulation system 3 is configured to achieve a control accuracy of 50 micrometers for the illumination image.
  • a digital optical device for patterning corneal cross-linking is used to provide a corneal cross-linking illumination image.
  • the device includes an ultraviolet light source system and a light source.
  • the deflection of each micro-mirror of the chip is used to achieve the use of each corresponding small beam, and the ratio of deflection time to undeflected time per unit time of each micro-mirror is controlled, that is, the duty cycle, to control each The illumination energy of
  • the modulated light beam is projected to the illumination area to achieve fine and dynamic control of the range and energy distribution of the corneal cross-linking area;
  • the corneal cross-linking illumination image includes a circle in the center and is uniform on the outer periphery of the circle Six rectangular columns spaced apart form a star shape that diverges outward from the center.
  • the optical device of the embodiment of the present invention generates a specific lighting treatment pattern in the shape of a star, which not only reduces the cross-linking area, reduces damage to the cornea, but also achieves a good therapeutic effect. To reach the set corneal strength.
  • the optical device further includes a uniform light system 2 disposed between the collimation system and the beam modulation system 3.
  • the uniform light system 2 includes a micro lens group and a mirror group. The micro-lens group and the mirror group perform homogenization processing on the collimated ultraviolet light beam, and then transmit the homogenized ultraviolet light beam to the light beam modulation system 3 for modulation.
  • the patterned corneal cross-linked digital optical device includes an ultraviolet light source system and a collimation system 1 and a uniform light system arranged along the optical path. 2. Beam modulation system 3, projection lighting system 4, and control system (not shown). In the ultraviolet light source system and the collimation system 1, near-ultraviolet light having a wavelength of 360 to 370 is emitted by a light emitting diode, and then is reflected and converged by a curved mirror around the light source, and then the light is collimated through a collimating lens group 2.
  • the control system changes the direction of each mirror in the micro-mirror array, and it will deflect the tiny beams that do not need to be retained (the deflected beams can be absorbed using additional energy absorption devices), The light beam still propagates according to the original path; on the other hand, the ratio of the deflection time to the undeflected time per unit time of each mirror in the beam modulation system 3 is controlled, that is, the duty cycle.
  • the relative position between the lenses can be adjusted to fine-tune the size of the projected image at a fixed projection distance.
  • FIG. 3 and FIG. 4 are examples of several corneal cross-linked illumination patterns generated by a digitalized optical device for patterned corneal cross-linking according to an embodiment of the present invention.

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  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
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Abstract

Un dispositif optique numérique utilisé pour modéliser une réticulation cornéenne, comprenant un système de source de lumière ultraviolette et un système de collimation (1), un système de modulation de faisceau de lumière (3), un système d'éclairage de projection (4) et un système de commande; le système de modulation de faisceau de lumière (3) comprend une puce de projection de lumière numérique qui est pourvue d'un réseau de micro-réflecteurs, la puce de projection de lumière numérique subdivisant un faisceau de lumière ultraviolette collimaté en une pluralité de petits faisceaux de lumière pouvant être commandés; le système de commande commande la déviation ou sinon de chaque micro-réflecteur de la puce de projection de lumière numérique selon une manière prédéterminée, et commande le rapport de temps de déviation à un temps de non déviation par unité de temps de chaque micro-réflecteur de façon à commander l'énergie d'éclairage par unité de temps de chaque petit faisceau de lumière, générant ainsi un éclairage ayant différentes distributions d'intensité prédéterminées correspondant à différentes régions prédéterminées, ce qui permet d'obtenir une commande affinée et dynamique de la plage et de la distribution d'énergie d'une région de réticulation cornéenne. Le dispositif peut répondre avec souplesse aux besoins d'un traitement personnalisé de la cornée et améliorer significativement l'effet thérapeutique et l'efficacité de la chirurgie de réticulation cornéenne.
PCT/CN2018/096583 2018-05-29 2018-07-23 Dispositif optique numérique utilisé pour modéliser la réticulation cornéenne WO2019227637A1 (fr)

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CN201810533913.8A CN108744293B (zh) 2018-05-29 2018-05-29 一种用于图像化角膜交联的数字化光学装置
CN201810533913.8 2018-05-29

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CN110417097A (zh) * 2019-08-28 2019-11-05 中国科学院半导体研究所 具有消毒功能的便携式充电装置及应用
CN112316312A (zh) * 2020-11-02 2021-02-05 深圳市定视生物医疗科技有限公司 一种角膜交联仪

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CN105498097A (zh) * 2015-12-23 2016-04-20 济南三维医疗器械有限公司 一种角膜交联仪
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