WO2019147046A1 - Cassette for tissue examination - Google Patents

Cassette for tissue examination Download PDF

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Publication number
WO2019147046A1
WO2019147046A1 PCT/KR2019/001031 KR2019001031W WO2019147046A1 WO 2019147046 A1 WO2019147046 A1 WO 2019147046A1 KR 2019001031 W KR2019001031 W KR 2019001031W WO 2019147046 A1 WO2019147046 A1 WO 2019147046A1
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Prior art keywords
tissue
lid
cassette
lens
tissue specimen
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PCT/KR2019/001031
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French (fr)
Korean (ko)
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유영훈
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(의) 삼성의료재단
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Publication of WO2019147046A1 publication Critical patent/WO2019147046A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q

Definitions

  • An embodiment of the present invention relates to a cassette for tissue inspection.
  • Histological examination is performed to diagnose malignancy of the tumor, determine the range of the lesion, success of resection, and prognosis.
  • the most common method of studying tissue is to make a tissue sample that can be observed with an optical microscope.
  • a grossing process is performed in which the lesion of the tissue is checked and the lesion site is cut into a cassette and placed in a cassette.
  • the tissue specimen After grossing, the tissue specimen is immersed in a fixative such as formaldehyde and then embedded. At this time, the inspector should open the lid to confirm whether the tissue sample has been successfully put into the cassette or not. However, it often happens that the tissue protrudes out of the cassette when the force is applied to open the lid. If the tissue protrudes out of the cassette, there is a risk of loss first, and the orientation or upside and downside of the tissue may change in the course of putting the tissue back into the cassette. Since the direction of the tissue or the up and down directions are very important factors in the pathology results, the reliability of the biopsy is deteriorated when such an accident occurs.
  • a fixative such as formaldehyde
  • the tissue when the tissue is attached to the lid during the embedding process, there is a great risk of losing the tissue when the cassette contains a very small tissue having a size of about 0.1 cm.
  • the cassette contains a very small tissue having a size of about 0.1 cm.
  • a cassette for tissue examination includes: a body having at least one through-hole formed in a lower surface thereof and an upper portion thereof opened to contain a tissue sample; And a lid having a magnifying lens for covering the body and enlarging a tissue sample contained in the body.
  • the user can easily grasp the size of tissue sample within the cassette through the magnifying lens, the state of the tissue sample, and the like. Particularly, a user can effectively observe a tissue sample having a size as small as about 0.1 cm as an endoscopic tissue specimen. Accordingly, it is possible to prevent an accident that the user is unable to see the tissue specimen and is discarded together with the cassette for tissue inspection while the tissue specimen is attached to the lid or the body.
  • the scope of the present invention is not limited by these effects.
  • 1 to 3 are an exploded perspective view, a combined perspective view, and a sectional view, respectively, of a cassette for tissue inspection according to an embodiment of the present invention.
  • FIG. 4 is an exploded perspective view of a cassette for tissue inspection according to another embodiment.
  • 5 and 6 are an exploded perspective view and a sectional view, respectively, of a cassette for tissue examination according to still another embodiment.
  • FIG. 7 is a view schematically showing a state in which a plurality of cassettes for tissue inspection are stored in a storage container.
  • a cassette for tissue examination includes: a body having at least one through-hole formed in a lower surface thereof and an upper portion thereof opened to contain a tissue sample; And a lid having a magnifying lens for covering the body and enlarging a tissue sample contained in the body.
  • the magnifying lens may be a convex lens.
  • the lid may be transparent.
  • the body includes a tissue fixing part for fixing a tissue specimen through a wall protruding upward from the lower surface, wherein the enlarging lens is configured such that when the lid covers the body, It can be placed at the overlapping position.
  • the tissue anchoring portion may have a scale on the underside.
  • the magnifying lens may be a Fresnel lens.
  • the thickness of the Fresnel lens may be less than or equal to the thickness of the lid edge.
  • 1 to 3 are an exploded perspective view, a combined perspective view, and a cross-sectional view, respectively, of a cassette for tissue inspection 100 according to an embodiment of the present invention.
  • the cassette 100 for tissue examination includes a body 110 and a lid 120.
  • the body 110 may have a box shape in which a tissue sample (TS) is contained therein and an open top portion.
  • the body 110 may include plastic, stainless steel, or the like which is not corroded by chemical substances such as formalin used in a tissue inspection process.
  • At least one through hole 110H may be formed in the lower surface of the body 110. [ The through hole 110H may provide a space through which the paraffin used in the embedding process passes.
  • One side surface of the body 110 may be inclined for labeling.
  • the lid 120 may cover the upper portion of the body 110.
  • the lid 120 may be provided with a latching portion for engaging with the body 110 and a latching portion for allowing the user U to easily close the lid 120 on the other side of the lid 120.
  • the present invention is not limited thereto .
  • the lid 120 has a magnifying lens 122 for enlarging and viewing a tissue sample TS contained in the body 110.
  • the focal length F of the magnifying lens 122 may be greater than the thickness h 110 of the body 110.
  • the focal length F of the magnifying lens 122 is larger than the thickness h 110 of the body 110, the distance between the tissue specimen TS located inside the body 110 and the magnifying lens 122 is always the magnifying lens 122 is smaller than the focal length F of the lens.
  • the user (U) can observe the phase (I TS) visible at the bottom of the tissue sample (TS) on the basis of Fig.
  • the amount of (I TS) of the tissue sample (TS) seen through the magnifying lens 122 may be larger than the actual size of the tissue sample (TS).
  • the magnification of the magnifying lens 122 may be 1.5 to 20 times, but the present invention is not limited thereto.
  • the user U can easily grasp whether or not a tissue sample TS having a small size exists inside the cassette, the state of the tissue sample TS, and the like.
  • the user U can effectively observe a tissue specimen (TS) having a size as small as about 0.1 cm, such as an endoscopic tissue specimen (TS). Accordingly, when the user U does not see the tissue specimen TS having a small size, the specimen TS is discarded together with the cassette 100 for tissue inspection in the state that the specimen TS is attached to the lid 120 or the body 110 Can be prevented.
  • TS tissue specimen
  • TS endoscopic tissue specimen
  • the magnifying lens 122 may be a convex lens 122C.
  • the convex lens 122C is a flat convex lens having a flat bottom surface.
  • the convex lens 122C may have a convex shape.
  • the magnifying lens 122 may be formed of a transparent material.
  • the magnifying lens 122 may be made of polyvinyl chloride (PVC), allyldiglycol carbon (CR-39), polymethylmethacrylate (PMMA), polycarbonate (PC) (Polystyrene, PS), but the present invention is not limited thereto.
  • the lid 120 may be transparent. That is, both the magnifying lens 122 and the peripheral portion 124 included in the lid 120 can be transparent.
  • the magnifying lens 122 and the peripheral portion 124 of the lid 120 may be integrally formed.
  • the user U can grasp the status or position of the tissue sample TS without opening the lid 120. [ Accordingly, it is possible to prevent an accident that the tissue specimen TS jumps out of the body 110 due to the mistake of the user U when the lid 120 is opened to confirm the tissue specimen TS.
  • FIG. 4 is an exploded perspective view of a tissue inspection cassette 400 according to another embodiment.
  • the body may include a tissue fixation portion 412 that adjusts the tissue sample TS through the upwardly projecting wall at the lower surface of the body 410.
  • a tissue fixing portion 412 including a wall may be disposed in the center of the body.
  • the walls can separate the interior and exterior spaces.
  • the user U can place a tissue sample TS to be fixed inside the wall.
  • the tissue sample TS can be fixed in the inner space of the tissue fixing part 412.
  • a through hole may be formed on the lower surface of the tissue fixing part 412, and the through hole formed inside the tissue fixing part 412 may be smaller than the through hole formed on the outside.
  • the enlarged lens 422 may be disposed at a position overlapping the tissue fixing portion 412 with the lid 420 covered with the body 410. That is, when the lid 420 covers the body 410, the user U can magnify and view the tissue specimen TS located inside the tissue fixation part 412 through the magnifying lens 422.
  • the tissue fixation portion 412 may have a scale 414 on its underside.
  • the user 41 can easily see the scale 414 even if the interval of the scale 414 is small since the scale 414 is enlarged through the magnifying lens 122.
  • the user U can easily and quickly grasp the size of the tissue specimen TS.
  • the scale 414 is depicted only on one corner of the tissue fixation part 412, but the present invention is not limited thereto.
  • the intervals of the graduations may be 1 mm, but the present invention is not limited thereto.
  • Fig. 5 and 6 are an exploded perspective view and a cross-sectional view, respectively, of a cassette for tissue inspection 500 according to another embodiment
  • Fig. 7 is a schematic view showing a state in which a plurality of cassettes for tissue inspection 500 are stored in a storage container C .
  • the magnifying lens 522 may be a Fresnel lens 522F.
  • a Fresnel lens 522F having a convex groove appears.
  • the grooves may be formed in concentric circles.
  • the Fresnel lens 522F can refract light through the groove to enlarge the size of the image. Therefore, the thickness of the enlarged lens 522 can be reduced while enlarging the tissue specimen TS.
  • the intervals of the grooves are exaggerated, but the intervals of the grooves may be 1 mm or less.
  • the Fresnel lens 522F is disposed in the lid 520.
  • the present invention is not limited thereto.
  • the entire upper surface of the lid 520 may have a groove, and the entire lid 520 may function as a single lens.
  • the thickness h - c of the Fresnel lens 522F may be less than the thickness h - p of the edge of the lid 520.
  • the thickness h - c of the Fresnel lens 522F can be defined as the largest value among the thicknesses at all points of the Fresnel lens 522F.
  • Figure 6 illustrates that the Fresnel lens (522F) of the maximum thickness (h- c) at the midpoint but the invention is not limited to this.
  • the thickness of the Fresnel lens 522F may be 5 mm or less.
  • the histological examination cassette 500 is superimposed as shown in Fig. Can be stored.
  • the edge of the lid 520 protrudes more upward than the Fresnel lens 522F with reference to FIG. 6, the groove of the Fresnel lens 522F abuts against the other tissue inspection cassette 500 . In this case, it is possible to prevent the grooves from being worn or damaged when the cassette 500 for tissue inspection is carried and stored.
  • a cassette for histological examination used in the field of pathology diagnosis.
  • the embodiments of the present invention can be applied to a sample storage device used in industry.

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Abstract

A cassette for tissue examination according to one embodiment of the present invention, comprises: at least one through hole formed in the lower surface thereof; a body having an open top, and capable of holding a tissue specimen; and a lid capable of covering the body, and having a magnifying lens which allows the tissue specimen contained in the body to be enlarged and viewed. Through the magnifying lens, a user can easily recognize whether a small sized tissue specimen is inside the cassette, the state of the tissue specimen, etc. In particular, the user can effectively observe a tissue specimen having a size as small as about 0.1 cm, such as an endoscopic tissue specimen. Accordingly, it is possible to prevent an accident in which the user is unable to see the tissue specimen and the tissue specimen is discarded with the cassette for tissue examination being attached to the lid or body.

Description

조직 검사용 카세트Cassette for tissue examination
본 발명의 실시예는 조직 검사용 카세트에 관한 것이다.An embodiment of the present invention relates to a cassette for tissue inspection.
조직 검사(histological examination)는 종양의 악성도 판정, 병변의 범위 확정, 절제의 성공 여부 및 예후 판정 등 병의 치료, 진단을 위해 수행된다. 조직을 연구하는 데 가장 흔히 쓰는 방법은 광학현미경으로 관찰할 수 있는 조직 표본(tissue sample)을 만드는 것이다. Histological examination is performed to diagnose malignancy of the tumor, determine the range of the lesion, success of resection, and prognosis. The most common method of studying tissue is to make a tissue sample that can be observed with an optical microscope.
조직 표본을 만들 때는, 우선 조직의 병변을 확인하고 병변 부위를 카세트 크기에 맞게 잘라서 카세트(cassette) 안에 넣는 육안 검사(grossing) 과정이 수행된다. When making a tissue specimen, first a grossing process is performed in which the lesion of the tissue is checked and the lesion site is cut into a cassette and placed in a cassette.
육안 검사(grossing) 수행 후에는 조직 표본을 포름알데히드(formaldyhyde)와 같은 고정액에 담가 고정한 후 포매(embedding)하는 등의 과정을 거치게 된다. 이때 조직 표본을 카세트에 넣는 작업을 잘 했는지, 조직이 빠져나가진 않았는지 등을 확인하기 위해서는 검사자가 뚜껑을 열어 확인하여야 한다. 그런데 이때 뚜껑을 열기 위해 힘을 줄 때 조직이 카세트 바깥으로 튀어나가는 일이 자주 발생한다. 조직이 카세트 바깥으로 튀어나가게 되면, 우선 분실의 위험이 있으며, 조직을 다시 카세트에 넣는 과정에서 조직의 방향 또는 위아래가 바뀔 수 있다. 조직의 방향 또는 위아래는 병리 결과에서 굉장히 중요한 요소이므로, 이와 같은 사고가 발생하는 경우 조직 검사의 신뢰성이 떨어지게 된다.After grossing, the tissue specimen is immersed in a fixative such as formaldehyde and then embedded. At this time, the inspector should open the lid to confirm whether the tissue sample has been successfully put into the cassette or not. However, it often happens that the tissue protrudes out of the cassette when the force is applied to open the lid. If the tissue protrudes out of the cassette, there is a risk of loss first, and the orientation or upside and downside of the tissue may change in the course of putting the tissue back into the cassette. Since the direction of the tissue or the up and down directions are very important factors in the pathology results, the reliability of the biopsy is deteriorated when such an accident occurs.
한편, 포매 과정에서 조직이 뚜껑에 붙게 되는 경우가 있는데, 크기가 01.cm 정도로 매우 작은 조직이 카세트에 들어있는 경우 조직을 분실할 위험이 매우 크다. 예를 들어 4개의 작은 조직 중 한 개가 뚜껑에 붙어 있어서 포매 작업을 수행하는 검사자가 이를 발견하지 못하는 경우 3개 조직만 포매되고 나머지 한 개는 일회용 뚜껑과 함께 버려질 수 있다. On the other hand, when the tissue is attached to the lid during the embedding process, there is a great risk of losing the tissue when the cassette contains a very small tissue having a size of about 0.1 cm. For example, if one of the four small tissues is attached to the lid and the examiner performing the forcing does not find it, only three tissues may be embedded and the other one discarded with the disposable lid.
본 발명의 일 실시예에 따른 조직 검사용 카세트는, 아랫면에 하나 이상의 통공이 형성되고, 상부가 개방되어 조직 표본을 담을 수 있는 몸체; 및 상기 몸체를 덮을 수 있고, 상기 몸체에 담긴 조직 표본을 확대해서 볼 수 있게 하는 확대 렌즈를 가지는 뚜껑;을 포함한다. A cassette for tissue examination according to an embodiment of the present invention includes: a body having at least one through-hole formed in a lower surface thereof and an upper portion thereof opened to contain a tissue sample; And a lid having a magnifying lens for covering the body and enlarging a tissue sample contained in the body.
본 발명의 일 실시예에 따른 조직 검사용 카세트에 의하면, 확대 렌즈를 통해 사용자는 크기가 작은 조직 표본이 카세트 내부에 들어 있는지, 조직 표본의 상태는 어떤지 등을 쉽게 파악할 수 있다. 특히, 사용자는 내시경 조직 표본과 같이 크기가 약 0.1cm 정도로 작은 조직 표본을 효과적으로 관찰할 수 있다. 이에 따라, 사용자가 조직 표본을 보지 못해 조직 표본이 뚜껑 또는 몸체에 붙은 상태에서 조직 검사용 카세트와 함께 버려지는 사고를 방지할 수 있다. 물론 이러한 효과에 의해 본 발명의 범위가 한정되는 것은 아니다.According to the cassette for histological examination according to an embodiment of the present invention, the user can easily grasp the size of tissue sample within the cassette through the magnifying lens, the state of the tissue sample, and the like. Particularly, a user can effectively observe a tissue sample having a size as small as about 0.1 cm as an endoscopic tissue specimen. Accordingly, it is possible to prevent an accident that the user is unable to see the tissue specimen and is discarded together with the cassette for tissue inspection while the tissue specimen is attached to the lid or the body. Of course, the scope of the present invention is not limited by these effects.
도 1 내지 도 3은 각각 본 발명의 일 실시예에 따른 조직 검사용 카세트의 분해 사시도, 결합 사시도, 단면도이다. 1 to 3 are an exploded perspective view, a combined perspective view, and a sectional view, respectively, of a cassette for tissue inspection according to an embodiment of the present invention.
도 4는 다른 실시예에 따른 조직 검사용 카세트의 분해 사시도이다. 4 is an exploded perspective view of a cassette for tissue inspection according to another embodiment.
도 5 및 도 6은 각각 또 다른 실시예에 따른 조직 검사용 카세트의 분해 사시도와 단면도이다.5 and 6 are an exploded perspective view and a sectional view, respectively, of a cassette for tissue examination according to still another embodiment.
도 7은 복수 개의 조직 검사용 카세트가 보관통에 보관된 상태를 개략적으로 표현한 그림이다.7 is a view schematically showing a state in which a plurality of cassettes for tissue inspection are stored in a storage container.
본 발명의 일 실시예에 따른 조직 검사용 카세트는, 아랫면에 하나 이상의 통공이 형성되고, 상부가 개방되어 조직 표본을 담을 수 있는 몸체; 및 상기 몸체를 덮을 수 있고, 상기 몸체에 담긴 조직 표본을 확대해서 볼 수 있게 하는 확대 렌즈를 가지는 뚜껑;을 포함한다. A cassette for tissue examination according to an embodiment of the present invention includes: a body having at least one through-hole formed in a lower surface thereof and an upper portion thereof opened to contain a tissue sample; And a lid having a magnifying lens for covering the body and enlarging a tissue sample contained in the body.
일 실시예에 따르면, 상기 확대 렌즈는 볼록 렌즈일 수 있다. According to one embodiment, the magnifying lens may be a convex lens.
일 실시예에 따르면, 상기 뚜껑은 투명할 수 있다. According to one embodiment, the lid may be transparent.
일 실시예에 따르면, 상기 몸체는, 상기 아랫면에서 위쪽을 향해 돌출된 벽을 통해 조직 표본을 고정하는 조직 고정부를 포함하고, 상기 확대 렌즈는 상기 뚜껑이 상기 몸체를 덮을 때 상기 조직 고정부와 중첩되는 곳에 배치될 수 있다. According to one embodiment, the body includes a tissue fixing part for fixing a tissue specimen through a wall protruding upward from the lower surface, wherein the enlarging lens is configured such that when the lid covers the body, It can be placed at the overlapping position.
일 실시예에 따르면, 상기 조직 고정부는 아랫면에 눈금을 가질 수 있다. According to one embodiment, the tissue anchoring portion may have a scale on the underside.
일 실시예에 따르면, 상기 확대 렌즈는 프레넬(Fresnel) 렌즈일 수 있다. According to one embodiment, the magnifying lens may be a Fresnel lens.
일 실시예에 따르면, 상기 프레넬 렌즈의 두께는 상기 뚜껑 가장자리의 두께 이하일 수 있다. According to one embodiment, the thickness of the Fresnel lens may be less than or equal to the thickness of the lid edge.
전술한 것 외의 다른 측면, 특징, 이점이 이하의 도면, 특허청구범위 및 발명의 상세한 설명으로부터 명확해질 것이다. Other aspects, features, and advantages will become apparent from the following drawings, claims, and detailed description of the invention.
본 발명은 다양한 변환을 가할 수 있고 여러 가지 실시예를 가질 수 있는바, 특정 실시예들을 도면에 예시하고 상세한 설명에 설명하고자 한다. 본 발명의 효과 및 특징, 그리고 그것들을 달성하는 방법은 도면과 함께 상세하게 후술되어 있는 실시예들을 참조하면 명확해질 것이다. 그러나 본 발명은 이하에서 개시되는 실시예들에 한정되는 것이 아니라 다양한 형태로 구현될 수 있다.The present invention is capable of various modifications and various embodiments, and specific embodiments are illustrated in the drawings and described in the detailed description. The effects and features of the present invention and methods of achieving them will be apparent with reference to the embodiments described in detail below with reference to the drawings. However, the present invention is not limited to the embodiments described below, but may be implemented in various forms.
이하의 실시예에서, 제1, 제2 등의 용어는 한정적인 의미가 아니라 하나의 구성 요소를 다른 구성 요소와 구별하는 목적으로 사용된다.In the following embodiments, the terms first, second, etc. are used for the purpose of distinguishing one element from another element, rather than limiting.
이하의 실시예에서, 단수의 표현은 문맥상 명백하게 다르게 뜻하지 않는 한, 복수의 표현을 포함한다.In the following examples, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise.
이하의 실시예에서, 포함하다 또는 가지다 등의 용어는 명세서상에 기재된 특징, 또는 구성요소가 존재함을 의미하는 것이고, 하나 이상의 다른 특징들 또는 구성요소가 부가될 가능성을 미리 배제하는 것은 아니다.In the following embodiments, terms such as inclusive or possessive are intended to mean that a feature, or element, described in the specification is present, and does not preclude the possibility that one or more other features or elements may be added.
이하의 실시예에서, 막, 영역, 구성 요소 등의 부분이 다른 부분 '위'에 또는 '상'에 있다고 할 때, 다른 부분의 바로 위에 있는 경우뿐만 아니라, 그 중간에 다른 막, 영역, 구성 요소 등이 개재되어 있는 경우도 포함한다.In the following embodiments, when a portion of a film, an area, a component or the like is referred to as being "above" or "above" another portion, Elements and the like are interposed.
도면에서는 설명의 편의를 위하여 구성 요소들이 그 크기가 과장 또는 축소될 수 있다. 예컨대, 도면에서 나타난 각 구성의 크기 및 두께는 설명의 편의를 위해 임의로 나타내었으므로, 본 발명이 반드시 도시된 바에 한정되지 않는다.In the drawings, components may be exaggerated or reduced in size for convenience of explanation. For example, the size and thickness of each component shown in the drawings are arbitrarily shown for convenience of explanation, and thus the present invention is not necessarily limited to those shown in the drawings.
도 1 내지 도 3은 각각 본 발명의 일 실시예에 따른 조직 검사용 카세트(100)의 분해 사시도, 결합 사시도, 단면도이다. 1 to 3 are an exploded perspective view, a combined perspective view, and a cross-sectional view, respectively, of a cassette for tissue inspection 100 according to an embodiment of the present invention.
본 발명의 일 실시예에 따른 조직 검사용 카세트(100)는 몸체(110) 및 뚜껑(120)을 포함한다. 도 1 내지 도 3을 참조하면, 몸체(110)는 내부에 조직 표본(TS)을 담는 곳으로, 상부가 개방된 상자 형태를 가질 수 있다. 몸체(110)는 조직 검사 과정에서 사용되는 포르말린(formalin) 등의 화학 물질에 부식되지 않는 플라스틱, 스테인리스 등을 포함할 수 있다. 몸체(110)의 아랫면에는 하나 이상의 통공(110H)이 형성될 수 있다. 통공(110H)은 포매(embedding) 과정에서 사용되는 파라핀(paraffin)이 통과하는 공간을 제공할 수 있다. 몸체(110)의 한쪽 옆면은 라벨링(labeling)을 하기 위해 기울어져 있을 수 있다. The cassette 100 for tissue examination according to an embodiment of the present invention includes a body 110 and a lid 120. Referring to FIGS. 1 to 3, the body 110 may have a box shape in which a tissue sample (TS) is contained therein and an open top portion. The body 110 may include plastic, stainless steel, or the like which is not corroded by chemical substances such as formalin used in a tissue inspection process. At least one through hole 110H may be formed in the lower surface of the body 110. [ The through hole 110H may provide a space through which the paraffin used in the embedding process passes. One side surface of the body 110 may be inclined for labeling.
뚜껑(120)은 몸체(110)의 상부를 덮을 수 있다. 뚜껑(120)의 일측에는 몸체(110)와 결합하기 위한 걸림부가, 다른 일측에는 사용자(U)가 뚜껑(120)을 쉽게 여닫게 하기 위한 손잡이부가 배치될 수 있는데 본 발명이 이에 제한되는 것은 아니다. The lid 120 may cover the upper portion of the body 110. The lid 120 may be provided with a latching portion for engaging with the body 110 and a latching portion for allowing the user U to easily close the lid 120 on the other side of the lid 120. However, the present invention is not limited thereto .
뚜껑(120)은 몸체(110)에 담긴 조직 표본(TS)을 확대해서 볼 수 있게 하는 확대 렌즈(122)를 가진다. 확대 렌즈(122)의 초점 거리(F)는 몸체(110)의 두께(h110)보다 클 수 있다. 확대 렌즈(122)의 초점 거리(F)가 몸체(110)의 두께(h110)보다 큰 경우, 몸체(110) 내부에 위치한 조직 표본(TS)과 확대 렌즈(122)와의 거리는 항상 확대 렌즈(122)의 초점 거리(F)보다 작게 된다. 이 경우, 사용자(U)는 도 3을 기준으로 조직 표본(TS)의 아래쪽에 보이는 상(ITS)을 관찰할 수 있다. The lid 120 has a magnifying lens 122 for enlarging and viewing a tissue sample TS contained in the body 110. The focal length F of the magnifying lens 122 may be greater than the thickness h 110 of the body 110. When the focal length F of the magnifying lens 122 is larger than the thickness h 110 of the body 110, the distance between the tissue specimen TS located inside the body 110 and the magnifying lens 122 is always the magnifying lens 122 is smaller than the focal length F of the lens. In this case, the user (U) can observe the phase (I TS) visible at the bottom of the tissue sample (TS) on the basis of Fig.
확대 렌즈(122)를 통해 보이는 조직 표본(TS)의 상(ITS)의 크기는 조직 표본(TS)의 실제 크기보다 클 수 있다. 확대 렌즈(122)의 배율은 1.5배 내지 20배 등일 수 있으나 본 발명이 이에 제한되는 것은 아니다.The amount of (I TS) of the tissue sample (TS) seen through the magnifying lens 122 may be larger than the actual size of the tissue sample (TS). The magnification of the magnifying lens 122 may be 1.5 to 20 times, but the present invention is not limited thereto.
확대 렌즈(122)를 통해, 사용자(U)는 크기가 작은 조직 표본(TS)이 카세트 내부에 들어 있는지, 조직 표본(TS)의 상태는 어떤지 등을 쉽게 파악할 수 있다. 특히, 사용자(U)는 내시경 조직 표본(TS)과 같이 크기가 약 0.1cm 정도로 작은 조직 표본(TS)을 효과적으로 관찰할 수 있다. 이에 따라, 사용자(U)가 크기가 작은 조직 표본(TS)을 보지 못해 조직 표본(TS)이 뚜껑(120) 또는 몸체(110)에 붙은 상태에서 조직 검사용 카세트(100)와 함께 버려지는 사고를 방지할 수 있다. Through the magnifying lens 122, the user U can easily grasp whether or not a tissue sample TS having a small size exists inside the cassette, the state of the tissue sample TS, and the like. In particular, the user U can effectively observe a tissue specimen (TS) having a size as small as about 0.1 cm, such as an endoscopic tissue specimen (TS). Accordingly, when the user U does not see the tissue specimen TS having a small size, the specimen TS is discarded together with the cassette 100 for tissue inspection in the state that the specimen TS is attached to the lid 120 or the body 110 Can be prevented.
일 실시예에 따르면, 확대 렌즈(122)는 볼록 렌즈(122C)일 수 있다. 도 3에서는 볼록 렌즈(122C)가 아랫면이 평평한 평볼록 렌즈 형태인 것을 예시하였으나 본 발명이 이에 제한되는 것은 아니며, 볼록 렌즈(122C)는 윗면과 아랫면이 모두 볼록한 형태를 가질 수도 있다.According to one embodiment, the magnifying lens 122 may be a convex lens 122C. In FIG. 3, the convex lens 122C is a flat convex lens having a flat bottom surface. However, the present invention is not limited thereto. The convex lens 122C may have a convex shape.
확대 렌즈(122)는 투명한 재질로 형성될 수 있다. 예컨대 확대 렌즈(122)는 폴리염화비닐(PVC, Polyvinyl chloride), 아릴디글리콜카보네이트(Allyldiglycol Carbonate, CR-39), 폴리메틸메타크릴레이트(PMMA, Polymethylmethacrylate), 폴리카보네이트(Polycarbonate, PC), 폴리스티렌(Polystylene,PS) 등의 투명한 플라스틱을 포함할 수 있으나 본 발명이 이에 제한되는 것은 아니다. The magnifying lens 122 may be formed of a transparent material. For example, the magnifying lens 122 may be made of polyvinyl chloride (PVC), allyldiglycol carbon (CR-39), polymethylmethacrylate (PMMA), polycarbonate (PC) (Polystyrene, PS), but the present invention is not limited thereto.
한편, 일 실시예에 따르면 뚜껑(120)은 투명할 수 있다. 즉, 뚜껑(120)에 포함되는 확대 렌즈(122)와 주변부(124)는 모두 투명할 수 있다. 뚜껑(120)의 확대 렌즈(122)와 주변부(124)는 일체로 형성될 수 있다. 뚜껑(120) 전체가 투명한 경우, 사용자(U)는 뚜껑(120)을 열지 않고도 조직 표본(TS)의 상태나 위치를 파악할 수 있다. 이에 따라, 조직 표본(TS)을 확인하기 위해 뚜껑(120)을 열 때 사용자(U)의 실수에 의해 조직 표본(TS)이 몸체(110) 바깥으로 튀어나와 분실되는 사고를 방지할 수 있다. Meanwhile, according to one embodiment, the lid 120 may be transparent. That is, both the magnifying lens 122 and the peripheral portion 124 included in the lid 120 can be transparent. The magnifying lens 122 and the peripheral portion 124 of the lid 120 may be integrally formed. When the entire lid 120 is transparent, the user U can grasp the status or position of the tissue sample TS without opening the lid 120. [ Accordingly, it is possible to prevent an accident that the tissue specimen TS jumps out of the body 110 due to the mistake of the user U when the lid 120 is opened to confirm the tissue specimen TS.
도 4는 다른 실시예에 따른 조직 검사용 카세트(400)의 분해 사시도이다. 4 is an exploded perspective view of a tissue inspection cassette 400 according to another embodiment.
일 실시예에 따르면, 본체는 몸체(410)의 아랫면에서 위쪽을 향해 돌출된 벽을 통해 조직 표본(TS)을 조정하는 조직 고정부(412)를 포함할 수 있다. According to one embodiment, the body may include a tissue fixation portion 412 that adjusts the tissue sample TS through the upwardly projecting wall at the lower surface of the body 410.
도 4를 참조하면, 본체의 가운데에는 벽을 포함하는 조직 고정부(412)가 배치될 수 있다. 벽은 내부, 외부 공간을 분리할 수 있다. 사용자(U)는 고정되어야 할 조직 표본(TS)을 벽의 내부에 위치시킬 수 있다. 뚜껑(120)이 덮인 상태에서, 조직 표본(TS)은 조직 고정부(412)의 내부 공간에 위치가 고정될 수 있다. 이때 조직 고정부(412)의 아랫면에도 통공이 형성될 수 있는데, 조직 고정부(412) 내부에 형성된 통공은 외부에 형성된 통공보다 크기가 작을 수 있다. Referring to FIG. 4, a tissue fixing portion 412 including a wall may be disposed in the center of the body. The walls can separate the interior and exterior spaces. The user U can place a tissue sample TS to be fixed inside the wall. In the state that the lid 120 is covered, the tissue sample TS can be fixed in the inner space of the tissue fixing part 412. At this time, a through hole may be formed on the lower surface of the tissue fixing part 412, and the through hole formed inside the tissue fixing part 412 may be smaller than the through hole formed on the outside.
일 실시예에 따르면, 뚜껑(420)이 몸체(410)를 덮은 상태에서 확대 렌즈(422)는 조직 고정부(412)와 중첩되는 곳에 배치될 수 있다. 즉 뚜껑(420)이 몸체(410)를 덮을 때, 사용자(U)는 확대 렌즈(422)를 통해 조직 고정부(412)의 내부에 위치한 조직 표본(TS)을 확대하여 볼 수 있다. According to one embodiment, the enlarged lens 422 may be disposed at a position overlapping the tissue fixing portion 412 with the lid 420 covered with the body 410. That is, when the lid 420 covers the body 410, the user U can magnify and view the tissue specimen TS located inside the tissue fixation part 412 through the magnifying lens 422. [
일 실시예에 따르면, 조직 고정부(412)는 아랫면에 눈금(414)을 가질 수 있다. 확대 렌즈(122)를 통해 눈금(414) 역시 확대되어 보이므로, 눈금(414)의 간격이 작더라도 사용자(U)는 눈금(414)을 쉽게 볼 수 있다. 이에 따라, 사용자(U)는 조직 표본(TS)의 크기를 쉽고 빠르게 파악할 수 있다. 도 4에서는 눈금(414)이 조직 고정부(412)의 한쪽 모서리에만 그려진 것을 예시하였으나 본 발명이 이에 제한되는 것은 아니다. 한편, 눈금의 간격은 1mm일 수 있으나 본 발명이 이에 제한되는 것은 아니다.According to one embodiment, the tissue fixation portion 412 may have a scale 414 on its underside. The user 41 can easily see the scale 414 even if the interval of the scale 414 is small since the scale 414 is enlarged through the magnifying lens 122. [ Thus, the user U can easily and quickly grasp the size of the tissue specimen TS. In FIG. 4, the scale 414 is depicted only on one corner of the tissue fixation part 412, but the present invention is not limited thereto. On the other hand, the intervals of the graduations may be 1 mm, but the present invention is not limited thereto.
도 5 및 도 6은 각각 또 다른 실시예에 따른 조직 검사용 카세트(500)의 분해 사시도와 단면도이며, 도 7은 복수 개의 조직 검사용 카세트(500)가 보관통(C)에 보관된 상태를 개략적으로 표현한 그림이다.5 and 6 are an exploded perspective view and a cross-sectional view, respectively, of a cassette for tissue inspection 500 according to another embodiment, and Fig. 7 is a schematic view showing a state in which a plurality of cassettes for tissue inspection 500 are stored in a storage container C .
일 실시예에 따르면, 확대 렌즈(522)는 프레넬(Fresnel) 렌즈(522F)일 수 있다. 도 5 및 도 6을 참조하면, 볼록한 그루브(groove)를 가지는 프레넬 렌즈(522F)가 나타난다. 그루브는 동심원 형태로 형성될 수 있다. 프레넬 렌즈(522F)는 그루브를 통해 빛을 굴절시켜, 상의 크기를 확대할 수 있다. 따라서, 조직 표본(TS)을 확대해서 볼 수 있으면서도 확대 렌즈(522)의 두께를 줄일 수 있다. 도 5 및 도 6에서는 그루브의 간격을 과장하여 표현하였으나, 그루브의 간격은 1mm 이하일 수 있다. According to one embodiment, the magnifying lens 522 may be a Fresnel lens 522F. Referring to Figs. 5 and 6, a Fresnel lens 522F having a convex groove appears. The grooves may be formed in concentric circles. The Fresnel lens 522F can refract light through the groove to enlarge the size of the image. Therefore, the thickness of the enlarged lens 522 can be reduced while enlarging the tissue specimen TS. In FIGS. 5 and 6, the intervals of the grooves are exaggerated, but the intervals of the grooves may be 1 mm or less.
도 5에서는 프레넬 렌즈(522F)가 뚜껑(520) 가운데 배치된 것을 예시하였으나, 본 발명이 이에 제한되는 것은 아니다. 예컨대, 뚜껑(520)의 상면 전체가 그루브를 가져, 뚜껑(520) 전체가 하나의 렌즈로 기능할 수도 있다. In FIG. 5, the Fresnel lens 522F is disposed in the lid 520. However, the present invention is not limited thereto. For example, the entire upper surface of the lid 520 may have a groove, and the entire lid 520 may function as a single lens.
일 실시예에 따르면, 프레넬 렌즈(522F)의 두께(h-c)는 뚜껑(520) 가장자리의 두께(h-p) 이하일 수 있다. 프레넬 렌즈(522F)의 두께(h-c)는, 프레넬 렌즈(522F)의 모든 지점에서의 두께 중 가장 큰 값으로 정의될 수 있다. 도 6에서는 프레넬 렌즈(522F) 가운데 지점에서 두께(h-c)가 최대인 것을 예시하였으나 본 발명이 이에 제한되는 것은 아니다. 프레넬 렌즈(522F)의 두께는 5mm 이하일 수 있다. According to one embodiment, the thickness h - c of the Fresnel lens 522F may be less than the thickness h - p of the edge of the lid 520. The thickness h - c of the Fresnel lens 522F can be defined as the largest value among the thicknesses at all points of the Fresnel lens 522F. Although Figure 6 illustrates that the Fresnel lens (522F) of the maximum thickness (h- c) at the midpoint but the invention is not limited to this. The thickness of the Fresnel lens 522F may be 5 mm or less.
프레넬 렌즈(522F)의 두께(h-c)가 뚜껑(520) 가장자리의 두께(h-p) 이하인 경우, 조직 검사용 카세트(500)는 도 7과 같이 포개어져 별도의 보관통(C)에 보관될 수 있다. 이때 뚜껑(520)의 가장자리가 프레넬 렌즈(522F)보다 도 6을 기준으로 더 위쪽으로 튀어나와 있으므로, 프레넬 렌즈(522F)의 그루브(groove)는 다른 조직 검사용 카세트(500)와 맞닿지 않을 수 있다. 이 경우, 조직 검사용 카세트(500)를 운반, 보관할 때 그루브(groove)가 마모 또는 손상되는 것을 방지할 수 있다.When the thickness h- c of the Fresnel lens 522F is not more than the thickness h- p of the edge of the lid 520, the histological examination cassette 500 is superimposed as shown in Fig. Can be stored. At this time, since the edge of the lid 520 protrudes more upward than the Fresnel lens 522F with reference to FIG. 6, the groove of the Fresnel lens 522F abuts against the other tissue inspection cassette 500 . In this case, it is possible to prevent the grooves from being worn or damaged when the cassette 500 for tissue inspection is carried and stored.
본 발명은 도면에 도시된 실시예를 참고로 설명되었으나 이는 예시적인 것에 불과하며, 당해 기술 분야에서 통상의 지식을 가진 자라면 이로부터 다양한 변형 및 균등한 다른 실시예가 가능하다는 점을 이해할 것이다. 따라서, 본 발명의 진정한 기술적 보호 범위는 첨부된 특허청구범위의 기술적 사상에 의하여 정해져야 할 것이다.While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the invention. Accordingly, the true scope of the present invention should be determined by the technical idea of the appended claims.
본 발명의 일 실시예에 의하면, 병리 진단 분야에서 사용되는 조직 검사용 카세트를 제공한다. 또한, 산업상 이용하는 시료 보관 장치 등에 본 발명의 실시예들을 적용할 수 있다. According to an embodiment of the present invention, there is provided a cassette for histological examination used in the field of pathology diagnosis. In addition, the embodiments of the present invention can be applied to a sample storage device used in industry.

Claims (7)

  1. 아랫면에 하나 이상의 통공이 형성되고, 상부가 개방되어 조직 표본을 담을 수 있는 몸체; 및A body having at least one through-hole formed in a lower surface thereof and an upper portion thereof being openable to hold a tissue sample; And
    상기 몸체를 덮을 수 있고, 상기 몸체에 담긴 조직 표본을 확대해서 볼 수 있게 하는 확대 렌즈를 가지는 뚜껑;을 포함하는, 조직 검사용 카세트. And a lid having a magnifying lens capable of covering the body and enlarging a tissue sample contained in the body.
  2. 제1항에 있어서, The method according to claim 1,
    상기 확대 렌즈는 볼록 렌즈인, 조직 검사용 카세트. Wherein the magnifying lens is a convex lens.
  3. 제1항에 있어서,The method according to claim 1,
    상기 뚜껑은 투명한, 조직 검사용 카세트.The lid is transparent, a cassette for histological examination.
  4. 제1항에 있어서, The method according to claim 1,
    상기 몸체는, 상기 아랫면에서 위쪽을 향해 돌출된 벽을 통해 조직 표본을 고정하는 조직 고정부를 포함하고, Wherein the body includes a tissue fixing part for fixing a tissue sample through a wall protruding upward from the lower surface,
    상기 확대 렌즈는 상기 뚜껑이 상기 몸체를 덮을 때 상기 조직 고정부와 중첩되는 곳에 배치되는, 조직 검사용 카세트.Wherein the magnifying lens is disposed at a position overlapping the tissue fixing part when the lid covers the body.
  5. 제4항에 있어서, 5. The method of claim 4,
    상기 조직 고정부는 아랫면에 눈금을 가지는, 조직 검사용 카세트.And the tissue fixing section has a scale on the lower surface thereof.
  6. 제1항에 있어서, The method according to claim 1,
    상기 확대 렌즈는 프레넬(Fresnel) 렌즈인, 조직 검사용 카세트.Wherein the enlarged lens is a Fresnel lens.
  7. 제6항에 있어서, The method according to claim 6,
    상기 프레넬 렌즈의 두께는 상기 뚜껑의 가장자리의 두께 이하인, 조직 검사용 카세트.Wherein the thickness of the Fresnel lens is equal to or less than the thickness of the edge of the lid.
PCT/KR2019/001031 2018-01-26 2019-01-24 Cassette for tissue examination WO2019147046A1 (en)

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