UA149780U - DEVICE OF LED Ultraviolet BACTERICIDAL DISINFECTION OF AIR AND CONTAGIOUS SURFACES - Google Patents

Abstract

Device for LED ultraviolet bactericidal illumination of airspace and room surfaces, comprising housing (1), power supply contact group (2), at least one LED source of monochrome ultraviolet radiation (3), located on front face of housing (1) the LED source of monochrome ultraviolet radiation (3) contains at least one LED of the short-wavelength UVC wavelength range 220-230 nm (4), at least one LED of the short-wavelength UVC wavelength wavelength range of 275-285 nm and one (5) -370 nm (6) and at least one long-wavelength UVA LED with a wavelength of 400-410 nm (7).

Description

The utility model belongs to devices for disinfecting air, materials or objects using ultraviolet radiation. The claimed device allows for continuous, safe for the people present, bactericidal disinfection of air and contagious surfaces using an open source of ultraviolet radiation.

Prior art

It is known that in the process of infection with a coronavirus infection, the aerosol spread through the air during breathing plays a decisive role. The transmission of the virus from infected 5BAKZ-SoU-2, which occurs mainly by airborne droplets and close contact, is described in I2)І. Aerosol and fomite transmission of ZBAK5-CoU-2 is most likely because the virus can remain viable and infectious in aerosols for hours and on surfaces for up to several days.

Biological finely dispersed aerosols obey the law of gas distribution, that is, they spread in the direction of decreasing concentration. And if they are not in some local area and fill an increasingly large volume in space, then the infectious dose decreases. To get infected with the coronavirus, a certain dose is required, which depends on many factors and is strictly individual. This dependence is called "dose-effect", which is determined empirically.

However, it has not yet been possible to determine the size of the "dose" necessary for infection with the coronavirus, although the first experiments began to be conducted in Great Britain in February 2021. There are studies of infection with the influenza virus conducted on a group of volunteers. A direct dependence of the severity of the course of the disease on the concentration of viral particles inhaled from the aerosol was established. In those infected with an aerosol with a concentration of the influenza virus in the amount of 10,000 to 100,000 units, the disease occurred either in a mild form or without symptoms. For the group exposed to aerosol contamination with a concentration of 1,000,000-100,000,000 units, the disease proceeded in a severe form with complications. Recent studies |4| established a direct correlation between the amount of viral RNA

ZAN5Z-Sou-2 in the patient's blood and the severity of the course of SOMIO-19. That is, the severity of the course of the disease depends on the amount of RNA of the coronavirus in the patient's blood.

Given that airborne bactericidal aerosols and contact with infected material (fomite infection) is an important route of infection transmission, and the ability of pathogens to survive on

From metal and inorganic surfaces for a long period, the use of an expensive method of disinfection using alcohol and chlorine-containing solutions is not acceptable in the long term due to the limited period of their effectiveness. The conducted studies indicate the need for the implementation of constant continuous disinfection of particularly dangerous places - confined spaces, corridors, etc. This will reduce the concentration of the virus in the air and, if not avoid infection, then minimize its consequences. The most promising and effective proactive method of achieving the goals of creating a healthy living environment and preventing the spread of coronavirus infection is the use of continuous bactericidal ultraviolet air disinfection in combination with the disinfection of surfaces prone to the accumulation and transmission of infection in a contagious way with near and medium ultraviolet light.

SOMIO-19 raised interest in bactericidal ultraviolet (M) technologies and contributed to the emergence of a new approach to the safe use of the bactericidal OM range in the presence of people - continuous LED SHMS irradiation at very low power levels (I5). An alternative strategy of continuous disinfection in the presence of people is a new technology that solves a complex of tasks for disinfection and cleaning of air and surfaces.

Ultraviolet continuous disinfection technology implies the safe use of a source of CMF radiation in the presence of people 24/7 to continuously fight pathogens in places such as changing rooms or hospital wards and so on. The word "continuous" became a distinguishing feature of this technology from the previously accepted OMS instant disinfection. Thus, a new class of systems was formed - OMS systems with low dosage. Implementation of this type of system is possible only with the help of LEDs, unlike outdated lamps.

In the lighting industry, two possible approaches to the safe use of bactericidal range OMS in the presence of people have emerged - long-range OMS and traditional OMS at very low power levels.

Ultraviolet radiation is one of 3 types of non-ionizing radiation of the electromagnetic spectrum and is in the wavelength range from 100 nm to 400 nm.

The term "non-ionizing radiation" is usually applied to all types of electromagnetic radiation, the primary process of which interaction with matter does not lead to ionization. Because it includes electromagnetic fields and radiation with a wavelength above 100 nm, which is equivalent to quanta (photon) energies below 12.4 eV (the minimum energy required to break the weakest chemical bonds in macromolecules). The short-wavelength limit of the OM range is often considered as the boundary between the spectrum of ionizing radiation (wavelength "100 nm) and the spectrum of non-ionizing radiation. Currently, several subtypes of CM radiation are distinguished (see Table 1).

Table 1

Types of OM radiation according to IZO 21348: 2007 wave radiation, nm

In recent years, OM radiation has been used for air disinfection and purification. Global population migrations across the planet with their concentration in urbanized space have dramatically exacerbated the situation with the spread of airborne infectious diseases. Industrial and automobile emissions lead to an increase in air pollution with ecotoxicants. The OM treatment method has a number of advantages: high disinfection efficiency against a wide range of microorganisms, including those resistant to chlorine-containing compounds; absence of influence on physico-chemical and organoleptic properties of air; by-products are not formed; high speed of disinfection. Ultraviolet radiation can be used not only to disinfect water and air, that is, to remove pathogenic microorganisms, but also to decompose complex organic compounds. Currently, OM radiation is used in biochemistry, air and surface purification, etc. A direction based on bactericidal action received special development

OM radiation. The energy of ultraviolet quanta is sufficient to destroy biological molecules. One of the methods of destroying microbial pathogens is based on this. The bactericidal efficiency curve shows that only a narrow range of 230-300 nm, i.e. approximately a quarter of the entire ultraviolet range, has a clear bactericidal effect. Quantums with wavelengths in this range are absorbed by nucleic acids, which leads to the destruction of the structure of DNA and RNA. OM-irradiation disrupts the structure of DNA or RNA - just one picosecond is enough for the formation of a dimer. In most cases, dimerization occurs between two pyrimidine nitrogenous bases, thymine in DNA or uracil in

RNA, but cytosine dimers also occur. Purines are also able to absorb CM radiation, but pyrimidines have a tenfold absorption, and in practice, among all photoproducts, dimers

Thymine is found most often. In addition, in some pathogens, especially viruses, ultraviolet radiation can be absorbed by proteins and form bonds between proteins and

DNY/RNA, which can also lead to death.

Scheme of destruction of the genome by XM-radiation (see Fig. 2) demonstrates the dimerization reaction of thymine (shown in purple), which is stimulated by UV radiation, and the distortion of the DNA chain as a result of the reaction. The reaction can be reversed by photoreactivation.

In addition to being bactericidal, i.e. killing bacteria, this range has virulicidal (antiviral), fungicidal (antifungal) and sporicidal (kills spores) effects. The effects caused by OM irradiation depend on the wavelength of the radiation or its spectral composition (see Fig. 3).

The action spectrum is a graph of the reciprocal of the energy exposure required to obtain a bactericidal and/or virulicidal effect for each wavelength. All data on such curves are normalized to the results for the most effective wavelengths. In order to cause any change, OM radiation must be absorbed by an organic molecule.

This process involves the absorption of a single photon by a molecule and the achievement of an excited state in which one electron absorbed by the molecule moves to a higher energy level. Primary products formed under the influence of ultraviolet radiation are usually highly active particles or free radicals.

The spectral sensitivity of a microbe is the relative ability of a microbe to absorb a photon as a function of a range of wavelengths. In the bactericidal range of the PMS, maximum disinfection efficiency is achieved with maximum absorption of DNA/RNA radiation, while outside this range, the efficiency of longer or shorter wavelengths begins to drop sharply

IBI (see Fig. 4).

A study of these pathogens, i.e. prokaryotic (bacterial) cells, E. soya and MEA5A, eukaryotes (protozoa) such as Sturio (Sturiozorogidit), and a common virus such as rotavirus, shows that each has a unique range of radiation absorption .

In other words, they absorb photons at different wavelengths differently depending on their physical biology. Although each pathogen is different, each pathogen exhibits a peak absorbance around 265 nm that rapidly decreases above 280 nm in the range

OMV For most pathogens, there is a sharp drop in sensitivity below 250 nm - for this reason, the range from 250 nm to 280 nm is usually called the range of bactericidal CM radiation. The main way in which OMS inactivates the pathogen is by creating dimers of thymine in cellular DNA, the peak absorption of which is 260 nm. Disinfection effect of CM radiation is achieved due to splitting of chemical bonds between nucleic acids in the DNA of a virus or bacteria. Thanks to this, DNA cannot be duplicated during cell division. This DNA damage depends on the wavelength of the radiation source and the effective dose. However, as shown in Figure 3, the observed absorption peak and intensity differ between different microbes. This difference results from the cellular protein structure, specifically the presence of aromatic amino acids such as tryptophan and tyrosine, which have an absorption peak near 280 nm. Cells with more or less of these proteins effectively shield nucleic acids and shift the spectrum from 260 nm to 270 nm, with 265 nm being the most frequently observed peak. All shifts and effects occurring in the irradiated

OM-rays of the body - photoerythema, pigmentation, desensitization, bactericidal effect, etc., has a clear spectral dependence (see Fig. 5), which is the basis of the differentiated application of different sections of the OM-spectrum I7|.

The bactericidal and mutagenic effect of ultraviolet radiation needs to be established

TIM (Togezpoiy (it Mashe god ShpPgamioiei Naidiyop - the threshold value of the limit for ultraviolet radiation) for exposure to SHMS, in order to avoid skin damage and injuries to the eyes, which are most sensitive to the action of ultraviolet light. Due to different energies and potentials, the function of TIM changes with the wavelength of OMV (see . Table 2). TM is supported by the International Commission on Non-Ionizing and Radiation Protection and is used in establishing lamp safety standards. In the European Union, the concept of permissible dose of OM-radiation or TIM equal to 30 J/m- is used to assess the degree of exposure.

Table 2

Значення спектральної бактерицидної і мутагенної ефективності ОМВ нин зжинининнншишиишишиииих :нишии 11112451 Ї777171717171717171711106677777777 17717171 036СсСщС 1215 Ї7771717171717171717171710877777777717177717171717171717111096СсСсСщС

Table 2

Value of spectral bactericidal and mutagenic efficiency of OMV 11110805... ..Юююююююююююоол0006777777777Й7771717171717171717111006СсСщС nin zhi p: po PO Zh t ho

Exceeding this dose is considered potentially harmful to health. Regulation of this norm is carried out within |8) (see Table 3).

Table C

Norms of Directive 2006/25/EC

Wavelength Limit Radiant radiation,| value exposure Body part Danger of nm exposure IJ/m21 photokeratitis

Day cornea of the eye, and conjunctivitis 180-400 values Nek-30 mucous membrane of the eyes, | cataractogenesis

OMA, MV, OMS 8 hours (3.0 mJ/cm?) | lens of the eye, erythema skin, squamous cell carcinoma of the skin

Large doses of XM radiation can cause damage to the eyes (photoophthalmia). The eye is most sensitive to damage under the action of OUM radiation in the lower band of the SMS at 250-275 nm. To a lesser extent, radiation with a wavelength of 280-300 nm can also cause photokeratitis (damage to the lens, cornea and retina of the eye).

Irradiation of the skin with UM in sufficiently high doses causes erythema or skin burns. Frequent and excessive doses of CM radiation in some cases can have a carcinogenic effect. The spectrum of the erythematous action of CM radiation has a maximum at 297 nm and a deep decline around 280 nm with increasing efficiency with further reduction of the wavelength.

OM radiation with a wavelength of 296.7 nm has the maximum erythema effect (see Fig. 5).

The spectral composition of ultraviolet radiation, which causes a bactericidal effect, lies in the wavelength range of 205-315 nm, and the relative spectral bactericidal efficiency 5 (АХ) rel., which depends on the wavelength of X radiation, has a peak value at A-265 nm. According to the latest data (|9| This wavelength corresponds to the maximum bactericidal effect (see Fig. 6, Table 2).

Ultraviolet bactericidal air disinfection is an engineering method used to control the airborne transmission of pathogenic microorganisms in high-risk environments. Despite the relatively recent appearance of respiratory viral pathogens, such as BAKZ, avian influenza viruses, ZAK5-Sou-2, etc., OM disinfection of pathogenic viral aerosols has not been studied enough. Because of the relative novelty of BAK5-SoMu-2, impact studies

OMs for the coronavirus appeared relatively recently, and before that they were practically absent. The spread of infections caused by the novel coronavirus disease SOMIO-19 throughout the world has raised concerns about the prevention and control of 5BAKZ-SoUu-2. Devices that rapidly inactivate viruses can reduce the likelihood of transmission through aerosols and contact transmission. Therefore, when developing them, you should refer to the developments obtained during the struggle with

BAN, and then with MEK5, which are representatives of the same family as BAK5-Sou-2.

ERA (Piveid 5iaies Epmigoptepia! Rgoiesip Adepsu) uses a logarithmic scale to measure the effectiveness of UM light in neutralizing pathogens such as coronavirus (10).

The lowest on the scale is I0d-1, which kills 90 95 live bacteria, but does not kill such small viruses as the coronavirus. The highest level is I0d-6, which kills 99.9999 95 pathogens, including the coronavirus (see Table 4).

Table 4

Logarithmic scale

In the article (11), the activity of hard ultraviolet was tested against viral aerosols, that is, the same particles with which the virus lives in the environment and enters our lungs. The coronavirus is a type of positive-polar single-stranded EMU virus, just like viruses

ZAKO and MEK5. Studies have shown that this type of virus is sensitive to heat and ultraviolet radiation and weakens when the intensity of ultraviolet radiation is higher than 90 μW/smg-. Thus, ultraviolet radiation can destroy the coronavirus (ZAK5-SoMu-2). To destroy single-stranded RNA coronaviruses, a dose of 339-423 μWhs/cm2 of ultraviolet radiation with a wavelength of 254 nm is required, which provides 90-95 air disinfection (12). The time of destruction of the OM virus by the lamp depends on its power and usually ranges from 2 to 15 minutes |I13). Article (14|) is a guide for choosing the power of radiation to combat coronavirus. In it, the authors evaluated the effectiveness of the effect of hard bactericidal ultraviolet light on viral aerosols with different types of nucleic acids. Considering the fact that ZAKZ-SoM-2 contains single-stranded RNA, for its inactivation requires a dose of MS radiation at the level of 192-240 μWhs/sme when using 280 nm radiation, which is safe from the point of view of mutagenic action. However, the authors of I14) noted the role of humidity and its effect on the intensity of virus disinfection, which is determined by the susceptibility coefficient, which was higher at 55 95 humidity than at 85 95 humidity, possibly because at increased humidity, water sorption on the viral surface may protect DNA or RNA from OM-induced damage.

Single-stranded RNA viruses ZAK5Z-Som-2 (15) are less resistant to OM radiation than double-stranded ones due to the lower stability of the I16Y genetic material. In (171) summarized the data on CM-inactivation of various coronaviruses, calculated the average dose of Id reduction, which was equal to 11.9:211.4 mJ/cm:? for all coronaviruses. However, the authors assumed that the adjusted dose is 5.8245.5 mJ/cm", which is also effective against BAK5-Sou-2 due to the structural similarity of all coronaviruses. In practice, an experiment (18| showed that a dose of 3.7 mJ/cm? is the minimum threshold for destroying this virus. Similarly, |19 | achieved complete inactivation of the virus after 9 minutes of exposure to CM radiation with an intensity of 1.94 mW/cmg ОМС and 0.54 mW/cmg ШШМА. Thus, the effectiveness of CM radiation against

Ko) of the pathogen SOMIO-19, BAN5-Som-2.

In the early studies on the application of CM radiation for the purposes of disinfection, traditional sources of radiation - low-pressure mercury lamps - were used. However, traditional OM lamps have several limitations that prevent their use for direct, continuous disinfection purposes in the presence of humans. Among these limitations, the weak radiation intensity at low temperatures, the long warm-up time before entering the operating mode and the risk of exposure to mercury are critical. UM-radiation lamps emit only with a wavelength of 254 nm, therefore, as an alternative, OM-light-emitting diodes were proposed, which can emit at the wavelength of the required range. The paper (20) studied the effectiveness of inactivation of pathogens by CM-light-emitting diodes with wavelengths of the OMS range, which was compared with the results obtained with ordinary OMS lamps. Selective Wednesday contained

Ezspegispia soii 0157: H7, ZaItopeia epiegisa zegomag Turpitigicht, and Hyetegia toposuiodepez and was irradiated with OM-light diodes with wavelengths of 266, 270, 2751279 nm and 01, 02, 0051 0.7 mJ/cm: respectively. The emission intensity of the CM-LEDs was about 4 W/sme, and the OM-lamps were covered with a polypropylene film to adjust the light intensity to the level of the intensity of the CM-LEDs. Studies have shown that the rate of inactivation of pathogens after treatment with OM LEDs significantly exceeded that for CM radiation from a lamp with comparable intensity. For sliced cheeses after treatment there was a decrease of 4-5 logarithms at C mJ/cm: for all three pathogens. The authors established that the use of CM LEDs is an innovative and effective technology for decontamination of food pathogens.

In order to combat the spread of airborne infections, the results of research into the effect of LED CMS irradiation on the inactivation of viruses and other pathogens are of interest. Thus, in the article (21) an evaluation of the antiviral effectiveness of irradiation using VOM-I EO, which generates a narrow wavelength (2805 nm), was carried out, which was tested against the ZAKZ-SoM-2 virus. The strain 5BAKZ-SouU-2, isolated from a patient, in from which SOMIO-19 developed on the Oiatopa Rgipse55 cruise ship in Japan in February 2020 was obtained from the Public Health Institute of Kanagawa Prefecture (5AK5Z-Som-2/NshSHOR/Kpa/19-027, 1 C528233). All experiments were performed in the B5I-3 laboratory.

It was established that short-term irradiation of BIOM-SEYUO quickly inactivated ZAKZ-Som-2.

A decrease in the infectious titer to 87.4 9o was detected when the viral material was irradiated for 1 s, and when irradiated for 10 s, the infectious titer decreased to 99.9 95. These results show that OSHM-IGH EO radically inactivated BZAK5-Som-2 using exposure even for a very short time.

In the paper (221), the authors also showed that the new promising technology of CM-light-emitting diodes can be used for the inactivation of pathogens. However, UM LEDs with a short emission wavelength are still relatively expensive, have a low energy density and a short service life.

It was established that the sensitivity of the human coronavirus (HSoM-OS43, which is used as a surrogate for ZAK5-Sou-2) to inactivation depends on the wavelength and decreases in the order of 267 nm - 219 nm » 286 nm » 297 nm. Other viruses showed similar results. It is assumed that M LEDs with a peak emission at "-286 nm can serve as an effective tool in the fight against human coronaviruses.

MISNIA has demonstrated that modern OM LEDs with an emission wavelength of 280 nm provide higher virulicidal efficiency because they actually have a more intense emission compared to other unsubstantiated claims on the market.

Indeed, the data emphasize that the virulicidal efficiency of the 280 nm LED is about 1.3 times (at "- 27 9o) higher than that of the 265 nm LED (231.

Importantly, with the current state of the technology, the lifetime of a 280 nm LED is ten times longer than that of a 265 nm LED. In tests that compare the MISNIA 280 nm OMS LED solution with a randomly selected competitor that offers

From OMS 265 nm, the light flux intensity of the first (9295 after 4000 hours) differs favorably from the second (67 95 under the same conditions). Thus, at the moment, the 280 nm solution remains the most optimal offer on the market (see Fig. 7).

The work (24) studied the influence of the state of the environment on the processes of surface inactivation by small doses of UV light irradiation with LEDs. It is believed that irradiation with deep ultraviolet LEDs (VOM light-emitting diodes) becomes an effective low-energy, chemical-free approach to reducing microbial contamination, but the influence of surface conditions on the effectiveness of inactivation is insufficient studied. Inactivation of H. ipposca and E. soya ATOS25922, as model gram-positive and gram-negative bacteria, respectively, was carried out using a 280-nm UV light-emitting diode. Surface treatment environment scenarios commonly found in environmental, clinical, or food industries , differ in the presence on the surface, for example, of stainless steel, of thin liquid films rich in nutrients.

Dry and wet surfaces were studied. Under the influence of OUM GEO for both scenarios, a 5-logarithmic reduction in 10 min (or 23.8 mJ/cm2?) of pathogen concentration was achieved. The kinetics of inactivation in thin films and on the dry surface of stainless steel followed the Weibull model (0.96 x K2 x 0.99). But the model overestimated the inactivation of a small dose of BOM on a wet surface of stainless steel. Microscopic studies have shown that bacteria form a dense outer layer in the liquid and at the boundary between the air and the liquid droplet, which protect the cells inside the droplet from the bactericidal OM. This resulted in lower than expected inactivation on the wet stainless steel surface at low doses of PTO and showed a deviation from the model

Weibull. Moreover, it was proved here that the aggregation of bacterial cells at the liquid-air interface, caused by both thermodynamic factors and mobility factors, protects cells inside liquid droplets from bactericidal OM, thereby slowing down the initial stages of inactivation. In this study, it was shown that exposure to low-intensity 405 nm light after the VSHOM procedure provided permanent suppression of reactivation.

From this point of view, the work (25) in which the influence of the synergy of OMA and SHMS radiation (365 nm/280 nm) on inactivation processes in liquid media was studied is of great importance. Combination of MA and

OMS ensures microbial decontamination of the environment more than when using only one type of OMS. Moreover, only the synergy of 280/365 nm allows to significantly reduce the level of the number of mesophilic bacteria. The synergy of UM radiation with wavelengths of 280 and 365 nm reduces the content of pathogens in proportion to the exposure time, and also oxidizes organic pollutants up to 37 to creatinine and phenol. Table 5 shows the doses of SHMS irradiation sufficient to neutralize some pathogens according to research data that do not raise questions about research methodology.

Table 5

Radiation doses according to research data penyu reeenny TKU otseynny no ven "| Source Pathogen Environment) waves, and Goa mJ/cm"(given n/p irradiation Z nm to A-280 nm) prmdneyunii de | TO 1 (2O) E. soybean O157:H7 279 2 3.46 600 s C 4.04

E. soy apa dry z00s A 149 2 (24 G. hippopotamus, surface 280 vo s 5 23.8 liquid 1s 0.9 3.75 (BAN5-Som- 10 s C 37.5

З (211 2/NySHOR/Kpa/19- 280 20s 23.3 75 027.1 0528233 З0s 23.3 112.5 boss »3.3 225

NSoU-OS4Zaz |. 279 viral 60 s Z 6-7 cytodaiie 55AMA M52 migi5 surface 1 0.68-2.14 550MA migiv (rni suspension 1 6.84-13.67

HT хХ174) surface 253.7 1 1.42-2.57 а5зАМА (rnpi 6) 1 2.16-3.05 а5zoMA мигив (17 1 4.39-4.63 558МА М52 миги5 55ОМА мигив (р | BO ov pa4g хХ174 ) aerosol 253.7 4 0377-0492 a5AMA (rpi 6) and 0.518-0.682 a5zoMA migiv (17 ' ' x Dose for activation 99 95 (I0d2) twice higher 5

These works provide insight into how to select the parameters of the LED treatment of OM to achieve effective inactivation during disinfection of both air and biotic and abiotic surfaces. At the same time, the use of the OMA range during bactericidal treatment also has prospects for cases of disinfection of premises in the presence of people.

Work (26) shows that OMA in moderate doses can be safe for use in the presence of people. OMA light at a wavelength of 365 nm has antimicrobial activity against pathogens such as EbsPegispia soii and Sapaida aibisapv5, and leads to a slight reduction of vegetative microorganisms and reduces the recovery of pathogenic bacteria. In connection with the fact that the disinfecting action of CM radiation has an accumulative effect, the time of irradiation is important from the point of view of photobiological safety. OSHMA rays are the reason for the development of photosensitivity. Most dermatoses associated with increased congenital or acquired sensitivity to ultraviolet light are aggravated by exposure to the long-wave spectrum. Their range is different for individual dermatoses: photodermatoses - wavelength 290-365 nm; porphyria - wavelength 400-410 nm; solar urticaria - range: 290-515 nm. In this regard, on the basis

Standard of the International Electrotechnical Commission IES) and the International Commission on Illumination (IEE) (27 | established a safe dose of 30 J/m2 with a regulated duration of exposure of 8 hours, which corresponds to the illuminance threshold of 10 W/m for near ultraviolet (315-400 nm) or 0.0011 W/cm2 for language-weighted actinic coefficient The Lighting Research Center (RCC) at Rensselaer Polytechnic Institute has announced the results of research on the use of continuous disinfection technology based on ultraviolet OM LED radiation in a hospital-tested HMA strip, which, as was have been shown to kill pathogens on surfaces after eight hours of exposure in a hospital intensive care unit. Tests also revealed that UV radiation also caused photodegradation effects in rooms (28). An earlier paper (291) discussed the technology of Miobzaite MUpiie Gdni rezyptesiop of the firm Mine!Mio which uses 405nm LEDs together with white LEDs for bactericidal treatment of rooms with people.

The manufacturers stated that their technology allows to neutralize 90-95 bacteria during the day. However

MiiaI Mio is not the only company that uses such technologies of continuous disinfection. Kepai!

Mapygasiigipd has a line of lamps called the family of continuous disinfection

Ipaido-Sieap. Clean continuous disinfection 405 nm visible light system from Kepaia

Mapiitasishipud kills microorganisms to disinfect air and surfaces in clinical environments, helping to reduce cross-contamination from different rooms and procedure areas. In studies, the disinfection technology demonstrated 86 95 efficiency, going beyond current cleaning protocols.

ISOI's patent states that visible light, which has a wavelength of 405 nm, is not only capable of effectively destroying bacterial, viral, microbial cells, etc., but is also harmless to the human body. Visible light, which has a wavelength of 405 nm, has superior sterilizing effect against various germs, bacteria, viruses, etc., such as salmonella, pneumococcus, coronavirus, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Light with a wavelength of 405 nm is able to sterilize surfaces without harming the human body, unlike the problems associated with ultraviolet light. However, a large amount of energy is required to induce porphyrin-reactive decomposition using visible light with a wavelength of 405 nm. For this reason, the conventional sterilizing device using visible light with a wavelength of 405 nm has the problem that the active sterilization distance is not long, and therefore it is only possible to perform short-distance sterilization, and it is difficult to perform it in the case of long-distance sterilization. However, the question of the effectiveness of direct OMA irradiation is quite controversial, because there is not enough evidence regarding the necessary dose that would be sufficient to neutralize pathogens on surfaces to achieve a bactericidal effect (311.

In work I32| found that low-intensity 405 nm light irradiation (0.035 mW/cm) resulted in a total of 55.08 95 inactivation of ZAK5-Som-2 after four hours and a total of 90.17 95 inactivation after 24 hours. A higher dose (0.076 mW/cm?) resulted in 98.22 95 inactivation after 24 hours, while an irradiation dose of 0.150 mW/cm- showed a decrease of 63.64 95 and 99.61 95 after 4 and 24 hours of exposure, respectively. Finally, increasing the dose to 0.6 mW/cm2 gave 99.74 95 after eight hours, indicating the dependence of the inactivation of ZAK5-

Sou-2 both by time and by dose.

To confirm this effect, the influenza A virus was used, which is another human respiratory virus with a lipid envelope and an RNA genome. After irradiation for 1 hour at 0.6 mW/cm2, a total decrease in the content of influenza A virus by 31.11 95 was observed, compared with a decrease of 71.52 95 for BAK5-SomM-2 under the same conditions. Although both viruses have lipid envelopes, there is clearly a difference, possibly due to the difference in virion size, which creates a physically smaller cross-section for absorption (IAM - 120 nm and BAK5Z-bomu-2 - 200 nm). However, both viruses were largely inactivated after eight hours - 98.49 95 for IAM and 99.74 95 for BAK5-CoM-2. The obtained results suggest that the action of visible light against BZAK5Z-Sou-2 is similar to the action on organisms commonly found in the environment, such as 5. acgei5. Previous studies have shown that the levels of visible light radiation used in this study (from 0.035 mW/sme to 0.6 mW/cm-) reduce bacterial levels in crowded spaces and improve surgical outcomes. Therefore, it is reasonable to conclude that visible light can be an effective disinfectant against ZAKZ-SoU-2. More importantly, this disinfection can work continuously because it is safe for humans according to the exposure guidelines in IEC 62471. Table 6 shows the doses of OMA exposure that are sufficient to neutralize some pathogens according to studies that do not raise questions about the study methodology.

Table 6

Radiation doses according to research data

Length Time o Dose, 4 hours. 55.8 95 504 8 h. 90.17 96 3024 7 IZ2I | ZAN5-Som-2 405 24 hours 98.22 96 | 6566 24 hours 99.61 965 | 12960 8 hours 99.74 6 | 17280

Epivegosossiz of Taesai in, | dry

YZT| |Ev5sPetpisnia soy surface 365 8 h. 90 o'clock 8600 ziarpuiosossiv ashgeiv

Epivegosossiz Taesaiyi5 38 9o

IZ2| | iarpuiosossiv aigeiy5 365 8 h. 98 95 8600

EzspPegispia soii 82 9 Tue 1 4320 24 h. 1.5 8640 10 (331 ziarpuosossiv aigeiv5 365 4 h 1.7 25900

M52 migi5 365 8 h. 1.5 4320 24 h 1.6 8640

And 2 25900

In the work of IZZI, which is the basis of the product 365OizipEx" | VO 134), the antibacterial efficiency of 365 nm LEDs is shown. It is shown that exposure to ultraviolet light (OMA) with a power of C W/m2 for 4, 8 and 24 hours, with doses of 4.32x103 , 8.64x103 and 2.59x104

J/m-, respectively, leads to a moderate decrease in the recovery of methicillin-resistant bacteria, such as Ziarpuiosossi5 atsgei5 (MK5A), Sapaida atsgie, Basiegiorpade M52 and Rasiegiorpade Rii X174. These results indicate that OMA may be useful as a means of providing continuous low-level radiation for the purpose of decontamination of surfaces in healthcare facilities. OMA radiation in the room should be less than 1 W/m? within 8 hours (DSTU EM 62471: 2017), which corresponds to the maximum dose of 1x8x3600-28,800 J/m7. Therefore, the recommended dose of OMA radiation can effectively inactivate fomites.

Recently, a number of publications have appeared on the bactericidal effect of ultraviolet radiation in the long range of 207-222 nm (IZ5). A direct approach to prevent airborne transmission is the inactivation of airborne pathogens using bactericidal ultraviolet light, but its widespread use in public settings is limited because conventional sources

OMS of light are both carcinogenic and cataractogenic, although according to data (|С6| it is concluded that the UV radiation of low-pressure mercury lamps in itself does not cause cancer.

Bactericidal OM irradiation can be safely and effectively used to disinfect the upper layers of the air without significant risk of long-term delayed effects such as skin cancer. In contrast, OMS light of a long range (207-222 nm) effectively kills bacteria without harming the exposed skin of mammals. This is due to the fact that, due to its strong absorption by biological materials, the light of this range cannot penetrate even into the outer (inanimate) layers of the human skin or eye; since bacteria and viruses are micrometers or smaller in size, far-field CMS light can penetrate and inactivate them. In the work, it is proved that the far OMS light effectively destroys viruses in air aerosols. Even a very low dose of 2 mJ/sme, 222 nm light inactivates » 95595 NIMI influenza virus. Continuous ultraviolet radiation at very low doses in public spaces is promising,

With a safe and inexpensive tool to reduce the spread of airborne microbial diseases.

The far OMS range is represented by excimer lamps manufactured by O5pio. This method uses the bactericidal potential of radiation with a wavelength of 222 nm.

Integration of O5Pio modules into ordinary general lighting ceiling lamps under the Sage222 brand |37)| is envisaged. The production of such devices is carried out by a number of companies.

The only significant drawback of these solutions for the use of a gas mixture of krypton chloride is the need for forced cooling of the lamp bulb. In this regard, Me Mapoiespy Zpohim/amehidnitm emitters are of interest - the world's first solid-state products emitting short-wave ultraviolet light in the far OM range of 200-230 nm.

Unlike standard M lamps, which operate at high temperatures and require the use of caustic gases, ZpogpiuMameGidni mm solid-state emitters do not heat up during operation, are small enough to be integrated into portable desktop devices, and do not use hazardous gases.

Commercially available SHMS LEDs are based on semiconductors made from AI/-xbM alloys, and the emission wavelength is controlled by their composition, which means that USSHMS LEDs can also emit at wavelengths below 225 nm, including 222 nm. A higher mole fraction of AI is required for the emission of SHMUS LEDs at these shorter wavelengths, which leads to lower efficiency. For example, today commercial MC LEDs Sguzia! I5 is approximately one order of magnitude (factor of 10) more efficient at 265 nm than at 230 nm, and two orders of magnitude less powerful; at wavelengths below 225 nm are expected to suffer further degradation in efficiency and power. Thus, for the vast majority of pathogenic microorganisms, the level of disinfection achieved will be much higher in the bactericidal range when using today's LED technology MS |401.

As shown above, SHMS radiation is the most effective for inactivating viruses. However, with an insufficient dose of radiation, only partial damage occurs, pathogens can recover by recombination and acquire resistance to the primary dose of radiation (41). Most organisms have a genetic mechanism for self-repair, so OM decontamination systems must deliver a sufficient dose of UV to overcome their defenses and prevent replication.

ISMIKR I53| issued a manual on professional OM exposure, in which, according to SMS exposure, it is stated that when OM radiation is exposed to unprotected eyes/skin, the energy exposure should not exceed 30 J/m2 at a wavelength of 270 nm, i.e. the peak wavelength of the spectral weighting function for actinic hazard UM radiation for skin and eyes.

Since the dangerous effect of CMM radiation depends on the wavelength, for radiation with a wavelength of 254 nm, the maximum permissible exposure is 60

J/m7. For radiation with a wavelength of 222 nm, the maximum permissible exposure

Zo (actinic danger of OM radiation) is even higher - approximately 240 J/m", and for radiation with a wavelength of 280 nm, the maximum permissible exposure is 75

J/m-, which is equivalent to a dose of 7.5 mJ/cm: or a radiation intensity of 0.26 μW/cm.

DSTU EM 62471: 2017 recommends that the OM radiation in the room should be less than 0.1 μW/sme for 8 hours (for a wavelength of 270 nm). Therefore, the recommended dose of OMS radiation can effectively inactivate an airborne virus.

Also known is the technical solution of ZtsChapddopud Gopushpo Gay Gidbipud Co., (a. I42 | model

ZRI 600, in which, along with the general lighting lamp, an ultraviolet module with ShMS (275 nm) and OMA (405 nm) LEDs is used in equal quantities. The latter indicates the lack of regulation of the radiation power in accordance with the standards of photobiological safety and exposure to blue light - dangerous for the skin and retina. Therefore, the lamp has additional sensors that make it possible to use it in rooms in the presence of people.

There is a solution 365b0i5IpEx "m | EO I utipaiiige5 AMO 5eigpez-365B0i5IpEx"M OMALLAINne I EO I ipeag

Ipaiviya! (43). The 3650i5IpEx"m OMA series linear industrial LED luminaires offer efficient overall lighting characteristics, with significantly greater capabilities. In addition to high efficiency for light industrial and general applications, the AMO series also offers 365bi5IpEx"m OMA technology that aids in the inactivation of surface bacteria where people are present, and general purpose lighting is required. The 365bi5Ipex "mM OMA disinfection technology uses OMA LEDs emitting at a wavelength of 365 nm. It is stated that irradiation with a power of 3 W/m? during one 8-hour period will lead to a reduction of MEK5BA by 99.7 96 on the affected surfaces OMA: The main drawback of this decision is the impossibility of its application in the case of inactivation of viral aerosols.

There is a solution of 3650i5IpEx OMS of the same company, testing of which with bacteriophage M52 resulted in 88 95 inactivation of the aerosol virus in a room measuring 3 by 3 by 2.4 meters for 4 hours. Test results during 24-hour continuous operation 3650i5Ipex M

IRO showed the inactivation of M52 bacteriophage up to 4495 in 2 hours. The manufacturer predicts equivalent or better results for seasonal coronaviruses and 5AKZ-SoUu-2. With proper installation and adjustment, the continuous operation of the 3650izIipEx"m |RO should provide 50 95 inactivation in the first hour of exposure, 90 95 inactivation (1 I0d) in 3 hours and 99 95 inactivation (2 units) after 6 hours or less exposure. SE Sigepi continues to conduct further validation tests.LEDs are used in this solution

MS range and to achieve a positive effect, the manufacturer recommends using the solution 3650bi5IpEx m | RI and 3650i5IPE MAMAs at the same time (441.

In U.S. Patent No. 45, issued to CE Gidypud Zoishiop5 GIS, Eazi CiimeIapa, ON (05), and under which the above products are manufactured, the illumination system includes a light source configured to generate light to one or more surfaces or materials to inactivate one or more pathogens on one or more surfaces or materials.

The light includes an inactivating part having wavelengths in the range from 280 nm to 380 nm. The kinetic dependence or relationship between the energy of photons of light and the rate of inactivation is used as the main model on which the use of the lamp is built. At the same time, it is concluded that a 10-fold increase in the inactivation rate is observed when the photon energy increases by 0.27-0.44 eV. Although this is possible within the near OMA range and indeed to achieve a 1 Iod inactivation effect for 405 nm (3.06 eV) compared to 370 nm (3.33 eV), the important thing is that the power consumption in this case will be only 10 95 of power consumption for the case of a wavelength of 405 nm. This does not take into account the mechanism by which inactivation is implemented at different wavelengths of OM radiation and, accordingly, the purpose for which this or that OM range is used.

A device for reducing the number of microorganisms in food products is also known

I46Y, using a combination of infrared light and visible light, wherein the device contains one or more LED elements, wherein the LED elements consist of one or more LED elements emitting infrared light with a wavelength in the range from 930 nm to 960 nm, one or several LED elements emitting visible light with a wavelength in the range of 425-465 nm, and one or more LED elements emitting visible light with a wavelength in the range of 600-620 nm, while the number of LED elements emitting light from 425 nm to 465 nm, more than the number of LED elements emitting light of 600-620 nm.

The use of LEDs in this solution is positive, but insufficient from the point of view of the effectiveness of disinfection and the possibility of neutralization of pathogens on the surfaces of objects and in the air.

Ko) As the closest analogue, a portable two-band OM LED bactericidal lamp I47)Y was chosen, which contains an aluminum board with two-band OM LEDs, a radiator and an aluminum grid. The board is placed in the middle of the grid and equipped with LEDs of the OMA range with a wavelength of 395-420 nm and LEDs of the ShMS range with a wavelength of 255-285 nm.

The main drawback of this device is the lack of LEDs of the long-wavelength OMA range with a wavelength of 360-370 nm, and as a result, insufficient antibacterial efficiency.

Similar devices for LED ultraviolet bactericidal disinfection of air and contagious surfaces have not been found.

The basis of a useful model is the task of creating a device for constant, fast and effective disinfection of air and contagious surfaces in rooms through which pathogens of infectious diseases can be transmitted. At the same time, the provisions given above should be taken into account, namely: the ZAKZ-SoM-2 virus binds to the receptor of human cells with the help of the spike-like 5-protein (5rke rgoiveip)u. The spike-like 5-protein, fixed in the envelope of the coronavirus, is a three-dimensional acute glycoprotein |48)І. In view of recent reports of mutations in the coronavirus, which occur mostly in the 5-protein, and which reduce the effectiveness of existing vaccines (49), the most reasonable approach to inactivate the coronavirus is destruction of the 5-protein by ultraviolet radiation. Given the fact that enveloped RNA viruses make up the vast majority of the pathogen population, this approach is the most promising in the prevention of airborne diseases.

Far OMS light effectively destroys viruses in air aerosols. Even a very low dose of 2 mJ/sme, 222 nm light inactivates » 95 95 NIM1 influenza virus. Continuous ultraviolet radiation at very low doses in public spaces is a promising, safe and inexpensive tool to reduce the spread of airborne microbial diseases.

Irradiation of the SUS LED with a wavelength of 280 nm radically inactivates the BAK5-bom-2 virus within a very short time using doses up to 37.5 mJ/cm7. A decrease in the infectious titer to 87.4 95 was detected when the viral material was irradiated for 1 s, and when irradiated for 10 s, the infectious titer decreased to 99.9 95.

Human adenovirus (a DNA virus) shows a relatively high inactivation efficiency at 280

Nm. This is due to the fact that the CM absorption of the protein has a relative peak at about 280 nm, and because protein damage plays an important role in the inactivation of the adenovirus.

Ultraviolet plays an important role in providing the body with vitamin O, which regulates the process of phosphorus-calcium metabolism. Vitamin O deficiency reduces immunity and causes rickets and caries. The spectrum of the effect of the SHM for the synthesis of vitamin OZ is similar to that of erythema and has a maximum at a radiation wavelength of 280-290 nm. The dose of OM radiation to open areas of the body required to compensate for vitamin O deficiency is 60 minimum erythema doses per year.

OM radiation affects the decomposition of products of photochemical reactions and harmful gases. The decomposition of phenol is most effective at a wavelength of 280 nm, and therefore OM LEDs are promising for cleaning the environment from decomposing organic compounds and other products of photo-chemical reactions.

The combination of OM and MS ensures microbial decontamination of the environment more than when using only one type of OM radiation. Moreover, only the synergy of 280 nm and 365 nm allows to significantly reduce the level of the number of mesophilic bacteria. The synergy of OM radiation with wavelengths of 280 nm and 365 nm reduces the content of pathogens in proportion to the irradiation time, and also oxidizes up to 37 95 creatinine and phenol of organic pollutants.

The inhibitory effect of low-intensity 405 nm radiation on pathogen reactivation processes has been established. UV light can repair damaged DNA through a process known as photoreactivation. Essentially, light in the 300-500 nm range activates photolyase to repair DNA by forming cyclobutane pyrimidine dimers (CPOs), the most common types of photodamage. To remove light-induced damage in

Many organisms use enzymes specifically bound to SPO (SPO photolyase) or 6-4PP (6-4PP photolyase) to repair DNA damage. SPO photolyases are found in bacteria and fungi. White light or OMV radiation induces the expression of SPO photolyases. Additional chromophores have absorption maxima at wavelengths of 380 nm and 440 nm |50ОЙ Considering this, OMA LEDs should not be used at this wavelength of emission.

The task is solved in such a way that the device for LED ultraviolet bactericidal disinfection of air and contagious surfaces contains a housing (1), a contact group of electrical power (2), an LED source of monochrome

From ultraviolet radiation (3), placed on the front surface of the case (1), which contains LEDs of the short-wave range MS with a wavelength of 220-230 nm (4), short-wave range LEDs with a wavelength of 275-285 nm (5), LEDs of the long-wave range of the CMA with a wavelength waves of 360-370 nm (6) and long-wave OMA LEDs with a wavelength of 400-410 nm (7).

The LEDs of the short-wavelength range of the ShMS emit directed illumination in the bactericidal range with an intensity that corresponds to the maximum permissible dose at eye level.

LEDs of the long-wavelength range of SMA emit wavelengths of the middle and end of the range, with directional illumination of the surface of possible contaminated objects, which is a source of fomite infection. From the point of view of photobiological safety of those present in the irradiation zone, a necessary condition is to limit the total power of OM radiation to the level of the minimum erythema dose in the area of the eyes and exposed parts of the human body.

Thus, the combination of LEDs of different ranges allows you to implement all currently proven models of destruction of pathogens that spread with the help of aerosols and fomites. SHMSO radiation damages and breaks amino acids in the DNA and RNA chain;

OMA (360-370 nm) causes damage to pathogens using singlet oxygen; OMA (400-410 nm) leads to volumetric destruction of pathogen cells and prevents photoreactivation by blocking recombinations.

Also according to the proposal, the proposed device may contain a microcontroller (8) for controlling the device and a proximity sensor (9) that reacts in the event of an approach of less than 1 m to the device and with the help of the microcontroller (8) automatically turns off all the LEDs of the short-wave range of MS length waves of 275-285 nm (5) and all LEDs of the long-wave range of SMA with a wavelength of 400-410 (7). At the same time, in order to continue the bactericidal effect of the device, the LEDs of the short-wave range of SHMS with a wavelength of 220-230 nm (4) and the LEDs of the long-wave range of OSHMA with a wavelength of 360-370 nm (6) continue to work.

In addition, according to the proposal, the device may contain a microcontroller (8) and a presence sensor (10), which reacts to movement in the room and with the help of the microcontroller (8) automatically turns on all the LEDs of the short-wave range of the SHMS with a wavelength of 220-230 nm (4) and all LEDs of the short-wave range OMS with a wavelength of 275-285 nm (5) and turns them off in the absence of people, which significantly increases the life of the LEDs of the short-wave range. At the same time, to maintain an acceptable bactericidal state of the room, LEDs of the long-wave range of OMA with a wavelength of 360-370 nm (b) and LEDs of the long-wave range of OMA with a wavelength of 400-410 nm (7) are constantly on.

Also according to the proposal, the proposed device is a microcontroller (8) and an air humidity sensor (11), which turns off all LEDs of the short-wave range of SHMS with a wavelength of 220-230 nm (4) and all LEDs of the short-wave range of SHUMS with a wavelength of 275-285 nm (5) in the case of an increase in air humidity of more than 85 95 with the help of a microcontroller (8). At the same time, in order to maintain an acceptable bactericidal state of the room, LEDs of the long-wave range of SMA with a wavelength of 360-370 nm (6) and LEDs of the long-wave range of OMA with a wavelength of 400-410 nm (7) are constantly on.

In addition, according to the proposal, the proposed device may include a microcontroller (8),

OMS sensor (12) and OMA sensor (13), which are used to calculate the transparency of the environment, and in case of reaching a critical concentration of dust in the air of the room, the microcontroller (8) automatically turns off all LEDs of the short-wave range of OMS with a wavelength of 220-230 nm (4), and all LEDs of the short-wave range of 275-285 nm (5).

At the same time, in order to maintain an acceptable bactericidal state of the room, LEDs of the long-wave range of SMA with a wavelength of 360-370 nm (6) and LEDs of the long-wave range of OMA with a wavelength of 400-410 nm (7) are constantly on.

Also according to the proposal, the proposed device may contain a wireless communication module (14) for remote control of the device. This allows you to create a wireless control network and adjust radiation levels in different ranges depending on the size of the premises, as well as monitor the performance of the device.

In addition, according to the proposal, the contact group of the electric power supply (2) of the device can provide independent power supply of the LEDs of the SHMS and OMA bands on different independent circuits with a delay equal to the sampling frequency from 100 Hz with automatic alternating power switching between circuits using a microcontroller (8 ). This allows you to reduce energy consumption and improve the removal of heat energy from LEDs during operation, which generally increases the life of the device. When turning on the power supply line of the OMC LEDs, the power supply line of the OMA LEDs is turned off, and vice versa.

Brief description of the drawings

The possibility of implementing a useful model characterized by the above set of features, as well as the possibility of realizing its purpose, is confirmed by the description and illustrated by graphic materials.

Fig. 1 - scheme of the device of the LED ultraviolet bactericidal disinfection of air and contagious surfaces.

Fig. 2 - scheme of destruction of the OM genome by radiation.

Fig. C is the spectral energy composition of the radiation.

Fig. 4 - spectral sensitivity of pathogens.

Fig. 5 - spectral dependence of biological effects of OM radiation.

Fig. b - curves of the relative spectral bactericidal and mutagenic efficiency of OM radiation.

Fig. 7 - virucidal efficiency of 280 nm SMF.

The best option for implementing a useful model

In the best embodiment, the device for LED ultraviolet bactericidal lighting of the air space and surfaces of the room (see Fig. 1) contains a housing (1), a contact group of electric power (2) and an LED source of monochrome ultraviolet radiation (3), placed on the front surface of the housing ( 1), containing LEDs of the short-wavelength range of SHMS with a wavelength of 220-230 nm (4) - provide the inactivating effect of the device and 275-285 nm (5) - provide the immunomodulating effect of the device, as well as LEDs of the range of SHMA with a wavelength of 360-370 nm (b ) - ensure the occurrence of free radical cytotoxicity, and 400-410 nm (7) - ensure the inhibitory reactivation of pathogens.

Proximity sensor (9), presence sensor (10), air humidity sensor (11), SHMS sensor (12) and OMA sensor (13), as well as a wireless communication module (14) allow using a microcontroller (8) to ensure the operation of the device so that if there are no people in the room, the device automatically leaves only the LEDs of the long-wave range OMA with a wavelength of 360-370 nm (6) and a wavelength of 400-410 nm (7), and the LEDs of the short-wave range of the SHMS with a wavelength of 220-230 nm (4) and those with a wavelength of 275-285 nm (5) are automatically turned off. When people appear, the presence sensor (10) is triggered, after which the LEDs of the short-wave OMS range with a wavelength of 220-230 nm (4) and a wavelength of 275-285 nm (5) are turned on. When a person approaches the device at a distance of less than 1 m, the proximity sensor (9) is activated and the LEDs of the short-wave range SHMS with a wavelength of 275-285 nm (5) and LEDs of the long-wave range of the UMA with a wavelength of 400-410 nm (7) are turned off, and disinfection the room continues to be powered by LEDs of the short-wave range SHMS with a wavelength of 220-230 nm (4) and LEDs of the long-wave range of the SHMA with a wavelength of 360-370 nm (6), which emit in a range that is not harmful to human skin and eyes. In the event of an increase in humidity above 85 95, the air humidity sensor (11) turns off the LEDs of the short-wave range

OMS with a wavelength of 220-230 nm (4) and a wavelength of 275-285 nm (5). Air treatment continues exclusively with LEDs of the long-wavelength range of the SMA with a wavelength of 360-370 nm (6) and a wavelength of 400-410 nm (7).

The wireless communication module (14) allows you to remotely adjust the intensity of the device's operation in the OMA and OMS ranges according to the sensor indicators, as well as monitor the intensity of the OMA LEDs in order to check their working condition.

The electrical power contact group (2) provides independent power supply for the LEDs

OMS and OMA ranges on different independent circuits with a delay equal to the sampling frequency from 100 Hz with automatic alternating power switching between circuits using a microcontroller (8), reducing power consumption and improving heat dissipation from LEDs during device operation.

Industrial suitability

The stated technical solution fulfills the task. The advantages of the claimed device are mentioned above with reference to the implementation of the utility model, but in general the features of the claimed utility model are disclosed in the description, formula and figures in certain combinations with each other. At the same time, a specialist in this field of technology, when implementing a useful model, will be able to use these features individually or in combination in other rational combinations.

Table 7

Study of values of blue light exposures dangerous for the retina of the eye. and Blue light, Visible Function Limit

Distance from and danger value y (380-500 nm), spectrum of light, Ktah, NM and lamp, m mW/sme (400-700 nm), lux of blue exposure, light, V(X) W/me 408 0, 4 1.00 2101 171110053. 177711 HER

Note: " - below the sensitivity of the measuring device

According to the research results shown in Table 7, the maximum wavelength

Zo (Atah) of blue light when the device is working is 408 nm with the blue light hazard function

B(X) - 0.4. At the same time, the blue light exposure value exceeds the limit level only at a distance of 0.05 m from the switched-on device. At a distance of more than 0.2 m, the parameters of blue light meet the requirements of DSTU EM 62471:2017 "Safety of lamps and lamp systems photobiological". Therefore, the recommended dose of OMS and OMA radiation can effectively inactivate the airborne virus.

Below are the results of experimental studies of the efficiency of the device (see Table 8 and Table 9).

Table 8

Doses of OM for different pathogens with bactericidal efficiency of 90 95 and 99.9 95 and exposure value of OM at different distances from the device green streptococcus

Ege sini NIE TNN NOSI VONO NO NNYA NOYA NO VANYA (diphtheria bacillus)

GE" essay NINI NN-LYNY NN NO VONO NI NOYA NO NOYA (golden staphylococcus) write 1272 11111 (tuberculosis bacillus) lush 1 1111711 for monochrome OM, J/m2 x- according to R 3.6.1004-04 "Use of ultraviolet bactericidal radiation for indoor air disinfection"

Table 9

Time required for deactivation of 90 95 and 99.9 95 pathogens when the device is turned on

Bactericidal Amount of time to reach 90 95/99.9 9o

Pathogen Effectiveness of the bactericidal effect (minutes) zigeriosossivz migidiap5

Sogupebasiegiit dirpiyegtia Z8 73 0.26/0.5 4.1/7.9 31.7/61 158/304 (diphtheria bacillus) "arnuiosossiv aigoiv"

Musobasietiit

Tiregsiov5iv (tuberculous 61 113 0.41/0.77 6b,6/12.3 50.8/94.2 254471 bacillus)

During the operation of the device, the main energy of CM radiation is represented in the range

MS (200-280 nm). The minimum distance at which the exposure of OM for 8 hours per day does not exceed the established limit value of exposure of OM radiation in effective value (30 J/m2) is a distance of 1.5-2 m from the switched-on lamp. At the same time, the safe distances from the switched-on device for the ranges of ШМВ and ОМА are distances of 0.15-0.5 m (the intensity of ШМ radiation is less than the sensitivity of measuring devices). At a distance of 1.0 m from the switched-on device, the permissible stay time, taking into account the risks of dangerous effects on human skin and eyes, should not exceed 60 minutes. Therefore, the dose of OMS and OMA radiation recommended by DSTU EM 62471:2017 can effectively inactivate the airborne virus.

The declared technical solution has been verified in practice. The proposed device does not contain any structural elements or materials that could not be reproduced at the current stage of development of science and technology, at the same time it is distinguished by its simplicity of design and high manufacturability and can be implemented industrially in the conditions of serial production, therefore it meets the requirements of the criterion " industrial suitability".

At the same time, in the known sources of patent and other scientific and technical information, no designs and devices with the set of essential features specified in the proposal, which satisfy the requirements of the "novelty" criterion, were found. Thus, the proposed technical solution is considered to be eligible for legal protection.

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ZAN5-Som-2 heriisayop. 55 AM. 19. Neiyipaion, S5, Ayidegogvi, OMU, Zspirreg, H., Ointe", 0., MUya2Ke, O., Mapa, 0., 7pepo, H., zZytseg, K., TiiPpa, M., AI, M. ей ай!. (2020). ByvzseriibPyu oi BANZ-Som-2 about OM Itadiaynop. Ategisap

Washtai oi Ipesiiop Sopigoi. 20. 5oo-)i Kit, bo-Kushp Kit, bopd-Nushp Kapu Ovipda OMS GidpeEEetinipu Oiodez ai U/ameIepdinz oi 266 yu 279Mapoteiieg5 To Ipasiimaie ERoodbogppe RaSshodepbe apa Ravzivshile 5biisey SNeeze.-

Arriiei apa Epmigopitepia! Misgobioiodu, Chapiagu 2016 Moishte 82 Mitreg 1, yr. 11-17 21. NiyukKo Ipadaki, AKayiziki Zayo, Nigopory Zidiuata, TatakKi OKabauavni a Zpoptssni Etsiitoyo (2020) Varii ipasiimayop oi 5BAN5-SoM-2 m/ypy deer-OM GEO itmadiayop, EEtegdipud Mistore5 4 bo Iptesiiopv5, 9: 1, 1744-1747, BOI: 10.1080 / 22221751.2020.1796529

22. Mogat Segsptap, Nada5 Matape, Mepetua Egiedtap, Misna! MapaveyIroit. OM-GEO diviptesiyup oi Sogopamigiv: UMameIepdiy ePesi./ milddaii oi Rpoiospetivigu a Rpoiobioiodu, In: Viiodu 212 (2020) 112044 / perz //doi.oga/10.1016/).|rpoiobio!.2020.112044 23. And dcyde to OM-S I EOR - razei diviptestop/pEr://mlum.pisnpia-sot 24. map Spepd, Napum Spep, I tsi5 AIrepo Zapspe Vazipo, Miaditig M. Rgoiazepko, Zpuat

Vpagadmzha), Mopidids! Iviat 5 Sagtep I. Mogagy!1. Ipasiimayop oi I ivietia apa E. soii Bu Oeer-OM

And EO: eiMesi oi vyrvigage sopaiiop5 op ipasiimaiiop Kipeiis5. zsiepiyis Kerogiz (2020) 10: 3411 yr.1-14. pbrz //doi.ogu/10.1038/541598-020-60459-8 25. A.-b. Spemgetopi, Appe Maiie Ragpei da 5ima, V. Sociotr, .-I. Wopdeppe ENesi oi soimrieyd

IM-A apa OM-S GEO" op roii testobrioiodisa! apa spetisai roiishiop oi igbap ulavie ulaieg5. osiepse oi She Toiai! Epmigoptepi, EIBemiei, 2012, 426, pp. 304-310.10.1016 / | 5spoiepm.2012.03.043.. Na!- 02069416 26. Zsoi N. I imipdziop MO, Ueppiteg I. Sadpyt V5, Kemip U. Weppeg V5, Sipiv U. Oop5Keu MO.

ENisasu oi ap iPgamioiei-A Iopipo zuziet og sopiipysi5 desopiatipaynop oi peaky sage-azzosiaiea rashodepbe op zipasev5.- Vii Verop.- Ategisap Chdotstai! oi Ipythesiop Sopygoi 48 (2020) 337-339

Nerz. AS vishaev5z She ve oi OM-A GEO Ioiiiipu to daiviptesi pozriga! Goth (OROATEB).- Eer 2151, 2020.- pyrz/Lymly vedztadagipe.sot/Lidniipd-peayn-mzheiPreipd/apisiye/14168377/ Igo-51Shadiez-She-y5e-oi-ima-Iea-Idniipd-yu-aiviptesi-pozriitaI --goot 29. Matsgu MUhidni Besopa appiai! Zarrpige Amagi m/ippeg5 ehetriyu aimapsev ip 551.

Iespoiodu.- Mag Zga, 2016-pyrz:/Lmmum Ieaztadagipe.sot/agspiesishiga!-IPdpiipa/gneiai!-poz5ritainu/ apisivie/16696106/5esopa-appia!I-zarrpige-amzhaga-mippegv-ehetriyu-admapsev-ip-55I- tesppoiodu-min- mideo-tadagipe 30. 05 Raiepi F 10,894,104 Nushyp-Ueopu Kit (Zeoitsy), Zapa-No shdypd (Ipspeop). GEO Idniipa demise Tog 5iepiigipud zipase og 5rase. AYETI 2/10 (20060101); AETI. 9/20 (20060101) dap 19,2021 31. Kmat E, Weppeg K. MespNapiviis ipvidnie ipo OM-A teaiaivy Basiegia! aiviptesyop mia epdodepoiv rpoiozep5iiy2geg5. good luck! ой РиПоиоспетизмшму апа Риоиобиоюду In: Vioiodu. 2020:;209:111899. doi:10.1016/|.|rpoiobi-oi.2020.111899 32. Vameep VRainpazipupe, bopia dapaga, Giza Miogip, Misnaye! Zspoivazei, Siiiota Manpke,

Adoyo Sagsia-Zavige. Sing She dni op migiv: migisida! epesiv oi 405 pt miviyie dn op BANZ-Som-2 apa ipiShepga A migiv. rioVhim rgergipi Magsn 15, 2021; doi: por //дои.огд/10.1101/2021.03.14.435337 33. Zsoi N. I imipdziop MO, Ueppiteg I. Sadpyt V5, Kemip U. Weppeg V5, Sypiv U. Oop5Keu MO.

ENisasu oi ap shPygamioie(-A Idniipa 5uzivt og sopiipysi5 desopiatipaiop oi Neanyi sage-a5zzosiaied raishodepb5 op ziyase5. 0196-6553 / Rybriiznei ru

Eizemiveg Ips. op Beyaii oi Avzosiaiop og Rgoiezviopa!5 ip Iptesiop Sopit! apa Eridetioiodu, Ips.

Nerz. dog 5piguakK, Soppog StisKktoge, Aiap MU.

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That's sopigo! She 5rgeai oi aiibogpe-tediaied tisgtobiaiI dieeabze5. - bBioNkhKhim rgergipi to: porz//дой.огд/10.1101/240408 36. SIE (2010) SIE 1872010 OM-b rnoosagsipodepeviv gizK5 yot deptisidai

Iatr5./pyr//siv.so.a/pem/5/siv-geIeazev5-imo-Keu-ribiisayopv-im-aiviptesip 37. Sage222F Rinegei Bag OM-S Ekhsiteg Gatr Modiie-pNrv:/Lymly. i5pio.sot/rgodisusage222- tiKeged-tag-im-s-eksiteg-Iatr-tody!e/ 38. Rai-OMO Gidni Mapiitasiygeg5.-pErz /Lumlu. takes sot/207-222-pt-ims-IIdpi-sap-5iom-5rgeadoi-pomeI-sogopamigy5-somia-19/ 39. pIrv/Lymly.popapoiesp.sot/rovi/pz-papoiesp-5pomsavzev-Tag-imo- 5pogmameiidp-ai-sev5 40. Kemip Kapp. MU/song OMO Boyigse from Vevi? 222 pt m5. 265 pt og Oiviptesiyop oi Aig, Bypase, apa MUaieg. Kiagap Shopimeg5yu. RErv/Lymly.Kiagap.sot/revi-imo-50ygse-222-pt-m5-265-pt-maieg- zipase-aig-aibviptesiop 41. Nobrep Guess. Oiviptesiapiv socia re Neiripu Bbasietia o resote geviviapi. pErz /Llyumly.pemv-teaisa!.pe/pemuv/ 20210222/Oi5ip'estapiv-sosha-re-peiIripa-basiegia-o-resote-teviviapi.azrh 42. pprv/Lyumly Lopuypdu.sot/adizriaurgodisi.piti?rgo!0 -2711014 43. 0О5Х108 (Nem 12/15/20) 3650ibvipEeh -AMO-OMA-Thesppoiodu. Epomea A-1029013. mlum.desitepisot 60 44. pirv //rgodisiv.desitepi.sot/ipaoog-IaNiipa/ aibvip'esiop

45. Raiepi Mo.: О5 9, 937, 274 B2 PONT rIBIMEESTIOM 5MZTEM AMO METNOYU 46. OZ Raiepi 2О5945710982 METNOYU AMO OEMISE ROV rIBIMEESTIOM AMO/B

ROIOVIRISATIOM OE A REOBIST. Miaditig MaziepCo; AETI. 2/08 (20060101); AETI. 9/18 (20060101);

Ag 7/015 (20060101); СО2Е 1/30 (20060101); А2ЗИ 3/26 (20060101); A23B 4/015 (20060101);

Axes 4, 2016 47. SM Raiepi ZhSM111569103 ROKTAVIE YUOAIG-MAMEVAMO OM TEO ZTEVI2ATIOM

RIBIMEESTIOM GRAM. NS (M/ONAM) TESNMOG OSsmM SO. 1 TO. AbTI 2/10; AYETI 2/26; B21M 29/74; B21M 29/87 48. Mayiv AS, Rak HU), Topogisi MA, UlaiI A., MeScige AT, Meevzieg OO. Bigisishge, Eipsiip, apa

Apiidepisyu oi She 5BAN5-Sou-2 brike Siusorgoivip. That's it. 2020 Mag 6. aoi: 10.1016 / |. sei!I.2020.02.058 49. pyr5 /py.vygopem5.sot/2021/04/21/ ipaiiap-doibiv-tshapi 50. pyr/Lymly.seiPrio!py/rooKk/toIeKiiuataua bBiioodiua/geragasiua apk/ iogeakKiiimasiua 51. Spyp -Spien Twepud apa Spip-5nap Gi. Ipasiimayop oi Migize5 op Zipasez Bu ShPgamioiei

Septicide! Ingadianop.- Uoitai oi Ossyraiiiiopai! apa Epmigoptepia! Nudiepe, 4: 400-405 ro!: 10.1080/15459620701329012 52. U.A. Vgop5, A. Vivttap, Y. Mupiye, K. Veppeg, GG. Oepd. Ap abzezztepi oi a pubtia Idnipd vubvivt Shai etrioubz Shiigamioiei-A yTog tidaiypd Neainsage-azzosiaiei ipiesiop5 ip a pembot iptepvime sage shipii. Hydniip Ne5. Thespians 2020; 52: 704-721 53. ISMIVR SSHIOBYESIME5. About

MAMEGEMYITN VETMEEM 180 Mt AMO 400 Mt (IMSONEVEMT ORTISAI VABPIATIOM)

ROVI IZNEO IM: NEASTN RNUBIS5 87(2):171-186; 2004

Claims (7)

USEFUL MODEL FORMULA 1. Device for LED ultraviolet bactericidal lighting of the air space and surfaces of the room, containing a housing (1), a contact group of electric power (2), at least one LED source of monochrome ultraviolet radiation (3), placed on the front surface of the housing (1), which differs by the fact that the LED source ZO of monochrome ultraviolet radiation (3) contains at least one LED of the short-wave range SHMS with a wavelength of 220-230 nm (4), at least one LED of the short-wave range of SHUMS with a wavelength of 275-285 nm (5), at least one LED of the long-wave range OMA with a wavelength of 360-370 nm (b) and at least one long-wavelength UMA LED with a wavelength of 400-410 nm (7). 2. The device according to claim 1, which is characterized by the fact that it contains a microcontroller (8) for controlling the device and a proximity sensor (9), which reacts in the event of an approach of less than 1 m to the device and with the help of the microcontroller (8) automatically turns off all the LEDs of the short-wave range MS with a wavelength of 275-285 nm (5) and all LEDs of the long-wave range of SMA with a wavelength of 400-410 nm (7). 3. The device according to claims 1-2, which is characterized by the fact that it additionally contains a presence sensor (10), which reacts to movement in the room and, with the help of a microcontroller (8), automatically turns on all the LEDs of the short-wave range of SHMS with a wavelength of 220-230 nm (4 ) and all LEDs of the SHMS short-wave range with a wavelength of 275-285 nm (5). 4. The device according to claims 1-3, which is characterized by the fact that it additionally contains an air humidity sensor (11), which turns off all the LEDs of the short-wave range of SHMS with a wavelength of 220-230 nm (4) and all the LEDs of the short-wave range of SHMS with a wavelength of 275-285 nm (5) in case of an increase in air humidity of more than 85 95 with the help of a microcontroller (8). 5. The device according to claims 1-4, which is distinguished by the fact that it additionally contains a SHMS sensor (12) and an OMA sensor (13), which are used to calculate the transparency of the environment, and in the case of reaching a critical concentration of dust in the air of the room, a microcontroller (8) automatically turns off all LEDs of the short-wavelength range of 220-230 nm (4) and all LEDs of the short-wave range of 275-285 nm (5). b. The device according to claims 1-5, which is characterized by the fact that it additionally contains a wireless communication module (14) for remote control of the device. 7. 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