WO2019157018A1 - Apparatus for and method of treating viral infections - Google Patents
Apparatus for and method of treating viral infections Download PDFInfo
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- WO2019157018A1 WO2019157018A1 PCT/US2019/016788 US2019016788W WO2019157018A1 WO 2019157018 A1 WO2019157018 A1 WO 2019157018A1 US 2019016788 W US2019016788 W US 2019016788W WO 2019157018 A1 WO2019157018 A1 WO 2019157018A1
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- electromagnetic radiation
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- 238000000034 method Methods 0.000 title claims abstract description 14
- 208000036142 Viral infection Diseases 0.000 title abstract description 4
- 230000009385 viral infection Effects 0.000 title abstract description 3
- 230000005670 electromagnetic radiation Effects 0.000 claims abstract description 33
- 208000015181 infectious disease Diseases 0.000 claims description 12
- 230000005855 radiation Effects 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 7
- 238000002560 therapeutic procedure Methods 0.000 claims description 6
- 208000024891 symptom Diseases 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 4
- 230000005540 biological transmission Effects 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 7
- 238000001126 phototherapy Methods 0.000 description 5
- 241000700584 Simplexvirus Species 0.000 description 4
- 208000001688 Herpes Genitalis Diseases 0.000 description 3
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 3
- 229960004150 aciclovir Drugs 0.000 description 3
- 201000004946 genital herpes Diseases 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 241000700588 Human alphaherpesvirus 1 Species 0.000 description 2
- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000002483 medication Methods 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 241001529453 unidentified herpesvirus Species 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- 241000186427 Cutibacterium acnes Species 0.000 description 1
- 241000589989 Helicobacter Species 0.000 description 1
- 208000029433 Herpesviridae infectious disease Diseases 0.000 description 1
- 241000701074 Human alphaherpesvirus 2 Species 0.000 description 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 description 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 description 1
- 241000701041 Human betaherpesvirus 7 Species 0.000 description 1
- 241001502974 Human gammaherpesvirus 8 Species 0.000 description 1
- 241000701027 Human herpesvirus 6 Species 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010067152 Oral herpes Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241001303601 Rosacea Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 150000001875 compounds Chemical group 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 208000000069 hyperpigmentation Diseases 0.000 description 1
- 230000003810 hyperpigmentation Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 208000037805 labour Diseases 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- 230000007420 reactivation Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 201000004700 rosacea Diseases 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
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- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 238000001429 visible spectrum Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The invention relates to an apparatus for and method of, treating viral infections. The apparatus comprises at least one means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1072nm; and at least one means for emitting visible orange-yellow light in the range 560-635 nm.
Description
APPARATUS FOR AMD METHOD OF TREATING VIRAL INFECTIONS
This invention relates to an apparatus that emits both electromagnetic radiation centred around 1072nm and visible light and method of treating viral infections, in particular, but not exclusively, Herpesviridae infections
BACKGROUND
There are at least eight herpesvirus types that Infect humans: herpes simplex viruses 1 and 2 , varicella-zoster virus, EBV (Epstein-Barr virus), human cytomegalovirus , human herpesvirus 6, human herpesvirus 7, and Kaposi's sarcoma-associated herpesvirus, ali of which are extremely widespread among humans. More than 90% of adults have been Infected with at least one of these, and a latent form of the virus remains in most people.
Herpes simplex viruses are categorized into two main types: herpes type 1 (HSV-1 , or oral herpes) and herpes type 2 (HSV-2, or genital herpes). Most commonly, herpes type 1 infection causes sores around the mouth and lips, although HSV-1 can cause genital herpes, most cases of genital herpes infection are caused by herpes type 2, For many people with the herpes virus , which can go through periods of being dormant, attacks (or outbreaks) can be brought on by the following conditions: general iiiness (from miid illnesses to serious conditions), fatigue, physical or emotional stress, immunosuppression due to AIDS or such medications as chemotherapy or steroids, trauma to the affected area , including sexual activity and menstruation. Furthermore it Is known that UV B light is a potent stimulus for inducing reactivation of latent herpes simplex virus (HSV) infections. When an Individual is first. Infected with herpes and exhibits active symptoms, the duration of the primary outbreak will be the worst and most painful and cars take 3 to 6 weeks to resolve Subsequent recurrent outbreaks will be less severe , typically lasting 3 to 14 days and the frequency will become farther and farther apart with each recurring attack
Electromagnetic radiation is character ized by Its wavelength and its intensity. When the wavelength is within the visible spectrum (approximately from 390nm to 700nm), it is known as "visible light". Electromagnetic radiation less than 300nm is ultraviolet and wavelength greater than 1 ,000 are in the infrared region.
Low level Sight therapy (LLLT) in the red region (635-700nm) has been suggested as an alternative to current medications for accelerated healing, reducing symptoms and
influencing the length of the recurrence period of a herpetic infection . However, it should be noted that a study with 660 nm light as compared to topical applications with acyclovir (the "gold standard" for herpes treatment) showed no difference In the time taken to healing and that a further study of patients treated with acyclovir as the control group as compared to a test group treated with laser phototherapy with 780 nm (far red region) oniy showed that lesion size and inflammation oedema was improved by the light therapy but not the level of pain or monthly recurrence time.
Not ail wavelengths of electromagnetic radiation are beneficial for example infrared radiation at 880 nm is cytotoxic to human lymphocytes in vitro ( Bradford et al J
Photochem. Photobii B; Biology 2005 (81 ) 9-14) whereas electromagnetic radiation centred round 1072nm has a therapeutic effect (W0991 9024). It is aiso known from the prior art that exposure of a herpes infected area of skin to a single restricted bandwidth light centred at 1072 nm, initiated within 36 hours or less of the onset of symptoms, can significantly reduce the healing time of an outbreak as compared to topical applications of acyclovir (Dougal et al Clin Exp Dermatol. 2001 :28 (2): 149-54) and as compared to placebo light (Dougal et al Clin Exp Dermatol. 201 3 , 38:713-718).
Blue light, particularly in the wavelength range of 405-470 nm. has attracted increasing attention due to its intrinsic antimicrobial effect without the addition of exogenous photosensitizers. Blue Sight therapy is a clinically accepted approach for the bacterial infection Propionibacterium acnes and has also been found effective In other bacterial infections such as Helicobacter py/or stomach infections and against, wound pathogenic bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa.
Green light therapy typically fails in the wavelength range of 51 5-520 nrn and is most frequently used for skin treatments such as reducing hyperpigmentation . anti-aging therapies and for sleep disorders. Amber light therapy is also sometimes referred to as yellow or orange light therapy it encompasses the range of wavelengths from 570-620 nm. Amber light has quite a shallow skin penetration but is effective in the treatment of skin issues Involving redness, such as spider veins, rosacea, UV radiation damage, and reducing the appearance of the tiny blood vessels on the nose and face.
A hand held device that could reduce the pain level, provide symptomatic relief, reduce the length of a herpetic infection outbreak and reduce the interval frequency between outbreaks would offer Immediate advantage to individuals afflicted with herpetic infect Ions,
BRiEF SUMMARY OF THE DISCLOSURE
According to a first aspect of the invention there Is provided a hand-held battery operated electromagnetic radiation therapy device comprising
(i) a housing for accommodating the battery ;
(ii) an interface region comprising a surface tor accommodating at least one means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1072nm; and at least one means for emitting visible orange- yeliow irght In the range 560-835 nm,
wherein the device is capable of p reducing, at the site being treated, a radiation intensity of at least 50 μWatts/cm2 and up to 2 Watts/cm2 ·
Preferably, the electromagnetic radiation and the visible light are pulsed so that they are out of phase so that the electromagnetic radiation centred at 1072 nm is only emitted when the visible light is not emitted.
Preferabl y, the device includes a frequency modulator for phasing the at least one visible light emitting source and the at least one means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1072nm so that the visible light from the at least one visible light emitting source Is pulsed out of phase with the infrared light.
Preferably, the device has a bandwidth around 12G nm and the half angle divergence of the electromagnetic radiation is in the range 1 5° to 45°.
Preferably, the device further includes any one or more of the following features:
(i) means for fixing the intensity of the radiation within a pre-determ ined range; iii) an output monitor with a visible display indicating correct function of the device both tor intensity and wavelength:
(iii) means for controlling the duration of the application of the therapy
Preferably, the at least one means of the means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1072nm is a solid state light emitting device selected from the group comprising solid state light emitting diodes (LEDs) or gas discharge devices or a laser diode device.
Preferably, the means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1072nm Includes a PN junction arranged to emit radiation with a wavelength centring at, or about, 1072nm.
Preferably, the pulsed electromagnetic radiation is applied at a frequency/repetition rate in the range 300-800 Hz and more preferably at 60GHz. Preferably, the at least one means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1072nm Is positioned at a substantially central position on the surface of the interface region and a plurality of means for emitting visible orange-yellow in the range 560-635 nm are positioned around the 1072nm emitter. Preferably, the device further includes one or more means for emitting visible light selected from the group comprising red light in the range 635-700nm, , green light in the range 560- 520nm. cyan light in the range 520-490nm and blue light in the range 405-470nm. it will be appreciated that the design of the interface region surface may comprise a number of one means for emitfing divergent narrow bandwidth electromagnetic radiation centred at 1072nm in addition to a number of means for emitting visible orange-yellow Sight in addition to a number of means for emitting other visible lights in the range of 405- 700n NM. Preferably, the minimum pulse width for 1072 nm emission is 300 milliseconds.
According to a further aspect of the invention there is provided a method for treating and/or improving body tissues wherein said body tissue has a herpetic infection, the method comprising:
exposing said tissue to divergent electromagnetic radiation at a wavelength centred at 1 072 nm so as to coincide with peak transmissions of a water molecule and visible orange-yeiiow light in the range 560-635 nm; and
selecting a radiation intensi ty for the electromagnetic radiation capable of producing, at the site of the tissue, a radiation intensity of at least 50 m Watts/cm2 up to 2 Watts/cm 2
The method Includes exposing herpetic viraily infected tissue to the selected electromagnetic radiation and visible light resulting in alley labors of the herpetic virai infection
Preferably, the treatment period is between 3 to 1 0 minutes and may be repeated sever al times a day until the symptoms of the infection are alleviated.
BRIEF DESCRiPTION OF THE DRAWINGS
Embodiments of the invention are further described hereinafter with reference to the accompanying drawings, in which:
Figure 1 is a plan view of one arrangement of the light emitting means on the surface of the interface region
Figure 2 Is a plan view of a different embodiment of Figure 1 .
Figure 3 is a plan view of a yet further embodiment of Figure 1 ,
Figure 4 is a side view of the device of the present invention.
DETAILED DESCRIPTION
Figure 1 shows the surface (1 ) of the interface region, the surface is surrounded by wail (2) which is raised so that the interface surface is protected and in use is kept away from direct skin contact. Arranged on the surface (1 ) in a substantially centrally position is a means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1072nm (3) and arranged around the periphery are a number of blue visible light, emitting means (4a), In use, Item (3) will be on when items (4a) are off, the sequence of on/off can
go clockwise or anticlockwise and alternated between the 1 G72nrn emitter and one of the peripheral orange-yellow or amber light emitters. In the embodiment depicted in Figure 2 there are provided two 1 072 nm emitters (3) although the number can be more and is not. intended to limit the scope of the application Surrounding items (3) there are provided visible orange-yellow emitters (4a) and other visible light emitters (4b). The (4b) emitters can be green or cyan, blue or red and could in some embodiments can be a combination of one, two, three or four different colours or they may be duplicated colours which pulse synchronously or individually in sequence and out of phase with the 1 072nm emiter Figure 3 shows a yet further embodiment where a series of visible light emitters are biue (4a) plus any other visible light <4b, 4c).
With reference to Figure 4 there is shown the hand held device (A) of the present invention . The device comprises a body (5) which accommodates a battery and a panel (6) which has a means for turning the device on and off and which may also comprise a display for assessing duration intensity and other parameters of file treatment
A typical regimen for light exposure, when rising, 1072nm and orange-yellow (amber) light is for four minutes total of at least 300 ms of 1 072nm alternatively with at least 300 ms of blue light.
A typical regimen cycle for multiple light exposure treatment time of around 4 minutes is
I. 1 072nm (300 ms)
I I . Amber light (300ms)
1 1 1 1 072nm (300 ms)
IV. Green light (300ms)
V. 1 072nm (300 ms)
VI. Blue light (300ms)
Optionally the therapy may also include red fight.
Throughout the description and ciaims of this specification, the words "comprise" and “contain" and variations of them mean “including hut not limited to", and they are not intended to (and do not) exclude other moieties, additives, components, integers or steps. Throughout the description and ciaims of this specification , the singular encompasses the
plural unless the context otherwise requires, in particular, where the indefinite article is used, the specification is to be understood as contemplating plurality as well as singularity, unless the context requires otherwise. Features, integers, characteristics, compounds, chemical moieties or groups described in conjunction with a particular aspect, embodiment or example of the invention are to be understood to be applicable to any other aspect, embodiment or exampie described herein unless incompatible therewith. Ail of the features disclosed in this specification (including any accompanying claims, abstract and drawings), and/or all of the steps of any method or process so disclosed , may be combined in any combination , except combinations where at least some of such features and/or steps are mutually exclusive. The invention is not restricted to the details of any foregoing embodiments. The invention extends to any novel one , or any novel combination, of the features disclosed In this specification (including any accompanying claims, abstract and drawings), or to any novel one, or any novel combination , of the steps of any method or process so disclosed.
The reader’s attention is directed to ail papers and documents which are filed concurrently with or previous to this specification in connection with this application and which are open to public inspection with this specification, and the contents of all such papers and documents are incorporated herein by reference.
Claims
1. A hand-held battery operated electromagnetic radiation therapy device comprising :
(I) a housing for accommodati ng the battery;
(ii) an interface region comprising a surface for accommodating at least one means for ernitting divergent narrow bandwidth electromagnetic radiation centred at. 1 072nm ; and at. least one means for emitting visible orange- yellow light in the range 560-635 nm,
wherein the device is capable of producing, at the site being treated, a radiation intensity of at least 50 μVVatts/crn?· and up to 2 Watts/cm2
2. A device according to claim 1 wherein the electromagnetic radiation and the visible light are pulsed so that they are out of phase so that the electromagnetic radiation centred at 1 072 nm Is only emitted when the visible light Is not emitted .
3. A device according to either preceding claim Including a frequency modulator for phasing the at least one visible tight emitting source and the at least one means for emitting divergent narrow bandwidth electromagn etic radiation centred at 1 072nm
4. A device according to any preceding claim that has a bandwidth around 1 20 nm
5 A device according to any preceding claim wherein the half angle divergence of the electromagnetic radiation is in the range 1 5 ° to 45°
6. A device according to any preceding claim further including any one or more of the following features:
(i) means for fixing the intensity of the radiation within a pre-determ ined range;
(ii) an output monitor with a visible display indicating correct function of the device bolth for intensity and wavelength; and
(ill) means for controlling the duration of the application of the therapy
7. A device according to any preceding ciaim wherein, the at least one means for emitting divergent narrow bandwidth electromagnetic radiation centred at l Q72nm is a solid state Sight emitting device selected from the group comprising solid state light emitting diodes (LEDs) or gas discharge devices or a laser diode device.
8 A device according to any preceding claim wherein , the means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1 072nm includes a PN junction arranged to emit radiation with a wavelength centring at, or about, 1 072nm.
9 A device according to any preceding claim wherein, the pulsed electromagnetic radiation is applied at a frequency/repetition rate in the range 300-800 Hz,
1 0. A device according to any preceding claim, wherein at least one means for emitting divergent narrow bandwidth electromagnetic radiation centred at 1 072 nm is positioned at a substantially central position on the surface of the interfac e region and a plurality of means for emitting visible orange-yeliow light in the range 560-635 nm are positioned around the 1 072nm emitter,
1 1 . A device according to any preceding ciaim further including one or more additional means for emitting visible light selected from the group comprising red light in the range 700-635 NM, green light in the range 500-520nm. cyan light in the range 520- 49Qnm and blue light in the range 405-470 nm.
12. A device according to any preceding ciaim wherein the minimum pulse width for
1 072 nm emission is 300 milliseconds
13. A method for treating and/or improving body tissues wherein said body tissue has a herpetic infection, the method com prising:
exposing said tissue to divergent electromagnetic radiation at a wavelength centred at 1 072 nm so as to coincide with peak transmissions of a water molecule and visible blue light in the range 560-635 nm; and
selecting a radiation intensity for the electromagnetic radiation capable of producing, at the site of the tissue, a radiation intensity of at least 50 m Watts/cm2 up to 2 Watts/cm2
14. A method according to claim 1 3 wherein the treatment period is between 3 to 10 minutes and is repeated several times a day until symptoms of the infection are alleviated .
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862626801P | 2018-02-06 | 2018-02-06 | |
| US62/626,801 | 2018-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2019157018A1 true WO2019157018A1 (en) | 2019-08-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2019/016788 WO2019157018A1 (en) | 2018-02-06 | 2019-02-06 | Apparatus for and method of treating viral infections |
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| Country | Link |
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| WO (1) | WO2019157018A1 (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999019024A1 (en) | 1997-10-10 | 1999-04-22 | Virulite Limited | Electromagnetic radiation therapy |
| US20040193235A1 (en) * | 2001-11-29 | 2004-09-30 | Altshuler Gregory B. | Multi-directional oral phototherapy applicator |
| WO2006134339A1 (en) * | 2005-06-14 | 2006-12-21 | Virulite Distribution Limited | Use of electromagnetic radiation in the treatment of sensory organs |
| US20110178582A1 (en) * | 2008-07-14 | 2011-07-21 | Gordon Dougal | Electromagnetic Radiation And Its Therapeutic Effect |
| US20160067086A1 (en) * | 2014-09-09 | 2016-03-10 | LumiThera, Inc. | Devices and methods for non-invasive multi-wavelength photobiomodulation for ocular treatments |
| US9517023B2 (en) * | 2009-06-01 | 2016-12-13 | Profusa, Inc. | Method and system for directing a localized biological response to an implant |
-
2019
- 2019-02-06 WO PCT/US2019/016788 patent/WO2019157018A1/en active Application Filing
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999019024A1 (en) | 1997-10-10 | 1999-04-22 | Virulite Limited | Electromagnetic radiation therapy |
| US20040193235A1 (en) * | 2001-11-29 | 2004-09-30 | Altshuler Gregory B. | Multi-directional oral phototherapy applicator |
| WO2006134339A1 (en) * | 2005-06-14 | 2006-12-21 | Virulite Distribution Limited | Use of electromagnetic radiation in the treatment of sensory organs |
| US20110178582A1 (en) * | 2008-07-14 | 2011-07-21 | Gordon Dougal | Electromagnetic Radiation And Its Therapeutic Effect |
| US9517023B2 (en) * | 2009-06-01 | 2016-12-13 | Profusa, Inc. | Method and system for directing a localized biological response to an implant |
| US20160067086A1 (en) * | 2014-09-09 | 2016-03-10 | LumiThera, Inc. | Devices and methods for non-invasive multi-wavelength photobiomodulation for ocular treatments |
Non-Patent Citations (2)
| Title |
|---|
| DOUGAL ET AL., CLIN EXP DERMATOL., vol. 26, no. 2, 2001, pages 149 - 54 |
| DOUGAL ET AL., CLIN EXP DERMATOL., vol. 38, 2013, pages 713 - 718 |
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