WO2019115194A1 - Dispositif de détermination de métabolites finis dans la peau - Google Patents

Dispositif de détermination de métabolites finis dans la peau Download PDF

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Publication number
WO2019115194A1
WO2019115194A1 PCT/EP2018/082149 EP2018082149W WO2019115194A1 WO 2019115194 A1 WO2019115194 A1 WO 2019115194A1 EP 2018082149 W EP2018082149 W EP 2018082149W WO 2019115194 A1 WO2019115194 A1 WO 2019115194A1
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WO
WIPO (PCT)
Prior art keywords
skin
unit
light
arrangement
treatment
Prior art date
Application number
PCT/EP2018/082149
Other languages
German (de)
English (en)
Inventor
Andreas Bock
Thomas Welss
Original Assignee
Henkel Ag & Co. Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henkel Ag & Co. Kgaa filed Critical Henkel Ag & Co. Kgaa
Publication of WO2019115194A1 publication Critical patent/WO2019115194A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/443—Evaluating skin constituents, e.g. elastin, melanin, water
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0204—Operational features of power management
    • A61B2560/0214—Operational features of power management of power generation or supply
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4842—Monitoring progression or stage of a disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/7405—Details of notification to user or communication with user or patient ; user input means using sound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/7475—User input or interface means, e.g. keyboard, pointing device, joystick

Definitions

  • the invention relates to an arrangement for determining skin properties and a
  • Computer program product which is designed to be executed on a portable computing unit.
  • an evaluation unit for evaluating the detected skin characteristics and for determining the skin properties based on the detected skin characteristics
  • User interface is designed to interact with a user
  • evaluation unit is executed:
  • evaluation unit is a portable computing unit
  • the detection unit is designed to emit light in a wavelength range between 200 nm and 420 nm in the direction of a skin surface to be examined and to emit light in a wavelength range between 200 nm and 1500 nm and to detect a proportion of the reflected light and a proportion of light emitted by autofluorescence light.
  • an arrangement for determining skin properties comprises: a detection unit for detecting skin features, a
  • the evaluation unit is designed to perform the following functions: a
  • the evaluation unit is a portable computing unit and the detection unit is designed to light in one
  • Wavelength range between 200 nm and 420 nm in the direction of a to be examined
  • first light in a first wavelength range or
  • the first wavelength range extends from 200 nm to 420 nm.
  • the thus illuminated skin will reflect a portion of the light in the first wavelength range; the reflected light is also from the first wavelength range.
  • the light will excite certain metabolic end products in the skin to autofluorescence, so that the skin emits light in a second wavelength range due to the autofluorescence, the second wavelength range being, for example, from 420 nm to 1500 nm.
  • the detection unit detects both the reflected light in the first wavelength range and that by autofluorescence in the second
  • Wavelength range emitted light Wavelength range emitted light.
  • autofluorescence is understood to be the ability of the skin to emit light without additional substances being introduced into the skin.
  • metabolic end products may be, for example, advanced
  • AGEs are metabolic end products that are formed by non-enzymatic reaction (Maillard reaction) of sugars with lipids, nucleic acids and especially proteins. They accumulate in the context of aging in tissues and contribute to a number of diseases, such as diabetes mellitus including typical complications, neurodegenerative diseases and inflammatory reactions. They also play a role in skin aging. Examples of AGEs are 3-deoxyglucosone (3-DG) and methylglyoxal (MGO). The formation of AGEs in tissues usually takes weeks or years and therefore also applies mainly to long-lived proteins, such as. Collagen. However, an increase in oxidative stress, smoking or other stressors may also lead to a more rapid formation of AGEs. Also a recording about the food is possible.
  • Maillard reaction non-enzymatic reaction
  • the device described herein makes it possible to determine the content of AGEs in the skin by determining the autofluorescence of the skin in a specific range of Spektra I. Accordingly, the ascertained skin property is a content of metabolic end products, in particular a content of AGEs.
  • a measuring device (the detection unit) based on the autofluorescence of the skin, which as a device to a portable, personal device such as a user
  • Smartphone tablet or other computer unit (these units can be generally referred to as a computing unit or portable computing unit) connected or integrated in it, cosmetically relevant parameters of the skin are measured, in particular the content of AGEs in the skin.
  • a computer program product e.g., software or personal / portable device software
  • the parameters (AGEs content) are then displayed in the form of values, arbitrary units, or verbal derivatives. From the parameters can then (a) derived product recommendations for individually fitting care products and individual treatment recommendations and / or (b) the treatment success in a cosmetic treatment, which has the goal of positively influencing the measured parameters, determined and / or spent.
  • a positive influence may include an improvement of the determined skin property or at least no deterioration of the identified skin property.
  • the measuring device may have an interface via which a connection with the
  • the arithmetic unit may have a first interface and a second interface.
  • the first interface can be designed as a counterpart to the interface of the measuring device, ie to connect the measuring device to the computing unit.
  • the second interface can be designed to connect the arithmetic unit to a data network. These connections are designed to transmit information in at least one direction, preferably in both directions.
  • the connection between the measuring device and the computing unit on the one hand and the connection between the computing unit and an access point of the data network can be wired or wireless. Wired connections can, for example, use optical or electrical signals for information transmission. Use wireless connections typically electromagnetic waves for signal transmission, eg radio signals or optical signals.
  • protocols can be used that work according to the principles of mesh networks.
  • the thread protocol which is based on IPv6 can be used for the data transmission and for the connection of the measuring device to the arithmetic unit.
  • the thread protocol is used in particular to connect automated or semi-automated devices with each other, in this case, for example, the detection unit with the arithmetic unit.
  • the measuring device can be structurally plugged onto the arithmetic unit in one example, or conversely the arithmetic unit to the measuring device.
  • This means that the measuring device is mechanically fastened to the arithmetic unit or to a housing of the arithmetic unit. For example, this can be done by a tool-free installation via a reversible connection.
  • the measuring device In the plugged position, the measuring device can be equipped with a releasable frictional or
  • the interfaces between the measuring device and the arithmetic unit can be arranged so that in the plugged position an electrical connection between the measuring device and the arithmetic unit is automatically established or established.
  • the arithmetic unit may be an application (or a program, hereinafter also referred to as
  • Computer program product which receives or retrieves data from the meter.
  • the received or retrieved data is exploited in the application to determine one or more output values.
  • the data is processed and / or evaluated by the application in accordance with the approaches described herein.
  • processors and one or more
  • Memory blocks of the arithmetic unit are used.
  • the arithmetic unit can also be designed to outsource computation steps for executing the application.
  • the application can transmit the data received or requested by the measuring device to an external computing unit. Before the data are transmitted to the external arithmetic unit, they can be fed to preprocessing.
  • the external processing unit may be physically remote from the meter and the portable
  • the portable computing unit may be connected to the external computing unit via the data network, i. are in a communication connection.
  • the external processing unit may be a single computer or processor or a composite of computers or processors. In a computer or processor network, the
  • this computer network can also provide storage capacities for Provide users and keep data shared or tagged by users. Thus, the space required in the portable computing unit can be reduced. It also makes it easier for the user to exchange a portable computing unit, because locally no or almost no data is stored.
  • the computer network can be configured as a group of meshed networked servers.
  • the detection unit is configured to light in one
  • the detection unit is executed, which indicates the light emitted in the direction of the skin surface to be examined over the whole
  • Wavelength range to emit
  • light is emitted over the entire spectrum of the first wavelength range in the direction of the skin surface to be examined in order to irradiate the skin surface to be examined over a broadband range.
  • light is detected over the entire specified wavelength range by the detection unit in order to determine a spectrum of the light reflected and / or emitted by autofluorescence.
  • this has to be examined in the direction of
  • Skin surface emitted light at the wavelength of 370 nm has a higher intensity than the other wavelengths of the first wavelength range.
  • the emitted light has a higher intensity.
  • AGEs in the skin can react in particular to light around 370 nm and be excited to autofluorescence. If the light has a higher intensity at this wavelength, a measurement result can have a higher accuracy.
  • the intensity of the light at 370 nm or in the specified range around 370 nm may have an intensity that is at least two times higher than the intensity at the remaining wavelengths of the first wavelength range.
  • the detection unit has a spectrometer which is designed to detect the reflected light and the light emitted by autofluorescence in the wavelength range mentioned.
  • the spectrometer is designed to reflect the reflected light in the first
  • the spectrometer can detect the intensity and a spectral profile of the intensity in the first and second wavelength range and provide it for further processing. This may result in a typical course of the intensity of the light in the first and second wavelength range for an examined skin or a examined area of the skin. From this typical course can be concluded that the condition of the examined skin. It is possible to deduce from said typical course treatment agents and / or instructions for use or treatment instructions for the examined skin, in order to influence or change a state of the examined skin in a desired or desirable direction. For example, one goal of treating agents may be to reduce or at least not increase the level of AGEs in the skin. Depending on the condition of the examined skin, treatment agents may be recommended for this purpose and / or instructions for use thereof
  • Treating agents and / or general treatment instructions are expressed with or without reference to the treatment agent.
  • the arrangement described herein makes it possible to easily monitor or understand the efficacy of the treatment and or treatment agent, thereby facilitating the selection of an individually suitable treatment agent and / or the provision of instructions for use.
  • suitable treating agents may include ingredients that result in degradation of the existing AGEs (e.g., combination of red-root leaf extract and vitamin B3) or that inhibit the regeneration of AGEs (e.g., antioxidants, such as antioxidants)
  • ingredients that result in degradation of the existing AGEs e.g., combination of red-root leaf extract and vitamin B3
  • antioxidants such as antioxidants
  • High sun protection factor treatments are suitable for reducing the formation of AGEs. Suitable sun protection factors include, for example, benzophenone-3,
  • Benzophenone-4 benzophenone-5, 3-benzylidene camphor, benzylidene-sulfonic acid, bis-ethylhexyloxyphenol-methoxyphenyltriazine (BEMT), butylmethoxydibenzoylmethane (BMDM, avobenzone), diethylhexylbutamidotriazone, dimethicodiethylbenzalmalonate, dimethyl
  • Phenylbenzimidazole sulfonic acid PBSA
  • disodium phenyldibenzimidazole tetrasulfonate DPDT
  • polyacrylamidomethylbenzylidene camphor terephthalidene diceramide sulfonic acid (TDSA) and salts, titania or mixtures of these sun protection factors.
  • a user with an elevated or high level of AGE in the skin may be advised to use treatment agents containing ingredients that degrade AGEs and / or inhibit and / or reduce their replication.
  • treatment agents containing ingredients that degrade AGEs and / or inhibit and / or reduce their replication may be recommended, for example, excessive UV radiation of his skin by wearing protective clothing outdoors, especially in strong sunlight, and / or
  • the spectrometer is designed to generate a signal pattern which is characteristic for the skin properties, based on the detected light.
  • the evaluation unit is executed, a quotient of the average intensity of the light emitted by autofluorescence and the
  • the content of AGEs in the skin can be determined by determining the autofluorescence of the skin in a specific spectral range. Typically, this will be one
  • Excitation wavelength from 300 nm to 420 nm with an increased intensity at 370 nm or in a range around 370 nm used.
  • the light emission of the skin and the excitation light reflected by the skin are measured by means of a spectrometer, typically in the wavelength range of 300 nm to 600 nm.
  • the spectrometer detects both reflected light and autofluorescence emitting the light. Since the pigmentation of the skin may affect the autofluorescence thereof, e.g. through the formation of the following
  • Quotients are normalized: (average intensity of the emitted light at 420 nm to 600 nm) / (average intensity of the reflected excitation light between 300 nm and 420 nm).
  • the equipment required for this purpose is hand portable (portable), ie operable and portable in one hand.
  • the display unit has a surface up to 36 cm 2 , but may be larger.
  • the arrangement further comprises an energy store which is arranged in the housing in order to supply the evaluation unit and the user interface with energy in order at least temporarily to allow autonomous operation of the evaluation unit and the user interface without connection to an external energy source.
  • the energy store is preferably a rechargeable energy store.
  • the evaluation unit is executed, the
  • Data storage unit to reach over a data network.
  • the data storage unit is arranged spatially separated from the evaluation unit.
  • the data storage unit is arranged such that a variety of arrangements as described herein can access the data storage unit.
  • current information can be supplied to requesting arrangements.
  • experience from other users can be considered.
  • the evaluation unit is designed to match the characteristics of treatment agents for the non-therapeutic treatment of a body surface with the determined skin properties and an effect of the treatment agent on the Body surface, taking into account the determined skin properties and possibly a predetermined treatment goal (eg, a desired or to be reached state of the skin properties) to determine.
  • a predetermined treatment goal eg, a desired or to be reached state of the skin properties
  • treatment agents are selected as a function of the determined skin properties and output on the user interface, for example displayed.
  • the evaluation unit is executed, of which
  • Data storage unit to receive advice on the non-therapeutic treatment of a body surface according to the skin characteristics determined and to instruct the output unit to provide the information received.
  • references may be general (unrelated to a particular treatment) reference regarding the treatment or care of skin, but may also be references to a particular treatment.
  • the clues may also include explanations as to which behaviors influence what features of the body surface (especially skin).
  • the data storage unit can provide information from dermatological studies as well
  • the evaluation unit can be executed, a user depending on the detected
  • Properties of the body surface to display an excerpt from this information, to take into account in the determination of the product and / or treatment recommendation, or at least to point out.
  • the evaluation unit is designed to query information from a user and to additionally take this information into account when interrogating the data storage unit in order to obtain from the data storage unit features of treatment means for non-therapeutic treatment of a body surface according to the queried one
  • the queried information can be detected by means of a predetermined questionnaire, in which a statement by the user is given more or less weight or is selected from one of several possible answers.
  • a predetermined questionnaire in which a statement by the user is given more or less weight or is selected from one of several possible answers.
  • the questionnaire may focus on the user's habits and exceptional pressures, such as dietary habits, duration and quality of sleep, amount of drink, type of drink, use of luxury foods (eg nicotine, alcohol), professional activities and leisure activities (spending time outside of buildings in any weather, staying in the Bergen, visit to a solarium).
  • the requested information may relate to a desired or to be achieved property of the body surface.
  • the evaluation unit has a local memory which is designed to persistently store the data retrieved from the data storage unit.
  • the evaluation unit can perform its functions at least temporarily, without having to rely on a permanent connection to the data storage unit, because the retrieved data is stored in the local memory.
  • the data are stored in the local memory in such a way that they are retained when the evaluation unit is switched off or out of operation (persistent storage). It is possible that the
  • Evaluation unit only retrieves such data from the data storage unit, which match a current image or current characteristics of the skin.
  • data may also be retrieved and stored locally, which will match slightly altered skin characteristics based on the current condition. It is therefore not necessary to retrieve all the data from the data storage unit and store it in the local memory. Rather, you can target those data or information from the
  • Data storage unit are transferred to the local memory, which match the detected state of the skin.
  • the evaluation unit is designed to store the determined skin properties provided with a time stamp relating to the determination of the skin properties in the local memory.
  • the evaluation unit is designed to store the determined skin properties over a longer period comprising at least two processes of detecting the skin properties in the local memory and optionally to retrieve a development of the skin properties over a predefinable period of time from the local memory and to instruct the output unit to do so To spend development, for example to display.
  • the evaluation unit is designed to transmit the determined skin properties to the data storage unit.
  • the determined and transmitted skin properties can be assigned in the data storage unit to a code number or a user identifier, so that a user can view his data from different devices.
  • this approach has the advantage that the data of a user in case of loss or defect of the personal evaluation are secured or deposited at a central location.
  • this embodiment makes it possible to detect a user's skin properties over a longer period of time and to observe their change and, if appropriate, to link these with the recommendations for non-therapeutic treatment agents and / or treatment instructions.
  • the skin properties are properties of the skin of a human user of the arrangement.
  • the arrangement or detection unit is designed to examine those portions of the skin of a human user exposed to the environment, in particular hands / arms, legs / feet, face.
  • this does not preclude the detection unit from examining other portions of a human body and detecting their properties, ie those portions which are not normally exposed to environmental influences over a prolonged period of time, such as the upper body (back, chest, abdomen) and intimate zone /Buttocks.
  • the arrangement is designed to output instructions for the operation of the detection unit visually on the output unit and / or acoustically via a loudspeaker. This can be particularly helpful when the user's body surface is first and comprehensively detected in order to gain an overview of the condition of the skin.
  • the dispensing unit is designed, information regarding ingredients and / or composition of a treatment agent and / or
  • a user is allowed to get an idea of a treatment agent in its entirety.
  • the user may be given application instructions related to a treatment agent or independently thereof.
  • the instructions for use may refer to desired and / or undesired behavior.
  • the user interface is designed to receive an input from a user after issuing features of a treatment agent and to initiate an action regarding the recommended treatment agent based on this input.
  • the action can relate, for example, to the fact that the user is offered a treatment agent for sale and the user can initiate the purchase by means of an entry.
  • the user can also be offered further information on the purchase. This further information may refer to more detailed treatment and application instructions.
  • the program receives the request that the user wants to purchase the treatment agent, stores the request, and / or transmits the request to a trading company which stores the request
  • Input unit the user can be indicated where (for example, drugstore, beauty salon, pharmacy, etc.) he can purchase the treatment.
  • a computer program product configured to be executed on a portable computing unit.
  • the computer program product is designed to instruct a processor of the portable computing unit to carry out the following steps: detecting skin features of a user in the light in one
  • Wavelength range between 200 nm and 420 nm in the direction of a to be examined
  • the surface of the skin is detected and light in a wavelength range between 200 nm and 1500 nm is detected and a proportion of the reflected light and the light emitted by autofluorescence light is detected; Evaluating the detected skin characteristics and determining the skin characteristics based on the detected skin characteristics; Querying a data storage unit under
  • the computer program product enables control and tracking of the results by presenting (e.g., graphically or acoustically) the measurement results over time. Based on the results obtained, the computer program product gives individual treatment and product recommendations. The quality of the treatment and product recommendations may be improved by additionally answering questions about age, gender, weight, skin condition, dietary habits, general health, and / or other behaviors that the computer program product processes. Not only are e.g. Literature data based, but also the treatment success of other users of the computer program product, in particular
  • the data collected by means of the questionnaire can be used to analyze a development of the state of the skin of the user in the given circumstances, that is, the data entered by the user. This development can be compared with the development of other users. From this it can be concluded whether during a treatment with a certain care product the development of users with similar or same inputs in the questionnaire is similar or deviates from users with other inputs.
  • the influence of a particular fact on the success of treatment can be deduced. For example, if the development of a skin parameter in several smokers with a given cigarette consumption (eg, ten cigarettes per day) shows a significant deviation from the development of the same skin parameter in nonsmokers, it can be concluded that smoking has an effect on the particular parameter in a quantifiable manner , Alternatively, it can be concluded that smokers are advised to use another product or treatment.
  • a skin parameter in several smokers with a given cigarette consumption eg, ten cigarettes per day
  • the data entered by the user can thus be used for a global analysis to monitor the success of a treatment and the efficacy of a product under different conditions and to possibly recommend changes to the treatment and / or the product.
  • a recommendation may be to extend sleep time, to reduce the use of semi-luxury foods (alcohol, cigarettes), or to adjust other lifestyle habits.
  • the invention makes it possible to control and track the efficacy of a cosmetic treatment in an objective and standardized manner, with the particular aim of maintaining or structurally altering or improving skin.
  • Effectiveness of the (cosmetic, non-therapeutic) treatment can be better understood and thus the selection of an individually suitable product can be simplified.
  • the invention makes it possible to obtain individual treatment recommendations and product recommendations that respond to the needs of the individual user.
  • it increases the motivation to perform a treatment in the longer term, including comparison with other users and / or observation of the development of one's own skin.
  • FIG. 1 is a schematic representation of an arrangement for determining skin properties according to an embodiment
  • FIG. 2 shows a schematic representation of a data carrier with a computer program product according to a further exemplary embodiment
  • FIG. 3 shows a schematic illustration of a method executed by a computer program product according to an exemplary embodiment
  • FIG. 4 shows a schematic representation of a detection unit for an arrangement according to a further exemplary embodiment.
  • Fig. 1 shows an arrangement 100 for determining skin properties.
  • the arrangement 100 has a detection unit 110, an evaluation unit 120 and a user interface 130.
  • the detection unit 110 is designed to detect properties of a body surface, in particular skin properties, of a human user. To this end, the
  • Detection unit 110 light in a wavelength range between 200 nm and 420 nm, in particular 300 nm and 420 nm with an intensity maximum at 370 nm in the direction of a surface to be examined 12 of the analysis object 10 (for example, the human hand or generally a portion of the body surface) and detects reflected Light in the same wavelength range as well as by autofluorescence-induced light in a wavelength range of 420 nm to 1500 nm. That of the examined
  • Surface area 12 reflects light and the light emitted by autofluorescence is emitted by the detection unit 110 and allows conclusions about the composition and structure of the surface area to be examined 12th
  • the detection unit 110 has a suitable source of electromagnetic waves.
  • This source is a light emitter or laser emitter and may also be referred to as a radiation source and is disposed on or in the detection unit 110.
  • the radiation source may be arranged on or in the detection unit 110 such that when the electromagnetic waves 112 are emitted, the radiation source occupies a predetermined distance from the surface region 12 to be examined, in particular when the detection unit 110 is placed on the surface region to be examined.
  • the distance of the radiation source from the surface area to be examined can be variable and can be changed by means of actuators or manually. It should be noted that for the sake of simplicity, the reflected light and the light emitted by autofluorescence are not shown in FIG.
  • the detection unit 110 is connected to the evaluation unit 120 via a data transmission connection 114.
  • the communication link 114 may be a unidirectional or
  • the detection unit 110 delivers signals relating to the detected features of the skin to the evaluation unit 120, whereas the evaluation unit 120 can supply control commands to the detection unit 110, wherein the control commands specify how the detection unit 110 operates.
  • control parameters can be preset at the detection unit 110 via input elements (buttons, switches, dials, etc., not shown).
  • the detection unit 1 10 has
  • the detection unit 110 can also transmit the set control parameters to the evaluation unit 120, where these can optionally be displayed.
  • the evaluation unit 120 has a processor 126 and a local memory 128.
  • the evaluation unit 120 receives signals relating to the features of the examined
  • the non-therapeutic treatment may include recommendations on treatment agents and / or
  • Treatment notes and application notes are used in the context of this description as synonyms and refer to indications for the non-therapeutic treatment of the examined surface area 12 using selected treatment agents or even without the use of treatment agents.
  • the treatment instructions may contain an indication of desired or undesirable behavior after the application of a treatment agent.
  • the information collected may include:
  • Information about the treatment agents and / or treatment instructions may be stored in a data storage unit 140.
  • the data storage unit 140 may exist outside and spatially separated from the evaluation unit 120.
  • the evaluation unit 120 can access the data storage unit 140 via a data network 122 and information about the treatment agents stored there and / or
  • Evaluation unit 120 aligned with the detected features of the surface area 12 to be examined in order to determine appropriate recommendations for the non-therapeutic treatment of the examined surface area.
  • the data storage unit is retrieved using the determined skin characteristics. From the data storage unit, a plurality of stored information can first be retrieved in order to then filter which of the treatment means and / or. Using the ascertained skin properties and possibly of treatment objectives
  • Treatment instructions are relevant.
  • the data from the data memory can be loaded into a volatile main memory.
  • the ascertained skin properties can already be used when retrieving the information from the data store in order to retrieve only the relevant information from the data store.
  • these two variants may be considered equivalent in their effect.
  • the data network 122 may be a public data transmission network which has partially wired or wireless transmission sections.
  • the evaluation unit 120 may establish a wireless connection to an access point (not shown) to the data network 122 in order to be able to establish a corresponding connection to the data storage unit 140.
  • the user interface 130 is connected to the evaluation unit 120 via the data transmission connection 124.
  • the user interface 130 has an input unit 132 and a
  • the input unit 132 allows a user to specify parameters for the operation and configuration of the evaluation unit 120, the detection unit 110 and / or the user interface 130.
  • the input unit 132 can record information via various interfaces: a keyboard, a mouse, a touch-sensitive display or via a microphone (so-called voice control). It is conceivable that any interface is used via which a human user communicate with a computing unit and enter data or can pass.
  • the output unit 134 may be a display or other display unit that outputs visual information to a user. Also, the output unit 134 may have a speaker through which acoustic information can be output. Visual information may be output on a touch-sensitive output unit so that the output unit also allows a user to make inputs thereon.
  • the evaluation unit 120 has a processor 126 and a local memory 128.
  • the processor 126 executes instructions to perform its intended function or functions.
  • the local memory 1228 the features of the skin detected by the detection unit 110 or the associated signals or values can be stored.
  • the detection unit 110 can be operated with an evaluation unit 120 and a user interface 130, which are implemented in a portable device of a user or consumer.
  • a detection unit 110 which allows advanced analysis and investigation possibilities for a body surface (skin) of a human user, with a portable computerized data processing device.
  • the portable data processing device can be, for example, a smartphone, phablet or a tablet and a home computer.
  • the detection unit 1 10 can by means of a defined
  • FIG. 2 shows a data carrier 300.
  • the data carrier stores a computer program product which is designed to be executed on a portable computing unit 120 and to instruct a processor of the portable computing unit 126 to carry out the following steps: detecting skin features of a user in the light a wavelength range between 200 nm and 420 nm is emitted in the direction of a skin surface to be examined and light in a wavelength range between 200 nm and 1500 nm is detected and a proportion of the reflected light and the light emitted by autofluorescence light is detected; Evaluating the detected skin characteristics and determining the skin characteristics based on the detected skin characteristics; Polling a data storage unit 140 using the determined skin characteristics; Obtain characteristics of treatment agents and / or
  • Output unit (134) to output information on the treatment agents and / or application notes.
  • the data carrier 300 can use magnetic, optical or electrical storage techniques (or combinations thereof) to implement the instructions of the computer program product in one machine-readable form vorzuhalten. These instructions may be used to be executed directly by the processor 126 of the portable computing unit 120 (the evaluation unit 120 of the embodiment of FIG. 1). Alternatively, the instructions may be used to load the computer program product into an internal memory of the portable computing unit 120 for execution therefrom. This internal memory may be, for example, the local memory 128 of FIG. 1.
  • the computer program product may be loaded onto a user's portable device via a data network and installed on the portable device for use by the user.
  • FIG. 3 shows a method 400 with the following steps (these steps correspond to the functions of the computer program product): in a first step 410, skin characteristics of a user are detected by applying light in a wavelength range between 200 nm and 420 nm emitted in the direction of a skin surface to be examined and light in a wavelength range between 200 nm and 1500 nm is detected and a proportion of the reflected light and the light emitted by autofluorescence light is detected; in a second step 420, the detected skin characteristics are evaluated and skin properties are determined based on the detected skin characteristics; in a third step 430, a data storage unit 140 is queried using the ascertained skin characteristics (this may mean, for example, that the skin properties are transferred to the data store 140 and the data store returns data or information in response thereto); in a fourth step 440, features of treatment agents and / or
  • the computer program product includes instructions that instruct the processor 126 of the portable computing unit 120 to perform these steps 410-450.
  • the method 400 or its steps 410-450 may be in accordance with one of the embodiments of the arrangement 100, as with reference to FIG. 1 and the remainder
  • circuit is to be understood as any entity that implements logic, and may be hardware, software, firmware, or any combination thereof.
  • a “circuit” may be a hard-wired logic circuit or a programmable logic circuit, such as a programmable processor, such as a microprocessor or field programmable gate array (FPGA) device.
  • a “circuit” can also be understood to mean a processor that executes software, for example any type of computer program, such as a computer program in programming code for a virtual machine (delimited runtime environment, virtual machine), such as a Java computer -Program.
  • a “circuit” may be understood as any type of implementation of the functions described below.
  • the detection unit has a surface 111, at which a light emitter 116 and a spectrometer 118 are shown.
  • the light emitter 116 is shown in a circle and the spectrometer 118 is shown quadrangular.
  • the light emitters 116 emit the light rays out of the plane of the drawing toward a viewer.
  • the processor 126 may implement control functions and output control commands to the light emitter 116.
  • the processor 126 may drive the light emitter to output light of some intensity, wavelength, and / or spectral distribution (these may be referred to as parameters of the light).
  • the evaluation unit 120 with the processor 126 also receives the signals of the
  • Spectrometer 118 can classify the examined body surface based on these signals.
  • the signals provided by the spectrometer 118 are indicative of the body surface.
  • These signals can also be referred to as signal patterns and can be used to determine and output a product recommendation and / or application instructions. It is conceivable that a product and / or an application advice a typical
  • Signal pattern is assigned, in which the product and or the application note can be usefully used.
  • This associated signal pattern of the products and / or the application instructions can be compared with the actual signal pattern. At some degree, the conformity of the signal pattern acquired or supplied by the spectrometer with that associated with the products and / or application instructions
  • Signal patterns can then be output the corresponding products and / or application notes.
  • the signals may be for qualitative similarity (corresponding to the shapes or courses of the signals) and / or quantitative similarity (for signals having similar input values, i.e., light, similar output values, i.e., reflected light or through

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  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
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  • Molecular Biology (AREA)
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  • Animal Behavior & Ethology (AREA)
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Abstract

L'invention concerne un dispositif (100) pour la détermination de propriétés de la peau. Le dispositif comprend : une unité de détection (110) pour la détection de caractéristiques de la peau ; une unité d'évaluation (120) pour l'évaluation des caractéristiques de la peau détectées et pour la détermination de propriétés de la peau sur la base des caractéristiques de la peau détectées ; et une interface utilisateur (130) qui comprend une unité de sortie (134), l'interface utilisateur étant conçue pour interagir avec un utilisateur. L'unité d'évaluation (120) est conçue pour interroger une unité de stockage de données (140) en utilisant les propriétés de la peau déterminées, pour recevoir de l'unité de stockage de données (140) des caractéristiques de moyens de traitement et/ou des indications d'utilisation pour le traitement non-thérapeutique d'une surface corporelle conformément aux propriétés de la peau déterminées, et pour commander à l'unité de sortie (134) de sortir des informations concernant les moyens de traitement et/ou les indications d'utilisation à un utilisateur. L'unité d'évaluation (120) est une unité de calcul portable et l'unité de détection est conçue pour émettre de la lumière dans une plage de longueurs d'onde comprise entre 200 nm et 420 nm en direction d'une surface de la peau à examiner, pour détecter la lumière dans une plage de longueurs d'onde comprise entre 200 nm et 1500 nm et pour déterminer une proportion de la lumière réfléchie et de la lumière émise par autofluorescence.
PCT/EP2018/082149 2017-12-12 2018-11-22 Dispositif de détermination de métabolites finis dans la peau WO2019115194A1 (fr)

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DE102017222530.0A DE102017222530A1 (de) 2017-12-12 2017-12-12 Anordnung zum Ermitteln von Stoffwechselendprodukten in der Haut

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Families Citing this family (1)

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Publication number Priority date Publication date Assignee Title
US20190307390A1 (en) * 2018-04-09 2019-10-10 Massachusetts Institute Of Technology Device and method for detecting disease states associated with lipopigments

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060092315A1 (en) * 2004-10-29 2006-05-04 Johnson & Johnson Consumer Companies, Inc. Skin Imaging system with probe
US20100185064A1 (en) * 2007-01-05 2010-07-22 Jadran Bandic Skin analysis methods
KR20120114777A (ko) * 2011-04-08 2012-10-17 한국전기연구원 최종당화산물의 자가형광 측정 장치
US20140058227A1 (en) * 2011-05-26 2014-02-27 Sharp Kabushiki Kaisha Measuring device, and measuring method

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2042075C (fr) * 1991-05-08 2001-01-23 Branko Palcic Systeme d'imagerie endoscopique
US5556612A (en) * 1994-03-15 1996-09-17 The General Hospital Corporation Methods for phototherapeutic treatment of proliferative skin diseases
US6462770B1 (en) * 1998-04-20 2002-10-08 Xillix Technologies Corp. Imaging system with automatic gain control for reflectance and fluorescence endoscopy
FR2784188B1 (fr) * 1998-10-05 2000-12-22 Commissariat Energie Atomique Biopuce et dispositif de lecture d'une biopuce comportant une pluralite de zones de reconnaissance moleculaire
FR2784189B3 (fr) * 1998-10-05 2000-11-03 Commissariat Energie Atomique Biopuce et dispositif de lecture d'une biopuce comportant une pluralite de zones de reconnaissance moleculaire
AU6232099A (en) * 1999-09-30 2001-04-30 Jipjap B.V. Method and apparatus for determining autofluorescence of skin tissue
WO2001045557A1 (fr) * 1999-12-22 2001-06-28 Xillix Technologies Corporation Systeme portable permettant la detection des anomalies cutanees sur la base d'autofluorescence caracteristique
FR2834340B1 (fr) * 2001-12-28 2004-07-16 Mauna Kea Technologies Appareillage de spectroscopie d'autofluorescence subsurfacique
JP4485471B2 (ja) * 2003-11-19 2010-06-23 リチャード ウルフ ゲーエムベーハー 組織診断用の画像提供装置
JP4814529B2 (ja) * 2005-02-16 2011-11-16 Ｈｏｙａ株式会社 画像処理装置
DE102007052858A1 (de) * 2006-11-02 2008-05-15 Heidelberg Engineering Gmbh Verfahren und Gerät zur Netzhautdiagnostik
CN101716069A (zh) * 2009-11-17 2010-06-02 中国科学院安徽光学精密机械研究所 人体氧化应激无创荧光检测装置与方法
ES2576202T3 (es) * 2010-06-18 2016-07-06 Diagnoptics Holding B.V. Método y aparato para determinar un valor de autofluorescencia de tejido de piel
US9155473B2 (en) * 2012-03-21 2015-10-13 Korea Electrotechnology Research Institute Reflection detection type measurement apparatus for skin autofluorescence
US20150201840A1 (en) * 2013-03-18 2015-07-23 Korea Electrotechnology Research Institute Reflection detection type measurement apparatus for skin autofluorescence
US9456777B2 (en) * 2013-08-23 2016-10-04 Elwha Llc Systems, methods, and devices for assessing microbiota of skin
FR3044414B1 (fr) * 2015-11-30 2020-10-16 Univ De Lorraine Dispositif medical de spectroscopie optique bimodale fibree

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060092315A1 (en) * 2004-10-29 2006-05-04 Johnson & Johnson Consumer Companies, Inc. Skin Imaging system with probe
US20100185064A1 (en) * 2007-01-05 2010-07-22 Jadran Bandic Skin analysis methods
KR20120114777A (ko) * 2011-04-08 2012-10-17 한국전기연구원 최종당화산물의 자가형광 측정 장치
US20140058227A1 (en) * 2011-05-26 2014-02-27 Sharp Kabushiki Kaisha Measuring device, and measuring method

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