WO2019071648A1 - 一种用于胚胎、卵母细胞或干细胞的成像系统 - Google Patents

一种用于胚胎、卵母细胞或干细胞的成像系统 Download PDF

Info

Publication number
WO2019071648A1
WO2019071648A1 PCT/CN2017/106976 CN2017106976W WO2019071648A1 WO 2019071648 A1 WO2019071648 A1 WO 2019071648A1 CN 2017106976 W CN2017106976 W CN 2017106976W WO 2019071648 A1 WO2019071648 A1 WO 2019071648A1
Authority
WO
WIPO (PCT)
Prior art keywords
disk
embryos
disc
oocytes
stem cells
Prior art date
Application number
PCT/CN2017/106976
Other languages
English (en)
French (fr)
Inventor
云新
Original Assignee
武汉互创联合科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 武汉互创联合科技有限公司 filed Critical 武汉互创联合科技有限公司
Publication of WO2019071648A1 publication Critical patent/WO2019071648A1/zh

Links

Images

Classifications

    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/50—Constructional details
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N17/00—Diagnosis, testing or measuring for television systems or their details
    • H04N17/002—Diagnosis, testing or measuring for television systems or their details for television cameras
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/50—Constructional details
    • H04N23/54—Mounting of pick-up tubes, electronic image sensors, deviation or focusing coils
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/50—Constructional details
    • H04N23/55—Optical parts specially adapted for electronic image sensors; Mounting thereof

Definitions

  • the present invention relates to a biotechnology medical aid, and more particularly to an imaging system for embryos, oocytes or stem cells.
  • ART assisted reproductive technology
  • a circular embryonic tray is typically provided on a circumference of the top surface of a disc, the embryo tray being spaced apart from a plurality of embryos, and the quality of the plurality of embryos is evaluated by photographing the plurality of embryos.
  • an operation evaluated fewer embryos and was less efficient.
  • the object of the present invention is to provide an efficient imaging system for embryos, oocytes or stem cells for evaluating a plurality of embryos in view of the above-mentioned status quo.
  • an imaging system for embryos, oocytes or stem cells comprising a disk, a plurality of carrier trays disposed on the disk, and photographing the plurality of carrier trays
  • An optical system each of the carrier trays is evenly provided with a plurality of recesses for bearing Embrying embryos, oocytes or stem cells, and the centers of the plurality of depressions on each of said carrier trays are in line with the center of said disk, said disks being rotated about their centers
  • said optical system comprising a light source, a concentrating device, an objective lens, and a charge coupled device image sensor, the concentrating device, the disk, the objective lens, and the charge coupled device image sensor are sequentially disposed on an optical path of the light source, when the disk is not Upon rotation, the optical system and disk are relatively translated along a line passing through the center of the disk; as the disk rotates, the optical system and disk are relatively stationary.
  • the effect of the invention is that the imaging system for embryos, oocytes or stem cells can simultaneously evaluate a plurality of embryos, oocytes or stem cells, saving time and being more efficient.
  • FIG. 1 is a schematic view showing the structure of an imaging system for embryos, oocytes or stem cells provided by the present invention.
  • Figure 2 is a plan view of the disk of Figure 1.
  • FIG. 1 is a schematic structural diagram of an imaging system for embryos, oocytes or stem cells according to the present invention.
  • the imaging system for embryos, oocytes or stem cells is coupled to an external computer so that it can communicate with the computer and has software for analyzing images acquired by the imaging system.
  • the imaging system for embryos, oocytes or stem cells comprises a disk 1, a plurality of carrier trays 2 disposed on the disk 1, and an optical system 3 for taking pictures of the carrier tray 2.
  • the disc 1 is radially disposed from the center of the circle with a plurality of partitions 11, and the plurality of partitions 11 are evenly disposed.
  • the plurality of partitions 11 divide the disc 1 into a plurality of sectoral regions.
  • the disc 1 is provided with a groove 12 in the middle of each sector.
  • Each groove 12 grows in a strip shape and extends from a center of the disc 1 away from the center of the circle, so that the plurality of grooves 12 are radially outwardly disposed from the center of the disk 1, and the grooves 12 are radially outwardly disposed. Evenly set.
  • the disc 1 is rotated about its center, and the angle of each rotation is related to the number of the partitions 11. That is, when the number of the partition plates 11 is N, the angle at which the disk 1 rotates each time is 360/N degrees. In the present embodiment, the angle at which the disk 1 is rotated each time is 30 degrees.
  • the carrier tray 2 is disposed within the recess 12 of the disc 1 for carrying a number of embryos, oocytes or stem cells.
  • the plurality of carrier trays 2 are radially outwardly disposed from the center of the disk 1, and the plurality of carrier trays 2 are evenly disposed.
  • Each of the carrier trays 2 is uniformly provided with a plurality of circular recesses 21, and the centers of the plurality of recesses 21 on each of the carrier trays 2 are located on the same line as the center of the disk 1.
  • each of the carrier trays 2 is uniformly provided with nine circular recesses 21, each of which carries an embryo, an oocyte or a stem cell.
  • the optical system 3 includes a light source 31, a light collecting device 32, an objective lens 33, a refractive device 34, and a charge coupled device image sensor 35 (CCD), a light collecting device 32, a disk 1, an objective lens 33, a refractive device 34, and a charge-coupling device.
  • the image sensor 35 is sequentially disposed on the optical path of the light source 31.
  • Light source 31 can be an LED light source.
  • the concentrating device 32 is disposed directly under the light source 31.
  • the concentrating device 32 is a condensing mirror for concentrating the light generated by the light source 31. Since the disk 1 is disposed directly below the concentrating device 32, the concentrating device 32 causes the light of the light source 31 to converge on the disk 1 to a point. .
  • the objective lens 33 is disposed below the disk 1 and corresponds to the concentrating device 32.
  • the refractive device 34 is disposed below the objective lens 33 and corresponds to the objective lens 33.
  • the charge coupled device image sensor 35 is disposed on one side of the refractive device 34 and corresponds to the refractive surface of the refractive device 34.
  • the entire imaging system may not be provided with the refraction device 34, the refraction device 34
  • the setup is to shorten the vertical distance of the entire imaging system.
  • the optical system 3 is integrated as a whole, and when the disk 1 is rotated, the optical system 3 and the disk 1 are relatively stationary. When the disc 1 is not rotated, it can be relatively translated along a straight line passing through the center of the disc 1. Specifically, there are two ways: the disc 1 does not translate, and the optical system 3 translates along a straight line passing through the center of the disc 1. The optical system 3 does not translate, and the disk 1 is translated along a straight line passing through the center of the disk 1.
  • the optical system 3 first photographs the embryo, oocyte or stem cell in the first recess 21 on one of the carrier trays 2, and at this time, translates the disc 1 or the optical system 3, and sequentially carries the load.
  • the other depressions 21 on the tray 2 are photographed.
  • all the depressions 21 on the carrier tray 2 are photographed, after rotating the center of the disk 1 by a certain angle (the angle is preset), all the depressions 21 on the adjacent other carrier tray 2 are photographed. , repeated in turn until the embryos, oocytes or stem cells in all of the depressions 21 on the disc 1 are photographed.
  • the imaging system for embryos, oocytes or stem cells can simultaneously evaluate a plurality of embryos, oocytes or stem cells, saving time and being more efficient.
  • the presence or absence of the partition 11, the number of the partitions 11, the angle at which the disc 1 is rotated, and the number of the recesses 21 on each of the trays 2 are not limited, and can be adjusted according to actual conditions.

Abstract

一种用于胚胎、卵母细胞或干细胞的成像系统，包括圆盘（1）、设置在所述圆盘（1）上的若干载物托盘（2）、以及为所述若干载物托盘进行拍照的光学系统（3），所述圆盘（1）自其圆心向外辐射状设置有若干隔板（11），且所述若干隔板（11）均匀设置，所述若干隔板（11）将所述圆盘（1）分隔成若干扇形区域，所述若干载物托盘（2）分别均匀设置在所述若干扇形区域内，每一所述载物托盘（2）均匀设置有若干凹陷（21），所述光学系统依次包括光源（31）、聚光装置（32）、物镜（33）、和电荷藕合器件图像传感器（35）。该用于胚胎、卵母细胞或干细胞的成像系统可同时对多个胚胎、卵母细胞或干细胞进行拍照评价，节约时间，更为高效。

Description

一种用于胚胎、卵母细胞或干细胞的成像系统 技术领域
本发明涉及一种生物科技医疗辅助设备，尤其涉及一种用于胚胎、卵母细胞或干细胞的成像系统。
背景技术
在过去30年里，辅助生殖技术(ART)彻底改变了人类不育(infertility)的治疗，并且已经变得普遍。然而，ART需要使用多个胚胎，多个胚胎导致了高发性的多胎妊娠，从而使得婴儿和母亲的死亡率和痛苦大大增加，并产生很大的经济成本。
ART成功率低的主要原因之一在于缺乏用于对胚胎质量进行评价的方法。目前用于预测胚胎质量的最可靠的方法是在转移前使用标准透射光学显微系统对胚胎形态学进行拍照检查。通常在某一圆盘的顶面的某一圆周设有一环形的胚胎托盘，该胚胎托盘上间隔设置有若干胚胎，通过对该若干胚胎进行照相来评价该若干胚胎的质量。然而，这样的一次操作所评价的胚胎数量较少，效率较低。
发明内容
本发明的目的是针对上述现状，提供一种对多个胚胎进行评价的高效的用于胚胎、卵母细胞或干细胞的成像系统。
本发明采用的技术方案：一种用于胚胎、卵母细胞或干细胞的成像系统，包括圆盘、设置在所述圆盘上的若干载物托盘、以及为所述若干载物托盘进行拍照的光学系统，每一所述载物托盘均匀设置有若干凹陷用于承 载胚胎、卵母细胞或干细胞，且每一所述载物托盘上的若干凹陷的中心与所述圆盘的圆心位于同一直线上，所述圆盘绕其圆心旋转，所述光学系统依次包括光源、聚光装置、物镜、和电荷藕合器件图像传感器，所述聚光装置、圆盘、物镜和电荷藕合器件图像传感器依次设置在所述光源的光学路径上，当所述圆盘不旋转时，所述光学系统和圆盘沿通过所述圆盘的圆心的直线相对平移；当所述圆盘旋转时，所述光学系统和圆盘相对不动。
本发明的效果是：该用于胚胎、卵母细胞或干细胞的成像系统可同时对多个胚胎、卵母细胞或干细胞进行拍照评价，节约了时间，更为高效。
附图说明
图1为本发明提供的一种用于胚胎、卵母细胞或干细胞的成像系统的结构示意图。
图2为图1中圆盘的俯视图。
具体实施方式
以下结合附图对本发明的原理和特征进行描述，所举实例只用于解释本发明，并非用于限定本发明的范围。
请参阅图1，为本发明提供的一种用于胚胎、卵母细胞或干细胞的成像系统的结构示意图。该用于胚胎、卵母细胞或干细胞的成像系统与外部计算机联接，从而可以与该计算机通信，且该计算机内具有用于分析由该成像系统获取的图像的软件。
该用于胚胎、卵母细胞或干细胞的成像系统包括圆盘1、设置在圆盘1上的若干载物托盘2、以及为载物托盘2进行拍照的光学系统3。
请同时参阅图2，圆盘1自其圆心向外辐射状设置有若干隔板11，且该若干隔板11均匀设置。该若干隔板11将圆盘1分隔成若干扇形区域， 且圆盘1于每一扇形区域中部均设有一凹槽12。每一凹槽12成长条状，且自靠近圆盘1圆心处向远离圆心的方向延伸设置，从而使该若干凹槽12自圆盘1的圆心向外辐射状设置，且该若干凹槽12均匀设置。于本实施例中，隔板11和凹槽12均有12个。
圆盘1绕其圆心转动，且每次旋转的角度与隔板11的数量有关。即隔板11的数量为N时，圆盘1每次旋转的角度为360/N度。于本实施例中，圆盘1每次旋转的角度为30度。
载物托盘2设置在圆盘1的凹槽12内，用于承载若干胚胎、卵母细胞或干细胞。该若干载物托盘2自圆盘1的圆心向外辐射状设置，且该若干载物托盘2均匀设置。每一载物托盘2均匀设置有若干圆形的凹陷21，且每一载物托盘2上的若干凹陷21的中心与圆盘1的圆心位于同一直线上。于本实施例中，每一载物托盘2上均匀设置有九个圆形的凹陷21，每一凹陷21内承载一个胚胎、卵母细胞或干细胞。
光学系统3包括光源31、聚光装置32、物镜33、折射装置34和电荷藕合器件图像传感器35(CCD)，聚光装置32、圆盘1、物镜33、折射装置34和电荷藕合器件图像传感器35依次设置在光源31的光路上。
光源31可为LED光源。
聚光装置32设置在光源31的正下方。聚光装置32为聚光镜，用于对光源31产生的光线进行汇聚，由于圆盘1设置在聚光装置32的正下方，从而聚光装置32使光源31的光线在圆盘1上汇聚成一点。
物镜33设置在圆盘1的下方，且与聚光装置32对应。
折射装置34设置在物镜33的下方，且与物镜33对应。
电荷藕合器件图像传感器35设置在折射装置34的一侧，且对应折射装置34的折射面。
可以理解地，整个成像系统也可以不设置折射装置34，折射装置34的 设置是为了缩短整个成像系统的竖直距离。
另外，光学系统3做为一个整体，当圆盘1旋转时，光学系统3和圆盘1相对不动。当圆盘1不旋转时，可沿通过圆盘1的圆心的直线相对平移，具体地，有以下两种方式：圆盘1不平移，光学系统3沿通过圆盘1的圆心的直线进行平移；光学系统3不平移，圆盘1沿通过圆盘1的圆心的直线进行平移。
具体操作时，光学系统3先对其中一个载物托盘2上的第一个凹陷21内的胚胎、卵母细胞或干细胞进行拍照，此时平移圆盘1或光学系统3，依次对该载物托盘2上的其它凹陷21进行拍照。该载物托盘2上的所有凹陷21拍照完成后，绕圆盘1的圆心旋转一定角度(该角度预先设定好)后，对相邻的另一载物托盘2上的所有凹陷21进行拍照，依次反复，直到圆盘1上的所有所有凹陷21内的胚胎、卵母细胞或干细胞拍照完成为止。
如此，该用于胚胎、卵母细胞或干细胞的成像系统可同时对多个胚胎、卵母细胞或干细胞进行拍照评价，节约了时间，更为高效。
可以理解地，隔板11的有无、隔板11的数量、圆盘1每次旋转的角度、每一载物托盘2上的凹陷21的数量并不限定，均可根据实际情况进行调整。
以上所述仅为本发明的较佳实施例，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。

Claims (10)

  1. 一种用于胚胎、卵母细胞或干细胞的成像系统，其特征在于：包括圆盘、设置在所述圆盘上的若干载物托盘、以及为所述若干载物托盘进行拍照的光学系统，每一所述载物托盘均匀设置有若干凹陷用于承载胚胎、卵母细胞或干细胞，且每一所述载物托盘上的若干凹陷的中心与所述圆盘的圆心位于同一直线上，所述圆盘绕其圆心旋转，所述光学系统依次包括光源、聚光装置、物镜、和电荷藕合器件图像传感器，所述聚光装置、圆盘、物镜和电荷藕合器件图像传感器依次设置在所述光源的光学路径上，当所述圆盘不旋转时，所述光学系统和圆盘沿通过所述圆盘的圆心的直线相对平移；当所述圆盘旋转时，所述光学系统和圆盘相对不动。
  2. 如权利要求1所述的一种用于胚胎、卵母细胞或干细胞的成像系统，其特征在于：所述圆盘自其圆心向外辐射状设置有若干隔板，且所述若干隔板均匀设置，所述若干隔板将所述圆盘分隔成若干扇形区域，所述若干载物托盘分别均匀设置在所述若干扇形区域内。
  3. 如权利要求2所述的一种用于胚胎、卵母细胞或干细胞的成像系统，其特征在于：所述圆盘于每一扇形区域中部均设有一凹槽，每一所述凹槽自靠近所述圆盘的圆心处向远离圆心的方向延伸设置，从而使所述若干凹槽自所述圆盘的圆心向外辐射状设置，且所述若干凹槽均匀设置，所述若干载物托盘收容在所述若干凹槽内。
  4. 如权利要求3所述的一种用于胚胎、卵母细胞或干细胞的成像系统，其特征在于：所述隔板和凹槽均有12个，所述圆盘每次旋转的角度为30度。
  5. 如权利要求4所述的一种用于胚胎、卵母细胞或干细胞的成像系统，其特征在于：每一所述载物托盘上均匀设置有9个凹陷，每一所述凹 陷承载一个胚胎、卵母细胞或干细胞。
  6. 如权利要求2所述的一种用于胚胎、卵母细胞或干细胞的成像系统，其特征在于：所述隔板的数量为N，所述圆盘每次旋转的角度为360/N度。
  7. 如权利要求1所述的一种用于胚胎、卵母细胞或干细胞的成像系统，其特征在于：所述光学系统还包括折射装置，所述折射装置设置在所述物镜和电荷藕合器件图像传感器之间。
  8. 如权利要求7所述的一种用于胚胎、卵母细胞或干细胞的成像系统，其特征在于：所述聚光装置设置在所述光源的正下方，所述聚光装置为聚光镜，所述物镜设置在所述圆盘的下方，且与所述聚光装置对应，所述折射装置设置在所述物镜的下方，且与所述物镜对应，所述电荷藕合器件图像传感器设置在所述折射装置的一侧，且对应所述折射装置的折射面。
  9. 如权利要求1所述的一种用于胚胎、卵母细胞或干细胞的成像系统，其特征在于：当所述圆盘不旋转时，所述圆盘不平移，所述光学系统沿通过所述圆盘的圆心的直线进行平移。
  10. 如权利要求1所述的一种用于胚胎、卵母细胞或干细胞的成像系统，其特征在于：当所述圆盘不旋转时，所述光学系统不平移，所述圆盘沿通过所述圆盘的圆心的直线进行平移。
PCT/CN2017/106976 2017-10-12 2017-10-20 一种用于胚胎、卵母细胞或干细胞的成像系统 WO2019071648A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710944970.0 2017-10-12
CN201710944970.0A CN107749936A (zh) 2017-10-12 2017-10-12 一种用于胚胎、卵母细胞或干细胞的成像系统

Publications (1)

Publication Number Publication Date
WO2019071648A1 true WO2019071648A1 (zh) 2019-04-18

Family

ID=61252503

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2017/106976 WO2019071648A1 (zh) 2017-10-12 2017-10-20 一种用于胚胎、卵母细胞或干细胞的成像系统

Country Status (2)

Country Link
CN (1) CN107749936A (zh)
WO (1) WO2019071648A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108795762A (zh) * 2018-07-25 2018-11-13 太平洋康泰科学仪器（济南）有限公司 一种时差成像培养系统及其方法
CN109946825A (zh) * 2019-02-15 2019-06-28 武汉互创联合科技有限公司 一种用于胚胎、卵母细胞和干细胞的双向成像系统
CN115558593A (zh) * 2022-09-02 2023-01-03 广州市华粤行医疗科技有限公司 一种介质培养观察装置及其气路控制方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4800164A (en) * 1984-07-12 1989-01-24 Institut National De La Sante Et De La Recherche Medicale-Inserm Automatic device for the analysis and cloning of cellular cultures as well as for bacteriological analysis
WO2002033047A2 (en) * 1998-04-28 2002-04-25 Nexgenics Bioscience Corp. In vitro embryo culture device
CN1894397A (zh) * 2003-12-18 2007-01-10 株式会社日立医药 细胞培养装置
CN103517676A (zh) * 2010-09-27 2014-01-15 奥克索金股份有限公司 用于胚胎、卵母细胞和干细胞的自动化成像和评价的装置、方法和系统
CN103642688A (zh) * 2007-06-29 2014-03-19 尤尼森斯繁殖技术公司 用于监测和/或培养显微对象的设备、系统和方法
CN105136665A (zh) * 2015-08-17 2015-12-09 宁波键一电子信息技术有限公司 箱内活细胞培养网络型智能成像分析仪
CN106164245A (zh) * 2014-02-03 2016-11-23 尤尼森斯繁殖技术公司 培育器装置及方法
CN106999926A (zh) * 2014-06-02 2017-08-01 安捷伦科技有限公司 用于分析生物样本的单列微板系统和载体

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4800164A (en) * 1984-07-12 1989-01-24 Institut National De La Sante Et De La Recherche Medicale-Inserm Automatic device for the analysis and cloning of cellular cultures as well as for bacteriological analysis
WO2002033047A2 (en) * 1998-04-28 2002-04-25 Nexgenics Bioscience Corp. In vitro embryo culture device
CN1894397A (zh) * 2003-12-18 2007-01-10 株式会社日立医药 细胞培养装置
CN103642688A (zh) * 2007-06-29 2014-03-19 尤尼森斯繁殖技术公司 用于监测和/或培养显微对象的设备、系统和方法
CN103517676A (zh) * 2010-09-27 2014-01-15 奥克索金股份有限公司 用于胚胎、卵母细胞和干细胞的自动化成像和评价的装置、方法和系统
CN106164245A (zh) * 2014-02-03 2016-11-23 尤尼森斯繁殖技术公司 培育器装置及方法
CN106999926A (zh) * 2014-06-02 2017-08-01 安捷伦科技有限公司 用于分析生物样本的单列微板系统和载体
CN105136665A (zh) * 2015-08-17 2015-12-09 宁波键一电子信息技术有限公司 箱内活细胞培养网络型智能成像分析仪

Also Published As

Publication number Publication date
CN107749936A (zh) 2018-03-02

Similar Documents

Publication Publication Date Title
WO2019071648A1 (zh) 一种用于胚胎、卵母细胞或干细胞的成像系统
JP2020129141A (ja) 顕微撮像法
US10047331B2 (en) Tray, a system and a method for monitoring and culturing of a cell culture
CN104580869B (zh) 一种光场相机
TW201740481A (zh) 基板拍攝裝置
US11124764B2 (en) Incubator apparatus and methods
JP2017501429A (ja) 光シート顕微鏡検査用の装置
CN102660457A (zh) 无透镜全息衍射成像血细胞分析计数的装置及方法
CN201141841Y (zh) 基于机器视觉的球体表面缺陷检测系统照明装置
TW201229501A (en) Substrate processing apparatus, substrate processing method, program and computer storage medium
JP2008505628A (ja) 細胞を撮像するための装置
CN1866077A (zh) 傅里叶变换光学系统及体全息存储傅里叶变换光学系统
JP2021514291A (ja) プレノプティック・カメラ・システムを較正するための方法及びシステム
WO2022032920A1 (zh) 投影镜头
US20190197294A1 (en) Imaging device for measuring sperm motility
US10094759B1 (en) Imaging device for measuring sperm motility
RU2014130236A (ru) Панорамная бифокальная линза объектива
CN109188656A (zh) 一种百万像素级中波制冷型定焦镜头
JP2006171432A5 (zh)
CN208883902U (zh) 一种时差成像培养系统
WO2010092341A2 (en) An optical adaptor
CN107726060A (zh) 一种用于曝光机的阵列光源照明装置
TWM483255U (zh) 片劑檢查機之六面檢驗機構
CN106568779A (zh) 液晶显示面板的缺陷检测方法
JP2016140962A5 (zh)

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 17928558

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 17928558

Country of ref document: EP

Kind code of ref document: A1

122 Ep: pct application non-entry in european phase

Ref document number: 17928558

Country of ref document: EP

Kind code of ref document: A1

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 29/10/2020)

122 Ep: pct application non-entry in european phase

Ref document number: 17928558

Country of ref document: EP

Kind code of ref document: A1