WO2019140019A8 - Traitement acoustique pour thérapie cellulaire et génique - Google Patents

Traitement acoustique pour thérapie cellulaire et génique Download PDF

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Publication number
WO2019140019A8
WO2019140019A8 PCT/US2019/012950 US2019012950W WO2019140019A8 WO 2019140019 A8 WO2019140019 A8 WO 2019140019A8 US 2019012950 W US2019012950 W US 2019012950W WO 2019140019 A8 WO2019140019 A8 WO 2019140019A8
Authority
WO
WIPO (PCT)
Prior art keywords
cell
gene therapy
acoustic processing
closed
manufacturing process
Prior art date
Application number
PCT/US2019/012950
Other languages
English (en)
Other versions
WO2019140019A1 (fr
Inventor
Bart Lipkens
Rui TOSTOES
Jr. Walter M. Presz
Benjamin Ross-Johnsrud
Kedar CHITALE
Iii Thomas J. Kennedy
Brian DUTRA
Brian Mccarthy
Jack Saloio
Original Assignee
Flodesign Sonics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/916,270 external-priority patent/US11377651B2/en
Priority claimed from US15/942,427 external-priority patent/US11085035B2/en
Priority claimed from US15/942,316 external-priority patent/US11021699B2/en
Priority claimed from US15/963,809 external-priority patent/US11474085B2/en
Priority claimed from US15/983,823 external-priority patent/US11459540B2/en
Priority claimed from US16/010,296 external-priority patent/US20180362918A1/en
Priority claimed from US16/124,184 external-priority patent/US11214789B2/en
Application filed by Flodesign Sonics, Inc. filed Critical Flodesign Sonics, Inc.
Priority to EP19738317.7A priority Critical patent/EP3737738A4/fr
Priority to CN201980007864.7A priority patent/CN111630146A/zh
Publication of WO2019140019A1 publication Critical patent/WO2019140019A1/fr
Publication of WO2019140019A8 publication Critical patent/WO2019140019A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/28—Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/22—Settling tanks; Sedimentation by gravity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1807—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using counter-currents, e.g. fluidised beds

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un système fluidique fermé et modulaire composé d'un ou plusieurs éléments acoustiques et de réactifs de traitement de cellules. Le système utilise un procédé de fabrication cellulaire pour produire des agents thérapeutiques de thérapie cellulaire et génique.
PCT/US2019/012950 2018-01-09 2019-01-09 Traitement acoustique pour thérapie cellulaire et génique WO2019140019A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP19738317.7A EP3737738A4 (fr) 2018-01-09 2019-01-09 Traitement acoustique pour thérapie cellulaire et génique
CN201980007864.7A CN111630146A (zh) 2018-01-09 2019-01-09 用于细胞疗法和基因疗法的声学加工

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US201862615420P 2018-01-09 2018-01-09
US62/615,420 2018-01-09
US201862617074P 2018-01-12 2018-01-12
US62/617,074 2018-01-12
US15/916,270 US11377651B2 (en) 2016-10-19 2018-03-08 Cell therapy processes utilizing acoustophoresis
US15/916,270 2018-03-08
US15/942,427 US11085035B2 (en) 2016-05-03 2018-03-30 Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
US15/942,427 2018-03-30
US15/942,316 2018-03-30
US15/942,316 US11021699B2 (en) 2015-04-29 2018-03-30 Separation using angled acoustic waves
US15/963,809 US11474085B2 (en) 2015-07-28 2018-04-26 Expanded bed affinity selection
US15/963,809 2018-04-26
US201862668777P 2018-05-08 2018-05-08
US62/668,777 2018-05-08
US15/983,823 2018-05-18
US15/983,823 US11459540B2 (en) 2015-07-28 2018-05-18 Expanded bed affinity selection
US16/010,296 2018-06-15
US16/010,296 US20180362918A1 (en) 2016-05-03 2018-06-15 Cell Therapy Processes Utilizing Acoustophoresis
US16/124,184 2018-09-06
US16/124,184 US11214789B2 (en) 2016-05-03 2018-09-06 Concentration and washing of particles with acoustics

Publications (2)

Publication Number Publication Date
WO2019140019A1 WO2019140019A1 (fr) 2019-07-18
WO2019140019A8 true WO2019140019A8 (fr) 2020-08-27

Family

ID=67219903

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2019/012950 WO2019140019A1 (fr) 2018-01-09 2019-01-09 Traitement acoustique pour thérapie cellulaire et génique

Country Status (3)

Country Link
EP (1) EP3737738A4 (fr)
CN (1) CN111630146A (fr)
WO (1) WO2019140019A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US20230036073A1 (en) * 2020-01-17 2023-02-02 Flodesign Sonics, Inc. Enhanced acoustic particle processing with seeding particles
EP4144826A1 (fr) 2021-09-06 2023-03-08 Kolibri Système de culture cellulaire comprenant des compartiments et un dispositif d'actionnement acoustique et procédés associés

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007128795A2 (fr) * 2006-05-05 2007-11-15 Erysave Ab Procédé de séparation
WO2012081931A2 (fr) 2010-12-17 2012-06-21 Kim Sung-Chun Procédé et appareil utilisables en vue de la production de cellules et de matériaux solubles dans les graisses par culture de cellules
US9688958B2 (en) * 2012-03-15 2017-06-27 Flodesign Sonics, Inc. Acoustic bioreactor processes
US9745548B2 (en) * 2012-03-15 2017-08-29 Flodesign Sonics, Inc. Acoustic perfusion devices
US20150253226A1 (en) * 2012-09-21 2015-09-10 Acousort Ab Method for separating cells-bead complexes
DE102014005451A1 (de) 2014-04-07 2015-10-08 Adam Krecisz Saatgutgranulat und Verfahren sowie Vorrichtung zu dessen Herstellung
EP3288660A1 (fr) * 2015-04-29 2018-03-07 Flodesign Sonics Inc. Dispositif acoustophorétique pour déviation de particules à onde angulaire
US9663756B1 (en) * 2016-02-25 2017-05-30 Flodesign Sonics, Inc. Acoustic separation of cellular supporting materials from cultured cells

Also Published As

Publication number Publication date
EP3737738A4 (fr) 2021-05-05
CN111630146A (zh) 2020-09-04
EP3737738A1 (fr) 2020-11-18
WO2019140019A1 (fr) 2019-07-18

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