WO2019157033A1 - Apparatus for and method of treating viral infections - Google Patents
Apparatus for and method of treating viral infections Download PDFInfo
- Publication number
- WO2019157033A1 WO2019157033A1 PCT/US2019/016814 US2019016814W WO2019157033A1 WO 2019157033 A1 WO2019157033 A1 WO 2019157033A1 US 2019016814 W US2019016814 W US 2019016814W WO 2019157033 A1 WO2019157033 A1 WO 2019157033A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- electromagnetic radiation
- range
- emitting
- light
- centred
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 14
- 208000036142 Viral infection Diseases 0.000 title abstract description 4
- 230000009385 viral infection Effects 0.000 title abstract description 4
- 230000005670 electromagnetic radiation Effects 0.000 claims abstract description 29
- 208000015181 infectious disease Diseases 0.000 claims description 11
- 230000005855 radiation Effects 0.000 claims description 10
- 208000024891 symptom Diseases 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 230000005540 biological transmission Effects 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 7
- 241000700605 Viruses Species 0.000 description 4
- 208000001688 Herpes Genitalis Diseases 0.000 description 3
- 201000004946 genital herpes Diseases 0.000 description 3
- 241000282412 Homo Species 0.000 description 2
- 241000700588 Human alphaherpesvirus 1 Species 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000002483 medication Methods 0.000 description 2
- 241001529453 unidentified herpesvirus Species 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- 241000701074 Human alphaherpesvirus 2 Species 0.000 description 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 description 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 description 1
- 241000701041 Human betaherpesvirus 7 Species 0.000 description 1
- 241001502974 Human gammaherpesvirus 8 Species 0.000 description 1
- 241000701027 Human herpesvirus 6 Species 0.000 description 1
- 206010067152 Oral herpes Diseases 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 150000001875 compounds Chemical group 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000001126 phototherapy Methods 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000007420 reactivation Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000126 substance Chemical group 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000001429 visible spectrum Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The invention relates to an apparatus for and method of, treating viral infections. The apparatus comprises at least one means for emitting divergent, narrow bandwidth electromagnetic radiation centred at 1072nm; and at least one means for emitting visible green-cyan light in the range 470-560 nm.
Description
APPARATUS FOR AND METHOD OF TREATING VIRAL. INFECTIONS
This invention relates to en apparatus that emits both electromagnetic radiation centred around 1072nm and visible tight and method of treating viral infections, in particular, but not exclusively, Herpesvfridae infections.
BACKGROUND
There are at least eight herpesvirus types that infect humans: herpes simplex viruses 1 and 2, varicella-zoster virus, E8V (Epsteln-Berr virus), human cytomegalovirus, human herpesvirus 6, human herpesvirus 7. and Kaposi's sarcoma-associated herpesvirus, ail of which are extremely widespread among humans More than 90% of aduKs have been infected with at least one of these, and a latent form of the virus remains in most people.
Herpes simpiex viruses are categorized into two main types, herpes type 1 (HSV-1 . or oral herpes) and herpes type 2 (HSV-2, or genital herpes) Most commonly, herpes type 1 infection causes sores around the mouth and Bps. although HSV-1 can cause genital herpes, most cases of genital herpes infection are caused by herpes type 2. For many people with the herpes virus, which can go through periods of being dorman.t attacks (or outbreaks) can be brought on by the following conditoi ns general illness (from mid illnesses to serious conditions), fatigue, physical or emotional stress, irnrnunosunnression due to AIDS or such medications as chemotherapy or steroids. Irauma to the affected area, including sexual activity and menstruation. Furthermore it Is known that UV 8 light is a potent stimulus for inducing reactivation of latent herpes simpiex virus (HSV) infections. When an individual is first infected with herpes and exhibits active symptoms, the duration of the primary outbreak will be the worst and most painful and can take 3 to 6 weeks to resolve Subsequent recurrent outbreaks wilt be less severe, typically lasting 3 to 14 days and the frequency will become farther and farther apart with each recurring attack.
Electromagnetic radiation is characterized by its wavelength and its intensity. When the wavelength is within the visible spectrum (approximately from 390nm to 700nm) it is known as "visible light". Electromagnetic radiation less than 300nm is ultraviolet and wavelength greater than 1 ,0O0 are in the infrared region
Low level light therapy (LLLT) in the red region (d35-700nm) has been suggested as an alternative to current medications for accelerated rveaSng. reducing symptoms and
A hand held device that could reduce the pain level, provide symptomatic relief, reduce the length of a herpetic infection outbreak and reduce the interval frequency between outbreaks would offer immediate advantage to individuals afflicted with herpetic infections.
BRIEF SUMMARY OF THE DISCLOSURE
According to a first aspect of the invention there is provided a hand-held battery operated electromagnetic radiation therapy device comprising:
(i) a housing for accommodating the battery:
(ii) an interface region comprising a surface for accommodating at least one means for emitting; divergent narrow bandwidth electromagnetic radiation centred at 1072nm: and at least one means for emitting visible green-cyan light in the range 470-580 nm.
wherein the device is capable of producing, at the site bei ng treated, a radiation intensity of at least 50 uμWatts/cm2 and up to 2 watts/cm2
Preterabiy, the electromagnetic radiation and the visible Merit are pulsed so that they are out of phase so that the electromagnetic radiation centred at 1072 nm is only emitted when the visible light is not emitted.
Preferably, the device includes a frequency modulator for phasing the at least one visible iignt emitting source and the at least one means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1072nm so thai I he visibie light from the at least one visible light emitting source is pulsed out of phase with the infrared light.
Preferably, the device has a bandwidth around 120 nm and the half angle divergence of the electromagnetic radiation is in the range 15° to 45 °.
Preferably, the device further includes any one or more of the following features:
(I) means for fixing the intensity of the radiation within a pre- determined range.
(II) an output monitor with a visible display Indicating correct function of the device both for intensity and wavelength:
(iii) means for controlling the duration of the application of the therapy.
Preferably, the at least one means of the means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1072nm is a solid state light emitting device selected from the group comprising soBd state light emitting diodes (LEDs) or gas discharge devices or a laser diode device.
Preferably, the means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1072nm Includes a PN junction arranged to emit radiation with a wavelength centring at. or about. t072nm.
Preferably, the pulsed electromagnetic radiation is applied at a frequency/repetition rate in the range 300-800 Hz and more preferably at 600Hz. Preferably, the at least one means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1072nm is positioned at a substantially central position on the surface of the interface region and a plurality of means for emitting visible green-cyan light in the range 470-560 nm are positioned around the 1072nm emitter. Preferably, the device further includes one or more means for emitting visible light selected from the group comprising red light in the range 700-635 nm, orange light In the range 635- 590nm: yellow fight in the range 590-560nm and blue light in the range 405-470nm.
It win be appreciated that the design of the interface region surface may comprise a number of one means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1072nm in addition to a number of means for emitting visible green/cyan light in addition to a number of means for emitting other visible lights in the blue, yellow and amber range. Preferably, the minimum pulse width for 1072 nm emission is 300 milliseconds.
According to a further aspect of the invention there is provided a method for treating and/or improvlngbody tissues wherein said body tissue has a herpetic Infection, the method comprising:
exposing said tissue to divergent electromagnetic radiation at a wavelength centred at 1072 nm so as to coincide with peak transmissions of a water molecule and visible green/cyan light in the range 470-560 nm: and
selecting a radiation intensi ty for the electromagnetic radiation capable of producing, at the site of the tissue, a radiation intensity of at least 50 μ Watts/cm2 up to 2 Watts/cm2
The method includes exposing herpetic viralty infected tissue to the selected electromagnetic radiation and visible light resulting in alleviation of the herpetic viral infection.
Preferably, the treatment period is between 3 to 10 minutes and may be repeated several times a day until the symptoms of the infection are alleviated
BRIEF DESCRIPTION OF THE DRAWINGS
Embodiments of the invention are further described hereinafter with reference to the accompanying drawings, in which:
Figure 1 is a plan view of one arrangement of the light emitting means on the surface of the interface region.
Figure 2 is a plan view of a different embodiment of Figure 1.
Figure 3 is a plan view of a yet further embodiment of Figure 1.
Figure 4 is a side view of the device of the present invention
DETAILED DESCRIPTION
Figure 1 shows the surface (1 ) of the interface region, tno surface is surrounded by wall (2) which is raised so that the Interface surface is protected and in use is kept away from direct skin contact Arranged on the surface (1) in a subsiantially centrally position is a means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1072nm (3) and arranged around the periphery are a number of blue visible light emitting means (4a) In use. item (3) will be on when items (4a) are off, the sequence of on/off can
go clockwise or anticlockwise and alternated between the 1072nm emitter and one of the peripheral green/cyan light emitters In the embodiment depicted in Figure 2 there are provided two 1072 nm emitters (3) although the number can be more end is not intended to limit the scope of the application . Surrounding items (3) there ere provided visible green/cyan emitters (4 a) and other visible light emitters (4b). The (4b) emitters can be red. orange, yellow or blue and could in some embodiments can be a combination of one, two, three or four different colours or they may be duplicated colours wnlch pulse synchronously or individually in sequence and out of phase with the 10 72nm emitter. Figure 3 shows a yet further embodiment where a series of visible light emitters are green/cyan (4a) plus any other visible light (4t>. 4c).
With reference to Figure 4 there is shown the hand held device (A ) of the present invention. The device comprises a body (5) which accommodates a battery and a panel (6) which has a means for turning the device on and off and win oh may also comprise a display for assessing duration intensity and other parameters of the treatment.
A typical regimen for light exposure, when using. 1072nm and green/cyan light is for four minutess total of at least 300 ms of 1072nm alternatively with at ieast 300 ms of green/cyan light
A typical regimen cycle for multiple light exposure treatment time of around 4 minutes is:
I. 1072nm (300 ms)
II. Green/Cyan light (300ms)
III.10 72nm (300 ms)
IV. Blue light (300ms)
V, 1072nm (300 ms)
VI. Amber light (300ms)
Optionally red light may be included in the therapy
Throughout the description and claims of this specification, the words "comprise " and "contain" and variat ions of them mean "including but not limited to", and they are not intended to (and do not) exclude other moieties, additives, components, integers or steps. Throughout the description and claims of this specification, the singular encompasses the
plural unless the context otherwise requires. In particular, where the indefinite article is used, the specification is to be understood as contemplating plurality as well as singularity, unless the context requires otherwise Features, integers, characteristics, compounds, chemical moieties or groups described in conjunction with a particular aspect, embodiment or example of the invention are to be understood to be applicable to any other aspect, embodiment or example described herein unless incompatibletherewftn. All of the features disclosed in this specification (including any accompanying claims, abstract and drawings) and/or ail of the steps of any method or process so disclosed, may be combined in any combination except combinations where at least some of such features and tor steps are mutually exclusive. The invention is not restricted to the details of any loregoing embodimemts The invention extends to any novei one. or any novel combination, of the features disclosed in this specification (including any accompanying claims, abstract and drawings), or to any novel one. or any novel combination of the steps of any method or process so disclosed
The reader's attention is directed to ail papers and documents which are filed concurrently with or previous to this specification in connection with this application and which are open to public inspection with this specification, and the contents of all such papers and documents are incorporated herein by reference.
Claims
1 A hand-held battery operated electromagnetic radiation therapy device comprising:
(i) a housing for accommodating the battery:
(ii) an in'erface region comprising a surface tor accommodating at least one means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1072nm: and at least one means for emitting visible green/cyan tight in the range 470-560 nm,
wherein the device is capable of produ cing. at the site being treated, a radiation intensity of at least 50 μWatts/cm2 and up to 2 Watts/cm2 .
2. A device according to claim 1 wherein the electromagnetic radiation and the visible light are pulsed so that they are out of phase so thai the electromagnetic radialion centred at 1072 nm is only emitted when the visible light is not emitted.
3. A device according to either preceding claim including a frequency modulator for phasing the at least one visible light emitting source and the at least one means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1072nm
4. A device according to any preceding claim -that has a bandwidth around 120 nm.
5. A device according to any preceding claim wherein the half angle divergence of the electromagnetic radialion is in the range 15° to 45 °.
6. A device according to any preceding claim further including any one or more of the following features:
ft) means for fixing the intensity of the radiation within a pre-determined range;
(iij an output monitor with a visible display indicating correct function of the device both for intensity and wavelength: and
(iU) means for controlling the duration of the application of the therapy.
7. A device according -to any preceding claim wherein the at least one means Tor emitting divergent narrow bandwidth electromagnetic radiation centred at 1072nm is a solid state light emitting device selected from the group comprising solid state light emitting diodes (LEDs) or gas discharge devices or a laser diode device.
8 A device according to any preceding claim wherein, the means for emttiing divergent narrow bandwidth electromagnetic radiation centred at10 72nm includes a PN junction arranged to emit radiation with a wavelength centring at. or about 1072nm.
9. A device according to any preceding claim wherein, the pulsed electromagnetic radiation is applied at a frequency/re petition rate in the range 300-800 Hz.
10. A device according to any preceding claim, wherein at least one means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1072nm is positioned at a substantially central position on the surface of the interface region and a plurality of means for emitting visible green/cyan tight in the range 470-500 nm are positioned around the10 72nm emitter.
1 1. A device according to any preceding claim further including one or more additional means for emitting visible tight selected from the group comprising red light in the range 700-635 nm. orange light in the range 635-580nm; yellow light in the range 590- Seonm. and blue light in the range 405-470nm.
12. A device according to any preceding claim wherein the minimum pulse width for 1072 nm emission is 300 milHseconds
13 A method for treating and/or improving foody tissues wherein said body tissue has a herpetic infection, the method comprising:
exposing said tissue to divergent electromagnetic radiation at a wavelength centred at 1072 nm so as to coincide witti peak transmissions of a water molecule and visible green-cyan light in the range 470-560 nm: and
selecting a radiation intensity for the electromagnetic radiation capable of producing, at the site of the tissue a radiation fnte nsfty of at least SO u Watts/cm2 up to 2 Watts/cm2
14. A method according to claim 13 wherein the treatment period is between 3 to 10 minutes and is repeated several times a day until symptoms of the infection are alleviated.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862626794P | 2018-02-06 | 2018-02-06 | |
| US62/626,794 | 2018-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2019157033A1 true WO2019157033A1 (en) | 2019-08-15 |
Family
ID=66166522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2019/016814 WO2019157033A1 (en) | 2018-02-06 | 2019-02-06 | Apparatus for and method of treating viral infections |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2019157033A1 (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040193235A1 (en) * | 2001-11-29 | 2004-09-30 | Altshuler Gregory B. | Multi-directional oral phototherapy applicator |
| WO2006134339A1 (en) * | 2005-06-14 | 2006-12-21 | Virulite Distribution Limited | Use of electromagnetic radiation in the treatment of sensory organs |
| US20110178582A1 (en) * | 2008-07-14 | 2011-07-21 | Gordon Dougal | Electromagnetic Radiation And Its Therapeutic Effect |
| US20160067086A1 (en) * | 2014-09-09 | 2016-03-10 | LumiThera, Inc. | Devices and methods for non-invasive multi-wavelength photobiomodulation for ocular treatments |
-
2019
- 2019-02-06 WO PCT/US2019/016814 patent/WO2019157033A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040193235A1 (en) * | 2001-11-29 | 2004-09-30 | Altshuler Gregory B. | Multi-directional oral phototherapy applicator |
| WO2006134339A1 (en) * | 2005-06-14 | 2006-12-21 | Virulite Distribution Limited | Use of electromagnetic radiation in the treatment of sensory organs |
| US20110178582A1 (en) * | 2008-07-14 | 2011-07-21 | Gordon Dougal | Electromagnetic Radiation And Its Therapeutic Effect |
| US20160067086A1 (en) * | 2014-09-09 | 2016-03-10 | LumiThera, Inc. | Devices and methods for non-invasive multi-wavelength photobiomodulation for ocular treatments |
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