WO2019210852A1 - 取样卫生巾及其应用 - Google Patents

取样卫生巾及其应用 Download PDF

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Publication number
WO2019210852A1
WO2019210852A1 PCT/CN2019/085187 CN2019085187W WO2019210852A1 WO 2019210852 A1 WO2019210852 A1 WO 2019210852A1 CN 2019085187 W CN2019085187 W CN 2019085187W WO 2019210852 A1 WO2019210852 A1 WO 2019210852A1
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sanitary napkin
layer
sanitary
biofilm
cancer
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PCT/CN2019/085187
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English (en)
French (fr)
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黄婉秋
黄健
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Huang Wanqiu
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150045—Source of blood for blood from vagina, placenta, colon or mouth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150358—Strips for collecting blood, e.g. absorbent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/45—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the shape
    • A61F13/47—Sanitary towels, incontinence pads or napkins
    • A61F13/472—Sanitary towels, incontinence pads or napkins specially adapted for female use

Definitions

  • the invention relates to the technical field of sanitary articles, in particular to a cell/nucleic acid sampling sanitary napkin with medical sampling function and application thereof.
  • Menstruation is a sign of female genital maternal function as a result of changes in ovarian hormones, periodic endometrial shedding, and endometrial vascular bleeding.
  • Menstrual blood in addition to blood, menstrual blood, as well as endometrial debris, cervical mucus and vaginal epithelial cells.
  • Menstrual blood also contains prostaglandins and a large amount of plasmin from the endometrium. Due to the lysis of fibrin by plasmin, menstrual blood does not condense, and blood clots only occur when bleeding occurs.
  • Menstrual blood is a special test specimen for women.
  • the use of menstrual blood for gene mutation analysis and metagenomic analysis is of great significance for the diagnosis and treatment monitoring of diseases.
  • the sanitary napkin generally comprises a top layer, a base film and an absorbent core between the top layer and the base film.
  • the top layer is a part that directly contacts the skin, and the material needs to be soft, and the weave and the indentation on the surface of the surface layer are not absorbed by the menstrual blood.
  • the absorbent core is mainly an absorbent core made of cotton, non-woven fabric, pulp or a composite of these materials for absorbing menstrual blood.
  • the base film of the sanitary napkin is a water-impermeable material that retains the menstrual blood in the absorbent core while keeping the undergarment clean.
  • the sanitary swab is generally composed of a cylindrical absorbent cotton core and a pull wire at the end of the cotton core.
  • sanitary napkins or sanitary swabs currently on the market are designed to improve the comfort of women during menstruation. They are used in a single way. They are usually discarded as household waste after use. There is no medical sampling function for cell/nucleic acid sampling sanitary napkins/sanitary swabs. appear.
  • the technical problem to be solved by the present invention is to provide a sample sanitary napkin capable of extracting cells, nucleic acids, and disease-related pathogens such as bacteria, viruses, molds and the like from menstrual blood, which is very suitable for clinical detection of vaginal micro-ecology. It is also suitable for gene mutation analysis of cells or nucleic acids for early screening or diagnosis of diseases such as cervical cancer.
  • a sanitary napkin comprising a topsheet, a base film and an absorbent core positioned between the topsheet and the base film, the biofilm layer being disposed between the facing layer and the absorbent core .
  • the biofilm layer is a filter that allows free filtration of water and leaves cells and other formed components.
  • the biofilm layer is made of a polymer material, including fibers, fiber cotton, rayon, nylon membrane, or a filter membrane made of a biodegradable material.
  • the biofilm can be set to have different pore sizes according to requirements, usually 10-15 ⁇ m, for adsorbing different sizes of substances such as bacteria, cells or nucleic acids.
  • the material of the surface layer includes cotton or polyethylene film, and the polyethylene film (PE) is provided with a microporous design, which can make the menstrual blood not easy to rewet, so that the user has a dry feeling, but the PE film material is hard and partially used. May cause an allergic reaction.
  • PE polyethylene film
  • the surface of the top layer is provided with an opening and a point break line for the medical examiner to conveniently tear the surface layer and take out a biofilm having a surface such as bacteria, cells or nucleic acids.
  • a sanitary tampon comprising a cylindrical absorbent cotton core and a pull wire disposed at an end of the absorbent cotton core, the outer surface of the absorbent cotton core being provided with a cotton top layer, the surface A biofilm layer is also disposed between the layer and the absorbent cotton core.
  • the use of the above sanitary napkin/siton swab for preparing a product for detecting or screening for a disease-related pathogen including bacteria, viruses, molds, trichomoniasis, mycoplasma Or chlamydia the pathogen is mainly used for vaginal microecological testing, and can also be used for detection of hepatitis C virus.
  • a disease-related pathogen including bacteria, viruses, molds, trichomoniasis, mycoplasma Or chlamydia
  • the pathogen is mainly used for vaginal microecological testing, and can also be used for detection of hepatitis C virus.
  • sanitary napkin/siton swab for the preparation of a product for detecting and screening for disease-related genes.
  • the invention samples a biofilm in a sanitary napkin or a sanitary swab, and can filter the retained cells and nucleic acids, and the cells and nucleic acids can be used for gene mutation detection and analysis.
  • sanitary napkin/siton swab for the preparation of a product for early screening or diagnosis of gynecological diseases. Because of the blood in the menstrual blood, as well as endometrial debris, cervical mucus and vaginal epithelial cells, the cells and nucleic acids collected by sampling sanitary napkins or sanitary swabs of the present invention are used for gene mutation detection and analysis. Screening or diagnosis of diseases such as the cervix, especially cervical cancer, endometrial cancer and ovarian cancer.
  • the uterine blood stem cells are the most self-replicating and directed differentiation stem cells. They are derived from the endometrium and are excreted by menstrual blood. Their differentiation potential is similar to that of embryonic stem cells, and they have low immunogenicity. Allogeneic transplantation has no immune rejection or The weak response characteristics can be used to treat a variety of diseases.
  • the sampled sanitary napkin or the sanitary cotton swab of the invention can be used to collect the uterine blood stem cells, which is simple and convenient, and does not need to be matched, and can be used by people without blood relationship.
  • the sample sanitary napkin of the invention can extract cells, nucleic acids, and disease-related pathogens such as bacteria, viruses, molds and the like from menstrual blood, is very suitable for the detection of clinical vaginal micro-ecology, and is suitable for gene mutation analysis of cells or nucleic acids. For early screening or diagnosis of diseases such as cervical cancer.
  • the sample sanitary napkin of the invention can also be used for extracting uterine blood stem cells, and the uterine blood stem cells can treat various diseases after being cultured and expanded in vitro, and have broad application prospects.
  • Figure 1 is a front elevational view of the sample sanitary napkin of the present invention
  • Figure 2 is a schematic cross-sectional view of the sample sanitary napkin of the present invention.
  • Figure 3 is a schematic illustration of a sample taken from a sample sanitary napkin of the present invention.
  • 1 is the top layer
  • 2 is the base film
  • 3 is the absorbent core
  • 4 is the biofilm layer
  • 5 is the opening
  • 6 is the point broken line
  • 7 is the side wing.
  • the present invention samples a sanitary napkin comprising a topsheet 1, a base film 2, and an absorbent core 3 between the topsheet 1 and the base film 2, the facing layer 1 and the absorbent core.
  • a biofilm layer 4 between 3.
  • the material of the biofilm layer 4 is preferably a polymer nano biofilm, and the biofilm can be provided with pore sizes of different sizes according to requirements for adsorbing substances of different sizes such as bacteria, cells or nucleic acids.
  • the surface of the sanitary napkin top layer 1 is provided with an opening 5 and a point break line 6 for the medical examiner to conveniently tear the surface layer 1 and remove the surface with bacteria, cells or nucleic acids.
  • the biofilm is placed in a preservation tube for associated pathogen detection. It can be used for vaginal micro-ecological testing, such as detection of mold, trichomoniasis, mycoplasma, or chlamydia, as well as detection of bacteria or viruses such as hepatitis C virus.
  • vaginal micro-ecological testing such as detection of mold, trichomoniasis, mycoplasma, or chlamydia
  • detection of bacteria or viruses such as hepatitis C virus.
  • the sample sanitary napkin of the present invention can also be used to extract uterine blood stem cells.
  • the uterine blood stem cells are the most self-replicating and directed differentiation stem cells. They are derived from the endometrium and are excreted by menstrual blood. Their differentiation potential is similar to that of embryonic stem cells, and they have low immunogenicity. Allogeneic transplantation has no immune rejection or The weak response characteristics can be used to treat a variety of diseases.
  • the sampled sanitary napkin of the invention can be used to collect uterine blood stem cells, which is simple and convenient, and can be treated for various diseases after being cultured and expanded in vitro.
  • the sample sanitary napkin of the present invention further comprises a side flap 7 which is an outwardly extending portion of the topsheet 1 and the base film 2 to prevent leakage of the undergarment by leakage of a large amount of menstrual blood.
  • the sample sanitary napkin of the present invention can be tested by a medical examiner after the female has used up.
  • the medical examiner first tears off the break line 6 from the opening 5 on the top layer 1 of the sanitary napkin (see Fig. 3), removes impurities such as mucus on the surface layer 1, and takes out the second layer of the biofilm.
  • a substance such as bacteria, cells, or nucleic acid remains on the membrane, and the biofilm is placed in a preservation tube to perform pathogen detection or genetic analysis.
  • the medical examiner takes out the biofilm in the sample sanitary napkin and puts it into a preservation tube to extract bacteria, viruses, cells or nucleic acid substances in the menstrual blood left on the biofilm.
  • the extracted substance was subjected to PCR detection of hepatitis C virus HCV-RNA, and as a result, a patient who was positive for HCV-RNA, that is, a female patient chronically infected with hepatitis C, was also positive for serum anti-HCV, and liver biopsy was also displayed.
  • the HCV-RNA test was negative and the serum anti-HCV test was also negative.
  • the medical examiner takes out the biofilm in the sample sanitary napkin and puts it into a preservation tube to extract the cells or nucleic acid substances in the menstrual blood left on the biofilm.
  • the extracted nucleic acid substance is detected by PCR and polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RLFP) to detect the presence or absence of a gene related to human cervical cancer related genes such as epidermal growth factor receptor gene (EGFR). Mutations provide a clinical basis for early screening or diagnosis of cervical cancer.
  • PCR-RLFP polymerase chain reaction-restriction fragment length polymorphism analysis

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Abstract

一种取样卫生巾，包括面层（1）、底膜（2）和位于面层（1）与底膜（2）之间的吸收芯体（3），面层（1）和吸收芯体（3）之间还设有生物膜层（4）。取样卫生巾能从月经血中提取细胞、核酸等，适用于女性疾病相关基因变异分析；还可收集细菌、病毒、霉菌等疾病相关病原体，用于临床上阴道宫颈微生态分析；还适用于宫颈癌等疾病的早期筛查或诊断，具有广阔的应用前景。

Description

取样卫生巾及其应用 技术领域
本发明涉及卫生用品技术领域，尤其涉及一种具有医学取样功能的细胞/核酸取样卫生巾及其应用。
背景技术
月经是女性随着卵巢激素的变化，子宫内膜周期性脱落和子宫内膜层血管的出血，是女性生殖功能成熟的标志。月经血除血液外，还有子宫内膜碎片、宫颈黏液及脱落的阴道上皮细胞。月经血中还含有前列腺素及来自子宫内膜的大量纤溶酶。由于纤溶酶对纤维蛋白的溶解作用，月经血不凝，只有在出血多时出现血凝块。
月经血是女性一个特殊的检测标本，利用月经血进行基因变异分析和宏基因组分析,对疾病的诊断和治疗监测具有重要意义。但是，目前临床上还没有采集月经血的理想器具，不利于临床月经血的检测和推广应用。
卫生巾/卫生棉棒是女性月经期间使用的物品。其中，卫生巾一般包括面层、底膜和位于面层与底膜之间的吸收芯体。面层是直接与肌肤接触的部分，其材质需要柔软，面层表面的织法和压痕起到经血吸收不回渗的效果。吸收芯体主要是由棉、不织布、纸浆或这些材质复合物制成的吸收芯，用来吸收经血。卫生巾的底膜是不透水材质，可将经血保留在吸收芯体中,同时保持内裤的洁净。卫生棉棒一般是由圆柱形吸水棉芯及棉芯末端的拉线组成。
目前市场上的卫生巾或卫生棉棒多数为提高女性经期舒适感而设计，用途单一，通常使用完后都作为生活垃圾直接丢弃，尚无医学取样功能的细胞/核酸取样卫生巾/卫生棉棒出现。
发明内容
本发明要解决的技术问题是提供一种取样卫生巾，该卫生巾能从月经血中提取细胞、核酸、及细菌、病毒、霉菌等疾病相关病原体，非常适于临床上阴道微生态的检测，并适于细胞或核酸的基因突变分析，用于宫颈癌等疾病的早期筛查或诊断。
为了解决上述技术问题，本发明通过如下技术方案实现:
在本发明的一个方面，提供了一种卫生巾，包括面层、底膜和位于面层与底膜之间的吸收芯体，所述面层和吸收芯体之间还设有生物膜层。
所述生物膜层是一种能让水份自由滤过并留下细胞和其它有形成分的滤膜。
优选的，所述生物膜层的材质为高分子材料，包括纤维、纤维棉、人造丝、尼龙膜、或可生物降解材料制成的滤膜。该生物膜可以根据需求设置不同大小的孔径，通常为10-15μm， 用于吸附不同大小的物质如细菌、细胞或核酸等。
所述面层的材质包括棉质或聚乙烯膜，聚乙烯膜(PE)加有微孔设计，能让经血不易回渗，让使用者有干爽的感觉，但是PE膜材质较硬，部分使用者会引起过敏反应。而棉质面层随着吸收力设计的改善，使更多的女性选择使用棉质面层的卫生巾。
优选的，所述面层的表面设有开口和点断线，用于医学检验人员方便地撕开面层，取出表面留有细菌、细胞或核酸等物质的生物膜。
在本发明的另一方面，还提供了一种卫生棉棒，包括圆柱形吸水棉芯和设于该吸水棉芯末端的拉线，所述吸水棉芯外表面设有棉质面层，该面层与吸水棉芯之间还设有生物膜层。
在本发明的另一方面，还提供了上述卫生巾/卫生棉棒的应用，用于制备检测或筛查疾病相关病原的产品，所述疾病相关病原包括细菌、病毒、霉菌、滴虫、支原体、或衣原体，该病原主要用于阴道微生态检测，也可用于丙型肝炎病毒等检测。使用本发明的取样卫生巾或卫生棉棒，可方便地收集女性患者各种疾病相关病原，这些病原都经过滤留存在取样卫生巾的生物膜上，医学检验人员只需撕开卫生巾面层，即可便捷地取出生物膜，将其放入保存管中，进行相关的病原检测。
在本发明的另一方面，还提供了上述卫生巾/卫生棉棒用于制备检测分析或筛查疾病相关基因的产品的应用。本发明取样卫生巾或卫生棉棒中的生物膜，可过滤留存细胞和核酸，这些细胞和核酸能用于基因突变检测和分析。
在本发明的另一方面，还提供了上述卫生巾/卫生棉棒用于制备早期筛查或诊断妇科疾病的产品的应用。由于月经血中除血液外，还有子宫内膜碎片、宫颈黏液及脱落的阴道上皮细胞等，利用本发明取样卫生巾或卫生棉棒收集的细胞和核酸，进行基因突变检测和分析，可早期筛查或诊断宫颈等疾病，特别是宫颈癌、子宫内膜癌及卵巢癌等。
在本发明的另一方面，还提供了上述卫生巾/卫生棉棒用于提取宫血干细胞的应用。
宫血干细胞是自我复制、定向分化能力最强的干细胞，它源于子宫内膜，通过经血排出体外，它的分化潜能与胚胎干细胞相近，又具备免疫原性低，异体移植无免疫排斥反应或反应较弱的特性，可用于治疗多种疾病。利用本发明的取样卫生巾或卫生棉棒，可收集宫血干细胞，简单方便，且无需配型，可供无血缘关系的人使用。
本发明的取样卫生巾，能从月经血中提取细胞、核酸、及细菌、病毒、霉菌等疾病相关病原体，非常适于临床上阴道微生态的检测，并适于细胞或核酸的基因突变分析，用于宫颈癌等疾病的早期筛查或诊断。此外，本发明的取样卫生巾，还可用于提取宫血干细胞，该宫血干细胞经体外培养扩增后，能治疗多种疾病，具有广阔的应用前景。
附图说明
图1是本发明取样卫生巾的正面主视图；
图2是本发明取样卫生巾的截面示意图；
图3是本发明取样卫生巾采集样品示意图。
图中：
1为面层，2为底膜，3为吸收芯体，4为生物膜层，5为开口，6为点断线，7为侧翼。
具体实施方式
下面结合附图和具体实施方式对本发明作进一步详细的说明。
如图1、2、3所示，本发明取样卫生巾，包括面层1、底膜2和位于面层1与底膜2之间的吸收芯体3，所述面层1和吸收芯体3之间还设有生物膜层4。生物膜层4的材质优选为高分子纳米生物膜，该生物膜可以根据需求设置不同大小的孔径，用于吸附不同大小的物质如细菌、细胞或核酸等。
本发明的一个优选实施方式中，卫生巾面层1的表面设有开口5和点断线6，用于医学检验人员方便地撕开面层1，取出表面留有细菌、细胞或核酸等物质的生物膜，并将其放入保存管中，进行相关的病原检测。可进行阴道微生态检测，如检测霉菌、滴虫、支原体、或衣原体等，也可检测细菌或病毒如丙型肝炎病毒等。利用本发明取样卫生巾收集的细胞和核酸，进行基因突变检测和分析，可早期筛查或诊断妇科恶性疾病，如宫颈癌、或子宫内膜癌等。
本发明的取样卫生巾还可用于提取宫血干细胞。宫血干细胞是自我复制、定向分化能力最强的干细胞，它源于子宫内膜，通过经血排出体外，它的分化潜能与胚胎干细胞相近，又具备免疫原性低，异体移植无免疫排斥反应或反应较弱的特性，可用于治疗多种疾病。利用本发明的取样卫生巾，可收集宫血干细胞，简单方便，经体外培养扩增后，能治疗多种疾病。
本发明的另一个优选实施方式中，本发明取样卫生巾还包含侧翼7，侧翼7是面层1和底膜2向外延伸的部分，可防止经血量多时渗漏弄脏内裤。
本发明的取样卫生巾，在女性用完后，可供医学检验人员进行检测。检验时，医学检验人员先从卫生巾面层1上的开口5处沿点断线6撕开(见图3)，去除面层1上的粘液等杂质，取出第二层生物膜，该生物膜上留有细菌、细胞或核酸等物质，将该生物膜放入保存管中，进行相关病原检测，或进行基因分析。
实施例1
医学检验人员将取样卫生巾中的生物膜取出后，放入保存管中，提取生物膜上留下的经 血中的细菌、病毒、细胞或核酸物质。接着，将提取的物质进行丙肝病毒HCV-RNA的PCR检测，结果检出HCV-RNA阳性的患者，即为慢性感染丙肝的女性患者，其血清抗-HCV检测也为阳性，且肝活检也显示为慢性肝炎感染，而没有患丙肝感染的女性对照，其HCV-RNA检测均为阴性，且血清抗-HCV检测也为阴性。
实施例2
医学检验人员将取样卫生巾中的生物膜取出后，放入保存管中，提取生物膜上留下的经血中的细胞或核酸物质。接着，将提取的核酸物质采用PCR及聚合酶链反应-限制性片段长度多态分析(PCR-RLFP)等方法，检测人宫颈癌相关基因如表皮生长因子受体基因(EGFR)等是否存在基因突变，为早期筛查或诊断宫颈癌提供临床依据。
以上所述的几种实施方式较为具体和详细，但并不能因此而理解为对本发明专利范围的限制。应当指出的是，对于本领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干变形和改进，这些都属于本发明的保护范围。因此，本发明专利的保护范围应以所附权利要求为准。

Claims (10)

  1. 一种卫生巾，包括面层、底膜和位于面层与底膜之间的吸收芯体，其特征在于，所述面层和吸收芯体之间还设有生物膜层。
  2. 根据权利要求1所述的卫生巾，其特征在于，所述生物膜层的材质为高分子材料，包括纤维、纤维棉、人造丝、尼龙膜。
  3. 根据权利要求1所述的卫生巾，其特征在于，所述面层的表面设有开口和点断线，用于撕开面层。
  4. 一种卫生棉棒，包括圆柱形吸水棉芯和设于该吸水棉芯末端的拉线，其特征在于，所述吸水棉芯外表面设有棉质面层，该面层与吸水棉芯之间还设有生物膜层。
  5. 根据权利要求4所述的卫生棉棒，其特征在于，所述生物膜层的材质为高分子材料，包括纤维、纤维棉、人造丝、尼龙膜。
  6. 根据权利要求4所述的卫生棉棒，其特征在于，所述面层的表面设有开口和点断线，用于撕开面层。
  7. 权利要求1所述卫生巾或权利要求4所述卫生棉棒的应用，其特征在于，用于制备检测分析或筛查疾病相关基因的产品。
  8. 权利要求1所述卫生巾或权利要求4所述卫生棉棒的应用，其特征在于，用于制备检测分析阴道宫颈微生态的产品，所述阴道宫颈微生态的相关病原包括细菌、病毒、霉菌、滴虫、支原体、或衣原体。
  9. 权利要求1所述卫生巾或权利要求4所述卫生棉棒的应用，其特征在于，用于制备早期筛查或诊断妇科疾病的产品，所述妇科疾病包括宫颈癌、子宫癌、子宫内膜癌、卵巢癌、输卵管癌、和/或阴道癌。
  10. 权利要求1所述卫生巾或权利要求4所述卫生棉棒的应用，其特征在于，用于提取宫血干细胞。
PCT/CN2019/085187 2018-05-04 2019-04-30 取样卫生巾及其应用 WO2019210852A1 (zh)

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CN105877925A (zh) * 2014-11-05 2016-08-24 郭佳峰 一种卫生用品制备方法
CN105943252A (zh) * 2016-07-13 2016-09-21 广东茵茵股份有限公司 具备经血参数检测功能的吸湿用品
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CN206730048U (zh) * 2016-09-14 2017-12-12 天津市中科健新材料技术有限公司 一种带检测功能的纸尿裤
CN107647972A (zh) * 2017-09-23 2018-02-02 福清市益兴堂卫生制品有限公司 一种具有分析检测尿液功能的纸尿裤

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* Cited by examiner, † Cited by third party
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US20090082745A1 (en) * 2007-04-04 2009-03-26 Nai-Ko Ying Sanitary article for absorbing excretions of human body
CN105877925A (zh) * 2014-11-05 2016-08-24 郭佳峰 一种卫生用品制备方法
CN105943252A (zh) * 2016-07-13 2016-09-21 广东茵茵股份有限公司 具备经血参数检测功能的吸湿用品
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