WO2019212374A1

WO2019212374A1 - Multifunctional bodies for controlled illumination and disinfection of premises at high risk of infection and their uses

Info

Publication number: WO2019212374A1
Application number: PCT/RO2019/000004
Authority: WO
Inventors: Răzvan-Cătălin BUCUREŞTEANU
Original assignee: Bucuresteanu Razvan Catalin
Priority date: 2017-12-22
Filing date: 2019-02-22
Publication date: 2019-11-07

Abstract

Present invention discloses multifunctional bodies used for controlled illumination and disinfection of premises at high risk of infection. The multifunctional bodies for controlled illumination and disinfection comprises a LED-based tertiary emission source which uses several types of LEDs configured to emit, at the same time, at 740nm - 780nm with a spectral peak of 760nm, 660nm - 700nm with a spectral peak of 687nm, 620nm - 640nm with a spectral peak of 630nm, 570nm - 590nm with a spectral peak of 577nm, 510nm -540nm with a spectral peak of 530nm, 470nm - 490nm with a spectral peak of 477nm and is not configured to emit at wavelengths between 400nm - 420nm. The multifunctional body may include additionally a main source comprising emission sources based on LED emitting electromagnetic radiations ensuring a degree of illumination of surfaces of at least 240 lux at 80 cm from the ground and may also include a secondary source comprising LED-based emission sources configured to emit, continuously or in a pulsating manner, a 460-500 nm electromagnetic radiation with a spectral peak of 470 nm.

Description

MULTIFUNCTIONAL BODIES FOR CONTROLLED ILLUMINATION AND DISINFECTION OF PREMISES AT HIGH RISK OF INFECTION AND THEIR USES

The present invention relates to multifunctional bodies used for controlled illumination and disinfection of premises at high risk of infection. The multifunctional bodies described in the present invention are used for the controlled illumination and disinfection of health facilities, medical facilities such as a ward, either AIT or pre- or post - operatory blocks, medical consulting rooms, hospital lounges, patient waiting rooms, generally in any premises such as medical and treatment facilities, schools, kindergartens, canteens, warehouses and grocery stores where nosocomial infections are at risk of spreading and dissemination.

State of the art

Methods utilizing UV-based fluorescent lamps for the disinfection and control of nosocomial infections in hospitals and premiss at increased risk of infection are known. The disadvantage of these methods is the use of UV radiation that is dangerous to humans. Disinfection with UV radiation of premises at increased risk of infection can only be done in the absence of humans, and continuous disinfection can not be achieved. Also, these equipments are rather expensive, and fluorescent lamps have a limited service life in time.

Patent EP 2554583 B1 discloses a LED light source for disinfection in closed environments using ultraviolet electromagnetic radiation. Such wavelengths in the ultraviolet spectral range are not suitable for general illumination, due to UV negative effects on humans.

Patent CN 104056289 A describes a light source combining LEDs with a UV radiation lamp. Such a method is inappropriate for general illumination due to harmful effects on humans.

Patent U.S. 6.251.127 describes a photodynamic procedure for inactivating bacteria and fungal wound infections using methylene blue or toluidine blue, a photosensitizer that is activated by light radiation in the range of 500 nm to 580 nm. The biocidal action of this process is accomplished by transforming the photosensitizer, by light, into a chemical agent acting on the bacteria. Patents US 9039966 and US8398264 B2 describe a method of inactivating Gram positive bacteria using a light radiation with a wavelength of 405 nm, namely in the 400 nm - 420 nm spectrum.

Patent US 20170014538 describes a LED structure and a illuminating body for continuous disinfection of premises based on white light, but uses as a biocidal radiation light with a wavelength of 405 nm, wavelength that affects humans, especially the skin and the human eye.

Due to the harmful effects of UV radiation on humans, disinfection can not be carried out continuously, so that when the personnel enter the premises, the devices must be shut down and thus the antimicrobial protection created ceases. As a result, there is a risk of microbiological infection if the required disinfection time has not been taken into account, or microbial germs can occur due to aerosol or staff carrying them.

Another disadvantage of the methods used in the prior art is that UV radiation is less effective for disinfection of areas shielded or protected by solid objects. UV-C light damages plastics and polymers used in the medical environment, if exposed repeatedly. There is a series of studies that have shown that UV-C radiation penetrates in a very low extent the matrix of mucopolysaccharides of bacterial biofilms. Because of this, it appears that, under certain conditions, UV-C radiation is less effective to remove biofilms.

In the paper Study of the Response of a Biofilm Bacterial Community to UV Radiation, American Society for Microbiology, Vol. 65, No. 5 (1999), researchers O.E. Mohamd and R.V. Miller showed that Type C UV radiation has a low absorption in biofilm. Because of this, disinfection with UV radiation is not recommended for first-line disinfection and combating nosocomial infections.

Another disadvantage is the use of expensive and hard-to-handle materials and devices that can not be used to provide illumination of the room, while disinfecting it.

Light-activated antimicrobial agents irradiated with wavelengths of 665, respectively 633 nm (laser range) which exhibit an antibacterial activity and inhibit the development of Staphylococcus aureus and Porphyromonas gingivalis are known in the art.

Photocatalytic compositions used for the antimicrobial protection of surfaces which are made of semiconductive metal oxides, as light-activated antimicrobial agents (LAAAs), photochemicaly activated by a corresponding electromagnetic radiation flux emitted in the visible spectrum of 450 nm - 500 nm (R0132438) are also known. This patent application discloses a composition of biocidal washable paint with photocatalytic properties and a photocatalytic method of activating this composition. The composition described in this patent application is made based on photosensitizers from semiconductive metal oxides of Ti02 or ZnO, doped with transition metal ions.

It is known that an important method for combating nosocomial infections is by reducing microbial load in medical premises or in areas where there is a risk of pathogenic germs being transmitted by air. To combat the microbial load, are used far ultraviolet emission lamps or in the spectral range of 380 nm - 420 nm. The need to reduce the microbial load on the indoor surfaces of medical facilities has led to the emergency of new types of photocatalytic compositions being used for the antimicrobial protection of said surfaces. These compositions are made on the basis of semiconductive metal oxides such as Ti02 or ZnO, photocatalytic oxides which, by light excitation, function as light- activated antimicrobial agents (LAAAs), destroying nosocomial pathogens.

A method of inactivating Gram positive bacteria, namely Staphylococcus aureus, including methicilin-resistant Staphylococcus aureus (MRSA) variant, coagulase- negative Staphylococcus bacteria, Streptococcus, Enterococcus and Clostridium species is described in Patent US 9039966 and Patent 8398264 B2, by using a light radiation with a wavelength of 405 nm, respectively in the 400 nm - 420 nm spectrum. The first disadvantage of this method is given by the wavelength very close to the UV limit and having negative effects on the skin or the retina of the human eye. The second disadvantage of this method is given by the fact that their action is mainly manifested on Gram-positive microorganisms. As a photochemical method, electromagnetic radiations of 405 nm wavelength of the above-mentioned patents easily penetrates the wall of the microorganisms, acts and excites the porphyrin molecules present in bacteria, porphyrins that function as a photosensitizer and produce intracellular reactive oxygen species, followed by the destruction of cells by reactive oxygen species intracellularly produced through this method. The described 405 nm electromagnetic radiations do not produce reactive oxygen species, only act on porphyrin molecules and intrabacterial RNA and, therefore, they can not act on spores of microorganisms or biofilms formed by microorganisms.

Technical problem to be solved is to provide multifunctional bodies that can disinfect a premise with increased high risk of infection, while illuminating it, without negative effects on the human on the premises, operating continuously at low costs, and being at least as effective as the methods known in the art.

This problem is solved in a first aspect by providing the multifunctional body according to claim 1.

More preferably, the invention provides a multifunctional body in which the LEDs are configured to emit, at the same time, at the following wavelengths:

- 750 nm - 780 nm with a spectral peak of 760 nm,

- 680 nm - 700 nm with a spectral peak of 687 nm

- 620 nm - 640 nm with a spectral peak of 630 nm,

- 570 nm - 590 nm with a spectral peak of 577 nm,

- 520 nm - 540 nm with a spectral peak of 530 nm,

- 470 nm - 490 nm with a spectral peak of 477 nm,

where the power density of the radiation emitted is at least 60 J / cm² measured at a distance of 1.5 m from the emission source.

Mechanism

The inventors of the present invention consider the following mechanism to provide the above-described technical effects, based on obtaining a combined flux of electromagnetic radiation emitted by the multifunctional body that delivers simultaneously light necessary to optical comfort, and inhibition of microorganism development by activating membrane photoreceptors and generating singlet oxygen species and photochemical activation of photocatalytic coating compositions.

Thus, the multifunctional body according to the present invention comprises an emission source, hereinafter referred to as tertiary source, which emits concurrently energy quantums in the form of electromagnetic radiation with different wavelengths of 740 nm - 780 nm with a spectral peak of 760 nm, 660 nm - 700 nm with a spectral peak of 687 nm, 620 nm - 640 nm with a spectral peak of 630 nm, 570 nm - 590 nm with a spectral peak of 577 nm, 510 nm - 540 nm with a spectral peak of 530 nm, 470 nm - 490 nm with a spectral peak of 477nm, and the energy of these electromagnetic radiation is at least 60 J / cm² measured at a distance of 1.5 m from the emission source. If the energy of electromagnetic radiation is less than 60 J / cm² measured at a distance of 1.5 m from the emission source, the energy required to produce the photochemical phenomena described below is not provided.

A first photochemical phenomenon consists in obtaining the singlet oxygen reactive species as follows. Energy quantums of electromagnetic radiation with different wavelengths described in the present invention, by their propagation in the space of the premises, act on the molecular oxygen in the air through physical absorption and photoexcitation processes, and by the photochemical process induced by these energetic quanta takes place the conversion of molecular oxygen into the singlet oxygen reactive species having a high chemical reactivity, given the basic triplet state of the oxygen molecule.

Singlet oxygen molecular species have a high affinity, especially for the unsaturated bonds of proteins in the biochemical structure of bacterial walls. They act on pathogens in the air and on the exposed areas, acting on bacterial walls by destroying chemical bonds in the structure thereof - whether they are Gram-positive, Gram-negative or fungi, with or without resistance to antibiotics, or destroy chemical bonds in the structure of the web of biofilms and thus, acting directly on the bacteria.

A second photochemical phenomenon consists in the activation of the microbiological photoreceptors located on the membrane of nosocomial pathogens by simultaneously emission of radiation by the tertiary source, at wavelengths of: 740 nm - 780 nm (spectral peak at 760 nm), 660 - 700 nm (spectral peak at 687 nm), 620 nm - 640 nm (spectral peak at 630 nm), 570 nm - 590 nm (spectral peak at 577 nm), 510 nm - 540 nm (spectral peak at 530 nm), 470 nm - 490 nm (spectral peak at 477 nm), providing an electromagnetic radiation energy of at least 60 J / cm² measured at a distance of 1.5 m from the emission source.

Membrane photoreceptors are macromolecular peptide chains containing flavines and porphyrins forming, on the surface of the cell wall, specialized protein enzymes, sensitive to radiation of a certain wavelength, playing the part of signaling and modifying the metabolic pathways depending on environmental conditions. They are encoded by the bacterial genome and trigger, upon their activation, a series of metabolic pathways that control the development of nosocomial pathogens. Depending on the spectral domain which these protein enzymes are sensitive to, the photoreceptors are divided into several classes of membrane photoreceptors: BLUF (blue light sensing using flavin), PYP (photoactive yellow protein), Cyclic di-GMP (cyclic diguanylate), LOV (light, oxygen, voltage), FAD (flavin adenine dinucleotide), FMN (flavin mononucleotide). The spectral domains described above are characteristic of the Q and Sorret absorption bands of porphyrins and flavins. It has been found that, by using the tertiary source of LED modules that emit radiations in the above mentioned wavelength, the membrane photoreceptors of microorganisms are activated, triggering a series of metabolic processes to inhibit the development of nosocomial pathogens.

Brief Description of the Invention

In a second aspect, the invention provides an illumination body comprising a first emission source, a tertiary source, and a second emission source, hereinafter referred to as the secondary source. The secondary source comprises LED-based emission sources configured to emit, continuously or in a pulsating manner, a 460-500 nm electromagnetic radiation with a spectral peak of 470 nm with a radiation flux of at least 1W / m² or the power of 1 J / m² that is diffused at the surface coated with photocatalytic composition with light activated antimicrobial agents. More preferably, the invention provides a multifunctional body in which the secondary source is configured to emit, continuously or in a pulsating manner, electromagnetic radiation of 460-490 nm with a spectral peak of 470 nm with a radiation flux of at least 1W / m² or the power of 1 J / m² which is diffused at the surfaces coated by the photocatalytic composition with light activated antimicrobial agents. It is known that, in premises at high risk of infection, there are used protective layers playing the part of light-activated antimicrobial agents (LAAAs), for example based on semiconductive metal oxides. Using the secondary source according to the invention, photocatalytic activation of these protective layers takes place, thus producing an additional amount of molecular singlet oxygen species than that created by the tertiary source. This increases the effectiveness of action against pathogens by enhancing the amount of singlet oxygen acting thereon. At the same time, the secondary source according to the invention has the role of controlling the development of pathogenic microorganisms in the respective premises by radiation emission in the spectrum of 460-500 nm, which acts and activates on the membrane of microorganisms a series of photoreceptors with physiological role of triggering a series of metabolic changes, with role in inhibiting the development of nosocomial pathogens. Thus a synergistic effect is conferred by the photocatalytic activation of protective layers, combined with the action of radiation on the membrane photoreceptors of microorganisms that inhibit the growth of pathogens.

In a third aspect, the invention provides an illumination body comprising three emission sources, namely, the tertiary source and secondary source described above, and a main source. The main source includes LED emitting sources emitting electromagnetic radiation with a light flux of at least 1001m / W, providing a degree of illumination of 240lux to 80cm from the ground. The role of the main source is to provide optimal optical comfort to the user.

All of these objects provided by the present invention can be used continuously, without being harmful to a user within the premises in which they are used, and are effective for disinfecting the premises at increased risk of infection. Prior art illumination bodies to provide microbial destruction effects, emit light in 400-420 nm spectrum, with negative effects on the skin or the human eye retina. Thus, disinfection of the enclosure can only be achieved when the room is empty. On the other hand, the tertiary source according to the present invention, by using the wavelength combination as described in claim 1 , may be configured not to emit with 400-420 nm wavelengths, so that it is not harmful to humans and, at the same time, has been shown to have antimicrobial action, including antibiotic-resistant bacterial species.

Thus, the destruction of microorganisms occurs both by the synergistic action of singlet oxygen species and by radiation with certain wavelengths acting on certain membrane receptors. This results in a very effective disinfection due to the synergistic effect in the premises, with increased potential for infection. In addition, the multifunctional bodies according to the present invention have the role of lightening the premises, while providing the disinfection and control of the nosocomial agents in said premises. The main and secondary sources according to the invention can be used together or separately. Thus, the multifunctional body according to the invention may comprise a tertiary source, a tertiary source and a secondary source, a tertiary source and a main source or, a tertiary, a secondary and a main source, all these combinations providing the effects according to the present invention.

The multifunctional body according to the invention may be movable or secured to the ceiling or walls of the premises.

The invention will be further illustrated by the following embodiments which are to be considered as illustrative, but not limiting in any way the present invention, with reference to the accompanying drawings, in which:

Fig. 1 is an example of a multifunctional body for lighting and controlled disinfection having all the three sources: the main source, the secondary source and the tertiary source

Fig. 2 is a module of carying out each source

Fig. 3 is another embodiment of a multifunctional body for lighting and controlled disinfection having all the three sources: the main source, the secondary source and the tertiary source

The tertiary source can be made of an aluminum radiator to provide LED cooling. On the radiator there can be mounted 1 or 2 rows of 6 LEDs each, or 6 pairs of different LEDs, with different light emission from one LED to another. Each LED is specialized in the emission of a single light radiation from the spectral ranges of 740 nm - 780 nm (spectral peak at 760nm), 660 nm - 700 nm (spectral peak at 687nm), 620 nm - 640 nm (spectral peak at 630nm), 570 nm - 590 nm (spectral peak at 577 nm), 510 nm - 540 nm (spectral peak at 530nm), 470 nm - 490 nm (spectral peak at 477nm). A polycarbonate diffuser is mounted over the LEDs, to provide a 140° light scattering that has the function of diffusing radiation throughout the premise, to achieve the best possible disinfection.

The tertiary source thus produced can be integrated into any kind of illumination body and can be mounted in any device that allows it.

At the same time, the tertiary source can be integrated into the multifunctional body with the secondary source described below, or together with the secondary source and the main source, or only with the main source. The tertiary source can be powered separately, regardless of the secondary source and, respectively, the secondary source and the main source.

Embodiment 1 of multifunctional body with the tertiary source

It is presented the construction mode of a cassete multifunctional illumination body of the Armstrong 600x600 mm type that can be used both for lighting and disinfection, and for the control of nosocomial infections. It is mounted on the ceiling of rooms in medical facilities, which can be a ward, either AIT or pre- or post- operatory blocks, medical consulting rooms, hospital lounges, patient waiting rooms, generally in any premises where nosocomial infections are at risk of spreading and dissemination. The casettre multifunctional body with the standard dimensions of 600x600 mm is made of a plastic or metal housing such as steel or aluminum. The surface of these bodies is flat or concave. LEDs configured to emit concurrently the wavelengths are mounted thereon:

- 740 nm - 780 nm with a spectral peak of 760 nm,

- 660 nm - 700 nm with a spectral peak of 687 nm

- 620 nm - 640 nm with a spectral peak of 630 nm,

- 570 nm - 590 nm with a spectral peak of 577 nm,

- 510 nm - 540 nm with a spectral peak of 530 nm,

- 470 nm - 490 nm with a spectral peak of 477 nm.

More advantageously, each type of LED occupies a specific surface area of the LEDs total surface, as follows:

- 15% of the surface is occupied by LEDs in the 740 nm - 780 nm spectrum with a spectral peak at 760 nm

- 10% of the surface is occupied by LEDs in the spectrum of 660nm - 700nm with a spectral peak at 687 nm

- 25% of the surface is occupied by LEDs in the 620 nm - 640 nm spectrum with a spectral peak at 630nm

- 15% of the surface is occupied by LEDs in the 570 nm - 590 nm spectrum with a spectral peak at 577nm

- 10% of the surface is occupied by LEDs in the 510 nm - 540 nm spectrum with a spectral peak at 530 nm - 25% of the surface is occupied by LEDs in the 470 nm - 490 nm spectrum with a spectral peak at 477 nm.

The distribution of the LED sources implanted on the surface matrix of this body is carried out such that it provides a power density of the emitted electromagnetic radiation, i.e., the radiated power incident to the surface unit and whereat the photochemical phenomena described in the present invention are produced, to be of at least 60 J / cm² measured at a distance of 1.5 m from the emission source. This combination of electromagnetic radiation has also the effect of producing a white light that provides optimal optical comfort for the human eye.

Embodiment 2 of the multifunctional body with tertiary source

It is disclosed the way of constructing a multifunctional body mounted on a mobile stand and used to disinfect and prevent the emergence of nosocomial infections, when the situation imposes it, in the food industry, in food processing areas, in schools, on the premises of medical facilities as wards, either AIT or pre- or post - operatory blocks, medical consulting rooms, hospital lounges, patient waiting rooms, generally in any premises where there is a risk of occurring and spreading the nosocomial infections. The multifunctional cassetted body has a rectangular shape with a standard length of 600 mm, made of a metal hoeusing such as stamped steel or aluminum. The emision surface of these bodies is flat or concave.

Thereon there are mounted, in matrix, LEDs configured to emit simultaneously with the following wavelengths:

- 740 nm - 780 nm with a spectral peak of 760nm,

- 660 nm - 700 nm with a spectral peak of 687 nm

- 620 nm - 640 nm with a spectral peak of 630 nm,

- 570 nm - 590 nm with a spectral peak of 577 nm,

- 510 nm - 540 nm with a spectral peak of 530nm,

- 470 nm - 490 nm with a spectral peak of 477 nm.

- 30% of the surface is occupied by LEDs in the range of 740 nm - 780 nm spectrum with spectral emission peak at 760 nm, - 10% of the surface is occupied by LEDs in the range of 660 nm - 700 nm spectrum with spectral emission peak at 687 nm,

- 10% of the surface is occupied by LEDs in the range of the 570 nm - 590 nm spectrum with the spectral emission peak at 577 nm,

- 30% of the surface is occupied by LEDs in the range of the 510nm - 540 nm spectrum with spectral emission peak at 530 nm,

-20% of the surface is occupied by LEDs in the range of the 470 nm - 490 nm spectrum with the spectral emission peak at 477 nm.

The distribution of the LED sources implanted on the surface matrix of this body is such that it provides a power density of the emitted electromagnetic radiation, i.e., the radiated power incident to the surface unit, and whereat the photochemical phenomena described in the present invention are produced, to be of at least 60 J / cm² measured at a distance of 1.5 m from the emission source.

By using this multifunctional body with tertiary source the disinfection is carried out, and the control of nosocomial infections in hospitals and premises with increased risk of infection leads to continuous disinfection and efficient and permanent control of these premises. The advantages of using it are that it is an environmentally friendly and safe method, and the risks to humans are null, due to using of visible domain radiations that have no effect on porphyrins or nucleic acids that would cause cellular damage.

In addition to this embodiment there may be added, optionally, besides the tertiary source and the secondary source, a main source of illumination, comprising LED emitting sources, emitting electromagnetic radiation with a luminous flux of at least 1001m / W, providing a degree of illumination of 240lux to 80cm from the ground. The function of this main source of lighting is provide first of all the comfort light in the premises.

The main source of LED modules emits electromagnetic radiation whose chromaticity is perceived as a white light by the human eye, light necessary for the comfort of human activity. The main source is made of an aluminum radiator whereon 2 to 4 rows of 8 neutral, neutral-cold or neutral white LEDs each are mounted. The light flux depends on the color of the LEDs and can be at least 100 Im / W for the white color, whether neutral or cold, to provide a 240 lux surface illumination at the office level (80 cm from the ground - according to the norms in force). The color rendering index (CRI) of the LEDs must be as high as possible - more than 80, to ensure optical light comfort. Over the LEDs there is mounted a polycarbonate diffuser that provides 120° light scattering, in order to focus the radiation in the premise to achieve an adequate illumination thereof. The main source can be mounted in the housing, in tandem with other sources. The power supply is made from the control module installed in the body housing, which is independent of the other sources.

A further embodiment of the multifunctional body according to the invention comprises a metallic or plastic housing structure having a supporting role and comprising all three different types of light sources with LED modules. All three different types of LED modules emit at the same time. The construction, optical and LED features are different from one source to another, and have different functions: a main source of light emitting white light for optical comfort, a secondary source emitting radiation for photocatalytic excitation, and a tertiary source emitting radiation for stimulating microbiological photoreceptors and generate singlet oxygen species. The functioning of the illumination body described in the present invention may be continuous or discontinuous, because it uses electromagnetic radiation from the visible spectrum. The method described is not harmful to humans, inhibits the development of pathogenic germs and those which can be transmitted by air or by contact with indoor surfaces in the premises of microbiological risk.

The three different types of light sources with specialized LED modules emit independently and simultaneously electromagnetic radiation that differs from one source to another. The radiation emitted is in the visible spectrum, and is not dangerous for humans.

The multifunctional illumination body according to the invention is made of a metal or plastic housing structure that acts as an armature and supports for LED module sources. The structure can be anyone of a square, rectangular, oval shape, generally any geometric shape. Inside the housing there are mounted the activation and control elements specific to each of the three types of independent sources with LED modules. The power supply to the illumination body is made from the electrical network via a control module with a voltage regulator and provides output voltage for LEDs at 24 V (or depending on the design model, at a different supply voltage). The activation and control elements may also contain a filter to attenuate possible parasitic and overvoltage oscillations in the electrical network, and a controller and a modulation system ensure that the LEDs operate in such a way that the operating temperature does not exceed 55°C. The three types of sources (main, secondary and tertiary) are mounted in the housing of the illumination body, so that each source type works independently of each other. Each type of source with LED modules has functions, features and a construction diferent from one source to another.

Embodiment 1 of multifunctional body containing all three sources (main, secondary, tertiary)

Figure 1 shows a multifunctional body for illumination and controlled disinfection of premises at risk of infection. It is made of a metal structure chassis (1 ) which has the function of securing it on the ceiling or on the wall. It has a standard geometric square shape of the Amstrong type (600mm x 600mm). On the edges there can be added securing elements for the soffits in the false ceilings. As can be seen in Figure 1 , rectangular aluminum plates (3) are mounted on the chassis by means of a shaft (4) having a supporting role, and they can rotate about the shaft (4) which is secured to the chassis edges. The three types of independent light sources are mounted on each of these support plates: the main source (7), the secondary source (8), and the tertiary source (9). By rotating the plates (3) around the shaft (4), an optimum light flux geometry is provided, as required. As shown in Figure 2, each source is made of an aluminum radiator (5) which is fastened by the screws (6) to the support plates (3). Two LED rows are planted on the radiators, each LED being adapted to the functions performed by each source. Inside the chassis structure, the activation and control elements (2), specific to each of the three independent sources with LED modules, are mounted. The illuminating body is powered from the electrical network via a control module with a voltage regulator and which provides for output a supply voltage of the LEDs at 24 V (or depending on the design model, at another supply voltage). The activation and control element (2) is an electronic module which contains a filter for attenuating possible parasitic and overvoltage oscillations in the electrical network, and a controller with a modulation system which ensures the functioning of the LEDs in such a way that the operation temperature does not exceed 55° C. The configuration of each type of independent source is carried out as follows:

A) For the main source (7), two rows of 6 LEDs each are mounted on the radiator (5), which are all identical and emit white light. The light flux emitted by this source is at least 100 Im / W for the white color. There is provided a degree of illumination of 240 lux on the surfaces at the office level (80 cm from the ground - according to the norms in force). The color rendering index (CRI) of the LEDs must be as high as possible - more than 80, to ensure optical light comfort. A polycarbonate diffuser is mounted over the LEDs to provide a concentration of radiation of 120°. The power is provided by the control module (2) installed in the body housing and feeding a commutation module for the main source, independent of the other sources.

B) For the secondary source (8) of LED modules, 2 rows of 6 blue coloured LEDs each emitting in the spectral range of 460 nm - 500 nm are mounted on the radiator (5), and having a spectral peak at 470 nm. The LEDs mounted on the secondary source radiator can also be LEDs emitting cold white light with a spectral peak at 470 nm. The radiation flux from the secondary source is calculated to provide a minimum energy of 1 W / m² - or a power of 1 J / m²s - at the level of the surfaces it radiates. A polycarbonate diffuser is provided over the LEDs to provide a 140° radiation scattering. The secondary source is powered by the control module (2) installed in the body housing and feeding a commutation module for the secondary source, independent of the other sources.

C) The tertiary source (9) is made of an aluminum radiator (5) to provide cooling of the LEDs on which 2 rows of 6 different pairs of LEDs each, with different light emision from one LED to another, are mounted. Each pair of LEDs emits a single monochromatic radiation, which is different from that of the other LEDs mounted in the tertiary source. The spectral ranges wherein each LED is emitting are chosen from the following wavelengths of 740 nm - 780 nm (spectral peak at 760 nm), 660 - 700 nm (with spectral peak at 687 nm), 620 nm - 640 nm (with spectral peak at 630 nm), 570 nm - 590 nm (with spectral peak at 577 nm), 510 nm - 540 nm (with spectral peak at 530 nm), 470 nm - 490 nm (with spectral peak at 477 nm). A polycarbonate diffuser is provided over the LEDs to provide 140° of light scattering. The tertiary source thus embodied integrates into the illunination body in parallel with the other two sources, and is powered separately from the control module (2) installed in the body housing, and which supplies a commutation module for the tertiary source, independently of the other sources. Each of the wavelengths mentioned above acts on a single type of membrane photoreceptor, which it activates and which triggers metabolic reactions that inhibit the growth of microorganisms.

Embodiment 2 of multifunctional body containing all three sources (main, secondary, tertiary)

Figure 3 illustrates a multifunctional body model for iluminating and disinfection that can be mounted as a ceiling-mounted illumination body or in ceiling soffits and cassetted ceilings (Amstrong type), as well as on the walls. There is a model that can be used in hospitals, operating theaters, microbiology laboratories, generally in areas where disinfection is required. The multifunctional body can be rectangular with dimensions of 300mm x 600mm. The multifunctional body is made out of a chassis (1 ) of a metallic or plastic structure that has the function of securing it on the ceiling or on the wall. Within the metal structure, the power cables are run, and the activation and control elements specific for each of the three independent source modules with LED modules are mounted. The power supply to the illuminating body is made from the electrical network via a control module with a voltage regulator and provides output voltage for LEDs at 24 V (or depending on the design model, at a different supply voltage). The activation and control element is an electronic module that contains a filter to attenuate any parasitic and overvoltage oscillations in the electrical network, and a controller with a modulation system that ensures the operation of the LEDs in such a way that the operating temperature does not exceed 55°C. The three types of independent sources with LED modules: the main source (3), the secondary source (4) and the tertiary source (5) are mounted on the aluminum chassis (2) of the structure. Each type of source is mounted on the chassis by a screw fastening system (6). This ensures a geometry according to the needs of the light flux. Each source type is powered separately from the main electronic module by a controller system that provides the parameters specific to each source type. Each source is made of an aluminum support to cool and maintain the working temperature in the optimum parameters. On the aluminum support there are mounted LED chips, which are specific to each type of source. In the illumination body housing the three types of sources are mounted so as each source type work independently of each other. Each source model with LED modules has functions, features and a construction different from one source to another. The configuration of each source type is as follows:

A) The main source (3) is made of an aluminum radiator whereon 4 rows of 8 LEDs each emitting a neutral white, neutral - cold or cold colour are mounted. The light flux can be at least 100 Im / W for the white color. It is provided a degree of illumination of the 240 lux on the surfaces at the desk level (80 cm from the ground - according to the norms in force). The color rendering index (CRI) of the LEDs must be as high as possible - more than 80, to ensure optical light comfort. A polycarbonate diffuser that provides a 120° radiation concentration is mounted over the LEDs. The source is mounted in the housing, in tandem with the other sources. The power supply is carried out from the control module mounted in the body housing, which is independent of the other sources.

B) The secondary source (4) of LED modules has mounted on the radiator 2 rows of 8 blue LEDs each, emitting in the spectral range of 460 nm - 500 nm and spectral peak at 470 nm. The LEDs mounted on the secondary source radiator can also be LEDs emitting a cold white light with a spectral peak at 470 nm. The radiation flux from the secondary source is calculated to provide a minimum energy of 1 W / m² - or a power of 1 J / m²s - at the level of the surfaces it radiates. The energy of the light flux emitted by the secondary source is calculated so as to provide a sufficient number of photons per surface to initiate the photocatalytic process. A polycarbonate diffuser is installed over the LEDs to provide 140° radiation scattering. The secondary source is powered by the controller mounted in the housing, independently of the other sources.

C) The tertiary source (5) is made of an aluminum radiator to provide LED cooling, whereon there are mounted 2 rows of 6 pairs of different LEDs each, with different light emission from one LED to another. Each LED emits a single monochromatic radiation, which is different from that of the other LEDs mounted in the tertiary source. The spectral ranges emitted by each LED are chosen from the following wavelengths of 740 nm - 780 nm (spectral peak at 760 nm), 660 nm - 700 nm (with spectral peak at 687 nm), 620 nm - 640 nm (with spectral peak at 630 nm) 570 nm - 590 nm (with spectral peak at 577 nm), 510 nm - 540 nm (with spectral peak at 530 nm), 470 nm - 490 nm (with spectral peak at 477 nm). A polycarbonate diffuser is provided over the LEDs to provide 140° radiation scattering. The tertiary source so embodied integrates into the illumination body along with the other two sources, and is powered separately, as needed. Each of the wavelengths mentioned above acts on a single type of membrane photoreceptor, which it activates and which triggers metabolic reactions that inhibit the growth of microorganisms.

The multifunctional bodies of the present invention provide continuous illumination of the premise at optimal parameters, simultaneously with the disinfection caried out by the secondary source (by the synergistic effect given by the photocatalytic activation of the protective layers, combined with the radiation action on the photoreceptors of the microorganism membrane), and by the tertiary source (by the synergistic effect given by the action of the active oxygen species, combined with the action on the photoreceptors of the microorganism membrane).

Claims

1. Multifunctional body for controlled illumination and disinfection of the high-risk indoor premises characterized in that it comprises a LED-based tertiary emission source which uses several types of LEDs configured to emit, at the same time, at the following wavelengths:

- 740 nm - 780 nm with a spectral peak of 760 nm,

- 660 nm - 700 nm with a spectral peak of 687 nm

- 620 nm - 640 nm with a spectral peak of 630 nm,

- 570 nm - 590 nm with a spectral peak of 577 nm,

- 510 nm - 540 nm with a spectral peak of 530 nm,

- 470 nm - 490 nm with a spectral peak of 477 nm,

2. Multifunctional body according to claim 1 wherein the LED-based emission source is not configured to emit at wavelengths of 400 - 420 nm.

3. Multifunctional body according to claims 1-2 wherein each type of tertiary source LED occupies a specific surface area of the LEDs total surface, as follows:

- 10% of the surface is occupied by LEDs in the 660 nm - 700 nm spectrum with a spectral peak at 687 nm

- 25% of the surface is occupied by LEDs in the 620 nm - 640 nm spectrum with a spectral peak at 630 nm

- 10% of the surface is occupied by LEDs in the 510 nm - 540 nm spectrum with a spectral peak at 530 nm

- 25% of the surface is occupied by LEDs in the 470 nm - 490 nm spectrum with a spectral peak at 477 nm.

4. Multifunctional body according to claims 1-2 wherein each type of LED of the tertiary source occupies a specific surface area of the LED total surface, as follows: - 30% of the surface is occupied by LEDs in the 740 nm - 780 nm spectrum with spectral emission peak at 760 nm,

- 10% of the surface is occupied by LEDs in the 660 nm - 700 nm spectrum with spectral emission peak at 687 nm,

- 10% of the surface is occupied by LEDs in the 570 nm - 590 nm spectrum with spectral emission peak at 577 nm,

- 30% of the surface is occupied by LEDs in the 510 nm - 540 nm spectrum with spectral emission peak at 530 nm,

-20% of the surface is occupied by LEDs in the 470 nm - 490 nm spectrum with spectral emission peak at 477 nm.

5. Multifunctional body according to any one of claims 1-4, further comprising:

- a secondary source comprising LED-based emission sources configured to emit, continuously or in a pulsating manner, a 460-500 nm electromagnetic radiation with a spectral peak of 470 nm, with a radiation flux of at least 1W / m² or the power of 1 J / m² that is diffused at the surfaces coated with photocatalytic composition with light activated antimicrobial agents.

6. Multifunctional body according to any one of the preceding claims, further comprising a main source of illumination comprising emission sources based on LED emitting electromagnetic radiations with a light flux of at least 100 Im / W, providing a degree of illumination of the surfaces of 240lux at 80 cm from the ground.

7. Use of the multifunctional body according to any one of claims 1-6 for controlled illumination and disinfection of premises at high risk of infection.