WO2019227637A1 - Digital optical device used for patterning corneal cross-linking - Google Patents
Digital optical device used for patterning corneal cross-linking Download PDFInfo
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- WO2019227637A1 WO2019227637A1 PCT/CN2018/096583 CN2018096583W WO2019227637A1 WO 2019227637 A1 WO2019227637 A1 WO 2019227637A1 CN 2018096583 W CN2018096583 W CN 2018096583W WO 2019227637 A1 WO2019227637 A1 WO 2019227637A1
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- 230000003287 optical effect Effects 0.000 title claims abstract description 42
- 238000004132 cross linking Methods 0.000 title claims abstract description 40
- 238000000059 patterning Methods 0.000 title claims abstract description 5
- 238000005286 illumination Methods 0.000 claims abstract description 29
- 238000009826 distribution Methods 0.000 claims abstract description 19
- 210000004087 cornea Anatomy 0.000 abstract description 13
- 238000011282 treatment Methods 0.000 abstract description 12
- 238000001356 surgical procedure Methods 0.000 abstract description 4
- 230000001225 therapeutic effect Effects 0.000 abstract description 4
- 201000002287 Keratoconus Diseases 0.000 description 5
- 210000005252 bulbus oculi Anatomy 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 230000004438 eyesight Effects 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 208000030533 eye disease Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000011269 treatment regimen Methods 0.000 description 3
- 208000028006 Corneal injury Diseases 0.000 description 2
- 206010020675 Hypermetropia Diseases 0.000 description 2
- 201000009310 astigmatism Diseases 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 208000021921 corneal disease Diseases 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- 201000006318 hyperopia Diseases 0.000 description 2
- 230000004305 hyperopia Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 208000001491 myopia Diseases 0.000 description 2
- 230000004379 myopia Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0645—Applicators worn by the patient
- A61N2005/0647—Applicators worn by the patient the applicator adapted to be worn on the head
- A61N2005/0648—Applicators worn by the patient the applicator adapted to be worn on the head the light being directed to the eyes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0661—Radiation therapy using light characterised by the wavelength of light used ultraviolet
Definitions
- the present invention relates to ophthalmic medical instruments, and in particular, to a digital optical device for patterned corneal cross-linking.
- the cornea is a transparent tissue at the front end of the eyeball, and plays an important role in the optical system of the eyeball. Its refractive power accounts for more than half of the power of the eyeball refractive system, and slight changes in the shape of the cornea can cause large changes in vision.
- Keratoconus is an eye disease in which the cornea is dilated and the center thins and protrudes to make the cornea conical. It changes the corneal shape in a wide range and causes a sharp decline in vision.
- Myopia, hyperopia, and astigmatism are all eye diseases involving the refractive power of the eyeball system. By changing the refractive power of the cornea, the condition can be alleviated and the vision can be restored.
- Corneal cross-linking is a treatment method for keratoconus disease. It uses the following reaction principle.
- the photosensitizer applied on the surface of the cornea cross-links with the collagen fibers of the cornea under the irradiation of ultraviolet light, thereby improving the mechanical strength of the cornea. Relieves further deterioration of keratoconus disease.
- the treatment methods of the existing corneal cross-linking instruments are still very rough. Most of the treatment instruments are limited in the controllability and accuracy of the optical system. They can only illuminate the entire range of the corneal center. A slightly better device can change the size of the irradiation spot. And the light intensity distribution along the radius can not meet the personalized treatment needs of patients with corneal disease.
- the main purpose of the present invention is to overcome the deficiency of the optical system of the existing corneal cross-linking instrument that cannot meet the personalized treatment needs of patients with keratoconus, and provide a digital optical device for patterned corneal cross-linking, which flexibly meets the individualization. Treatment needs and significantly improve the treatment effect and efficiency of corneal cross-linking surgery.
- the present invention adopts the following technical solutions:
- a digital optical device for patterned corneal cross-linking includes an ultraviolet light source system and a collimation system, the ultraviolet light source system is used to provide stable ultraviolet light with adjustable power, and the collimation system is used to collimate an ultraviolet beam
- the optical device further includes a beam modulation system, a projection lighting system, and a control system.
- the beam modulation system includes a digitized light projection chip having a micro-mirror array, and the digitized light projection chip subdivides the collimated ultraviolet light beam.
- the control system controls the deflection of each micro-mirror of the digital light projection chip in a predetermined manner to achieve the use of each corresponding small beam, and controls each micro-mirror
- the ratio of the deflection time to the undeflected time per unit time that is, the duty cycle, to control the illumination energy of each small beam per unit time to generate irradiation with different predetermined intensity distributions corresponding to different predetermined areas.
- the projection lighting system projects the modulated light beam to the illumination area to realize the range and energy of the corneal cross-linking area. Refinement and dynamic control of quantity distribution.
- the uniform light system includes a microlens group and a mirror group, and the microlens group and the mirror group are used for collimation.
- the UV beam is homogenized and then transmitted to the beam modulation system for modulation.
- the collimation system includes a spherical reflector and a collimating lens group, and an ultraviolet beam is collected through the spherical reflector, and then the collimating lens group is used to collimate the ultraviolet beam.
- the ultraviolet light source system includes an ultraviolet light source and a power source module.
- the luminous power of the ultraviolet light source is not greater than 5 watts, and the emitted ultraviolet wavelength is 360 to 370 nm.
- the power source module provides a continuously adjustable current of 0 to 5A.
- the ultraviolet light source system further includes a curved reflector arranged around the light source for reflecting and condensing the ultraviolet light.
- the projection lighting system is arranged so that its projection distance can be controlled by the control system.
- the projection lighting system includes a lens group, and the relative positions of the lenses in the lens group can be set to be fine-tuned to control the range of the irradiation area.
- the lens group of the projection lighting system is set so that the control system can adjust the relative position between the lenses to fine-tune the size of the projection image formed at a fixed projection distance.
- the beam modulation system is set to achieve a control accuracy of 50 micrometers for the illumination image.
- a digital optical device for patterning corneal cross-linking, for providing a corneal cross-linking illumination image includes an ultraviolet light source system and a collimation system, and the ultraviolet light source system is used for providing adjustable power stability Ultraviolet light, the collimation system is used to collimate ultraviolet light beams, the device further includes a beam modulation system, a projection lighting system, and a control system, the beam modulation system includes a digital light projection chip with a micro-mirror array, the The digital light projection chip subdivides the collimated ultraviolet light beam into a plurality of controllable small beams, and the control system controls the deflection of each micro-mirror of the digital light projection chip in a predetermined manner to achieve the corresponding
- the optical device provided by the present invention has the ability to control the range and energy distribution of the corneal cross-linked area, can realize the refinement and dynamic control of the range and energy distribution of the corneal cross-linked area, can realize the generation of specific lighting images, and flexibly meet
- Patients with keratoconus can be used for the treatment of myopia, hyperopia, astigmatism and other eye diseases related to the refractive power of the eyeball optical system. It can reduce the corneal irradiation area and corneal damage while achieving better treatment results, greatly improving
- the treatment effect and efficiency of corneal cross-linking surgery provide research possibilities and superior experimental equipment for accurate corneal cross-linking mechanical modeling.
- the present invention also provides an optical device for generating a specific illumination treatment pattern. Unlike the existing device which generates a circular light spot, the optical device of the present invention generates a specific star-shaped illumination treatment pattern, which reduces the cross-linking area and reduces In order to damage the cornea, it can achieve a good therapeutic effect and reach the set corneal strength.
- the digital optical device for patterned corneal cross-linking of the present invention can also be used for experiments related to patterned corneal cross-linking, to explore the effect of corneal cross-linking on the overall mechanical properties of corneal tissue, and to realize the modeling of corneal cross-linking reactions. Eventually provide a good vision recovery program for specific corneal diseases.
- FIG. 1 is a structural block diagram of a patterned corneal cross-linked digital optical device according to an embodiment of the present invention
- FIG. 2 is a schematic diagram of an optical path of a patterned corneal cross-linked digital optical device according to an embodiment of the present invention
- FIG. 3 is a corneal cross-linked illumination pattern generated by a patterned corneal cross-linked digital optical device according to an embodiment of the present invention
- FIG. 4 shows several other corneal cross-linked illumination patterns generated by a patterned corneal cross-linked digital optical device according to an embodiment of the present invention.
- a digital optical device for patterned corneal cross-linking includes an ultraviolet light source system and a collimation system 1, a beam modulation system 3, a projection lighting system 4, and a control system.
- the ultraviolet light source system is used to provide stable ultraviolet light with adjustable power
- the collimation system is used to collimate ultraviolet light beams
- the beam modulation system 3 includes a digitized light projection chip having a micro-mirror array, the digitization The light projection chip subdivides the collimated ultraviolet beam into a plurality of controllable small beams, and the control system controls the deflection of each micro-mirror of the digital light projection chip in a predetermined manner to achieve the corresponding small beams.
- the modulated light beam is projected onto the illuminated area by the projection lighting system 4 to achieve the cornea Fine and dynamic control of the domains and the range of energy distribution.
- the optical device can realize the fine and dynamic control of the range and energy distribution of the corneal cross-linking, which greatly improves the treatment effect and efficiency of corneal cross-linking surgery, and provides research possibilities and precise research on the mechanical modeling of corneal cross-linking. Superior experimental equipment. Because the optical device has the ability to finely and dynamically control the range and energy distribution of the corneal cross-linking area, it can achieve a good therapeutic effect while reducing the corneal irradiation area and the corneal injury.
- the optical device further includes a uniform light system 2 disposed between the collimation system and the beam modulation system 3.
- the uniform light system 2 includes a micro lens group and a mirror group. The micro-lens group and the mirror group perform homogenization processing on the collimated ultraviolet light beam, and then transmit the homogenized ultraviolet light beam to the light beam modulation system 3 for modulation.
- the collimation system includes a spherical mirror and a collimating lens group, and an ultraviolet beam is focused by the spherical mirror, and then the collimating lens group is used to collimate the ultraviolet beam.
- the ultraviolet light source system includes an ultraviolet light source and a power module.
- the ultraviolet light source has a luminous power of not more than 5 watts, and the emitted ultraviolet wavelength is 360 to 370 nm.
- the power module provides 0 to 5A continuous power. Regulated current.
- the ultraviolet light source system further includes a curved reflector disposed around the light source, for reflecting and condensing the ultraviolet light.
- the projection lighting system 4 is configured to be capable of controlling its projection distance by the control system.
- the projection lighting system 4 includes a lens group, and the relative position of each lens in the lens group is set to be fine-tunable to control the range of the irradiation area.
- the lens group of the projection lighting system 4 is set so that the control system can adjust the relative position between the lenses to fine-tune the size of the projection image formed at a fixed projection distance.
- the beam modulation system 3 is configured to achieve a control accuracy of 50 micrometers for the illumination image.
- a digital optical device for patterning corneal cross-linking is used to provide a corneal cross-linking illumination image.
- the device includes an ultraviolet light source system and a light source.
- the deflection of each micro-mirror of the chip is used to achieve the use of each corresponding small beam, and the ratio of deflection time to undeflected time per unit time of each micro-mirror is controlled, that is, the duty cycle, to control each The illumination energy of
- the modulated light beam is projected to the illumination area to achieve fine and dynamic control of the range and energy distribution of the corneal cross-linking area;
- the corneal cross-linking illumination image includes a circle in the center and is uniform on the outer periphery of the circle Six rectangular columns spaced apart form a star shape that diverges outward from the center.
- the optical device of the embodiment of the present invention generates a specific lighting treatment pattern in the shape of a star, which not only reduces the cross-linking area, reduces damage to the cornea, but also achieves a good therapeutic effect. To reach the set corneal strength.
- the optical device further includes a uniform light system 2 disposed between the collimation system and the beam modulation system 3.
- the uniform light system 2 includes a micro lens group and a mirror group. The micro-lens group and the mirror group perform homogenization processing on the collimated ultraviolet light beam, and then transmit the homogenized ultraviolet light beam to the light beam modulation system 3 for modulation.
- the patterned corneal cross-linked digital optical device includes an ultraviolet light source system and a collimation system 1 and a uniform light system arranged along the optical path. 2. Beam modulation system 3, projection lighting system 4, and control system (not shown). In the ultraviolet light source system and the collimation system 1, near-ultraviolet light having a wavelength of 360 to 370 is emitted by a light emitting diode, and then is reflected and converged by a curved mirror around the light source, and then the light is collimated through a collimating lens group 2.
- the control system changes the direction of each mirror in the micro-mirror array, and it will deflect the tiny beams that do not need to be retained (the deflected beams can be absorbed using additional energy absorption devices), The light beam still propagates according to the original path; on the other hand, the ratio of the deflection time to the undeflected time per unit time of each mirror in the beam modulation system 3 is controlled, that is, the duty cycle.
- the relative position between the lenses can be adjusted to fine-tune the size of the projected image at a fixed projection distance.
- FIG. 3 and FIG. 4 are examples of several corneal cross-linked illumination patterns generated by a digitalized optical device for patterned corneal cross-linking according to an embodiment of the present invention.
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Abstract
A digital optical device used for patterning corneal cross-linking, comprising an ultraviolet light source system and a collimation system (1), a light beam modulation system (3), a projection illumination system (4) and a control system; the light beam modulation system (3) comprises a digital light projection chip that is provided with a micro-reflector array, the digital light projection chip subdividing a collimated ultraviolet light beam into a plurality of controllable small light beams; the control system controls the deflection or otherwise of each micro-reflector of the digital light projection chip according to a predetermined manner, and controls the ratio of deflection time to non-deflection time per unit time of each micro-reflector so as to control the illumination energy per unit time of each small light beam, thus generating illumination having different predetermined intensity distributions corresponding to different predetermined regions, thereby achieving refined and dynamic control of the range and energy distribution of a corneal cross-linking region. The device may flexibly meet the needs for personalized treatment of the cornea and significantly improve the therapeutic effect and efficiency of corneal cross-linking surgery.
Description
本发明涉及眼科医疗器械，特别是涉及一种用于图案化角膜交联的数字化光学装置。The present invention relates to ophthalmic medical instruments, and in particular, to a digital optical device for patterned corneal cross-linking.
角膜是眼球前端的透明组织，在眼球光学系统中起到重要作用，其屈光能力占眼球屈光系统能力的一半以上，角膜形状的轻微变化会引起视力的大幅度改变。圆锥角膜是一种以角膜扩张、中央变薄向前突出使角膜呈现圆锥形状的眼部疾病，大范围的改变了角膜形状，会造成了视力的急剧下降。近视、远视和散光，都是涉及眼球系统屈光能力的眼科疾病，通过改变角膜的屈光能力能对病情进行缓解，起到恢复视力的效果。The cornea is a transparent tissue at the front end of the eyeball, and plays an important role in the optical system of the eyeball. Its refractive power accounts for more than half of the power of the eyeball refractive system, and slight changes in the shape of the cornea can cause large changes in vision. Keratoconus is an eye disease in which the cornea is dilated and the center thins and protrudes to make the cornea conical. It changes the corneal shape in a wide range and causes a sharp decline in vision. Myopia, hyperopia, and astigmatism are all eye diseases involving the refractive power of the eyeball system. By changing the refractive power of the cornea, the condition can be alleviated and the vision can be restored.
角膜交联是一种圆锥角膜疾病的治疗手段，它利用以下的反应原理，涂抹在角膜表面的光敏剂在紫外光的照射下，与角膜胶原纤维发生交联反应，从而提高角膜力学强度，进而缓解圆锥角膜疾病的进一步恶化。Corneal cross-linking is a treatment method for keratoconus disease. It uses the following reaction principle. The photosensitizer applied on the surface of the cornea cross-links with the collagen fibers of the cornea under the irradiation of ultraviolet light, thereby improving the mechanical strength of the cornea. Relieves further deterioration of keratoconus disease.
现有角膜交联仪器的治疗方法还很粗糙，大部分治疗仪器限于光学系统的可控制性和精度不够，只能对角膜中心位置进行全范围的照明，稍好一点的装置可以改变照射光斑大小和沿半径的光强分布，远远满足不了角膜疾病患者个性化的治疗需求。The treatment methods of the existing corneal cross-linking instruments are still very rough. Most of the treatment instruments are limited in the controllability and accuracy of the optical system. They can only illuminate the entire range of the corneal center. A slightly better device can change the size of the irradiation spot. And the light intensity distribution along the radius can not meet the personalized treatment needs of patients with corneal disease.
发明内容Summary of the Invention
本发明的主要目的在于克服现有角膜交联仪器的光学系统不能很好地满足圆锥角膜患者个性化治疗需求的不足，提供一种用于图案化角膜交联的数字化光学装置，灵活满足个性化治疗需求并显著提高角膜交联手术的治疗效果和效率。The main purpose of the present invention is to overcome the deficiency of the optical system of the existing corneal cross-linking instrument that cannot meet the personalized treatment needs of patients with keratoconus, and provide a digital optical device for patterned corneal cross-linking, which flexibly meets the individualization. Treatment needs and significantly improve the treatment effect and efficiency of corneal cross-linking surgery.
为实现上述目的，本发明采用以下技术方案：To achieve the above objective, the present invention adopts the following technical solutions:
一种用于图案化角膜交联的数字化光学装置，包括紫外光源系统和准直系统，所述紫外光源系统用于提供功率可调的稳定紫外光，所述准直系统用于准直紫外光束，所述光学装置还包括光束调制系统、投影照明系统和控制系统，所述光束调制系统包括具有微反射镜阵列的数字化光投影芯片，所述数字化光投影芯片将经准直的紫外光束细分为多个可控小光束，所述控制系统按照预定的方式控制所述数字化光投影芯片各个微反射镜的 偏转与否来达到对各个相应的小光束的使用与否，并控制各个微反射镜的每单位时间内偏转时间与未偏转时间的比值，即空占比，以控制各个小光束每单位时间内的照明能量，来产生对应于不同的预定区域具有不同的预定强度分布的照射，通过所述投影照明系统将已调制光束投射到照明区域，以实现对角膜交联区域范围和能量分布的精细化和动态控制。A digital optical device for patterned corneal cross-linking includes an ultraviolet light source system and a collimation system, the ultraviolet light source system is used to provide stable ultraviolet light with adjustable power, and the collimation system is used to collimate an ultraviolet beam The optical device further includes a beam modulation system, a projection lighting system, and a control system. The beam modulation system includes a digitized light projection chip having a micro-mirror array, and the digitized light projection chip subdivides the collimated ultraviolet light beam. For a plurality of controllable small beams, the control system controls the deflection of each micro-mirror of the digital light projection chip in a predetermined manner to achieve the use of each corresponding small beam, and controls each micro-mirror The ratio of the deflection time to the undeflected time per unit time, that is, the duty cycle, to control the illumination energy of each small beam per unit time to generate irradiation with different predetermined intensity distributions corresponding to different predetermined areas. The projection lighting system projects the modulated light beam to the illumination area to realize the range and energy of the corneal cross-linking area. Refinement and dynamic control of quantity distribution.
进一步地：further:
还包括设置于所述准直系统和所述光束调制系统之间的匀光系统，所述匀光系统包括微透镜组和反射镜组，通过所述微透镜组与反射镜组对经准直的紫外光束进行均匀化处理再传送至所述光束调制系统进行调制。It also includes a uniform light system arranged between the collimation system and the beam modulation system. The uniform light system includes a microlens group and a mirror group, and the microlens group and the mirror group are used for collimation. The UV beam is homogenized and then transmitted to the beam modulation system for modulation.
所述准直系统包括球面反射镜和准直透镜组，通过所述球面反射镜汇聚紫外光束，再利用所述准直透镜组对紫外光束进行准直。The collimation system includes a spherical reflector and a collimating lens group, and an ultraviolet beam is collected through the spherical reflector, and then the collimating lens group is used to collimate the ultraviolet beam.
所述紫外光源系统包括紫外光源和电源模块，所述紫外光源的发光功率不大于5瓦，发射的紫外线波长为360至370nm，所述电源模块提供0至5A连续可调的电流。The ultraviolet light source system includes an ultraviolet light source and a power source module. The luminous power of the ultraviolet light source is not greater than 5 watts, and the emitted ultraviolet wavelength is 360 to 370 nm. The power source module provides a continuously adjustable current of 0 to 5A.
所述紫外光源系统还包括设置在光源周围的曲面反射镜，用于对紫外光进行反射汇聚。The ultraviolet light source system further includes a curved reflector arranged around the light source for reflecting and condensing the ultraviolet light.
所述投影照明系统经设置能够由所述控制系统控制其投影距离。The projection lighting system is arranged so that its projection distance can be controlled by the control system.
所述投影照明系统包括透镜组，该透镜组中各透镜的相对位置经设置可微调以实现对照射区域范围的控制。The projection lighting system includes a lens group, and the relative positions of the lenses in the lens group can be set to be fine-tuned to control the range of the irradiation area.
所述投影照明系统的透镜组经设置使得所述控制系统能够对透镜间的相对位置进行调整来微调在固定的投影距离上形成的投影图像的大小。The lens group of the projection lighting system is set so that the control system can adjust the relative position between the lenses to fine-tune the size of the projection image formed at a fixed projection distance.
所述光束调制系统经设置以使对于照明图像达到50微米的控制精度。The beam modulation system is set to achieve a control accuracy of 50 micrometers for the illumination image.
一种用于图案化角膜交联的数字化光学装置，用于提供一种角膜交联照明图像，所述装置包括紫外光源系统和准直系统，所述紫外光源系统用于提供功率可调的稳定紫外光，所述准直系统用于准直紫外光束，所述装置还包括光束调制系统、投影照明系统和控制系统，所述光束调制系统包括具有微反射镜阵列的数字化光投影芯片，所述数字化光投影芯片将经准直的紫外光束细分为多个可控小光束，所述控制系统按照预定的方式控制所述数字化光投影芯片各个微反射镜的偏转与否来达到对各个相应的小光束的使用与否，并控制各个微反射镜的每单位时间内偏转时间与未偏转时间的比值，即空占比，以控制各个小光束每单位时间内的照明能量，来产生对应于不同的预定区域具有不同的预定强度分布的照射，通过所述投影照明系统将已调制光束投射到照明区域，以实现对角膜交联区域范围和能 量分布的精细化和动态控制；所述角膜交联照明图像包括中心的圆形和在所述圆形的外周上均匀间隔分布的六条矩形柱，形成从中心向外发散的星形形状。A digital optical device for patterning corneal cross-linking, for providing a corneal cross-linking illumination image, the device includes an ultraviolet light source system and a collimation system, and the ultraviolet light source system is used for providing adjustable power stability Ultraviolet light, the collimation system is used to collimate ultraviolet light beams, the device further includes a beam modulation system, a projection lighting system, and a control system, the beam modulation system includes a digital light projection chip with a micro-mirror array, the The digital light projection chip subdivides the collimated ultraviolet light beam into a plurality of controllable small beams, and the control system controls the deflection of each micro-mirror of the digital light projection chip in a predetermined manner to achieve the corresponding The use of small beams and the control of the ratio of deflection time to undeflected time per unit time of each micro-mirror, that is, the duty cycle, to control the lighting energy of each small beam per unit time to generate corresponding Of a predetermined area having a different predetermined intensity distribution, the modulated light beam is projected onto the illumination by the projection lighting system Domain to achieve fine and dynamic control of the range and energy distribution of the corneal cross-linking area; the corneal cross-linking illumination image includes a circle in the center and six rectangular columns evenly spaced on the outer periphery of the circle to form Star shape diverging outward from the center.
本发明具有如下有益效果：The invention has the following beneficial effects:
本发明提供的光学装置具有对角膜交联区域范围和能量分布进行控制的能力，可以实现对角膜交联区域范围和能量分布的精细化和动态控制，能实现特定照明图像的产生，灵活地满足圆锥角膜患者个性化治疗需求，可用于治疗近视、远视、散光等有关眼球光学系统屈光能力的眼科疾病，可在减少角膜照射区域和角膜伤害的同时达到更好的治疗效果，极大地提高了角膜交联手术的治疗效果和效率，并为精准的角膜交联力学建模提供了研究可能和优越的实验设备。The optical device provided by the present invention has the ability to control the range and energy distribution of the corneal cross-linked area, can realize the refinement and dynamic control of the range and energy distribution of the corneal cross-linked area, can realize the generation of specific lighting images, and flexibly meet Patients with keratoconus can be used for the treatment of myopia, hyperopia, astigmatism and other eye diseases related to the refractive power of the eyeball optical system. It can reduce the corneal irradiation area and corneal damage while achieving better treatment results, greatly improving The treatment effect and efficiency of corneal cross-linking surgery provide research possibilities and superior experimental equipment for accurate corneal cross-linking mechanical modeling.
本发明还提供了产生一种特定的照明治疗图案的光学装置，不同于现有设备产生圆形光斑，本发明的光学装置产生特定的星形形状照明治疗图案，既缩小了交联区域减小了对角膜的损伤，又能实现很好治疗效果，达到设定的角膜强度。The present invention also provides an optical device for generating a specific illumination treatment pattern. Unlike the existing device which generates a circular light spot, the optical device of the present invention generates a specific star-shaped illumination treatment pattern, which reduces the cross-linking area and reduces In order to damage the cornea, it can achieve a good therapeutic effect and reach the set corneal strength.
本发明用于图案化角膜交联的数字化光学装置还可以用于进行相关图案化角膜交联的实验，探究角膜交联对角膜组织整体力学性能的影响，实现角膜交联反应的建模，以最终针对具体角膜疾病提供很好的视力恢复方案。The digital optical device for patterned corneal cross-linking of the present invention can also be used for experiments related to patterned corneal cross-linking, to explore the effect of corneal cross-linking on the overall mechanical properties of corneal tissue, and to realize the modeling of corneal cross-linking reactions. Eventually provide a good vision recovery program for specific corneal diseases.
图1为本发明一种实施例的图案化角膜交联的数字化光学装置的结构框图；1 is a structural block diagram of a patterned corneal cross-linked digital optical device according to an embodiment of the present invention;
图2为本发明一种实施例的图案化角膜交联的数字化光学装置的光路示意图；2 is a schematic diagram of an optical path of a patterned corneal cross-linked digital optical device according to an embodiment of the present invention;
图3为本发明一种实施例的图案化角膜交联的数字化光学装置产生的角膜交联照明图案；FIG. 3 is a corneal cross-linked illumination pattern generated by a patterned corneal cross-linked digital optical device according to an embodiment of the present invention; FIG.
图4为本发明一种实施例的图案化角膜交联的数字化光学装置产生的其他几种角膜交联照明图案。FIG. 4 shows several other corneal cross-linked illumination patterns generated by a patterned corneal cross-linked digital optical device according to an embodiment of the present invention.
以下对本发明的实施方式作详细说明。应该强调的是，下述说明仅仅是示例性的，而不是为了限制本发明的范围及其应用。Hereinafter, embodiments of the present invention will be described in detail. It should be emphasized that the following description is merely exemplary and is not intended to limit the scope of the present invention and its application.
参阅图1至图2，在一种实施例中，一种用于图案化角膜交联的数字化光学装置，包括紫外光源系统和准直系统1、光束调制系统3、投影照明 系统4和控制系统，所述紫外光源系统用于提供功率可调的稳定紫外光，所述准直系统用于准直紫外光束，所述光束调制系统3包括具有微反射镜阵列的数字化光投影芯片，所述数字化光投影芯片将经准直的紫外光束细分为多个可控小光束，所述控制系统按照预定的方式控制所述数字化光投影芯片各个微反射镜的偏转与否来达到对各个相应的小光束的使用与否，并控制各个微反射镜的每单位时间内偏转时间与未偏转时间的比值，即空占比，以控制各个小光束每单位时间内的照明能量，来产生对应于不同的预定区域具有不同的预定强度分布的照射，通过所述投影照明系统4将已调制光束投射到照明区域，以实现对角膜交联区域范围和能量分布的精细化和动态控制。1 to 2, in one embodiment, a digital optical device for patterned corneal cross-linking includes an ultraviolet light source system and a collimation system 1, a beam modulation system 3, a projection lighting system 4, and a control system. The ultraviolet light source system is used to provide stable ultraviolet light with adjustable power, the collimation system is used to collimate ultraviolet light beams, and the beam modulation system 3 includes a digitized light projection chip having a micro-mirror array, the digitization The light projection chip subdivides the collimated ultraviolet beam into a plurality of controllable small beams, and the control system controls the deflection of each micro-mirror of the digital light projection chip in a predetermined manner to achieve the corresponding small beams. The use of light beams, and the ratio of deflection time to undeflected time per unit time of each micro-mirror, that is, the duty cycle, to control the illumination energy of each small beam per unit time to generate different Irradiation of predetermined areas with different predetermined intensity distributions, the modulated light beam is projected onto the illuminated area by the projection lighting system 4 to achieve the cornea Fine and dynamic control of the domains and the range of energy distribution.
该光学装置可以实现对角膜交联区域范围和能量分布的精细化和动态控制，极大地提高了角膜交联手术的治疗效果和效率，并为精准的角膜交联力学建模提供了研究可能和优越的实验设备。由于该光学装置具有对角膜交联区域范围和能量分布进行精细、动态控制的能力，可以在减少角膜照射区域和角膜伤害的同时达到很好的治疗效果。The optical device can realize the fine and dynamic control of the range and energy distribution of the corneal cross-linking, which greatly improves the treatment effect and efficiency of corneal cross-linking surgery, and provides research possibilities and precise research on the mechanical modeling of corneal cross-linking. Superior experimental equipment. Because the optical device has the ability to finely and dynamically control the range and energy distribution of the corneal cross-linking area, it can achieve a good therapeutic effect while reducing the corneal irradiation area and the corneal injury.
在优选的实施例中，光学装置还包括设置于所述准直系统和所述光束调制系统3之间的匀光系统2，所述匀光系统2包括微透镜组和反射镜组，通过所述微透镜组与反射镜组对经准直的紫外光束进行均匀化处理再传送至所述光束调制系统3进行调制。In a preferred embodiment, the optical device further includes a uniform light system 2 disposed between the collimation system and the beam modulation system 3. The uniform light system 2 includes a micro lens group and a mirror group. The micro-lens group and the mirror group perform homogenization processing on the collimated ultraviolet light beam, and then transmit the homogenized ultraviolet light beam to the light beam modulation system 3 for modulation.
在优选的实施例中，所述准直系统包括球面反射镜和准直透镜组，通过所述球面反射镜汇聚紫外光束，再利用所述准直透镜组对紫外光束进行准直。In a preferred embodiment, the collimation system includes a spherical mirror and a collimating lens group, and an ultraviolet beam is focused by the spherical mirror, and then the collimating lens group is used to collimate the ultraviolet beam.
在优选的实施例中，所述紫外光源系统包括紫外光源和电源模块，所述紫外光源的发光功率不大于5瓦，发射的紫外线波长为360至370nm，所述电源模块提供0至5A连续可调的电流。In a preferred embodiment, the ultraviolet light source system includes an ultraviolet light source and a power module. The ultraviolet light source has a luminous power of not more than 5 watts, and the emitted ultraviolet wavelength is 360 to 370 nm. The power module provides 0 to 5A continuous power. Regulated current.
在优选的实施例中，所述紫外光源系统还包括设置在光源周围的曲面反射镜，用于对紫外光进行反射汇聚。In a preferred embodiment, the ultraviolet light source system further includes a curved reflector disposed around the light source, for reflecting and condensing the ultraviolet light.
在优选的实施例中，所述投影照明系统4经设置能够由所述控制系统控制其投影距离。In a preferred embodiment, the projection lighting system 4 is configured to be capable of controlling its projection distance by the control system.
在优选的实施例中，所述投影照明系统4包括透镜组，该透镜组中各透镜的相对位置经设置可微调以实现对照射区域范围的控制。In a preferred embodiment, the projection lighting system 4 includes a lens group, and the relative position of each lens in the lens group is set to be fine-tunable to control the range of the irradiation area.
在优选的实施例中，所述投影照明系统4的透镜组经设置使得所述控制系统能够对透镜间的相对位置进行调整来微调在固定的投影距离上形成 的投影图像的大小。In a preferred embodiment, the lens group of the projection lighting system 4 is set so that the control system can adjust the relative position between the lenses to fine-tune the size of the projection image formed at a fixed projection distance.
在优选的实施例中，所述光束调制系统3经设置以使对于照明图像达到50微米的控制精度。In a preferred embodiment, the beam modulation system 3 is configured to achieve a control accuracy of 50 micrometers for the illumination image.
参阅图1至图2，在另一特定的实施例中，一种用于图案化角膜交联的数字化光学装置，用于提供一种角膜交联照明图像，所述装置包括紫外光源系统和准直系统1、光束调制系统3、投影照明系统4和控制系统，所述紫外光源系统用于提供功率可调的稳定紫外光，所述准直系统用于准直紫外光束，所述光束调制系统3包括具有微反射镜阵列的数字化光投影芯片，所述数字化光投影芯片将经准直的紫外光束细分为多个可控小光束，所述控制系统按照预定的方式控制所述数字化光投影芯片各个微反射镜的偏转与否来达到对各个相应的小光束的使用与否，并控制各个微反射镜的每单位时间内偏转时间与未偏转时间的比值，即空占比，以控制各个小光束每单位时间内的照明能量，来产生对应于不同的预定区域具有不同的预定强度分布的照射，通过所述投影照明系统4将已调制光束投射到照明区域，以实现对角膜交联区域范围和能量分布的精细化和动态控制；所述角膜交联照明图像包括中心的圆形和在所述圆形的外周上均匀间隔分布的六条矩形柱，形成从中心向外发散的星形形状。Referring to FIG. 1 to FIG. 2, in another specific embodiment, a digital optical device for patterning corneal cross-linking is used to provide a corneal cross-linking illumination image. The device includes an ultraviolet light source system and a light source. A collimation system 1, a beam modulation system 3, a projection lighting system 4, and a control system, the ultraviolet light source system is used to provide stable ultraviolet light with adjustable power, the collimation system is used to collimate ultraviolet light beams, and the beam modulation system 3 includes a digitized light projection chip with a micro-mirror array, the digitized light projection chip subdivides the collimated ultraviolet beam into a plurality of controllable small beams, and the control system controls the digitized light projection in a predetermined manner The deflection of each micro-mirror of the chip is used to achieve the use of each corresponding small beam, and the ratio of deflection time to undeflected time per unit time of each micro-mirror is controlled, that is, the duty cycle, to control each The illumination energy of a small light beam per unit time is used to generate illumination with different predetermined intensity distributions corresponding to different predetermined regions. 4 The modulated light beam is projected to the illumination area to achieve fine and dynamic control of the range and energy distribution of the corneal cross-linking area; the corneal cross-linking illumination image includes a circle in the center and is uniform on the outer periphery of the circle Six rectangular columns spaced apart form a star shape that diverges outward from the center.
不同于现有设备产生圆形光斑，本发明实施例的光学装置产生星形形状的特定照明治疗图案，其既缩小了交联区域，减小了对角膜的损伤，又能实现很好治疗效果，达到设定的角膜强度。Unlike the existing equipment that produces circular light spots, the optical device of the embodiment of the present invention generates a specific lighting treatment pattern in the shape of a star, which not only reduces the cross-linking area, reduces damage to the cornea, but also achieves a good therapeutic effect. To reach the set corneal strength.
在优选的实施例中，光学装置还包括设置于所述准直系统和所述光束调制系统3之间的匀光系统2，所述匀光系统2包括微透镜组和反射镜组，通过所述微透镜组与反射镜组对经准直的紫外光束进行均匀化处理再传送至所述光束调制系统3进行调制。In a preferred embodiment, the optical device further includes a uniform light system 2 disposed between the collimation system and the beam modulation system 3. The uniform light system 2 includes a micro lens group and a mirror group. The micro-lens group and the mirror group perform homogenization processing on the collimated ultraviolet light beam, and then transmit the homogenized ultraviolet light beam to the light beam modulation system 3 for modulation.
一个具体实施例的图案化角膜交联的数字化光学装置的光路示意图如图2所示，图案化角膜交联的数字化光学装置包括：沿光路设置的紫外光源系统和准直系统1、匀光系统2、光束调制系统3、投影照明系统4以及控制系统(未图示)。在紫外光源系统和准直系统1中，由发光二极管发出波长为360至370的近紫外光，再由光源周围的曲面反射镜进行反射汇聚，然后经由准直透镜组2对光线进行准直，之后光线照射到光束调制模块3中的数字投影芯片上，最后调制过的光束通过投影系统4照射到角膜的指定区域。控制光束调制系统调制时，一方面，控制系统改变微反射镜阵列中的各个反射镜的方向，将不需要保留的微小光束偏转(可使用额外 的能量吸收装置吸收偏转光束)，而需要保留的光束仍按照原有路径传播；另一方面，控制光束调制系统3中各个反射镜的每单位时间内偏转时间与未偏转时间的比值，即空占比，通过控制这一参数，可以达到控制各个微小光束每单位时间内的照明能量，即照明功率。此外，在投影系统中，可以对透镜间的相对位置进行调整来微调固定投影距离上投影图像的大小。A schematic diagram of the optical path of the patterned corneal cross-linked digital optical device in a specific embodiment is shown in FIG. 2. The patterned corneal cross-linked digital optical device includes an ultraviolet light source system and a collimation system 1 and a uniform light system arranged along the optical path. 2. Beam modulation system 3, projection lighting system 4, and control system (not shown). In the ultraviolet light source system and the collimation system 1, near-ultraviolet light having a wavelength of 360 to 370 is emitted by a light emitting diode, and then is reflected and converged by a curved mirror around the light source, and then the light is collimated through a collimating lens group 2. The light is then irradiated onto the digital projection chip in the beam modulation module 3, and the finally modulated beam is irradiated to a designated area of the cornea through the projection system 4. When controlling the modulation of the beam modulation system, on the one hand, the control system changes the direction of each mirror in the micro-mirror array, and it will deflect the tiny beams that do not need to be retained (the deflected beams can be absorbed using additional energy absorption devices), The light beam still propagates according to the original path; on the other hand, the ratio of the deflection time to the undeflected time per unit time of each mirror in the beam modulation system 3 is controlled, that is, the duty cycle. By controlling this parameter, it is possible to control each The lighting energy of a tiny light beam per unit time, that is, the lighting power. In addition, in a projection system, the relative position between the lenses can be adjusted to fine-tune the size of the projected image at a fixed projection distance.
图3和图4为本发明实施例的图案化角膜交联的数字化光学装置产生的几种角膜交联照明图案示例。FIG. 3 and FIG. 4 are examples of several corneal cross-linked illumination patterns generated by a digitalized optical device for patterned corneal cross-linking according to an embodiment of the present invention.
以上内容是结合具体/优选的实施方式对本发明所作的进一步详细说明，不能认定本发明的具体实施只局限于这些说明。对于本发明所属技术领域的普通技术人员来说，在不脱离本发明构思的前提下，其还可以对这些已描述的实施方式做出若干替代或变型，而这些替代或变型方式都应当视为属于本发明的保护范围。The above content is a further detailed description of the present invention in combination with specific / preferred embodiments, and it cannot be considered that the specific implementation of the present invention is limited to these descriptions. For those of ordinary skill in the technical field to which the present invention pertains, without departing from the concept of the present invention, they can also make several alternatives or modifications to the described embodiments, and these alternatives or modifications should be regarded as It belongs to the protection scope of the present invention.
Claims (10)
- 一种用于图案化角膜交联的数字化光学装置，包括紫外光源系统和准直系统，所述紫外光源系统用于提供功率可调的稳定紫外光，所述准直系统用于准直紫外光束，其特征在于，还包括光束调制系统、投影照明系统和控制系统，所述光束调制系统包括具有微反射镜阵列的数字化光投影芯片，所述数字化光投影芯片将经准直的紫外光束细分为多个可控小光束，所述控制系统按照预定的方式控制所述数字化光投影芯片各个微反射镜的偏转与否来达到对各个相应的小光束的使用与否，并控制各个微反射镜的每单位时间内偏转时间与未偏转时间的比值，即空占比，以控制各个小光束每单位时间内的照明能量，来产生对应于不同的预定区域具有不同的预定强度分布的照射，通过所述投影照明系统将已调制光束投射到照明区域，以实现对角膜交联区域范围和能量分布的精细化和动态控制。A digital optical device for patterned corneal cross-linking includes an ultraviolet light source system and a collimation system, the ultraviolet light source system is used to provide stable ultraviolet light with adjustable power, and the collimation system is used to collimate an ultraviolet beam It is characterized in that it further includes a beam modulation system, a projection lighting system and a control system. The beam modulation system includes a digital light projection chip with a micro-mirror array, and the digital light projection chip subdivides the collimated ultraviolet light beam. For a plurality of controllable small beams, the control system controls the deflection of each micro-mirror of the digital light projection chip in a predetermined manner to achieve the use of each corresponding small beam, and controls each micro-mirror The ratio of the deflection time to the undeflected time per unit time, that is, the duty cycle, to control the illumination energy of each small beam per unit time to generate irradiation with different predetermined intensity distributions corresponding to different predetermined areas. The projection lighting system projects the modulated light beam to the illumination area to realize the range and energy of the corneal cross-linking area. Dynamic control and fine distribution.
- 如权利要求1所述的数字化光学装置，其特征在于，还包括设置于所述准直系统和所述光束调制系统之间的匀光系统，所述匀光系统包括微透镜组和反射镜组，通过所述微透镜组与反射镜组对经准直的紫外光束进行均匀化处理再传送至所述光束调制系统进行调制。The digital optical device according to claim 1, further comprising a uniform light system disposed between the collimation system and the beam modulation system, the uniform light system comprising a micro lens group and a mirror group , Homogenizing the collimated ultraviolet light beam through the micro lens group and the mirror group, and then transmitting it to the beam modulation system for modulation.
- 如权利要求1或2所述的数字化光学装置，其特征在于，所述准直系统包括球面反射镜和准直透镜组，通过所述球面反射镜汇聚紫外光束，再利用所述准直透镜组对紫外光束进行准直。The digital optical device according to claim 1 or 2, wherein the collimation system comprises a spherical mirror and a collimating lens group, and an ultraviolet beam is focused by the spherical mirror, and then the collimating lens group is used. Collimates the UV beam.
- 如权利要求1至3任一项所述的数字化光学装置，其特征在于，所述紫外光源系统包括紫外光源和电源模块，所述紫外光源的发光功率不大于5瓦，发射的紫外线波长为360至370nm，所述电源模块提供0至5A连续可调的电流。The digital optical device according to any one of claims 1 to 3, wherein the ultraviolet light source system comprises an ultraviolet light source and a power source module, the light emitting power of the ultraviolet light source is not greater than 5 watts, and the emitted ultraviolet wavelength is 360 To 370nm, the power module provides a continuously adjustable current from 0 to 5A.
- 如权利要求1至4任一项所述的数字化光学装置，其特征在于，所述紫外光源系统还包括设置在光源周围的曲面反射镜，用于对紫外光进行反射汇聚。The digital optical device according to any one of claims 1 to 4, wherein the ultraviolet light source system further comprises a curved reflector arranged around the light source for reflecting and condensing ultraviolet light.
- 如权利要求1至5任一项所述的数字化光学装置，其特征在于，所述投影照明系统经设置能够由所述控制系统控制其投影距离。The digital optical device according to any one of claims 1 to 5, wherein the projection lighting system is configured to be capable of controlling a projection distance thereof by the control system.
- 如权利要求1至6任一项所述的数字化光学装置，其特征在于，所述投影照明系统包括透镜组，该透镜组中各透镜的相对位置经设置可微调以实现对照射区域范围的控制。The digital optical device according to any one of claims 1 to 6, wherein the projection illumination system includes a lens group, and the relative positions of the lenses in the lens group are set to be fine-tunable to control the range of the irradiation area. .
- 如权利要求7所述的数字化光学装置，其特征在于，所述投影照 明系统的透镜组经设置使得所述控制系统能够对透镜间的相对位置进行调整来微调在固定的投影距离上形成的投影图像的大小。The digital optical device according to claim 7, wherein the lens group of the projection illumination system is set so that the control system can adjust the relative position between the lenses to fine-tune the projection formed at a fixed projection distance. The size of the image.
- 如权利要求1至8任一项所述的数字化光学装置，其特征在于，所述光束调制系统经设置以使对于照明图像达到50微米的控制精度。The digital optical device according to any one of claims 1 to 8, wherein the light beam modulation system is configured to achieve a control accuracy of 50 micrometers for the illumination image.
- 一种用于图案化角膜交联的数字化光学装置，用于提供一种角膜交联照明图像，所述装置包括紫外光源系统和准直系统，所述紫外光源系统用于提供功率可调的稳定紫外光，所述准直系统用于准直紫外光束，其特征在于，还包括光束调制系统、投影照明系统和控制系统，所述光束调制系统包括具有微反射镜阵列的数字化光投影芯片，所述数字化光投影芯片将经准直的紫外光束细分为多个可控小光束，所述控制系统按照预定的方式控制所述数字化光投影芯片各个微反射镜的偏转与否来达到对各个相应的小光束的使用与否，并控制各个微反射镜的每单位时间内偏转时间与未偏转时间的比值，即空占比，以控制各个小光束每单位时间内的照明能量，来产生对应于不同的预定区域具有不同的预定强度分布的照射，通过所述投影照明系统将已调制光束投射到照明区域，以实现对角膜交联区域范围和能量分布的精细化和动态控制；所述角膜交联照明图像包括中心的圆形和在所述圆形的外周上均匀间隔分布的六条矩形柱，形成从中心向外发散的星形形状。A digital optical device for patterning corneal cross-linking, for providing a corneal cross-linking illumination image, the device includes an ultraviolet light source system and a collimation system, and the ultraviolet light source system is used for providing adjustable power stability For ultraviolet light, the collimation system is used for collimating ultraviolet light beams, and further includes a beam modulation system, a projection lighting system, and a control system. The beam modulation system includes a digital light projection chip having a micro-mirror array. The digital light projection chip divides the collimated ultraviolet light beam into a plurality of controllable small beams, and the control system controls the deflection of each micro-mirror of the digital light projection chip in a predetermined manner to achieve the corresponding response. The use of small beams is controlled, and the ratio of deflection time to undeflected time per unit time of each micro-mirror is controlled, that is, the duty ratio, to control the lighting energy of each small beam per unit time to generate the corresponding Illumination of different predetermined areas with different predetermined intensity distributions, the modulated light beam is projected to by the projection lighting system Bright area to achieve fine and dynamic control of the range and energy distribution of the corneal cross-linking area; the corneal cross-linking illumination image includes a circle in the center and six rectangular columns evenly spaced on the outer periphery of the circle, Form a star shape that diverges outward from the center.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105498097A (en) * | 2015-12-23 | 2016-04-20 | 济南三维医疗器械有限公司 | Corneal cross-linking instrument |
| US20160338588A1 (en) * | 2015-05-22 | 2016-11-24 | Avedro, Inc. | Systems and methods for monitoring cross-linking activity for corneal treatments |
| CN106236372A (en) * | 2016-08-17 | 2016-12-21 | 浙江大学 | A kind of method and apparatus of digitized corneal cross-linking regulation corneal curvature radius |
| CN106264855A (en) * | 2016-10-13 | 2017-01-04 | 清华大学深圳研究生院 | A kind of device for treating cornea tissue disease |
| CN107189089A (en) * | 2017-05-10 | 2017-09-22 | 上海旷视医疗科技有限公司 | The system for realizing photochemical crosslinking using UV LED tunable light sources |
| CN107205845A (en) * | 2014-10-27 | 2017-09-26 | 艾维德洛公司 | System and method for the crosslinking treatment of eye |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120215155A1 (en) * | 2010-03-19 | 2012-08-23 | Avedro Inc. | Controlled cross-linking initiation and corneal topography feedback systems for directing cross-linking |
| CN102727176B (en) * | 2011-04-11 | 2015-04-01 | 上海美沃精密仪器有限公司 | System and method of handhold slit lamp |
| KR102002634B1 (en) * | 2013-01-28 | 2019-07-22 | 노바르티스 아게 | Apparatus for corneal crosslinking |
| EP3062750B1 (en) * | 2013-10-30 | 2021-04-21 | Alcon Inc. | Crosslinking control |
| CN104225794B (en) * | 2014-06-29 | 2017-06-27 | 李思思 | The method for designing of infrared heat effect and non-thermal effect therapeutic equipment |
| JP6516219B2 (en) * | 2015-06-24 | 2019-05-22 | 公立大学法人名古屋市立大学 | Photodynamic therapy light irradiator |
| WO2018063137A1 (en) * | 2016-09-27 | 2018-04-05 | Yichieh Shiuey | Systems, device, and method for cross-linking corneal tissue |
-
2018
- 2018-05-29 CN CN201810533913.8A patent/CN108744293B/en active Active
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107205845A (en) * | 2014-10-27 | 2017-09-26 | 艾维德洛公司 | System and method for the crosslinking treatment of eye |
| US20160338588A1 (en) * | 2015-05-22 | 2016-11-24 | Avedro, Inc. | Systems and methods for monitoring cross-linking activity for corneal treatments |
| CN105498097A (en) * | 2015-12-23 | 2016-04-20 | 济南三维医疗器械有限公司 | Corneal cross-linking instrument |
| CN106236372A (en) * | 2016-08-17 | 2016-12-21 | 浙江大学 | A kind of method and apparatus of digitized corneal cross-linking regulation corneal curvature radius |
| CN106264855A (en) * | 2016-10-13 | 2017-01-04 | 清华大学深圳研究生院 | A kind of device for treating cornea tissue disease |
| CN107189089A (en) * | 2017-05-10 | 2017-09-22 | 上海旷视医疗科技有限公司 | The system for realizing photochemical crosslinking using UV LED tunable light sources |
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