WO2019156684A1 - Méthode, système et appareil de production de peroxyde d'hydrogène - Google Patents
Méthode, système et appareil de production de peroxyde d'hydrogène Download PDFInfo
- Publication number
- WO2019156684A1 WO2019156684A1 PCT/US2018/017786 US2018017786W WO2019156684A1 WO 2019156684 A1 WO2019156684 A1 WO 2019156684A1 US 2018017786 W US2018017786 W US 2018017786W WO 2019156684 A1 WO2019156684 A1 WO 2019156684A1
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- WIPO (PCT)
- Prior art keywords
- hydrogen peroxide
- aqueous solution
- semi
- production
- enzyme
- Prior art date
Links
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 title claims abstract description 247
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 108
- 238000000034 method Methods 0.000 claims abstract description 62
- 239000012528 membrane Substances 0.000 claims abstract description 45
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims abstract description 41
- 150000001875 compounds Chemical class 0.000 claims abstract description 31
- 239000007864 aqueous solution Substances 0.000 claims abstract description 26
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims abstract description 23
- 238000006479 redox reaction Methods 0.000 claims abstract description 10
- 230000004888 barrier function Effects 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims abstract description 8
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 claims abstract 7
- 102000004190 Enzymes Human genes 0.000 claims description 17
- 108090000790 Enzymes Proteins 0.000 claims description 17
- 239000000126 substance Substances 0.000 claims description 11
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 claims description 8
- 150000004056 anthraquinones Chemical class 0.000 claims description 8
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims description 7
- KJYPAIRTXRKKHG-UHFFFAOYSA-N 1,4,6-trimethyl-9h-pyrido[3,2-g]quinoline-2,5,8,10-tetrone Chemical compound O=C1C(N(C(=O)C=C2C)C)=C2C(=O)C2=C1NC(=O)C=C2C KJYPAIRTXRKKHG-UHFFFAOYSA-N 0.000 claims description 6
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims description 6
- FKUYMLZIRPABFK-UHFFFAOYSA-N Plastoquinone 9 Natural products CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCC1=CC(=O)C(C)=C(C)C1=O FKUYMLZIRPABFK-UHFFFAOYSA-N 0.000 claims description 6
- 229960003159 atovaquone Drugs 0.000 claims description 6
- KUCQYCKVKVOKAY-CTYIDZIISA-N atovaquone Chemical compound C1([C@H]2CC[C@@H](CC2)C2=C(C(C3=CC=CC=C3C2=O)=O)O)=CC=C(Cl)C=C1 KUCQYCKVKVOKAY-CTYIDZIISA-N 0.000 claims description 6
- JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical class C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 claims description 6
- FKUYMLZIRPABFK-IQSNHBBHSA-N plastoquinone-9 Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC1=CC(=O)C(C)=C(C)C1=O FKUYMLZIRPABFK-IQSNHBBHSA-N 0.000 claims description 6
- MMXZSJMASHPLLR-UHFFFAOYSA-N pyrroloquinoline quinone Chemical compound C12=C(C(O)=O)C=C(C(O)=O)N=C2C(=O)C(=O)C2=C1NC(C(=O)O)=C2 MMXZSJMASHPLLR-UHFFFAOYSA-N 0.000 claims description 6
- PVYJZLYGTZKPJE-UHFFFAOYSA-N streptonigrin Chemical compound C=1C=C2C(=O)C(OC)=C(N)C(=O)C2=NC=1C(C=1N)=NC(C(O)=O)=C(C)C=1C1=CC=C(OC)C(OC)=C1O PVYJZLYGTZKPJE-UHFFFAOYSA-N 0.000 claims description 6
- CWFOAASSUQIXOW-UHFFFAOYSA-N 10,11,12,13,14,16-hexazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,12,14-heptaen-8-one 10,12,13,14,15,16-hexazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,11,13-heptaen-8-one Chemical compound N1=C2C(=O)C3=CC=CC=C3C2=NN2N=NN=C21.N1=C2C(=O)C3=CC=CC=C3C2=NC2=NN=NN21 CWFOAASSUQIXOW-UHFFFAOYSA-N 0.000 claims description 3
- PFRQBZFETXBLTP-RCIYGOBDSA-N 2-[(2e,6e,10e,14e,18e)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-3-methyl-1,4-dihydronaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-RCIYGOBDSA-N 0.000 claims description 3
- XVXDZGBARWYTHG-UHFFFAOYSA-N 4,6-dimethyl-1-(2-methylpropyl)-9h-pyrido[3,2-g]quinoline-2,5,8,10-tetrone Chemical compound N1C(=O)C=C(C)C2=C1C(=O)C(N(C(C=C1C)=O)CC(C)C)=C1C2=O XVXDZGBARWYTHG-UHFFFAOYSA-N 0.000 claims description 3
- SHHKQEUPHAENFK-UHFFFAOYSA-N Carboquone Chemical compound O=C1C(C)=C(N2CC2)C(=O)C(C(COC(N)=O)OC)=C1N1CC1 SHHKQEUPHAENFK-UHFFFAOYSA-N 0.000 claims description 3
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims description 3
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 claims description 3
- HRHKSTOGXBBQCB-UHFFFAOYSA-N Mitomycin E Natural products O=C1C(N)=C(C)C(=O)C2=C1C(COC(N)=O)C1(OC)C3N(C)C3CN12 HRHKSTOGXBBQCB-UHFFFAOYSA-N 0.000 claims description 3
- 229930003448 Vitamin K Natural products 0.000 claims description 3
- 229960002115 carboquone Drugs 0.000 claims description 3
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 3
- 235000017471 coenzyme Q10 Nutrition 0.000 claims description 3
- GHHZELQYJPWSMG-UHFFFAOYSA-N dibromothymoquinone Chemical compound CC(C)C1=C(Br)C(=O)C(C)=C(Br)C1=O GHHZELQYJPWSMG-UHFFFAOYSA-N 0.000 claims description 3
- HRHKSTOGXBBQCB-VFWICMBZSA-N methylmitomycin Chemical compound O=C1C(N)=C(C)C(=O)C2=C1[C@@H](COC(N)=O)[C@@]1(OC)[C@H]3N(C)[C@H]3CN12 HRHKSTOGXBBQCB-VFWICMBZSA-N 0.000 claims description 3
- 229960004857 mitomycin Drugs 0.000 claims description 3
- MBWXNTAXLNYFJB-LKUDQCMESA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCCC(C)CCCC(C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-LKUDQCMESA-N 0.000 claims description 3
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 3
- 235000019175 phylloquinone Nutrition 0.000 claims description 3
- 239000011772 phylloquinone Substances 0.000 claims description 3
- 229950004406 porfiromycin Drugs 0.000 claims description 3
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 claims description 3
- UGNWTBMOAKPKBL-UHFFFAOYSA-N tetrachloro-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O UGNWTBMOAKPKBL-UHFFFAOYSA-N 0.000 claims description 3
- 229940035936 ubiquinone Drugs 0.000 claims description 3
- 235000019168 vitamin K Nutrition 0.000 claims description 3
- 239000011712 vitamin K Substances 0.000 claims description 3
- 150000003721 vitamin K derivatives Chemical class 0.000 claims description 3
- 229940046010 vitamin k Drugs 0.000 claims description 3
- 229940068088 vitamin k 1 Drugs 0.000 claims description 3
- 229940010250 vitamin k 2 Drugs 0.000 claims description 3
- 229940041603 vitamin k 3 Drugs 0.000 claims description 3
- QZPQTZZNNJUOLS-UHFFFAOYSA-N beta-lapachone Chemical compound C12=CC=CC=C2C(=O)C(=O)C2=C1OC(C)(C)CC2 QZPQTZZNNJUOLS-UHFFFAOYSA-N 0.000 claims description 2
- 101000973778 Homo sapiens NAD(P)H dehydrogenase [quinone] 1 Proteins 0.000 abstract 4
- 102100022365 NAD(P)H dehydrogenase [quinone] 1 Human genes 0.000 abstract 4
- 239000012224 working solution Substances 0.000 description 45
- 230000008569 process Effects 0.000 description 18
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 14
- 239000000463 material Substances 0.000 description 10
- 229950006238 nadide Drugs 0.000 description 10
- 239000001301 oxygen Substances 0.000 description 10
- 229910052760 oxygen Inorganic materials 0.000 description 10
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 description 9
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 9
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 8
- 238000010586 diagram Methods 0.000 description 8
- 150000004053 quinones Chemical class 0.000 description 8
- 239000001257 hydrogen Substances 0.000 description 7
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 6
- 238000004891 communication Methods 0.000 description 6
- -1 cyclic ester Chemical class 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 150000005208 1,4-dihydroxybenzenes Chemical class 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 239000003054 catalyst Substances 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 4
- 238000012423 maintenance Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 238000005086 pumping Methods 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 239000006172 buffering agent Substances 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 150000002431 hydrogen Chemical class 0.000 description 3
- 238000005984 hydrogenation reaction Methods 0.000 description 3
- 229910052763 palladium Inorganic materials 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000033116 oxidation-reduction process Effects 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 101710131282 FAD-linked oxidoreductase easE Proteins 0.000 description 1
- 241001559542 Hippocampus hippocampus Species 0.000 description 1
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 description 1
- 101710199728 Oxidoreductase 1 Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001491 aromatic compounds Chemical class 0.000 description 1
- 238000006701 autoxidation reaction Methods 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 125000000687 hydroquinonyl group Chemical group C1(O)=C(C=C(O)C=C1)* 0.000 description 1
- 150000004336 hydroxyquinones Chemical class 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 150000004059 quinone derivatives Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B15/00—Peroxides; Peroxyhydrates; Peroxyacids or salts thereof; Superoxides; Ozonides
- C01B15/01—Hydrogen peroxide
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/243—Dialysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/28—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/30—Accessories; Auxiliary operation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/32—Controlling or regulating
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B15/00—Peroxides; Peroxyhydrates; Peroxyacids or salts thereof; Superoxides; Ozonides
- C01B15/01—Hydrogen peroxide
- C01B15/013—Separation; Purification; Concentration
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B15/00—Peroxides; Peroxyhydrates; Peroxyacids or salts thereof; Superoxides; Ozonides
- C01B15/01—Hydrogen peroxide
- C01B15/022—Preparation from organic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P3/00—Preparation of elements or inorganic compounds except carbon dioxide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
- C12Y106/05—Oxidoreductases acting on NADH or NADPH (1.6) with a quinone or similar compound as acceptor (1.6.5)
- C12Y106/05002—NAD(P)H dehydrogenase (quinone) (1.6.5.2)
Definitions
- the hydrogen peroxide is typically produced using a cyclical anthraquinone process (AO-process) comprising the hydrogenation of anthraquinone working solution in a catalytic reactor and the oxidation of the hydrogenated anthraquinone working solution by air in a multi-stage packed bed or sieve plate tower while simultaneously producing hydrogen peroxide in the organic stream, with the consecutive extraction of the hydrogen peroxide from the anthraquinone working solution by water in a multistage counter-current extraction column process.
- AO-process cyclical anthraquinone process
- the organic solvent of choice is typically a mixture of two types of solvents, one being a good solvent of the quinone derivative (usually a mixture of aromatic compounds) and the other being a good solvent of the hydroxyquinone derivative (usually a long chain alcohol or cyclic ester).
- ancillary process steps such as the separation of the hydrogenation catalyst from the working solution; the recovery and polish purification of the anthraquinone working solution, the accompanying solvents, their recycle to the hydrogenator, and the recovery, polish purification and
- the AO-process may be performed on small-to medium-scale so as to merely satisfy local demand, in the state of the art it is still deemed that such processes require the use of many pieces of equipment, much management attention, and frequent maintenance, and that they are difficult to scale down and difficult to make such processes profitable.
- a hydrogen peroxide production method, system, and apparatus for producing large volumes of hydrogen peroxide having concentrations up to and excess of 80% in one continuous cycle.
- the hydrogen peroxide production system can be set-up and installed using simple and cost-effective components.
- the production system and unit may be modular, compact, portable, simple to operate, and require minimal maintenance.
- an enzymatic method and process for the continual manufacturing of hydrogen peroxide at room temperature in a single, on-site or stand-alone reactor or production chamber is provided.
- the method can include NAD(P)H:qunone oxidoreductase 1 (NQ01) mediated reduction of a single working solution having at least one NQ01 -activated compound (NAC) to generate an unstable semiquinone intermediately that spontaneously re-generates the parent NAC and
- a working solution is provided a working solution is provided that contains excess reduced nicotinamide adenine dinucleotide (NADH), allowing the reaction to persist indefinitely while the parent NAC continuously re- generates.
- NADH nicotinamide adenine dinucleotide
- the method can be processed within a molecular weight -specific semi- permeable dialysis membrane that allows the diffusion of hydrogen peroxide there through while preventing the constituents of the working solution to pass through.
- the resulting hydrogen peroxide can be collected in an aqueous solution at a collection chamber. The collected hydrogen peroxide solution can be continuously pumped through and over the membrane, thereby creating an increasingly concentrated hydrogen peroxide solution exceeding 80% wt hydrogen peroxide per reaction membrane in a 12 hour run-time production cycle.
- the membrane, pump, and collection chamber can be housed together as one production unit.
- the production unit may also be modular in design wherein any number of production chambers, membranes, collection chambers, valves, and components in any configuration.
- the production unit may operate at room temperature with minimal energy requirements to operate the pump.
- the hydrogen peroxide production method and system may operate with a production capacity of up to 20 kilo tons of hydrogen peroxide solution per year.
- the production method can be configured to operate continuously with NADH with a production capacity of hydrogen peroxide in the range of 2 to 15 ktpa capacity.
- a method of manufacturing hydrogen peroxide can include mixing NQ01 enzyme, an NQ01 activated compound or molecule, and an NADH or NADPH cofactor with an aqueous solution, dispensing the aqueous solution within or onto a semi-permeable membrane, wherein the semi-permeable membrane further including a pre-defined molecular weight barrier.
- the method further includes wherein an oxidation-reduction reaction of the NQ01 enzyme, the NQ01 activated compound or molecule, and the NADH or NADPH cofactor within the aqueous solution produce hydrogen peroxide at a concentration level, and wherein the produced hydrogen peroxide is above the pre-defined molecular weight barrier of the semi-permeable membrane, and diffuses through the semi-permeable membrane.
- the method can further include extracting the produced hydrogen peroxide for retrieval at a collection chamber.
- the method can also include circulating the produced hydrogen peroxide through the membrane to produce a second concentration level of the hydrogen peroxide.
- the method can include dispensing one or more additional NQ01 enzyme, NQ01 activated compound, and NAD(P)H (or NADH cofactor or NADPH cofactor) into the aqueous solution.
- NQ01 activated compound can include one or more of: quinones, b-lapachone, streptonigrin, deoxynyboquinone, isobutyl-deoxynyboquinone, mitomycin C, KP372-1 , phenothiazinium compounds, 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1 ,4-benzoquinone (RH1),
- apaziquinone (E09), indolquinones, pronoqodine A, quinolinoquinones, binaphtoquinones; and possibly Anthraquinone, Plastoquinone, Pyrroloquinoline quinone, Carbazilquinone, Chloranil, Dibromothymoquinone, Plastoquinone, Ubiquinone, Indolequinones, Porfiromycin,
- the aqueous solution can include H 2 0 and Tris-HCL.
- the concentration level of the produced hydrogen peroxide can be 30% or more.
- the oxidation-reduction reaction can be a continuous cycle with 90% or more efficiency having 10% or less loss of the original NQ01 enzyme, NQ01 activated compound or molecule, and NADH or NADPH cofactors.
- a hydrogen peroxide production system can include an aqueous solution comprised of an NQ01 enzyme, an NQ01 activated compound or molecule, and an NADH or NADPH cofactor for producing hydrogen peroxide.
- the system further includes a production chamber having a semi-permeable membrane for receiving the aqueous solution.
- the membrane can further include one or more molecular weight barriers configured to diffuse the produced hydrogen peroxide there through.
- the system can also include a collection chamber for retrieving the produced hydrogen peroxide, and one or more pumps for circulating the aqueous solution having the hydrogen peroxide to the collection chamber and back to the production chamber.
- the molecular weight barrier can be at least 100 Daltons.
- the system may also include a testing chamber for testing the produced hydrogen peroxide concentration levels.
- the semi-permeable membrane can also have a tubular configuration.
- the semi-permeable membrane can be at least partially suspended within the production chamber.
- the system may further include a plurality of semi-permeable membranes.
- the system can also include a plurality of production chambers configured in parallel or series
- production chamber, collection chamber, and pump can be portable and modular units or assembled as one portable and mobile unit.
- a method of manufacturing hydrogen peroxide can include mixing one or more NQ01 enzymes, one or more NQ01 activated compounds, and a third substance.
- the mixing can result in an oxidation-reduction reaction thereby producing hydrogen peroxide in a continuous cycle.
- the third substance can be an NADH or NADPH cofactor.
- the third substance can also be hydrogen (H 2 ) gas and a platinum or palladium (Pd) catalyst.
- FIG. 1A illustrates a diagram for one non-limiting embodiment of a chemical reaction for the hydrogen peroxide production system and method of the disclosure described herein.
- FIG. 1 B illustrates a chemical reaction equation for the embodiment of FIG. 3A.
- F I G . 1 C-1 D illustrate data charts of sample experiment data for one exemplary testing of hydrogen peroxide produced using the hydrogen peroxide production system and method of the disclosure described herein.
- FIG. 1 E illustrates another non-limiting embodiment of a diagram for a hydrogen peroxide production system and method of the disclosure described herein.
- FIG. 2A illustrates a cross-sectional side view of one non-limiting embodiment for a hydrogen peroxide production chamber of the disclosure described herein.
- FIG. 2B illustrates a cross-sectional top view of one non-limiting embodiment for the hydrogen peroxide production chamber of the disclosure described herein.
- FIG. 2C illustrates a partial cross sectional side view of a semi-permeable membrane of the production chamber.
- FIG. 3 illustrates a schematic diagram for one non-limiting embodiment of the hydrogen peroxide production system and method of the disclosure described herein.
- FIG. 4 illustrates a block diagram for one non-limiting embodiment for a process of producing hydrogen peroxide for the hydrogen peroxide production system and method of the disclosure described herein.
- FIG. 5 illustrates a schematic diagram for another non-limiting embodiment of a production system for the hydrogen peroxide production system and method of the disclosure described herein.
- FIG. 6 illustrates a schematic diagram for another non-limiting embodiment of a production system for the hydrogen peroxide production system and method of the disclosure described herein.
- FIG. 7 illustrates a schematic diagram for another non-limiting embodiment of a production system for the hydrogen peroxide production system and method of the disclosure described herein.
- FIG. 8 illustrates a schematic diagram for another non-limiting embodiment of a production system for the hydrogen peroxide production system and method of the disclosure described herein.
- FIG. 9 illustrates a front elevated perspective view for one non-limiting embodiment of a portable hydrogen peroxide production apparatus of the disclosure described herein having modular components.
- FIG. 10A illustrates a top view for one non-limiting embodiment of a portable hydrogen peroxide production apparatus of the disclosure described herein as one single-unit.
- FIG. 10B illustrates a partial side view for the embodiment of FIG. 10A
- FIGS. 1A-1 B illustrate one embodiment for the hydrogen peroxide production method and system of the present disclosure described herein using an oxidation-reduction reaction.
- the production method can use raw source material, solution, substances, molecules, or compositions that can include one or more of NQ01 activated compounds (NACs), NQ01 , NADFI or NADPFI.
- NACs NQ01 activated compounds
- NADFI NADPFI
- NADFI may also be represented as NAD(P)FI.
- NQ01 is a two-electron oxidoreductase enzyme found in living, biological systems that can utilize the hydrogen atoms from NADPFI or NADFI co-factors to hydrogenate quinones to a stable hydroquinone intermediate.
- NACs NQ01 activated compounds
- NADH is generally known as nicotinamide-adenine-dinucleotide in its reduced form
- NADPH is generally known as nicotinamide-adenine-dinucleotide-phosphate in its reduced form.
- the NADH and NADPH substances are cofactors for a variety of enzymes, the majority of which catalyze oxidation-reduction reactions, such as NQ01 .
- the NQ01 enzyme operates as a catalyst by removing two hydrogen atoms from the NADPH or NADH cofactors and adds these hydrogen molecules to one or more NACs which then results in an un-stable hydroquinone, as shown in FIG. 1A.
- NADPH is oxidized thus reducing to NADP + .
- NADH can also be oxidized thus reducing to NAD + .
- an NAC such as b-Lacaphone is mixed into a working solution in combination with NQ01 and NAD(P)H.
- the NQ01 oxidizes the NAD(P)H to NAD(P) + by removing hydrogen atoms from the NAD(P)H and adding the hydrogen atoms to the b-Lacaphone quinone compound.
- This oxidation-reduction process then results in one or more hydroquinones, which are generally extremely un-stable molecules. From here, the chemical reaction proceeds wherein oxygen from an atmospheric environment donates an electron to the hydroquinones.
- oxygen (0 2 ) becomes a superoxide anion radical (0 2 ) which then produces one or more un-stable semiquinones.
- the superoxide radical (0 2 ) then spontaneously reacts with water (H 2 0), wherein the superoxide radical reacts with a proton donated from water and is converted to hydrogen peroxide (H 2 0 2 ) and oxygen (0 2 ).
- the semiquione accepts or receives an electron from oxygen (0 2 ) molecule, generating another superoxide radical (0 2 ) which then forms hydrogen peroxide (H 2 0 2 , and regenerates the b-Lacaphone parent quinone compound in a continuous cycle fueled by NAD(P)H.
- the resulting hydrogen peroxide can then be extracted from the working solution.
- NAC NAC’s or quinones
- These NAC’s may also be naturally occurring or man- made using non-natural synthentic processes.
- NAC nucleophilicity factor
- B-lapachone streptonigrin
- deoxynyboquinone isobutyl-deoxynyboquinone
- mitomycin C KP372-1
- phenothiazinium compounds 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1 ,4-benzoquinone (RH1)
- apaziquinone E09
- indolquinones pronoqodine A
- quinolinoquinones quinolinoquinones
- binaphtoquinones and possibly Anthraquinone, Plastoquinone, Pyrroloquinoline quinone, Carbazilquinone, Chloranil, Dibromothymoquinone, Plastoquinone, Ubiquinone,
- FIG. 1 C-1 D data graphs are provided illustrating the results of one sample experiment for hydrogen peroxide produced using the one or more embodiments of the present disclosure described herein.
- FIG. 1 C illustrates the generation of superoxide radicals by using the Oxygen Consumption Rate (OCR) with respect to time as a proxy for one experiment.
- OCR Oxygen Consumption Rate
- the experiment comprised using a Seahorse Bioscience XF Analyzer® instrument to measure the OCR with respect to time.
- each well was filled with 140 microliters of 100 units of NQ01 , NADH, 4 micromolar NAC (b -Lacaphone), 50 millimolar Tris-HCI at pH 7 wherein the solutions were kept at atmospheric temperature.
- each well had an optical sensor for measuring the oxygen content thereby providing an effective OCR with respect to time.
- OCR OCR in the wells incubated with B-lapachone dramatically increased and sustained OCR, while control wells treated with the vehicle dimethyl sulfoxide (DMSO) did not change baseline OCR levels (FIG.
- DMSO vehicle dimethyl sulfoxide
- FIG. 1 E illustrates another embodiment for a hydrogen peroxide production method and system of the present disclosure described herein.
- an NAC such as b- Lacaphone is used in a working solution 310 in combination with hydrogen (hi 2 ) gas and platinum or palladium (Pd) to produce hydrogen peroxide without the use of NG01 or
- the palladium (Pd) operates as a catalyst by using hydrogen gas bubbled through the apparatus to hydrogenate both ketones present in B-lapachone to the
- the semiquione then accepts or receives an electron from an oxygen (0 2 ) molecule thereby re- making the b-Lacaphone quinone compound and further generating superoxide radical/hydrogen peroxide in a continuous cycle limited only by the amount of H 2 gas available.
- the resulting hydrogen peroxide can then be extracted from the working solution.
- FIG. 2A-2C illustrate one embodiment for a production chamber of the hydrogen peroxide production system and method of the present disclosure described herein.
- the production chamber 102 can include a tubular housing 202 that further houses a tubular dialysis membrane 204.
- housing 202 further includes end caps 220 and 220, for receiving and sending a working solution 300.
- end cap 220 includes an inlet port 210 for receiving the circulating working solution 300 and an inlet injection port 212 for receiving one or more raw or source materials, substances, or compounds of the working solution 300, such as raw or source materials NQ01 , Hydrogen (H 2 ), NAC/quinones, and NADH/NADPH, among others.
- an injection syringe needle 250 is shown for injecting the source materials for the working solution 300 into the inlet injection port 212, however, it is contemplated within the scope of the invention than any other injection or dispensing apparatus or system may be used for injecting or dispensing the working solution 300 or source materials for the working solution to and within membrane 204 and housing 202.
- the injected and circulating working solution can travel through inlets 210 and 212 and directly within the interior space 206 of tubular membrane 204.
- membrane 204 can either be suspended or freely floating within housing 202, or in the alternative, membrane 204 can be coupled or fixed to housing 202.
- membrane 204 can have a specified or pre-determined molecular weight barrier cut-off. More specifically, any substance, compound, solution, or molecules within the interior chamber space 206 of membrane 204 that are larger in molecular weight than the specified or pre-determined cut-off will be trapped within space 206 of membrane 204. In contrast, any substance, compound, solution, or molecules that are less than the pre-determined cut-off will diffuse through the membrane.
- membrane 204 is made of a semi-permeable material that can have a pre-defined 100 Dalton molecular weight cut-off, however, it is contemplated within the scope of the invention that any suitable molecular weight cut-off may also be used, including but not limited to 50 Daltons through 150,000 Daltons.
- the NQ01 and NAC/quinones of the present disclosure described herein have a molecular weight that is larger than the specified cut-off for the membrane (i.e. larger than 100 Daltons), hence, the NQ01 , NAC/quinones, and NAD7NADP + of the working solution 300 are trapped within membrane 204 and do not diffuse through.
- the resulting byproduct of the NQ01 the resulting byproduct of the NQ01 ,
- NAC/quinones, and NAD/NADP reaction is hydrogen peroxide, wherein hydrogen peroxide has a molecular weight that is less than the pre-determined or specified molecular weight of membrane 204 (i.e. less than 100 Daltons). Hence, hydrogen peroxide will subsequently diffuse through membrane 204 and out to the interior space of housing 202, wherein the resulting working solution 300 (which now includes the hydrogen peroxide concentration), is pumped out of the housing through outlet 214 and to one or more collection chambers or for additional processing and circulation.
- one or more raw source materials may be periodically, intermittently, or continuously injected or dispensed within one or more of membrane 204, housing 202, and production chamber 102.
- the initial working solution 300 or the raw source materials, prior to producing hydrogen peroxide, can be comprised of a buffering agent/substance/compound, spring or distilled water, ethylene, Tris, or Tris-Hydrochloride (Tris-HCI), among others.
- Tris-HCI Tris-Hydrochloride
- the initial working solution 300 having the buffering agent or Tris-HCI may be within storage chamber 108 or collection chamber 104, wherein the initial working solution 300 is pumped out of either chamber 108 or 104 and into production chamber 102, thereby adding, producing, and increasing the hydrogen peroxide concentration of the working solution 300.
- FIG. 3 illustrates one non-limiting embodiment for a hydrogen peroxide production method, system, and apparatus 100 of the disclosure described herein.
- the hydrogen peroxide production system 100 can be a closed-loop system that can include a production chamber 102 that receives source, raw, or working solutions 300 from a storage source 108.
- the system further includes one or more peristaltic pumps 150 for circulating and re-circulating the working solution and the H 2 0 2 solution within the system.
- any type of fluid or positive displacement pump may be used.
- the system includes a collection chamber 104 for receiving, storing, collecting, and dispensing the H 2 0 2 to a batch or packaging 130.
- the collection chamber may also store the initial working solution prior to commencing a cycle, with or without a hydrogen peroxide concentration.
- the system can further include a testing chamber 106 for simultaneously or periodically testing the concentration and purity of the working solution or H 2 0 2 circulating through the system, and one or more gauge readouts 122 for detecting the flow rate, pressures, temperatures, and other thermodynamic or chemical properties of the system and H 2 0 2 circulating within the system.
- the production system 100 can further include a plurality of valves 110, 112, 114, 116, 118, and 120 for controlling the flow rate, bypass, shut-off, or isolation of one or more units, components, and chambers within the production system.
- any type of manual or automatic valve may be used within the production system, including but not limited to gate valves, one-way/two-way/three-way valves, butterfly valves, glob valves, piston valves, solenoid valves, and ball valves, among others.
- chambers 102, 104, 106, and 108 may be of any size, dimension, or volumetric capacity.
- FIG. 4 illustrates one embodiment for a method of operation of the hydrogen peroxide production system and method of the disclosure described herein.
- the process can start at step 400, wherein raw source materials or initial working solution are introduced into the production chamber of the system.
- one or more pumps within the system may be programmed or receive operational parameters for running one or more hydrogen production pumping cycles.
- the pump may include one or more control units, controllers,
- a user may define or schedule a timed operation within a timer or scheduling module of the pump, such as start/stop times, day/month/year, daily, monthly, yearly, single-use, or periodic operations.
- a timer or scheduling module of the pump such as start/stop times, day/month/year, daily, monthly, yearly, single-use, or periodic operations.
- the user may also define or set a constant or variable flow-rate for the pump operation.
- user may also define or set a desired threshold hydrogen peroxide concentration or volume levels.
- the pump may continue to operation and re-circulate the working solution within the system until a pre-defined or user-defined hydrogen peroxide concentration level is reached, and wherein the pump may shut-off automatically, or in the alternative, notify or alert one or more users.
- the pump may also include a testing module for automatically, periodically, or continuously testing the hydrogen peroxide concentration levels of the working solution passing through the pump.
- the pump may also include a progress indicator for indicating various factors, including but not limited to: current concentration levels, desired concentration levels, flow rate, estimated time remaining until completion of one or more production cycles, temperatures, environmental conditions, stable or un-stable conditions, and any notifications, alerts, or errors, among others.
- the pump may include functionality for automatic, semi-automatic, or manual operation.
- step 406 the process can proceed to step 408.
- step 408 the process can commence the hydrogen production cycle. It is contemplated within the scope of the invention that each cycle can operate continuously in operation from one (1) minute up to and including 365 days, depending on the intended application, use, volume, and desired hydrogen peroxide concentration levels.
- step 410 once the one or more pre-defined or threshold parameters are reached, the process may then proceed to step 412, wherein the pump and production system may automatically shut- off, rest, or repeat the cycle after a pre-determined time.
- the working solution batch having the hydrogen peroxide composition may be extracted, removed, dispensed, or packaged for distribution. Alternatively, the working solution batch may be re- introduced back into the production system in full or in part for additional hydrogen peroxide production.
- FIG. 5 illustrates another embodiment for a hydrogen peroxide production system of the disclosure described herein.
- the system may include a plurality of production chambers 5102 connected in parallel and a plurality of valves 5120 controlling the input to the chambers.
- One or more of the chambers 5102 may be operational at any given time depending on the intended use, application, volume, and hydrogen peroxide
- the system may also include a first pump 5150A and second pump 5150B in order to further provide additional flow rate and assure constant pump head pressure throughout the system for circulating the working solution.
- the system may include a collection chamber 5104, wherein the resulting hydrogen peroxide batch 5130 may be recovered. It is contemplated within the scope of the invention that any one or more valves or components may also be incorporated into the system of FIG. 5.
- FIG. 6 illustrates another embodiment for a hydrogen peroxide production system of the disclosure described herein.
- the system may include a plurality of production chambers 6102 connected in a series configuration wherein a plurality of pumps 6150A and 6150B further circulate the working solution through a collection chamber 6104, wherein the working solution containing hydrogen peroxide batch 6130 may be recovered.
- the addition of production chambers connected in series can further help amplify the hydrogen peroxide production chemical reaction within the production chambers.
- the addition of additional production chambers can further help purify the working solution.
- FIG. 7 illustrates another embodiment for a hydrogen peroxide production system of the disclosure described herein.
- the system may include a production chamber 7102 in communication with a first collection chamber 7104A and a second collection chamber 7104B.
- pre-defined volume or percentage of the working solution may be diverted to collection chamber 7104B via opening of valve 7120B and operation of pump 7150B thereby directing the working solution to collection chamber 7104B to be later recovered as batch 7130B.
- the remaining working solution within the system may continue to circulate through pump 7150A, collection chamber 7104A and back through production chamber 7102.
- any one or more valves or components may also be incorporated into the system of FIG. 7.
- FIG. 8 illustrates another embodiment for a hydrogen peroxide production system of the disclosure described herein.
- the system may be a two-part system that can work in unison with each other or independent of each other.
- system A may include a production chamber 8102A that may be isolated from system B by closing valves 8120A and 8122A.
- Such a two-part system may be used in a production system wherein two or more separate hydrogen peroxide concentration levels or volumes may be desired.
- system B may be isolated from system A via closing of valves 8120B and 8122B.
- Each system can include its own independent pumping systems and collection chambers. It is contemplated within the scope of the invention that any one or more valves or components may also be incorporated into the system of FIG. 8.
- FIG. 9 illustrates one embodiment for a hydrogen peroxide production apparatus having modular components.
- the production apparatus 900 can include a tubular production chamber 9102 having a tubular semi-permeable membrane 9104 freely suspended or fixed therein.
- production chamber 9102 may also be configured in an upright position and secured via a holder or stand 9110.
- the production chamber is in fluid communication pump 9150, wherein pump 9150 further include a user interface for 9152 for setting various parameters of the pump operation, including but not limited to a timed operation, hydrogen peroxide concentration desired level, on/off, flow rate, manual, automated, or pre-programmed operations and schedules, among others.
- Pump 9150 is also in fluid communication with collection chamber 9130, for circulating and pumping the aqueous solution from production 9102 to collection chamber 9130.
- collection chamber 9130 is also in fluid communication with production chamber 9102, wherein pump 9150 can pump and circulate the contents or aqueous solution of collection chamber 9130 to production chamber 9102.
- the pump may circulate the aqueous solution via any type of flexible or rigid tubing or piping.
- FIG. 10A-10B illustrate another embodiment for the hydrogen peroxide production system and apparatus of the disclosure described herein configured as a single portable and mobile unit.
- FIG. 10A illustrates a top view of the portable unit 10000, wherein a top cover is removed, thereby illustrating some of the interior components.
- unit 10000 can include a casing or housing 10100 for enclosing a production chamber 10102, semi-permeable membrane 10104 within the production chamber, collection chamber 10106, raw source reservoir 10108, pump 10150, user interface 10152, tubes 10202, 10204, and 10206, controller or control unit 10400, and a power source 10402, among others.
- controller 10400 can include a microprocessor, memory, storage device, logic, software, application, algorithm, and programming stored thereon, among others, for controlling operation of the hydrogen peroxide production method, system, and apparatus of the disclosure described herein.
- logic, software, application, algorithm, and programming may include any non-transitory computer readable medium storing thereon a program, which when executed by a computer, causes the computer to perform a method or function.
- controller 10400 can further electrically communicate and send/receive commands with pump 10150, graphical user interface 10152, reservoir 10108, production chamber 10102, and collection chamber 10108.
- tube 10204 is in fluid communication with production chamber 10102 wherein its contents are outputted to pump 10150 and collection chamber 10106.
- Tube 10202 is in fluid communication with collection chamber 10106 wherein its contents are outputted to pump 10150 and production chamber 10102.
- FIG. 10B illustrates a side view of the portable hydrogen peroxide production unit 10000.
- unit 10000 can further include a plurality of wheels or casters 10300 for mobility.
- unit 10000 can also include a handle 10130 for additional portability and mobility.
- housing 10100 can further include access and closure part 10106A for accessing chamber 10106, access and closure part 10102A for accessing production chamber 10102, and access and closure part 10108A for accessing reservoir 10108.
- any of parts 10102A, 10106A, and 10108A may be any hinge operated, pivoting, locking, or sliding access lid, cover, closure, or seal.
- any of the aforementioned production systems and methods with respect to FIGS. 1A-10B may be as part of a small to medium or medium to large- scale production plant.
- the productions systems of FIGS. 1A-10B may also be a portable or mobile hydrogen production system that can have individual modular components or be a part of one single unit.
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Abstract
L'invention concerne une méthode, un système et un appareil de production de peroxyde d'hydrogène pour produire de grands volumes de peroxyde d'hydrogène ayant des concentrations supérieures ou égales 80 % dans un cycle continu. Dans un aspect, la méthode peut comprendre le mélange d'une enzyme NQO1, d'un composé ou d'une molécule activée par NQO1, et d'un cofacteur NADH ou NADPH avec une solution aqueuse, la distribution de la solution aqueuse dans ou sur une membrane semi-perméable, la membrane semi-perméable comprenant en outre une barrière de poids moléculaire prédéfini. De plus, une réaction d'oxydoréduction de l'enzyme NQO1, du composé ou de la molécule activée par NQO1, et du cofacteur NADH ou NADPH dans la solution aqueuse produit du peroxyde d'hydrogène à un niveau de concentration. Ici, le peroxyde d'hydrogène produit est au-dessus de la barrière de poids moléculaire prédéfini de la membrane semi-perméable et diffuse à travers la membrane semi-perméable pour être extrait pour utilisation.
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US20130253046A1 (en) * | 2010-09-22 | 2013-09-26 | The Board Of Regents Of The University Of Texas System | Methods of treating cancer comprising targeting nqo1 |
US20160030457A1 (en) * | 2013-04-09 | 2016-02-04 | The Board Of Regents Of The University Of Texas System | Tumor-selective combination therapy |
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